UNITED STATES
SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

FORM 8-K

CURRENT REPORT
Pursuant to Section 13 or 15(d) of
the Securities Exchange Act of 1934

Date of Report (Date of earliest event reported): October 28, 2005

INTEGRA LIFESCIENCES HOLDINGS CORPORATION
(Exact name of Registrant as specified in its charter)

           Delaware                      0-26224                51-0317849
(State or other jurisdiction of  (Commission File Number)    (I.R.S. Employer
 incorporation or organization)                             Identification No.)

311 Enterprise Drive
Plainsboro, NJ 08536
(Address of principal executive offices) (Zip Code)

Registrant's telephone number, including area code: (609) 275-0500

Not Applicable
(Former name or former address, if changed since last report)

Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions:

[ ] Written communications pursuant to Rule 425 under the Securities Act


(17 CFR 230.425)

[ ] Soliciting material pursuant to Rule 14a-12 under the Exchange Act


(17 CFR 240.14a-12)

[ ] Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchang Act (17 CFR 240.14d-2(b))

[ ] Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchang Act (17 CFR 240.13e-4(c))


ITEM 1.01. ENTRY INTO A MATERIAL DEFINITVE AGREEMENT.

On October 28, 2005, Integra LifeSciences Corporation ("ILS"), a wholly-owned subsidiary of Integra LifeSciences Holdings Corporation (the "Company"), entered into a lease modification agreement with Plainsboro Associates relating to its manufacturing facility in Plainsboro, New Jersey. Plainsboro Associates is a New Jersey general partnership. Ocirne, Inc., a subsidiary of Provco Industries ("Provco"), owns a 50% interest in Plainsboro Associates. Provco's stockholders are trusts whose beneficiaries include the children of Dr. Richard Caruso, the Chairman and a principal stockholder of the Company. Dr. Caruso is the President of Provco.

The lease modification agreement provides for extension of the term of the lease from October 31, 2012 for an additional five (5) year period through October 31, 2017 at a rate of $11.03 per square foot, or an annual rate of $272,308.64 ($22,692.39 monthly). The lease modification agreement also provides a ten year option for ILS to extend the lease from November 1, 2017 through October 31, 2027 at a fixed rate of $11.97 per square foot, or an annual rate of $295,515.36 ($24,626.28 monthly), for the ten year extension period (the rate is fixed for the entire ten year period).

Prior to the amendment, the lease had an expiration date of October 31, 2012, with an option for ILS to extend the lease for one five (5) year period (November 1, 2012 through October 31, 2017) at a rate of 75% of the then current fair market value.

A copy of the lease modification agreement is attached as Exhibit 10.1 to this Current Report on Form 8-K and is incorporated by reference into this Item.

ITEM 9.01. FINANCIAL STATEMENTS AND EXHIBITS.

(c) Exhibits.

Exhibit Number   Description of Exhibit
--------------   ---------------------------

10.1             Lease Modification #2 entered into as of the 28th day of
                 October, 2005, by and between Plainsboro Associates and
                 Integra LifeSciences Corporation


SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, as amended, the Registrant has duly caused this report to be signed on its behalf by the undersigned, hereunto duly authorized.

INTEGRA LIFESCIENCES HOLDINGS CORPORATION

Date: November 2, 2005             By: /s/ Stuart M. Essig
                                       -----------------------------
                                       Stuart M. Essig
                                       President and Chief Executive Officer


Exhibit Index

Exhibit Number   Description of Exhibit
--------------   ---------------------------

10.1             Lease Modification #2 entered into as of the 28th day of
                 October, 2005, by and between Plainsboro Associates and
                 Integra LifeSciences Corporation


4

LEASE MODIFICATION #2

THIS LEASE MODIFICATION #2 ("Amendment #2") is entered into as of the 28th day of October, 2005, by and between Plainsboro Associates, a New Jersey general partnership, (hereinafter called the "Landlord"), and Integra Lifesciences Corporation, a Delaware Corporation, (hereinafter referred to as "Tenant"). The following statements are a material part of the Amendment #2:

WITNESSETH:

WHEREAS, American Biomaterials Corporation, a Virginia corporation, (hereinafter "ABC"), entered into a Lease Agreement dated April 16, 1985 which was subsequently modified and amended pursuant to the Consent Order Approving Settlement dated October 14, 1988, entered in the United States Bankruptcy Court for the District of New Jersey (hereinafter the "Consent Order") (which together with the aforesaid Lease Agreement is hereinafter referred to as the "ABC Lease") as tenant therein, with Landlord covering approximately 10,020 square feet of space at the address of 105 Morgan Drive, Township of Plainsboro, County of Middlesex, State of New Jersey (Premises "A")

WHEREAS, Helitrex, Inc., a New Jersey Corporation and wholly owned subsidiary of ABC, (hereinafter, "Helitrex"), entered into a Lease Agreement dated October 4, 1983 which was subsequently modified and amended pursuant to Letter Amendments and/or Lease Modification Agreements dated October 4, 1983, November 2, 1983 and September, 1984 and the Consent Order (hereinafter, collectively the "Helitrex Lease") as tenant therein, with Landlord covering approximately 14,668 square feet of space located on Morgan Drive, Township of Plainsboro, County of Middlesex, State of New Jersey (Premises "B")

WHEREAS, ABC assigned the ABC Lease and Helitrex assigned the Helitrex Lease to Colla-Tec, Inc., a Delaware Corporation (hereinafter, "Colla-Tec") pursuant to the Order Confirming the Amended Plan of Reorganization entered by the United States Bankruptcy Court on September 30, 1988, and Colla-Tec accepted said assignment and assumed ABC's and Helitrex's obligations thereunder arising from and after November 2, 1988 and Landlord gave its consent to such assignment;

WHEREAS, on or about November 1, 1992, Colla-Tec and Landlord further amended the ABC Lease and the Helitrex Lease (hereinafter the "Lease Modification");

WHEREAS, Colla-Tec was merged into Tenant;


WHEREAS, Landlord and Tenant desire by this Amendment #2 to further amend the ABC Lease and the Helitrex Lease as hereinafter provided.

NOW, THEREFORE, in consideration of the mutual agreements, covenants and representations herein contained and those contained in the Lease and in reliance thereon, the parties intending to be legally bound hereby mutually agree as follows:

AS TO THE HELITREX LEASE

1. Article II Section 2.01 shall be modified and amended to provide that the Term of the Lease shall be extended to terminate on October 31, 2017.

2. Article III Section 3.01 shall be deleted and in its place shall be the following:

The Tenant shall pay to the Landlord during the Term rent in the amount of three million four hundred and thirteen thousand nine hundred and seventy six dollars and ninety cents ($3,413,976.90) payable in such coin or currency of the United States of America as at the time of payment shall be legal tender for payment of public and private debts.

3. Article III Section 3.02 shall be modified and amended to include the following:

       Lease Year                  Annual                    Monthly

 21 through 25 at $11.03        ($161,788.04)             ($13,482.34)
(11/1/2012 to 10/31/2017)

AS TO THE ABC LEASE

4. Article II Section 2.01 shall be modified and amended to provide that the Term of the Lease shall be extended to terminate on October 31, 2017.

5. Article III Section 3.01 shall be deleted and in its place shall be the following:

The Tenant shall pay to the Landlord during the Term rent in the amount of two million three hundred and thirty-two thousand and one hundred and fifty five dollars and no cents ($2,332,155.00) payable in such coin or currency of the United States of America as at the time of payment shall be legal tender for payment of public and private debts.

6. Article III Section 3.02 shall be modified and amended to include the following:

        Lease Year                   Annual                    Monthly

 21 through 25 at $11.03          ($110,520.60)              ($9,210.05)
(11/1/2012 to 10/31/2017)


AS TO BOTH THE HELITREX AND ABC LEASES

7. In the Lease Modification under the Section titled "As to both the Helitrex and ABC Leases", Paragraph 1 shall be modified and amended to provide that Tenant is hereby granted one (1) option to simultaneously renew both the Helitrex and the ABC Leases together each for an additional term of ten (10) years upon the following terms and conditions:

8. In the Lease Modification under the Section titled "As to both the Helitrex and ABC Leases", Paragraph 1 (D) shall be modified and amended to read as follows:

The tenant shall pay to the Landlord during such renewal term rent in the amount of two million nine hundred fifty-five thousand one hundred fifty-three dollars and sixty cents ($2,955,153.60) payable in such coin or currency of the United States of America as at the time of payment shall be legal tender for payment of public and private debts.

9. In the Lease Modification under the Section titled "As to both the Helitrex and ABC Leases", Paragraph 1 (E) shall be modified and amended to read as follows:

During such renewal term rent shall accrue at the yearly rates and shall be payable in advance on the first day of each calendar month during the renewal term in the installments as follows:

AS TO THE HELITREX LEASE

      Lease Year                   Annual                  Monthly

 26 through 35 at $11.97        ($175,575.96)           ($14,631.33)
(11/1/2017 to 10/31/2027)

AS TO THE ABC LEASE

      Lease Year                   Annual                  Monthly

 26 through 35 at $11.97        ($119,939.40)           ($9,994.95)
(11/1/2017 to 10/31/2027)

10. Tenant reaffirms its acceptance to all other terms and conditions of both the Helitrex Lease and the ABC Lease.


11. To the extent there are any conflicts or inconsistencies between either the Helitrex Lease or the ABC Lease and this Amendment #2, this Amendment #2 and the rights and obligations herein shall govern. All other terms and provisions of the previous agreements between the parties shall remain unaffected by this Amendment.

                                            Tenant:

WITNESS                                     Integra Lifesciences Corporation


/s/ David B. Holtz                          By: /s/ Stuart M. Essig
------------------                          -----------------------


                                            Landlord:

WITNESS                                     Plainsboro Associates

/s/ Barbara T. Keller                       By: /s/ C. Lawrence Keller
---------------------                       --------------------------