Exhibit 10.1
	EMPLOYMENT AGREEMENT
	This EMPLOYMENT AGREEMENT (Agreement) is made effective as of the date of signature by and
	between ENTREMED, INC., a Delaware corporation having its principal office at 9640 Medical Center
	Drive, Rockville, MD 20850 (the Company) and Cynthia Wong (the Executive).
	FOR AND IN CONSIDERATION of the mutual premises, agreements and covenants contained herein, the
	parties hereto, intending to be legally bound, do hereby agree as follows:
	1.
	Employment; Position and Duties.
	Subject to the terms hereof, the Company hereby agrees to employ the Executive during the Term (as
	hereafter defined) to act as, and to exercise all of the powers and functions of, its Vice
	President and General Counsel and to perform such acts and duties and to generally furnish such
	services to the Company and its subsidiaries (if any) as is customary for a senior management
	person with a similar position in like companies, such services to include (a) responsibility for
	overall internal and external legal, contractual and SEC compliance activities, including
	interactions with the SEC and exchange officials, other regulatory agencies and external legal
	counsel, and (b) all duties normally reserved to a companys principal legal officer for the
	Companys legal matters, including retention and engagement of legal counsel and interaction with
	the Board. Executive shall report directly to the Chief Executive Officer (CEO) of the Company
	and have such other powers, duties and responsibilities as the CEO, in consultation with and
	approval of the Board of Directors (the Board), shall from time to time reasonably prescribe.
	Executive will be a member of the Companys Management Committee and Business Development Committee
	and will be Secretary of the Company, subject to approval by the Board as a named officer.
	Executive hereby agrees to accept such employment and shall perform and discharge faithfully,
	diligently, and to the best of her abilities such duties and responsibilities and shall devote
	sufficient working time and efforts to the business and affairs of the Company and its
	subsidiaries.
	2.
	Place of Employment.
	While Executive is employed by the Company during the Term, Executive shall conduct her duties and
	responsibilities hereunder primarily from the executive offices located in Rockville, Maryland
	(except for routine and customary business travel), or from such other location in the Washington
	D.C. metropolitan area as designated from time to time by the CEO.
	3.
	Compensation
	     a. 
	Base Salary.
	While the Company employs Executive during the Term, the Company
	shall pay to Executive an annual base salary (Base Salary) of no less than $216,000, payable in
	accordance with the Companys customary payroll policy for its executives.
	 
 
	 
	     b. 
	Base Salary Adjustments.
	Executives Base Salary shall be reviewed at least
	annually in accordance with the Companys customary practices for its executives. The Board or a
	committee thereof may make such adjustments, as it deems appropriate in its sole discretion;
	provided, however, in no event shall the Company pay Executive a Base Salary of less than $216,000.
	In making such adjustments the Board or a committee thereof may solicit and give consideration to
	the views of the CEO.
	     c. 
	Incentive Compensation.
	While the Company employs Executive during the Term,
	Executives annual incentive compensation (Incentive Compensation) shall be targeted at 25% of
	Base Salary, the exact amount of which shall be determined by the Board or a committee thereof in
	its sole discretion. Executive shall be eligible for Incentive Compensation commencing at the start
	of the Initial Term. Such bonus, if any, shall be paid within ninety (90) days following the last
	day of each fiscal year of the Company. In making such determinations, the Board or a committee
	thereof may solicit and take into consideration the views of the CEO.
	     d. 
	Certain Other Benefits.
	While the Company employs Executive during the Term,
	Executive shall be entitled to participate in any and all employee benefit plans and arrangements
	which are available to senior executive officers of the Company, including without limitation,
	group medical, disability and life insurance plans, and Companys Directors and Officers (D&O)
	insurance policy. Executive shall also be afforded no fewer than twenty-three (23) days paid time
	off (PTO) pursuant to policies fixed by the Company.
	     e. 
	Expenses.
	Subject to reasonable documentation and in accordance with the Companys
	business expense reimbursement policy, (i) the Company shall pay or reimburse Executive for all
	reasonable business expenses actually paid or incurred by Executive while Executive is employed by
	the Company during the Term, and (ii) the Company will reimburse Executive for up to $5,000 per
	year for professional fees, professional development and required continuing legal education
	courses during her employment.
	4.
	Term.
	The term of this Agreement shall be the period commencing on June 1, 2006 and continuing for one
	year (the Initial Term); provided, however, that the Term of this Agreement shall be extended
	automatically for successive one-year periods (each one-year extension a Successor Term and
	together with the Initial Term referred to herein as the Term) unless written notice of
	nonextension is provided by either party to the other party at least sixty (60) days prior to the
	end of the Initial Term or any Successor Term. In the event that this Agreement is not extended at
	the end of the Initial Term or any Successor Term and thereby terminates, only paragraphs 6, 7,
	8(d), 8(g), 8(h), 8(i) and 11 shall survive such termination, except that Executive shall be
	entitled to receive compensation and benefits to the extent expressly provided herein or by the
	terms of any of the Companys compensation and benefit plans, programs or policies or as required
	by applicable law.
	5.
	Stock Options.
	In connection with the Executives acceptance of employment, the Company will grant stock options
	to Executive covering 100,000 shares of common stock with a per share exercise price
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	equal to the closing price of EntreMeds stock on the date of grant. Such options will vest as to
	25% of the covered shares on the date of grant, and shall vest as to the remaining covered shares
	in cumulative 25% share increments on each of the first, second, and third anniversary of the date
	of grant, if Executive is then employed by the Company. Other periodic stock and incentive stock
	option grants to Executive, if any, while the Company employs Executive during the Term shall be
	determined by the Board or a committee thereof in its discretion. In the event of a termination
	pursuant to paragraph 8(d) hereof or a resignation pursuant to paragraph 9 hereof, for which
	purposes sections 10(a) and 10(c) of this Agreement shall control, all vested options held by
	Executive on the effective date of such termination or resignation shall be exercisable in
	accordance with the terms of such grants until the later of the date set forth in such grant or
	twelve (12) months following Executives date of termination, but in no event beyond the expiration
	date of the relevant option. Upon a change in control, as defined in the option agreement, all
	unvested options shall vest and become exercisable immediately in accordance with the terms of the
	option agreement. All other unvested options shall expire in accordance with the terms of such
	grants. Except as set forth herein, the terms of the stock option grants under this paragraph 5
	shall be otherwise in accordance with and subject to the terms of the Companys 2001 Long Term
	Incentive Plan or successor plan and such terms and conditions as the Board or a committee thereof
	may specify.
	6.
	Unauthorized Disclosure.
	During the Term and at all times thereafter, Executive shall not, without the written consent of
	the Company, or except as required by applicable law, disclose to any person, other than a person
	to whom disclosure is reasonably necessary or appropriate in connection with the performance by
	Executive of her duties as an executive officer of the Company, any material confidential
	information obtained by Executive while in the employ of the Company with respect to the businesses
	of the Company or any of its subsidiaries, including but not limited to, operations, pricing,
	contractual or personnel data, products, discoveries, improvements, trade secrets, license
	agreements, marketing information, suppliers, dealers, principles, customers, or methods of
	distribution, or any other confidential information the disclosure of which Executive knows, or in
	the exercise of reasonable care should know, will be damaging to the Company; provided, however,
	that confidential information shall not include any information known generally to the public or to
	persons in the industry of which the Companys business is a part (in each case, other than as a
	result of unauthorized disclosure by Executive) or any information otherwise considered by the
	Company not to be confidential.
	7.
	Indemnification.
	     a. The Company shall defend, indemnify and hold harmless Executive if she is made a party, or
	threatened to be made a party, to any threatened, pending or completed action, suit or proceeding,
	whether civil, criminal, administrative, or investigative (a Proceeding), because she is or was
	an officer or director of the Company or any of its subsidiaries, affiliates, or successors, or
	because she is or was serving in a fiduciary capacity with respect to employee benefit plans of the
	Company, whether or not the basis of such Proceeding is alleged action in an official capacity or
	otherwise, against all Expenses incurred or suffered by her in connection with such Proceeding to
	the fullest extent authorized by the General Corporation Law of the State of Delaware and any other
	applicable law in effect from time to time, and such indemnification
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	shall continue as to Executive even if she ceases to be an officer or director or is no longer
	employed by the Company, and shall inure to the benefit of Executives heirs, executors and
	administrators.
	     b. As used in this Agreement, the term Expenses shall include, without limitation, damages,
	losses, judgments, liabilities, fines, penalties, excise taxes, settlements and reasonable costs,
	reasonable attorneys fees, reasonable accountants fees, and reasonable disbursements and costs of
	attachment or similar bonds, investigations, and any reasonable expenses of establishing a right to
	indemnification under this Agreement.
	     c. Expenses incurred by Executive in connection with any Proceeding shall be paid by the
	Company upon presentation of appropriate documentation and a giving by Executive of any
	undertakings required by applicable law.
	8.
	Termination.
	     a. 
	Upon Death.
	If Executive dies while employed by the Company during the Term, her
	estate shall be entitled to receive payment of Base Salary through the last day of the six (6)
	months following the month in which her death occurred, payable over six (6) months at the
	Companys normal pay periods. If, in respect of the fiscal year in which Executive dies the Board
	or a committee thereof determines in its discretion that she would otherwise have been entitled to
	receive Incentive Compensation under subparagraph 3(c) by reason of the operations of the Company
	during such fiscal year, Executives estate shall be entitled to receive a pro rata portion of his
	Incentive Compensation for such fiscal year. Such pro rata portion shall equal the product of (x)
	the full amount of such Incentive Compensation, and (y) a fraction, the numerator of which is the
	number of days in the fiscal year of Executives death prior to the date of death, and the
	denominator of which is the total number of days in such fiscal year.
	     b. 
	Termination Upon Disability.
	The Company may terminate Executives employment
	hereunder during the Term at the end of any calendar month in the event of her Disability by giving
	to Executive written notice of termination. In the event of any such termination pursuant to this
	subparagraph 8(b), Executive shall be entitled to receive her Base Salary, payable in accordance
	with the Companys customary payroll policy for its executives, through the last day of the six (6)
	months following the month in which the date of termination occurred. If in respect of the fiscal
	year in which Executives employment terminates pursuant to this subparagraph 8(b) the Board or a
	committee thereof determines in its discretion that she would otherwise have been entitled to
	receive Incentive Compensation under subparagraph 3(c) by reason of the operations of the Company
	during such fiscal year, Executive shall be entitled to receive a pro rata portion of his Incentive
	Compensation for such year. Such pro rata portion shall equal the product of (x) the full amount
	of such Incentive Compensation, and (y) a fraction, the numerator of which is the number of days in
	the fiscal year of Executives termination on account of Disability prior to the date of
	termination, and the denominator of which is the total number of days in such fiscal year.
	     c. 
	Termination for Cause.
	The Company may terminate Executives employment hereunder
	at any time during the Term for Cause by giving to Executive written notice of termination that
	specifies the reasons for and date of termination, subject to the terms of sub-
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	paragraph 10(a) hereunder. Upon any such termination for Cause under this subparagraph 8(c),
	the Company shall pay to Executive Base Salary through the date of termination, including the
	benefits provided at paragraph 3(d), and the Company shall have no further obligations under this
	Agreement.
	     d. 
	Termination Without Cause.
	The Company may terminate Executives employment with
	the Company at any time during the Term, for any reason and without Cause, by giving her written
	notice thirty (30) days prior to the date of termination. Until the effective date of any such
	termination, the Company shall continue to pay to Executive the full compensation specified in this
	Agreement, including the benefits provided at paragraph 3(d). Following the date of termination,
	Executive shall make herself reasonably available to members of the Board, the CEO, and other
	senior managers and officers of the Company to assist in the transition of responsibilities and
	information to others and to facilitate the orderly conduct of business operations. Upon
	termination, the Company shall have no other financial obligations to Executive under any
	compensation or benefit plan, program or policy and Executives participation in the Companys
	compensation and benefit plans, programs and policies shall cease as of the date of Executives
	termination except as set forth herein or as expressly provided under the terms of any such plans,
	programs or policies, or as required by applicable law. However, in addition to the above, if
	Executive is terminated pursuant to this subparagraph 8(d), the Company shall (i) pay Executive a
	severance amount equal to six (6) months Base Salary over the following six (6) months at the
	Companys normal pay periods, and (ii) provide Executive coverage under the Companys health
	insurance program, under the same terms as are available to other senior executive officers of the
	Company, for a period of six (6) months, after which Executive would be eligible for COBRA
	continuation coverage, or until she has obtained substantially equivalent new coverage, as
	determined by the Board or a committee thereof in its discretion, through successor employment,
	whichever occurs sooner. If, in respect of the fiscal year in which Executives employment
	terminates pursuant to this subparagraph 8(d), the Board or a committee thereof determines in its
	discretion that she would otherwise have been entitled to receive Incentive Compensation under
	subparagraph 3(c) by reason of the operations of the Company during such fiscal year, Executive
	shall be entitled to receive a pro rata portion of her Incentive Compensation for such year. Such
	pro rata portion shall equal the product of (x) the full amount of such Incentive Compensation, and
	(y) a fraction, the numerator of which is the number of days in the fiscal year of Executives
	termination without Cause prior to the date of termination, and the denominator of which is the
	total number of days in such fiscal year.
	     e. 
	Resignation for Other than Good Reason.
	Executive may voluntarily terminate her
	employment with the Company during the Term for any reason upon at least thirty (30) days prior
	written notice, which specifies the effective date of termination. Until the effective date of
	such termination, the Company shall continue to pay her the full compensation specified in this
	Agreement, including the benefits provided at paragraph 3(d), provided she continues to perform her
	duties during this period. Thereafter, the Company shall have no further obligations to her under
	this Agreement. This subparagraph 8(e) shall not apply to Executives resignation for Good Reason
	pursuant to paragraph 9 hereof.
	     f. 
	No Mitigation
	. The parties hereto acknowledge and agree that, in the event
	Executives employment with the Company is terminated pursuant to this paragraph 8, she shall not
	be required to mitigate her damages by affirmatively seeking other employment. Further,
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	except as provided in subparagraph 8(d)(ii) above, the amount of any payment or benefit provided
	for in this Agreement shall not be reduced by any compensation earned by her or benefit provided to
	her as the result of employment by another employer or otherwise.
	     g. 
	Non-Competition
	. For a period of 1) twelve (12) months after resignation for other
	than for Good Reason or 2) six (6) months after termination of employment with the Company for any
	other reason, Executive shall not, as an individual, principal, agent, employee, consultant or
	otherwise, directly or indirectly, or with respect to any company or entity with which the Company
	has concluded partnership, licensing, joint research and development or other similar business
	agreements during his employment with the Company, render any services to any firm or company or
	any division or subsidiary of any firm or company, engaged in the development or commercialization
	of compounds, analogs or derivatives of those compounds that (a) are of a similar type, that is,
	small molecules, (for example, but not limited to, small peptidomimetic molecules), (b) have more
	than one mechanism of action and cellular pathway in common with; and (c) are within the same field
	(
	i
	.
	e
	. oncology or inflammation) as, those being developed and or commercialized by
	the Company during the Term (Competing Company). In addition, for an additional period of six
	(6) months after the six-month period set forth above and subject to Section 6 hereof, Executive
	only may provide services to such a Competing Company if Executive does not work on, or furnish
	confidential information regarding, any matter related to such compounds defined above. Moreover,
	for a period of twelve (12) months after the termination of Executives employment with the
	Company, Executive shall not take any action, without the prior written consent of the Company, to
	assist Executives successor employer or any other entity in recruiting or hiring any other
	employee who was an employee of the Company during Executives employment. This prohibition
	includes (i) identifying to such successor employer or its agents or such other entity, the person
	or persons who have special knowledge concerning the Company or its inventions, processes, methods
	or confidential affairs, and (ii) commenting to Executives successor employer or its agents or
	such other entity about the quantity or work, quality of work, special knowledge or personal
	characteristics of any person who is still employed by the Company. Executive also agrees that she
	will not provide such information to a prospective employer or to an executive search firm during
	interviews preceding possible employment.
	     h. 
	Non-Disparagement
	. During the Term and thereafter, Executive shall not communicate
	negatively about or otherwise disparage the Company or its products or each and any of the released
	parties described in subparagraph 8(i) in any way whatsoever except as may be required for truthful
	sworn testimony or in connection with a legal or administrative proceeding, report, claim or
	dispute. The Company, acting in its official capacity, shall not make any public false, disparaging
	or derogatory statements in connection with or concerning Executives service to the Company except
	as may be required for truthful sworn testimony or in connection with a legal or administrative
	proceeding, report, claim or dispute. After termination, in the event Executive materially breaches
	any of the conditions set forth herein or in any other paragraph of this Agreement, the Company may
	discontinue the provision of any payment or benefits to her under this Agreement, and in such event
	she shall forfeit her entitlement to any further termination payments or benefits under this
	Agreement. After termination, in the event the Company materially breaches any of the conditions
	set forth herein or in any other paragraph of this Agreement, the Executive may pursue any remedies
	available to her at law.
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	     i. 
	Release
	. In consideration of Executives receipt of severance benefits subject to
	and in accordance with subparagraphs 8(b) and (d) and paragraph 9 of this Agreement, Executive
	agrees that, upon her first receipt and acceptance of any such benefits, she shall have released
	and forever discharged the Company, its subsidiaries and affiliates, successors and assigns,
	predecessors and all of their respective officers, directors, employees and agents and employee
	benefits plans from all claims, demands, liabilities and causes of action arising out of facts or
	occurrences arising or occurring at any time up to and including the time of Executives
	termination or resignation, whether known or unknown, and the parties hereto contemplate that this
	release shall be broadly construed.
	9.
	Resignation for Good Reason.
	If Executive has Good Reason during the Term, Executive may resign at any time during the Term by
	providing at least thirty (30) days prior written notice to the Company that specifies the reason
	for, and the effective date of, her resignation. If Executive resigns during the Term for Good
	Reason, such resignation shall be deemed a Termination without Cause under subparagraph 8(d) hereof
	and Executive shall receive the compensation and benefits provided under subparagraph 8(d) hereof
	as if she had been terminated without Cause.
	10.
	Definitions.
	      a. Cause shall mean Executives (i) habitual drunkenness or drug addiction, (ii) material
	failure to perform and discharge her duties and responsibilities hereunder, (iii) misconduct that
	is materially and significantly injurious to the Company, (iv) conviction of a felony involving the
	personal dishonesty of Executive or moral turpitude, (v) conviction of any crime or offense
	involving the property of the Company or (vi) material breach of Executives obligations under this
	Agreement; provided, however, with regard to a.(ii) and a.(vi.) above, the parties exclude for
	this purpose an action not taken in bad faith that is remedied by Executive promptly upon receipt
	of written notice thereof given to the Company.
	      b. Disability shall mean the Executives incapacity due to physical or mental illness which
	prevents the proper performance of Executives duties as set forth herein or established pursuant
	hereto for ninety (90) days in any twelve (12) month period of the Term. A qualified independent
	physician mutually selected by the Company and the Executive shall determine any questions as to
	the existence or extent of illness or incapacity of Executive, upon which the Company and Executive
	cannot agree. The determination of such physician certified in writing to the Company and to the
	Executive shall be final and conclusive for all purposes of this Agreement. For purposes of the
	disability provisions of this Agreement, if the Executive is unable to act on her own behalf due to
	incapacity, any person legally authorized to do so may act on the Executives behalf.
	      c. Good Reason shall mean the occurrence of any of the following events during the Term:
	(i) the assignment to Executive of any duties inconsistent in any material respect with Executives
	position, authority, duties or responsibilities as of the commencement of the Term or any other
	action by the Company which results in a diminution in any material respect in such position,
	duties or responsibilities, excluding for this purpose an isolated and inadvertent action not taken
	in bad faith that is remedied by the Company promptly after receipt of written notice
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	thereof given by Executive; (ii) a reduction by the Company in Executives annual Base Salary
	as in effect on the date hereof or subsequently in effect hereunder, except as agreed to by
	Executive; (iii) the failure by the Company to continue to provide Executive with benefits
	substantially similar to those enjoyed by her under any of the Companys pension, life insurance,
	medical, health and accident, disability or other welfare plans in which she was participating as
	of the commencement of the Term or subsequently in effect hereunder, unless such change was
	applicable to all senior executives of the Company; (iv) the failure by the Company to pay to
	Executive any deferred compensation when due under any deferred compensation plan or agreement
	applicable to her; (v) the failure by the Company to honor in any material respect the terms and
	provisions of this Agreement; or (vi) a requirement by the Company that Executive conduct her
	duties and responsibilities from a permanent location more than fifty (50) miles from the place of
	employment, as defined in paragraph 2 herein.
	11.
	Miscellaneous.
	     a. 
	Assignments and Binding Effect.
	The respective rights and obligations of the
	parties under this Agreement shall be binding upon the parties hereto and their heirs, executors,
	administrators, successors, and assigns, including, in the case of the Company, any other
	corporation or entity with which the Company may be merged or otherwise combined and, in the case
	of Executive, her estate or other legal representatives.
	     b. 
	No Assignment of Benefits.
	Except as otherwise provided herein or by applicable
	law, no right or interest of the Executive under this Agreement shall be assignable or
	transferable, in whole or in part, either directly or by the operation of law or otherwise,
	including without limitation execution, levy, garnishment, attachment, pledge or in any manner; no
	attempted transfer thereof shall be effective.
	     c. 
	Governing Law.
	This Agreement shall be governed as to its validity, interpretation
	and effect by the laws of the State of Maryland, without reference to its conflict of laws
	provisions.
	     d. 
	Severability.
	In the event that any provision or portion of this Agreement shall
	be determined to be invalid, illegal, or unenforceable for any reason, the remaining provisions and
	portions of this Agreement shall remain in full force and effect to the fullest extent permitted by
	law. Such invalid, illegal or unenforceable provision(s) shall be deemed modified to the extent
	necessary to make it (or them) valid, legal, and enforceable.
	     e. 
	Withholding.
	All amounts payable hereunder shall be paid net of any applicable
	withholding required under federal, state or local laws and any additional withholding to which
	Executive has agreed.
	     f. 
	Entire Agreement; Amendments.
	This Agreement constitutes the entire Agreement and
	understanding of the Company and Executive with respect to the terms of Executives employment with
	the Company and supersedes all prior discussions, understandings and agreements with respect
	thereto.
	     g. 
	Captions.
	All captions and headings used herein are for convenient reference only
	and do not form part of this Agreement.
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	     h. 
	Waiver.
	No provision of this Agreement may be modified, waived or discharged
	unless such modification, waiver or discharge is agreed to in writing and signed by the Executive
	and the Board or its delegate. The failure of the Company or the Executive to insist upon strict
	compliance with the terms of this Agreement or the failure of the Company or the Executive to
	assert any right the Company or the Executive may have hereunder shall not be deemed a waiver of
	such provision or right or any other provision of this Agreement.
	     f. 
	Notice.
	Any notice or communication required or permitted under this Agreement
	shall be made in writing and shall be delivered by hand, or mailed by registered or certified mail,
	return receipt requested, first call postage prepaid, addressed as follows:
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	If to Executive:
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	      Cynthia Wong
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	      c/o EntreMed, Inc.
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	      9640 Medical Center Drive
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	      Rockville, Maryland 20850
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	If to the Company:
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	      EntreMed, Inc.
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	      9640 Medical Center Dive
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	      Rockville, Maryland 20850
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	      Attn.: Chief Executive Officer
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	     g. 
	Counterparts.
	This Agreement may be executed in counterparts, each of which shall
	constitute one and the same agreement.
	[SIGNATURE PAGE FOLLOWS]
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	     IN WITNESS WHEREOF, the parties hereto have executed this Agreement effective as of June 1,
	2006.
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	/s/ Cynthia Wong
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	Cynthia Wong
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	Executive
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	EntreMed, Inc.
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	By:
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	/s/ James S. Burns
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	James S. Burns
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	President and Chief Executive Officer
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