UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
 
FORM 10-Q
 
QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934
For the quarterly period ended June 30, 2017
OR
TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934
For the transition period from                       to                     
Commission file number 001-36150
 
SORRENTO THERAPEUTICS, INC.
(Exact Name of Registrant as Specified in Its Charter)
 
 
Delaware
 
33-0344842
(State or Other Jurisdiction of
Incorporation or Organization)
 
(I.R.S. Employer
Identification Number)
4955 Directors Place
San Diego, California 92121
(Address of Principal Executive Offices)
(858) 203-4100
(Registrant’s Telephone Number, Including Area Code)
Indicate by check mark whether the registrant (1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during the preceding 12 months (or for such shorter period that the registrant was required to file such reports), and (2) has been subject to such filing requirements for the past 90 days.    Yes  ☒    No  ☐.
Indicate by check mark whether the registrant has submitted electronically and posted on its corporate Web site, if any, every Interactive Data File required to be submitted and posted pursuant to Rule 405 of Regulation S-T (§232.405 of this chapter) during the preceding 12 months (or for such shorter period that the registrant was required to submit and post such files).    Yes  ☒    No  ☐
Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated file, a smaller reporting company or an emerging growth company. See the definitions of “large accelerated filer,” “accelerated filer,” “smaller reporting company,” and “emerging growth company” in Rule 12b-2 of the Exchange Act:
 
Large accelerated filer
 
  
Accelerated filer
 
 
 
 
 
Non-accelerated filer
 
☐ (Do not check if a smaller reporting company)
  
Smaller reporting company
 
 
 
 
 
 
 
 
Emerging growth company
 
☐  
  
 
 
 
If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act.  
Indicate by check mark whether the registrant is a shell company (as defined in Rule 12b-2 of the Exchange Act).    Yes  ☐    No   ☒.
The number of shares of the issuer’s common stock, par value $0.0001 per share, outstanding as of July 27, 2017 was 76,540,055 .






Sorrento Therapeutics, Inc.
Form 10-Q for the Quarter Ended June 30, 2017
Table of Contents
 
 
 
 
 
 
 
 
 





PART I. FINANCIAL INFORMATION
 
Item 1.    Condensed Consolidated Financial Statements.
 
SORRENTO THERAPEUTICS, INC.
CONDENSED CONSOLIDATED BALANCE SHEETS
(Unaudited) (In thousands, except for share amounts)
 
June 30,
2017
 
December 31,
2016
ASSETS
 

 
 

Current assets:
 

 
 

Cash and cash equivalents
$
53,681

 
$
82,398

Marketable securities
656

 
1,106

Grants and accounts receivables, net
2,376

 
1,696

Income tax receivable
1,468

 
1,289

Prepaid expenses and other, net
2,414

 
3,165

Total current assets
60,595

 
89,654

Property and equipment, net
18,044

 
12,707

Intangibles, net
72,330

 
64,766

Goodwill
38,298

 
41,548

Investments in common stock
112,008

 
112,008

Equity method investments
79,944

 
76,994

Other, net
3,549

 
3,909

Total assets
$
384,768

 
$
401,586

LIABILITIES AND STOCKHOLDERS' EQUITY
 

 
 

Current liabilities:
 

 
 

Accounts payable
$
9,641

 
$
8,282

Accrued payroll and related benefits
3,254

 
3,565

Current portion of deferred compensation

 
1,012

Accrued expenses
6,148

 
4,741

Current portion of deferred revenue
9,666

 
9,666

Current portion of deferred rent
14

 
248

Acquisition consideration payable
50,560

 
48,362

Current portion of debt

 
209

Total current liabilities
79,283

 
76,085

Long-term debt
26,541

 
47,107

Deferred tax liabilities
48,150

 
53,238

Deferred revenue
129,545

 
134,376

Deferred rent and other
5,053

 
4,278

Total liabilities
288,572

 
315,084

Commitments and contingencies


 


Equity:
 

 
 

Sorrento Therapeutics, Inc. equity
 

 
 

Preferred stock, $0.0001 par value; 100,000,000 shares authorized and no shares issued or outstanding

 

Common stock, $0.0001 par value; 750,000,000 shares authorized and 76,540,055 and 50,882,856 shares issued and outstanding at June 30, 2017 and December 31, 2016, respectively
9

 
6

Additional paid-in capital
353,162

 
303,865

Accumulated other comprehensive income (loss)
218

 
(118
)
Accumulated deficit
(211,503
)
 
(174,252
)
Treasury stock, 7,568,182 shares at cost at June 30, 2017, and December 31, 2016, respectively
(49,464
)
 
(49,464
)
Total Sorrento Therapeutics, Inc. stockholders' equity
92,422

 
80,037

Noncontrolling interests
3,774

 
6,465

Total equity
96,196

 
86,502

Total liabilities and stockholders' equity
$
384,768

 
$
401,586

See accompanying unaudited notes

1



SORRENTO THERAPEUTICS, INC.  
CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS
(Unaudited)
(In thousands, except per share amounts)
 
 
Three Months Ended June 30,
 
Six Months Ended June 30,
 
2017
 
2016
 
2017
 
2016
Revenues:
 

 
 

 
 

 
 

Grant
$
94

 
$
328

 
$
195

 
$
757

Royalty and license
2,416

 
12

 
4,833

 
25

Sales and services
2,155

 
562

 
4,511

 
1,108

Total revenues
4,665

 
902

 
9,539

 
1,890

Operating costs and expenses:
 

 
 

 
 

 
 

Costs of revenues
816

 
295

 
1,880

 
654

Research and development
11,179

 
10,744

 
26,062

 
18,408

Acquired in-process research and development

 
32,000

 
200

 
45,000

General and administrative
9,092

 
4,220

 
20,979

 
8,715

Intangible amortization
665

 
111

 
1,292

 
222

Gain on contingent liabilities and acquisition consideration payable
(3,629
)
 
(1,756
)
 
(4,090
)
 
(4,384
)
Total operating costs and expenses
18,123

 
45,614

 
46,323

 
68,615

Loss from operations
(13,458
)
 
(44,712
)
 
(36,784
)
 
(66,725
)
Loss on marketable securities
(609
)
 

 
(450
)
 

Gain on expiration of derivative liability

 

 

 
5,520

Gain (loss) on equity investments
(1,102
)
 
470

 
(2,050
)
 
(29
)
Interest expense
(1,200
)
 
(273
)
 
(2,809
)
 
(580
)
Interest income
232

 
45

 
457

 
58

Income (loss) before income tax
(16,137
)
 
(44,470
)
 
(41,636
)
 
(61,756
)
Income tax expense (benefit)
(1,398
)
 

 
(3,094
)
 

Net income (loss)
(14,739
)
 
(44,470
)
 
(38,542
)
 
(61,756
)
 
 
 
 
 
 
 
 
Net loss attributable to noncontrolling interests
(552
)
 
(1,164
)
 
(1,291
)
 
(2,801
)
Net income (loss) attributable to Sorrento
$
(14,187
)
 
$
(43,306
)
 
$
(37,251
)
 
$
(58,955
)
Net income (loss) per share - basic per share attributable to Sorrento
$
(0.20
)
 
$
(0.93
)
 
$
(0.61
)
 
$
(1.40
)
Net income (loss) per share - diluted per share attributable to Sorrento
$
(0.20
)
 
$
(0.93
)
 
$
(0.61
)
 
$
(1.40
)
Weighted-average shares used during period - basic per share attributable to Sorrento
70,302

 
46,498

 
60,650

 
42,228

Weighted-average shares used during period - diluted per share attributable to Sorrento
70,302

 
46,498

 
60,650

 
42,228

 
See accompanying unaudited notes

2



SORRENTO THERAPEUTICS, INC.
CONDENSED CONSOLIDATED STATEMENTS OF COMPREHENSIVE INCOME (LOSS)
(Unaudited)
(In thousands)
 
 
Three Months Ended June 30,
 
Six Months Ended June 30,
 
2017
 
2016
 
2017
 
2016
Net loss
$
(14,739
)
 
$
(44,470
)
 
$
(38,542
)
 
$
(61,756
)
Other comprehensive income:
 

 
 

 
 

 
 

Foreign currency translation adjustments
274

 

 
336

 

Unrealized loss on marketable securities, net of tax

 
(11,236
)
 

 
(48,125
)
Total other comprehensive loss
(14,465
)
 
(55,706
)
 
(38,206
)
 
(109,881
)
Comprehensive income (loss) attributable to noncontrolling interests
(552
)
 
(1,164
)
 
(1,291
)
 
(2,801
)
Comprehensive income (loss) attributable to Sorrento
$
(13,913
)
 
$
(54,542
)
 
$
(36,915
)
 
$
(107,080
)
 
See accompanying unaudited notes

3



SORRENTO THERAPEUTICS, INC.
CONDENSED CONSOLIDATED STATEMENTS OF STOCKHOLDERS’ EQUITY
(Unaudited)
(In thousands, except for share amounts)
 
 
Common Stock
 
Treasury Stock
 
Additional
Paid-in Capital
 
Accumulated
Other
Comprehensive
Income (Loss)
 
Subscription Receivable
 
Accumulated
Deficit
 
Noncontrolling
Interest
 
 
 
Shares
 
Amount
 
Shares
 
Amount
 
 
 
 
 
Total
Balance, December 31, 2016
50,882,856

 
$
6

 
7,568,182

 
(49,464
)
 
$
303,865

 
$
(118
)
 
$

 
$
(174,252
)
 
$
6,465

 
$
86,502

Scilex acquisition adjustments

 

 

 

 
(627
)
 

 

 

 
(1,400
)
 
(2,027
)
Issuance of common stock for business combinations
797,081

 

 

 

 
1,673

 

 

 

 

 
1,673

Issuance of common stock for public placement and investments, net
24,855,872

 
3

 

 

 
45,595

 

 

 

 

 
45,598

Issuance of common stock for private placement and investments, net
4,246

 

 

 

 
30

 

 

 

 

 
30

Stock-based compensation

 

 

 

 
2,626

 

 

 

 

 
2,626

Foreign currency translation adjustment

 

 

 

 

 
336

 

 

 

 
336

Net loss

 

 

 

 

 

 

 
(37,251
)
 
(1,291
)
 
(38,542
)
Balance, June 30, 2017
76,540,055

 
$
9

 
7,568,182

 
(49,464
)
 
$
353,162

 
$
218

 
$

 
$
(211,503
)
 
$
3,774

 
$
96,196

 
 
 
Common Stock
 
Treasury Stock
 
Additional
Paid-in Capital
 
Accumulated
Other
Comprehensive
Income (Loss)
 
Subscription Receivable
 
Accumulated
Deficit
 
Noncontrolling
Interest
 
 
 
Shares
 
Amount
 
Shares
 
Amount
 
 
 
 
 
Total
Balance, December 31, 2015
37,771,459

 
$
4

 

 

 
$
184,898

 
$
73,579

 
$

 
$
(113,329
)
 
$
(4,214
)
 
$
140,938

Issuance of common stock with exercise of options
89,976

 
1

 

 

 
413

 

 

 

 

 
414

Issuance of common stock for private placement and investments, net
27,587,131

 
2

 

 

 
149,250

 

 

 

 

 
149,252

Stock-based compensation

 

 

 

 
2,391

 

 

 

 

 
2,391

Change in unrealized gain on marketable Securities

 

 

 

 

 
(48,125
)
 

 

 

 
(48,125
)
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Stock subscription

 

 

 

 

 

 
(43,502
)
 

 

 
(43,502
)
Net loss

 

 

 

 

 

 

 
(58,955
)
 
(2,801
)
 
(61,756
)
Balance, June 30, 2016
65,448,566

 
$
7

 

 

 
$
336,952

 
$
25,454

 
$
(43,502
)
 
$
(172,284
)
 
$
(7,015
)
 
$
139,612

 
 
See accompanying unaudited notes

4



SORRENTO THERAPEUTICS, INC.
CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS
(Unaudited) (In thousands )
 
Six Months Ended June 30,
 
2017
 
2016
Operating activities
 
 
 
Net loss
$
(38,542
)
 
$
(61,756
)
Adjustments to reconcile net loss to net cash used in operating activities:
 

 
 

Depreciation and amortization
3,188

 
1,101

Non-cash interest expense
563

 
123

Loss on marketable securities
450

 

Amortization of debt issuance costs
371

 

Stock-based compensation
2,626

 
2,391

Acquired in-process research and development

 
30,000

Provision for doubtful accounts

 
29

Gain on expiration of derivative liability

 
(5,520
)
Loss on equity investments
2,050

 
29

Gain on contingent liabilities and acquisition consideration payable
(4,090
)
 
(4,384
)
Deferred tax provision
(3,064
)
 

Changes in operating assets and liabilities, excluding effect of acquisitions:
 

 
 

Grants and other receivables
(680
)
 
7

Accrued payroll
(311
)
 

Prepaid expenses and other
751

 
478

Deposits and other assets
181

 

Accounts payable
(1,063
)
 
3,084

Deferred revenue
(4,831
)
 
(25
)
Deferred rent and other
(461
)
 

Accrued expenses and other liabilities
1,198

 
2,081

Net cash used for operating activities
(41,664
)
 
(32,362
)
Investing activities
 

 
 

Purchases of property and equipment
(6,783
)
 
(2,230
)
     Investment in Celularity
(3,000
)
 

      Purchase of business, net of cash acquired
(557
)
 

Net cash (used in) provided by investing activities
(10,340
)
 
(2,230
)
Financing activities
 

 
 

Repayment under the amended loan and security agreement
(21,500
)
 
(2,431
)
Payments under deferred compensation arrangements
(1,012
)
 

Proceeds from issuance of common stock, net of issuance costs
45,628

 
95,751

Purchase of treasury stock

 

Proceeds from exercise of stock options

 
413

Net cash provided by (used in) financing activities
23,116

 
93,733

Net change in cash and cash equivalents
(28,888
)
 
59,141

Net effect of exchange rate changes on cash
171

 

Cash and cash equivalents at beginning of period
82,398

 
39,038

Cash and cash equivalents at end of period
$
53,681

 
$
98,179

Supplemental disclosures:
 

 
 

Cash paid during the period for:
 

 
 

Income taxes
$
30

 
$
1

Interest paid
$
2,044

 
$
580

Supplemental disclosures of non-cash investing and financing activities:
 

 
 

Virttu acquisition non-cash consideration
$
15,465

 
$

Change in unrealized gains or (losses) on marketable securities
$

 
$
(62,420
)
Stock subscription and note receivable issued
$

 
$
53,502

Property and equipment costs incurred but not paid
$
422

 
$
578

Investment in Celularity
$
2,000

 
$

 
  See accompanying unaudited notes

5



SORRENTO THERAPEUTICS, INC.
NOTES TO UNAUDITED CONDENSED CONSOLIDATED FINANCIAL STATEMENTS
June 30, 2017
 
1 . Nature of Operations and Business Activities
Na t ure of Operations and Basis of Presentation
Sorrento Therapeutics, Inc. (NASDAQ: SRNE), together with its subsidiaries (collectively, the “Company”) is a clinical stage biotechnology company focused on delivering clinically meaningful therapies to patients and their families, globally. The Company’s primary focus is to transform cancer into a treatable or chronically manageable disease. The Company also has programs assessing the use of its technologies and products in auto-immune, inflammatory, neurodegenerative, infectious diseases and pain indications with high unmet medical needs.
At its core, the Company is an antibody-centric company and leverages its proprietary G-MAB™ library to identify, screen and validate fully human antibodies against high impact oncogenic targets and mutations, immune modulators and intracellular targets. To date, the Company has screened over 100 validated targets and generated a number of fully human antibodies against these targets which are at various stages of preclinical development. These include PD-1, PD-L1, CD38, CD123, CD47, c-MET, VEGFR2, CCR2, OX40, TIGIT and CD137 among others.
The Company’s vision is to leverage these antibodies in conjunction with proprietary targeted delivery modalities to generate the next generation of cancer therapeutics. These modalities include proprietary antibody drug conjugates (“ADCs”), bispecific approaches, as well as T-Cell Receptor (“TCR”)-like antibodies.  With LA Cell, Inc. (“LA Cell”), the Company’s joint venture with City of Hope, the Company’s objective is to become the global leader in the development of antibodies against intracellular targets such as STAT3, mutant KRAS, MYC, p53 and TAU. Additionally, the Company has acquired and is assessing the regulatory and strategic path forward for its portfolio of late stage biosimilar/biobetter antibodies based on Erbitux ® , Remicade ® , Xolair ® , and Simulect ® as these may represent nearer term commercial opportunities.
With each of its programs, the Company aims to tailor its therapies to treat specific stages in the evolution of cancer, from elimination, to equilibrium and escape. In addition, the Company’s objective is to focus on tumors that are resistant to current treatments and where the Company can design focused trials based on a genetic signature or biomarker to ensure patients have the best chance of a durable and significant response. The Company has several immuno-oncology programs that are in or near to entering the clinic.  These include cellular therapies, an oncolytic virus and a palliative care program targeted to treat intractable cancer pain.  Finally, as part of its global aim to provide a wide range of therapeutic products to meet underserved therapeutic markets, the Company has made investments and developed a separate pain focused franchise which the Company believes will serve to provide short term upside to its core thesis.
Through June 30, 2017 , the Company had devoted substantially all of its efforts to product development, raising capital and building infrastructure.  
The accompanying condensed consolidated financial statements include the accounts of the Company’s subsidiaries.  For consolidated entities where the Company owns or is exposed to less than 100% of the economics, the Company records net income (loss) attributable to noncontrolling interests in its condensed consolidated statements of operations equal to the percentage of the economic or ownership interest retained in such entities by the respective noncontrolling parties.  All intercompany balances and transactions have been eliminated in consolidation.
In the opinion of management, the unaudited financial information for the interim periods presented reflects all adjustments, which are only normal, recurring and necessary for a fair statement of financial position, results of operations and cash flows. These condensed consolidated financial statements should be read in conjunction with the consolidated financial statements included in the Company’s Annual Report on Form 10-K for the fiscal year ended December 31, 2016 . Operating results for interim periods are not expected to be indicative of operating results for the Company’s 2017 fiscal year, or any subsequent period.
2. Liquidity and Going Concern
The accompanying condensed consolidated financial statements have been prepared assuming that the Company will continue as a going concern.  The Company has incurred substantial net losses and negative operating cash flows and anticipates that it will continue to do so for the foreseeable future as it continues to identify and invest in advancing product candidates, as well as expanding corporate infrastructure.  

6



As of June 30, 2017 , the Company had a $30.0 million outstanding principal balance on the long-term debt associated with the Loan and Security Agreement, dated November 23, 2016, by and among the Company and certain of its domestic subsidiaries (together with the Company, the “Borrowers”) and Hercules Capital, Inc. (“Hercules”), as amended (as so amended, the “Loan Agreement”).  The Loan Agreement contains covenants requiring the Company (i) to achieve certain fundraising requirements by certain dates and (ii) to maintain $20.0 million of U.S. unrestricted cash prior to achieving the corporate and fundraising milestones. The Company's public offering of common stock in April 2017 for net proceeds of $43.5 million satisfied the fundraising requirements and fundraising milestone.  As of June 30, 2017 , the Company had $53.7 million of cash and cash equivalents, of which $20.0 million is required to be maintained subject to the minimum cash requirement of the Loan Agreement.  The Company’s available cash and financing sources will not be sufficient to meet its current and anticipated cash requirements without additional fundraising.  Accordingly, these factors, among others, raise substantial doubt about the Company’s ability to continue as a going concern.
The Company has plans in place to obtain sufficient additional fundraising to fulfill its operating and capital requirements for the next 12 months and to maintain compliance with the Loan Agreement covenants. The Company’s plans include continuing to fund its operating losses and capital funding needs through public or private equity or debt financings, strategic collaborations, licensing arrangements, asset sales, government grants or other arrangements. Although management believes such plans, if executed as planned, should provide the Company sufficient financing to meet its needs, successful completion of such plans is dependent on factors outside of the Company’s control. As such, management cannot be certain that that such plans will be effectively implemented within one year after the date that the financial statements are issued.  
To the extent the Company is unable to execute on these plans, or is unable to amend the Loan Agreement to maintain compliance with the Loan Agreement covenants, the Company would be in default under the Loan Agreement and the outstanding loan balance may be declared immediately due and payable. Further, the provisions of the Loan Agreement allows for Hercules to exercise a material adverse event clause should the Company incur a material adverse event within the meaning provided by the Loan Agreement, which could include the going concern matters described herein. Should Hercules invoke the material adverse event clause, the outstanding loan balance may be declared immediately due and payable. Although reasonably possible, the Company believes that it is not probable that the material adverse event clause associated with the Loan Agreement will be exercised.
If the Company is unable to raise additional capital in sufficient amounts or on terms acceptable, the Company may have to significantly delay, scale back or discontinue the research, development or commercialization of one or more of its product candidates. The Company may also seek collaborators for one or more of its current or future product candidates at an earlier stage than otherwise would be desirable or on terms that are less favorable than might otherwise be available.
The condensed consolidated financial statements do not reflect any adjustments that might be necessary if the Company is unable to continue as a going concern.
Universal Shelf Registration
In November 2014, the Company filed a universal shelf registration statement on Form S-3 (the “Shelf Registration Statement”) with the SEC, which was declared effective by the SEC in December 2014. This Shelf Registration Statement provides the Company with the ability to offer up to $250 million of securities, including equity and other securities as described in the registration statement. Included in the 2014 shelf registration is a sales agreement prospectus covering the offering, issuance and sale by the Company of up to a maximum aggregate offering price of $50.0 million of the Company’s common stock that may be issued and sold under a sales agreement with MLV & Co. LLC (the “ATM Facility”). During the twelve months ended December 31, 2016 and the six months ended June 30, 2017 , the Company sold approximately $3.6 million and $2.5 million shares of common stock under the ATM Facility, respectively.  The Company can offer up to $43.9 million of additional shares of common stock under the ATM Facility, subject to certain limitations.  On April 19, 2017, the Company completed a public offering of $47.5 million shares of common stock pursuant to the Shelf Registration Statement for net proceeds of approximately $43.5 million .
Pursuant to the Shelf Registration Statement, the Company may offer additional securities from time to time and through one or more methods of distribution, subject to market conditions and the Company’s capital needs. Specific terms and prices will be determined at the time of each offering under a separate prospectus supplement, which will be filed with the SEC at the time of any offering. However, the Company cannot be sure that such additional funds will be available on reasonable terms, or at all.
2016 Private Investment in Public Entity Financing
On April 3, 2016, the Company entered into a Securities Purchase Agreement (the “ABG Purchase Agreement”) with ABG SRNE Limited and Ally Bridge LB Healthcare Master Fund Limited (collectively, “Ally Bridge”), pursuant to which,

7



among other things, the Company agreed to issue and sell to Ally Bridge and other purchasers designated by Ally Bridge (collectively, the “ABG Purchasers”), in a private placement transaction (the “ABG Private Placement”), up to $50.0 million in shares of the Company’s common stock and warrants to purchase shares of common stock. Upon the closing of the ABG Private Placement, the Company issued to the ABG Purchasers (1) an aggregate of 9,009,005 shares (the “ABG Shares”) of common stock,   and (2) warrants to purchase an aggregate of 2,702,700 shares of common stock (each, an “ABG Warrant”).   Each ABG Warrant had an exercise price of $8.50 per share, was immediately exercisable upon issuance, had a term of three years and was exercisable on a cash or cashless exercise basis. 
Under the terms of the ABG Purchase Agreement, the Company was obligated to prepare and file with the SEC, within 30 days of the closing date of the ABG Private Placement, a registration statement to register for resale the ABG Shares and the shares of common stock issuable upon exercise of each ABG Warrant (the “ABG Warrant Shares”), and may be required to effect certain registrations to register for resale the ABG Shares and the ABG Warrant Shares in connection with certain “piggy-back” registration rights granted to the ABG Purchasers.
On April 3, 2016, the Company also entered into a Securities Purchase Agreement (collectively, the “Additional Purchase Agreements”) with each of Beijing Shijilongxin Investment Co., Ltd. ( “Beijing Shijilongxin”), FREJOY Investment Management Co., Ltd. (“Frejoy”) and Yuhan Corporation (“Yuhan”), pursuant to which, among other things, the Company agreed to issue and sell, in separate private placement transactions: (1)to Beijing Shijilongxin, 8,108,108 shares of common stock, and a warrant to purchase 1,176,471 shares of common stock, for an aggregate purchase price of $45.0 million ; (2)to Frejoy, 8,108,108 shares of common stock, and a warrant to purchase 1,176,471 shares of common stock, for an aggregate purchase price of $45.0 million ; and (3)to Yuhan, 1,801,802 shares of common stock, and a warrant to purchase 235,294 shares of common stock, for an aggregate purchase price of $10.0 million . The warrants issued pursuant to each of the Additional Purchase Agreements (collectively, the “Additional Warrants” and, together with each ABG Warrant, the “Warrants”) had an exercise price of $8.50 per share, were immediately exercisable upon issuance, had a term of three years and were exercisable on a cash or cashless exercise basis.
Under the terms of the Additional Purchase Agreements, each of Beijing Shijilongxin, Frejoy and Yuhan had the right to demand, at any time beginning six months after the closing of the transactions contemplated by the applicable Additional Purchase Agreement, that the Company prepare and file with the SEC a registration statement to register for resale such investor’s shares of common stock purchased pursuant to the applicable Additional Purchase Agreement and the shares of common stock issuable upon exercise of such investor’s Additional Warrant. In addition, the Company may be required to effect certain registrations to register for resale such shares in connection with certain “piggy-back” registration rights granted to Beijing Shijilongxin, Frejoy and Yuhan.
On May 2, 2016, the Company closed its private placement of common stock and warrants with Yuhan for gross proceeds of $10.0 million .  Yuhan purchased 1,801,802 shares of common stock at $5.55 per share and a warrant to purchase 235,294 shares of common stock.  The warrant was exercisable for three years at an exercise price of $8.50 per share.
Between May 31, 2016 and June 7, 2016, the Company closed on the remainder of the $150.0 million financing with the ABG Purchasers, Beijing Shijilongxin, and Frejoy. The ABG Purchasers led the financing and, together with Beijing Shijilongxin and Frejoy, collectively purchased  25,225,221 shares of common stock at  $5.55  per share, and warrants to purchase 5,055,642 shares of common stock for total cash consideration of  $86.5 million and secured promissory notes (the “Notes”) in an aggregate principal amount of $53.5 million .
On December 31, 2016, the Company entered into Warrant and Note Cancellation and Share Forfeiture Agreements (the “Cancellation and Forfeiture Agreements”) with certain investors (the “Investors”) that held an aggregate of 7,838,259 shares of common stock and certain of the Warrants granting the right to purchase an aggregate of 1,137,316 shares of common stock.  Pursuant to the Cancellation and Forfeiture Agreements, effective December 31, 2016, the Warrants held by the Investors and the Notes, of which $43.5 million was then outstanding, were cancelled and the shares of common stock held by the Investors were forfeited and returned to the Company.
If the Company raises additional funds by issuing equity securities, substantial dilution to existing stockholders would result. If the Company raises additional funds by incurring debt financing, the terms of the debt may involve significant cash payment obligations as well as covenants and specific financial ratios that may restrict the Company’s ability to operate its business.
3. Significant Accounting Policies
Use of Estimates

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The preparation of consolidated financial statements in conformity with accounting principles generally accepted in the United States of America (“GAAP”) requires management to make estimates and assumptions that affect the reported amounts of assets and liabilities and disclosure of contingent assets and liabilities at the date of the financial statements and the reported amounts of expenses during the reporting period.  Management believes that these estimates are reasonable; however, actual results may differ from these estimates.
Cash and Cash Equivalents
The Company considers all highly liquid investments purchased with original maturities of three months or less to be cash equivalents. The Company minimizes its credit risk associated with cash and cash equivalents by periodically evaluating the credit quality of its primary financial institution. The balance at times may exceed federally insured limits. The Company has not experienced any losses on such accounts.
Fair Value of Financial Instruments
The Company follows accounting guidance on fair value measurements for financial instruments measured on a recurring basis, as well as for certain assets and liabilities that are initially recorded at their estimated fair values. Fair value is defined as the exit price, or the amount that would be received from selling an asset or paid to transfer a liability in an orderly transaction between market participants at the measurement date. The Company uses the following three-level hierarchy that maximizes the use of observable inputs and minimizes the use of unobservable inputs to value its financial instruments:
Level 1: Observable inputs such as unadjusted quoted prices in active markets for identical instruments.
Level 2: Quoted prices for similar instruments that are directly or indirectly observable in the marketplace.
Level 3: Significant unobservable inputs which are supported by little or no market activity and that are financial instruments whose values are determined using pricing models, discounted cash flow methodologies, or similar techniques, as well as instruments for which the determination of fair value requires significant judgment or estimation.
Financial instruments measured at fair value are classified in their entirety based on the lowest level of input that is significant to the fair value measurement. The Company’s assessment of the significance of a particular input to the fair value measurement in its entirety requires it to make judgments and consider factors specific to the asset or liability. The use of different assumptions and/or estimation methodologies may have a material effect on estimated fair values. Accordingly, the fair value estimates disclosed or initial amounts recorded may not be indicative of the amount that the Company or holders of the instruments could realize in a current market exchange.
The carrying amounts of cash equivalents and marketable securities approximate their fair value based upon quoted market prices. Certain of the Company’s financial instruments are not measured at fair value on a recurring basis, but are recorded at amounts that approximate their fair value due to their liquid or short-term nature, such as cash, accounts receivable and payable, and other financial instruments in current assets or current liabilities.
Marketable Securities
Marketable securities are designated either as trading or available-for-sale securities and are accounted for at fair value. Marketable securities are classified as short-term or long-term based on the nature of the securities and their availability to meet current operating requirements. Marketable securities that are readily available for use in current operations and are classified as short-term available-for-sale securities are reported as a component of current assets in the accompanying condensed consolidated balance sheets. Marketable securities that are not trading securities and are not considered available for use in current operations are classified as long-term available-for-sale securities and are reported as a component of long-term assets in the accompanying condensed consolidated balance sheets.
Securities that are classified as trading are carried at fair value, with changes to fair value reported as a component of income. Securities that are classified as available-for-sale are carried at fair value, with temporary unrealized gains and losses reported as a component of stockholders' equity until their disposition. The cost of securities sold is based on the specific identification method.
All of the Company’s marketable securities are subject to a periodic impairment review. The Company recognizes an impairment charge when a decline in the fair value of its investments below the cost basis is judged to be other-than-temporary.  For the three months ended June 30, 2017 and 2016 , no other-than-temporary impairment charges were recorded.  
Grants and Accounts Receivable

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Grants receivable at June 30, 2017 and December 31, 2016 represent amounts due under several federal contracts with the National Institute of Allergy and Infectious Diseases (“NIAID”), a division of the National Institutes of Health (“NIH”). The Company considers the grants receivable to be fully collectible; accordingly, no allowance for doubtful amounts has been established. If amounts become uncollectible, they are charged to operations.
Accounts receivable at June 30, 2017 and December 31, 2016 consist of trade receivables from sales and services provided to certain customers, which are generally unsecured and due within 30 days. Estimated credit losses related to trade accounts receivable are recorded as general and administrative expenses and as an allowance for doubtful accounts within grants and accounts receivable, net. The Company reviews reserves and makes adjustments based on historical experience and known collectability issues and disputes. When internal collection efforts on accounts have been exhausted, the accounts are written off by reducing the allowance for doubtful accounts. As of each of June 30, 2017 and December 31, 2016 , the allowance for doubtful accounts was $20 thousand and $26 thousand , respectively.  
Property and Equipment
Property and equipment are carried at cost less accumulated depreciation. Depreciation of property and equipment is computed using the straight-line method over the estimated useful lives of the assets, which are generally three to five years . Leasehold improvements are amortized over the lesser of the life of the lease or the life of the asset. Repairs and maintenance are charged to expense as incurred.
Acquisitions and Intangibles
The Company has engaged in business combination activity. The accounting for business combinations requires management to make judgments and estimates of the fair value of assets acquired, including the identification and valuation of intangible assets, as well as liabilities assumed. Such judgments and estimates directly impact the amount of goodwill recognized in connection with each acquisition, as goodwill presents the excess of the purchase price of an acquired business over the fair value of its net tangible and identifiable intangible assets.
During the first quarter of 2017 , the Company identified an error in the valuation of acquisition consideration associated with the Scilex Pharmaceuticals Inc. (“Scilex”) acquisition, primarily related to the acquisition consideration payable, resulting in an overstatement of acquisition consideration payable of $6.5 million , and a corresponding overstatement of intangible assets of $6.7 million , goodwill of $ 4.6 million , deferred income tax liability of $2.8 million , additional paid-in capital of $0.6 million , and noncontrolling interest of $1.4 million as of December 31, 2016 . The Company evaluated the materiality of this misstatement from quantitative and qualitative perspectives, and concluded that it was immaterial to the prior periods. Consequently, the Company corrected this error by recording the adjustment in the Company’s condensed consolidated balance sheet in the quarter ended March 31, 2017.
Goodwill and Other Long-Lived Assets
Goodwill, which has an indefinite useful life, represents the excess of cost over fair value of net assets acquired. Goodwill is reviewed for impairment at least annually during the fourth quarter, or more frequently if events occur indicating the potential for impairment. During its goodwill impairment review, the Company may assess qualitative factors to determine whether it is more likely than not that the fair value of its reporting unit is less than its carrying amount, including goodwill. The qualitative factors include, but are not limited to, macroeconomic conditions, industry and market considerations, and the overall financial performance of the Company. If, after assessing the totality of these qualitative factors, the Company determines that it is not more likely than not that the fair value of its reporting unit is less than its carrying amount, then no additional assessment is deemed necessary. Otherwise, the Company proceeds to perform the two-step test for goodwill impairment. The first step involves comparing the estimated fair value of the reporting unit with its carrying value, including goodwill. If the carrying amount of the reporting unit exceeds its fair value, the Company performs the second step of the goodwill impairment test to determine the amount of loss, which involves comparing the implied fair value of the goodwill to the carrying value of the goodwill. The Company may also elect to bypass the qualitative assessment in a period and elect to proceed to perform the first step of the goodwill impairment test. The Company performed its annual assessment for goodwill impairment in the fourth quarter of 2016 , noting no impairment. There have not been any triggering events indicating the potential for impairment through June 30, 2017 .
The Company evaluates its long-lived and intangible assets with definite lives, such as property and equipment, acquired technology, customer relationships, patent and license rights, for impairment by considering competition by products prescribed for the same indication, the likelihood and estimated future entry of non-generic and generic competition with the same or similar indication and other related factors. The factors that drive the estimate of useful life are often uncertain and are reviewed on a periodic basis or when events occur that warrant review. Recoverability is measured by comparison of the assets’

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book value to future net undiscounted cash flows that the assets are expected to generate. There have not been any impairment losses of long-lived assets through June 30, 2017 .
Acquisition Consideration Payable - Gain on Contingent Liabilities
Acquisition consideration payable relates to the Company’s acquisition of businesses and various other assets and is recorded on the Company’s condensed consolidated balance sheets at fair value and is re-measured at each balance sheet date until such contingent liabilities have been settled, with changes in fair value recorded as gain on contingent liabilities. The Company estimates the fair value of contingent consideration based on level 3 inputs primarily driven by the probability of achieving certain financing or operating related milestones.  
The condensed consolidated statements of operations and comprehensive income (loss) for the three and six months ended June 30, 2016 and stockholders’ equity and of cash flows for the six months ended June 30, 2016 have been restated to correct for the effects of an immaterial error in the interim periods related to the re-measurement of acquisition consideration payable. As a result of the restatement, an adjustment of $1.7 million and $4.4 million to gain on contingent liabilities has been reflected in operating costs and expenses in the condensed consolidated statements of operations for the three and six months ended June 30, 2016, respectively.  This adjustment includes a gain of $991 thousand that relates to 2015 but was recognized in the three months ended March 31, 2016. As a result of this adjustment, the financial results for the three months ended June 30, 2016 reflect the impact of the adjustment which resulted in a decrease in operating costs and expenses from $47.3 million to $45.6 million , a decrease in net loss attributable to the Company from $44.9 million to $43.3 million , and a decrease in net loss per share from ($0.97) to ($0.93) for the quarter ended June 30, 2016. The financial results for the six months ended June 30, 2016 reflect the impact of the adjustment, which resulted in a decrease in operating costs and expenses from $73.0 million to $68.6 million , a decrease in net loss attributable to the Company from $63.3 million to $59.0 million , and a decrease in net loss per share from (1.50) to ($1.40) for the six months ended June 30, 2016.
Derivative Liability
Derivative liabilities are recorded on the Company’s condensed consolidated balance sheets at their fair value on the date of issuance and are revalued on each balance sheet date until such instruments are exercised or expire, with changes in the fair value between reporting periods recorded as other income or expense.  The Company estimates the fair value of derivative liabilities using the Black-Scholes option pricing model.
Investments in Other Entities
The Company holds a portfolio of investments in equity securities that are accounted for under either the equity method or cost method. Investments in entities over which the Company has significant influence but not a controlling interest are accounted for using the equity method, with the Company’s share of earnings or losses reported in loss on equity investments.
The Company’s cost method investments are included in investments in common stock on the condensed consolidated balance sheets.  The Company’s equity method investments are included in equity method investments on the condensed consolidated balance sheets.
All investments are reviewed on a regular basis for possible impairment. If an investment's fair value is determined to be less than its net carrying value and the decline is determined to be other-than-temporary, the investment is written down to its fair value. Such an evaluation is judgmental and dependent on specific facts and circumstances. Factors considered in determining whether an other-than-temporary decline in value has occurred include: the magnitude of the impairment and length of time that the market value was below the cost basis; financial condition and business prospects of the investee; the Company’s intent and ability to retain the investment for a sufficient period of time to allow for recovery in market value of the investment; issues that raise concerns about the investee's ability to continue as a going concern; any other information that the Company may be aware of related to the investment. The Company does not report the fair value of its equity investments in non-publicly traded companies because it is not practical to do so.
Research and Development Costs and Collaborations
All research and development costs are charged to expense as incurred. Such costs primarily consist of lab supplies, contract services, stock-based compensation expense, salaries and related benefits.

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Acquired In-Process Research and Development Expense
The Company has acquired and may continue to acquire the rights to develop and commercialize new drug candidates. The up-front payments to acquire a new drug compound, as well as future milestone payments, are immediately expensed as acquired in-process research and development provided that the drug has not achieved regulatory approval for marketing and, absent obtaining such approval, have no alternative future use. Prior to November 8, 2016, all acquired in-process research and development was expensed immediately. The acquired in-process research and development related to the business combination of Virttu Biologics Limited ("Virttu") and Scilex for which certain products are under development and expected to be commercialized in the future was capitalized and recorded within “Intangibles, net” on the accompanying condensed consolidated balance sheet. Capitalized in-process research and development will be reviewed annually for impairment or more frequently as changes in circumstance or the occurrence of events suggest that the remaining value may not be recoverable.
Income Taxes
The provisions of the Financial Accounting Standards Board (“FASB”) Accounting Standards Codification (“ASC”) Topic 740 “Income Taxes,” addresses the determination of whether tax benefits claimed or expected to be claimed on a tax return should be recorded in the financial statements. Under ASC Topic 740-10, the Company may recognize the tax benefit from an uncertain tax position only if it is more likely than not that the tax position will be sustained on examination by taxing authorities, based on the technical merits of the position. The Company has determined that it has uncertain tax positions.
The Company accounts for income taxes using the asset and liability method to compute the differences between the tax basis of assets and liabilities and the related financial amounts, using currently enacted tax rates.
The Company has deferred tax assets, which are subject to periodic recoverability assessments. Valuation allowances are established, when necessary, to reduce deferred tax assets to the amount that more likely than not will be realized. As of each of December 31, 2016 and June 30, 2017 , the Company maintained a full valuation allowance against its deferred tax assets, with the exception of an amount equal to its deferred tax liabilities, which can be expected to reverse over a definite life, an amount equal to its alternative minimum tax credits and state research and development tax credits for which there is no expiration and the deferred tax assets related to its Scilex investment.
Revenue Recognition
The Company’s revenues are generated primarily from license fees, various NIH grant awards, and from the sale of customized reagents and the provision of contract development services. The revenue from the NIH grant awards is based upon subcontractor and internal costs incurred that are specifically covered by the grant, and where applicable, a facilities and administrative rate that provides funding for overhead expenses. These revenues are recognized when expenses have been incurred by subcontractors or when the Company incurs internal expenses that are related to the grant.
License fees for the licensing of product rights are recorded as deferred revenue upon receipt of cash and recognized as revenue on a straight-line basis over the license period.
Revenues from sales are generated from the sale of customized reagents which include industrial standard cytotoxins, linkers, and linker-toxins used for preparing ADCs.  Contract development services include providing synthetic expertise to customers’ synthesis by delivering proprietary cytotoxins, linkers and linker-toxins and ADC service using industry standard toxin and antibodies provided by customers. Revenue is recognized when, (i) persuasive evidence of an arrangement exists, (ii) the product has been shipped or the services have been rendered, (iii) the price is fixed or determinable, and (iv) collectability is reasonably assured.  Royalty revenues will be recognized as earned per the terms of underlying royalty bearing contracts.
The Company is obligated to accept from customers the return of products sold that are damaged or do not meet certain specifications. The Company may authorize the return of products sold in accordance with the terms of its sales contracts, and estimates allowances for such amounts at the time of sale. The Company has not experienced any sales returns.
Stock-based Compensation
The Company accounts for stock-based compensation in accordance with FASB ASC Topic 718 “ Compensation – Stock Compensation, ” which establishes accounting for equity instruments exchanged for employee services. Under such provisions, stock-based compensation cost is generally measured at the grant date, based on the calculated fair value of the award and an estimate of forfeitures, and is recognized as an expense, under the straight-line method, over the employee’s requisite service period (generally the vesting period of the equity grant).

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The Company accounts for equity instruments, including restricted stock or stock options, issued to non-employees in accordance with authoritative guidance for equity based payments to non-employees. Stock options issued to non-employees are accounted for at their estimated fair value determined using the Black-Scholes option-pricing model. The fair value of options and restricted stock granted to non-employees is re-measured over the vesting period, and the resulting changes in fair value are recognized as expense in the period of the change in proportion to the services rendered to date.
Comprehensive (Loss) Income
Comprehensive loss is primarily comprised of net loss and adjustments for the change in unrealized gains and losses on the Company’s investments in available-for-sale marketable securities, net of taxes. The Company displays comprehensive loss and its components in its condensed consolidated statements of comprehensive (loss) income.
Net Loss per Share
Basic net loss per share is computed by dividing net loss for the period by the weighted average number of common shares outstanding during the period. Diluted net loss per share reflects the additional dilution from potential issuances of common stock, such as stock issuable pursuant to the exercise of stock options or the exercise of outstanding warrants. The treasury stock method and if-converted method are used to calculate the potential dilutive effect of these common stock equivalents. Potentially dilutive shares are excluded from the computation of diluted net loss per share when their effect is anti-dilutive. In periods where a net loss is presented, all potentially dilutive securities are anti-dilutive and are excluded from the computation of diluted net loss per share.
Segment Information
The Company is engaged primarily in the discovery and development of innovative therapies focused on oncology and the treatment of chronic cancer pain as well as immunology and infectious diseases based on its platform technologies. Accordingly, the Company has determined that it operates in one operating segment.
Recent Accounting Pronouncements
In May 2014, the FASB issued Accounting Standards Update (“ASU”) No. 2014-09, Revenue from Contracts with Customers (Topic 606) , which supersedes all existing revenue recognition requirements, including most industry-specific guidance. The new standard requires a company to recognize revenue when it transfers goods or services to customers in an amount that reflects the consideration that the company expects to receive for those goods or services. ASU No. 2014-09 was originally effective for annual reporting periods beginning after December 15, 2016, and interim periods thereafter.  In August 2015, the FASB issued ASU No. 2015-14, Revenue from Contracts with Customers (Topic 606): Deferral of the Effective Date, which delayed the effective date of the new standard for annual reporting periods beginning after December 15, 2017, and interim periods thereafter.  The FASB also agreed to allow entities to choose to adopt the standard as of the original effective date.  The standard allows for either a full retrospective or modified retrospective method of adoption. The Company expects to adopt this standard using the modified retrospective approach and does not expect the adoption to have a material impact on its financial position and results of operations. The Company currently anticipates adopting this standard on its effective date, January 1, 2018.
In January 2016, the FASB issued ASU No. 2016-01, Financial Instruments--Overall (Subtopic 825-10): Recognition and Measurement of Financial Assets and Financial Liabilities. The ASU amends the guidance in U.S. GAAP on the classification and measurement of financial instruments. Changes to the current guidance primarily affect the accounting for equity investments, financial liabilities under the fair value option, and the presentation and disclosure requirements for financial instruments. ASU No. 2016-01 is effective for fiscal years and interim periods beginning after December 15, 2017, and upon adoption, an entity should apply the amendments by means of a cumulative-effect adjustment to the balance sheet at the beginning of the first reporting period in which the guidance is effective. Early adoption is not permitted except for the provision to record fair value changes for financial liabilities under the fair value option resulting from instrument-specific credit risk in other comprehensive income.  The adoption of this standard is not expected to have a material impact on the Company’s consolidated financial position, results of operations or cash flows.
In February 2016, the FASB issued ASU No. 2016-02, Leases . ASU No. 2016-02 is aimed at making leasing activities more transparent and comparable, and requires substantially all leases be recognized by lessees on their balance sheet as a right-of-use asset and corresponding lease liability, including leases currently accounted for as operating leases. ASU No. 2016-02 is effective for  financial statements issued for fiscal years beginning after December 15, 2018, and interim periods within those fiscal years. Early adoption is permitted. The Company is currently evaluating the impact that the adoption of ASU No. 2016-02 will have on its consolidated financial position, results of operations and cash flows.

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In March 2016, the FASB issued ASU No. 2016-06, Derivatives and Hedging (Topic 815): Contingent Put and Call Options in Debt Instruments, which clarifies the steps required when assessing whether the economic characteristics and risks of call (put) options that can accelerate the payment of principal on debt instruments are clearly and closely related to their debt hosts based on a four-step decision process. ASU No. 2016-06 is effective for financial statements issued for fiscal years beginning after December 15, 2016, and interim periods within those fiscal years. The adoption of this standard did not have a material impact on the Company’s consolidated financial position, results of operations or cash flows.
In March 2016, the FASB issued ASU No. 2016-07, Investments – Equity Method and Joint Ventures (Topic 323): Simplifying the Transition to the Equity Method of Accounting, requires that an entity that has an available-for-sale equity security that becomes qualified for the equity method of accounting recognize through earnings the unrealized holding gain or loss in accumulated other comprehensive income at the date the investment becomes qualified for the equity method and eliminates the requirement for retroactive adjustment of the investment as a result of an increase in the level of ownership interest or degree of influence. ASU No. 2016-07 is effective for financial statements issued for fiscal years and interim periods within those fiscal years beginning after December 15, 2016. The adoption of this standard did not have a material impact on the Company’s consolidated financial position, results of operations or cash flows.
In March 2016, the FASB issued ASU No. 2016-09, Compensation – Stock Compensation (Topic 718): Improvements to Employee Share-Based Payment Accounting. The ASU includes various provisions to simplify the accounting for share-based payments with the goal of reducing the cost and complexity of accounting for share-based payments. The amendments may significantly impact net income, earnings per share and the statement of cash flows as well as present implementation and administration challenges for companies with significant share-based payment activities. ASU No. 2016-09 is effective for public companies for fiscal years beginning after December 15, 2016, including interim periods within those fiscal years. The adoption of this standard did not have a material impact on the Company’s consolidated financial position, results of operations or cash flows.
In June 2016, the FASB issued ASU No. 2016-13, Financial Instruments - Credit Losses (Topic 326): Measurement of Credit Losses on Financial Instruments to improve financial reporting by requiring timelier recording of credit losses on loans and other financial instruments held by financial institutions and other organizations. The ASU requires the measurement of all expected credit losses for financial assets held at the reporting date based on historical experience, current conditions and reasonable and supportable forecasts. The ASU also requires enhanced disclosures to help investors and other financial statement users better understand significant estimates and judgments used in estimating credit losses, as well as the credit quality and underwriting standards of an organization’s portfolio. The ASU is effective for fiscal years beginning after December 15, 2019, including interim periods within those fiscal years. Early application will be permitted for all organizations for fiscal years beginning after December 15, 2018, including interim periods within those fiscal years. The Company is currently evaluating the impact that the adoption of ASU No. 2016-13 will have on its consolidated financial position, results of operations and cash flows.
In August 2016, the FASB issued ASU No. 2016-15, Statement of Cash Flows (Topic 230): Classification of Certain Cash Receipts and Cash Payments, to improve financial reporting in regards to how certain transactions are classified in the statement of cash flows. The ASU requires that (1) debt extinguishment costs be classified as cash outflows for financing activities and provides additional classification guidance for the statement of cash flows, (2) the classification of cash receipts and payments that have aspects of more than one class of cash flows to be determined by applying specific guidance under generally accepted accounting principles, and (3) each separately identifiable source or use within the cash receipts and payments be classified on the basis of their nature in financing, investing or operating activities. The ASU is effective for fiscal years beginning after December 15, 2017, including interim periods within those fiscal years.  The Company does not believe the adoption of ASU No. 2016-15 will have a material impact on the Company’s consolidated financial position, results of operations or cash flows.
In January 2017, the FASB issued ASU No. 2017-01, Business Combinations (Topic 805): Clarifying the Definition of a Business, to clarify the definition of a business to add guidance for evaluating whether transactions should be accounted for as acquisitions (or disposals) of assets or businesses. Specifically, this ASU provides a screen to assist entities in determining when a set should not be considered a business, which screen provides that if substantially all of the fair value of the gross assets acquired (or disposed of) is concentrated in a single identifiable asset or group of similar assets, the set is not a business. The ASU is effective for fiscal years beginning after December 15, 2017, including interim periods within those fiscal years.  The Company does not believe the adoption of ASU No. 2017-01 will have a material impact on the Company’s consolidated financial position, results of operations or cash flows.
In January 2017, the FASB issued ASU No. 2017-04, Simplifying the Test for Goodwill Impairment (Topic 350) . This standard eliminates Step 2 from the goodwill impairment test, instead requiring an entity to recognize a goodwill impairment charge for the amount by which the goodwill carrying amount exceeds the reporting unit’s fair value. This guidance is effective

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for interim and annual goodwill impairment tests in fiscal years beginning after December 15, 2019 with early adoption permitted. This guidance must be applied on a prospective basis. The Company is currently evaluating the impact that the adoption of ASU No. 2017-04 will have on the Company’s consolidated financial position, results of operations or cash flows.
In May 2017, the FASB issued ASU No. 2017-09, Compensation - Stock Compensation (Topic 718): Scope of Modification Accounting, to provide clarity and reduce both the diversity in practice and cost of complexity when applying the guidance. Specifically, the ASU provides additional modification conditions in determining whether or not modification accounting should be applied. The ASU is effective for fiscal years beginning after December 15, 2017, including interim periods within those fiscal years.  The Company does not believe the adoption of ASU No. 2017-09 will have a material impact on the Company’s consolidated financial position, results of operations or cash flows.
4. Acquisitions
Acquisition of Virttu Biologics Limited
On April 27, 2017, the Company entered into a Share Purchase Agreement (the “Virttu Purchase Agreement”) with TNK Therapeutics, Inc., a majority-owned subsidiary of the Company (“TNK”), Virttu, the shareholders of Virttu (the “Virttu Shareholders”) and Dayspring Ventures Limited, as the representative of the Virttu Shareholders, pursuant to which, among other things, TNK acquired from the Virttu Shareholders 100% of the outstanding ordinary shares of Virttu (the “Virttu Acquisition”).
Virttu focuses on the development of oncolytic viruses that infect and selectively multiply in and destroy tumor cells without damaging healthy tissue. Its lead oncolytic virus candidate, Seprehvir, infects and replicates in cancer cells selectively, leaving normal cells unharmed.
Under the Virttu Purchase Agreement, the total amount of the consideration payable to the Virttu Shareholders in the Virttu Acquisition is equal to $25 million , less Virttu’s net debt (the “Virttu Base Consideration”). An additional $10 million contingent consideration is payable upon the achievement of certain regulatory milestones (as described below) (the “Regulatory Approval Consideration”).
At the closing of the Virttu Acquisition (the “Closing”), the Company issued to the Virttu Shareholders consideration valued at approximately $2.2 million , which consisted primarily of an aggregate of 797,081 shares (the “Virttu Closing Shares”) and approximately $557,000 in cash (the “Cash Consideration”). The issuance of the Virttu Closing Shares and the payment of the Cash Consideration satisfied TNK’s obligation to pay 20% of the Virttu Base Consideration at the Closing. Under the terms of the Virttu Purchase Agreement, the Company agreed to provide additional consideration to the Virttu Shareholders, as follows:
(1) Upon a financing resulting in gross proceeds (individually or in the aggregate) to TNK of at least $50.0 million (a “Qualified Financing”), TNK will issue to the Virttu Shareholders an aggregate number of shares of its capital stock (“TNK Capital Stock”) as is equal to the quotient obtained by dividing 80% of the Virttu Base Consideration by the lowest per share price paid by investors in the Qualified Financing (the “TNK Financing Consideration”); provided, however, that 20% of the TNK Financing Consideration shall be held in escrow until April 27, 2018 (the “Financing Due Date”), to be used to, among other things, satisfy the indemnification obligations of the Virttu Shareholders. In the event that a Qualified Financing does not occur, then on the Financing Due Date, the Company will issue to the Virttu Shareholders an aggregate number of shares of the Company’s common stock as is equal to the quotient obtained by dividing 80% of the Virttu Base Consideration, by $5.55 (as adjusted, as appropriate, to reflect any stock splits or similar events affecting the Company’s common stock after the Closing).
(2) Within 45 business days after Virttu becomes aware that certain governmental bodies in the United States, the European Union, the United Kingdom or Japan have approved for commercialization, on or before October 26, 2024, Seprehvir (or any enhancement, combination or derivative thereof) as a monotherapy or in combination with one or more other active components (each of the first two such approvals by a governmental body being a “Regulatory Approval”), TNK shall pay half of the Regulatory Approval Consideration to the Virttu Shareholders, in a combination of (a) up to $5.0 million in cash (the “Regulatory Approval Cash”) and/or (b) (i) such number of shares of the Company’s common stock as is equal to the quotient obtained by dividing $5.0 million less the Regulatory Approval Cash (the “Regulatory Approval Share Value”) by the 30 Day VWAP (as defined below) of one share of the Company’s common stock; (ii) if TNK has completed its first public offering of TNK Capital Stock, the number of shares of TNK Capital Stock as is equal to the quotient obtained by dividing the Regulatory Approval Share Value by the 30 Day VWAP of one share of TNK Capital Stock; or (iii) such number of shares of common stock of a publicly traded company as is equal to the quotient obtained by dividing the Regulatory Approval Share Value by the volume weighted average price of the relevant security, as reported on the Nasdaq Capital Market (or other principal stock exchange or securities market on which the shares are then listed or quoted) for the thirty trading days immediately following

15



the receipt of Regulatory Approval (the “30 Day VWAP”), with the composition of the Regulatory Approval Consideration to be at TNK’s option. In order for a second regulatory approval to qualify as a Regulatory Approval under the Purchase Agreement, the second approval must be granted by a different governmental body in a different jurisdiction than that which granted the first Regulatory Approval.
At April 27, 2017, the 80% of the Virttu Base Consideration was valued at $12.8 million . The fair value of the 80% of the Virttu Base Consideration is recorded as a current liability and will be adjusted quarterly for changes in fair value or as events and circumstances arise. At April 27, 2017, the contingent Regulatory Approval Consideration was valued at $1.0 million . The fair value of the contingent Regulatory Approval Consideration is recorded as a non-current liability within "Deferred rent and other" on the accompanying condensed consolidated balance sheet and will be adjusted quarterly for changes in fair value or as events and circumstances arise.
The consolidated financial statements include the preliminary results of operations from this transaction, which have been accounted for as a business combination, and require, among other things, that assets acquired and liabilities assumed be recognized at their fair values as of the acquisition date. The preliminary valuation of the acquired assets and liabilities resulted in the recognition of identifiable assets of approximately $16.0 million comprised mainly of in-process research and development of approximately $15.4 million , deferred tax liabilities of $0.8 million and goodwill of approximately $1.4 million subject to final adjustments including tax related items. Various factors contributed to the establishment of goodwill, including an assembled workforce.
In connection with the Virttu transaction, we recorded acquisition costs of approximately $0.9 million in general and administrative expenses for the quarter ended June 30, 2017, for legal and related costs. Acquisition costs are expensed as incurred.
The purchase consideration, assets acquired, and liabilities assumed are preliminary and, as a result, are subject to change due to purchase price adjustments, additional information obtained related to fair value estimates, final tax adjustments and related items.
The acquisition of Virttu was not material to the Company's consolidated financial statements.
Acquisition of Scilex Pharmaceuticals Inc.
On November 8, 2016, the Company entered into a Stock Purchase Agreement (the “Scilex Purchase Agreement”) with Scilex and a majority of the stockholders of Scilex (the “Scilex Stockholders”) pursuant to which, on November 8, 2016, the Company acquired from the Scilex Stockholders, and the Scilex Stockholders sold to the Company, approximately 72% of the outstanding capital stock of Scilex (the “Scilex Acquisition”). The remainder of the outstanding capital stock of Scilex represents a noncontrolling interest of which approximately 23% continues to be held by ITOCHU CHEMICAL FRONTIER CORPORATION following the Scilex Acquisition.
Scilex focuses on the development and commercialization of specialty pharmaceutical products for the treatment of pain; its lead product, ZTlidoTM, is a branded lidocaine patch formulation being developed for the treatment of chronic pain. ZTlido™ (lidocaine patch 1.8%) will be manufactured by a contract manufacturer.
At the closing of the Scilex Acquisition, the Company issued to the Scilex Stockholders that were accredited investors (the “Accredited Scilex Stockholders”) consideration valued at $4.8 million , which consisted primarily of an aggregate of 754,911 shares of the Company’s common stock (the “Common Stock”).  Under the terms of the Scilex Purchase Agreement, the Company agreed to provide additional consideration to the Accredited Scilex Stockholders upon the achievement of certain milestones, as follows:
(1) Upon receipt of notice from the U.S. Food and Drug Administration (the “FDA”) that the FDA has accepted Scilex’s resubmitted new drug application for ZTlidoTM for the treatment of postherpetic neuralgia (the “NDA”), the Company will deliver to the Accredited Scilex Stockholders a number of shares of Common Stock equal to the quotient obtained by dividing 10% of the total undiscounted purchase consideration of approximately $47.8 million (the “Adjusted Base Consideration”) by a price (the “FDA Acceptance Price”) equal to the closing market price of one share of Common Stock, as reported by the Nasdaq Stock Market LLC (“Nasdaq”) on the date of Scilex’s receipt of the FDA notice or, if no closing price is reported for such date, the closing price on the last preceding date for which such quotation exists; provided, however, that in no event shall the FDA Acceptance Price be greater than $25.32 or less than $6.33 (in each case as adjusted, as appropriate, to reflect any stock splits or similar events affecting the Common Stock).
(2) Upon receipt of notice from the FDA that the FDA has approved the NDA for commercialization, the Company will deliver to the Accredited Scilex Stockholders cash and shares of Common Stock in such proportion to be determined in the

16



Company’s sole discretion, with a total value equal to 80% of the Adjusted Base Consideration (the “FDA Approval Consideration”). To the extent that the Company elects to pay any portion of the FDA Approval Consideration in shares of Common Stock, the number of shares shall be equal to the quotient obtained by dividing (a) the portion of the FDA Approval Consideration to be paid in shares of Common Stock by (b) a price (the “FDA Approval Price”) equal to the closing market price of one share of Common Stock, as reported by Nasdaq on the date of the Scilex’s receipt of the FDA notice or, if no closing price is reported for such date, the closing price on the last preceding date for which such quotation exists; provided, however, that in no event shall the FDA Approval Price be greater than $25.32 or less than $6.33 (in each case as adjusted, as appropriate, to reflect any stock splits or similar events affecting the Common Stock). However, in no event may the Company make an election with respect to the FDA Approval Consideration so as to cause the total number of shares of Common Stock issued in connection with the Scilex Acquisition to exceed 4.99% of the total number of shares of Common Stock of the Company outstanding as of immediately prior to the Closing (as adjusted, as appropriate, to reflect any stock splits or similar events affecting the Common Stock), unless the Company has obtained stockholder approval to issue a greater number of shares.
During the first quarter of 2017, the Company identified an error in the valuation of acquisition consideration associated with the Scilex Acquisition, primarily related to the acquisition consideration payable, resulting in an overstatement of acquisition consideration payable of $6.5 million , and a corresponding overstatement of intangible assets of $6.7 million , goodwill of $4.6 million , deferred income tax liability of $2.8 million , additional paid-in capital of $0.6 million , and noncontrolling interest of $1.4 million as of December 31, 2016. The Company evaluated the materiality of this misstatement from quantitative and qualitative perspectives, and concluded that it was immaterial to the prior periods. Consequently, the Company corrected this error by recording the adjustment in the Company’s condensed consolidated balance sheet in the quarter ended March 31, 2017.
At November 8, 2016, the contingent consideration was valued at $33.5 million , resulting in a total purchase consideration of approximately $38.2 million . The fair value of the contingent consideration is recorded as a current liability and will be periodically adjusted for changes in fair value or as events and circumstances arise. The remainder of the outstanding capital stock of Scilex represents a noncontrolling interest which was valued at $12.3 million at November 8, 2016.  
The consolidated financial statements include the results of operations from this transaction, which have been accounted for as a business combination, and require, among other things, that assets acquired and liabilities assumed be recognized at their fair values as of the acquisition date. The valuation of the acquired assets resulted in the recognition of identifiable assets of approximately $54.9 million comprised mainly of in-process research and development of $21.9 million and patents of $32.6 million .  The valuation of the acquired liabilities resulted in the recognition of liabilities of approximately $17.9 million comprised mainly deferred tax liabilities of $13.9 million .  The Company recorded goodwill of $13.5 million associated with the acquisition. The amounts in this footnote reflect the adjustment described above. Various factors contributed to the establishment of goodwill, including an assembled workforce. 
Acquired In-process Research and Development of BDL
In August 2015, the Company and TNK Therapeutics, Inc., its subsidiary (“TNK”),  entered into a Stock Purchase Agreement (the “Stock Purchase Agreement”) with BDL Products, Inc. (“BDL”) and the stockholders of BDL (“Stockholders”) pursuant to which the Stockholders sold all of their shares of capital stock in BDL to TNK for: (1) a cash payment of $100.00 , and (2)  $6.0 million in shares of TNK Class A Stock, subject to adjustment in certain circumstances, to be issued to the Stockholders upon a financing resulting in gross proceeds (individually or in the aggregate) to TNK of at least $50.0 million (a “Qualified Financing”).  In accordance with subsequent amendments to the Stock Purchase Agreement, in the event a Qualified Financing does not occur by October 15, 2017 (which is subject to further extension as implied and based on previously amended dates) or TNK does not complete an initial public offering of shares of its capital stock by September 15, 2017, in lieu of receiving shares of TNK pursuant to the acquisition, the Stockholders shall receive an aggregate of 309,917 shares of the Company’s common stock, subject to adjustment in certain circumstances.  
Acquired In-process Research and Development of Cargenix
In August 2015,  the Company and TNK entered into a Membership Interest Purchase Agreement (the “Membership Interest Purchase Agreement”) with CARgenix Holdings LLC (“CARgenix”) and the members of CARgenix (the “Members”) pursuant to which the Members sold all of their membership interests in CARgenix to TNK for: (1) a cash payment of $100.00 , and (2)  $6.0 million in shares of TNK Class A common stock (“TNK Class A Stock”), subject to adjustment in certain circumstances, to be issued to the Members upon a financing resulting in gross proceeds (individually or in the aggregate) to TNK of at least $50.0 million (a “Qualified Financing”). In accordance with an amendment to the Membership Interest Purchase Agreement entered into in March 2016, in the event a Qualified Financing did not occur by September 15, 2016 or TNK did not complete an initial public offering of shares of its capital stock by October 15, 2016, in lieu of receiving shares of

17



TNK pursuant to the acquisition, the Members would receive an aggregate of 309,917 shares of the Company’s common stock, subject to adjustment in certain circumstances and to account for fractional shares. TNK did not complete a Qualified Financing by the amended financing deadline and the Company issued 309,916 shares of its common stock to the Members on October 7, 2016.
5. Fair Value Measurements  
Fair value measurement is defined as the price that would be received to sell an asset or paid to transfer a liability in the principal or most advantageous market for the asset or liability in an orderly transaction between market participants at the measurement date. A fair value hierarchy is established, which prioritizes the inputs used in measuring fair value into three broad levels as follows:
Level 1—Quoted prices in active markets for identical assets or liabilities.
Level 2—Inputs, other than quoted prices in active markets, that are observable either directly or indirectly.
Level 3—Unobservable inputs based on the Company's own assumptions.
The following table presents the Company’s financial assets and liabilities that are measured at fair value on a recurring basis.  (in thousands):
 
Fair Value Measurements at June 30, 2017
 
Balance
 
Quoted Prices in Active Markets (Level 1)
 
Significant Other Observable Inputs (Level 2)
 
Significant Unobservable Inputs (Level 3)
Assets:
 

 
 

 
 

 
 

Cash and cash equivalents
$
53,681

 
$
53,681

 
$

 
$

Marketable securities
$
656

 
$
525

 
$

 
$
131

Total assets
$
54,337

 
$
54,206

 
$

 
$
131

Liabilities:
 

 
 

 
 

 
 

Acquisition consideration payable - Current
$
50,560

 
$

 
$

 
$
50,560

Acquisition consideration payable - Non-current
$
1,002

 
$

 
$

 
$
1,002

Total liabilities
$
51,562

 
$

 
$

 
$
51,562

 
 
 
 
 
 
 
 
 
Fair Value Measurements at December 31, 2016
 
Balance
 
Quoted Prices in Active Markets (Level 1)
 
Significant Other Observable Inputs (Level 2)
 
Significant Unobservable Inputs (Level 3)
Assets:
 

 
 

 
 

 
 

Cash and cash equivalents
$
82,398

 
$
82,398

 
$

 
$

Marketable securities
$
1,106

 
$
831

 
$

 
$
275

Total assets
$
83,504

 
$
83,229

 
$

 
$
275

Liabilities:
 

 
 

 
 

 
 

Acquisition consideration payable
$
48,362

 
$

 
$

 
$
48,362

Total liabilities
$
48,362

 
$

 
$

 
$
48,362

The Company's financial assets and liabilities carried at fair value are comprised of cash and cash equivalents, acquisition consideration payable and derivative instruments. Cash and cash equivalents consist of money market accounts and bank deposits which are highly liquid and readily tradable. These investments are valued using inputs observable in active markets for identical securities. Marketable securities are valued using inputs observable in active markets for identical securities. The Company recorded contingent consideration as part of its investment in Shanghai Three Alliance Biotech Co. LTD (“Shanghai Three”), agreement with Roger Williams Medical Center (“RWMC”), and acquisitions of Concortis, Inc., (“Concortis”), BDL, CARgenix, Scilex and Virttu. The fair value of the contingent consideration measured at fair value on a recurring basis using significant unobservable inputs (Level 3). Contingent consideration is measured using the income approach and discounting to present value the contingent payments expected to be made based on assessment of the probability that the company would be required to make such future payment.

18



The following table includes a summary of the Company’s contingent consideration liabilities and acquisition consideration payables associated with acquisitions. The contingent consideration is measured at fair value using significant unobservable inputs (Level 3) during the six months ended June 30, 2017 :
(in thousands)
 
Fair Value
Beginning Balance at December 31, 2016
 
48,362

Scilex acquisition adjustment (See Note 4)
 
(6,500
)
Acquisition consideration payable – current year acquisitions (See Note 4)
 
12,807

Contingent consideration (Non-current) – current year acquisitions (See Note 4)
 
983

Re-measurement of Fair Value
 
(4,090
)
Payment of current year contingent consideration
 

Ending Balance at June 30, 2017
 
$
51,562

The following table includes a summary of the Company’s contingent and financing liabilities, related inputs used to determine fair value, and the valuation methodologies used for the fair value measurements using significant unobservable inputs (Level 3) at June 30, 2017
(in thousands)
 
Fair Value Measurements at June 30, 2017
 
Valuation Methodology
 
Significant Unobservable Input
 
Weighted Average
(range, if applicable)
BDL Contingent Consideration
 
$
2,615

 
Multiple outcome
discounted cash flow
 
Discount Rate
Percent probabilities assigned to scenarios
 
11.07%
50%
Virttu Contingent Consideration (Non-current)
 
$
1,002

 
Multiple outcome
discounted cash flow
 
Discount Rate
Probability of Regulatory Milestone
 
12.21%
16%
Virttu Contingent Consideration
 
$
12,571

 
Multiple outcome
discounted cash flow
 
Discount Rate
Percent probabilities assigned to scenarios
 
3.82%
45% and 55%
Scilex Contingent Consideration
 
$
30,610

 
Monte Carlo simulation method
 
Discount Rate Probability of Regulatory Milestones
 
9.74%
100% and 95%
Concortis Contingent Consideration
 
$
557

 
Multiple outcome
discounted cash flow
 
Discount Rate
Percent probabilities assigned to scenarios
 
19.20%
20%
Shanghai Three Contingent Consideration
 
$
1,683

 
Multiple outcome
discounted cash flow
 
Discount Rate
Percent probabilities assigned to scenarios
 
12.21%
50%
RWMC Contingent Consideration
 
$
2,524

 
Multiple outcome
discounted cash flow
 
Discount Rate,
Percent probabilities assigned to scenarios
 
12.21%
50%
 
The principal significant unobservable inputs used in the valuations of the contingent considerations are the discount rates and probabilities assigned to scenario outcomes. An increase in the discount rate or regulatory milestone will cause a decrease in the fair value of the contingent consideration. Conversely, a decrease in the discount rate will cause an increase in the fair value of the contingent consideration. An increase in the probabilities assigned to certain scenarios will cause the fair value of contingent consideration to increase. Conversely, a decrease in the probabilities assigned to certain scenarios will cause the fair value of contingent considerations to decrease.
Fair Value of Other Financial Instruments

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The fair value of the debt obligation is measured at fair value using significant other observable inputs (Level 2) at June 30, 2017 . The carrying value and fair value of the Company’s debt obligations are as follows (in thousands):
 
 
June 30, 2017
 
 
Carrying Value
 
Fair Value
Debt Obligations:
 
 
 
 
Term Loan
 
26,541

 
26,541

 
 
 
 
 
Total Fair Value of Debt Obligations:
 
$
26,541

 
$
26,541

 
 
December 31, 2016
 
 
Carrying Value
 
Fair Value
Debt Obligations:
 
 
 
 
Term Loan
 
47,316

 
47,316

 
 
 
 
 
Total Fair Value of Debt Obligations:
 
$
47,316

 
$
47,316

6. Marketable Securities
Marketable securities consisted of the following as of June 30, 2017 and December 31, 2016 (in thousands):
 
June 30, 2017
 
Cost
 
Gross Unrealized Gains (Losses)
 
Gross Realized Gains (Losses)
 
Fair Value
Trading securities:
 

 
 

 
 

 
 

MedoveX common shares and warrants
$
750

 
$
(94
)
 
$

 
$
656

 
December 31, 2016
 
Cost
 
Gross Unrealized Gains (Losses)
 
Gross Realized Gains (Losses)
 
Fair Value
Trading securities:
 

 
 

 
 

 
 

MedoveX common shares and warrants
$
750

 
$
356

 
$

 
$
1,106

On August 5, 2016, the Company entered into a Unit Purchase Agreement (the “Unit Purchase Agreement”) with MedoveX Corporation (“MedoveX”). Pursuant to the terms of the Unit Purchase Agreement, the Company purchased three Units for $750,000 .  Each Unit had a purchase price of $250,000 and consisted of (i) 208,333 shares of MedoveX common stock (the “MedoveX Common Stock”), and (ii) a warrant to purchase 104,167 shares of MedoveX Common Stock (the “MedoveX Warrant”).  The MedoveX Warrant has an initial exercise price of $1.52 per share, subject to adjustment, and is initially exercisable six months following the date of issuance for a period of five years from the date of issuance.  In addition, the Company entered into a Registration Rights Agreement with MedoveX pursuant to which MedoveX was required to file a registration statement registering for resale all shares of MedoveX Common Stock and shares of MedoveX Common Stock issuable pursuant to the MedoveX Warrant issued as part of the Units. 
For the three months ended June 30, 2017 and 2016 , the Company recorded a loss of $0.6 million and $0 on trading securities. For the six months ended June 30, 2017 and 2016 , the Company recorded a loss of $0.5 million and $0 on trading securities. The Company’s investment in MedoveX will be revalued on each balance sheet date.  The fair value of the Company’s holding in MedoveX Common Stock at June 30, 2017 is a Level 1 measurement.  The fair value of the Company’s holdings in the MedoveX Warrant was estimated using the Black-Scholes option-pricing method. The risk-free rate was derived from the U.S. Treasury yield curve, matching the MedoveX Warrant’s term, in effect at the measurement date. The volatility factor was determined based on MedoveX’s historical stock prices. The warrant valuation is a Level 3 measurement.
The following table includes a summary of the warrant measured at fair value using significant unobservable inputs (Level 3) during the six months ended June 30, 2017 (in thousands):

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Total
Beginning balance at December 31, 2016
$
275

Change in fair value of warrant
(144
)
Ending balance at June 30, 2017
$
131

Available-for-sale Securities
On July 27, 2015, NantKwest, Inc. (“NantKwest”) completed its initial public offering (“IPO”).  Prior to the IPO, the Company’s investment in NantKwest was accounted for using the cost method and the total investment of $10.0 million was classified as part of investments in common stock on the Company’s consolidated balance sheets.  The common shares were subject to restrictions in a lock-up agreement through December 27, 2015 as well as limitations under Rule 144 of the Securities Act of 1933, as amended. As these were short term restrictions, the Company did not apply a marketability discount.  At December 31, 2015, the Company recorded an unrealized gain of $73.6 million , representing the difference between the $10.0 million cost basis and the estimated fair value net of tax, as accumulated other comprehensive income in the stockholder's equity section of the Company’s consolidated balance sheet and as a change in unrealized gains and losses on marketable securities in the Company’s consolidated statements of comprehensive income (loss). The Company’s investment in NantKwest was revalued on each balance sheet date.  The fair value of the Company’s holdings in NantKwest at December 31, 2015 was a Level 1 measurement.
In July 2016, the Company completed the transactions contemplated by a letter agreement (the “Letter Agreement”) with the Chan Soon-Shiong Family Foundation (“Foundation”) and Cambridge Equities, LP (“Cambridge”). Pursuant to the terms of the Letter Agreement, among other things, (i) the Company agreed to sell to Foundation, and Foundation agreed to purchase from the Company, an aggregate of 5,618,326 shares of common stock of NantKwest held by the Company (representing all shares of NantKwest held by the Company), (ii) Foundation agreed to sell to the Company, and the Company agreed to purchase all reported shares held by Foundation and Cambridge, constituting an aggregate of 7,878,098 shares of Common Stock, (iii) Cambridge agreed to forfeit its right to purchase 500,000 shares of Common Stock issuable pursuant to a warrant to purchase 1,724,138 shares of Common Stock issued by the Company, and (iv) the Company agreed to pay to Foundation an aggregate of approximately $15.6 million . Effective upon closing, the Company repurchased the 7,878,098 shares of Common Stock.  The Company recognized a gain of $27.2 million on the sale of the NantKwest stock in its consolidated statement of operations for the twelve months ended December 31, 2016 as a result of the transaction.
7. Property and Equipment
Property and equipment consisted of the following as of June 30, 2017 and December 31, 2016 (in thousands):
 
June 30,
2017
 
December 31,
2016
Furniture and fixtures
1,086

 
458

Office equipment
482

 
326

Machinery and lab equipment
17,481

 
13,220

Leasehold improvements
5,809

 
3,625

 
24,858

 
17,630

Less accumulated depreciation
(6,814
)
 
(4,922
)
 
$
18,044

 
$
12,707

Depreciation expense for the quarters ended June 30, 2017 and 2016 was $1.1 million and $0.4 million , respectively. Depreciation expense for the six months ended June 30, 2017 and 2016 was $1.9 million and $0.9 million , respectively.
8. Investments in Common Stock
As of June 30, 2017 and December 31, 2016 , the aggregate carrying amount of the Company’s cost-method investments in non-publicly traded companies was $112.0 million and included an ownership interest in NantCell, Inc. (“NantCell”), NantBioScience, Inc. (“NantBioScience”), Globavir Biosciences, Inc., Brink Biologics, Inc. and Coneksis, Inc. The Company’s cost-method investments are assessed for impairment quarterly. The Company has determined that it is not practicable to estimate the fair value of its cost-method investments on a regular basis and does not reassess the fair value of cost-method investments if there are no identified events or changes in circumstances that may have a significant adverse effect on the fair value of the investments.   No impairment losses were recorded during the three or six months ended June 30, 2017 .

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9 . Equity Method Investments  
NANTibody
In April 2015, the Company and NantCell, a wholly-owned subsidiary of NantWorks, Inc. (“NantWorks”), a private company owned by Dr. Patrick Soon-Shiong, established a new entity called Immunotherapy NANTibody, LLC (“NANTibody”) as a stand-alone biotechnology company with $100.0 million initial joint funding.  NantCell owns 60% of the equity interest of NANTibody and agreed to contribute $60.0 million to NANTibody.  The Company owns 40% of NANTibody and in July 2015, the Company had NantPharma, LLC (“NantPharma”) contribute its portion of the initial joint funding of $40.0 million to NANTibody from the proceeds of the sale of IgDraSol, Inc. (“IgDraSol”).  NANTibody will focus on accelerating the development of multiple immuno-oncology mAbs for the treatment of cancer, including but not limited to anti-PD-1, anti-PD-L1, anti-CTLA4mAbs, and other immune-check point antibodies as well as ADCs and bispecific antibodies.
The Company is accounting for its interest in NANTibody as an equity method investment, due to the significant influence the Company has over the operations of NANTibody through its board representation and 40% voting interest.  The Company’s investment in NANTibody is reported in equity method investments on its condensed consolidated balance sheets and its share of NANTibody’s loss is recorded in loss on equity investments on its condensed consolidated statement of operations.  As of June 30, 2017 , the carrying value of the Company’s investment in NANTibody was approximately $39.7 million .
The financial statements of NANTibody are not received sufficiently timely for the Company to record its portion of earnings or loss in the current financial statements and therefore the Company reports its portion of earnings or loss on a quarter lag.
NANTibody recorded net profit of $276 thousand and net loss of $1.5 million for the three months ended March 31, 2017 and December 31, 2016, respectively. NANTibody recorded net loss of $1.2 million for the six months ended March 31, 2017. The Company recorded its portion of loss from NANTibody in loss on equity investments on its condensed consolidated statement of operations for the three and six months ended June 30, 2017 and 2016 .  As of March 31, 2017, NANTibody had $100.0 million in current assets and $723 thousand in current liabilities and no noncurrent assets or noncurrent liabilities.
NantStem
In July 2015, the Company and NantBioScience, a wholly-owned subsidiary of NantWorks, established a new entity called NantCancerStemCell, LLC (“NantStem”) as a stand-alone biotechnology company with $100.0 million initial joint funding.  As initially organized, NantBioScience was obligated to make a $60.0 million cash contribution to NantStem for a 60% equity interest in NantStem, and the Company was obligated to make a $40.0 million cash contribution to NantStem for a 40% equity interest in NantStem.  Fifty percent of these contributions were funded in July 2015 and the remaining amounts were to be made by no later than September 30, 2015. The Company had NantPharma contribute its portion of the initial joint funding of $20.0 million to NantStem from the proceeds of the sale of IgDraSol.  Pursuant to a Side Letter dated October 13, 2015, the NantStem joint venture agreement was amended to relieve the Company of the obligation to contribute the second $20.0 million payment, and its ownership interest in NantStem was reduced to 20% .  NantBioScience’s funding obligations were unchanged.  The Side Letter was negotiated at the same time the Company issued a call option on shares of NantKwest that it owned to Cambridge Equities, a related party to NantBioScience (“Cambridge”).  
In the fourth quarter of 2015, the Company determined it had an other-than-temporary decline in the value of NantStem and recognized a loss of $4.0 million in loss on equity investments on its condensed consolidated statement of operations for the year ended December 31, 2015. There was no loss related to other-than-temporary impairment recognized for the equity investment for the year ended December 31, 2016 and the three and six months ended June 30, 2017 .
The Company is accounting for its interest in NantStem as an equity method investment, due to the significant influence the Company has over the operations of NantStem through its board representation and 20% voting interest.  The Company’s investment in NantStem is reported in equity method investments on its condensed consolidated balance sheets and its share of NantStem’s loss is recorded in loss on equity investments on its condensed consolidated statement of operations.  As of June 30, 2017 , the carrying value of the Company’s investment in NantStem was approximately $18.5 million . The difference between the Company’s investment in NantStem and the Company’s 20% interest in the net assets of Nantstem was approximately $2.2 million at June 30, 2017 .
The financial statements of NantStem are not received sufficiently timely for the Company to record its portion of earnings or loss in the current financial statements and therefore the Company reports its portion of earnings or loss on a quarter lag.

22



NantStem recorded net profit of $369 thousand and net loss of $455 thousand for the three months ended March 31, 2017 and December 31, 2016, respectively.  NantStem recorded net loss of $86 thousand for the six months ended March 31, 2017. The Company recorded its portion of loss from NANTibody in loss on equity investments on its condensed consolidated statement of operations for the three and six months ended June 30, 2017 and 2016 .  As of March 31, 2017, NantStem had $81.6 million in current assets and $28 thousand in current liabilities and no noncurrent assets or noncurrent liabilities.
Yuhan Agreement
In March 2016, the Company and Yuhan Corporation, a South Korea company (“Yuhan”), entered into an agreement to form a joint venture company called ImmuneOncia Therapeutics, LLC (“ImmuneOncia”) to develop and commercialize a number of immune checkpoint antibodies against undisclosed targets for both hematological malignancies and solid tumors.  Under the terms of the joint venture agreement, Yuhan contributed an initial investment of $10.0 million to ImmuneOncia, and the Company granted ImmuneOncia an exclusive license to one of its immune checkpoint antibodies for specified countries while retaining the rights for the U.S., European and Japanese markets, as well as global rights for ImmuneOncia to two additional antibodies that will be selected by ImmuneOncia from a group of pre-specified antibodies from the Company’s immuno-oncology antibody portfolio. During October 2016, funding and operations of ImmuneOncia commenced. Yuhan owns 51% of ImmuneOncia, while the Company owns 49% .
The Company is accounting for its interest in ImmuneOncia as an equity method investment, due to the significant influence the Company has over the operations of ImmuneOncia through its board representation and 49% voting interest while not sharing joint control with Yuhan.  The Company’s investment in ImmuneOncia is reported in equity method investments on its condensed consolidated balance sheets and its share of ImmuneOncia’s loss is recorded in loss on equity investments on its condensed consolidated statement of operations.  As of June 30, 2017 , the carrying value of the Company’s investment in ImmuneOncia was approximately $8.7 million . The difference between the Company’s investment in ImmuneOncia and the Company’s 49% interest in the net assets of ImmuneOncia was approximately $0.3 million at June 30, 2017.
ImmuneOncia recorded net loss of $1.0 million and $1.5 million for the three and six months ended June 30, 2017 , respectively.  The Company recorded its portion of loss from ImmuneOncia in loss on equity investments on its condensed consolidated statement of operations for the three and six months ended June 30, 2017 .  As of June 30, 2017 , ImmuneOncia had $8.5 million in current assets, $87 thousand in current liabilities, $9.9 million in noncurrent assets, and no noncurrent liabilities.
In April 2016, Yuhan purchased $10.0 million of shares of common stock, and warrants as part of the Company’s private placement offering.
Celularity Transaction
On November 1, 2016, the Company loaned $5.0 million to Celularity, Inc., a research and development company (“Celularity”), pursuant to a promissory note issued by Celularity to the Company, as amended (as so amended, the “Celularity Note”), in connection with the entry into a nonbinding term sheet by the Company, TNK and Celularity.  Pursuant to the terms of the Celularity Note, the loan will be due and payable in full on the earlier of November 1, 2017 and the occurrence of an event of default under the Celularity Note (the “Maturity Date”). In the event that Celularity meets certain minimum financing conditions prior to the Maturity Date, all outstanding amounts under the Celularity Note shall be forgiven and converted to equity. On May 31, 2017, the Company loaned an additional $2.0 million to Celularity pursuant to the terms of the Celularity Note. On June 14, 2017, the Company loaned an additional $1.0 million to Celularity, and the Company was obligated to loan an additional $2.0 million to Celularity by early July 2017. The loan is expected to be forgiven and converted to equity investment as part of the closing of the Contribution Agreement.
On June 12, 2017, the Company entered into a Contribution Agreement (the “Contribution Agreement”) with TNK and Celularity pursuant to which, among other things, the Company and TNK agreed to contribute certain intellectual property rights related to their proprietary chimeric antigen receptor (“CAR”) constructs and related CARs to Celularity in exchange for shares of Celularity’s Series A Preferred Stock equal to 25% of Celularity’s outstanding shares of capital stock, calculated on a fully-diluted basis. The contribution will be made pursuant to a License and Transfer Agreement to be entered into by and among the Company, TNK and Celularity.
As of June 30, 2017, the transactions contemplated by the Contribution Agreement had not closed.
The Company is accounting for its interest in Celularity as an equity method investment, due to the significant influence the Company has over the operations of Celularity through its minimum 25% voting interest.  The Company’s investment in Celularity is reported in equity method investments on the condensed consolidated balance sheets and its share of Celularity’s income or loss is recorded in income (loss) on equity investments on the condensed consolidated statement of operations. As of June 30, 2017 , the carrying value of the Company’s investment in Celularity was approximately $9.1 million .

23



The financial statements of Celularity are not received sufficiently timely for the Company to record its portion of earnings or loss in the current financial statements and therefore the Company reports its portion of earnings or loss on a quarter lag.
Celularity incurred operating expense of approximately $2.7 million for the three and six months ended March 31, 2017 in its interim financial results.
Shanghai Three
On March 7, 2016, TNK agreed to issue to SiniWest Holdings, Inc. (“SiniWest Holdings”) $4.0 million in shares of TNK Class A Stock, subject to certain circumstances, to be issued upon a financing resulting in gross proceeds (individually or in the aggregate) to TNK of at least $10.0 million and a $1.0 million upfront cash payment in exchange for SiniWest Holdings transferring certain assets to TNK, including SiniWest Holdings’ 25% interest in Shanghai Three-Alliance Biotech Co. LTD, a China based company (“Shanghai Three”). The Company is accounting for its interest in Shanghai Three as an equity method investment, due to the significant influence the Company has over the operations of Shanghai Three through its 25% voting interest.  The Company’s investment in Shanghai Three is reported in equity method investments on the condensed consolidated balance sheets and its share of Shanghai Three’s income or loss is recorded in income (loss) on equity investments on the condensed consolidated statement of operations.  As of June 30, 2017 , the carrying value of the Company’s investment in Shanghai Three was approximately $3.8 million
The financial statements of Shanghai Three are not received sufficiently timely for the Company to record its portion of earnings or loss in the current financial statements and therefore the Company reports its portion of earnings or loss on a quarter lag. 
Shanghai Three incurred no operating expenses for the three and six months ended March 31, 2017.  As of March 31, 2017, Shanghai Three had $0.4 million in current assets, $2.9 million in current liabilities, $5.3 million in noncurrent assets, and $5.0 million in noncurrent liabilities. 
3SBio Term Sheet
In June 2016, the Company and TNK entered into a joint venture agreement with Shenyang Sunshine Pharmaceutical Company Ltd (“3SBio”), a China based company, to develop and commercialize proprietary immunotherapies, including those developed from, including or using TNK’s “CAR-T” technology targeting carcinoembryonic antigen (“CEA”) positive cancers.  Due diligence and negotiations between 3SBio and the Company for the definitive agreement(s) are currently ongoing.
Under the terms of the agreement 3SBio will contribute an initial investment of $10.0 million to the joint venture and TNK will grant the joint venture an exclusive license to the CEA CAR-T technology and two additional CARs for cellular therapy for the Greater China market, including Mainland China, Hong Kong and Macau. 3SBio will own 51% of the joint venture while TNK will own 49% .  As of June 30, 2017 , funding and operations of the joint venture had not yet begun, as a result no investment has been recorded as of June 30, 2017 .
In June 2016, 3SBio purchased $10.0 million of shares of common stock and warrants as part of the Company’s private placement offering.

24



10. Goodwill and Intangible Assets
 At June 30, 2017 , the Company had recorded goodwill of $38.3 million , which reflects the adjustment described in Note 4. At December 31, 2016 , the Company had recorded goodwill of $41.5 million .  The Company performed a qualitative test for goodwill impairment as of December 31, 2016 . Based upon the results of the qualitative testing the Company concluded that it is more-likely-than-not that the fair values of the Company’s goodwill was in excess of its carrying value and therefore performing the first step of the two-step impairment test was unnecessary. No goodwill impairment was recognized for the three and six months ended June 30, 2017 and 2016 . A summary of the Company's goodwill as of June 30, 2017, including the impact of acquisitions described in Note 4 is as follows (in thousands):
 
Total
Balance at December 31, 2016
$
41,548

    Scilex Acquisition Adjustment
(4,645
)
    Goodwill Acquired from Virttu Acquisition
1,384

    Foreign Currency Translation Adjustments
$
11

Balance at June 30, 2017
$
38,298


The Company’s intangible assets, excluding goodwill, include acquired license and patent rights, core technologies, customer relationships and acquired in-process research and development. Amortization for the intangible assets that have finite useful lives is generally recorded on a straight-line basis over their useful lives.  A summary of the Company’s identifiable intangible assets as of June 30, 2017 , including the adjustment described in Note 4, and December 31, 2016 is as follows (in thousands):
 
June 30, 2017
 
Gross Carrying Amount
 
Accumulated Amortization
 
Intangibles, net
Customer relationships
$
1,585

 
$
946

 
$
639

Acquired technology
3,410

 
621

 
2,789

Acquired in-process research and development
37,660

 

 
37,660

Patent rights
32,720

 
1,478

 
31,242

Total intangible assets
$
75,375

 
$
3,045

 
$
72,330

 
December 31, 2016
 
Gross Carrying Amount
 
Accumulated Amortization
 
Intangibles, net
Customer relationships
$
1,585

 
$
801

 
$
784

Acquired technology
3,410

 
533

 
2,877

Acquired in-process research and development
25,404

 

 
25,404

Patent rights
36,120

 
419

 
35,701

Total intangible assets
$
66,519

 
$
1,753

 
$
64,766

As of June 30, 2017 , the remaining weighted average life for identifiable intangible assets is 15 years .
Patent rights are stated at cost and amortized on a straight-line basis over the estimated useful lives of the assets, determined to be approximately fifteen years or nineteen years from the date of transfer of the rights to the Company. Amortization expense for the three months ended June 30, 2017 and 2016 was $552 thousand and $1 thousand , respectively, which has been included in intangible amortization on the condensed consolidated statement of operations. Amortization expense for the six months ended June 30, 2017 and 2016 was $1,059 thousand and $3 thousand , respectively, which has been included in intangible amortization on the condensed consolidated statement of operations.
Acquired technology is stated at cost and depreciated on a straight-line basis over the estimated useful lives of the assets, determined to be approximately 19 years from the date of acquisition of the technology in December 2013. Amortization expense for both the three months ended June 30, 2017 and 2016 was $44 thousand , which has been included in intangibles amortization. Amortization expense for each of the six months ended June 30, 2017 and 2016 was $88 thousand , which has been included in intangible amortization on the condensed consolidated statement of operations.

25



Customer relationships are stated at cost and depreciated on a straight-line basis over the estimated useful lives of the assets, determined to be approximately five years from the date of acquisition. Amortization expense for the three months ended June 30, 2017 and 2016 , was $73 thousand and $66 thousand , respectively, which has been included in intangibles amortization. Amortization expense for the six months ended June 30, 2017 and 2016 was $145 thousand and $132 thousand , respectively, which has been included in intangible amortization on the condensed consolidated statement of operations.
Acquired in-process research and development is stated at cost and may be immediately expensed if there is no alternative future use. Otherwise, the acquired in-process research and development is reviewed annually for impairment or more frequently as changes in circumstance or the occurrence of events suggest that the remaining value may not be recoverable.
Estimated future amortization expense related to intangible assets at June 30, 2017 is as follows (in thousands):
Years Ending December 31,
 
Amount
2017
 
$
1,368

2018
 
3,747

2019
 
3,858

2020
 
3,858

2021
 
5,053

Thereafter
 
54,446

Total
 
$
72,330

11. Significant Agreements and Contracts
License Agreement with Les Laboratoires Servier
On July 11, 2016, the Company announced a license and collaboration agreement with Les Laboratoires Servier, SAS, a corporation incorporated under the laws of France, and Institut de Recherches Internationales Servier, a company duly organized and existing under the laws of France (individually and collectively, “Servier”) for the development, manufacture and commercialization of products using the Company’s fully human immuno-oncology anti-PD-1mAb STI-A1110 and will provide support for Servier’s initial development efforts. Pursuant to the financial terms of the agreement, the Company received a non-refundable up-front payment of $27.4 million in July 2016, which has been recorded as deferred revenue in the Company’s condensed consolidated balance sheet and may also receive various payments based on commercial sales milestones related to annual sales levels.  The Company will recognize the upfront payment over the expected period of performance of three years .  During the quarter ended June 30, 2017 , the Company recognized $2.3 million in license fee revenue pursuant to the agreement. During the six months ended June 30, 2017 , the Company recognized $4.6 million in license fee revenue pursuant to the agreement.
License Agreement with Mabtech Limited
In August 2015, the Company entered into an exclusive licensing agreement to develop and commercialize multiple prespecified biosimilar and biobetter antibodies from Mabtech Limited.  Under the terms of the agreement, the Company will develop and market these four mAbs for the North American, European and Japanese markets. The Company made an initial license payment of $10.0 million and in February 2016, paid an additional $10.0 million license payment, both of which were recognized as acquired in-process research and development expense in the condensed consolidated statements of operations as the Company determined there was no alternative future use for the license.  
In June 2016, the Company agreed to accelerate and pay a $30.0 million milestone license payment which has been recognized as acquired in-process research and development expense in the condensed consolidated statements of operations, in exchange for the purchase by Mabtech Limited and one or more of its affiliates in June 2016, of $20.0 million of shares of common stock and warrants.  The amended agreement includes additional milestone payments totaling $150.0 million payable following the completion of the technology transfer from Mabtech Limited.
Immunotherapy Research Collaboration Agreement with Roger Williams Medical Center
In April 2016, the Company entered into an immunotherapy research collaboration agreement with Roger Williams Medical Center to provide certain clinical trial, research and manufacturing services. Under the terms of the agreement, Roger Williams Medical Center will perform pre-clinical and clinical research related to the development and delivery of CAR-T immunotherapies. In exchange, the Company granted Roger Williams Medical Center $6.0 million in shares of TNK Class A

26



Stock, subject to adjustment in certain circumstances, to be issued upon a financing resulting in gross proceeds (individually or in the aggregate) to TNK of at least $20.0 million .  The Company determined the fair value of this obligation was $3.4 million as of the April of 2016 agreement effective date, and the amount was recognized as prepaid expense and other and acquisition consideration payable in the condensed consolidated balance sheet.  The Company will recognize the upfront payment over the expected performance period of five years . During the quarter ended June 30, 2017 and 2016 , the Company recognized approximately $170 thousand and $113 thousand in pre-clinical research and development expense pursuant to the agreement, respectively. During the six months ended June 30, 2017 and 2016 , the Company recognized approximately $340 thousand and $113 thousand in pre-clinical research and development expense pursuant to the agreement, respectively.
License Agreement with NantCell
In April 2015, the Company and NantCell entered into a license agreement. Under the terms of the agreement the Company granted an exclusive license to NantCell covering patent rights, know-how, and materials related to certain antibodies, ADCs and two CAR-TNK products.  NantCell agreed to pay a royalty not to exceed five percent ( 5% ) to the Company on any net sales of products (as defined) from the assets licensed by the Company to NantCell.  In addition to the future royalties payable under this agreement, NantCell paid an upfront payment of $10.0 million to the Company and issued 10 million shares of NantCell common stock to the Company valued at $100.0 million based on a recent equity sale of NantCell common stock to a third party.  As of June 30, 2017 , the Company had not yet provided all of the items noted in the agreement and therefore has recorded the entire upfront payment and value of the equity interest received as deferred revenue.  The Company will recognize the upfront payment and the value of the equity interest received over the expected license period of approximately ten years on a straight-line basis.  The Company’s ownership interest in NantCell does not provide the Company with control or the ability to exercise significant influence; therefore the $100.0 million investment is carried at cost in the condensed consolidated balance sheets and evaluated for other-than-temporary impairment on a quarterly basis.
License Agreement with The Scripps Research Institute
In January 2010, the Company entered into a license agreement (the “TSRI License”) with The Scripps Research Institute (“TSRI”). Under the TSRI License, TSRI granted the Company an exclusive, worldwide license to certain TSRI patent rights and materials based on quorum sensing for the prevention and treatment of Staphylococcus aureus (“Staph”) infections, including Methicillin-resistant Staph. In consideration for the license, the Company: (i) issued TSRI a warrant for the purchase of common stock, (ii) agreed to pay TSRI a certain annual royalty commencing in the first year after certain patent filing milestones are achieved and (iii) agreed to pay a royalty on any sales of licensed products by the Company or its affiliates and a royalty for any revenues generated by the Company through its sublicense of patent rights and materials licensed from TSRI under the TSRI License. The TSRI License requires the Company to indemnify TSRI for certain breaches of the agreement and other matters customary for license agreements. The parties may terminate the TSRI License at any time by mutual agreement. In addition, the Company may terminate the TSRI License by giving 60 days ’ notice to TSRI and TSRI may terminate the TSRI License immediately in the event of certain breaches of the agreement by the Company or upon the Company’s failure to undertake certain activities in furtherance of commercial development goals. Unless terminated earlier by either or both parties, the term of the TSRI License will continue until the final expiration of all claims covered by the patent rights licensed under the agreement. For the quarters ended June 30, 2017 and 2016 , the Company recorded $14 thousand and $2 thousand in patent prosecution and maintenance costs associated with the TSRI License, respectively. For the six months ended June 30, 2017 and 2016 , the Company recorded $41 thousand and $22 thousand in patent prosecution and maintenance costs associated with the TSRI License, respectively. All such costs have been included in general and administrative expenses.
NIH Grants
In June 2014, the NIAID awarded the Company a Phase II Small Business Technology Transfer (“STTR”) grant (the “Staph Grant III Award”) to support the advanced preclinical development of human bispecific antibody therapeutics to prevent and treat Staphylococcus aureus (“ S. aureus ” or “Staph”) infections, including methicillin-resistant S. aureus (“MRSA”). The project period for the Staph Grant III Award covered a two -year period which commenced in June 2014, which was subsequently extended by one year , with total funds available of approximately $1.0 million per year for up to two years. During each of the quarters ended June 30, 2017 and 2016 , the Company recorded $94 thousand and $218 thousand of revenue associated with the Staph Grant III Award, respectively. During the six months ended June 30, 2017 and 2016 , the Company recorded $195 thousand and $457 thousand of revenue associated with the Staph Grant III Award, respectively.
Binding Term Sheet Regarding Acquisition of Semnur Pharmaceuticals, Inc.
On August 15, 2016, the Company’s subsidiary, Scintilla Pharmaceuticals, Inc. (“Scintilla”) and Semnur Pharmaceuticals, Inc. (“Semnur”) entered into a binding term sheet (the “Semnur Binding Term Sheet”) setting forth the terms and conditions by which Scintilla will, through a subsidiary, purchase all of the issued and outstanding equity of Semnur (the

27



“Semnur Acquisition”). The Semnur Binding Term Sheet provides that, contingent upon the execution of a definitive agreement between the parties (the “Definitive Agreement”) and subject to certain conditions, Scintilla will, at the closing of the Semnur Acquisition (the “Semnur Closing”), make an initial payment of $60.0 million (the “Initial Consideration”) to the equityholders of Semnur in exchange for all of the issued and outstanding equity of Semnur. The Initial Consideration will consist of $40.0 million in cash and $20.0 million in shares of the Company’s common stock (the “Semnur Stock Consideration”). The Semnur Binding Term Sheet also provides that the number of shares of the Company’s common stock comprising the Semnur Stock Consideration will be calculated based on the volume weighted average closing price of the Company’s common stock for the 30 consecutive trading days ending on the date that is three days prior to the execution of the Definitive Agreement. $6.0 million of the Semnur Stock Consideration will be placed into escrow, a portion of which will be held for a period of up to six or 12 months to secure certain obligations of Semnur and its equityholders in connection with the Semnur Acquisition. At the Semnur Closing, the Company will enter into a registration rights agreement with certain of Semnur’s equityholders, pursuant to which the Company will agree to seek the registration for resale of the shares of the Company’s common stock comprising the Semnur Stock Consideration.
In addition to the Initial Consideration, Scintilla may pay additional consideration of up to $140.0 million to Semnur’s equityholders upon Scintilla’s completion of certain clinical studies and trials, receipt of certain regulatory approvals and the achievement of certain sales targets following the Semnur Closing.
Under the Semnur Binding Term Sheet, either party may terminate the Semnur Binding Term Sheet.
As of June 30, 2017 , the Semnur Acquisition had not closed. The final terms of the Semnur Acquisition are subject to the negotiation and finalization of the Definitive Agreement and any other agreements relating to the Semnur Acquisition, and the material terms of the Semnur Acquisition are expected to differ from those set forth in the Semnur Binding Term Sheet. In addition, the Semnur Closing will be subject to various customary and other closing conditions.
A member of the Company’s board of directors is Semnur’s Chief Executive Officer and a member of its Board of Directors and currently owns approximately 5.5% of Semnur’s total outstanding capital stock.

28



12. Loan and Security Agreement
In September 2013, the Company entered into a $5.0 million loan and security agreement with two banks pursuant to which: (i) the lenders provided the Company a term loan which was funded at closing, (ii) the Company repaid its then outstanding equipment loan balance of $762,000 , and (iii) the lenders received a warrant to purchase an aggregate 31,250 shares of the Company’s common stock at an exercise price of $8.00 per share exercisable for seven years from the date of issuance. The value of the warrants, totaling $215 thousand , was recorded as debt discount and additional paid-in capital.
In March 2014, the Company entered into an amended and restated loan and security agreement, increasing the September 2013 facility to $12.5 million from $5.0 million , with the same two banks. Such loan was funded at closing and is secured by a lien covering substantially all of the Company’s assets, excluding intellectual property, which is subject to a negative pledge. In October 2014, the Company entered into a second amendment to its amended and restated loan and security agreement to extend the interest only payments on the outstanding amount of the loan from October 1, 2014 to May 1, 2015, after which equal monthly payments of principal and interest are due until the loan maturity date of September 30, 2017 . The amended and restated loan: (i) provided for an interest rate of 7.95%  per annum, and (ii) provided the lenders additional warrants to purchase an aggregate of 34,642  shares of the Company’s common stock at an exercise price of $12.99  per share, exercisable for seven years from the date of issuance. The value of the warrants, totaling $322 thousand , was recorded as debt discount and additional paid-in capital.
On November 22, 2016, the Company paid off all obligations owing under, and terminated, the amended and restated loan and security agreement, as amended (the “Terminated Loan Agreement”). In connection with the repayment and discharge of indebtedness, the Company was required to pay pre-payment fees of approximately $49 thousand . The secured interests under the Terminated Loan Agreement were terminated in connection with the Company’s discharge of indebtedness.
On November 23, 2016, the Company and certain of its domestic subsidiaries (together with the Company, the “Borrowers”) entered into a Loan and Security Agreement (the “Loan Agreement”) with Hercules Capital, Inc. (“Hercules”), as a lender and agent for several banks and other financial institutions or entities from time to time party to the Loan Agreement (collectively, the “Lenders”) for a term loan of up to $75.0 million , subject to funding in multiple tranches (the “Term Loan”). The Term Loan will mature on December 1, 2020 . The proceeds of the Term Loan will be used for general corporate purposes and coincided with the repayment of the outstanding debt financing arrangement with Oxford Finance LLC and Silicon Valley Bank.
The first tranche of $50.0 million was funded upon execution of the Loan Agreement on November 23, 2016. Under the terms of the Loan Agreement, the Borrowers may, but are not obligated to, request additional funds of up to $25.0 million which are available until June 30, 2018 , subject to approval by Hercules’ Investment Committee. Pursuant to the terms of the third amendment to the Loan Agreement entered into on March 15, 2017, the Company paid Hercules $1.5 million for a portion of the backend fee. Pursuant to the terms of the fourth amendment to the Loan Agreement entered into on March 23, 2017 (the “Fourth Amendment”), the Company repaid Hercules, without repayment penalty, $20.0 million of the outstanding principal and unpaid interest accrued thereon on March 23, 2017.  The Fourth Amendment also provided for the following: (1) Hercules reduced the minimum amount of unrestricted cash that the Company must maintain under the Loan Agreement, and (2) the parties agreed to change the date by which the Company must achieve a fundraising milestone.
The Loan Agreement contains customary affirmative and restrictive covenants and representations and warranties, including financial reporting obligations and significant limitations on dividends, indebtedness, liens (including a negative pledge on intellectual property and other assets), collateral, investments, distributions, transfers, mergers or acquisitions, taxes, corporate changes, deposit accounts, and subsidiaries. Additionally, the Loan Agreement contains covenants requiring the Borrowers (i) to achieve certain fundraising requirements by certain dates and (ii) to maintain $20.0 million of unrestricted cash prior to achieving its corporate and fundraising milestones. The Company's public offering for net proceeds of $43.5 million satisfied the fundraising requirements and fundraising milestone. The breach of certain covenants under the Loan Agreement would result in the occurrence of an event of default. The Loan Agreement also contains other customary provisions, such as expense reimbursement, non-disclosure obligations, as well as indemnification rights for the benefit of the Lenders. Upon the occurrence of an event of default and following any applicable cure periods, if any, a default interest rate of an additional 5.00% may be applied to the outstanding loan balances, and the Lenders may declare all outstanding obligations immediately due and payable and take such other actions as set forth in the Loan Agreement.
In connection with the Loan Agreement, the Company issued Hercules a warrant, dated November 23, 2016 (the “Warrant”), to purchase up to 460,123 shares of Common Stock, at an initial exercise price of $4.89 , subject to adjustment as provided in the Warrant. The Warrant is initially exercisable for 306,748 shares of common stock of the Company, and may automatically become exercisable for additional shares of common stock on such dates (if any) based upon the funding amounts of any additional tranches of the Term Loan that may be extended to the Borrowers. The Warrant will terminate, if not

29



earlier exercised, on the earlier of November 23, 2023 and the closing of certain merger or other transactions in which the consideration is cash, stock of a publicly-traded acquirer or a combination thereof.
Long-term debt and unamortized discount balances are as follows (in thousands):
Face value of loan
$
50,000

Repayment principal and backend fee
(21,500
)
Fair value of warrant
(1,377
)
Capitalized debt issuance costs
(1,681
)
Accretion of debt issuance costs and other
840

Accretion of debt discount
259

Balance at June 30, 2017
26,541

Future minimum payments under the amended and restated loan and security agreement are as follows (in thousands):
Year Ending December 31,
 
2017
1,522

2018
8,322

2019
13,612

2020
14,935

Total future minimum payments
38,391

Unamortized interest
(8,792
)
Debt discount
(1,377
)
Capitalized debt issuance costs
(1,681
)
Total minimum payment
26,541

Current portion

Long-term debt
$
26,541

13. Stock Incentive Plans
2009 Non-Employee Director Grants
In September 2009, prior to the adoption of the 2009 Stock Incentive Plan, the Company’s Board of Directors approved the reservation and issuance of 8,000 non-statutory stock options to the Company’s non-employee directors. The options vested on the one year anniversary of the vesting commencement date in October 2010, and are exercisable for up to ten years from the grant date. No further shares may be granted under this plan and, as of June 30, 2017 , 3,200 options with a weighted-average exercise price of $1.12 were outstanding.
2009 Stock Incentive Plan
In October 2009, the Company’s stockholders approved the 2009 Stock Incentive Plan. In July 2017, the Company’s stockholders approved, among other items, the amendment and restatement of the 2009 Stock Incentive Plan (as amended and restated, the “Stock Plan”) to increase the number of shares of the Company’s common stock authorized to be issued pursuant to the Stock Plan to 11,260,000 . Such shares of the Company’s common stock are reserved for issuance to employees, non-employee directors and consultants of the Company. The Stock Plan provides for the grant of incentive stock options, non-incentive stock options, stock appreciation rights, restricted stock awards, unrestricted stock awards, restricted stock unit awards and performance awards to eligible recipients. Recipients of stock options shall be eligible to purchase shares of the Company’s common stock at an exercise price equal to no less than the estimated fair market value of such stock on the date of grant. The maximum term of options granted under the Stock Plan is ten years . Employee option grants generally vest 25% on the first anniversary of the original vesting commencement date, with the balance vesting monthly over the remaining three years . The vesting schedules for grants to non-employee directors and consultants will be determined by the Company’s Compensation Committee. Stock options are generally not exercisable prior to the applicable vesting date, unless otherwise accelerated under the terms of the applicable stock plan agreement.

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The following table summarizes stock option activity as of June 30, 2017 and the changes for the period then ended (dollar values in thousands):
 
Options
Outstanding
 
Weighted-
Average
Exercise Price
 
Aggregate
Intrinsic
Value
Outstanding at December 31, 2016
4,332,876

 
$
7.86

 
$
427

Options Granted
53,300

 
$
5.20

 
 

Options Canceled
(10,900
)
 
$
9.17

 
 

Options Exercised

 
$

 
 

Outstanding at June 30, 2017
4,375,276

 
$
7.83

 
$
5

The aggregate intrinsic value of options exercised during the three months ended June 30, 2017 and 2016 were $0 and $66 thousand , and $0 and $150 thousand during the six months ended June 30, 2017 and 2016, respectively.  The Company uses the Black-Scholes valuation model to calculate the fair value of stock options. The fair value of employee stock options was estimated at the grant date using the following assumptions:
 
Six Months Ended June 30,
 
2017
 
2016
Weighted-average grant date fair value
$
5.20

 
$
5.79

Dividend yield
%
 
%
Volatility
64
%
 
75
%
Risk-free interest rate
2.16
%
 
1.45
%
Expected life of options
6.1 years

 
6.1 years

The assumed dividend yield was based on the Company’s expectation of not paying dividends in the foreseeable future. Due to the Company’s limited historical data, the estimated volatility incorporates the historical and implied volatility of comparable companies whose share prices are publicly available. The risk-free interest rate assumption was based on the U.S. Treasury’s rates for U.S. Treasury zero-coupon bonds with maturities similar to those of the expected term of the award being valued. The weighted average expected life of options was estimated using the average of the contractual term and the weighted average vesting term of the options.
The total employee and director stock-based compensation recorded as operating expenses was $1.2 million and $1.0 million for the three months ended June 30, 2017 and 2016 , and $2.5 million and $2.1 million for the six months ended June 30, 2017 and 2016 , respectively.
The total unrecognized compensation cost related to unvested employee and director stock option grants as of June 30, 2017 was $7.8 million and the weighted average period over which these grants are expected to vest is 2.8 years .
The Company records equity instruments issued to non-employees as expense at their fair value over the related service period as determined in accordance with the authoritative guidance and periodically revalues the equity instruments as they vest. Stock-based compensation expense related to non-employee consultants recorded as operating expenses was $8 thousand and $44 thousand for the three months ended June 30, 2017 and 2016 , respectively, and $34 thousand and $96 thousand for the six months ended June 30, 2017 and 2016 , respectively.

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Common Stock Reserved for Future Issuance
Common stock reserved for future issuance consists of the following at June 30, 2017 :
Common stock warrants outstanding under the underwriters agreement
182,600

Common stock warrants outstanding under the loan and security agreement
65,892

Common stock warrants outstanding under the Cambridge securities agreement
1,224,138

Common stock warrants outstanding under the Hercules securities agreement
306,748

Common stock warrants outstanding under private placements
4,153,620

Common stock options outstanding under the Non-Employee Director Plan
3,200

Authorized for future grant or issuance under the 2009 Stock Incentive Plan
1,406,820

Issuable under BDL acquisition agreement
309,916

Issuable under Scilex acquisition agreement
754,947

Issuable under Virttu acquisition agreement
3,603,604

Issuable under assignment agreement based upon achievement of certain milestones
80,000

 
12,091,485

 
2017 Stock Option Plans
In June 2017, the Company’s subsidiary, Scilex, adopted the Scilex 2017 Stock Option Plan, reserved 4.0 million shares of Scilex common stock and awarded 1.0 million options to certain Company personnel, directors and consultants under such plan.   Stock options granted under this plan typically vest 1/4th of the shares on the first anniversary of the vesting commencement date and 1/48th of the remaining options vest each month thereafter. As of June 30, 2017 , 1.0 million options were outstanding.
2015 Stock Option Plans
In May 2015, the Company’s subsidiary, TNK, adopted the TNK 2015 Stock Option Plan, reserved 10.0 million shares of TNK class A common stock and awarded 3.6 million options to certain Company personnel, directors and consultants under such plan. In November 2015, TNK awarded 0.5 million options to certain Company personnel.  Stock options granted under this plan typically vest a portion immediately upon grant and the remaining options over two to four years or monthly over four years from the grant date and have a contractual term of ten years . As of June 30, 2017 , 3.0 million options were outstanding.
In May 2015, TNK granted a warrant to the Company’s CEO to purchase 9.5 million shares of TNK class B common stock, which have 10 to 1 voting rights.  Warrant shares totaling 4.0 million are exercisable evenly over forty months and the remaining warrant shares are exercisable if certain defined events occur within four years from date of issuance at an initial exercise price of $0.01 per share.  The exercise price of the warrant is subject to customary adjustment provisions for stock splits, stock dividends, recapitalizations and the like.
In May 2015, the Company’s subsidiary, LA Cell, Inc. (“LA Cell”), adopted the LA Cell 2015 Stock Option Plan reserved 10.0 million shares of LA Cell class A common stock and awarded 2.9 million options to certain Company personnel, directors and consultants under such plan. Stock options granted under this plan typically vest a portion immediately upon grant and the remaining options over two to four years or monthly over four years from the grant date and have a contractual term of ten years . As of June 30, 2017 , 2.1 million options were outstanding.
In May 2015, LA Cell granted a warrant to the Company’s CEO to purchase 9.5 million shares of LA Cell class B common stock, which have 10 to 1 voting rights.  Warrant shares totaling 4.0 million are exercisable evenly over forty months and the remaining warrant shares are exercisable if certain defined events occur within four years from date of issuance at an initial exercise price of $0.01 per share.  The exercise price of the warrant is subject to customary adjustment provisions for stock splits, stock dividends, recapitalizations and the like.  
In October 2015, the Company’s subsidiary, Concortis Biosystems, Corp. (“CBC”), adopted the CBC 2015 Stock Option Plan and reserved 10.0 million shares of CBC class A common stock and awarded 1.8 million options to certain Company personnel, directors and consultants under such plan. Stock options granted under this plan typically vest a portion immediately upon grant and the remaining options over two to four years or monthly over four years from the grant date and have a contractual term of ten years . As of June 30, 2017 , 1.8 million options were outstanding.
In October 2015, CBC granted a warrant to the Company’s CEO to purchase 9.5 million shares of CBC class B common stock, which have 10 to 1 voting rights.  Warrant shares totaling 4.0 million are exercisable evenly over forty months and the

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remaining warrant shares are exercisable if certain defined events occur within four years from date of issuance at an initial exercise price of $0.25 per share.  The exercise price of the warrant is subject to customary adjustment provisions for stock splits, stock dividends, recapitalizations and the like.
In October 2015, the Company’s subsidiary, Scintilla, adopted the Scintilla 2015 Stock Option Plan, reserved 10.0 million shares of Scintilla class A common stock. and awarded 2.1 million options to certain Company personnel, directors and consultants under such plan.   Stock options granted under this plan typically vest a portion immediately upon grant and the remaining options over two to four years or monthly over four years from the grant date and have a contractual term of ten years . As of June 30, 2017 , 1.0 million options were outstanding.
In October 2015, Scintilla granted a warrant to the Company’s CEO to purchase 9.5 million shares of Scintilla class B common stock, which have 10 to 1 voting rights.  Warrant shares totaling 4.0 million are exercisable evenly over forty months and the remaining warrant shares are exercisable if certain defined events occur within four years from date of issuance at an initial exercise price of $0.01 per share.  The exercise price of the warrant is subject to customary adjustment provisions for stock splits, stock dividends, recapitalizations and the like.
In October 2015, the Company’s subsidiary, Sorrento Biologics, Inc. (“Biologics”), adopted the Biologics 2015 Stock Option Plan, reserved 10.0 million shares of Biologics class A common stock and awarded 2.6 million options to certain Company personnel, directors and consultants under such plan.  Stock options granted under this plan typically vest a portion immediately upon grant and the remaining options over two to four years or monthly over four years from the grant date and have a contractual term of ten years . As of June 30, 2017 , 1.4 million options were outstanding
In October 2015, Biologics granted a warrant to the Company’s CEO to purchase 9.5 million shares of Biologics class B common stock which have 10 to 1 voting rights.  Warrant shares totaling 4.0 million are exercisable evenly over forty months and the remaining warrant shares are exercisable if certain defined events occur within four years from date of issuance at an initial exercise price of $0.01 per share.  The exercise price of the warrant is subject to customary adjustment provisions for stock splits, stock dividends, recapitalizations and the like.
The total director stock-based compensation recorded as operating expenses by the Company for TNK, LA Cell, CBC, Scintilla and Biologics for the three months ended June 30, 2017 and 2016 was $54 thousand and $41 thousand , respectively and was $96 thousand and $83 thousand for the six months ended June 30, 2017 and 2016, respectively. Total unrecognized stock-based compensation expense related to unvested director stock option and warrant grants for these entities as of June 30, 2017 was $285 thousand , and the weighted-average period over which these grants are expected to vest is approximately 2.3 years .  The Company records equity instruments issued to non-employees as expense at their fair value over the related service period as determined in accordance with the authoritative guidance and periodically revalues the equity instruments as they vest.  Stock based compensation expense related to non-employee consultants recorded as operating expenses by the Company for TNK, LA Cell, CBC, Scintilla and Biologics was $44 thousand for each of the three months ended June 30, 2017 and 2016 and was $92 thousand for each of the six months ended June 30, 2017 and 2016, respectively.
The weighted-average assumptions used in the Black-Scholes option and warrant pricing model used by TNK, LA Cell, CBC, Scintilla and Biologics to determine the fair value of stock option grants for directors and non-employee consultants for the six months ended June 30, 2017 were as follows: expected dividend yield – 0% , risk-free interest rate – 2.42% to 2.48% , expected volatility – 65% to 77% , and expected term of 4.0 to 6.1 years .
2014 Stock Option Plan
In May 2014, the Company’s subsidiary, Ark Animal Health, Inc. (“Ark”), adopted the Ark 2014 Stock Option Plan and reserved and awarded 600,000 options to certain directors and consultants under such plan. Stock options granted under such plan typically vest a portion immediately upon grant and the remaining options over one year from the grant date and have a contractual term of ten years . As of June 30, 2017 , 322,000 options were outstanding.
The total director and consultant stock-based compensation recorded as operating expenses by the Company for Ark for each of the three months ended June 30, 2017 and 2016 was $0 and was $0 for each of the six months ended June 30, 2017 and 2016.  No unrecognized stock-based compensation expense related to unvested stock option grants existed as of June 30, 2017 .
14. Derivative Liability
On October 13, 2015, the Company wrote a call option to Cambridge, on up to 2.0 million shares of NantKwest common stock held by the Company (the “Option Agreement”).  As of December 31, 2015, the Company held approximately 5.6 million shares of common stock of NantKwest, par value $.0001 per share, which was classified as available-for-sale and reported in its consolidated financial statements as marketable securities.  The Option Agreement gave Cambridge the right to

33



purchase up to 2.0 million shares at a price of $15.295 per share from time to time in the first quarter of 2016.  There was no contractual option premium associated with this Option Agreement.  The Option Agreement was a derivative as defined in ASC Topic 815 and was recognized at fair value every reporting period the Option Agreement was in effect, with changes in fair value recognized in current operations.
The call option expired unexercised on March 31, 2016 and the Company recorded a gain of $5.5 million upon the cancellation of the derivative liability.
As of June 30, 2017 and December 31, 2016 , no derivative liability was recorded on the Company’s condensed consolidated balance sheets.
15. Commitments and Contingencies
Litigation
In the normal course of business, the Company may be named as a defendant in one or more lawsuits. The Company is not a party to any outstanding material litigation and management is currently not aware of any legal proceedings that, individually or in the aggregate, are deemed to be material to the Company’s financial condition or results of operations.
Derivative Action Litigation
On April 25, 2016, Wildcat Liquid Alpha, LLC (“WLA”) filed a complaint in the Court of Chancery of the State of Delaware seeking an order compelling the Company to provide WLA with certain documents, books and records for inspection and copying pursuant to an April 11, 2016 demand made by WLA (the “Inspection Demand Action”).  
On May 13, 2016, WLA filed a derivative action in the Court of Chancery of the State of Delaware (the “WLA Action” and, together with the Inspection Demand Action, the “Actions”) against each of the members of the Company’s board of directors at the time, Henry Ji, William S. Marth, Kim D. Janda, Jaisim Shah, David H. Deming, and Douglas Ebersole (the “Prior Board”) and against the Company as nominal defendant.  After the members of the Prior Board and the Company moved to dismiss, on August 12, 2016, WLA filed an amended complaint containing both direct and derivative claims against each of the members of the Prior Board and against the Company as nominal defendant, alleging, among other things: (1) breach of fiduciary duty with respect to the formation of, and certain options and warrants issued by, certain of the Company’s subsidiaries to Dr. Ji and members of the Prior Board (the “Subsidiary Options Claim”); (2) breach of fiduciary duty with respect to the Company’s prior announcement that it had entered into a voting agreement with Yuhan Corporation (“Yuhan”) in connection with a transaction through which it purchased $10 million of shares of the Company’s common stock and warrants (the “Yuhan Agreement Claim”); (3) waste of corporate assets regarding the foregoing; (4) unjust enrichment regarding the foregoing; and (5) violation of 8 Del. C. § 160 based on the Yuhan voting agreement.  
On March 17, 2017, the Company, the members of the Prior Board and WLA entered into a confidential settlement agreement and release (the “Settlement Agreement”) pursuant to which, among other things, each party agreed to forever release and not to sue the other party with respect to the claims asserted in the Actions and WLA agreed to take all actions to seek to dismiss the Actions without prejudice within ten business days following the execution of the Settlement Agreement. As part of the Settlement Agreement, the Company also agreed (1) to terminate all options and warrants currently outstanding in Company subsidiaries that have been granted to Dr. Ji and any other directors of the Company no later than 60 days after the Company’s next annual meeting of stockholders, (2) to grant WLA the right to designate a representative to attend all meetings of the Company’s board of directors in a nonvoting observer capacity, (3) to act in good faith to attempt to add two additional independent directors to the Company’s board of directors, and (4) to pay $400,000 as reimbursement for WLA’s out of pocket fees and expenses.  In addition, WLA agreed to comply with a two-year standstill period, during which WLA is prohibited from engaging in certain actions relating to controlling or influencing the management of the Company.  There was no impact from the termination of the options and warrants for the three or six months ended June 30, 2017 as a result of the Settlement Agreement.
On May 31, 2017, the Court of Chancery of the State of Delaware entered an order providing for dismissal of the Actions without prejudice pursuant to the terms of the Settlement Agreement, to be effective upon the Company submitting to the Court of Chancery of the State of Delaware a notice of the filing of a Current Report on Form 8-K with the Securities and Exchange Commission, which was filed on June 1, 2017.
On September 8, 2016, Yvonne Williams filed an action both derivatively and on behalf of a purported class of stockholders in the Court of Chancery of the State of Delaware against each of the members of the Prior Board; George Ng, the Company’s Executive Vice President, Chief Administrative Officer, and Chief Legal Officer; Jeffrey Su, the Company’s Executive Vice President & Chief Operating Officer; and the Company as nominal defendant, alleging: (1) breach of fiduciary

34



duty with respect to the Subsidiary Options Claim; and (2) breach of fiduciary duty with respect to the Yuhan Agreement Claim (the “Williams Action”). The Company is unable to determine whether any loss will occur with respect to the Williams Action or to estimate the range of such potential loss; therefore, no amount of loss has been accrued by the Company as of the date of filing of this Quarterly Report on Form 10-Q. Furthermore, there is no guarantee that the Company will prevail in this suit or receive any relief if it does prevail.
Immunomedics Litigation
On June 26, 2015, Immunomedics, Inc. (“Immunomedics”) filed a complaint in the United States District Court for the District of New Jersey (the “Immunomedics Action”) against the Board of Directors of Roger Williams Medical Center, Dr. Richard P. Junghans, Dr. Steven C. Katz, the Office of the Board of Advisors of Tufts University School of Medicine, and one or more individuals or entities to be identified later.  This complaint (the "Initial Complaint") alleged, among other things: (1) breach of contract; (2) breach of covenant of good faith and fair dealing; (3) tortious interference with prospective economic gain; (4) tortious interference with contracts; (5) misappropriation; (6) conversion; (7) bailment; (8) negligence; (9) vicarious liability; and (10) patent infringement.  Overall, the allegations in the Initial Complaint were generally directed to an alleged material transfer agreement dated December 2008 and Immunomedics’ alleged request for the return of certain alleged research material, as well as the alleged improper use and conversion of such research materials outside the scope of the material transfer agreement.  
On October 22, 2015, Immunomedics filed an amended complaint (the “First Amended Complaint”), which, among other things, no longer named the Board of Directors of Roger Williams Medical Center and The Office of the Board of Advisors of Tufts University School of Medicine as defendants. Roger Williams Medical Center and Tufts Medical Center were added as new defendants.  On January 14, 2016, Immunomedics filed a second amended complaint (the "Second Amended Complaint"), which, among other things, no longer named Tufts Medical Center as a defendant.  In addition, the Second Amended Complaint contained allegations directed to two additional alleged material transfer agreements dated September 1993 and May 2010, respectively, and also added an allegation of unjust enrichment.  The Second Amended Complaint also no longer asserted claims for (1)breach of covenant of good faith and fair dealing; (2)misappropriation; (3)bailment; (4) negligence; and (5) vicarious liability.  
On October 12, 2016, Immunomedics filed a third amended complaint (the “Third Amended Complaint”), which added the Company, TNK, BDL and CARgenix as defendants.  TNK is a subsidiary of the Company and purchased BDL and CARgenix in August 2015.  The Third Amended Complaint includes, among other things, allegations against the Company, TNK, BDL and CARgenix regarding (1) conversion; (2)tortious interference; and (3) unjust enrichment. On December 2, 2016, the Company, TNK, BDL, and CARgenix filed a motion to dismiss Immunomedics’s complaint against them for lack of personal jurisdiction.  On January 25, 2017, the District of New Jersey granted this motion, and the Company, TNK, BDL and CARgenix were dismissed as defendants from the case.  The Immunomedics Action remains pending in the District of New Jersey against defendants Roger Williams Medical Center, Dr. Junghans, and Dr. Katz.  A trial date has not yet been set.  The Company believes that the Immunomedics Action is without merit, and will vigorously defend itself against this and any further actions. However, should Immunomedics prevail against the Company, Roger Williams Medical Center or other defendants, certain patent rights optioned, owned and/or licensed by the Company could be at risk of invalidity or enforceability, or the litigation could otherwise adversely impact the Company’s ownership or other rights in certain intellectual property.  At this point in time, the Company is unable to determine whether any loss will occur with respect to the Immunomedics Action or to estimate the range of such potential loss; therefore, no amount of loss has been accrued by the Company as of the date of filing of this Quarterly Report on Form 10-Q.
Operating Leases
The Company currently leases in San Diego, California approximately 43,000 square feet of corporate office and laboratory space, approximately 6,350 square feet of laboratory and office space at a second location and approximately 1,405 square feet of office space at a third location.  The Company also previously leased approximately 1,800 square feet of office space in Cary, North Carolina, under a lease which expired in March 2016 and was not renewed.  The Company’s lease agreements in San Diego, as amended, for its corporate office and laboratory space, its second laboratory and office space and its third office space, expire in December 2026 , November 2025 and September 2020 , respectively.  The Company also leases 25,381 square feet of office and laboratory space in Suzhou, China, which lease expires in June 2018 .
Additionally, the Company entered into a new lease in San Diego, California for approximately 76,700 square feet of additional corporate office and laboratory space as well as approximately 36,400 square feet for offices, facilities for cGMP fill and finish and storage space. The lease began in February of 2017 and expires in November 2023 .

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16. Income Taxes
The Company maintains deferred tax assets that reflect the net tax effects of temporary differences between the carrying amounts of assets and liabilities for financial reporting purposes and the amounts used for income tax purposes. These deferred tax assets include net operating loss carryforwards, research credits and temporary differences. In assessing the Company's ability to realize deferred tax assets, management considers, on a periodic basis, whether it is more likely than not that some portion or all of the deferred tax assets will not be realized. As such, management has determined that it is appropriate to maintain a valuation allowance against the Company's U.S. federal and state deferred tax assets, with the exception of an amount equal to its deferred tax liabilities, which can be expected to reverse over a definite life and an amount equal to its alternative minimum tax credits and state research and development tax credits for which there is no expiration and the deferred tax assets related to its Scilex subsidiary.
The Company’s income tax benefit of  $3.1 million  and  $0  reflect effective tax rates of  7.5%  and 0% for the six months ended June 30, 2017 and 2016 , respectively.
The difference between the expected statutory federal tax benefit of  35%  and the  7.5%  effective tax benefit for the six months ended June 30, 2017 , was primarily attributable to the valuation allowance against most of the Company’s deferred tax assets. For the six months ended June 30, 2017 , when compared to the same period in 2016 , the increase in the tax benefit and increase in effective income tax rate was primarily attributable to the tax benefit recorded related to the Company’s Scilex investment.
The Company is subject to taxation in the U.S. and various state jurisdictions. The Company's tax years for 2007 and later are subject to examination by the U.S. and state tax authorities due to the existence of the NOL carryforwards.
As of the June 30, 2017 , the Company had approximately $2.8 million of unrecognized tax benefits that, if recognized, would impact the effective income tax rate for continuing operations, subject to possible offset by an increase in the deferred tax asset valuation allowance. As of June 30, 2016 , the Company had approximately $1.8 million of   unrecognized tax benefits that, if recognized, would impact the effective income tax rate for continuing operations, subject to possible offset by an increase in the deferred tax asset valuation allowance.
The Company recognizes interest and penalties related to unrecognized tax benefits in its provision for income taxes. For the six months ended June 30, 2017 and 2016 , no expense was recorded related to interest and penalties. The Company believes that no significant amount of the liabilities for uncertain tax positions will expire within twelve months of June 30, 2017 .
17. Related Party Agreements
During the year ended December 31, 2015, the Company entered into a joint venture called Immunotherapy NANTibody, LLC, with NantCell, a wholly-owned subsidiary of NantWorks.  In July 2015, the Company contributed its portion of the initial joint funding of $40.0 million to the NANTibody joint venture.  The Company and NantCell have also entered into a license agreement pursuant to which the Company received a $10.0 million upfront license payment and $100.0 million of vested NantCell common stock.  
During the year ended December 31, 2015, the Company entered into a joint venture called NantCancerStemCell, LLC, with NantBioScience, a wholly-owned subsidiary of NantWorks.  In connection with negotiated changes to the structure of NantStem the Company issued a call option on shares of NantKwest that it owned to Cambridge, a related party to the Company and to NantBioScience.  In April 2015, the Company purchased 1.0 million shares of NantBioScience common stock for $10.0 million .  
In March 2016, the Company and Yuhan entered into an agreement to form a joint venture company called ImmuneOncia Therapeutics, LLC, to develop and commercialize a number of immune checkpoint antibodies against undisclosed targets for both hematological malignancies and solid tumors.  As of June 30, 2017 , the carrying value of the Company’s investment in ImmuneOncia Therapeutics, LLC was approximately $8.7 million . During the three months ended June 30, 2016, Yuhan purchased $10.0 million of Common Stock and warrants.
In June 2016, the Company and TNK entered into a joint venture agreement with 3SBio to develop and commercialize proprietary immunotherapies, including those developed from, including or using TNK’s CAR-T technology targeting CEA positive cancers.  In June 2016, 3SBio purchased $10.0 million of Common Stock and warrants.
On November 8, 2016, the Company entered into a Stock Purchase Agreement with Scilex and a majority of the stockholders of Scilex (the “Scilex Stockholders”) pursuant to which the Company acquired from the Scilex Stockholders

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approximately 72% of the outstanding capital stock of Scilex. Dr. Henry Ji, the Company’s President and Chief Executive Officer and a member of the Company’s Board of Directors, and George K. Ng, the Company’s Vice President, Chief Administrative Officer and Chief Legal Officer, were stockholders of Scilex prior to the acquisition transaction.

Item 2.    Management’s Discussion and Analysis of Financial Condition and Results of Operations.
This Quarterly Report on Form 10-Q contains “forward-looking statements” about our expectations, beliefs or intentions regarding our potential product offerings, business, financial condition, results of operations, strategies or prospects. You can identify forward-looking statements by the fact that these statements do not relate strictly to historical or current matters. Rather, forward-looking statements relate to anticipated or expected events, activities, trends or results as of the date they are made and are often identified by the use of words such as “assumes,” “plans,” “anticipate,” “believe,” “continue,” “could,” “estimate,” “expect,” “intend,” “may,” “might,” or “will,” and similar expressions or variations. Because forward-looking statements relate to matters that have not yet occurred, these statements are inherently subject to risks and uncertainties that could cause our actual results to differ materially from any future results expressed or implied by the forward-looking statements. Many factors could cause our actual activities or results to differ materially from the activities and results anticipated in forward-looking statements. These factors include those described under the caption “Risk Factors” included elsewhere in this Quarterly Report on Form 10-Q and in our other filings with the Securities and Exchange Commission (the “SEC”). Furthermore, such forward-looking statements speak only as of the date of this report. We undertake no obligation to update any forward-looking statements to reflect events or circumstances occurring after the date of such statements.
Overview
We are a clinical stage biotechnology company focused on delivering clinically meaningful therapies to patients and their families, globally. Our primary focus is to transform cancer into a treatable or chronically manageable disease. We also have programs assessing the use of our technologies and products in auto-immune, inflammatory, neurodegenerative and infectious diseases and pain indications with high unmet medical needs.
At our core, we are an antibody-centric company and leverage our proprietary G-MAB™ library and targeted delivery modalities to generate the next generation of cancer therapeutics. Our validated fully human antibodies include PD-1, PD-L1, CD38, CD123, CD47, c-MET, VEGFR2, CCR2, OX40, TIGIT and CD137 among others. Our vision is to leverage these antibodies in conjunction with proprietary targeted delivery modalities to generate the next generation of cancer therapeutics. These modalities include proprietary antibody drug conjugates (“ADCs”), bispecific approaches, as well as TCR-like antibodies. With LA Cell, Inc. (“LA Cell”), our joint venture with City of Hope, our objective is to become the global leader in the development of antibodies against intracellular targets such as STAT3, mutant KRAS, MYC, p53 and TAU. Additionally, we have acquired and are assessing the regulatory and strategic path forward for our portfolio of late stage biosimilar/biobetter antibodies based on Erbitux ® , Remicade ® , Xolair ® , and Simulect ® as these may represent nearer term commercial opportunities.
Although we intend to retain ownership and control of product candidates by advancing their development, we regularly also consider, (i) partnerships with pharmaceutical or biopharmaceutical companies and (ii) license or sale of certain products in each case, in order to balance the risks and costs associated with drug discovery, development and commercialization with efforts to maximize our stockholders’ returns. Our partnering objectives include generating revenue through license fees, milestone-related development fees and royalties as well as profit shares or joint ventures to generate potential returns from our product candidates and technologies.
Recent Developments
Binding Term Sheet Regarding Acquisition of Semnur Pharmaceuticals, Inc.
On August 15, 2016, the Company’s subsidiary, Scintilla Pharmaceuticals, Inc. (“Scintilla”) and Semnur Pharmaceuticals, Inc. (“Semnur”) entered into a binding term sheet (the “Semnur Binding Term Sheet”) setting forth the terms and conditions by which Scintilla will, through a subsidiary, purchase all of the issued and outstanding equity of Semnur (the “Semnur Acquisition”). The Semnur Binding Term Sheet provides that, contingent upon the execution of a definitive agreement between the parties (the “Definitive Agreement”) and subject to certain conditions, Scintilla will, at the closing of the Semnur Acquisition (the “Semnur Closing”), make an initial payment of $60.0 million (the “Initial Consideration”) to the equityholders of Semnur in exchange for all of the issued and outstanding equity of Semnur. The Initial Consideration will consist of $40.0 million in cash and $20.0 million in shares of our common stock (the “Semnur Stock Consideration”). The Semnur Binding

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Term Sheet also provides that the number of shares of our common stock comprising the Semnur Stock Consideration will be calculated based on the volume weighted average closing price of our common stock for the 30 consecutive trading days ending on the date that is three days prior to the execution of the Definitive Agreement. $6.0 million of the Semnur Stock Consideration will be placed into escrow, a portion of which will be held for a period of up to six or 12 months to secure certain obligations of Semnur and its equityholders in connection with the Semnur Acquisition. At the Semnur Closing, we will enter into a registration rights agreement with certain of Semnur’s equityholders, pursuant to which we will agree to seek the registration for resale of the shares of our common stock comprising the Semnur Stock Consideration.
In addition to the Initial Consideration, Scintilla may pay additional consideration of up to $140.0 million to Semnur’s equityholders upon Scintilla’s completion of certain clinical studies and trials, receipt of certain regulatory approvals and the achievement of certain sales targets following the Semnur Closing.
Under the Semnur Binding Term Sheet, either party may terminate the Semnur Binding Term Sheet.
As of June 30, 2017, the Semnur Acquisition had not closed. The final terms of the Semnur Acquisition are subject to the negotiation and finalization of the Definitive Agreement and any other agreements relating to the Semnur Acquisition, and the material terms of the Semnur Acquisition are expected to differ from those set forth in the Semnur Binding Term Sheet. In addition, the Semnur Closing will be subject to various customary and other closing conditions.
A member of our board of directors is Semnur’s Chief Executive Officer and a member of Semnur’s Board of Directors and currently owns approximately 5.5% of Semnur’s total outstanding capital stock. Joseph Gunnar & Co., LLC provided an opinion to our board of directors opining that the consideration to be paid by Scintilla in the Semnur Acquisition is fair, from a financial point of view, to our stockholders.
Public Offering of Common Stock
On April 13, 2017, we entered into an underwriting agreement (the “Underwriting Agreement”) with Cantor Fitzgerald & Co., as representative of the several underwriters named therein (the “Underwriters”), relating to an underwritten public offering (the “Offering”) of 23,625,084 shares of our common stock. The public offering price was $2.00 per share of our common stock and the Underwriters agreed to purchase the shares of our common stock pursuant to the Underwriting Agreement at a price of $1.8571 per share. Under the terms of the Underwriting Agreement, we also granted to the Underwriters an option, exercisable in whole or in part at any time for a period of 30 days from the date of the closing of the Offering, to purchase up to an additional 3,543,763 shares of our common stock at the public offering price. 
On April 19, 2017, the Offering was completed and resulted in net proceeds of approximately $43.5 million (excluding any sale of shares of common stock pursuant to the option granted to the Underwriters), after deducting underwriting discounts and commissions and estimated Offering expenses payable by us.
Acquisition of Virttu Biologics Limited
On April 27, 2017, we entered into a Share Purchase Agreement (the “Virttu Purchase Agreement”) with TNK Therapeutics, Inc., our majority-owned subsidiary (“TNK”), Virttu Biologics Limited (“Virttu”), the shareholders of Virttu (the “Virttu Shareholders”) and Dayspring Ventures Limited, as the representative of the Virttu Shareholders, pursuant to which, among other things, TNK acquired from the Virttu Shareholders 100% of the outstanding ordinary shares of Virttu (the “Virttu Acquisition”).
Virttu focuses on the development of oncolytic viruses that infect and selectively multiply in and destroy tumor cells without damaging healthy tissue. Its lead oncolytic virus candidate, Seprehvir, infects and replicates in cancer cells selectively, leaving normal cells unharmed.
Under the Virttu Purchase Agreement, the total amount of the consideration payable to the Virttu Shareholders in the Virttu Acquisition is equal to $25 million, less Virttu’s net debt (the “Virttu Base Consideration”). An additional $10 million contingent consideration is payable upon the achievement of certain regulatory milestones (as described below) (the “Regulatory Approval Consideration”).
At the closing of the Virttu Acquisition (the “Closing”), we issued to the Virttu Shareholders consideration valued at approximately $2.2 million, which consisted primarily of an aggregate of 797,081 shares (the “Virttu Closing Shares”) and approximately $557,000 in cash (the “Cash Consideration”). The issuance of the Closing Shares and the payment of the Cash Consideration satisfied TNK’s obligation to pay 20% of the Virttu Base Consideration at the Closing. Under the terms of the Virttu Purchase Agreement, we agreed to provide additional consideration to the Virttu Shareholders, as follows:

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(1) Upon a financing resulting in gross proceeds (individually or in the aggregate) to TNK of at least $50.0 million (a “Qualified Financing”), TNK will issue to the Virttu Shareholders an aggregate number of shares of its capital stock (“TNK Capital Stock”) as is equal to the quotient obtained by dividing 80% of the Virttu Base Consideration by the lowest per share price paid by investors in the Qualified Financing (the “TNK Financing Consideration”); provided, however, that 20% of the TNK Financing Consideration shall be held in escrow until April 27, 2018 (the “Financing Due Date”), to be used to, among other things, satisfy the indemnification obligations of the Virttu Shareholders. In the event that a Qualified Financing does not occur, then on the Financing Due Date, we will issue to the Virttu Shareholders an aggregate number of shares of our common stock as is equal to the quotient obtained by dividing 80% of the Virttu Base Consideration, by $5.55 (as adjusted, as appropriate, to reflect any stock splits or similar events affecting our common stock after the Closing).
(2) Within 45 business days after Virttu becomes aware that certain governmental bodies in the United States, the European Union, the United Kingdom or Japan have approved for commercialization, on or before October 26, 2024, Seprehvir (or any enhancement, combination or derivative thereof) as a monotherapy or in combination with one or more other active components (each of the first two such approvals by a governmental body being a “Regulatory Approval”), TNK shall pay half of the Regulatory Approval Consideration to the Virttu Shareholders, in a combination of (a) up to $5.0 million in cash (the “Regulatory Approval Cash”) and/or (b) (i) such number of shares of our common stock as is equal to the quotient obtained by dividing $5.0 million less the Regulatory Approval Cash (the “Regulatory Approval Share Value”) by the 30 Day VWAP (as defined below) of one share of our common stock; (ii) if TNK has completed its first public offering of TNK Capital Stock, the number of shares of TNK Capital Stock as is equal to the quotient obtained by dividing the Regulatory Approval Share Value by the 30 Day VWAP of one share of TNK Capital Stock; or (iii) such number of shares of common stock of a publicly traded company as is equal to the quotient obtained by dividing the Regulatory Approval Share Value by the volume weighted average price of the relevant security, as reported on the Nasdaq Capital Market (or other principal stock exchange or securities market on which the shares are then listed or quoted) for the thirty trading days immediately following the receipt of Regulatory Approval (the “30 Day VWAP”), with the composition of the Regulatory Approval Consideration to be at TNK’s option. In order for a second regulatory approval to qualify as a Regulatory Approval under the Purchase Agreement, the second approval must be granted by a different governmental body in a different jurisdiction than that which granted the first Regulatory Approval.
Celularity Transaction
On November 1, 2016, we loaned $5.0 million to Celularity, Inc., a research and development company (“Celularity”), pursuant to a promissory note issued by us to Celularity, as amended (as so amended, the “Celularity Note”), in connection with the entry into a nonbinding term sheet by us, TNK and Celularity.  Pursuant to the terms of the Celularity Note, the loan will be due and payable in full on the earlier of November 1, 2017 and the occurrence of an event of default under the Celularity Note (the “Maturity Date”). In the event that Celularity meets certain minimum financing conditions prior to the Maturity Date, all outstanding amounts under the Celularity Note shall be forgiven and converted to equity. On May 31, 2017, we loaned an additional $2.0 million to Celularity pursuant to the terms of the Celularity Note. On June 14, 2017, we loaned an additional $1.0 million to Celularity. Additionally, on July 7, 2017, we loaned an additional $2.0 million to Celularity.
On June 12, 2017, we entered into a Contribution Agreement (the “Contribution Agreement”) with TNK and Celularity, pursuant to which, among other things, we and TNK agreed to contribute certain intellectual property rights related to our proprietary chimeric antigen receptor (“CAR”) constructs and related CARs to Celularity in exchange for shares of Celularity’s Series A Preferred Stock equal to 25% of Celularity’s outstanding shares of capital stock, calculated on a fully-diluted basis. The contribution will be made pursuant to a License and Transfer Agreement to be entered into by and among us, TNK and Celularity.
As of June 30, 2017, the transactions contemplated by the Contribution Agreement had not closed.
Critical Accounting Policies and Estimates
Management’s discussion and analysis of our financial condition and results of operations are based upon our condensed consolidated financial statements which are prepared in accordance with GAAP. The preparation of these financial statements requires us to make estimates and judgments that affect the reported amounts of assets and liabilities, related disclosure of contingent assets and liabilities at the date of the financial statements, and the reported amounts of revenues and expenses during the reporting period. We continually evaluate our estimates and judgments, the most critical of which are those related to income taxes and stock-based compensation. We base our estimates and judgments on historical experience and other factors that we believe to be reasonable under the circumstances. Materially different results can occur as circumstances change and additional information becomes known.

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During the quarter ended June 30, 2017, there were no significant changes to the items that we disclosed as our critical accounting policies and estimates in Note 3 to our consolidated financial statements for the year ended December 31, 2016 contained in our Annual Report on Form 10-K for the year ended December 31, 2016, as amended, as filed with the SEC.
Results of Operations
The following describes certain line items set forth in our condensed consolidated statements of operations.
Comparison of the Three Months Ended June 30, 2017 and 2016
Revenues . Revenues were $4.7 million for the three months ended June 30, 2017 , as compared to $902 thousand for the three months ended June 30, 2016 . The net increase of $3.8 million is primarily due to an increase in our sales and services of $2.4 million related to contract manufacturing services as well as increases in royalty and license revenues of $1.6 million resulting primarily from our collaboration arrangements.
In June 2014, the National Institute of Allergy and Infectious Diseases (“NIAID”), a division of the National Institutes of Health, or NIH awarded us a Phase II STTR grant to support the advanced preclinical development of human bispecific antibody therapeutics to prevent and treat Staphylococcus aureus ( S. aureus or Staph) infections, including methicillin-resistant S. aureus (MRSA), or the Staph Grant III award. The project period for this Phase II grant covers a two-year period which commenced in June 2014, which was subsequently extended by one year, with total funds available of approximately $1 million per year. During the three months ended June 30, 2017 and 2016 , we recorded $95 thousand and $218 thousand of revenue, respectively, associated with the Staph Grant III award.
We expect that any revenue we generate will fluctuate from quarter to quarter as a result of the unpredictability of the demand for products and services offered as well as the timing and amount of grant awards, research and development reimbursements and other payments received under any strategic collaborations, if any.
Cost of revenues . Cost of revenues for the three months ended June 30, 2017 and 2016 were $816 thousand and $295 thousand , respectively, and relate to the sale of customized reagents and providing contract development services. The costs generally include employee-related expenses including salary and benefits, direct materials and overhead costs including rent, depreciation, utilities, facility maintenance and insurance. The increase of $521 thousand is primarily attributable to increased indirect costs associated with the higher sales and service revenues for next generation homogenous antibody drug conjugate development.
Research and Development Expenses . Research and development expenses for the three months ended June 30, 2017 and 2016 were $11.2 million and $10.7 million , respectively. Research and development expenses include the costs to advance our CAR-T programs for solid tumors, our RTX program towards entering into future clinical trials, our biosimilar/biobetter antibodies development, costs to identify, isolate and advance human antibody drug candidates derived from our libraries as well as advancing our ADC preclinical drug candidates, preclinical testing expenses and the expenses associated with fulfilling our development obligations related to the NIH grant awards, collectively the NIH Grants. Such expenses consist primarily of salaries and personnel related expenses, stock-based compensation expense, clinical development expenses, preclinical testing, lab supplies, consulting costs, depreciation and other expenses. The increase of $0.4 million is primarily attributable to increased payroll expense for research and development. We expect research and development expenses to increase in absolute dollars as we: (i) advance our CAR-T programs, (ii) advance RTX into clinical trials and pursue other potential indications, the cost of acquiring, developing and manufacturing clinical trial materials, and other regulatory operating activities, (iii) advance our biosimilar/biobetter antibodies clinical development program, (iv) incur incremental expenses associated with our efforts to further advance a number of potential product candidates into preclinical development activities, (v) continue to identify and advance a number of fully human therapeutic antibody and ADC preclinical product candidates, (vi) incur higher salary, lab supply and infrastructure costs incurred in connection with supporting all of our programs, and (vii) invest in our JVs or other third party agreements.
Acquired In-process Research and Development Expenses . Acquired in-process research and development expenses for the three months ended June 30, 2017 and 2016 were $0 and $32.0 million, respectively. The decrease is due to cost associated with the purchase price of the license rights from Mabtech Limited and the purchase price of the license rights from the City of Hope in the prior year.
General and Administrative Expenses . General and administrative expenses for the three months ended June 30, 2017 and 2016 were $9.1 million and $4.2 million , respectively. General and administrative expenses consist primarily of salaries and personnel related expenses for executive, finance and administrative personnel, stock-based compensation expense, professional fees, infrastructure expenses, legal and accounting expenses and other general corporate expenses. The increase of

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$4.9 million is primarily attributable to higher salaries and related compensation expenses resulting from new hires of approximately $3.1 million and higher legal costs associated with litigation matters of approximately $1.8 million.
We expect general and administrative expenses to increase in absolute dollars as we: (i) incur incremental expenses associated with expanded operations and development efforts, (ii) compliance with our public reporting obligations, (iii) increased infrastructure costs, and (iv) invest in our JVs or other third party agreements.
Intangible Amortization . Intangible amortization for the three months ended June 30, 2017 and 2016 was $665 thousand and $111 thousand , respectively. The increase in the three months ended June 30, 2017 as compared to the same period in 2016 is due to the intangible assets acquired as part of the Scilex acquisition in the fourth quarter of the prior year.
Income (loss) on equity investments .  Income (Loss) on equity investments for the three months ended June 30, 2017 and 2016 was $(1,102) thousand and $470 thousand , respectively.  
Interest Expense . Interest expense for the three months ended June 30, 2017 and 2016 was $1.2 million and $0.3 million , respectively. The increase in interest expense resulted primarily from higher average borrowings under the amended loan and security agreement.
Interest Income . Interest income for the three months ended June 30, 2017 and 2016 was $232 thousand and $45 thousand , respectively. We expect that continued low interest rates will significantly limit our interest income in the near term.
Income tax benefit . Income tax benefit for the three months ended June 30, 2017 and 2016 was $1,398 thousand and $0 , respectively. The increase in income tax benefit resulted mainly from the amortization and decrease of deferred tax liabilities.
Net Loss . Net loss for the three months ended June 30, 2017 and 2016 was $14.7 million and $44.5 million , respectively.  
Comparison of the Six Months Ended June 30, 2017 and 2016
Revenues . Revenues were $9.5 million for the six months ended June 30, 2017 , as compared to $1.9 million for the six months ended June 30, 2016 . The net increase of $7.6 million is primarily due to an increase in our sales and services of $4.8 million related to contract manufacturing services of $3.4 million as well as our royalty and license revenues resulting primarily from our collaboration arrangements.
In June 2014, the National Institute of Allergy and Infectious Diseases (“NIAID”), a division of the National Institutes of Health, or NIH awarded us a Phase II STTR grant to support the advanced preclinical development of human bispecific antibody therapeutics to prevent and treat Staphylococcus aureus ( S. aureus or Staph) infections, including methicillin-resistant S. aureus (MRSA), or the Staph Grant III award. The project period for this Phase II grant covers a two-year period which commenced in June 2014, which was subsequently extended by one year, with total funds available of approximately $1 million per year. During the six months ended June 30, 2017 and 2016 , we recorded $195 thousand and $457 thousand of revenue, respectively, associated with the Staph Grant III award.
We expect that any revenue we generate will fluctuate from quarter to quarter as a result of the unpredictability of the demand for products and services offered as well as the timing and amount of grant awards, research and development reimbursements and other payments received under any strategic collaborations, if any.
Cost of revenues . Cost of revenues for the six months ended June 30, 2017 and 2016 were $1.9 million and $0.7 million , respectively, and relate to the sale of customized reagents and providing contract development services. The costs generally include employee-related expenses including salary and benefits, direct materials and overhead costs including rent, depreciation, utilities, facility maintenance and insurance. The increase of $1.2 million is primarily attributable to increased indirect costs associated with the higher sales and service revenues for next generation homogenous antibody drug conjugate development.
Research and Development Expenses . Research and development expenses for the six months ended June 30, 2017 and 2016 were $26.1 million and $18.4 million , respectively. Research and development expenses include the costs to advance our CAR-T programs for solid tumors, our RTX program towards entering into future clinical trials, our biosimilar/biobetter antibodies development, costs to identify, isolate and advance human antibody drug candidates derived from our libraries as well as advancing our ADC preclinical drug candidates, preclinical testing expenses and the expenses associated with fulfilling our development obligations related to the NIH grant awards, collectively the NIH Grants. Such expenses consist primarily of salaries and personnel related expenses, stock-based compensation expense, clinical development expenses, preclinical testing, lab supplies, consulting costs, depreciation and other expenses. The increase of $7.7 million is primarily attributable to increased payroll expense for research and development. We expect research and development expenses to increase in absolute dollars as we: (i) advance our CAR-T programs, (ii) advance RTX into clinical trials and pursue other potential indications, the

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cost of acquiring, developing and manufacturing clinical trial materials, and other regulatory operating activities, (iii) advance our biosimilar/biobetter antibodies clinical development program, (iv) incur incremental expenses associated with our efforts to further advance a number of potential product candidates into preclinical development activities, (v) continue to identify and advance a number of fully human therapeutic antibody and ADC preclinical product candidates, (vi) incur higher salary, lab supply and infrastructure costs incurred in connection with supporting all of our programs, and (vii) invest in our JVs or other third party agreements.
Acquired In-process Research and Development Expenses . Acquired in-process research and development expenses for the six months ended June 30, 2017 and 2016 were $0.2 million and $45.0 million , respectively. The decrease is due to cost associated with the purchase price of the license rights from Mabtech Limited and the purchase price of the license rights from the City of Hope in the prior year.
General and Administrative Expenses . General and administrative expenses for the six months ended June 30, 2017 and 2016 were $21.0 million and $8.7 million , respectively. General and administrative expenses consist primarily of salaries and personnel related expenses for executive, finance and administrative personnel, stock-based compensation expense, professional fees, infrastructure expenses, legal and accounting expenses and other general corporate expenses. The increase of $12.3 million is primarily attributable to higher salaries and related compensation expenses resulting from new hires of approximately $6.9 million and higher legal costs associated with litigation matters of approximately $4.6 million.
We expect general and administrative expenses to increase in absolute dollars as we: (i) incur incremental expenses associated with expanded operations and development efforts, (ii) compliance with our public reporting obligations, (iii) increased infrastructure costs, and (iv) invest in our JVs or other third party agreements.
Intangible Amortization . Intangible amortization for the six months ended June 30, 2017 and 2016 was $1.3 million and $0.2 million , respectively. The increase in the six months ended June 30, 2017 as compared to the same period in 2016 is due to the intangible assets acquired as part of the Scilex acquisition in the fourth quarter of the prior year.
Income (loss) on equity investments .  Income (loss) on equity investments for the six months ended June 30, 2017 and 2016 was $(2,050) thousand and $(29) thousand, respectively.  
Interest Expense . Interest expense for the six months ended June 30, 2017 and 2016 was $2.8 million and $0.6 million , respectively. The increase in interest expense resulted primarily from higher average borrowings under the amended loan and security agreement.
Interest Income . Interest income for the six months ended June 30, 2017 and 2016 was $457 thousand and $58 thousand , respectively. We expect that continued low interest rates will significantly limit our interest income in the near term.
Income tax benefit . Income tax benefit for the six months ended June 30, 2017 and 2016 was $3 million and $0 , respectively. The increase in income tax benefit resulted mainly from the amortization and decrease of deferred tax liabilities.
Net Loss . Net loss for the six months ended June 30, 2017 and 2016 was $38.5 million and $61.8 million , respectively.  
Liquidity and Capital Resources
As of June 30, 2017 , we had $53.7 million in cash and cash equivalents attributable in part to the net proceeds received under the loan and security agreement that we and certain of our domestic subsidiaries (collectively, the “Borrowers”) entered into with Hercules Capital, Inc. (“Hercules”) on November 23, 2016, as amended (as so amended, the “Loan Agreement”).  As of June 30, 2017 , we had $26.5 million of long term debt associated with the Loan Agreement. The Loan Agreement contains covenants requiring us (i) to achieve certain fundraising requirements by certain dates, and (ii) to maintain $20.0 million of U.S. unrestricted cash prior to achieving the corporate and fundraising milestones.  The Offering (as described below) satisfied the fundraising requirements and fundraising milestone. We are currently in compliance with these covenants, and have plans in place to maintain compliance with these covenants. To the extent we are unable to execute on these plans to maintain compliance with these covenants, or we are unable to amend the Loan Agreement to maintain such compliance then we would be in default under the Loan Agreement and the outstanding loan balance may be declared immediately due and payable.   If the outstanding loan balance was payable in the next 12 months and we are unable to secure additional sources of financing, we would not have enough cash to fund our operating and capital requirements for the next 12 months. We cannot be certain that additional funding will be available on acceptable terms, or at all. If we issue additional equity securities to raise funds, the ownership percentage of existing stockholders would be reduced. New investors may demand rights, preferences or privileges senior to those of existing holders of common stock. If we are unable to raise additional capital in sufficient amounts or on terms acceptable to us we may have to significantly delay, scale back or discontinue the development or commercialization of one or more of our product candidates. We may also seek collaborators for one or more of our current or future product

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candidates at an earlier stage than otherwise would be desirable or on terms that are less favorable than might otherwise be available. These factors raise substantial doubt about our ability to continue as a going concern. Our financial statements and related notes thereto included elsewhere in this Quarterly Report on Form 10-Q do not include any adjustments that might result from the outcome of this uncertainty.
Cash Flows from Operating Activities . Net cash used for operating activities was $41.7 million for the six months ended June 30, 2017 and is primarily attributable to our net loss of $38.5 million , partially offset by $2.6 million in non-cash activities relating to stock-based compensation.
We expect to continue to incur substantial and increasing losses and negative net cash flows from operating activities as we seek to expand and support our clinical and preclinical development and research activities and fund our joint ventures, collaborations and other third party agreements.
Cash Flows from Investing Activities . Net cash used for investing activities was $10.3 million for the six months ended June 30, 2017 as compared to $2.2 million for the six months ended June 30, 2016 . The net cash used related primarily to equipment acquired for research and development activities.
We expect to increase our investment in equipment as we seek to expand and progress our research and development capabilities.
Cash Flows from Financing Activities . Net cash provided by financing activities was $23.1 million for the six months ended June 30, 2017 as compared to net cash provided financing of $93.7 million for the six months ended June 30, 2016 , which was primarily due to the repayment associated with the amended loan and security agreement in the current year.
Future Liquidity Needs . We have principally financed our operations through underwritten public offerings and private equity financings with aggregate net proceeds of approximately $196.5 million, as we have not generated any product related revenue from our principal operations to date, and do not expect to generate significant revenue for several years, if ever. We will need to raise additional capital before we exhaust our current cash resources in order to continue to fund our research and development, including our plans for clinical and preclinical trials and new product development, as well as to fund operations generally. As and if necessary, we will seek to raise additional funds through various potential sources, such as equity and debt financings, or through corporate collaboration and license agreements. We can give no assurances that we will be able to secure such additional sources of funds to support our operations, or, if such funds are available to us, that such additional financing will be sufficient to meet our needs.
We anticipate that we will continue to incur net losses into the foreseeable future as we: (i) advance RTX and other product candidates into clinical trials and potentially pursue other development, (ii) continue to identify and advance a number of potential mAb and ADC product candidates into preclinical development activities, (iii) continue our development of, and seek regulatory approvals for, our product candidates, (iv) expand our corporate infrastructure, including the costs associated with being a NASDAQ listed public company, and (v) incur our share of joint venture and collaboration costs for our products and technologies.
We plan to continue to fund our operating losses and capital funding needs through public or private equity or debt financings, strategic collaborations, licensing arrangements, asset sales, government grants or other arrangements.
In November 2014, we filed a universal shelf registration statement on Form S-3 with the U.S. Securities and Exchange Commission (the “SEC”), which was declared effective by the SEC in December 2014. This Shelf Registration Statement provides us with the ability to offer up to $250 million of securities, including equity and other securities as described in the registration statement. Included in the November 2014 shelf registration is a sales agreement prospectus covering the offering, issuance and sale by us of up to a maximum aggregate offering price of $50.0 million of our common stock that may be issued and sold under a sales agreement with MLV & Co. LLC (the “ATM Facility”). During the twelve months ended December 31, 2016 and the six months ended June 30, 2017, we sold approximately $3.6 million and $2.5 million in shares of common stock under the ATM Facility, respectively.  We can offer up to $43.9 million of additional shares of common stock under the ATM Facility, subject to certain limitations. On April 19, 2017, we completed the Offering of $47.5 million shares of common stock pursuant to the shelf registration statement and received net proceeds of approximately $43.5 million.
Pursuant to this Shelf Registration Statement, we may offer additional securities from time to time and through one or more methods of distribution, subject to market conditions and our capital needs. Specific terms and prices will be determined at the time of each offering under a separate prospectus supplement, which will be filed with the SEC at the time of any offering.

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On April 3, 2016, we entered into a Securities Purchase Agreement (the “ABG Purchase Agreement”) with ABG SRNE Limited and Ally Bridge LB Healthcare Master Fund Limited (collectively, “Ally Bridge”), pursuant to which, among other things, we agreed to issue and sell to Ally Bridge and other purchasers that may be designated by Ally Bridge (collectively, the “ABG Purchasers”), in a private placement transaction (the “ABG Private Placement”), up to $50.0 million in shares of our common stock (“Common Stock”) and warrants to purchase shares of Common Stock. Upon the closing of the ABG Private Placement, we issued to the ABG Purchasers (1) an aggregate of 9,009,005 shares (the “ABG Shares”) of Common Stock,   and (2) warrants to purchase an aggregate of 2,702,700 shares of Common Stock (each, an “ABG Warrant”).   Each ABG Warrant had an exercise price of $8.50 per share, was immediately exercisable upon issuance, had a term of three years and was exercisable on a cash or cashless exercise basis. 
Under the terms of the ABG Purchase Agreement, we were obligated to prepare and file with the SEC, within 30 days of the closing date of the ABG Private Placement, a registration statement to register for resale the ABG Shares and the shares of Common Stock issuable upon exercise of each ABG Warrant (the “ABG Warrant Shares”), and may be required to effect certain registrations to register for resale the ABG Shares and the ABG Warrant Shares in connection with certain “piggy-back” registration rights granted to the ABG Purchasers.
On April 3, 2016, we also entered into a Securities Purchase Agreement (collectively, the “Additional Purchase Agreements”) with each of Beijing Shijilongxin Investment Co., Ltd. ( “Beijing Shijilongxin”), FREJOY Investment Management Co., Ltd. (“Frejoy”) and Yuhan, pursuant to which, among other things, we agreed to issue and sell, in separate private placement transactions: (1) to Beijing Shijilongxin, 8,108,108 shares of Common Stock, and a warrant to purchase 1,176,471 shares of Common Stock, for an aggregate purchase price of $45.0 million; (2) to Frejoy, 8,108,108 shares of Common Stock, and a warrant to purchase 1,176,471 shares of Common Stock, for an aggregate purchase price of $45.0 million; and (3) to Yuhan, 1,801,802 shares of Common Stock, and a warrant to purchase 235,294 shares of Common Stock, for an aggregate purchase price of $10.0 million. The warrants to be issued pursuant to each of the Additional Purchase Agreements (collectively, the “Additional Warrants” and, together with each ABG Warrant, the “Warrants”) had an exercise price of $8.50 per share, were immediately exercisable upon issuance, had a term of three years and were exercisable on a cash or cashless exercise basis.
Under the terms of the Additional Purchase Agreements, each of Beijing Shijilongxin, Frejoy and Yuhan had the right to demand, at any time beginning six months after the closing of the transactions contemplated by the applicable Additional Purchase Agreement, that we prepare and file with the SEC a registration statement to register for resale such investor’s shares of Common Stock purchased pursuant to the applicable Additional Purchase Agreement and the shares of Common Stock issuable upon exercise of such investor’s Additional Warrant. In addition, we may be required to effect certain registrations to register for resale such shares in connection with certain “piggy-back” registration rights granted to Beijing Shijilongxin, Frejoy and Yuhan.
On May 2, 2016, we closed our private placement of common stock and warrants with Yuhan for gross proceeds of $10.0 million.  Yuhan purchased 1,801,802 shares of common stock at $5.55 per share and a warrant to purchase 235,294 shares of common stock.  The warrant was exercisable for three years at an exercise price of $8.50 per share.
Between May 31, 2016 and June 7, 2016, we closed on the remainder of the $150.0 million financing. The ABG Purchasers led the financing and, together with Beijing Shijilongxin and Frejoy, collectively purchased 25,225,221 shares of common stock at $5.55 per share, and warrants to purchase 5,055,642 shares of common stock for total consideration of $140.0 million.
On November 23, 2016, we and the other Borrowers entered into the Loan Agreement with Hercules. The Loan Agreement provides for a term loan of up to $75.0 million, subject to funding in multiple tranches (the “Term Loan”). The proceeds of the Term Loan will be used for general corporate purposes and coincided with the repayment of the outstanding debt financing arrangement with Oxford Finance LLC and Silicon Valley Bank.
The first tranche of $50.0 million of the Term Loan was funded upon execution of the Loan Agreement on November 23, 2016. Under the terms of the Loan Agreement, as most recently amended in March 2017, the Borrowers may, but are not obligated to, request additional funds of up to $25.0 million which are available until June 30, 2018, subject to approval by Hercules’ Investment Committee. The Term Loan will mature on December 1, 2020.
On December 31, 2016, we entered into Warrant and Note Cancellation and Share Forfeiture Agreements (the “Cancellation and Forfeiture Agreements”) with certain investors (the “Investors”) that held an aggregate of 7,838,259 shares of Common Stock and certain of the Warrants granting the right to purchase an aggregate of 1,137,316 shares of Common Stock.  The Investors had also issued to us secured promissory notes (the “Notes”) in an aggregate principal amount of $53.5 million, of which $43.5 million was then outstanding.  Pursuant to the Cancellation and Forfeiture Agreements, effective

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December 31, 2016, the Warrants held by the Investors and the Notes were cancelled and the shares of Common Stock held by the Investors were forfeited and returned to us.
On April 13, 2017, we entered into the Underwriting Agreement with the Underwriters, relating to the Offering of 23,625,084 shares of our common stock. The public offering price was $2.00 per share of our common stock and the Underwriters agreed to purchase the shares of common stock pursuant to the Underwriting Agreement at a price of $1.8571 per share. Under the terms of the Underwriting Agreement, we also granted to the Underwriters an option, exercisable in whole or in part at any time for a period of 30 days from the date of the closing of the Offering, to purchase up to an additional 3,543,763 shares of our common stock at the public offering price. 
On April 19, 2017, the Offering was completed and resulted in net proceeds of approximately $43.5 million (excluding any sale of shares of common stock pursuant to the option granted to the Underwriters), after deducting underwriting discounts and commissions and estimated Offering expenses payable by us.
If we raise additional funds by issuing equity securities, substantial dilution to existing stockholders would result. If we raise additional funds by incurring debt financing, the terms of the debt may involve significant cash payment obligations as well as covenants and specific financial ratios that may restrict our ability to operate our business.
Off-Balance Sheet Arrangements
Since our inception through June 30, 2017 , we have not engaged in any off-balance sheet arrangements as defined in Item 303(a)(4) of Regulation S-K.
New Accounting Pronouncements
Refer to Note 1, “Nature of Operations and Business Activities,” in the accompanying notes to the condensed consolidated financial statements for a discussion of recent accounting pronouncements.
Item 3.    Quantitative and Qualitative Disclosures About Market Risk.  
Interest Rate Risk. Our exposure to market risk is confined to our cash and cash equivalents. We have cash and cash equivalents and invest primarily in high-quality money market funds, which we believe are subject to limited credit risk. Due to the low risk profile of our investments, an immediate 10% change in interest rates would not have a material effect on the fair market value of our portfolio. The interest rate under our loan and security agreement with Hercules Capital, Inc. is calculated at a prime-based variable rate, currently at 10.0%. We do not believe that we have any material exposure to interest rate risk arising from our investments.  
Capital Market Risk. We currently do not have significant revenues from grants or sales and services and we have no product revenues from our planned principal operations and therefore depend on funds raised through other sources. One source of funding is through future debt or equity offerings. Our ability to raise funds in this manner depends upon, among other things, capital market forces affecting our stock price.
Item 4.    Controls and Procedures.
We maintain disclosure controls and procedures that are designed to ensure that information required to be disclosed in our reports filed under the Securities Exchange Act of 1934, as amended (the “Exchange Act”), is recorded, processed, summarized and reported within the time periods specified in the SEC’s regulations, rules and forms and that such information is accumulated and communicated to our management, including our principal executive officer and principal financial officer, as appropriate, to allow for timely decisions regarding required disclosure.
In designing and evaluating the disclosure controls and procedures, management recognizes that any controls and procedures, no matter how well designed and operated, can provide only reasonable assurance of achieving the desired control objectives, and management is required to apply its judgment in evaluating the cost-benefit relationship of possible controls and procedures. As required by Rule 13a-15(b) promulgated by the SEC under the Exchange Act, we carried out an evaluation, under the supervision and with the participation of our management, including our principal executive officer and principal financial officer, of the effectiveness of the design and operation of our disclosure controls and procedures as of the end of the period covered by this Quarterly Report on Form 10-Q. Based on the foregoing, our principal executive officer and principal financial officer concluded that our disclosure controls and procedures were not effective as of the end of the period covered by this Quarterly Report on Form 10-Q as a result of the material weakness described below.

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In March 2017, in connection with the preparation of our 2016 financial statements, we identified certain purchase agreements which contained terms for contingent consideration that were not identified timely and accounted for in our historical financial statements on a timely basis.  Further, certain other purchase agreements containing terms for contingent consideration were identified timely, but we failed to adjust the liabilities for changes in fair value at each subsequent reporting period. Accordingly, we did not appropriately account for liabilities for contingent consideration payable and the related adjustments to earnings.
Based on these findings and the criteria discussed above, our management identified a material weakness in our review controls over unusual or non-recurring and significant transactions.  Specifically, our controls were not properly designed to provide reasonable assurance that we (1) timely identify and assess the accounting implications of terms in unusual or non-recurring agreements and (2) reassess the valuation of associated assets or liabilities at the end of each reporting period.
As a result of the material weakness, we have initiated and will continue to implement remediation measures including, but not limited to, improving centralized documentation control, improving the internal communication procedures between senior executive management, accounting personnel, and related business owners, leveraging external accounting experts as appropriate, and strengthening policies and procedures related to the transferring of responsibilities and the handoff of personnel duties. We believe that our remediation measures will ensure that we timely identify terms in agreements that could have material accounting implications, assesses the accounting and disclosures implications of the terms, and accounts for such items in the financial statements appropriately.  Any failure to implement these improvements to our internal control over financial reporting may render our future assertions as ineffective and potentially impact our ability to produce reliable financial reports, effectively manage the company or prevent fraud, and could potentially harm our business and our performance.
Changes in Internal Control Over Financial Reporting
There has been no change in our internal control over financial reporting during the quarter ended June 30, 2017 that has materially affected, or is reasonably likely to materially affect, our internal control over financial reporting. As identified above, a material weakness was identified in our internal control over financial reporting as of June 30, 2017 .  Our plans for remediating such material weakness, which would constitute changes in our internal control over financial reporting prospectively, are also enumerated above.

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PART II. OTHER INFORMATION
Item 1.    Legal Proceedings.
To the best of our knowledge, we (the “Company”) are not a party to any legal proceedings that, individually or in the aggregate, are deemed to be material to our financial condition or results of operations.  
In the normal course of business, we may be named as a defendant in one or more lawsuits. We are not a party to any outstanding material litigation and management is currently not aware of any legal proceedings that, individually or in the aggregate, are deemed to be material to our financial condition or results of operations.  
Derivative Action Litigation
On April 25, 2016, Wildcat Liquid Alpha, LLC (“WLA”) filed a complaint in the Court of Chancery of the State of Delaware seeking an order compelling the Company to provide WLA with certain documents, books and records for inspection and copying pursuant to an April 11, 2016 demand made by WLA (the “Inspection Demand Action”). On May 13, 2016, WLA filed a derivative action in the Court of Chancery of the State of Delaware (the “WLA Action” and, together with the Inspection Demand Action, the “Actions”) against each of the members of the Company’s board of directors at the time, Henry Ji, William S. Marth, Kim D. Janda, Jaisim Shah, David H. Deming, and Douglas Ebersole (the “Prior Board”) and against the Company as nominal defendant.  After the members of the Prior Board and the Company moved to dismiss, on August 12, 2016, WLA filed an amended complaint containing both direct and derivative claims against each of the members of the Prior Board and against the Company as nominal defendant, alleging, among other things: (1) breach of fiduciary duty with respect to the formation of, and certain options and warrants issued by, certain of the Company’s subsidiaries to Dr. Ji and members of the Prior Board (the “Subsidiary Options Claim”); (2) breach of fiduciary duty with respect to the Company’s prior announcement that it had entered into a voting agreement with Yuhan Corporation (“Yuhan”) in connection with a transaction through which it purchased $10 million of shares of the Company’s common stock and warrants (the “Yuhan Agreement Claim”); (3) waste of corporate assets regarding the foregoing; (4) unjust enrichment regarding the foregoing; and (5) violation of 8 Del. C. § 160 based on the Yuhan voting agreement.  
On March 17, 2017, the Company, the members of the Prior Board and WLA entered into a confidential settlement agreement and release (the “Settlement Agreement”) pursuant to which, among other things, each party agreed to forever release and not to sue the other party with respect to the claims asserted in the Actions and WLA agreed to take all actions to seek to dismiss the Actions without prejudice within ten business days following the execution of the Settlement Agreement. As part of the Settlement Agreement, the Company also agreed (1) to terminate all options and warrants currently outstanding in Company subsidiaries that have been granted to Dr. Ji and any other director of the Company no later than 60 days after the Company’s next annual meeting of stockholders, (2) to grant WLA the right to designate a representative to attend all meetings of the Company’s board of directors in a nonvoting observer capacity, (3) to act in good faith to attempt to add two additional independent directors to the Company’s board of directors, and (4) to pay $400,000 as reimbursement for WLA’s out of pocket fees and expenses.  In addition, WLA agreed to comply with a two-year standstill period, during which WLA is prohibited from engaging in certain actions relating to controlling or influencing the management of the Company.
On May 31, 2017, the Court of Chancery of the State of Delaware entered an order providing for dismissal of the Actions without prejudice pursuant to the terms of the Settlement Agreement, to be effective upon the Company submitting to the Court of Chancery of the State of Delaware a notice of the filing of a Current Report on Form 8-K with the Securities and Exchange Commission, which was filed on June 1, 2017.
On September 8, 2016, Yvonne Williams filed an action both derivatively and on behalf of a purported class of stockholders in the Court of Chancery of the State of Delaware against each of the members of the Prior Board; George Ng, the Company’s Executive Vice President, Chief Administrative Officer, and Chief Legal Officer; Jeffrey Su, the Company’s Executive Vice President & Chief Operating Officer; and the Company as nominal defendant, alleging: (1) breach of fiduciary duty with respect to the Subsidiary Options Claim; and (2) breach of fiduciary duty with respect to the Yuhan Agreement Claim  (the “Williams Action”). The Company is unable to determine whether any loss will occur with respect to the Williams Action or to estimate the range of such potential loss; therefore, no amount of loss has been accrued by the Company as of the date of filing of this Quarterly Report on Form 10-Q. Furthermore, there is no guarantee that the Company will prevail in this suit or receive any relief if it does prevail.
Immunomedics Litigation
On June 26, 2015, Immunomedics, Inc. (“Immunomedics”) filed a complaint in the United States District Court for the District of New Jersey (the “Immunomedics Action”) against the Board of Directors of Roger Williams Medical Center, Dr. Richard P. Junghans, Dr. Steven C. Katz, the Office of the Board of Advisors of Tufts University School of Medicine, and one

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or more individuals or entities to be identified later.  This complaint (the “Initial Complaint”) alleged, among other things: (1) breach of contract; (2) breach of covenant of good faith and fair dealing; (3) tortious interference with prospective economic gain; (4) tortious interference with contracts; (5) misappropriation; (6) conversion; (7) bailment; (8) negligence; (9) vicarious liability; and (10) patent infringement.  Overall, the allegations in the Initial Complaint were generally directed to an alleged material transfer agreement dated December 2008 and Immunomedics’ alleged request for the return of certain alleged research material, as well as the alleged improper use and conversion of such research materials outside the scope of the material transfer agreement.  
On October 22, 2015, Immunomedics filed an amended complaint (the “First Amended Complaint”), which, among other things, no longer named the Board of Directors of Roger Williams Medical Center and The Office of the Board of Advisors of Tufts University School of Medicine as defendants. Roger Williams Medical Center and Tufts Medical Center were added as new defendants.  On January 14, 2016, Immunomedics filed a second amended complaint (the “Second Amended Complaint”), which, among other things, no longer named Tufts Medical Center as a defendant.  In addition, the Second Amended Complaint contained allegations directed to two additional alleged material transfer agreements dated September 1993 and May 2010, respectively, and also added an allegation of unjust enrichment.  The Second Amended Complaint also no longer asserted claims for (1) breach of covenant of good faith and fair dealing; (2) misappropriation; (3) bailment; (4) negligence; and (5) vicarious liability.  
On October 12, 2016, Immunomedics filed a third amended complaint (the “Third Amended Complaint”), which added the Company, TNK Therapeutics, Inc. (“TNK”), BDL Products, Inc. (“BDL”), and CARgenix Holdings LLC (“CARgenix”) as defendants.  TNK is a subsidiary of the Company and purchased BDL and CARgenix in August 2015.  The Third Amended Complaint includes, among other things, allegations against the Company, TNK, BDL and CARgenix regarding (1) conversion; (2) tortious interference; and (3) unjust enrichment.  On December 2, 2016, the Company, TNK, BDL, and CARgenix filed a motion to dismiss Immunomedics’s complaint against them for lack of personal jurisdiction.  On January 25, 2017, the District of New Jersey granted this motion, and the Company, TNK, BDL and CARgenix were dismissed as defendants from the case.  The Immunomedics Action remains pending in the District of New Jersey against defendants Roger Williams Medical Center, Dr. Junghans, and Dr. Katz.  A trial date has not yet been set. The Company believes that the Immunomedics Action is without merit, and will vigorously defend itself against this and any further actions. However, should Immunomedics prevail against the Company, Roger Williams Medical Center or other defendants, certain patent rights optioned, owned and/or licensed by the Company could be at risk of invalidity or enforceability, or the litigation could otherwise adversely impact the Company’s ownership or other rights in certain intellectual property.  At this point in time, the Company is unable to determine whether any loss will occur with respect to the Immunomedics Action or to estimate the range of such potential loss; therefore, no amount of loss has been accrued by the Company as of the date of filing of this Quarterly Report on Form 10-Q.
Item 1A.    Risk Factors.
Our Annual Report on Form 10-K for the year ended December 31, 2016, Part I –Item 1A, Risk Factors, describes important risk factors that could cause our business, financial condition, results of operations and growth prospects to differ materially from those indicated or suggested by forward-looking statements made in this Quarterly Report on Form 10-Q or presented elsewhere by management from time to time. Except as set forth below, there have been no material changes in our risk factors since the filing of our Annual Report on Form 10-K for the year ended December 31, 2016. Additional risks and uncertainties not currently known to us or that we currently deem to be immaterial may also materially and adversely affect our business.
Risks Related to Our Business and Industry
We are heavily dependent on the success of our technologies and product candidates, and we cannot give any assurance that any of our product candidates will receive regulatory approval, which is necessary before they can be commercialized.
To date, we have invested a significant portion of our efforts and financial resources in the acquisition and development of our product candidates. We have not demonstrated our ability to perform the functions necessary for the successful acquisition, development or commercialization of the technologies we are seeking to develop. As an early stage company, we have limited experience and have not yet demonstrated an ability to successfully overcome many of the risks and uncertainties frequently encountered by companies in new and rapidly evolving fields, particularly in the biopharmaceutical area. Our future success is substantially dependent on our ability to successfully develop, obtain regulatory approval for, and then successfully commercialize such product candidates. Our product candidates are currently in preclinical development or in clinical trials. Our business depends entirely on the successful development and commercialization of our product candidates, which may never occur. We currently generate no revenues from sales of any drugs, and we may never be able to develop or commercialize a marketable drug.

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The successful development, and any commercialization, of our technologies and any product candidates would require us to successfully perform a variety of functions, including:
developing our technology platform;
seeking and obtaining intellectual property and/or proprietary rights to our technology and/or the technology of others;
identifying, developing, manufacturing and commercializing product candidates;
entering into successful licensing and other arrangements with product development partners;
participating in regulatory approval processes;
formulating and manufacturing products; and
conducting sales and marketing activities.
Our operations have been limited to organizing our company, acquiring, developing and securing our proprietary technology and identifying and obtaining early preclinical data or clinical data for various product candidates. These operations provide a limited basis for you to assess our ability to continue to develop our technology, identify product candidates, develop and commercialize any product candidates we are able to identify and enter into successful collaborative arrangements with other companies, as well as for you to assess the advisability of investing in our securities. Each of these requirements will require substantial time, effort and financial resources.
Each of our product candidates will require additional preclinical or clinical development, management of preclinical, clinical and manufacturing activities, regulatory approval in multiple jurisdictions, obtaining manufacturing supply, building of a commercial organization, and significant marketing efforts before we generate any revenues from product sales. We are not permitted to market or promote any of our product candidates before we receive regulatory approval from the U.S. Food and Drug Administration (the “FDA”), the United Kingdom’s Medicines and Healthcare Products Regulatory Agency (the “MHRA”), the European Medicines Agency (“EMA”) or comparable foreign regulatory authorities, and we may never receive such regulatory approval for any of our product candidates. In addition, our product development programs contemplate the development of companion diagnostics by our third-party collaborators. Companion diagnostics are subject to regulation as medical devices and must themselves be approved for marketing by the FDA, the MHRA, the EMA or certain other foreign regulatory agencies before we may commercialize our product candidates.
The regulatory approval processes of the FDA, the MHRA, the EMA and comparable foreign authorities are lengthy, time consuming and inherently unpredictable, and if we are ultimately unable to obtain regulatory approval for our product candidates, our business will be substantially harmed.
The time required to obtain approval from the FDA, the MHRA, the EMA and comparable foreign authorities is unpredictable but typically takes many years following the commencement of clinical trials and depends upon numerous factors, including the substantial discretion of the regulatory authorities. In addition, approval policies, regulations, or the type and amount of clinical data necessary to gain approval may change during the course of a product candidate’s clinical development and may vary among jurisdictions. We have not obtained regulatory approval for any product candidate and it is possible that none of our existing product candidates or any product candidates we may seek to develop in the future will ever obtain regulatory approval.
We may fail to receive regulatory approval for our product candidates for many reasons, including the following:
the FDA, the MHRA, the EMA or comparable foreign regulatory authorities may disagree with the design or implementation of our clinical trials;
we may be unable to demonstrate to the satisfaction of the FDA, the MHRA, the EMA or comparable foreign regulatory authorities that a product candidate is safe and effective for its proposed indication;
the results of clinical trials may not meet the level of statistical significance required for approval by the FDA, the MHRA, the EMA or comparable foreign regulatory authorities;
the FDA, the MHRA, the EMA or comparable foreign regulatory authorities may disagree with our interpretation of data from preclinical studies or clinical trials;
the data collected from clinical trials of our product candidates may not be sufficient to support the submission of an NDA, a marketing authorization application (“MAA”) or other submission or to obtain regulatory approval in the U.S., the United Kingdom, the European Union or elsewhere;
the FDA, the MHRA, the EMA or comparable foreign regulatory authorities may fail to approve the manufacturing processes or facilities of third-party manufacturers with which we contract for clinical and commercial supplies;
the FDA, the MHRA, the EMA or comparable foreign regulatory authorities may fail to approve the companion diagnostics we contemplate developing with partners; and
the approval policies or regulations of the FDA, the MHRA, the EMA or comparable foreign regulatory authorities may significantly change in a manner rendering our clinical data insufficient for approval.

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This lengthy approval process as well as the unpredictability of future clinical trial results may result in our failing to obtain regulatory approval to market our product candidates, which would significantly harm our business, results of operations and prospects.
In addition, even if we were to obtain approval, regulatory authorities may approve any of our product candidates for fewer or more limited indications than we request, may not approve the price we intend to charge for our products, may grant approval contingent on the performance of costly post-marketing clinical trials, or may approve a product candidate with a label that does not include the labeling claims necessary or desirable for the successful commercialization of that product candidate. Any of the foregoing scenarios could materially harm the commercial prospects for our product candidates.
Other than a new drug application submitted by Scilex for Scilex’s lead product candidate, ZTlido TM , we have not previously submitted a BLA or an NDA to the FDA, an MAA to the MHRA or the EMA or similar drug approval filings to comparable foreign authorities, for any product candidate, and we cannot be certain that any of our product candidates will be successful in clinical trials or receive regulatory approval. Further, our product candidates may not receive regulatory approval even if our clinical trials are successful. If we do not receive regulatory approvals for our product candidates, we may not be able to continue our operations. Even if we successfully obtain regulatory approvals to market one or more of our product candidates, our revenues will be dependent, in some instances, upon our collaborators’ ability to obtain regulatory approval of the companion diagnostics to be used with our product candidates, as well as the size of the markets in the territories for which we gain regulatory approval and have commercial rights. If the markets for patients that we are targeting for our product candidates are not as significant as we estimate, we may not generate significant revenues from sales of such products, if approved.
We plan to seek regulatory approval to commercialize our product candidates in the U.S., the United Kingdom, the European Union and in additional foreign countries. While the scope of regulatory approval is similar in other countries, to obtain separate regulatory approval in many other countries we must comply with numerous and varying regulatory requirements of such countries regarding safety and efficacy and governing, among other things, clinical trials and commercial sales, pricing and distribution of our product candidates, and we cannot predict success in these jurisdictions. Further, the United Kingdom has voted to withdraw from the European Union. We cannot predict what consequences the withdrawal of the United Kingdom from the European Union might have on the regulatory frameworks of the United Kingdom or the European Union, or on our future operations, if any, in these jurisdictions.
We rely on third parties to conduct our preclinical and clinical trials. If these third parties do not successfully perform their contractual legal and regulatory duties or meet expected deadlines, we may not be able to obtain regulatory approval for or commercialize our product candidates and our business could be substantially harmed.
We have relied upon and plan to continue to rely upon third-party CROs to monitor and manage data for our ongoing preclinical and clinical programs. We rely on these parties for execution of our preclinical and clinical trials, and control only certain aspects of their activities. Nevertheless, we are responsible for ensuring that each of our studies is conducted in accordance with the applicable protocol, legal, regulatory and scientific standards, and our reliance on the CROs does not relieve us of our regulatory responsibilities. We and our CROs are required to comply with current good clinical practices (“cGCP”), which are regulations and guidelines enforced by the FDA, the Competent Authorities of the Member States of the European Economic Area, and comparable foreign regulatory authorities for all of our product candidates in clinical development.
Regulatory authorities enforce these cGCPs through periodic inspections of trial sponsors, principal investigators and trial sites. If we or any of our CROs fail to comply with applicable cGCPs, the clinical data generated in our clinical trials may be deemed unreliable and the FDA, the MHRA, the EMA or comparable foreign regulatory authorities may require us to perform additional clinical trials before approving our marketing applications or may not approve our marketing applications. We cannot assure you that upon inspection by a given regulatory authority, such regulatory authority will determine that any of our clinical trials comply with cGCP regulations. In addition, our clinical trials must be conducted with product produced under current good manufacturing practices (“cGMP”) regulations. Our failure to comply with these regulations may require us to repeat clinical trials, which would delay the regulatory approval process.
If any of our relationships with these third-party CROs terminate, we may not be able to enter into arrangements with alternative CROs or to do so on commercially reasonable terms. In addition, our CROs are not our employees, and except for remedies available to us under our agreements with such CROs, we cannot control whether or not they devote sufficient time and resources to our on-going clinical, nonclinical and preclinical programs. If CROs do not successfully carry out their contractual duties or obligations or meet expected deadlines, if they need to be replaced or if the quality or accuracy of the clinical data they obtain is compromised due to the failure to adhere to our clinical protocols, regulatory requirements or for

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other reasons, our clinical trials may be extended, delayed or terminated and we may not be able to obtain regulatory approval for or successfully commercialize our product candidates. As a result, our results of operations and the commercial prospects for our product candidates would be harmed, our costs could increase and our ability to generate revenues could be delayed.
Switching or adding additional CROs involves additional cost and requires management time and focus. In addition, there is a natural transition period when a new CRO commences work. As a result, delays occur, which can materially impact our ability to meet our desired clinical development timelines. Though we carefully manage our relationships with our CROs, there can be no assurance that we will not encounter similar challenges or delays in the future or that these delays or challenges will not have a material adverse impact on our business, financial condition and prospects.
If we cannot compete successfully against other biotechnology and pharmaceutical companies, we may not be successful in developing and commercializing our technology and our business will suffer.
The biotechnology and pharmaceutical industries are characterized by intense competition and rapid technological advances, both in the U.S. and internationally. In addition, the competition in the oncology and pain management markets, and other relevant markets, is intense. Even if we are able to develop our product candidates, proprietary platform technology and/or additional antibody libraries, each will compete with a number of existing and future technologies and product candidates developed, manufactured and marketed by others. Specifically, we will compete against fully integrated pharmaceutical companies and smaller companies that are collaborating with larger pharmaceutical companies, academic institutions, government agencies and other public and private research organizations. Many of these competitors have validated technologies with products already FDA-approved or in various stages of development. In addition, many of these competitors, either alone or together with their collaborative partners, operate larger research and development programs and have substantially greater financial resources than we do, as well as significantly greater experience in:
developing product candidates and technologies generally;
undertaking preclinical testing and clinical trials;
obtaining FDA and other regulatory approvals of product candidates;
formulating and manufacturing product candidates; and
launching, marketing and selling product candidates.
Many of our competitors have substantially greater financial, technical and other resources, such as larger research and development staff and experienced marketing and manufacturing organizations. Additional mergers and acquisitions in the biotechnology and pharmaceutical industries may result in even more resources being concentrated in our competitors. As a result, these companies may obtain regulatory approval more rapidly than we are able and may be more effective in selling and marketing their products as well. Smaller or early-stage companies or generic or biosimilar pharmaceutical manufacturers may also prove to be significant competitors, particularly through collaborative arrangements with large, established companies. Competition may increase further as a result of advances in the commercial applicability of technologies and greater availability of capital for investment in these industries. Our competitors may succeed in developing, acquiring or licensing on an exclusive basis drug products that are more effective or less costly than any drug candidate that we are currently developing or that we may develop. If approved, our product candidates will face competition from commercially available drugs as well as drugs that are in the development pipelines of our competitors and later enter the market.
Established pharmaceutical companies may invest heavily to accelerate discovery and development of novel compounds or to in-license novel compounds that could make our product candidates less competitive. In addition, any new product that competes with an approved product must demonstrate compelling advantages in efficacy, convenience, tolerability and safety in order to overcome price competition and to be commercially successful. Accordingly, our competitors may succeed in obtaining patent protection, receiving FDA, the MHRA, the EMA or other regulatory approval or discovering, developing and commercializing medicines before we do, which would have a material adverse impact on our business. If our technologies fail to compete effectively against third party technologies, our business will be adversely impacted.
We expect that our ability to compete effectively will depend upon our ability to:
successfully and efficiently complete clinical trials and submit for and obtain all requisite regulatory approvals in a cost-effective manner;
obtain and maintain a proprietary position for our products and manufacturing processes and other related product technology;
attract and retain key personnel;
develop relationships with physicians prescribing these products; and
build an adequate sales and marketing infrastructure for our product candidates.

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Because we will be competing against significantly larger companies with established track records, we will have to demonstrate that, based on experience, clinical data, side-effect profiles and other factors, our product candidates, if approved, are competitive with other products.
Our global operations are exposed to political and economic risks, commercial volatility and events beyond our control in the countries in which we operate, some of which may be enhanced by our recent acquisition of Virttu Biologics Limited.
On April 27, 2017, we acquired Virttu Biologics Limited, which is based in the United Kingdom. In addition to challenges specific to the United States, our operations, including but not limited to our operations outside of the United States, are subject to a variety of political and economic risks, including risks arising from:
unexpected changes in international or domestic legal, regulatory or governmental requirements or regulations, including related to intellectual property or the biopharmaceutical industry;
unexpected increases in taxes or tariffs;
trade protection measures or import or export licensing requirements;
the inability to obtain necessary foreign regulatory or pricing approvals of products in a timely manner;
fluctuations in foreign currency exchange rates;
difficulties in staffing and managing international operations;
less favorable intellectual property or other applicable laws;
the effects of the implementation of the United Kingdom’s decision to voluntarily depart from the European Union;
currency controls that restrict or prohibit the payment of funds or the repatriation of earnings to the United States;
increased costs of compliance with general business and tax regulations in these countries or regions;
divergent legal systems and regulatory frameworks; and
political and economic instability or corruption.

These risks and others as described in our Annual Report on Form 10-K for the year ended December 31, 2016
may have a material adverse effect on our global operations and on our business and financial condition.
Item 6.    Exhibits.
The exhibits listed in the Exhibit Index immediately preceding the exhibits are filed as part of this Quarterly Report on Form 10-Q and such Exhibit Index is incorporated herein by reference.

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SIGNATURES
Pursuant to the requirements of the Securities Exchange Act of 1934, as amended, the registrant has duly caused this report to be signed on its behalf by the undersigned thereunto duly authorized.
 
 
 
Sorrento Therapeutics, Inc.
 
 
 
 
Date:
August 9, 2017
By:  
/s/ Henry Ji, Ph.D. 
 
 
 
Henry Ji, Ph.D.
 
 
 
Chairman of the Board of Directors, Chief Executive Officer & President
 
 
 
(Principal Executive Officer)
 
 
 
 
Date:
August 9, 2017
By:  
/s/ Dean Ferrigno
 
 
 
Dean Ferrigno
 
 
 
Chief Accounting Officer
 
 
 
(Principal Financial and Accounting Officer)

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EXHIBIT INDEX
2.1*
 
Share Purchase Agreement, dated April 27, 2017, by and among Sorrento Therapeutics, Inc., TNK Therapeutics, Inc., Virttu Biologics Limited, the shareholders of Virttu Biologics Limited and Dayspring Ventures Limited, as representative of the shareholders of Virttu Biologics Limited (incorporated by reference to Exhibit 2.1 to the Registrant’s Current Report on Form 8-K filed with the SEC on April 28, 2017).
 
 
 
4.1
 
Registration Rights Agreement, dated April 27, 2017, by and among Sorrento Therapeutics, Inc. and the persons party thereto (incorporated by reference to Exhibit 4.1 to the Registrant’s Current Report on Form 8-K filed with the SEC on April 28, 2017).
 
 
 
10.1
 
Fifth Amendment to Loan and Security Agreement, dated April 13, 2017, among Sorrento Therapeutics, Inc., certain of its domestic subsidiaries, and Hercules Capital, Inc.
 
 
 
10.2
 
Sixth Amendment to Loan and Security Agreement, dated April 27, 2017, among Sorrento Therapeutics, Inc., certain of its domestic subsidiaries, and Hercules Capital, Inc.
 
 
 
10.3+
 
Amended and Restated Employment Agreement between Sorrento Therapeutics, Inc. and Henry Ji, Ph.D., dated May 9, 2017 (incorporated by reference to Exhibit 10.5 to the Registrant’s Quarterly Report on Form 10-Q filed with the SEC on May 15, 2017).
 
 
 
10.4**
 
Contribution Agreement, dated as of June 12, 2017, by and among Sorrento Therapeutics, Inc., TNK Therapeutics, Inc. and Celularity, Inc.
 
 
 
10.5
 
Amendment No. 1 to Promissory Note, dated as of June 12, 2017, by and between Sorrento Therapeutics, Inc., TNK Therapeutics, Inc. and Celularity, Inc.
 
 
 
10.6**
 
Amendment No. 1 to Contribution Agreement, dated as of June 30, 2017, by and among Sorrento Therapeutics, Inc., TNK Therapeutics, Inc. and Celularity, Inc.
 
 
 
10.7
 
Amendment No. 2 to Promissory Note, dated as of June 30, 2017, by and between Sorrento Therapeutics, Inc., TNK Therapeutics, Inc. and Celularity, Inc.
 
 
 
31.1
  
Certification of Henry Ji, Ph.D., Principal Executive Officer, pursuant to Section 302 of the Sarbanes-Oxley Act of 2002, as amended.
 
 
 
31.2
  
Certification of Dean Ferrigno, Principal Financial Officer, pursuant to Section 302 of the Sarbanes-Oxley Act of 2002, as amended.
 
 
 
32.1
  
Certification of Henry Ji, Ph.D., Principal Executive Officer, and Dean Ferrigno, Principal Financial Officer, pursuant to Section 906 of the Sarbanes-Oxley Act of 2002, as amended.
 
 
 
101.INS
  
XBRL Instance Document
 
 
 
101.SCH
  
XBRL Taxonomy Extension Schema Document
 
 
 
101.CAL
  
XBRL Taxonomy Extension Calculation Linkbase Document
 
 
 
101.DEF
  
XBRL Taxonomy Extension Definition Linkbase Document
 
 
 
101.LAB
  
XBRL Taxonomy Extension Label Linkbase Document
 
 
 
101.PRE
  
XBRL Taxonomy Extension Presentation Linkbase Document
*
Non material schedules and exhibits have been omitted pursuant to Item 601(b)(2) of Regulation S-K. The Registrant hereby undertakes to supplementally furnish copies of any of the omitted schedules and exhibits upon request by the SEC.

54



**
The Registrant has requested confidential treatment with respect to certain portions of the exhibit. Omitted portions have been filed separately with the SEC.
+
Management contract or compensatory plan.


55
Exhibit 10.1
Execution Version

FIFTH AMENDMENT TO LOAN AND SECURITY AGREEMENT

THIS FIFTH AMENDMENT TO LOAN AND SECURITY AGREEMENT (this “ Amendment ”), dated as of April 13, 2017 (the “ Fifth Amendment Effective Date ”), is entered into by and among Sorrento Therapeutics, Inc., a Delaware corporation (“ Parent ”), Concortis Biosystems, Corp., a Delaware corporation, Ark Animal Health, Inc., a Delaware corporation, TNK Therapeutics, Inc., a Delaware corporation, Sorrento Biologics, Inc., a Delaware corporation, Scintilla Pharmaceuticals, Inc., a Delaware corporation, LA Cell, Inc., a Delaware corporation, SiniWest Holding Corp., a Delaware corporation, Levena Biopharma US, Inc., a Delaware corporation, BioServ Corporation (formerly known as Sorrento BioServices, Inc.), a Delaware corporation, Scilex Pharmaceuticals Inc., a Delaware corporation, SNAN Holdco LLC, a Delaware limited liability company and each of their Qualified Subsidiaries (together with “Parent” hereinafter collectively referred to as the “ Borrower ”), the several banks and other financial institutions or entities from time to time parties thereto as Lender, constituting the Required Lenders, and HERCULES CAPITAL, INC., formerly known as Hercules Technology Growth Capital, Inc., a Maryland corporation, in its capacity as administrative agent and collateral agent for itself and the Lender (in such capacity, together with its successors and assigns in such capacity, “ Agent ”).
The Borrower, the Lender and Agent are parties to a Loan and Security Agreement dated as of November 23, 2016 (as amended by that certain First Amendment to Loan and Security Agreement dated as of December 27, 2016, that certain Second Amendment to Loan and Security Agreement dated as of March 2, 2017, that certain Third Amendment to Loan and Security Agreement dated as of March 15, 2017, that certain Fourth Amendment to Loan and Security Agreement dated as of March 23, 2017, and as may be further amended, restated or modified from time to time, the “ Loan and Security Agreement ”). The Borrower has requested that the Lender agree to certain amendments to the Loan and Security Agreement. The Lender has agreed to such request, subject to the terms and conditions hereof.
Accordingly, the parties hereto agree as follows:
SECTION 1 Definitions; Interpretation.
(a)      Terms Defined in Loan and Security Agreement . All capitalized terms used in this Amendment (including in the recitals hereof) and not otherwise defined herein shall have the meanings assigned to them in the Loan and Security Agreement.
(b)      Interpretation . The rules of interpretation set forth in Section 1.1 of the Loan and Security Agreement shall be applicable to this Amendment and are incorporated herein by this reference.
SECTION 2      Amendments to the Loan and Security Agreement. The Loan and Security Agreement shall be amended by amending and restating the following definition in its entirety as follows effective as of the Fifth Amendment Effective Date:

1




(i)      “Initial Fundraising Requirement” means Borrower’s receipt after the Closing Date and on or prior to April 19, 2017, of at least Forty Three Million Two Hundred Fifty Thousand Dollars ($43,250,000) of unrestricted (including not subject to any clawback, redemption, escrow or similar contractual restriction, but excluding any restriction in favor of Agent) net cash proceeds from (a) one or more Equity Events closing after the Closing Date and prior to April 14, 2017 of (x) Borrower (other than Parent) with investors and with terms and conditions reasonably satisfactory to Agent or (y) Parent, or (b) the collection of the 2016 PIPE Notes Receivable in cash outstanding as of the Closing Date.
(b)      References Within Loan and Security Agreement . Each reference in the Loan and Security Agreement to “this Agreement” and the words “hereof,” “herein,” “hereunder,” or words of like import, shall mean and be a reference to the Loan and Security Agreement as amended by this Amendment.
SECTION 3      Conditions of Effectiveness. The effectiveness of Section 2 of this Amendment shall be subject to the satisfaction of each of the following conditions precedent:
(a)      Fees and Expenses . The Borrower shall have paid (i) all attorney fees and other costs and expenses then due in accordance with Section 5(e) , and (ii) all other fees, costs and expenses, if any, due and payable as of the Fifth Amendment Effective Date under the Loan and Security Agreement.
(b)      This Amendment . Agent shall have received this Amendment, executed by Agent, the Lender and the Borrower.
(c)      Representations and Warranties; No Default . On the Fifth Amendment Effective Date, after giving effect to the amendment of the Loan and Security Agreement contemplated hereby:
(i)      The representations and warranties contained in Section 4 shall be true and correct in all material respects on and as of the Fifth Amendment Effective Date as though made on and as of such date; and
(ii)      There exist no Events of Default or events that with the passage of time would result in an Event of Default.
SECTION 4      Representations and Warranties . To induce Agent and Lender to enter into this Amendment, the Borrower hereby confirms, as of the date hereof, (a) that the representations and warranties made by it in Section 5 of the Loan and Security Agreement and in the other Loan Documents are true and correct in all material respects; provided , however , that such materiality qualifier shall not be applicable to any representations and warranties that already are qualified or modified by materiality in the text thereof; (b) that there has not been and there does not exist a Material Adverse Effect; and (c) that the information included in the Perfection Certificate delivered to Agent on the Effective Date remains true and correct. For the purposes of this Section 4 , any representations and warranties which relate solely to an earlier date shall not be deemed confirmed and restated as of the date hereof (provided that such representations and warranties shall be true, correct and complete in all material respects as of such earlier date).

2

US-DOCS\85467854.2



SECTION 5      Miscellaneous.
(a)      Loan Documents Otherwise Not Affected; Reaffirmation . Except as expressly amended pursuant hereto or referenced herein, the Loan and Security Agreement and the other Loan Documents shall remain unchanged and in full force and effect and are hereby ratified and confirmed in all respects. The Lender’s and Agent’s execution and delivery of, or acceptance of, this Amendment shall not be deemed to create a course of dealing or otherwise create any express or implied duty by any of them to provide any other or further amendments, consents or waivers in the future. The Borrower hereby reaffirms the grant of security under Section 3.1 of the Loan and Security Agreement and hereby reaffirms that such grant of security in the Collateral secures all Secured Obligations under the Loan and Security Agreement, including without limitation any Term Loans funded on or after the Fifth Amendment Effective Date, as of the date hereof.
(b)      Conditions . For purposes of determining compliance with the conditions specified in Section 3 , each Lender that has signed this Amendment shall be deemed to have consented to, approved or accepted or to be satisfied with, each document or other matter required thereunder to be consented to or approved by or acceptable or satisfactory to a Lender unless Agent shall have received notice from such Lender prior to the Fifth Amendment Effective Date specifying its objection thereto.
(c)      Release . In consideration of the agreements of Agent and each Lender contained herein and for other good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, Borrower, on behalf of itself and its successors, assigns, and other legal representatives, hereby fully, absolutely, unconditionally and irrevocably releases, remises and forever discharges Agent and each Lender, and its successors and assigns, and its present and former shareholders, affiliates, subsidiaries, divisions, predecessors, directors, officers, attorneys, employees, agents and other representatives (Agent, Lenders and all such other persons being hereinafter referred to collectively as the “ Releasees ” and individually as a “ Releasee ”), of and from all demands, actions, causes of action, suits, covenants, contracts, controversies, agreements, promises, sums of money, accounts, bills, reckonings, damages and any and all other claims, counterclaims, defenses, rights of set-off, demands and liabilities whatsoever of every name and nature, known or unknown, suspected or unsuspected, both at law and in equity, which Borrower, or any of its successors, assigns, or other legal representatives may now or hereafter own, hold, have or claim to have against the Releasees or any of them for, upon, or by reason of any circumstance, action, cause or thing whatsoever which arises at any time on or prior to the day and date of this Amendment, including, without limitation, for or on account of, or in relation to, or in any way in connection with the Loan and Security Agreement, or any of the other Loan Documents or transactions thereunder or related thereto. Borrower understands, acknowledges and agrees that the release set forth above may be pleaded as a full and complete defense and may be used as a basis for an injunction against any action, suit or other proceeding which may be instituted, prosecuted or attempted in breach of the provisions of such release. Borrower agrees that no fact, event, circumstance, evidence or transaction which could now be asserted or which may hereafter be discovered shall affect in any manner the final, absolute and unconditional nature of the release set forth above.

3

US-DOCS\85467854.2



(d)      No Reliance . The Borrower hereby acknowledges and confirms to Agent and the Lender that the Borrower is executing this Amendment on the basis of its own investigation and for its own reasons without reliance upon any agreement, representation, understanding or communication by or on behalf of any other Person.
(e)      Costs and Expenses . The Borrower agrees to pay to Agent on the Fifth Amendment Effective Date the out-of-pocket costs and expenses of Agent and the Lenders party hereto, and the fees and disbursements of counsel to Agent and the Lenders party hereto (including allocated costs of internal counsel), in connection with the negotiation, preparation, execution and delivery of this Amendment and any other documents to be delivered in connection herewith on the Fifth Amendment Effective Date or after such date.
(f)      Binding Effect . This Amendment binds and is for the benefit of the successors and permitted assigns of each party.
(g)      Governing Law. This Amendment, the Loan and Security Agreement and the other Loan Documents shall be governed by, and construed and enforced in accordance with, the laws of the State of California, excluding conflict of laws principles that would cause the application of laws of any other jurisdiction.
(h)      Complete Agreement; Amendments . This Amendment and the Loan Documents represent the entire agreement about this subject matter and supersede prior negotiations or agreements with respect to such subject matter. All prior agreements, understandings, representations, warranties, and negotiations between the parties about the subject matter of this Amendment and the Loan Documents merge into this Amendment and the Loan Documents.
(i)      Severability of Provisions. Each provision of this Amendment is severable from every other provision in determining the enforceability of any provision.
(j)      Counterparts . This Amendment may be executed in any number of counterparts and by different parties on separate counterparts, each of which, when executed and delivered, is an original, and all taken together, constitute one Amendment. Delivery of an executed counterpart of a signature page of this Amendment by facsimile, portable document format (.pdf) or other electronic transmission will be as effective as delivery of a manually executed counterpart hereof.
(k)      Loan Documents . This Amendment shall constitute a Loan Document.
[Balance of Page Intentionally Left Blank; Signature Pages Follow]



4

US-DOCS\85467854.2



IN WITNESS WHEREOF , the parties hereto have duly executed this Amendment, as of the date first above written.
BORROWER:
SORRENTO THERAPEUTICS, INC.
Signature:     /s/ Henry Ji, Ph.D.        
Print Name:    Henry Ji, Ph.D.
Title:        President & CEO

CONCORTIS BIOSYSTEMS, CORP.
Signature:     /s/ Henry Ji, Ph.D.        
Print Name:    Henry Ji, Ph.D.
Title:        President & CEO

ARK ANIMAL HEALTH, INC.
Signature:     /s/ Henry Ji, Ph.D.        
Print Name:    Henry Ji, Ph.D.
Title:        President & CEO

SORRENTO BIOLOGICS, INC.
Signature:     /s/ Henry Ji, Ph.D.        
Print Name:    Henry Ji, Ph.D.
Title:        President & CEO




[Signature Page to Fifth Amendment to Loan and Security Agreement (Sorrento/Hercules)]




TNK THERAPEUTICS, INC.
Signature:     /s/ Henry Ji, Ph.D.        
Print Name:    Henry Ji, Ph.D.
Title:        President & CEO

SCINTILLA PHARMACEUTICALS, INC.
Signature:     /s/ Henry Ji, Ph.D.        
Print Name:    Henry Ji, Ph.D.
Title:        President & CEO

LA CELL, INC.
Signature:     /s/ Henry Ji, Ph.D.        
Print Name:    Henry Ji, Ph.D.
Title:        Chief Executive Officer

SINIWEST HOLDING CORP.
Signature:     /s/ Henry Ji, Ph.D.        
Print Name:    Henry Ji, Ph.D.
Title:        President

LEVENA BIOPHARMA US INC.
Signature:     /s/ Henry Ji, Ph.D.        
Print Name:    Henry Ji, Ph.D.

[Signature Page to Fifth Amendment to Loan and Security Agreement (Sorrento/Hercules)]



Title:        President & CEO

BIOSERV CORPORATION
Signature:     /s/ Henry Ji, Ph.D.        
Print Name:    Henry Ji, Ph.D.
Title:        President

SCILEX PHARMACEUTICALS INC.
Signature:     /s/ Henry Ji, Ph.D.        
Print Name:    Henry Ji, Ph.D.
Title:        Chief Executive Officer


SNAN HOLDCO LLC
Signature:     /s/ Henry Ji, Ph.D.        
Print Name:    Henry Ji, Ph.D.
Title:        President




[Signature Page to Fifth Amendment to Loan and Security Agreement (Sorrento/Hercules)]



AGENT:
HERCULES CAPITAL, INC.
Signature:     /s/ Jennifer Choe        
Print Name:     Jennifer Choe        
Title:         Assistant General Counsel

LENDER:
HERCULES CAPITAL, INC.
Signature:     /s/ Jennifer Choe        
Print Name:     Jennifer Choe        
Title:         Assistant General Counsel


[Signature Page to Fifth Amendment to Loan and Security Agreement (Sorrento/Hercules)]
Exhibit 10.2
Execution Version

CONSENT AND SIXTH AMENDMENT TO LOAN AND SECURITY AGREEMENT
THIS CONSENT AND SIXTH AMENDMENT TO LOAN AND SECURITY AGREEMENT (this “ Amendment ”), dated as of April 27, 2017 (the “ Sixth Amendment Effective Date ”), is entered into by and among Sorrento Therapeutics, Inc., a Delaware corporation (“ Parent ”), Concortis Biosystems, Corp., a Delaware corporation, Ark Animal Health, Inc., a Delaware corporation, TNK Therapeutics, Inc., a Delaware corporation, Sorrento Biologics, Inc., a Delaware corporation, Scintilla Pharmaceuticals, Inc., a Delaware corporation, LA Cell, Inc., a Delaware corporation, SiniWest Holding Corp., a Delaware corporation, Levena Biopharma US, Inc., a Delaware corporation, BioServ Corporation (formerly known as Sorrento BioServices, Inc.), a Delaware corporation, Scilex Pharmaceuticals Inc., a Delaware corporation, SNAN Holdco LLC, a Delaware limited liability company and each of their Qualified Subsidiaries (together with “Parent” hereinafter collectively referred to as the “ Borrower ”), the several banks and other financial institutions or entities from time to time parties thereto as Lender, constituting the Required Lenders, and HERCULES CAPITAL, INC., formerly known as Hercules Technology Growth Capital, Inc., a Maryland corporation, in its capacity as administrative agent and collateral agent for itself and the Lender (in such capacity, together with its successors and assigns in such capacity, “ Agent ”).
The Borrower, the Lender and Agent are parties to a Loan and Security Agreement dated as of November 23, 2016 (as amended by that certain First Amendment to Loan and Security Agreement dated as of December 27, 2016, that certain Second Amendment to Loan and Security Agreement dated as of March 2, 2017, that certain Third Amendment to Loan and Security Agreement dated as of March 15, 2017, that certain Fourth Amendment to Loan and Security Agreement dated as of March 23, 2017, that certain Fifth Amendment to Loan and Security Agreement dated as of April 13, 2017, and as may be further amended, restated or modified from time to time, the “ Loan and Security Agreement ”). The Borrower has requested that the Lender agree to certain amendments to the Loan and Security Agreement. The Lender has agreed to such request, subject to the terms and conditions hereof.
Accordingly, the parties hereto agree as follows:
SECTION 1 Definitions; Interpretation.
(a)      Terms Defined in Loan and Security Agreement . All capitalized terms used in this Amendment (including in the recitals hereof) and not otherwise defined herein shall have the meanings assigned to them in the Loan and Security Agreement.
(b)      Interpretation . The rules of interpretation set forth in Section 1.1 of the Loan and Security Agreement shall be applicable to this Amendment and are incorporated herein by this reference.
SECTION 2      Amendment to the Loan and Security Agreement.
(a)      The Loan and Security Agreement shall be amended by replacing “$10,000,000” with “$5,000,000” in clause (g) of the definition of “Permitted Acquisition” therein.

1



(b)      References Within Loan and Security Agreement . Each reference in the Loan and Security Agreement to “this Agreement” and the words “hereof,” “herein,” “hereunder,” or words of like import, shall mean and be a reference to the Loan and Security Agreement as amended by this Amendment.
SECTION 3      Consent . Subject to (a) the payment and satisfaction in full of all indebtedness of Virttu Biologics Limited (“ Virttu ”) simultaneously with the closing of the Virttu Acquisition (as defined below) and receipt by Agent of payoff documents in form and substance satisfactory to Agent and (b) the other terms and conditions set forth herein, Agent and the Lenders hereby consent to Borrower entering into and consummating the transactions contemplated by that certain Share Purchase Agreement in the form attached hereto as Exhibit A (the “ Virttu Acquisition ”) , with the Virttu Acquisition deemed to be a “Permitted Acquisition” for all purposes under the Loan and Security Agreement. For the avoidance of doubt, the terms of the Loan and Security Agreement (including, without limitation, Section 7.13) with respect to Subsidiaries shall apply to Virttu upon consummation of the Virttu Acquisition.
SECTION 4      Conditions of Effectiveness. The effectiveness of Section 2 of this Amendment shall be subject to the satisfaction of each of the following conditions precedent:
(a)      Fees and Expenses . The Borrower shall have paid (i) all attorney fees and other costs and expenses then due in accordance with Section 6(e) , and (ii) all other fees, costs and expenses, if any, due and payable as of the Sixth Amendment Effective Date under the Loan and Security Agreement.
(b)      This Amendment . Agent shall have received this Amendment, executed by Agent, the Lender and the Borrower.
(c)      Representations and Warranties; No Default . On the Sixth Amendment Effective Date, after giving effect to the amendment of the Loan and Security Agreement contemplated hereby:
(i)      The representations and warranties contained in Section 5 shall be true and correct in all material respects on and as of the Sixth Amendment Effective Date as though made on and as of such date; and
(ii)      There exist no Events of Default or events that with the passage of time would result in an Event of Default.
SECTION 5      Representations and Warranties . To induce Agent and Lender to enter into this Amendment, the Borrower hereby confirms, as of the date hereof, (a) that the representations and warranties made by it in Section 5 of the Loan and Security Agreement and in the other Loan Documents are true and correct in all material respects; provided , however , that such materiality qualifier shall not be applicable to any representations and warranties that already are qualified or modified by materiality in the text thereof; (b) that there has not been and there does not exist a Material Adverse Effect; and (c) that the information included in the Perfection Certificate delivered to Agent on the Effective Date remains true and correct. For the purposes of this Section 5 , any representations and warranties which relate solely to an earlier date shall not be deemed confirmed

2
US-DOCS\86243905.4



and restated as of the date hereof (provided that such representations and warranties shall be true, correct and complete in all material respects as of such earlier date).
SECTION 6      Miscellaneous.
(a)      Loan Documents Otherwise Not Affected; Reaffirmation . Except as expressly amended pursuant hereto or referenced herein, the Loan and Security Agreement and the other Loan Documents shall remain unchanged and in full force and effect and are hereby ratified and confirmed in all respects. The Lender’s and Agent’s execution and delivery of, or acceptance of, this Amendment shall not be deemed to create a course of dealing or otherwise create any express or implied duty by any of them to provide any other or further amendments, consents or waivers in the future. The Borrower hereby reaffirms the grant of security under Section 3.1 of the Loan and Security Agreement and hereby reaffirms that such grant of security in the Collateral secures all Secured Obligations under the Loan and Security Agreement, including without limitation any Term Loans funded on or after the Sixth Amendment Effective Date, as of the date hereof.
(b)      Conditions . For purposes of determining compliance with the conditions specified in Section 4 , each Lender that has signed this Amendment shall be deemed to have consented to, approved or accepted or to be satisfied with, each document or other matter required thereunder to be consented to or approved by or acceptable or satisfactory to a Lender unless Agent shall have received notice from such Lender prior to the Sixth Amendment Effective Date specifying its objection thereto.
(c)      Release . In consideration of the agreements of Agent and each Lender contained herein and for other good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, Borrower, on behalf of itself and its successors, assigns, and other legal representatives, hereby fully, absolutely, unconditionally and irrevocably releases, remises and forever discharges Agent and each Lender, and its successors and assigns, and its present and former shareholders, affiliates, subsidiaries, divisions, predecessors, directors, officers, attorneys, employees, agents and other representatives (Agent, Lenders and all such other persons being hereinafter referred to collectively as the “ Releasees ” and individually as a “ Releasee ”), of and from all demands, actions, causes of action, suits, covenants, contracts, controversies, agreements, promises, sums of money, accounts, bills, reckonings, damages and any and all other claims, counterclaims, defenses, rights of set-off, demands and liabilities whatsoever of every name and nature, known or unknown, suspected or unsuspected, both at law and in equity, which Borrower, or any of its successors, assigns, or other legal representatives may now or hereafter own, hold, have or claim to have against the Releasees or any of them for, upon, or by reason of any circumstance, action, cause or thing whatsoever which arises at any time on or prior to the day and date of this Amendment, including, without limitation, for or on account of, or in relation to, or in any way in connection with the Loan and Security Agreement, or any of the other Loan Documents or transactions thereunder or related thereto. Borrower understands, acknowledges and agrees that the release set forth above may be pleaded as a full and complete defense and may be used as a basis for an injunction against any action, suit or other proceeding which may be instituted, prosecuted or attempted in breach of the provisions of such release. Borrower agrees that no fact, event, circumstance, evidence or transaction which could now be asserted or which may hereafter

3
US-DOCS\86243905.4



be discovered shall affect in any manner the final, absolute and unconditional nature of the release set forth above.
(d)      No Reliance . The Borrower hereby acknowledges and confirms to Agent and the Lender that the Borrower is executing this Amendment on the basis of its own investigation and for its own reasons without reliance upon any agreement, representation, understanding or communication by or on behalf of any other Person.
(e)      Costs and Expenses . The Borrower agrees to pay to Agent on the Sixth Amendment Effective Date the out-of-pocket costs and expenses of Agent and the Lenders party hereto, and the fees and disbursements of counsel to Agent and the Lenders party hereto (including allocated costs of internal counsel), in connection with the negotiation, preparation, execution and delivery of this Amendment and any other documents to be delivered in connection herewith on the Sixth Amendment Effective Date or after such date.
(f)      Binding Effect . This Amendment binds and is for the benefit of the successors and permitted assigns of each party.
(g)      Governing Law. This Amendment, the Loan and Security Agreement and the other Loan Documents shall be governed by, and construed and enforced in accordance with, the laws of the State of California, excluding conflict of laws principles that would cause the application of laws of any other jurisdiction.
(h)      Complete Agreement; Amendments . This Amendment and the Loan Documents represent the entire agreement about this subject matter and supersede prior negotiations or agreements with respect to such subject matter. All prior agreements, understandings, representations, warranties, and negotiations between the parties about the subject matter of this Amendment and the Loan Documents merge into this Amendment and the Loan Documents.
(i)      Severability of Provisions. Each provision of this Amendment is severable from every other provision in determining the enforceability of any provision.
(j)      Counterparts . This Amendment may be executed in any number of counterparts and by different parties on separate counterparts, each of which, when executed and delivered, is an original, and all taken together, constitute one Amendment. Delivery of an executed counterpart of a signature page of this Amendment by facsimile, portable document format (.pdf) or other electronic transmission will be as effective as delivery of a manually executed counterpart hereof.
(k)      Loan Documents . This Amendment shall constitute a Loan Document.
[Balance of Page Intentionally Left Blank; Signature Pages Follow]



4
US-DOCS\86243905.4



IN WITNESS WHEREOF , the parties hereto have duly executed this Amendment, as of the date first above written.
BORROWER:

SORRENTO THERAPEUTICS, INC.
Signature:     /s/ Henry Ji, Ph.D.        
Print Name:    Henry Ji, Ph.D.
Title:        President & CEO

CONCORTIS BIOSYSTEMS, CORP.
Signature:     /s/ Henry Ji, Ph.D.        
Print Name:    Henry Ji, Ph.D.
Title:        President & CEO

ARK ANIMAL HEALTH, INC.
Signature:     /s/ Henry Ji, Ph.D.        
Print Name:    Henry Ji, Ph.D.
Title:        President & CEO

SORRENTO BIOLOGICS, INC.
Signature:     /s/ Henry Ji, Ph.D.        
Print Name:    Henry Ji, Ph.D.
Title:        President & CEO



[Signature Page to Sixth Amendment to Loan and Security Agreement (Sorrento/Hercules)]




TNK THERAPEUTICS, INC.
Signature:     /s/ Henry Ji, Ph.D.        
Print Name:    Henry Ji, Ph.D.
Title:        President & CEO

SCINTILLA PHARMACEUTICALS, INC.
Signature:     /s/ Henry Ji, Ph.D.        
Print Name:    Henry Ji, Ph.D.
Title:        President & CEO

LA CELL, INC.
Signature:     /s/ Henry Ji, Ph.D.        
Print Name:    Henry Ji, Ph.D.
Title:        Chief Executive Officer

SINIWEST HOLDING CORP.
Signature:    _ /s/ Henry Ji, Ph.D.        
Print Name:    Henry Ji, Ph.D.
Title:        President

LEVENA BIOPHARMA US INC.
Signature:     /s/ Henry Ji, Ph.D.        
Print Name:    Henry Ji, Ph.D.

[Signature Page to Sixth Amendment to Loan and Security Agreement (Sorrento/Hercules)]



Title:        President & CEO

BIOSERV CORPORATION
Signature:     /s/ Henry Ji, Ph.D.        
Print Name:    Henry Ji, Ph.D.
Title:        President

SCILEX PHARMACEUTICALS INC.
Signature:     /s/ Henry Ji, Ph.D.        
Print Name:    Henry Ji, Ph.D.
Title:        Chief Executive Officer


SNAN HOLDCO LLC
Signature:     /s/ Henry Ji, Ph.D.        
Print Name:    Henry Ji, Ph.D.
Title:        President




[Signature Page to Sixth Amendment to Loan and Security Agreement (Sorrento/Hercules)]



AGENT:
HERCULES CAPITAL, INC.
Signature:     /s/ Jennifer Choe        
Print Name:     Jennifer Choe        
Title:         Assistant General Counsel

LENDER:
HERCULES CAPITAL, INC.
Signature:     /s/ Jennifer Choe        
Print Name:     Jennifer Choe        
Title:         Assistant General Counsel









[Signature Page to Sixth Amendment to Loan and Security Agreement (Sorrento/Hercules)]
Exhibit 10.4
*** Text Omitted and Filed Separately
Confidential Treatment Requested
Under 17 C.F.R. §§ 200.80(b)(4)
and 240.24b-2


CONTRIBUTION AGREEMENT
by and among
CELULARITY, INC.,
TNK THERAPEUTICS, INC.
and
SORRENTO THERAPEUTICS, INC.
Dated: June 12, 2017




TABLE OF CONTENTS

Page



ARTICLE I
DEFINITIONS; INTERPRETATION    1
Section 1.1
Definitions    1
Section 1.2
Interpretation and Rules of Construction    7
ARTICLE II
CONTRIBUTION    8
Section 2.1
Contribution    8
Section 2.2
Allocation    8
ARTICLE III
CLOSING; DELIVERIES    9
Section 3.1
Closing    9
Section 3.2
Consideration    9
Section 3.3
Celularity Closing Deliveries    9
Section 3.4
TNK Closing Deliveries    9
Section 3.5
Withholding    10
ARTICLE IV
REPRESENTATIONS AND WARRANTIES OF TNK    10
Section 4.1
Organization, Qualification and Organizational Power    10
Section 4.2
Authorization; Binding Effect    11
Section 4.3
Approvals and Consents    11
Section 4.4
Brokerage    11
Section 4.5
No Violation; Litigation or Regulatory Action    11

-i-

TABLE OF CONTENTS
(continued)
Page



Section 4.6
Investment Related Representations and Warranties    12
ARTICLE V
REPRESENTATIONS AND WARRANTIES OF SORRENTO    13
Section 5.1
Organization, Qualification and Organizational Power    13
Section 5.2
Authorization; Binding Effect    13
Section 5.3
Approvals and Consents    13
Section 5.4
Brokerage    14
Section 5.5
Litigation    14
ARTICLE VI
REPRESENTATIONS AND WARRANTIES OF CELULARITY    14
Section 6.1
Organization, Qualification and Organizational Power    14
Section 6.2
Authorization; Binding Effect    14
Section 6.3
Approvals and Consents    15
Section 6.4
Brokerage    15
Section 6.5
Capitalization    15
Section 6.6
No Violation; Litigation or Regulatory Action    15
Section 6.7
Directors    16
ARTICLE VII
COVENANTS    16
Section 7.1
Conduct of Business    16
Section 7.2
Access and Certain Information    17

-ii-

TABLE OF CONTENTS
(continued)
Page



Section 7.3
Public Announcements    17
Section 7.4
Transaction Expenses    17
Section 7.5
Further Assurances    17
Section 7.6
Cooperation and Exchange of Information    18
Section 7.7
“Market Stand-Off” Agreement    18
Section 7.8
Further Limitations on Disposition    19
Section 7.9
Financing    19
Section 7.10
Joint Program Agreement; Manufacturing Agreement    19
ARTICLE VIII
CONDITIONS TO THE CLOSING    20
Section 8.1
Conditions to Obligations of each of the Parties to Closing    20
Section 8.2
Conditions to Celularity’s Obligation    20
Section 8.3
Conditions to TNK’s and Sorrento’s Obligations    21
ARTICLE IX
TERMINATION    22
Section 9.1
Termination    22
Section 9.2
Effect of Termination    23
ARTICLE X
INDEMNIFICATION    23
Section 10.1
Indemnification    23
Section 10.2
Direct Claims    23

-iii-

TABLE OF CONTENTS
(continued)
Page



Section 10.3
Matters Involving Third Party Claims    24
Section 10.4
Limitations on Indemnification    25
ARTICLE XI
MISCELLANEOUS    27
Section 11.1
Confidentiality    27
Section 11.2
Consent to Amendments; Waiver    27
Section 11.3
Entire Agreement    27
Section 11.4
Successors and Assigns    27
Section 11.5
Governing Law; Consent to Jurisdiction; Venue; Waiver of Jury Trial    28
Section 11.6
Notices    28
Section 11.7
Schedules    29
Section 11.8
Counterparts    29
Section 11.9
Severability    29
Section 11.10
Time is of the Essence    30
Section 11.11
No Third-Party Beneficiaries    30
Section 11.12
No Strict Construction    30




-iv-



CONTRIBUTION AGREEMENT
This CONTRIBUTION AGREEMENT (this “ Agreement ”) is made as of June 12, 2017 (the “ Agreement Date ”), by and among Sorrento Therapeutics, Inc., a Delaware corporation (“ Sorrento ”), TNK Therapeutics, Inc., Delaware corporation and a majority owned subsidiary of Sorrento (the “ TNK ”), and Celularity, Inc., a Delaware corporation (“ Celularity ”).
WHEREAS, TNK, Sorrento, and Celularity intend to provide for the contribution by TNK of the Contribution (as defined below) on the terms and subject to the conditions set forth in this Agreement;
WHEREAS, the respective boards of directors of each of Celularity, TNK, and Sorrento have (a) determined that this Agreement and the Contemplated Transactions (as defined below) are in the best interests of their respective companies and respective stockholders, and (b) authorized, approved and declared advisable this Agreement and the Contemplated Transactions;
WHEREAS, the board of directors of TNK and Celularity have also recommended the adoption of this Agreement and approval of the principal terms of the Contemplated Transactions by its stockholders; and
WHEREAS, in furtherance of the foregoing, the Parties desire to enter into the Transaction Documents (as hereinafter defined).
NOW, THEREFORE, in consideration of the premises and the representations, warranties, covenants and agreements contained in this Agreement, and intending to be legally bound hereby, the Parties hereby agree as follows:
ARTICLE I
DEFINITIONS; INTERPRETATION
Section 1.1      Definitions . For the purposes of this Agreement, the following terms have the meanings set forth below:
Action ” means any action, audit, claim, complaint, demand, hearing, litigation, mediation, proceeding, citation, summons, subpoena or suit, whether civil, criminal, administrative or judicial commenced, brought, conducted or heard by or before, or otherwise involving, any Governmental Entity.
Affiliate ” means, as to any Person, any other Person who, directly or indirectly, controls, is controlled by, or is under common control with, such Person. For purposes of this definition, the term “ control ” of a Person means (a) the power to vote, directly or indirectly, fifty percent (50%) or more of the securities having ordinary voting power for the election of directors of such Person or (b) the possession, directly or indirectly, of the power to direct or cause the direction of the management and policies of such Person, whether through the ownership of voting securities, by Contract or otherwise, and the terms “ controlled ” and “ controlling ” have meanings correlative thereto. For purposes of this Agreement and the Transaction Documents, (i)





neither TNK nor Sorrento shall be deemed an Affiliate of Celularity, and (ii) Celularity shall not be deemed an Affiliate of TNK or Sorrento.
Antitrust Law ” means the Sherman Antitrust Act, as amended, the Clayton Antitrust Act, as amended, the HSR Act, the Federal Trade Commission Act, as amended, any foreign competition Law, and all other foreign or domestic Laws, decrees, administrative and judicial doctrines that are designed or intended to prohibit, restrict or regulate actions having the purpose or effect of monopolization, restraint of trade or lessening of competition.
Business Day ” means any day excluding Saturday, Sunday and any day which is a legal holiday under the Laws of the State of New Jersey or the State of California, or is a day on which banking institutions located in New Jersey or California are authorized or required by Law or other governmental action to close.
Celularity Common Stock ” means the common stock of Celularity, par value $0.0001.
Celularity Fundamental Representations ” means the representations and warranties of Celularity in Section 6.1 (Organization, Qualification and Organizational Power), Section 6.2 (Authorization; Binding Effect), Section 6.3 (Approvals and Consents), Section 6.4 (Brokerage) and Section 6.5 (Capitalization).
Celularity Material Adverse Effect ” means any event, change, development, effect, condition, occurrence or state of facts that is materially adverse to the operations, financial condition or value of, or obligations in respect of, Celularity or that prevents or materially delays the ability of Celularity to timely perform its obligations under this Agreement or any Transaction Document or to consummate the Contemplated Transactions; provided , that none of the following, either alone or in combination, shall be considered in determining whether there has been a “Celularity Material Adverse Effect” or a breach of a representation, warranty, covenant or agreement that is qualified by the term “Celularity Material Adverse Effect”: (a) events, circumstances, changes (including legal and regulatory changes) or effects that generally affect the industries or segments thereof in which Celularity operates, (b) general business, economic or political conditions (or changes therein) or events, circumstances, changes or effects affecting the securities markets generally, (c) changes arising from the consummation of the Contemplated Transactions, or the announcement of the execution of, or any action taken pursuant to or in furtherance of, this Agreement or at the request of or by TNK, Sorrento or any of their Affiliates or Representatives, or (d) any event, circumstance, change or effect caused by acts of terrorism or war (whether or not declared) occurring after the Agreement Date, and provided , further , that , any event, circumstance, change or condition in each case of clause (a) and (b), will be considered in determining whether there has been a “Celularity Material Adverse Effect” to the extent it materially and adversely disproportionately affects Celularity taken as a whole, relative to other businesses operating in the industries or segments thereof in which Celularity operates.
Celularity Shares ” means that number of shares of Celularity’s Series A Preferred Stock equal to 25.0% of Celularity’s outstanding shares of capital stock on the Closing Date, calculated on a fully-diluted basis after giving effect to (i) the issuance of such shares of

2



Celularity’s Series A Preferred Stock to TNK and assuming full exercise of all outstanding options, warrants and other rights to purchase capital stock of Celularity and full conversion of all securities convertible into capital stock of Celularity and including all shares reserved or authorized for issuance under Celularity’s equity or other plans, (ii) the issuance of Celularity
securities pursuant to the Merger Agreement, (iii) the issuance of Celularity securities pursuant to the Financing, and (iv) the issuance of any Celularity securities pursuant to the […***…] Acquisition; provided, however , that the foregoing shall not give effect to any contingent warrants issued to Investors in the Financing that are exercisable in connection with Celularity’s initial public offering in the event the initial public offering is not priced at an agreed upon multiple (the “ Warrants ”) as long as the equity ownership levels of all holders of Celularity securities (excluding in their capacity as Warrants holders) are diluted on a pro rata basis by such Warrants.
Celularity Transaction Expenses ” means, without duplication, (a) the aggregate third party legal, accounting, consulting, investment banking, financial advisory, brokerage and other third party fees and expenses incurred by or on behalf of Celularity in connection with this Agreement, the Transaction Documents and the Contemplated Transactions; and (b) one-half of all fees and expenses associated with obtaining necessary or appropriate consents of any Government Entities pursuant to the HSR Act or any other Antitrust Law in connection with the Contemplated Transactions.
Closing Celularity Share Price ” means the lowest price per share at which Celularity issues and sells shares of preferred stock in the Financing (as adjusted for any stock splits, reverse stock splits or similar events following the closing of the Financing).
Code ” means the Internal Revenue Code of 1986, as amended.
Contemplated Transactions ” means the transactions contemplated by this Agreement, including the Transaction Documents.
Contract ” means any agreement, contract, license, obligation or commitment to which a party is bound or to which its assets or properties are subject, whether oral or written, and any amendments and supplements thereto.
Financing ” means the issuance and sale Series A Preferred Stock in one or more capital-raising transactions (including the conversion of outstanding indebtedness other than the Sorrento Note), which results in gross cash proceeds to Celularity of not less than $[…***…].
Fundamental Representations ” means the TNK Fundamental Representations and the Celularity Fundamental Representations.
Governmental Entity ” means any nation or government, any foreign or domestic federal, state, county, municipal or other political instrumentality, regulatory or administrative body or subdivision thereof and any foreign or domestic entity or body exercising executive,

3



legislative, judicial, regulatory, administrative or taxing functions of or pertaining to government, including any court or tribunal.
Governmental Order ” means any order, writ, judgment, injunction, decree, stipulation, determination or award entered by or with any Governmental Entity.
HSR Act ” means the Hart-Scott-Rodino Antitrust Improvements Act of 1976, as amended, and the regulations promulgated thereunder.
IRS ” means the United States Internal Revenue Service.
Joint Program Agreement ” means that certain Joint Program Agreement to be entered into by and between TNK and Celularity.
Knowledge ” with respect to Sorrento or TNK means the knowledge of Dr. Henry Ji, and with respect to Celularity means the knowledge of Dr. Robert Hariri, in each case, including knowledge of those persons listed above that would be acquired by a reasonable person in discharging the job responsibilities of the position held by such individuals.
Law ” means any applicable federal, national, supranational, state, provincial, local or administrative statute, law, ordinance, regulation, rule, regulation, code, order, requirement or rule of law (including common law).
License and Transfer Agreement ” means that certain License and Transfer Agreement to be entered into by and between TNK and Celularity pursuant to which TNK will (i) license to Celularity the Licensed TNK Material and certain related technology, and (ii) effect a materials transfer to Celularity of the Licensed TNK Material, a transfer of certain specified related clinical data, if any, and a transfer of regulatory approvals, if any, in each case pursuant to the terms and conditions contained therein, which agreement will be in substantially the form of Exhibit A .
Licensed TNK Material shall have the meaning ascribed to such term in the License and Transfer Agreement.
Lien ” means any mortgage, pledge, lien, security interest or other encumbrance.
Losses ” means, with respect to any Person, the amount of any liabilities, costs, damages, deficiencies, Taxes, penalties, fines, settlements, judgments or other losses or expenses (including costs of investigation and defense and reasonable attorney and other professional advisor and consulting fees and expenses) incurred by such Person.
Manufacturing Agreement ” means that certain Manufacturing Agreement to be entered into by and between TNK and Celularity.
Merger Agreement ” means that certain Agreement and Plan of Merger, in substantially the form delivered to Sorrento and TNK on the date hereof, entered into or to be entered into by and between the Company, […***…] and […***…].

4



Party ” means each of Celularity, TNK, and Sorrento.
Permitted Lien ” means (a) Liens for Taxes not yet due and payable (excluding Liens arising under the Code), (b) Liens of carriers, warehousemen, mechanics, materialmen and repairmen incurred in the ordinary course of business consistent with past practice and not yet delinquent, and (c) in the case of real property, zoning, building, occupancy or other restrictions, variances, covenants, rights of way, encumbrances, easements and other minor irregularities in title, none of which, individually or in the aggregate, (i) interfere in any material respect with the present use of or occupancy of the affected parcel by the applicable Party, (ii) have more than an
immaterial effect on the value thereof or its use, or (iii) would impair the ability of such parcel to be sold for its present use.
Person ” means any individual, person, entity, general partnership, limited partnership, limited liability partnership, limited liability company, corporation, joint venture, trust, business trust, cooperative, association, foreign trust, foreign business organization or a Governmental Entity.
Representative ” means, with respect to a particular Person, any director, officer, employee, member, manager, agent, consultant, advisor or other representative of such Person, including legal counsel, accountants and financial advisors.
Services Agreement ” means that certain Services Agreement to be entered into by and between TNK and Celularity.
Sorrento Note ” means that certain Promissory Note, dated as of October 31, 2016, in the original amount of up to $10,000,000, executed by Celularity in favor of Sorrento, as the same may be amended from time to time.
Tax ” or “ Taxes ” means (a) any and all U.S. federal, state, local or non-U.S. taxes, charges, fees, imposts, levies or other assessments, including all net income, gross receipts, service, capital, sales, use, ad valorem, value added, transfer, franchise, profits, inventory, capital stock, license, net worth, withholding, payroll, employment, social security, unemployment, excise, severance, stamp, transfer and recording taxes, escheat, unclaimed property obligations, occupation, real or personal property and estimated taxes, customs duties, fees, assessments and charges of any kind whatsoever; and ( b ) all interest, penalties, fines, additions to tax or additional amounts imposed by the IRS or any other taxing authority in connection with any item described in clause (a) .
Tax Return ” means any return, declaration, report, claim for refund, or information return or statement relating to Taxes , including any schedule or attachment thereto, and including any amendment thereof, in each case, filed with a Governmental Entity . For the avoidance of doubt, the term “ Tax Return ” shall not include any Tax Return filed with respect to any combined, consolidated, or unitary group other than a group whose sole members are TNK and any subsidiaries thereof.

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TNK Fundamental Representations ” means the representations and warranties of TNK in Section 4.1 (Organization, Qualification and Organizational Power), Section 4.2 (Authorization; Binding Effect), Section 4.3 (Approvals and Consents), Section 4.4 (Brokerage) and Section 4.6 (Investment Related Representations and Warranties).
TNK Material Adverse Effect ” means any event, change, development, effect, condition, occurrence or state of facts that is materially adverse to the operations, financial condition or value of, or obligations in respect of, TNK or Sorrento, as applicable, or that prevents or materially delays the ability of TNK or Sorrento, as applicable, to timely perform its obligations under this Agreement or any Transaction Document or to consummate the Contemplated Transactions; provided , that none of the following, either alone or in combination, shall be considered in determining whether there has been a “TNK Material Adverse Effect” or a
breach of a representation, warranty, covenant or agreement that is qualified by the term “TNK Material Adverse Effect”: (a) events, circumstances, changes (including legal and regulatory changes) or effects that generally affect the industries or segments thereof in which TNK or Sorrento, as applicable, operates, (b) general business, economic or political conditions (or changes therein) or events, circumstances, changes or effects affecting the securities markets generally, (c) changes arising from the consummation of the Contemplated Transactions, or the announcement of the execution of, or any action taken pursuant to or in furtherance of, this Agreement or at the request of or by Celularity or any of its Affiliates or Representatives, or (d) any event, circumstance, change or effect caused by acts of terrorism or war (whether or not declared) occurring after the Agreement Date, and provided , further , that , any event, circumstance, change or condition in each case of clause (a) and (b), will be considered in determining whether there has been a “TNK Material Adverse Effect” to the extent it materially and adversely disproportionately affects TNK or Sorrento, as applicable, taken as a whole, relative to other businesses operating in the industries or segments thereof in which TNK or Sorrento, as applicable, operates.
TNK Transaction Expenses ” means, without duplication, (a) the aggregate third party legal, accounting, consulting, investment banking, financial advisory, brokerage and other third party fees and expenses incurred by or on behalf of TNK in connection with this Agreement, the Transaction Documents and the Contemplated Transactions; (b) any such fees and expenses incurred by Sorrento or its Affiliates to be paid for by TNK; and (c) one-half of all fees and expenses associated with obtaining necessary or appropriate consents of any Government Entities pursuant to the HSR Act or any other Antitrust Law in connection with the Contemplated Transactions.
Transaction Documents ” means the License and Transfer Agreement, the Services Agreement, the Manufacturing Agreement, the Joint Program Agreement, and any other agreement, certificate, instrument or other document to be executed and delivered pursuant hereto which is expressly identified as a Transaction Document.
Additional Defined Terms . Each of the following terms is defined in the Section set forth opposite such term:

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TERM
SECTION
Accounting Firm
2.2
Agreement
Preamble
Agreement Date
Preamble
Bankruptcy and Equity Exception
4.2
Celularity
Preamble
Celularity Indemnified Persons
10.1(a)
Closing
3.1
Closing Date
3.1
Contribution
2.1
Defaulting Party
9.2
Excluded Assets
2.1
 
 
[…***…] Acquisition
8.3(e)
Indemnified Person
10.2
Indemnifying Person
10.2
Initial Public Offering
7.7(a)
Investors
7.9
Notice of Claim
10.2
Objection Notice
10.2
Outside Date
9.1(b)
Securities Act
4.6(b)
Third Party Claim
10.3(a)
Third Party Notice
10.3(a)
Threshold
10.4(e)
TNK
Preamble
TNK Indemnified Persons
10.1(b)
Value
10.4(b)
Warrants
1.1

Section 1.2      Interpretation and Rules of Construction . Unless otherwise indicated to the contrary herein by the context or use thereof:
(a)      a capitalized term has the meaning assigned to it;
(b)      when a reference is made in this Agreement to an Article, Section, Exhibit or Schedule, such reference is to an Article or Section of, or an Exhibit or Schedule to, this Agreement;
(c)      the table of contents and headings for this Agreement are for reference purposes only and do not affect in any way the meaning or interpretation of this Agreement;
(d)      the words, “herein,” “hereto,” “hereof” and words of similar import refer to this Agreement as a whole and not to any particular Section or paragraph hereof;

* Confidential Treatment Requested
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(e)      references to “including” in this Agreement shall mean “including, without limitation,” whether or not so specified;
(f)      references in the singular or to “him,” “her,” “it,” “itself,” or other like references, and references in the plural or the feminine or masculine reference, as the case may be, shall also, when the context so requires, be deemed to include the plural or singular, or the masculine or feminine reference, as the case may be;
(g)      references to any statute shall be deemed to refer to such statute as amended from time to time and to any rules or regulations promulgated thereunder;
(h)      all accounting terms used herein and not expressly defined herein shall, except as otherwise noted, have the meanings assigned to such terms in accordance with United States generally accepted accounting principles as in effect from time to time.;
(i)     
(j)      all terms defined in this Agreement have the defined meanings when used in any certificate or other document made or delivered pursuant hereto, unless otherwise defined therein; and
(k)      all references to “$” will be references to United States Dollars, and with respect to any Contract, obligation, liability, claim or document that is contemplated by this Agreement, but denominated in currency other than United States Dollars, the amounts described in such Contract, obligation, liability, claim or document will be deemed to be converted into United States Dollars for purposes of this Agreement based on the noon buying rate in New York, as certified weekly by the Federal Reserve Bank of New York, in effect as of the applicable date of determination.
ARTICLE II     
CONTRIBUTION
Section 2.1      Contribution . Upon the terms and subject to the conditions set forth in this Agreement, at the Closing, TNK shall execute and deliver to Celularity the Transaction Documents (such execution and delivery, the “ Contribution ”). Notwithstanding the foregoing or any other provision of this Agreement, the Parties agree that TNK is not selling, transferring, or conveying to Celularity any assets, rights, or properties other than to the extent as may be expressly and specifically set forth in the License and Transfer Agreement (such excluded assets, rights, and properties being referred to collectively in this Agreement as the “ Excluded Assets ”). For clarification, except as expressly set forth in the License and Transfer Agreement, all of the assets, rights, or properties of Sorrento, including any antibodies and all rights therein are Excluded Assets. Furthermore, the Parties agree that, except as set forth in the License and Transfer Agreement, Celularity is not assuming and shall not be liable for, any obligations or liabilities of TNK or Sorrento.
Section 2.2      Allocation . Within 75 days after the Closing, Celularity shall deliver to TNK a copy of its proposed determination for allocation of the value of the Celularity Shares (and other items which for U.S. federal tax purposes constitutes consideration paid for the Contribution) among

* Confidential Treatment Requested
8



the Contribution set forth in this Agreement, which allocation shall be made in a manner consistent with Section 1060 of the Code and the regulations thereunder. If TNK does not object by written notice within sixty (60) days of receipt of the proposed allocation, then such allocation shall be final, binding and conclusive for Tax purposes. If TNK disagrees with the proposed allocation, TNK shall, within sixty (60) days of receipt of the proposed allocation, provide written notice to Celularity of such disagreement and Celularity and TNK shall negotiate in good faith to resolve such disagreement for up to an additional thirty (30) days. If the allocation is not mutually agreed upon within such period, the Parties shall submit such disagreement to a mutually agreed upon independent recognized valuation firm or independent recognized accounting firm of nationally recognized standing that is not then, and has not been in the previous one year period, serving as an independent auditor for either Celularity or TNK mutually selected by the Parties (the “ Accounting Firm ”) for a decision that shall be rendered in a timely manner in order to permit the timely filing of all applicable Tax Returns. The Accounting Firm’s decision shall be final and binding on all Parties. The fees and expenses of the Accounting Firm shall be borne equally by TNK and Celularity. To the extent the consideration payable pursuant to this Agreement is adjusted in accordance with the terms hereof, Celularity and TNK shall reflect such changes in the allocation. The Parties agree to file all Tax Returns (including IRS Form 8594 and, if required, supplemental Forms 8594, in accordance with the instructions to Form 8594) and any other forms, reports or information statements required to be filed pursuant to Section 1060 of the Code and the applicable regulations thereunder, and any similar or corresponding provision of state or local Tax law, in a manner that is consistent with such allocation and to refrain from taking any position inconsistent therewith.
ARTICLE III     
CLOSING; DELIVERIES
Section 3.1      Closing . Unless this Agreement shall have been validly terminated in accordance with Section 9.1 , the closing of the Contribution (the “ Closing ”) shall occur within two (2) Business Days following the day on which the last of the conditions specified in Sections 8.1 , 8.2 and 8.3 (other than those conditions that by their nature are to be satisfied at the Closing, but subject to the satisfaction or waiver of those conditions) are satisfied or waived in accordance with this Agreement, or on such other date as the Parties may otherwise agree. The day on which the Closing actually occurs is referred to herein as the “ Closing Date .”
Section 3.2      Consideration . At the Closing, upon the terms and subject to the conditions set forth in this Agreement, Celularity shall issue to TNK the Celularity Shares and, in connection therewith, shall deliver (electronically) to TNK a copy of the certificate(s) issued in the name of TNK and representing the Celularity Shares.
Section 3.3      Celularity Closing Deliveries . At the Closing, Celularity shall deliver or cause to be delivered to TNK:
(a)      duly executed counterparts of each of the Transaction Documents to which Celularity or its Affiliates is a party;

9



(b)      a certificate of a senior executive officer (or such other authorized Person, as applicable) of Celularity, in a form reasonably acceptable to TNK, certifying as of the Closing as to the fulfillment of the conditions set forth in Sections 8.3(a) and (b) hereof;
(c)      a certificate of a senior executive officer (or such other authorized Person, as applicable) of Celularity, in a form reasonably acceptable to TNK, attaching a copy of (i) the unanimous written consent of the board of directors of Celularity and (ii) the written consent of the stockholders of Celularity, in each case authorizing the Contemplated Transactions; and
(d)      a certificate, dated within five (5) days prior to the Closing, of the Secretary of State of Delaware establishing that Celularity is in existence and good standing under the Laws of the State of Delaware.
Section 3.4      TNK Closing Deliveries . At the Closing, TNK shall deliver or cause to be delivered to Celularity:
(a)      duly executed counterparts of each of the Transaction Documents to which TNK, Sorrento, or their respective Affiliates is a party;
(b)      a certificate of a senior executive officer (or such other authorized Person, as applicable) of TNK, in a form reasonably acceptable to Celularity, certifying as of the Closing as to the fulfillment of the conditions set forth in Sections 8.2(a) and (b) hereof;
(c)      a certificate of a senior executive officer (or such other authorized Person, as applicable), of TNK attaching a copy of (i) the resolutions duly adopted by the board of directors of TNK and (ii) the written consent of the stockholders of TNK, in each case authorizing the Contemplated Transactions;
(d)      a certificate of a senior executive officer (or such other authorized Person, as applicable) of Sorrento attaching a copy of the resolutions duly adopted by the board of directors of Sorrento authorizing the Contemplated Transactions;
(e)      a certificate, dated within five (5) days prior to the Closing, of the Secretary of State of Delaware establishing that TNK is in existence and good standing under the Laws of the State of Delaware; and
(f)      a properly executed statement, dated as of the Closing Date, in accordance with Treasury Regulation Section 1.1445-2(b)(2) and in a form reasonably acceptable to Celularity, certifying that TNK is not a foreign person for purposes of Code Section 1445.
Section 3.5      Withholding . Celularity shall be entitled to withhold and deduct from any consideration payable or otherwise deliverable pursuant to this Agreement such amounts as Celularity is required to deduct and withhold therefrom under the Code or any provision of state, local, or non-U.S. Tax Law, as and if applicable. Celularity shall timely deduct, withhold, and pay over any deducted or withheld amounts to the appropriate Governmental Entity and any such

10



amounts that are so deducted or withheld and timely paid over to the appropriate Governmental Entity shall be treated for all purposes of this Agreement as having been paid to TNK.
ARTICLE IV     
REPRESENTATIONS AND WARRANTIES OF TNK
As a material inducement to Celularity entering into this Agreement and consummating the Contemplated Transactions, except as set forth in any disclosure schedules hereto, TNK hereby represents and warrants to Celularity, as of the Agreement Date and the Closing Date, as follows:
Section 4.1      Organization, Qualification and Organizational Power . TNK is a corporation duly incorporated, validly existing, and in good standing under the Laws of the State of Delaware and has all necessary corporate power and authority to enter into this Agreement and the Transaction Documents to which it is a party, to carry out its obligations hereunder and thereunder, and to consummate the Contemplated Transactions. TNK is duly licensed or qualified to do business and is in good standing in each jurisdiction in which the properties owned or leased by it and the operation of TNK’s business as currently conducted by it makes such licensing or qualification necessary, except to the extent that the failure to be so licensed, qualified or in good standing would not have a TNK Material Adverse Effect. TNK has made available to Celularity or its counsel correct and complete copies of the certificate of incorporation and bylaws, including all amendments thereto, of TNK.
Section 4.2      Authorization; Binding Effect . The execution and delivery by TNK of this Agreement and the Transaction Documents to which it is a party, the performance by it of its obligations hereunder and thereunder, and the consummation by it of the Contemplated Transactions have been duly authorized by all requisite action on the part of TNK. This Agreement has been, and upon their execution the Transaction Documents shall have been, duly executed and delivered by TNK, and (assuming due authorization, execution and delivery by the other Parties) this Agreement constitutes, and upon their execution the Transaction Documents shall constitute, legal, valid and binding obligations of TNK which are enforceable against TNK in accordance with their respective terms, except as such enforceability may be limited by (i) applicable insolvency, bankruptcy, reorganization, moratorium or other similar Laws affecting creditors’ rights generally, and (ii) applicable equitable principles (whether considered in a proceeding at Law or in equity) (the “ Bankruptcy and Equity Exception ”).
Section 4.3      Approvals and Consents.
(a)      Except as may be required by the HSR Act and any other applicable Antitrust Laws, the execution, delivery and performance of this Agreement and each Transaction Document by TNK does not and will not require any consent, approval, authorization or other order or declaration of, action by, filing with, notification to or permit from, any Governmental Entity.
(b)      Assuming the making and obtaining of all filings, notifications, consents, approvals, authorizations and other actions referred to in Section 4.3(a) , and except as set forth on Schedule 4.3(b) or as may result from any facts or circumstances relating solely to Celularity, the

11



execution, delivery and performance of this Agreement and the Transaction Documents by TNK does not and will not (i) violate, conflict with or result in the breach of the organizational documents of TNK or (ii) conflict with or violate any Law or Governmental Order applicable to TNK, except, in the case of clause (ii), as would not have a TNK Material Adverse Effect.
Section 4.4      Brokerage . TNK does not have any liability or obligation to pay any fees or commissions to any broker, finder, or agent with respect to the Contemplated Transactions for which Celularity or any of its Affiliates could become liable or obligated.
Section 4.5      No Violation; Litigation or Regulatory Action . Except as set forth on Schedule 4.5 :
(a)      TNK is not now, and during the last three years has not been, subject to or bound by any Governmental Order challenging the Contemplated Transactions or against or affecting all or any portion of the Licensed TNK Material.
(b)      There are not now, nor since TNK’s incorporation has there been, any Actions pending or, to the Knowledge of TNK, threatened in writing against or involving TNK, challenging the Contemplated Transactions or against or affecting all or any portion of the Licensed TNK Material.
(c)      There is not now, nor in the last three years has there been, any Action against TNK by, nor has TNK received any notice or charge from, any Governmental Entity alleging any material violation of applicable Law, and to the Knowledge of TNK, no such notice, charge or Action is threatened.
Section 4.6      Investment Related Representations and Warranties .
(a)      The Celularity Shares will be acquired for investment for TNK’s own account, not as a nominee or agent, and not with a view to the resale or distribution of any part thereof, and TNK has no present intention of selling, granting any participation in, or otherwise distributing the same. By executing this Agreement, TNK further represents that TNK does not have any contract, undertaking, agreement or arrangement with any Person to sell, transfer or grant participations to such Person with respect to any of the Celularity Shares.
(b)      TNK is an “accredited investor” within the meaning of Rule 501(a) promulgated under the Securities Act of 1933, as amended (the “ Securities Act ”), as presently in effect. TNK acknowledges that it has the capacity to protect its own interests in connection therewith, can bear the economic risk of its investment and has such knowledge and experience in financial or business matters that it is capable of evaluating the merits and risks of the investment in the Celularity Shares. TNK also represents it has not been organized for the purpose of acquiring the Celularity Shares.
(c)      TNK acknowledges and understands that (i) the Celularity Shares issued pursuant to this Agreement will be issued in a transaction exempt from registration under the Securities Act by reason of Section 4(a)(2) thereof and/or Regulation D promulgated under the

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Securities Act and may not be re-offered or resold other than in conformity with the registration requirements of the Securities Act and such other applicable rules and regulations or pursuant to an exemption therefrom, (ii) until the Celularity Shares have become transferable pursuant to an exemption from such registration otherwise required thereunder, the Celularity Shares shall be characterized as “restricted securities” under the federal securities laws inasmuch as they are being acquired from Celularity in a transaction not involving a public offering, (iii) under such laws and applicable regulations, such securities may be resold without registration under the Securities Act only in certain limited circumstances, and (iv) the certificates evidencing the Celularity Shares will bear the following legend reflecting restrictions on the transfer of such securities, in addition to any legend required by applicable U.S. state securities laws:
“THE SHARES REPRESENTED BY THIS CERTIFICATE HAVE BEEN ACQUIRED FOR INVESTMENT AND NOT WITH A VIEW TO, OR IN CONNECTION WITH, THE SALE OF DISTRIBUTION THEREOF. THESE SECURITIES HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED. THEY MAY NOT BE SOLD, OFFERED FOR SALE, PLEDGED OR HYPOTHECATED IN THE ABSENCE OF AN EFFECTIVE REGISTRATION STATEMENT AS TO THE SECURITIES UNDER SAID ACT OR AN OPINION OF COUNSEL SATISFACTORY TO THE COMPANY THAT SUCH REGISTRATION IS NOT REQUIRED.”
(d)      TNK represents that it is familiar with Rule 144 under the Securities Act, as presently in effect, and understands the resale limitations imposed thereby and by the Securities Act. TNK understands and acknowledges that the acquisition of the Celularity Shares involves an extremely high degree of risk and may result in a complete loss of its investment in the Celularity Shares. TNK understands that the Celularity Shares have not been and will not be registered under the Securities Act and have not been and will not be registered or qualified in any state in which they are offered, and thus TNK will not be able to resell or otherwise transfer its Celularity Shares unless they are registered under the Securities Act and registered or qualified under applicable state securities laws, or an exemption from such registration or qualification is available.
ARTICLE V     
REPRESENTATIONS AND WARRANTIES OF SORRENTO
As a material inducement to Celularity entering into this Agreement and consummating the Contemplated Transactions, except as set forth on any disclosure schedule hereto, Sorrento hereby represents and warrants to Celularity, as of the Agreement Date and the Closing Date, as follows:
Section 5.1      Organization, Qualification and Organizational Power . Sorrento is a corporation duly incorporated, validly existing, and in good standing under the Laws of the State of Delaware and has all necessary corporate power and authority to enter into this Agreement and the Transaction Documents to which it is a party, to carry out its obligations hereunder and thereunder, and to consummate the Contemplated Transactions. Sorrento is duly licensed or qualified to do business and is in good standing in each jurisdiction in which the properties owned or leased by it or the operation of its business as currently conducted by it makes such licensing or qualification

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necessary, except to the extent that the failure to be so licensed, qualified or in good standing would not have a TNK Material Adverse Effect. Correct and complete copies of the certificate of incorporation and bylaws, including all amendments thereto, of Sorrento, are available publicly through the Securities and Exchange Commission’s EDGAR system.
Section 5.2      Authorization; Binding Effect . The execution and delivery by Sorrento of this Agreement and the Transaction Documents to which it is a party, the performance by it of its obligations hereunder and thereunder, and the consummation by it of the Contemplated Transactions have been duly authorized by all requisite action on the part of Sorrento. This Agreement has been, and upon their execution the Transaction Documents shall have been, duly executed and delivered by Sorrento, and (assuming due authorization, execution and delivery by the other Parties) this Agreement constitutes, and upon their execution the Transaction Documents shall constitute, legal, valid and binding obligations of Sorrento which are enforceable against Sorrento in accordance with their respective terms, subject to the Bankruptcy and Equity Exception.
Section 5.3      Approvals and Consents.
(a)      Except as may be required by the HSR Act and any other applicable Antitrust Laws, the execution, delivery and performance of this Agreement and each Transaction Document by Sorrento does not and will not require any consent, approval, authorization or other order or declaration of, action by, filing with, notification to or permit from, any Governmental Entity.
(b)      Assuming the making and obtaining of all filings, notifications, consents, approvals, authorizations and other actions referred to in Section 5.3(a) , and except as set forth on Schedule 5.3(b) or as may result from any facts or circumstances relating solely to Celularity, the execution, delivery and performance of this Agreement and the Transaction Documents by Sorrento does not and will not (i) violate, conflict with or result in the breach of the organizational documents of Sorrento or (ii) conflict with or violate any Law or Governmental Order applicable to Sorrento, except, in the case of clause (ii), as would not have a TNK Material Adverse Effect.
Section 5.4      Brokerage . Sorrento does not have any liability or obligation to pay any fees or commissions to any broker, finder, or agent with respect to the Contemplated Transactions for which Celularity or any of its Affiliates could become liable or obligated.
Section 5.5      Litigation . Except as set forth on Schedule 5.5 :
(a)      Sorrento is not now subject to or bound by any Governmental Order challenging the Contemplated Transactions.
(b)      There is not now any Action pending or, to the Knowledge of Sorrento, threatened in writing against Sorrento challenging the Contemplated Transactions.
ARTICLE VI     
REPRESENTATIONS AND WARRANTIES OF CELULARITY

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As a material inducement to TNK and Sorrento entering into this Agreement and consummating the Contemplated Transactions, except as set forth on any disclosure schedule hereto, Celularity hereby represents and warrants to TNK and Sorrento, as of the Agreement Date and the Closing Date , as follows:
Section 6.1      Organization, Qualification and Organizational Power . Celularity is a corporation duly organized, validly existing and in good standing under the Laws of the State of Delaware, and has all necessary corporate power and authority to enter into this Agreement and the Transaction Documents to which it is a party, to carry out its obligations hereunder and thereunder, and to consummate the Contemplated Transactions. Celularity is duly licensed or qualified to do business and is in good standing in each jurisdiction in which the properties owned or leased by it and the operation of its business as currently conducted by it makes such licensing or qualification necessary, except to the extent that the failure to be so licensed, qualified or in good standing would not have a Celularity Material Adverse Effect. Celularity has made available to TNK or its counsel correct and complete copies of the certificate of incorporation and bylaws, including all amendments thereto, of Celularity.
Section 6.2      Authorization; Binding Effect . The execution and delivery by Celularity of this Agreement and the Transaction Documents to which it is a party, the performance by Celularity of its obligations hereunder and thereunder and the consummation of the Contemplated Transactions have been duly authorized by all requisite action on the part of Celularity. This Agreement has been, and upon its execution the Transaction Documents shall have been, duly executed and delivered by Celularity, and (assuming due authorization, execution and delivery by the other Parties) this Agreement constitutes, and upon their execution the Transaction Documents shall constitute, legal, valid and binding obligations of Celularity which are enforceable against Celularity in accordance with their respective terms, subject to the Bankruptcy and Equity Exception.
Section 6.3      Approvals and Consents.
(a)      Except as may be required by the HSR Act and any other applicable Antitrust Laws, the execution, delivery and performance of this Agreement and each Transaction Document by Celularity does not and will not require any consent, approval, authorization or other order or declaration of, action by, filing with, notification to or permit from, any Governmental Entity.
(b)      Assuming the making and obtaining of all filings, notifications, consents, approvals, authorizations and other actions referred to in Section 6.3(a) or as may result from any facts or circumstances relating solely to TNK and/or Sorrento, the execution, delivery and performance of this Agreement and the Transaction Documents by Celularity does not and will not (i) violate, conflict with or result in the breach of the organizational documents of Celularity or (ii) conflict with or violate any Law or Governmental Order applicable to Celularity, except, in the case of clause (ii), as would not have a Celularity Material Adverse Effect.
Section 6.4      Brokerage . Celularity does not have any liability or obligation to pay any fees or commissions to any broker, finder, or agent with respect to the Contemplated Transactions for which Sorrento, TNK or any of their respective Affiliates could become liable or obligated.

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Section 6.5      Capitalization.
(a)      Schedule 6.5(a) sets forth a complete and accurate list of all authorized, issued and outstanding capital stock of Celularity, the holders thereof, the number and class of shares of capital stock of Celularity held by each such holder, and the percentage interest in Celularity held by each such holder, as of the Agreement Date. All capital stock of Celularity has been duly authorized and is validly issued, fully paid and non-assessable and such capital stock has not been issued or transferred in violation of any Laws. Schedule 6.5(a) sets forth a complete and accurate list of all outstanding preemptive rights, options, warrants, conversion privileges and rights (including but not limited to rights of first refusal or similar rights), orally or in writing, to purchase or acquire any securities from Celularity, and any securities convertible into or exchangeable or exercisable for shares of capital stock of Celularity.
(b)      Upon consummation of the Contemplated Transactions and the issuance to TNK of the Celularity Shares, TNK shall own all of the Celularity Shares, free and clear of all Liens, except for restrictions on transfer under applicable securities laws or Contracts to which TNK is a party.
Section 6.6      No Violation; Litigation or Regulatory Action.
(a)      Celularity is not now, and since its incorporation, has not been, subject to or bound by any Governmental Order challenging the Contemplated Transactions or against or affecting all or any portion of Celularity’s business or assets.
(b)      There are not now, nor since the incorporation of Celularity has there been, any Actions pending or, to the Knowledge of Celularity, threatened in writing against or involving Celularity, challenging the Contemplated Transactions or against or affecting all or any portion of Celularity’s business or assets.
(c)      There is not now, nor since the incorporation of Celularity has there been, any Action against or involving Celularity by, nor has Celularity received any notice or charge from, any Governmental Entity alleging any material violation of applicable Law, and to the Knowledge of Celularity, no such notice or charge or Action is threatened.
Section 6.7      Directors. Each of Henry Ji, Ph.D., Jaisim Shah and David Deming has been appointed to, and is currently a member of, Celularity’s board of directors.

ARTICLE VII     
COVENANTS
Section 7.1      Conduct of Business.
(a)      Except as may be otherwise contemplated by this Agreement or any Transaction Document, or as required by Law, from the Agreement Date and until the Closing, without the prior written consent of Celularity (such consent not to be unreasonably withheld

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conditioned or delayed), TNK shall (a) conduct its business with respect to the Licensed TNK Materials in the ordinary course of business and consistent with past practice, and (b) use commercially reasonable best efforts to maintain and preserve intact its current business organization and operations and to preserve the rights, goodwill and relationships of its employees, suppliers, regulators and other relationships with the business of TNK with respect to the Licensed TNK Materials. In connection with the foregoing, except as may be otherwise contemplated by this Agreement or the Transaction Documents, or as required by Law, from the Agreement Date and prior to the Closing, TNK shall: (i) pay the debts, taxes and other obligations with respect to the Licensed TNK Materials when due; (ii) maintain the assets included in the Licensed TNK Materials in the same condition as they were on the Agreement Date, subject to reasonable wear and tear; (iii) defend and protect the Licensed TNK Materials from infringement or usurpation; and (iv) comply in all material respects with all Laws applicable to the conduct of the business of TNK related to the Licensed TNK Materials. In addition, except as may be otherwise contemplated by this Agreement or the Transaction Documents, or as required by Law, from the Agreement Date and until the Closing, TNK shall not (1) sell, transfer, or otherwise dispose of all or any portion of the Licensed TNK Materials; (2) license all or any portion of the Licensed TNK Materials in any manner which would nullify or otherwise limit the scope of the license to be issued to Celularity pursuant to the License and Transfer Agreement; (3) suffer to exist, cause or permit any Lien upon any portion of the Licensed TNK Materials (other than Permitted Liens); or (4) agree or commit to take any of the actions described in clauses (1) through (3) of this Section 7.1(a) .
(b)      Except as may be otherwise contemplated by this Agreement or any Transaction Document, or as required by Law, from the Agreement Date and until the Closing, without the prior written consent of TNK (such consent not to be unreasonably withheld conditioned or delayed), Celularity shall (a) conduct its business in the ordinary course of business and consistent with past practice, and (b) use commercially reasonable best efforts to maintain and preserve intact its current business organization and operations and to preserve the rights, goodwill and relationships of its employees, suppliers, regulators and other relationships with the business of Celularity. In connection with the foregoing, except as may be otherwise contemplated by this Agreement or the Transaction Documents, or as required by Law, from the Agreement Date and prior to the Closing, Celularity shall: (i) pay its debts, taxes and other obligations when due; (ii) maintain its assets in the same condition as they were on the Agreement Date, subject to reasonable wear and tear; (iii) defend and protect its intellectual property from infringement or usurpation; and (iv) comply in all material respects with all Laws applicable to the conduct of the business of Celularity. In addition, except as may be otherwise contemplated by this Agreement, the Transaction Documents or the Merger Agreement, or as required by Law, from the Agreement Date and until the Closing, Celularity shall not (1) sell, transfer, or otherwise dispose of all or any portion of its assets, except in the ordinary course of business; (2) license all or any portion of its assets; (3) suffer to exist, cause or permit any Lien upon any portion of its assets (other than Permitted Liens); or (4) agree or commit to take any of the actions described in clauses (1) through (3) of this Section 7.1(b) .
Section 7.2      Access and Certain Information . From the Agreement Date through the Closing, TNK shall provide Celularity, and Celularity shall provide TNK, with reasonable access to such information as Celularity or TNK, as applicable, may from time to time reasonably request with respect to the Contemplated Transactions.

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Section 7.3      Public Announcements . From and after the Agreement Date, the Parties shall not, and shall cause their respective Affiliates and Representatives to not, make any press release or public statement with respect to this Agreement or the Contemplated Transactions without the prior written consent of the other Parties, except as may be required by Law or the rules of the stock exchange upon which a Party’s securities are listed, quoted or traded; provided , that the Party proposing to issue a public announcement or communication to satisfy a legal requirement or rule of the stock exchange upon which a Party’s securities are listed, quoted or traded shall provide the other Parties with the text of such announcement or communication reasonably prior to its issuance and consider in good faith comments provided by the other Parties.
Section 7.4      Transaction Expenses . Except as otherwise expressly set forth herein, whether or not the Closing is consummated, all TNK Transaction Expenses shall be paid by TNK and all Celularity Transaction Expenses shall be paid by Celularity.
Section 7.5      Further Assurances . The Parties agree (without being obligated to make any payment to any third party (other than payments to Governmental Entities in respect of any governmental permits necessitated by the Contemplated Transactions)) to use their commercially reasonable best efforts to take, or cause to be taken, all actions and to do, or cause to be done, all things necessary, proper or advisable to consummate and make effective as promptly as practicable the Contemplated Transactions. The Parties agree (a) to furnish upon request to each other such further information, (b) to execute and deliver to each other such other documents, and (c) to do such other acts and things, all as the other Parties may reasonably request for the purpose of carrying out the intent of this Agreement.
Section 7.6      Cooperation and Exchange of Information . Each Party shall, and shall cause its Affiliates to, provide to the other Parties such cooperation, documentation and information relating to this Agreement as either of them reasonably may request in connection with the filing of any Tax Return, the determination of liabilities for Taxes, or the conducting any Tax audits or similar proceedings. Each Party shall make its employees reasonably available on a mutually convenient basis at its cost to provide an explanation of any documents or information so provided.
Section 7.7      “Market Stand-Off” Agreement.
(a)      TNK hereby agrees that it will not, directly or indirectly, without the prior written consent of Celularity and the managing underwriter for the Initial Public Offering (as defined below), during the period commencing on the date of the final prospectus relating to Celularity’s first underwritten public offering of its equity securities pursuant to an effective registration statement filed under the Securities Act (the “ Initial Public Offering ”) and ending on the date specified by Celularity and the managing underwriter for the Initial Public Offering (such period not to exceed one hundred eighty (180) days) (i) lend, offer, pledge, sell, contract to sell, sell any option or contract to purchase, purchase any option or contract to sell, grant any option, right or warrant to purchase, or otherwise transfer or dispose of, directly or indirectly, any shares of Celularity Common Stock or any securities convertible into or exercisable or exchangeable for shares of Celularity Common Stock, held by TNK immediately prior to the effectiveness of the registration statement for such offering, excluding transfers by TNK to Sorrento, or (ii) enter into any swap or other arrangement that transfers to another, in whole or in part, any of the economic consequences

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of ownership of the Celularity Common Stock, whether any such transaction described in clause (i) or (ii) above is to be settled by delivery of Celularity Common Stock or such other securities, in cash or otherwise. The foregoing provisions of this Section 7.7 shall not apply to the sale of any shares to an underwriter pursuant to an underwriting agreement, and shall only be applicable to TNK if all officers and directors and greater than five percent (5%) stockholders of Celularity are similarly bound and shall only apply to the Initial Public Offering. The underwriters in connection with the Initial Public Offering are intended third party beneficiaries of this Section 7.7 and shall have the right, power and authority to enforce the provisions hereof as though they were a party hereto; further, TNK hereby agrees to enter into written agreement with such underwriters containing terms substantially equivalent to the terms of this Section 7.7 , and TNK hereby agrees that such underwriters shall be entitled to require TNK to enter into such written agreement. If any record or beneficial owner of 10% or more of Celularity Common Stock is granted an early release from the restrictions described herein during the Initial Public Offering market stand-off or lock-up period with respect to any Celularity Common Stock, then TNK shall also be granted an early release from its obligations hereunder on a pro rata basis with all other record or beneficial holders of similarly restricted securities of the Company based on the maximum percentage of shares held by any such record or beneficial holder being released from such holder’s market standoff obligation or lock-up agreement.
(b)      In order to enforce the limitations of this Section 7.7 , subject to last sentence of Section 7.7(a) , Celularity may impose stop-transfer instructions with respect to the Celularity Shares until the end of the applicable market stand-off period.
Section 7.8      Further Limitations on Disposition. Without in any way limiting the representations of TNK set forth in this Agreement, TNK hereby agrees, prior to the earlier to occur of (a) an Initial Public Offering or (b) the that later of (i) the one-year anniversary of the Closing Date or (ii) the final resolution of any indemnity claim brought by Celularity in accordance with Article X of this Agreement, not to make any dispositions of all or any portion of the Celularity Shares, other than to an Affiliate of TNK, unless and until the transferee has agreed for the benefit of Celularity in writing (in form and substance reasonably acceptable to Celularity) to be bound by the terms and conditions of this Agreement (including the indemnification obligations set forth in Article X ), and
(a)      There is then in effect a registration statement under the Securities Act covering such proposed disposition and such disposition is made in accordance with such registration statement; or
(b)      (i) TNK shall have notified Celularity of the proposed disposition and shall have furnished Celularity with a reasonably detailed statement of the circumstances surrounding the proposed disposition, and (ii) if reasonably requested by Celularity, TNK shall have furnished Celularity with an opinion of counsel reasonably satisfactory to Celularity that such disposition will not require registration of such shares under the Securities Act. It is agreed that Celularity will not require opinions of counsel for transactions made pursuant to Rule 144 except in unusual circumstances.

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Section 7.9      Financing . Celularity shall use its commercially reasonable best efforts to cause the Financing to be completed immediately prior to the Closing in order to cause the condition set forth in Section 8.1(e) to be satisfied. Celularity shall provide TNK with the opportunity to review and comment on all documents or agreements (the “ Financing Documents ”) to be executed by investors in connection with the Financing (the “ Investors ”). Subject to Celularity’s compliance with the prior sentence and provided that the Financing Documents do not impose any obligations on TNK that are not imposed on all other Investors, or adversely affect TNK in a manner that is disproportionate to the treatment of any other Investor, TNK shall execute and deliver to Celularity counterpart signature pages to such Financing Documents (other than the Series A Preferred Stock Purchase Agreement) on or before the closing of the Financing agreeing to be bound by the terms and conditions thereof.
Section 7.10      Joint Program Agreement; Manufacturing Agreement . The Parties agree to use commercially reasonable efforts to enter into on the Closing Date or promptly thereafter as practicable, (a) a Joint Program Agreement regarding the development, co-marketing, and co-promotion of CD38 CAR-T for multiple myeloma, which revenue will be shared 50% by Celularity and 50% by Sorrento and TNK; (b) a Manufacturing Agreement pursuant to which Celularity will agree to manufacture cell therapy products with respect to certain of the assets subject to the Contribution, and (c) a Services Agreement pursuant to which TNK will agree to provide certain services to Celularity, in each case on terms and conditions acceptable to the applicable parties.
ARTICLE VIII     
CONDITIONS TO THE CLOSING
Section 8.1      Conditions to Obligations of each of the Parties to Closing . The respective obligations of each of the Parties to consummate the Contemplated Transactions are subject to the satisfaction at or prior to the Closing Date of the following conditions, any of which may be waived in writing by mutual agreement by the Parties (unless such waiver would be a violation of applicable Law):
(a)      No Order . No Governmental Entity of competent jurisdiction shall have enacted, issued, promulgated, enforced or entered any non-appealable, final and effective Law, injunction or other order which has the effect of making the Contemplated Transactions illegal or otherwise prohibited.
(b)      Antitrust Requirements . All requirements under Antitrust Laws reasonably determined to apply prior to the Closing in connection with the Contemplated Transactions shall have been satisfied. Without limitation of the foregoing, the filings of Celularity and TNK pursuant to the HSR Act, if any, shall have been made and the applicable waiting period and any extensions thereof shall have expired or been terminated.
(c)      Governmental Entity Consents . The Parties shall have received all required consents, authorizations, orders and approvals from Governmental Entities, and no such consent, authorization, order or approval shall have been revoked.

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(d)      Merger Closing . The closing of the merger contemplated by the Merger Agreement shall have been consummated, all conditions to closing set forth in the Merger Agreement (other than those to be performed on the closing date of the transactions contemplated thereby) shall have been performed or complied with (or waived by the applicable party) and Celularity shall have delivered to TNK and Sorrento reasonable evidence of the foregoing.
(e)      Financing . The Financing shall have been consummated and Celularity shall have delivered to TNK and Sorrento (i) reasonable evidence that the Financing has been consummated prior to the Closing, and (ii) copies of the Financing Documents and all other documents prepared or executed by the investors in connection therewith.
Section 8.2      Conditions to Celularity’s Obligation . Celularity’s obligation to consummate the Contemplated Transactions at the Closing is subject to the satisfaction (or waiver by Celularity in its sole discretion, it being understood that no such waiver shall waive any rights or remedies otherwise available to Celularity unless explicitly waived) at or prior to the Closing Date of the following conditions precedent:
(a)      Representations and Warranties . The representations and warranties of TNK and Sorrento contained in Article IV and Article V that are qualified by materiality shall be true and correct on and as of the Agreement Date and the Closing Date as if made on and as of such dates (other than representations and warranties which address matters only as of a certain date which shall be true and correct as of such certain date) and each of the representations and warranties that are not so qualified shall be true and correct in all material respects on and as of the Agreement Date and the Closing Date as if made on and as of such dates (other than representations and warranties which address matters only as of a certain date which shall be true and correct in all material respects as of such certain date).
(b)      Compliance with Covenants . TNK, Sorrento, and their respective Affiliates shall have performed or complied in all material respects with all of the covenants and agreements required to be performed and complied with by them under this Agreement on or prior to the Closing.
(c)      Document Deliveries . Celularity shall have received from each of TNK and Sorrento the documents that each of TNK and Sorrento is required to deliver or cause to be delivered pursuant to Section 3.4 .
(d)      No TNK Material Adverse Effect . From the Agreement Date, there shall not have occurred any TNK Material Adverse Effect, nor shall any event or events have occurred that, individually or in the aggregate, with or without notice or lapse of time (or both) would reasonably be expected to result in a TNK Material Adverse Effect.
Section 8.3      Conditions to TNK’s and Sorrento’s Obligations . TNK’s and Sorrento’s obligation to consummate the Contemplated Transactions at the Closing is subject to the satisfaction (or waiver by each of TNK and Sorrento in its sole discretion, it being understood that no such waiver shall waive any rights or remedies otherwise available to TNK or Sorrento, respectively, unless explicitly waived) at or prior to the Closing Date of the following conditions precedent:

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(a)      Representations and Warranties . The representations and warranties of Celularity contained in Article VI that are qualified by materiality shall be true and correct on and as of the Agreement Date and the Closing Date as if made on and as of such dates (other than representations and warranties which address matters only as of a certain date which shall be true and correct as of such date) and each of the representations and warranties that are not so qualified shall be true and correct in all material respects on and as of the Agreement Date and the Closing Date as if made on and as of such dates (other than representations and warranties which address matters only as of a certain date which shall be true and correct as of such date).
(b)      Compliance with Covenants . Celularity and its Affiliates shall have performed or complied in all material respects with all of the covenants and agreements required to be performed and complied with by them under this Agreement on or prior to the Closing.
(c)      Document Deliveries and Consideration . TNK shall have received from Celularity the documents that Celularity is required to deliver or cause to be delivered pursuant to Section 3.3 .
(d)      No Celularity Material Adverse Effect . From the Agreement Date, there shall not have occurred any Celularity Material Adverse Effect, nor shall any event or events have occurred that, individually or in the aggregate, with or without notice or lapse of time (or both) would reasonably be expected to result in a Celularity Material Adverse Effect.
(e)     

(f)      […***…]. TNK shall have received from Celularity evidence, reasonably satisfactory to TNK, that the transactions contemplated by that certain Membership Interest Purchase Agreement, dated April 24, 2017, by and among […***…], Celularity and Robert Hariri and […***…], as maybe amended or restated from time to time, have closed (the “[…***…] Acquisition ”)].
ARTICLE IX     
TERMINATION
Section 9.1      Termination . This Agreement may be terminated at any time prior to the Closing:
(a)      by the mutual written consent of TNK and Celularity;
(b)      by Celularity if, by the date that is 120 days from the Agreement Date (the “ Outside Date ”), the conditions set forth in Sections 8.1 and 8.2 shall not have been satisfied, complied with or performed (unless such failure of satisfaction, compliance or performance is the direct result of any action or failure to act on the part of Celularity and such action or failure constitutes a material breach of this Agreement);

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(c)      by TNK, if, by the Outside Date, the conditions set forth in Sections 8.1 and 8.3 shall not have been satisfied, complied with or performed (unless such failure of satisfaction, compliance or performance is the result, directly or indirectly, of any action or failure to act on the part of TNK and such action or failure constitutes a material breach of this Agreement);
(d)      by Celularity, if TNK and/or Sorrento has materially breached or failed to comply with its warranties, representations or obligations under this Agreement such that the conditions set forth in Section 8.2(a) or Section 8.2(b) would not reasonably be expected to be satisfied, and such breach or failure to comply shall not have been cured within a period of thirty (30) calendar days after Celularity shall have given written notice to TNK of such breach or failure to comply;
(e)      by TNK, if Celularity has materially breached or failed to comply with its warranties, representations or obligations under this Agreement such that the conditions set forth in Section 8.3(a) or Section 8.3(b) would not reasonably be expected to be satisfied, and such breach or failure to comply shall not have been cured within a period of thirty (30) calendar days after TNK shall have given written notice to Celularity of such breach or failure to comply; or
(f)      by either Celularity or TNK if any Governmental Entity having jurisdiction over a Party shall have issued an order, decree or ruling or taken any other action permanently enjoining, restraining or otherwise prohibiting the Contemplated Transactions and such order, decree, ruling or other action shall have become final and nonappealable; provided , that the right to terminate this Agreement pursuant to this Section 9.1(f) shall not be available to any Party whose breach of any provisions of this Agreement has been the cause of, resulted in, or contributed to, such order, decree, ruling or other action.
(g)     

Section 9.2      Effect of Termination . Termination of this Agreement pursuant to this Article IX shall terminate all obligations of the Parties, except for the obligations under this Section 9.2 , Section 11.1 , Section 11.5 or Section 11.6 hereof, provided , that nothing in this Section 9.2 shall relieve or limit the liability hereunder of any Party (the “ Defaulting Party ”) to another Party on account of fraud or in connection with a willful and material breach of this Agreement by the Defaulting Party. For purposes of this Agreement, a “willful and material breach” shall mean a material breach that is the consequence of an act undertaken by the breaching party with the actual knowledge that the taking of such action would cause a breach.
ARTICLE X     
INDEMNIFICATION
Section 10.1      Indemnification.
(a)      Subject to the limitations set forth in Section 10.4 , from and after the Closing Date, TNK shall indemnify, defend and hold harmless Celularity and its Affiliates and all of their

* Confidential Treatment Requested
23



respective officers, managers, directors, shareholders, members, Affiliates, employees and agents (the “ Celularity Indemnified Persons ”) from and against any Losses actually suffered or incurred by such Celularity Indemnified Persons arising out of or resulting from (i) any breach by TNK or Sorrento of any representation or warranty of TNK or Sorrento contained in Article IV or Article V of this Agreement, in any certificate delivered by TNK or Sorrento pursuant to the terms and conditions hereof or the License and Transfer Agreement, (ii) any failure by TNK or Sorrento or any of their respective Affiliates or Representatives to perform or comply with any covenant of TNK or Sorrento or any of their respective Affiliates or Representatives in this Agreement, (iii) any claim arising out of or resulting from the Excluded Assets; and (iv) any unpaid TNK Transaction Expenses as of the Closing.
(b)      Subject to the limitations set forth in Section 10.4 , from and after the Closing Date, Celularity shall indemnify, defend and hold harmless TNK, its Affiliates and all of their respective officers, managers, directors, shareholders, members, Affiliates, employees and agents (the “ TNK Indemnified Persons ”) from and against any Losses actually suffered or incurred by such TNK Indemnified Persons arising out of or resulting from (i) any breach by Celularity of any representation or warranty of Celularity contained in Article VI of this Agreement, in any certificate delivered by Celularity pursuant to this Agreement or the License and Transfer Agreement, (ii) any failure by Celularity or any of its Affiliates or Representatives to perform or comply with any covenant of Celularity in this Agreement, and (iii) any unpaid Celularity Transaction Expenses as of the Closing.
Section 10.2      Direct Claims . If any Celularity Indemnified Person or TNK Indemnified Person (each an “ Indemnified Person ”) shall claim indemnification hereunder for any claim (other than a third party claim) for which indemnification is provided in Section 10.1 above, Celularity (on behalf of a Celularity Indemnified Person) or TNK (on behalf of a TNK Indemnified Person) shall promptly, give written notice (a “ Notice of Claim ”) to TNK or Celularity, as applicable (each, an “ Indemnifying Person ”), setting forth the basis for such claim or demand and the nature and estimated amount of the claim, all in reasonable detail; provided , that no delay in providing such Notice of Claim will affect an Indemnified Person’s rights hereunder except (and only then to the extent that) the Indemnifying Person is materially and adversely prejudiced thereby. If an Indemnifying Person disputes any claim set forth in the Notice of Claim, it shall deliver to such Indemnified Person that has given the Notice of Claim written notice indicating its dispute of such Notice of Claim (an “ Objection Notice ”) within thirty (30) days after the date the Notice of Claim is given. Following the receipt of an Objection Notice, the Indemnified Person and the Indemnifying Person shall attempt in good faith to agree upon the rights of the respective parties with respect to each of such claims in the Notice of Claim. If the Indemnified Person and the Indemnifying Person should so agree, a memorandum setting forth such agreement shall be prepared and signed by TNK and Celularity and the Indemnifying Person shall promptly pay such Losses as are set forth in such memorandum. If the Indemnified Person and the Indemnifying Person are unable to resolve such dispute after good faith discussions within thirty (30) days (as may be extended in writing by TNK and Celularity) following delivery of an Objection Notice, such dispute shall be resolved by a court of competent jurisdiction in accordance with Section 11.5 hereof.

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Section 10.3      Matters Involving Third Party Claims.
(a)      If an Indemnified Person shall claim indemnification hereunder arising from any claim or demand of a third party for which indemnification is provided in Section 10.1 above (a “ Third Party Claim ”), the Indemnified Person shall promptly give written notice (a “ Third Party Notice ”) to the Indemnifying Person, of the basis for such claim or demand, setting forth the nature of the claim or demand in reasonable detail. Such Third Party Notice shall contain or be accompanied by such other material information as the Indemnified Party shall have concerning the Third Party Claim.
(b)      The Indemnifying Person , upon notice to the Indemnified Person within fifteen (15) days after receiving a Third Party Notice , shall have the right to assume and control the defense of such Third Party Claim with counsel of its own choosing, at its sole discretion, for which the Indemnifying Person is obligated to indemnify pursuant to this Article  X at its own cost and through counsel of its choosing, subject to the limitations contained in this Article X ; provided , however , that the Indemnifying Person shall not have the right to assume and control such defense: (i) if such Third Party Claim involves criminal or fraudulent allegations, (ii) if outside counsel advises the Indemnified Person that there are conflicts of interest between the Indemnifying Person and the Indemnified Person with respect to the Third Party Claim that cannot be waived, and/or (iii) if such Third Party Claim seeks relief other than monetary damages. If the Indemnifying Person elects to assume the defense of a Third Party Claim, the Indemnified Person shall at all times have the right to fully participate in such defense at its own expense directly or through counsel. If no notice of intent to defend is timely given by the Indemnifying Person, the Indemnified Person shall, at the expense of the Indemnifying Person, undertake (with counsel selected by the Indemnified Person and reasonably acceptable to the Indemnifying Person) the defense of such claim, liability or expense, and shall have the right to compromise or settle such claim, liability or expense with the consent of the Indemnifying Person, which consent shall not be unreasonably withheld, conditioned or delayed
(c)      If the Indemnifying Person elects to assume the defense of a Third Party Claim, the Indemnifying Person shall have the right to compromise and settle in good faith all indemnifiable matters related to the applicable Third Party Claim which are susceptible to being settled, except to the extent that (i) such settlement would involve relief other than monetary
damages, (ii) such settlement does not include an unconditional release of the Indemnified Person from all liability in respect of such claim or (iii) such settlement would reasonably be expected to have a material adverse effect on the Indemnified Person. If the Indemnifying Person elects to assume the defense of a Third Party Claim, the Indemnifying Person shall from time to time apprise the Indemnified Person of the status of the claim, liability or expense and any resulting Action (including any enforcement Action) and shall furnish the Indemnified Person with such documents and information filed or delivered in connection with such claim, liability or expense as the Indemnified Person may reasonably request. If the Indemnifying Person elects to assume the defense of a Third Party Claim, the Indemnified Person will cooperate and make available to the Indemnifying Party (and its Representatives) its employees on reasonable notice and during business hours, and furnish such books and records in its possession or under its control as may be reasonably

25



necessary or useful in connection with such defense; provided , that (A) the provision of or access to any records and information or employees will be subject to appropriate confidentiality undertakings and, if applicable, execution of customary release letters in favor of the auditors as requested in connection with the sharing of work papers, and (B) nothing in this subsection will require any party to disclose information that is subject to the attorney-client privilege.
Section 10.4      Limitations on Indemnification.
(a)      The representations and warranties set forth in Articles IV , V , and VI will survive the Closing until the […***…] anniversary of the Closing, except that all Fundamental Representations will survive the Closing until the expiration of the applicable statute of limitations. Notwithstanding the foregoing, any indemnification claims asserted in accordance with this Article  X prior to the expiration date of the applicable statute of limitations shall not thereafter be barred and such claims shall survive until finally resolved.
(b)      With respect to any claim for indemnification by a Celularity Indemnified Person, TNK shall have the option, in its sole discretion, to satisfy any Losses for which such Celularity Indemnified Person is entitled to indemnification hereunder by paying the aggregate dollar amount of the Losses, or any portion thereof, due and owing pursuant to the terms of this Article X in cash and/or surrendering to Celularity such number of Celularity Shares issued to TNK as is equal to: (A) the aggregate dollar amount of the Losses, or any portion thereof, due and owing pursuant to the terms of this Article X , divided by (B) the Value of one Celularity Share. For purposes of this Article X , “ Value ” shall mean the greater of (1) the Closing Celularity Share Price (only if the Financing has occurred), and (2) the value of one Celularity Share based on the fair market value of Celularity, calculated as of the date that such payment is to be made to a Celularity Indemnified Person for such Loss, with such determination of fair market value to be made in good faith by mutual written agreement of Celularity and TNK; provided , however , that if Celularity and TNK cannot mutually agree on the fair market value of Celularity, then Celularity and TNK shall mutually agree in writing upon an independent third party valuation firm, which shall be instructed to make a determination of the fair market value of Celularity as if all of Celularity’s equity were being sold in a single transaction, assuming a willing buyer and a willing seller, to the highest bidder pursuant to a competitive auction process where the objective is to obtain the highest price reasonably obtainable for Celularity as a whole (without liquidity or marketability or minority discounts). The determination by the independent third party valuation firm will be made within ten (10) Business Days after its retention and will
be final and binding upon the parties; provided , however , that in no event shall the Value of one Celularity Share based on the fair market value of Celularity as determined by the independent valuation firm be lower than the Closing Celularity Share Price. The fees, costs and expenses of the independent third party valuation firm will be borne by TNK.
(c)      After the Closing, the indemnification provided in this Article X (including all limitations contained herein) shall be the sole and exclusive remedy for all matters relating to this Agreement, and for the breach of any representation, warranty, covenant or agreement contained herein or in any certificate delivered hereunder; provided , however , that (i) the foregoing shall not apply in the case of claims based solely upon the fraud, fraudulent misrepresentation or fraudulent

26



misconduct of a Party hereto, and (ii) no Party shall be prohibited from seeking any equitable relief available to it pursuant to this Agreement with respect to any failure by another Party to perform any covenant of it contained in this Agreement.
(d)      Notwithstanding anything contained herein to the contrary, the limitations on indemnification in this Section 10.4 shall not apply in the case of fraud, fraudulent misrepresentation or fraudulent misconduct by any Party.
(e)      Notwithstanding anything to the contrary set forth in this Section 10.4 , except in the case of fraud, fraudulent misrepresentation or fraudulent misconduct by TNK, Sorrento or any of their respective Affiliates or their Representatives or breach of any TNK Fundamental Representation, the TNK Indemnifying Persons shall have no liability with respect to any claim for indemnification pursuant to Section 10.1(a)(i) unless and until the aggregate amount of all Losses for which TNK would, but for this clause, be liable pursuant to Section 10.1(a)(i) , exceed on a cumulative basis $[…***…] (the “ Threshold ”), in which case TNK Indemnifying Persons shall be liable for the amount of all Losses, regardless of the Threshold.
(f)      Except in the case of fraud, fraudulent misrepresentation or fraudulent misconduct by TNK, Sorrento or any of their respective Affiliates or Representatives or breach of any TNK Fundamental Representation, under no circumstance shall the aggregate amount of all Losses for which TNK Indemnified Persons are liable for indemnification pursuant to Section 10.1(a)(i) exceed $5,000,000. Except in the case of fraud, fraudulent misrepresentation or fraudulent misconduct by TNK, Sorrento or any of their respective Affiliates or Representatives, under no circumstance shall the aggregate amount of all Losses for which TNK Indemnified Persons are liable for indemnification pursuant to Section 10.1(a)(i) with respect to breaches of TNK Fundamental Representations exceed $10,000,000.
(g)      Except in the case of fraud, fraudulent misrepresentation or fraudulent misconduct by Celularity, its Affiliates or Representatives or breach of any Celularity Fundamental Representation, under no circumstance shall the aggregate amount of all Losses for which Celularity Indemnified Persons are liable for indemnification pursuant to Section 10.1(b)(i) exceed $5,000,000. Except in the case of fraud, fraudulent misrepresentation or fraudulent misconduct by Celularity or any of its Affiliates or Representatives, under no circumstance shall the aggregate amount of all Losses for which Celularity Indemnified Persons are liable for indemnification pursuant to Section 10.1(b)(i) with respect to breaches of Celularity Fundamental Representations exceed $10,000,000.
(h)     
ARTICLE XI     
MISCELLANEOUS
Section 11.1      Confidentiality . Except for disclosures expressly permitted pursuant to Section 7.3 , each Party agrees that it will not, and will cause its Representatives not to, use any information obtained pursuant to Section 7.2 (as well as any other information obtained in connection with the entering into of this Agreement) for any purpose unrelated to the Contemplated

27



Transactions. Subject to the requirements of applicable Law, each Party will keep confidential, and will cause its Representatives to keep confidential, all information and documents obtained pursuant to Section 7.2 (as well as any other information obtained in connection with the entering into of this Agreement) unless such information (a) was already known to such Party on a non-confidential basis and other than as a result of a breach of a confidentiality obligation by any Person, as evidenced by such Party’s written records, (b) becomes available to such Party from other sources not known by such party to be bound by a confidentiality obligation and who learn such information other than as a result of a breach of a confidentiality obligation by any Person, (c) is disclosed with the prior written approval of the Party to which such information pertains or (d) is or becomes readily ascertainable from published information or trade sources other than as a result of the wrongful act of any Person. In the event that this Agreement is terminated or the Contemplated Transactions shall otherwise fail to be consummated, each Party shall promptly cause all copies of documents or extracts thereof containing information and data as to another Party to be destroyed (in which case such Party shall furnish a certificate of destruction to the other Parties) or returned to the Party which furnished the same, except as required by applicable Law, regulation or document retention policies. No investigation pursuant to this Section 11.1 or information provided or received by any Party pursuant to this Agreement will affect any of the representations or warranties of the Parties contained in this Agreement or the conditions hereunder to the obligations of the Parties.
Section 11.2      Consent to Amendments; Waiver . This Agreement may be amended or modified, in each case upon the approval, in writing, executed by Celularity and TNK. Each of Celularity and TNK, as applicable, may: (a) extend the time for the performance of any of the obligations or other acts of the other; (b) waive any inaccuracies in the representations and warranties of the other contained herein or in any document delivered by the other pursuant hereto or (c) waive compliance with any of the agreements of the other or conditions to such other’s obligations contained herein. Any such extension or waiver will be valid only if set forth in an instrument in writing signed by the party to be bound thereby.
Section 11.3      Entire Agreement . This Agreement, including the Schedules attached hereto, and the other agreements referred to herein constitute the entire agreement among the Parties with respect to the matters covered hereby and supersede all previous written, oral or implied understandings among them with respect to such matters.
Section 11.4      Successors and Assigns . Except as otherwise expressly provided in this Agreement, all covenants and agreements set forth in this Agreement by or on behalf of the Parties shall bind and inure to the benefit of the respective successors and permitted assigns of the Parties, whether so expressed or not, except that neither this Agreement nor any of the rights, interests or obligations hereunder may be assigned by any Party without the prior written consent of the other Parties.
Section 11.5      Governing Law; Consent to Jurisdiction; Venue; Waiver of Jury Trial . THIS AGREEMENT WILL BE GOVERNED BY AND CONSTRUED IN ACCORDANCE WITH THE DOMESTIC LAWS OF THE STATE OF DELAWARE FOR CONTRACTS ENTERED INTO AND TO BE PERFORMED IN SUCH STATE WITHOUT GIVING EFFECT TO ANY CHOICE OR CONFLICT OF LAW PROVISION OR RULE (WHETHER OF THE STATE OF DELAWARE

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OR ANY OTHER JURISDICTION) THAT WOULD CAUSE THE APPLICATION OF THE LAWS OF ANY JURISDICTION OTHER THAN THE STATE OF DELAWARE. EACH PARTY HERETO HEREBY SUBMITS TO THE EXCLUSIVE JURISDICTION OF THE UNITED STATES DISTRICT COURT FOR THE SOUTHERN DISTRICT OF NEW YORK AND OF ANY NEW YORK STATE COURT SITTING IN NEW YORK, NEW YORK FOR PURPOSES OF ALL LEGAL PROCEEDINGS ARISING OUT OF OR RELATING TO THE CONTEMPLATED TRANSACTIONS AND AGREES THAT PROCESS SHALL BE SERVED UPON SUCH PARTY IN THE MANNER SET FORTH IN SECTION 11.6 , AND THAT SERVICE IN SUCH MANNER SHALL CONSTITUTE VALID AND SUFFICIENT SERVICE OF PROCESS. EACH PARTY HERETO IRREVOCABLY WAIVES, TO THE FULLEST EXTENT PERMITTED BY LAW, ANY OBJECTION WHICH IT MAY NOW OR HEREAFTER HAVE TO THE LAYING OF THE VENUE OF ANY SUCH PROCEEDING BROUGHT IN SUCH A COURT AND ANY CLAIM THAT ANY SUCH PROCEEDING BROUGHT IN SUCH A COURT HAS BEEN BROUGHT IN AN INCONVENIENT FORUM. EACH PARTY HERETO HEREBY IRREVOCABLY WAIVES ANY AND ALL RIGHT TO TRIAL BY JURY IN ANY LEGAL PROCEEDING ARISING OUT OF OR RELATING TO THE CONTEMPLATED TRANSACTIONS.
Section 11.6      Notices . All notices and other communications given or made pursuant hereto shall be in writing and shall be deemed to have been duly given or made (a) as of the date delivered, if delivered personally, (b) on the date the delivering party receives confirmation, if delivered by facsimile or electronic transmission, (c) three (3) Business Days after being mailed by registered or certified mail (postage prepaid, return receipt requested) or (d) one (1) Business Day after being sent by overnight courier (providing proof of delivery), to the Parties at the following addresses (or at such other address for a Party as shall be specified in a notice given in accordance with this Section 11.6 ):
If to TNK or Sorrento, to:
TNK Therapeutics, Inc.
4955 Directors Place
San Diego, CA 92121
Facsimile:    (858) 210-3759
Attention:    Henry Ji, Ph.D.

    Chief Executive Officer
Sorrento Therapeutics, Inc.
4955 Directors Place
San Diego, CA 92121
Facsimile:    (858) 210-3759
Attention:    Henry Ji, Ph.D.

    Chief Executive Officer
with copies, which shall not constitute notice to TNK or Sorrento, to:
TNK Therapeutics, Inc.
4955 Directors Place

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Facsimile: (858)210-3759
Attention: Legal Department
and
Paul Hastings LLP
4747 Executive Drive
San Diego, CA 92121
Facsimile: (858) 458-3122
Attention: Jeffrey T. Hartlin, Esq.
If to Celularity, to:
Celularity, Inc.
7 Powderhorn Drive
Warren, New Jersey 07059
Attention: Dr. Robert Hariri, Chief Executive Officer
Telephone No.: (732) 564-3503
Email Address: robert.hariri@celularity.com
with a copy, which shall not constitute notice to Celularity, to:
Jones Day
12265 El Camino Real, Suite 200
San Diego, California 92130
Facsimile: (858) 314-1150
Attention: John E. Wehrli, Esq.; Kenneth D. Polin, Esq.
Section 11.7      Schedules . The Schedules to this Agreement constitute a part of this Agreement and are incorporated into this Agreement for all purposes as if fully set forth herein. The disclosure of any item or matter in any Schedule hereto shall not be taken as an indication of the materiality thereof or the level of materiality that is applicable to any representation or warranty set forth herein. Without limiting the foregoing, no such reference to or disclosure of a possible breach or violation of any Contract, Law or Governmental Order shall be construed as an admission or indication that a breach or violation exists or has actually occurred.
Section 11.8      Counterparts . This Agreement may be executed in counterparts, all of which taken together shall constitute one agreement. For purposes of this Agreement, signatures delivered by facsimile or by email in the portable document format (PDF) or any other electronic format shall be accepted and binding as original signatures.
Section 11.9      Severability . Should any provision of this Agreement or the application thereof to any Person or circumstance be held invalid or unenforceable to any extent: (a) such provision shall be ineffective to the extent, and only to the extent, of such unenforceability or prohibition and shall be enforced to the greatest extent permitted by Law, (b) such unenforceability or prohibition in any jurisdiction shall not invalidate or render unenforceable such provision as

30



applied (i) to other Persons or circumstances or (ii) in any other jurisdiction, and (c) such unenforceability or prohibition shall not affect or invalidate any other provision of this Agreement.
Section 11.10      Time is of the Essence . Each of the Parties hereby expressly acknowledges and agrees that time is of the essence for each and every provision of this Agreement.
Section 11.11      No Third-Party Beneficiaries . Except as otherwise expressly provided in this Agreement, no Person which is not a party shall have any right or obligation pursuant to this Agreement.
Section 11.12      No Strict Construction . Each of the Parties acknowledges that this Agreement has been prepared jointly by the Parties, and shall not be strictly construed against any Party.
[SIGNATURE PAGE FOLLOWS]


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IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written above.
TNK THERAPEUTICS, INC.
By:
/s/ Henry Ji, Ph.D.    
Name: Henry Ji, Ph.D.
Title: Chief Executive Officer
SORRENTO THERAPEUTICS, INC.
By:
/s/ Henry Ji, Ph.D.    
Name: Henry Ji, Ph.D.
Title: President & CEO
CELULARITY, INC.
By:
/s/ Robert Hariri, Ph.D.    
Name: Robert Hariri, Ph.D.
Title: Chief Executive Officer

[SIGNATURE PAGE TO CONTRIBUTION AGREEMENT]
Exhibit 10.5

AMENDMENT NO. 1 TO
PROMISSORY NOTE
THIS AMENDMENT NO. 1 TO PROMISSORY NOTE (this “ Amendment ”) is made as of June 12, 2017 by and among Celularity, Inc., a Delaware corporation (the “ Borrower ”) and Sorrento Therapeutics, Inc., a Delaware corporation (“ Lender ”).
RECITALS
A. Borrower has previously issued to Lender that certain Promissory Note, dated as of October 31, 2016, in the original principal amount of up to $10,000,000 (the “ Note ”).
B.      As of immediately prior to the effectiveness of this Amendment, Lender has loaned to Borrower an aggregate of $7,000,000 pursuant to the Note.
C.      Pursuant to Section 16 of the Note, the Note may be amended upon the written consent of the Borrower and Lender.
D.      Borrower and Lender now desire to amend Section 4 of the Note.
E.      Concurrent with the execution and delivery of this Amendment, Borrower, Lender and TNK Therapeutics, Inc., are entering into that certain Contribution Agreement dated as of even date hereof (the “ Contribution Agreement ”).
NOW THEREFORE , in consideration of the foregoing recitals and the mutual agreements contained herein, Borrower and Lender, intending to be legally bound, hereby agree as follows:
1. Definitions; Construction . Capitalized terms not otherwise defined herein shall have the meanings set forth in the Note. References in the Note to “this Note” (and indirect references such as “hereunder”, “hereby”, “herein” and “hereof”) shall be deemed to be references to the Note as amended hereby.
2.      Amendment to Section 1 of the Note . Section 1 of the Note is hereby amended and restated to read as follows:
Principal and Interest . For value received, as herein provided, Celularity Inc., a Delaware corporation (“ Borrower ”) promises to pay to Sorrento Therapeutics, Inc., a Delaware corporation (“ Lender ”), the principal sum of up to $10,000,000, subject to the terms herein. On October 31, 2016, Lender advanced $5,000,000 as principal to Borrower and, on May 31, 2017, Lender advanced an additional $2,000,000 as principal to Borrower (collectively, the “ Initial Loan ”). No later than the first business day immediately following the date Borrower and




Lender execute and deliver a contribution agreement in substantially the form agreed to by Borrower and Lender as of June 12, 2017 (such deadline, the “ Execution Date ”), Lender shall loan to Borrower an additional $1,000,000 (the “ Subsequent Loan ”), provided there is not any uncured Event of Default (as defined below) as of the Execution Date. Furthermore, by July 3, 2017, Lender shall loan to Borrower an additional $2,000,000 (or such lesser amount so that the aggregate amount advanced by Lender under this Note after giving effect to such loan totals $10,000,000) (the “ Final Loan ” and collectively with the Initial Loan and the Subsequent Loan, the “ Loan ”), provided that there is not then any uncured Event of Default. Interest shall accrue on the Initial Loan, the Subsequent Loan and the Final Loan, as applicable, from the date of such advance at a per annum rate equal to the lesser of (i) 10.0% and (ii) the maximum interest rate permitted by law.”
3.      Amendment to Section 4 of the Note . The first sentence of Section 4 of the Note is hereby amended and restated as follows:
“The Loan, and all amounts owing by Borrower pursuant to this Note shall automatically be deemed forgiven, discharged, cancelled and satisfied in full (and no further amounts shall thereupon be owing by Borrower pursuant to this Note), upon the first to occur of the following events (provided that no Event of Default shall have previously occurred): (i) Borrower raises or receives at least $90 million in gross proceeds after the initial date of issuance of this Note based on the Initial Loan (the “ Issue Date ”) and on or prior to the one-year anniversary of the Issue Date (the “ Deadline ”), excluding proceeds from the Loan, through (a) the sale of capital stock of Borrower in one or more private placement capital- raising transactions, (b) one or more strategic transactions, or (c) a combination of transactions set forth in clauses (a) and (b), or (ii) ) Borrower consummates a firm commitment underwritten initial public offering of common stock of Borrower on or before the Deadline in which Borrower is valued as of immediately prior to the IPO, based on an initial offering price to the public in the IPO, at $1 billion or more; in either case provided that , as of immediately following such forgiveness, the shares of preferred stock of Borrower held by Lender and/or TNK Therapeutics, Inc., a subsidiary of Lender (“ TNK ”), represents at least 25.0% of Borrower’s outstanding shares of capital stock, calculated in the same manner that the Celularity Shares (as defined in the Contribution Agreement) to be issued pursuant to the Contribution Agreement are to be calculated.”
4.      Amendment to Section 14(d) of the Note . Section 14(d) of the Note is hereby amended and restated as follows:




“Henry Ji, Ph.D., David Deming and Jaisim Shah have been, on or before June 2, 2017, appointed to Borrower’s Board of Directors (the “ Board ”) and each committee of the Board (the “ Designation Right ”), in each case to serve until the later to occur of (I) the date immediately prior to the date of the consummation of Borrower’s first firm commitment underwritten public offering pursuant to an effective registration statement filed under the Securities Act of 1933, as amended, and (II) the date this Promissory Note is repaid in full or no longer outstanding (such later date, the “ Termination Date ”); provided that the Designation Right shall terminate in the event the contribution of TNK Therapeutics, Inc. (“ TNK ”) to Borrower (or one of Borrower’s affiliates) is not consummated within ninety (90) days following the date Celgene Corporation completes its entire contribution of the assets to Borrower in accordance with that certain Non-Binding Term Sheet, made as of September 8, 2016, by and between Celularity, Inc. and Celgene (in the form provided to Lender on October 16, 2016).”
5.      Amendment to Section 15 of the Note . Section 15 of the Note is hereby amended and restated as follows:
Covenants . For as long as Lender holds the Designation Right, Borrower covenants that Borrower shall (a) appoint to the Board and each current and future committee of the Board the three individuals designated by Lender in writing to Borrower, including any replacement or successor to any of the foregoing designees of Lender (each, a “ Borrower Designee ”) and (b) maintain the authorized number of members of the Board at no more than ten members. Henry Ji, Ph.D., David Deming and Jaisim Shah are the initial Borrower Designees.”
6.      Miscellaneous . Except as specifically set forth herein, all of the terms and provisions of the Notes shall remain unchanged, unmodified and in full force and effect, and each of the Notes shall be read together with and construed with this Amendment. This Amendment may be executed in any number of counterparts, all of which when taken together shall constitute one and the same amendatory instrument and any of the parties hereto may executed this Amendment by signing one counterpart. Any signature page delivered by facsimile or e-mail transmission of images in Adobe PDF or similar format shall be binding to the same extent as an original signature page.
[Signature Page Follows]





IN WITNESS WHEREOF , the parties have executed this Amendment No. 1 to Promissory Note as of the date first written above.


BORROWER:
LENDER:
Celularity, Inc.
Sorrento Therapeutics, Inc.
By: /s/ Robert Hariri               
Name: Robert Hariri  
Its: Chief Executive Officer
By: /s/ Henry Ji, Ph.D.            
Name: Henry Ji, Ph.D.  
Its: President & Chief Executive Officer
 
 


[SIGNATURE PAGE TO AMENDMENT NO. 1 TO PROMISSORY NOTE]

Exhibit 10.6
*** Text Omitted and Filed Separately
Confidential Treatment Requested
Under 17 C.F.R. §§ 200.80(b)(4)
and 240.24b-2


AMENDMENT NO. 1 TO
CONTRIBUTION AGREEMENT

THIS AMENDMENT NO. 1 TO CONTRIBUTION AGREEMENT (this “ Amendment ”) is made as of June 30, 2017 by and among Celularity Inc., a Delaware corporation (the “ Celularity ”) and TNK Therapeutics, Inc., a Delaware corporation (“ TNK ”).

RECITALS

A.    Celularity, TNK and Sorrento Therapeutics, Inc., a Delaware corporation have previously entered into that certain Contribution Agreement, dated June 12, 2017 (the “ Contribution Agreement ”).

B.    Pursuant to Section 11.2 of the Contribution Agreement, the Contribution Agreement may be amended upon the written consent of Celularity and TNK.

D.    Borrower and Lender now desire to amend the Contribution Agreement as set forth herein.

NOW THEREFORE , in consideration of the foregoing recitals and the mutual agreements contained herein, the parties hereto, intending to be legally bound, hereby agree as follows:

1. Definitions; Construction . Capitalized terms not otherwise defined herein shall have the meanings set forth in the Contribution Agreement. References in the Contribution Agreement to “this Agreement” (and indirect references such as “hereunder”, “hereby”, “herein” and “hereof”) shall be deemed to be references to the Contribution Agreement as amended hereby.

2. Amendment to Definition of “Celularity Shares” . The definition of “Celularity Shares” set forth in Article I of the Contribution Agreement is hereby amended and restated to read as follows:

Celularity Shares ” means that number of shares of Celularity’s Series A Preferred Stock equal to 25.0% of Celularity’s outstanding shares of capital stock on the Closing Date, calculated on a fully-diluted basis after giving effect to (i) the issuance of such shares of Celularity’s Series A Preferred Stock to TNK and assuming full exercise of all outstanding options, warrants and other rights to purchase capital stock of Celularity and full conversion of all securities convertible into capital stock of Celularity and including all shares reserved or authorized for issuance under Celularity’s equity or other plans, (ii) the issuance of Celularity securities pursuant to the Merger Agreement, (iii) the issuance of Celularity securities pursuant to the Financing, (iv) the issuance of any Celularity securities pursuant to the […***…] Acquisition, and (v) the issuance of Celularity securities to […***…] pursuant to a License Agreement to be entered

* Confidential Treatment Requested



into by and between […***…] and Celularity in connection with the closing of the Financing.
3. Amendment to Definition of “Financing” . The definition of “Financing” set forth in Article I of the Contribution Agreement is hereby amended and restated to read as follows:

Financing ” means the issuance and sale of Series A Preferred Stock in one or more capital-raising transactions (including the conversion of outstanding indebtedness other than the Sorrento Note), which results in gross cash proceeds to Celularity of not less than $[…***…].
     
4. Miscellaneous . Except as specifically set forth herein, all of the terms and provisions of the Contribution Agreement shall remain unchanged, unmodified and in full force and effect, and the Contribution Agreement shall be read together with and construed with this Amendment. This Amendment may be executed in any number of counterparts, all of which when taken together shall constitute one and the same amendatory instrument and any of the parties hereto may executed this Amendment by signing one counterpart. Any signature page delivered by facsimile or e-mail transmission of images in Adobe PDF or similar format shall be binding to the same extent as an original signature page.

[Signature Page Follows]



* Confidential Treatment Requested




IN WITNESS WHEREOF , the parties have executed this Amendment No. 1 to Contribution Agreement as of the date first written above.



CELULARITY:

 
TNK:
Celularity, Inc.

By:   /s/ Robert Hariri               
Name: Robert Hariri  
Its: Chief Executive Officer
 
TNK Therapeutics, Inc.

By:   /s/ Henry Ji, Ph.D.            
Name: Henry Ji, Ph.D.    
Its: Chief Executive Officer




[ SIGNATURE PAGE TO AMENDMENT NO. 1 TO CONTRIBUTION AGREEMENT ]

Exhibit 10.7

AMENDMENT NO. 2 TO
PROMISSORY NOTE

THIS AMENDMENT NO. 2 TO PROMISSORY NOTE (this “ Amendment ”) is made as of June 30, 2017 by and among Celularity Inc., a Delaware corporation (the “ Borrower ”) and Sorrento Therapeutics, Inc., a Delaware corporation (“ Lender ”).

RECITALS

A.    Borrower has previously issued to Lender that certain Promissory Note, dated as of October 31, 2016, in the original principal amount of up to $10,000,000, as amended by that certain Amendment No. 1 to Promissory Note, dated as of June 12, 2017 (collectively, the “ Note ”).

B.    Pursuant to Section 16 of the Note, the Note may be amended upon the written consent of the Borrower and Lender.

C.    Borrower and Lender now desire to amend Section 4 of the Note.

NOW THEREFORE , in consideration of the foregoing recitals and the mutual agreements contained herein, Borrower and Lender, intending to be legally bound, hereby agree as follows:

1. Definitions; Construction . Capitalized terms not otherwise defined herein shall have the meanings set forth in the Note. References in the Note to “this Note” (and indirect references such as “hereunder”, “hereby”, “herein” and “hereof”) shall be deemed to be references to the Note as amended hereby.
   
2. Amendment to Section 4 of the Note . The first sentence of Section 4 of the Note is hereby amended and restated as follows:

“The Loan, and all amounts owing by Borrower pursuant to this Note shall automatically be deemed forgiven, discharged, cancelled and satisfied in full (and no further amounts shall thereupon be owing by Borrower pursuant to this Note), upon the first to occur of the following events (provided that no Event of Default shall have previously occurred): (i) Borrower raises or receives at least $40 million in gross proceeds after the initial date of issuance of this Note based on the Initial Loan (the “ Issue Date ”) and on or prior to the one-year anniversary of the Issue Date (the “ Deadline ”), excluding proceeds from the Loan, through (a) the sale of capital stock of Borrower in one or more private placement capital-raising transactions, (b) one or more strategic transactions, or (c) a combination of transactions set forth in clauses (a) and (b), or (ii) ) Borrower consummates a firm commitment underwritten initial public offering of common stock of Borrower on or before the Deadline in which Borrower is valued as of immediately prior to the IPO, based on an initial offering price to the public in the IPO, at $1 billion or more; in either case provided that , as of immediately following such forgiveness, the shares of preferred stock of Borrower held by Lender and/or TNK Therapeutics, Inc., a




subsidiary of Lender (“ TNK ”), represents at least 25.0% of Borrower’s outstanding shares of capital stock, calculated in the same manner that the Celularity Shares (as defined in the Contribution Agreement) to be issued pursuant to the Contribution Agreement are to be calculated.”

3. Miscellaneous . Except as specifically set forth herein, all of the terms and provisions of the Note shall remain unchanged, unmodified and in full force and effect, and the Note shall be read together with and construed with this Amendment. This Amendment may be executed in any number of counterparts, all of which when taken together shall constitute one and the same amendatory instrument and any of the parties hereto may executed this Amendment by signing one counterpart. Any signature page delivered by facsimile or e-mail transmission of images in Adobe PDF or similar format shall be binding to the same extent as an original signature page.

[Signature Page Follows]







IN WITNESS WHEREOF , the parties have executed this Amendment No. 1 to Promissory Note as of the date first written above.



BORROWER:

 
LENDER:
Celularity, Inc.

By:   /s/ Robert Hariri               
Name: Robert Hariri  
Its: Chief Executive Officer
 
Sorrento Therapeutics, Inc.

By:   /s/ Henry Ji, Ph.D.            
Name: Henry Ji, Ph.D.    
Its: President & Chief Executive Officer




[ SIGNATURE PAGE TO AMENDMENT NO. 2 TO PROMISSORY NOTE ]



Exhibit 31.1
CERTIFICATION OF PRINCIPAL EXECUTIVE OFFICER
I, Henry Ji, certify that:
1. I have reviewed this Quarterly Report on Form 10-Q of Sorrento Therapeutics, Inc.;
2. Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this report;
3. Based on my knowledge, the financial statements, and other financial information included in this report, fairly present in all material respects the financial condition, results of operations and cash flows of the registrant as of, and for, the periods presented in this report;
4. The registrant’s other certifying officer and I are responsible for establishing and maintaining disclosure controls and procedures (as defined in Exchange Act Rules 13a-15(e) and 15d-15(e)) and internal control over financial reporting (as defined in Exchange Act Rules 13a-15(f) and 15d-15(f)) for the registrant and have:
(a) Designed such disclosure controls and procedures, or caused such disclosure controls and procedures to be designed under our supervision, to ensure that material information relating to the registrant, including its consolidated subsidiaries, is made known to us by others within those entities, particularly during the period in which this report is being prepared;
(b) Designed such internal control over financial reporting, or caused such internal control over financial reporting to be designed under our supervision, to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external purposes in accordance with generally accepted accounting principles;
(c) Evaluated the effectiveness of the registrant’s disclosure controls and procedures and presented in this report our conclusions about the effectiveness of the disclosure controls and procedures, as of the end of the period covered by this report based on such evaluation; and
(d) Disclosed in this report any change in the registrant’s internal control over financial reporting that occurred during the registrant’s most recent fiscal quarter (the registrant’s fourth fiscal quarter in the case of an annual report) that has materially affected, or is reasonably likely to materially affect, the registrant’s internal control over financial reporting; and
5. The registrant’s other certifying officer and I have disclosed, based on our most recent evaluation of internal control over financial reporting, to the registrant’s auditors and the audit committee of the registrant’s board of directors (or persons performing the equivalent functions):
(a) All significant deficiencies and material weaknesses in the design or operation of internal control over financial reporting which are reasonably likely to adversely affect the registrant’s ability to record, process, summarize and report financial information; and
(b) Any fraud, whether or not material, that involves management or other employees who have a significant role in the registrant’s internal control over financial reporting.
 
Date:
August 9, 2017
By: 
/s/ Henry Ji, Ph.D.
 
 
 
Henry Ji, Ph.D.
 
 
 
Chairman of the Board of Directors, Chief Executive Officer and President
 
 
 
(Principal Executive Officer)





Exhibit 31.2
CERTIFICATION OF PRINCIPAL FINANCIAL OFFICER
I, Dean Ferrigno, certify that:
1. I have reviewed this Quarterly Report on Form 10-Q of Sorrento Therapeutics, Inc.;
2. Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this report;
3. Based on my knowledge, the financial statements, and other financial information included in this report, fairly present in all material respects the financial condition, results of operations and cash flows of the registrant as of, and for, the periods presented in this report;
4. The registrant’s other certifying officer and I are responsible for establishing and maintaining disclosure controls and procedures (as defined in Exchange Act Rules 13a-15(e) and 15d-15(e)) and internal control over financial reporting (as defined in Exchange Act Rules 13a-15(f) and 15d-15(f)) for the registrant and have:
(a) Designed such disclosure controls and procedures, or caused such disclosure controls and procedures to be designed under our supervision, to ensure that material information relating to the registrant, including its consolidated subsidiaries, is made known to us by others within those entities, particularly during the period in which this report is being prepared;
(b) Designed such internal control over financial reporting, or caused such internal control over financial reporting to be designed under our supervision, to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external purposes in accordance with generally accepted accounting principles;
(c) Evaluated the effectiveness of the registrant’s disclosure controls and procedures and presented in this report our conclusions about the effectiveness of the disclosure controls and procedures, as of the end of the period covered by this report based on such evaluation; and
(d) Disclosed in this report any change in the registrant’s internal control over financial reporting that occurred during the registrant’s most recent fiscal quarter (the registrant’s fourth fiscal quarter in the case of an annual report) that has materially affected, or is reasonably likely to materially affect, the registrant’s internal control over financial reporting; and
5. The registrant’s other certifying officer and I have disclosed, based on our most recent evaluation of internal control over financial reporting, to the registrant’s auditors and the audit committee of the registrant’s board of directors (or persons performing the equivalent functions):
(a) All significant deficiencies and material weaknesses in the design or operation of internal control over financial reporting which are reasonably likely to adversely affect the registrant’s ability to record, process, summarize and report financial information; and
(b) Any fraud, whether or not material, that involves management or other employees who have a significant role in the registrant’s internal control over financial reporting.
 
Date:
August 9, 2017
By: 
/s/ Dean Ferrigno
 
 
 
Dean Ferrigno
 
 
 
Chief Accounting Officer
 
 
 
(Principal Financial and Accounting Officer)





Exhibit 32.1
CERTIFICATIONS OF
PRINCIPAL EXECUTIVE OFFICER AND PRINCIPAL FINANCIAL OFFICER
PURSUANT TO SECTION 906 OF THE SARBANES-OXLEY ACT OF 2002
I, Henry Ji, Principal executive officer of Sorrento Therapeutics, Inc. (the “Company”), certify, pursuant to Section 906 of the Sarbanes-Oxley Act of 2002, 18 U.S.C. Section 1350, that to my knowledge:
1. The Quarterly Report on Form 10-Q of the Company for the period ended June 30, 2017 (the “Report”) fully complies with the requirements of Section 13(a) or 15(d) of the Securities Exchange Act of 1934, as amended; and
2. The information contained in the Report fairly presents, in all material respects, the financial condition and results of operations of the Company.
 
Date:
August 9, 2017
By: 
/s/ Henry Ji, Ph.D.
 
 
 
Henry Ji, Ph.D.
 
 
 
Chairman of the Board of Directors, Chief Executive Officer and President
 
 
 
(Principal Executive Officer)
I, Dean Ferrigno, Principal financial and accounting officer of Sorrento Therapeutics, Inc. (the “Company”), certify, pursuant to Section 906 of the Sarbanes-Oxley Act of 2002, 18 U.S.C. Section 1350, that to my knowledge:
1. The Quarterly Report on Form 10-Q of the Company for the period ended June 30, 2017 (the “Report”) fully complies with the requirements of Section 13(a) or 15(d) of the Securities Exchange Act of 1934; and
2. The information contained in the Report fairly presents, in all material respects, the financial condition and results of operations of the Company.
 
Date:
August 9, 2017
By: 
/s/ Dean Ferrigno
 
 
 
Dean Ferrigno
 
 
 
Chief Accounting Officer
 
 
 
(Principal Financial and Accounting Officer)
A signed original of these certifications has been provided to Sorrento Therapeutics, Inc. and will be retained by Sorrento Therapeutics, Inc. and furnished to the Securities and Exchange Commission or its staff upon request.
These certifications are being furnished solely to accompany this quarterly report pursuant to 18 U.S.C. Section 1350, and shall not be deemed filed for purposes of Section 18 of the Securities Exchange Act of 1934 and are not to be incorporated by reference into any filing of Sorrento Therapeutics, Inc., whether made before or after the date hereof, regardless of any general incorporation language in such filing.