SECURITIES AND EXCHANGE COMMISSION
WASHINGTON, D.C. 20549


FORM 8-A

FOR REGISTRATION OF CERTAIN CLASSES OF SECURITIES
PURSUANT TO SECTION 12(b) OR (g) OF THE
SECURITIES EXCHANGE ACT OF 1934

SANGAMO BIOSCIENCES, INC.

(Exact Name of Registrant as Specified in Its Charter)

               DELAWARE                                  68-0359556
      --------------------------                     ------------------
      (State of Incorporation or                      (I.R.S. Employer
            Organization)                            Identification No.)

501 CANAL BOULEVARD, SUITE A200, RICHMOND, CA               94804
---------------------------------------------             ---------
  (Address of principal executive offices)                (Zip Code)

      If this form relates to the                If this form relates to the
      registration of a class of                 registration of a class of
      securities pursuant to                     securities pursuant to
      Section 12(b) of the Exchange              Section 12(g) of the Exchange
      Act and is effective pursuant              Act and is effective pursuant
      to General Instruction A.(c),              to General Instruction A.(d),
      please check the following                 please check the following
      box. [ ]                                   box. [X]

Securities Act registration statement file number to which this form relates:
333-30134
(If applicable)

Securities to be registered pursuant to Section 12(b) of the Act:

      Title of Each Class                     Name of Each Exchange on Which
      to be so Registered                     Each Class is to be Registered
      -------------------                     ------------------------------

-------------------------------------     -------------------------------------

-------------------------------------     -------------------------------------

Securities to be registered pursuant to Section 12(g) of the Act:

COMMON STOCK, $0.01 PAR VALUE

(Title of Class)


(Title of Class)

1

Item 1. Description of Registrant's Securities to be Registered.

Incorporated herein by reference to the Description of Capital Stock section of the Company's Registration Statement on Form S-1 (File No. 333-30134) (the "Registration Statement"), as originally filed on February 11, 2000, or as subsequently amended.

Item 2. Exhibits.

Exhibit
Number      Description
------      -----------
  3.1       Amended and Restated Certificate of Incorporation of the Registrant,
            as filed with the Delaware Secretary of State is incorporated herein
            by reference to Exhibit 3.1 to Amendment No. 1 to the Company's
            Registration Statement on Form S-1 (File No. 333-30134).

  3.2       Amended and Restated Bylaws of the Registrant are incorporated
            herein by reference to Exhibit 3.2 to Amendment No. 1 to the
            Company's Registration Statement on Form S-1 (File No. 333-30134).

  4.1       Form of Registrant's Specimen Common Stock Certificate.

2

SIGNATURE

Pursuant to the requirements of Section 12 of the Securities Exchange Act of 1934, the registrant has duly caused this registration statement to be signed on its behalf by the undersigned, there-to duly authorized.

SANGAMO BIOSCIENCES, INC.

Date:  March 29, 2000                     By:  /s/ Shawn K. Johnson
                                               ----------------------
                                               Shawn K. Johnson
                                               Director of Finance

3

EXHIBIT INDEX

Exhibit
Number      Description
------      -----------
  3.1       Amended and Restated Certificate of Incorporation of the Registrant,
            as filed with the Delaware Secretary of State is incorporated herein
            by reference to Exhibit 3.1 to Amendment No. 1 to the Company's
            Registration Statement on Form S-1 (File No. 333-30134).

  3.2       Amended and Restated Bylaws of the Registrant are incorporated
            herein by reference to Exhibit 3.2 to Amendment No. 1 to the
            Company's Registration Statement on Form S-1 (File No. 333-30134).

  4.1       Form of Registrant's Specimen Common Stock Certificate.




SANGAMO BIOSCIENCES, INC.

INCORPORATED IN THE STATE OF DELAWARE

COMMON SHARES COMMON SHARES

THIS CERTIFICATE IS TRANSFERABLE CUSIP 80677 10 6
IN BOSTON, MA AND NEW YORK, NY SEE REVERSE FOR CERTAIN DEFINITIONS

This certifies that

is the recordholder of

FULLY PAID AND NONASSESSABLE SHARES OF THE COMMON STOCK,
PAR VALUE $0.01 PER SHARE of

Sangamo BioSciences, Inc. transferable on the books of the Corporation by the holder hereof in person or by duly authorized Attorney upon surrender of this Certificate properly endorsed. This Certificate is not valid until countersigned and registered by the Transfer Agent and Registrar.

/s/ Shawn Johnson                                     /s/ Edward O. Lanphier
      Secretary                        President and Chief Executive Officer

Countersigned and Registered
EQUISERVE TRUST COMPANY, N.A.

By: [illegible]

Authorized Signature

SANGAMO BIOSCIENCES, INC.

Upon request the Corporation will furnish any holder of shares of Common Stock of the Corporation, without charge, with a full statement of the powers, designations, preferences, and relative, participating, optional or other special rights of any class or series of capital stock of this Corporation, and the qualifications, limitations or restrictions of such preferences and/or rights.

The following abbreviations, when used in the inscription on the face of this certificate, shall be construed as though they were written out in full according to applicable laws or regulations:

TEN COM -- as tenants in common
TEN ENT -- as tenants by the entireties
JT TEN -- as joint tenants with right of survivorship and not as tenants in common

UNIF GIFT MIN ACT --                            Custodian
                     --------------------------           ----------------------
                             (cust)                              (minor)
                     under Uniform Gift to Minor
                     Act
                         -----------------------
                                (state)

Additional abbreviations may also be used although not in the above item.

For Value received, ___________________________ hereby sell, assign and transfer unto
PLEASE INSERT SOCIAL SECURITY OR OTHER
IDENTIFYING NUMBER OF ASSIGNEE


(PLEASE PRINT OR TYPEWRITE THE NAME AND ADDRESS, INCLUDING ZIP CODE OF ASSIGNEE)

_________________________________________________________________________ Shares

of Common Stock represented by the within Certificate, and to hereby irrevocably constitute and appoint
_______________________________________________________________________ Attorney to transfer the said stock on the books of the within named Corporation with full power of substitution in the premises.

Dated ____________________

In presence of

X _______________________________   X ________________________________
                                          THE SIGNATURE TO THE ASSIGMENT
                                          MUST CORRESPOND WITH THE NAME AS
                                  NOTICE: WRITTEN UPON THE FACE OF THE
                                          CERTIFICATE IN EVERY PARTICULAR,
                                          WITHOUT ALTERATION OR ENLARGEMENT OR
                                          ANY CHANGE WHATEVER.


Signature(s) Guaranteed

By ______________________________
THE SIGNATURE(S) MUST BE GUARANTEED BY AN ELIGIBLE GUARANTOR INSTITUTION (BANK, STOCKBROKER, SAVINGS AND LOAN ASSOCIATION AND CREDIT UNION WITH MEMBERSHIP IN AN APPROVED SIGNATURE GUARANTEE MEDALLION PROGRAM),

PURSUANT TO SEC RULE 17 AND 18.