U.S. SECURITIES AND EXCHANGE COMMISSION
Washington, D. C. 20549


FORM 8-A

FOR REGISTRATION OF CERTAIN CLASSES OF SECURITIES
PURSUANT TO SECTION 12(b) or 12(g) OF THE
SECURITIES EXCHANGE ACT OF 1934


ARQULE, INC.
(Exact name of Registrant as Specified in its Charter)

             DELAWARE                                  04-3221586
- ----------------------------------------   ------------------------------------
(State of Incorporation or Organization)   (I.R.S. Employer Identification No.)


              200 BOSTON AVENUE, MEDFORD, MASSACHUSETTS                02155
              -----------------------------------------              ----------
              (Address of Principal Executive Offices)               (Zip Code)


If this Form relates to the         If this Form relates to the registration
registration of a class of debt     of a class of debt securities and is to
securities and is effective upon    become effective simultaneously with the
filing pursuant to General          effectiveness of a concurrent
Instruction A(c)(1) please check    registration statement under the
the following box. / /              Securities Act of 1933 pursuant to
                                    General Instruction A(c)(2) please check
                                    the following box. / /

SECURITIES TO BE REGISTERED PURSUANT TO SECTION 12(b) OF THE ACT:

Title of Each Class                   Name of Each Exchange on Which
to be so Registered                   Each Class is to be Registered
-------------------                   ------------------------------

      None                                         None
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SECURITIES TO BE REGISTERED PURSUANT TO SECTION 12(g) OF THE ACT:

COMMON STOCK, $0.01 PAR VALUE PER SHARE
(Title of Class)

INFORMATION REQUIRED IN REGISTRATION STATEMENT

ITEM 1. DESCRIPTION OF REGISTRANT'S SECURITIES TO BE REGISTERED.

The description of the shares of Common Stock of ArQule, Inc. (the "Registrant") registered hereby is contained under the caption "Description of Capital Stock" on page 40 of the Registrant's Registration Statement on Form S-1 initially filed with the Securities and Exchange Commission on August 29, 1996 and amended on September 24, 1996 (Commission File No. 333-11105), under the Securities Act of 1933, as amended, and is hereby incorporated by reference.

ITEM 2. EXHIBITS.

1. Amended and Restated Certificate of Incorporation of the Registrant, as amended through the date hereof. Filed as Exhibit 3.1 to the Registrant's Registration Statement on Form S-1 and hereby incorporated by reference.

2. Form of Certificate of Amendment to the Amended and Restated Certificate of Incorporation as proposed to be filed upon effectiveness of the Registrant's Registration Statement. Filed as Exhibit 3.2 to the Registrant's Registration Statement on Form S-1 and hereby incorporated by reference.

3. Form of Amended and Restated Certificate of Incorporation of the Registrant as proposed to be amended concurrently with the closing of this offering. Filed as Exhibit 3.3 to the Registrant's Registration Statement on Form S-1 and hereby incorporated by reference.

4. By-laws of the Registrant. Filed as Exhibit 3.4 to the Registrant's Registration Statement on Form S-1 and hereby incorporated by reference.

5. Amended and Restated By-Laws of the Registrant as proposed to be amended concurrently with the closing of this offering. Filed as Exhibit 3.5 to the Registrant's Registration Statement on Form S-1 and hereby incorporated by reference.

6. Specimen Common Stock Certificate, $0.01 par value per share, of the Registrant. Filed as Exhibit 4.1 to the Registrant's Registration Statement on Form S-1 and hereby incorporated by reference.

7. Specimen Common Stock Purchase Warrant of the Registrant. Filed as Exhibit 4.2 to the Registrant's Registration Statement on Form S-1 and hereby incorporated by reference.

8. 1994 Amended and Restated Equity Incentive Plan of the Registrant, as amended through October 17, 1994. Filed as Exhibit 10.1 to the Registrant's Registration Statement on Form S-1 and hereby incorporated by reference.

9. 1996 Employee Stock Purchase Plan of the Registrant. Filed as Exhibit 10.2 to the Registrant's Registration Statement on Form S-1 and hereby incorporated by reference.

10. 1996 Director Stock Option Plan of the Registrant. Filed as Exhibit 10.3 to the Registrant's Registration Statement on Form S-1 and hereby incorporated by reference.

11. Investors' Rights Agreement among the Registrant and certain Stockholders of the Registrant dated November 2, 1995. Filed as Exhibit 10.5 to the Registrant's Registration Statement on Form S-1 and hereby incorporated by reference.

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SIGNATURE

Pursuant to the requirements of Section 12 of the Securities Exchange Act of 1934, the Registrant has duly caused this registration statement to be signed on its behalf by the undersigned, thereunto duly authorized.

ARQULE, INC.

Date:  September 24, 1996                By: /s/ Eric B. Gordon
                                           ----------------------------------
                                         Name:  Eric B. Gordon
                                         Title: President and Chief Executive
                                                Officer

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