As filed with the Securities and Exchange Commission on August 8, 2019
Registration No. 333-  ________


UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
 
FORM S-8
REGISTRATION STATEMENT
UNDER
THE SECURITIES ACT OF 1933
 
Ligand Pharmaceuticals Incorporated
(Exact Name of Registrant as Specified in Its Charter)

Delaware
 
77-0160744
(State or other jurisdiction of incorporation or organization)
 
(I.R.S. Employer Identification No.)

 
3911 Sorrento Valley Boulevard, Suite 110
San Diego, CA 92121
(Address of Principal Executive Offices)
 

Ligand Pharmaceuticals Incorporated 2002 Stock Incentive Plan, as amended and restated
(Full title of the plan)
 

John L. Higgins
Chief Executive Officer
Ligand Pharmaceuticals Incorporated
3911 Sorrento Valley Boulevard, Suite 110
San Diego, CA 92121
(Name and address of agent for service)
(858) 550-7500
(Telephone number, including area code, of agent for service)

 
Copies to:
Matthew T. Bush, Esq.
Anthony Gostanian, Esq.
Latham & Watkins LLP
12670 High Bluff Drive
San Diego, CA 92130
(858) 523-5400

 

Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, or a smaller reporting company. See the definitions of “large accelerated filer,” “accelerated filer” and “smaller reporting company” in Rule 12b-2 of the Exchange Act.







Large accelerated filer   x
 
Accelerated filer   o
Non-accelerated filer   o  (do not check if a smaller reporting company)
 
Smaller reporting company o

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of the Securities Act. ☐






CALCULATION OF REGISTRATION FEE



Title of Securities to be Registered


Amount
to be
Registered (1)

Proposed
Maximum
Offering Price
Per Share (2)

Proposed Maximum
Aggregate
Offering Price (2)


Amount of
Registration
Fee
Ligand Pharmaceuticals Incorporated   2002 Stock Incentive Plan, as amended and restated
Common Stock, $0.001 par value (3)    
820,0003 (3)
$93.12
$76,358,400
$9,254.64

(1)
Pursuant to Rule 416(a) under the Securities Act of 1933, as amended, this Registration Statement shall also cover any additional shares of common stock which become issuable under the above-named plan by reason of any stock dividend, stock split, recapitalization or any other similar transaction effected without the receipt of consideration which results in an increase in the number of the Registrant’s outstanding shares of common stock.
(2)
This estimate is made pursuant to paragraphs (c) and (h) of Rule 457 solely for purposes of calculating the registration fee, and is based on the average of the high and low sale prices for the Registrant’s common stock as reported on the Nasdaq Global Market on August 5, 2019, within five business days prior to filing.
(3)
This Registration Statement registers the issuance of an additional 820,000 shares of common stock, which are issuable under the Ligand Pharmaceuticals Incorporated 2002 Stock Incentive Plan, as amended and restated (the “2002 Plan”). The amendment and restatement, which authorized the issuance of such additional shares, was approved by the stockholders of the Registrant on June 6, 2019.

Proposed sales to take place as soon after the effective date of this Registration Statement
as awards granted under the 2002 Plan are granted, exercised and/or distributed.








EXPLANATORY NOTE

This Registration Statement on Form S-8 registers the offer and sale of an additional 820,000 shares of common stock available for issuance under the Ligand Pharmaceuticals Incorporated 2002 Stock Incentive Plan, as amended and restated (the “2002 Plan”). The amendment and restatement of the 2002 Plan, which authorized the increase of the additional shares, was approved by our stockholders on June 6, 2019.

We previously filed a Registration Statement on Form S-1 (File No. 333-131029) with the Securities and Exchange Commission (the “Commission”), to register shares of common stock available for issuance under the 2002 Plan at a time when Ligand was not eligible to file a Registration Statement on Form S-8. However, Ligand later became eligible to file a Registration Statement on Form S-8 and opted to file a Post-Effective Amendment No. 2 on Form S-8 to the Registration Statement on Form S-1 for the purpose of converting the Registration Statement on Form S-1 into a Registration Statement on Form S-8. Please see the Registration Statement on Form S-1 filed with the Commission on January 13, 2006, Amendment No. 1 to Form S-1 Registration Statement filed with the Commission on February 10, 2006, Post-Effective Amendment No. 2 on Form S-8 to Form S-1 Registration Statement filed with the Commission on June 18, 2007 for further detail. In accordance with Instruction E to Form S-8, the contents of these prior registration statements and the registration statements on Form S-8, File No. 333-182547, File No. 333-160132, File No. 333-117129, File No. 333-106375, File No. 333-91414 and File No. 333-212775 previously filed with respect to the 2002 Plan, are hereby incorporated by reference.

PART I

The documents containing the information specified in Part I of Form S-8 will be sent or given to participants as specified by Rule 428(b)(1) of the Securities Act. These documents and the documents incorporated by reference into this Registration Statement pursuant to Item 3 of Part II of this Registration Statement, taken together, constitute a prospectus that meets the requirements of Section 10(a) of the Securities Act.

PART II

Item 3. Incorporation of Documents by Reference.
 
The Commission allows us to incorporate by reference the information we file with it, which means that we can disclose important information to you by referring to those documents. The information incorporated by reference is an important part of this Registration Statement, and information that we file later with the Commission will automatically update and supersede this information. We incorporate by reference the following documents we have filed, or may file, with the Commission:

(1)
the description of our common stock contained in our Registration Statement on Form 8-A filed with the Commission on November 21, 1994, and any amendment or report filed for the purpose of updating such description;
(2)
our Annual Report on Form 10-K for the fiscal year ended December 31, 2018 filed with the Commission on February 28, 2019;
(3)
our Quarterly Reports on Form 10-Q for the fiscal quarters ended March 31, 2019 and June 30, 2019, filed with the Commission on May 9, 2019 and August 8, 2019, respectively;
(4)
our Current Reports on Form 8-K filed with the Commission on January 25, 2019, January 28, 2019, February 7, 2019, March 5, 2019, March 6, 2019, April 22, 2019, May 24, 2019, June 3, 2019, June 10, 2019, June 12, 2019, July 3, 2019 and July 24, 2019; and
(5)
all documents filed by us with the Commission pursuant to Sections 13(a), 13(c), 14 or 15(d) of the Securities Exchange Act of 1934, as amended (the “Exchange Act”), after the date of this Registration Statement and prior to the termination of this offering of securities.
Any statement incorporated herein shall be deemed to be modified or superseded for purposes of this prospectus to the extent that a statement contained herein or in any other subsequently filed document which also is or is

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deemed to be incorporated by reference herein modifies or supersedes such statement. Any statement so modified or superseded shall not be deemed, except as so modified or superseded, to constitute a part of this prospectus. Under no circumstances will any information filed under current item 2.02 or 7.01 of Form 8-K or related exhibits furnished pursuant to current item 9.01 of Form 8-K be deemed incorporated herein by reference unless such Form 8-K expressly provides to the contrary.        

Item 4. Description of Securities.

Not applicable.

Item 5. Interests of Named Experts and Counsel.

Not applicable.

Item 6. Indemnification of Directors and Officers.

As permitted by Section 102 of the Delaware General Corporation Law, we have adopted provisions in our certificate of incorporation and Bylaws that limit or eliminate the personal liability of our directors for a breach of their fiduciary duty of care as a director. The duty of care generally requires that, when acting on behalf of the corporation, directors exercise an informed business judgment based on all material information reasonably available to them. Consequently, a director will not be personally liable to us or our stockholders for monetary damages or breach of fiduciary duty as a director, except for liability for: any breach of the director’s duty of loyalty to us or our stockholders; any act or omission not in good faith or that involves intentional misconduct or a knowing violation of law; any act related to unlawful stock repurchases, redemptions or other distributions or payment of dividends; or any transaction from which the director derived an improper personal benefit.

These limitations of liability do not affect the availability of equitable remedies such as injunctive relief or rescission. As permitted by Section 145 of the Delaware General Corporation Law, the certificates of incorporation and Bylaws provide that we may indemnify our directors, officers, employees and agents to the fullest extent permitted by the Delaware General Corporation Law, subject to limited exceptions; we may advance expenses to our directors and officers in connection with a legal proceeding to the fullest extent permitted by the Delaware General Corporation Law, subject to limited exceptions; and the rights provided in the certificates of incorporation and Bylaws are not exclusive.

In addition, we have entered into separate indemnification agreements with our directors and officers which may be broader than the specific indemnification provisions contained in the Delaware General Corporation Law. These indemnification agreements may require us, among other things, to indemnify our officers and directors against liabilities that may arise by reason of their status or service as directors or officers, other than liabilities arising from willful misconduct. These indemnification agreements also may require us to advance any expenses incurred by the directors or officers as a result of any proceeding against them as to which they could be indemnified. In addition, we have purchased a policy of directors’ and officers’ liability insurance that insures our directors and officers against the cost of defense, settlement or payment of a judgment in some circumstances. These indemnification provisions and the indemnification agreements may be sufficiently broad to permit indemnification of our officers and directors for liabilities, including reimbursement of expenses incurred, arising under the Securities Act of 1933, as amended (the “Securities Act”).

Item 7. Exemption from Registration Claimed.

Not applicable.


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Item 8. Exhibits.

   
 
 
 
 
 
 
 
 
 
 
 
Exhibit
Number
Exhibit Description
 
Incorporated by Reference
 
Filed
Herewith
 
Form
 
File No.
 
 
 
Filing Date
 
 
 
 
 
 
 
 
Amended and Restated Certificate of Incorporation of the Company
 
S-4
 
333-58823
 
3.1
 
07/09/1998
 
 
 
 
 
 
 
 
 
   3.2
Third Amended and Restated Bylaws of the Company
 
8-K
 
001-33093
 
3.1
 
09/10/2015
 
 
 
 
 
 
 
 
 
   3.3
Certificate of Amendment of the Amended and Restated Certificate of Incorporation of the Company dated June 14, 2000
 
10-K
 
000-20720
 
3.5
 
03/29/2001
 
 
 
 
 
 
 
 
 
Certificate of Amendment of the Amended and Restated Certificate of Incorporation of the Company dated June 30, 2004
 
10-Q
 
000-20720
 
3.6
 
08/05/2004
 
 
 
 
 
 
 
 
 
Certificate of Amendment of the Amended and Restated Certificate of Incorporation of the Company, dated November 17, 2010
 
8-K
 
001-33093
 
3.1
 
11/19/2010
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Certificate of Amendment of the Amended and Restated Certificate of Incorporation of the Company, dated June 19, 2018
 
 
 
 
 
 
 
 
 
X
 
 
 
 
 
 
 
Specimen stock certificate for shares of the common stock of the Company
 
10-K
 
001-33093
 
4.1
 
03/01/2018
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Opinion of Latham & Watkins LLP
 
 
 
 
 
 
 
 
 
X
 
 
 
 
 
 
 
2002 Stock Incentive Plan, as amended and restated
 
DEF 14A
 
001-33093
 
Appendix A
 
04/24/2019
 
 
 
 
 
 
 
 
 
Consent of Independent Registered Public Accounting Firm
 
 
 
 
 
 
 
 
 
X
 
 
 
 
 
 
 
23.2
Consent of Latham & Watkins LLP (included in Exhibit 5.1 hereto)
 
 
 
 
 
 
 
 
 
X
 
 
 
 
 
 
 
24.1
Power of Attorney (see signature page)
 
 
 
 
 
 
 
 
 
X

Item 9. Undertakings.

(a) The undersigned registrant hereby undertakes:

(1) To file, during any period in which offers or sales are being made, a post-effective amendment to this registration statement:

            (i) To include any prospectus required by Section 10(a)(3) of the Securities Act of 1933;

(ii) To reflect in the prospectus any facts or events arising after the effective date of this registration statement (or the most recent post-effective amendment thereof) which, individually or in the aggregate, represent a fundamental change in the information set forth in the registration statement. Notwithstanding the foregoing, any increase or decrease in volume of securities offered (if the total dollar value of securities offered would not exceed that which was registered) and any deviation from the low or high end of the estimated maximum offering range may be reflected in the form of prospectus filed with the Commission pursuant to Rule 424(b) if, in the aggregate, the changes in volume and price represent no more than a 20 percent change in the maximum aggregate offering price set forth in the “Calculation of Registration Fee” table in the effective registration statement; and


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(iii) To include any material information with respect to the plan of distribution not previously disclosed in the registration statement or any material change to such information in the registration statement;

Provided, however , that the undertakings set forth in paragraphs (a)(1)(i), (a)(1)(ii) and (a)(1)(iii) above do not apply if the registration statement is on Form S-3 or Form F-3 and the information required to be included in a post-effective amendment by those paragraphs is contained in reports filed with or furnished to the Commission by the registrant pursuant to Section 13 or Section 15(d) of the Securities Exchange Act of 1934 that are incorporated by reference in the registration statement.

(2) That, for the purpose of determining any liability under the Securities Act of 1933, each such post-effective amendment shall be deemed to be a new registration statement relating to the securities offered therein, and the offering of such securities at that time shall be deemed to be the initial bona fide offering thereof.

(3) To remove from registration by means of a post-effective amendment any of the securities being registered which remain unsold at the termination of the offering.

(b) The undersigned registrant hereby undertakes that, for purposes of determining any liability under the Securities Act of 1933, each filing of the registrant’s annual report pursuant to Section 13(a) or 15(d) of the Securities Exchange Act of 1934 (and, where applicable, each filing of an employee benefit plan’s annual report pursuant to Section 15(d) of the Securities Exchange Act of 1934) that is incorporated by reference in the registration statement shall be deemed to be a new registration statement relating to the securities offered therein, and the offering of such securities at that time shall be deemed to be the initial bona fide offering thereof.

(c) Insofar as indemnification for liabilities arising under the Securities Act of 1933 may be permitted to directors, officers and controlling persons of the registrant pursuant to the foregoing provisions or otherwise, the registrant has been advised that in the opinion of the Securities and Exchange Commission such indemnification is against public policy as expressed in the Securities Act of 1933 and is therefore unenforceable. In the event that a claim for indemnification against such liabilities (other than the payment by the registrant of expenses incurred or paid by a director, officer or controlling person of the registrant in the successful defense of any action, suit or proceeding) is asserted by such director, officer or controlling person in connection with the securities being registered, the registrant will, unless in the opinion of its counsel the matter has been settled by controlling precedent, submit to a court of appropriate jurisdiction the question whether such indemnification by it is against public policy as expressed in the Securities Act of 1933, and will be governed by the final adjudication of such issue.

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SIGNATURES

Pursuant to the requirements of the Securities Act of 1933, as amended, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of San Diego, State of California, on August 8, 2019.
   
Ligand Pharmaceuticals Incorporated
 
 
By
 
/s/ John L. Higgins
 
 
John L. Higgins
Chief Executive Officer

        
POWER OF ATTORNEY

KNOW ALL PERSONS BY THESE PRESENTS, that each person whose signature appears below hereby constitutes and appoints John L. Higgins, Matthew Korenberg and Charles S. Berkman, and each of them acting individually, as his or her attorney-in-fact, each with full power of substitution, for him or her in any and all capacities, to sign any and all amendments to this Registration Statement on Form S-8 (including post-effective amendments), and to file the same, with exhibits thereto and other documents in connection therewith, with the Securities and Exchange Commission, hereby ratifying and confirming all that each of said attorneys-in-fact, or any substitute, may do or cause to be done by virtue hereof.

Pursuant to the requirements of the Securities Act of 1933, as amended, this Registration Statement has been signed by the following persons in the capacities and on the dates indicated:
       






 
 
 
 
 
Signature
 
Title
 
Date
 
 
 
/ s /    John L. Higgins         
John L. Higgins
 
Chief Executive Officer and
Director (Principal Executive Officer)
 
August 8, 2019
 
 
 
/ s /    Matthew Korenberg         
Matthew Korenberg
 
Executive Vice President, Finance and Chief
Financial Officer (Principal Financial
Officer and Principal Accounting Officer)
 
August 8, 2019
 
 
 
 
 
/ s /    John W. Kozarich         
John W. Kozarich
 
Chairman
 
August 8, 2019
 
 
 
/ s /    Jason M. Aryeh         
Jason M. Aryeh
 
Director
 
August 8, 2019
 
 
 
/ s /    John L. LaMattina         
John L. LaMattina
 
Director
 
August 8, 2019
 
 
 
/ s /    Todd C. Davis         
Todd C. Davis
 
Director
 
August 8, 2019
 
 
 
/ s /    Nancy Ryan Gray
Nancy Ryan Gray
 
Director
 
August 8, 2019
 
 
 
/ s /    Stephen L. Sabba         
Stephen L. Sabba
 
Director
 
August 8, 2019
 
 
 
/ s /    Sunil Patel         
Sunil Patel
 
Director
 
August 8, 2019




Exhibit 3.6

CERTIFICATE OF AMENDMENT
OF THE AMENDED AND RESTATED
CERTIFICATE OF INCORPORATION
OF
LIGAND PHARMACEUTICALS INCORPORATED
A DELAWARE CORPORATION
Ligand Pharmaceuticals Incorporated (the “Corporation”), a corporation organized and existing under and by virtue of the General Corporation Law of the State of Delaware (the “DGCL”), does hereby certify:
FIRST: That resolutions were duly adopted by the Board of Directors of the Corporation setting forth a proposed amendment to the Amended and Restated Certificate of Incorporation of the Corporation, and declaring said amendment to be advisable and recommended for approval by the stockholders of the Corporation. The resolutions setting forth the proposed amendment are as follows:
RESOLVED, that Paragraph (A) of ARTICLE IV of the Amended and Restated Certificate of Incorporation of this Corporation is hereby amended to read in its entirety as follows:
“(A) CLASSES OF STOCK. This corporation is authorized to issue two classes of stock to be designated, respectively, “Common Stock” and “Preferred Stock.” The total number of shares of all classes of capital stock that this corporation shall have authority to issue is sixty-five million (65,000,000), of which sixty million (60,000,000) shares of the par value of one-tenth of one cent ($.001) each shall be Common Stock and five million (5,000,000) shares of the par value of one-tenth of one cent ($.001) each shall be Preferred Stock. The number of authorized shares of Common Stock may be increased or decreased (but not below the number of shares thereof then outstanding) by the affirmative vote of the holders of the majority of the shares of stock of this corporation entitled to vote in the election of directors.”
SECOND: That, thereafter, the stockholders of said Corporation approved the amendment by vote of the outstanding shares in accordance with Section 222 of the DGCL.
THIRD: That said amendment was duly adopted in accordance with the provisions of Section 242 of the DGCL.
IN WITNESS WHEREOF, this Certificate of Amendment of Amended and Restated Certificate of Incorporation has been executed as of this 19 th day of June, 2018.

 
 
 
 
 
 
LIGAND PHARMACEUTICALS INCORPORATED
 
By:
 
/s/ Charles S. Berkman
 
 
Name:
 
Charles S. Berkman
 
 
Title:
 
Senior Vice President, General Counsel and Secretary




Exhibit 5.1

EXHIBIT51OPINIONAUGUS_IMAGE1.GIF

12670 High Bluff Drive
San Diego, California 92130
Tel: +1.858.523.5400 Fax: +1.858.523.5450
www.lw.com
FIRM / AFFILIATE OFFICES
Beijing          Moscow
Boston          Munich
Brussels          New York
Century City      Orange County
Chicago          Paris
Dubai          Riyadh
Düsseldorf          San Diego
Frankfurt          San Francisco
Hamburg          Seoul
Hong Kong          Shanghai
Houston          Silicon Valley
London          Singapore
Los Angeles      Tokyo
Madrid          Washington, D.C.
Milan     

August 8, 2019


Ligand Pharmaceuticals Incorporated
3911 Sorrento Valley Boulevard, Suite 110
San Diego, CA 92121

Re:
Registration Statement on Form S-8: 820,000 Shares of Common Stock, par value $0.001 per share to be registered under the Ligand Pharmaceuticals Incorporated 2002 Stock Incentive Plan, as amended and restated

Ladies and Gentlemen:

We have acted as special counsel to Ligand Pharmaceuticals Incorporated, a Delaware corporation (the “ Company ”), in connection with the proposed issuance of 820,000 shares (the “ Shares ”) of common stock, par value $0.001 per share, of the Company (“ Common Stock ”), issuable pursuant to the Company’s 2002 Stock Incentive Plan, as amended and restated (the “ 2002 Plan ”). The Shares are included in a registration statement on Form S-8 under the Securities Act of 1933, as amended (the “ Act ”), filed with the Securities and Exchange Commission (the “ Commission ”) on August 8, 2019 (the “ Registration Statement ”). This opinion is being furnished in connection with the requirements of Item 601(b)(5) of Regulation S-K under the Act, and no opinion is expressed herein as to any matter pertaining to the contents of the Registration Statement, other than as expressly stated herein with respect to the issue of the Shares.

As such counsel, we have examined such matters of fact and questions of law as we have considered appropriate for purposes of this letter. With your consent, we have relied upon certificates and other assurances of officers of the Company and others as to factual matters without having independently verified such factual matters. We are opining herein only as to the General Corporation Law of the State of Delaware, and we express no opinion with respect to any other laws.



August 8, 2019
Page 2
EXHIBIT51OPINIONAUGUS_IMAGE1.GIF

In our examination, we have assumed the genuineness of all signatures, the authenticity of all documents submitted to us as originals and the conformity to authentic original documents of all documents submitted to us as copies.
Subject to the foregoing and the other matters set forth herein, it is our opinion that, as of the date hereof, when the Shares have been duly registered on the books of the transfer agent and registrar therefor in the name or on behalf of the recipients, or certificates representing the Shares have been manually signed by an authorized officer of the transfer agent and registrar therefor, and subject to the Company completing all actions and proceedings required on its part to be taken prior to the issuance of the Shares, and when the Shares have been issued by the Company against payment therefor (not less than par value) in the circumstances contemplated by the 2002 Plan, the issuance and sale of the Shares will have been duly authorized by all necessary corporate action of the Company, and the Shares will be validly issued, fully paid and nonassessable. In rendering the foregoing opinion, we have assumed that the Company will comply with all applicable notice requirements regarding uncertificated shares provided in the General Corporation Law of the State of Delaware.
This opinion is for your benefit in connection with the Registration Statement and may be relied upon by you and by persons entitled to rely upon it pursuant to the applicable provisions of the Act. We consent to your filing this opinion as an exhibit to the Registration Statement. In giving such consent, we do not thereby admit that we are in the category of persons whose consent is required under Section 7 of the Act or the rules and regulations of the Commission thereunder.


Very truly yours,

/s/ Latham & Watkins LLP
                        


Exhibit 23.1

CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM

We consent to the incorporation by reference in the Registration Statement (Form S-8) pertaining to the Ligand Pharmaceuticals Incorporated 2002 Stock Incentive Plan, as amended and restated of our reports dated February 28, 2019, with respect to the consolidated financial statements of Ligand Pharmaceuticals Incorporated and the effectiveness of internal control over financial reporting of Ligand Pharmaceuticals Incorporated included in its Annual Report (Form 10-K) for the year ended December 31, 2018, filed with the Securities and Exchange Commission.

/s/Ernst & Young LLP

San Diego, California
August 8, 2019