As filed with the Securities and Exchange Commission on October 9, 2007 File No. 333-
   

SECURITIES AND EXCHANGE COMMISSION
WASHINGTON, D.C. 20549

FORM S-8
REGISTRATION STATEMENT
UNDER THE SECURITIES ACT OF 1933

MEDICURE INC.
(Exact name of registrant as specified in its charter)

Canada Not Applicable
(State or other jurisdiction of Incorporation or (I.R.S. Employer Identification No.)
organization)  

4-1200 Waverley Street
Winnipeg, MB Canada R3T 0P4
(Address of Principal Executive Offices, including zip code)

STOCK OPTION PLAN AMENDED AND RESTATED OCTOBER 2, 2007

(Full title of the plan)

Dorsey & Whitney LLP
U.S. Bank Centre
1420 Fifth Avenue
Suite 3400
Seattle, WA 98101-4010
(206) 903-2423
(Telephone number, including area code, of agent for service)
Copies to:
Brahmy Poologasingham
Dorsey & Whitney LLP
U.S. Bank Centre
1420 Fifth Avenue, Suite 3400
Seattle, WA 98101-4010
(206) 903-8875

CALCULATION OF REGISTRATION FEE

Title of Each Class of
Securities to be Registered
Amount to
be Registered (1)
Proposed Maximum Offering Price
Per Share
Proposed Maximum Aggregate
Offering Price
Amount of
Registration Fee (2)
Common Shares issuable
pursuant to the options
outstanding under the Medicure
Stock Option Plan
Additional Medicure Common
Shares reserved for issuance
pursuant to the Medicure Stock
Option Plan

3,985,528



9,045,227


$1.29 (2)



$1.13 (3)


$5,141,331.12 (2)



10,221,106.51 (3)


$158.00



$314.00


(1)

Common Shares, without par value, offered by Medicure Inc. (the “Registrant”) pursuant to the plan described therein.

(2)

Estimated solely for the purpose of calculating the registration fee in accordance with Rule 457(h) under the Securities Act of 1933, as amended. Canadian figures have been converted at the applicable noon buying rate as provided by the Federal Reserve Bank of New York on the date granted, unless that date was a weekend or holiday, in which case by the date immediately preceding that weekend or holiday. The maximum aggregate offering price is based upon the aggregate exercise price of outstanding options.

(3)

The proposed maximum offering price per share and the registration fee were calculated in accordance with rule 457(c) and (h) based on the average high and low prices for the Registrant’s common shares on October 2, 2007, as quoted on the American Stock Exchange, which was $ 1.13 per share.

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INTRODUCTORY STATEMENT

     This registration statement on Form S-8 registers 13,030,755 common shares (“Common Shares”) of Medicure Inc. (the “Registrant”) reserved for issuance upon the exercise of stock options granted under the Stock Option Plan Amended and Restated October 2, 2007 of the Registrant (the “Stock Option Plan”) .

     If a stock option issued under the Stock Option Plan expires or terminates for any reason without having been exercised in full, the unpurchased Common Shares shall be again available for the purposes of the Plan.

     Pursuant to Rule 416(a) of the United States Securities Act of 1933, as amended (the “Securities Act”) this registration statement also covers any additional securities that may be offered or issued to prevent dilution resulting from stock splits, stock dividends or similar transactions.

PART I. INFORMATION REQUIRED IN THE SECTION 10(A) PROSPECTUS

Item 1. Plan Information. *

Item 2. Registrant Information and Employee Plan Annual Information. *

     * This information is not required to be included in, and is not incorporated by reference in, this registration statement.

PART II. INFORMATION REQUIRED IN THE REGISTRATION STATEMENT

Item 3. Incorporation of Documents by Reference.

     The following documents filed or furnished by the Registrant with or to the Securities and Exchange Commission (the “Commission”) are hereby incorporated by reference in this registration statement:

  (a)

The Registrant’s Annual Report on Form 20-F (File No. 001-31995) for the fiscal year ended May 31, 2007 filed with the Commission on August 27, 2007;

     
  (b)

All other reports of the Registrant filed pursuant to Section 13(a) or 15(d) of the United States Securities Exchange Act of 1934, as amended (the “Exchange Act”), since the end of the fiscal year covered by the annual report incorporated by reference herein pursuant to (a) above; and

     
  (c)

The description of the Registrant’s securities contained in the Registrant’s amended Registration Statement on Form 8-A filed under the Exchange Act on February 12, 2004, and any amendment or report filed for the purpose of updating such description.

     All documents subsequently filed by the Registrant pursuant to Sections 13(a), 13(c), 14 and 15(d) of the Exchange Act prior to the filing of a post-effective amendment that indicate that all securities offered have been sold or which deregisters all securities then remaining unsold, shall be deemed to be incorporated by reference into this registration statement and to be a part hereof from the date of filing of such documents. Any statement contained in a document incorporated or deemed to be incorporated by reference herein shall be deemed to be modified or superseded for the purposes of this registration statement to the extent that a statement contained herein or in any other subsequently filed document which also is or is deemed to be incorporated by reference herein modifies or supersedes such statement. Any statement so modified or superseded shall not be deemed, except as so modified or superseded, to constitute a part of this registration statement.

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Item 4. Description of Securities.

     Not Applicable.

Item 5. Interests of Named Experts and Counsel.

     None.

Item 6. Indemnification of Directors and Officers.

     Applicable Laws of Canada

     Section 124 of the Canada Business Corporations Act (the “CBCA”) provides that a corporation may indemnify a present or former director or officer of the corporation, or another individual who acts or acted at the corporation’s request as a director or officer, or an individual acting in a similar capacity, of another entity, against all costs, charges and expenses, including an amount paid to settle an action or satisfy a judgment, reasonably incurred by the individual in respect of any civil, criminal, administrative, investigative or other proceeding in which the individual is involved because of that association with the corporation or other entity, provided that the individual (a) acted honestly and in good faith with a view to the best interests of the corporation or, as the case may be, the other entity; and (b) in the case of a criminal or administrative action or proceeding that is enforced by a monetary penalty, had reasonable grounds for believing that the individual’s conduct was lawful. Furthermore, a corporation may advance moneys to a director, officer or other individual for the costs, charges and expenses of a proceeding referred to above. The individual shall repay the moneys if the individual does not fulfill the conditions set out in subsection (a) and (b) above.

     Notwithstanding the above, an individual is entitled to indemnity from the corporation in respect of all costs, charges and expenses reasonably incurred by the individual in connection with the defense of any civil, criminal, administrative, investigative or other proceeding to which the individual is subject because of the individual’s association with the corporation or other entity as described above, if the individual seeking indemnity (a) was not judged by the court or other competent authority to have committed any fault or omitted to do anything that the individual ought to have done; (b) acted honestly and in good faith with a view to the best interests of the corporation, or, as the case may be, to the best interests of the other entity for which the individual acted as director or officer or in a similar capacity at the corporation’s request; and (c) in the case of a criminal or administrative action or proceeding that is enforced by a monetary penalty, had reasonable grounds for believing that the individual’s conduct was lawful.

     Bylaws

     Subject to the limitations contained in the CBCA, but without limiting the right of the Corporation to indemnify any individual under the CBCA or otherwise to the full extent permitted by law, the Corporation (a) shall indemnify each director or officer or former director or officer and each other individual who acts or has acted at the Corporation’s request as a director or officer, of a body corporate of which the corporation is or was a shareholder or creditor (and each such individual’s respective heirs and personal representatives), against all costs, charges and expenses, including an amount paid to settle an action or satisfy a judgment, reasonably incurred in respect of any civil, criminal, administrative, investigative or other proceeding in which the individual is involved because of that association with the Corporation or other person, provided (i) the individual acted honestly and in good faith with a view to the best interests of the Corporation, or, as the case may be, to the best interests of the other person for which the individual acted as a director or officer or in a similar capacity at the Corporation’s request; and (ii) in the case of a criminal or administrative action or proceeding that is enforced by a monetary penalty, the individual had reasonable grounds for believing that the individual’s conduct was lawful; and (b) may advance monies to a director, officer or other individual for the costs, charges and expenses of a proceeding referred to in Section (a) in accordance with the CBCA.

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     Notwithstanding the foregoing, any such indemnity or advance of monies in respect of an action referred to in Section (a) by or on behalf of at the request of the Corporation to procure judgment in its favour shall be subject to approval of a court.

     Insurance

     A policy of director’s and officers’ liability insurance is maintained by the Registrant which insures directors and officers for losses as a result of claims against the directors and officers of the Registrant in their capacity as directors and officers and also reimburses the Registrant for payments made pursuant to the indemnity provisions under the by-laws of the Registrant and the CBCA.

     Commission Position on Indemnification

     Insofar as indemnification for liabilities under the Securities Act may be permitted to directors, officers or persons controlling the Registrant pursuant to the foregoing provisions, the Registrant has been informed that in the opinion of the Commission such indemnification is against public policy in the United States as expressed in the Securities Act and is therefore unenforceable.

Item 7. Exemption from Registration Claimed.

     Not Applicable

Item 8. Exhibits.

Exhibit Number                                                                                                   Exhibit
4.1 Medicure Inc. Stock Option Plan Amended and Restated October 2, 2007
4.2 Form of Stock Option Agreement for Stock Option Plan
5.1 Opinion of Lang Michener LLP
23.1 Consent of KPMG LLP
23.5 Consent of Lang Michener LLP (contained in its opinion filed as Exhibit 5.1)
24.1 Power of Attorney (See page II-8 of this registration statement)

Item 9. Undertakings.

(a)

The undersigned Registrant hereby undertakes:

       
(1)

To file, during any period in which offers or sales are being made, a post-effective amendment to this registration statement:

       
(i)

To include any prospectus required by Section 10(a)(3) of the Securities Act;

       
(ii)

To reflect in the prospectus any facts or events arising after the effective date of the registration statement (or the most recent post-effective amendment thereof) which, individually or in the aggregate, represent fundamental changes in the information set forth in the registration statement. Notwithstanding the foregoing, any increase or decrease in volume of securities offered (if the total dollar value of securities offered would not exceed that which was registered) and any deviation from the low or high end of the estimated maximum offering range may be reflected in the form of prospectus filed with the Commission pursuant to Rule 424(b) if, in the aggregate, the change in volume and price represents no more than 20% change in the maximum aggregate offering price set forth in the “Calculation of Registration Fee” table in the effective registration statement;

II-5



  (iii)

To include any material information with respect to the plan of distribution not previously disclosed in the registration statement or any material change to such information in the registration statement;

       

provided, however, that paragraphs (a)(1)(i) and (a)(1)(ii) do not apply if the registration statement is on Form S-3, Form S-8, or Form F-3 and the information required to be included in a post-effective amendment by those paragraphs is contained in periodic reports filed with or furnished to the Commission by the Registrant pursuant to Section 13 or Section 15(d) of the Exchange Act that are incorporated by reference in this registration statement.

       
(2)

That for the purpose of determining any liability under the Securities Act, each such post-effective amendment shall be deemed to be a new registration statement relating to the securities offered therein, and the offering of such securities at that time shall be deemed to be the initial bona fide offering thereof.

       
(3)

To remove from registration by means of a post-effective amendment any of the securities being registered which remain unsold at the termination of the offering.

       
(b)

The undersigned Registrant hereby undertakes that, for purposes of determining any liability under the Securities Act, each filing of the Registrant's annual report pursuant to Section 13(a) or Section 15(d) of the Exchange Act, (and, where applicable, each filing of an employee benefit plan's annual report pursuant to section 15(d) of the Exchange Act) that is incorporated by reference in the registration statement shall be deemed to be a new registration statement relating to the securities offered therein, and the offering of such securities at that time shall be deemed to be the initial bona fide offering thereof.

   
(h)

Insofar as indemnification for liabilities arising under the Securities Act may be permitted to directors, officers and controlling persons of the Registrant pursuant to the foregoing provisions, or otherwise, the Registrant has been advised that in the opinion of the Commission such indemnification is against public policy as expressed in the Securities Act and is, therefore, unenforceable. In the event that a claim for indemnification against such liabilities (other than the payment by the Registrant of expenses incurred or paid by a director, officer or controlling person of the Registrant in the successful defense of any action, suit or proceeding) is asserted by such director, officer or controlling person in connection with the securities being registered, the Registrant will, unless in the opinion of its counsel the matter has been settled by controlling precedent, submit to a court of appropriate jurisdiction the question of whether such indemnification by it is against public policy as expressed in the Securities Act and will be governed by the final adjudication of such issue.

II-6


SIGNATURES

      The Registrant . Pursuant to the requirements of the Securities Act of 1933, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has duly caused this registration statement to be signed on its behalf by the undersigned, thereunto duly authorized in the City of Winnipeg on this 9th day of October, 2007.

  MEDICURE INC.
   
   
  /s/ Albert Friesen
  Name: Albert D. Friesen, Ph.D.
  Title: President and Chief Executive Officer

II-7


POWERS OF ATTORNEY

     Each person whose signature appears below constitutes and appoints Albert D. Friesen and Derek Reimer, or either one of them, his true and lawful attorney-in-fact and agent, with full power of substitution and resubstitution, for such person and in such person’s name, place and stead, in any and all capacities, to sign any and all amendments to this registration statement, and to file the same, with all exhibits thereto and other documents in connection therewith, with the Securities and Exchange Commission, granting unto said attorney-in-fact and agent full power and authority to do and perform each and every act and thing requisite and necessary to be done in and about the premises, as fully to all intents and purposes as he might or could do in person, hereby ratifying and confirming all that said attorney-in-fact and agent, or their substitute or substitutes, may lawfully do or cause to be done by virtue thereof.

     Pursuant to the requirements of the Securities Act of 1933, as amended, this registration statement has been signed by the following persons in the capacities and on the date indicated.

                            Signature   Title Date
       
       
/s/ Albert Friesen   President and Chief Executive Officer and Director October 9, 2007
Albert D. Friesen   (principal executive officer)  
       
       
/s/ Derek Reimer   Chief Financial Officer and Secretary October 9, 2007
Derek Reimer   (principal financial and accounting officer)  
       
       
/s/ Arnold Naimark   Director October 9, 2007
Arnold Naimark      
       
       
/s/ Gerald McDole   Director October 9, 2007
Gerald McDole      
       
       
/s/ Peter Quick   Director October 9, 2007
Peter Quick      
       

II-8


AUTHORIZED REPRESENTATIVE

     Pursuant to the requirements of Section 6(a) of the Securities Act of 1933, the undersigned has signed this registration statement, in the capacity of the duly authorized representative of Medicure Inc. in the United States, in Mill Neck, New York on this 9th day of October, 2007.

   By: /s/ Peter Quick
    Name: Peter Quick
    Title: Director

II-9


EXHIBIT INDEX

Exhibit Number                                                                                                   Exhibit
4.1 Medicure Inc. Stock Option Plan Amended and Restated October 2, 2007
4.2 Form of Stock Option Agreement for Stock Option Plan
5.1 Opinion of Lang Michener LLP
23.1 Consent of KPMG LLP
23.5 Consent of Lang Michener LLP (contained in its opinion filed as Exhibit 5.1)
24.1 Power of Attorney (See page II-8 of this registration statement)

II-10



MEDICURE INC.

STOCK OPTION PLAN
Amended and Restated as of October 2, 2007

1.

Purpose. The purpose of the Stock Option Plan (the “ Plan ”) of Medicure Inc. (the “ Corporation ”), a Corporation incorporated under the federal laws of Canada, is to advance the interests of the Corporation by encouraging its directors, management, consultants and employees to acquire shares in the Corporation, thereby increasing their proprietary interest in the Corporation, encouraging them to remain associated with the Corporation and furnishing them with additional incentive in their efforts on behalf of the Corporation in the conduct of its affairs.

   
2.

Administration. The Plan shall be administered by the board of directors of the Corporation (the “ Board ”).

   

Subject to the provisions of the Plan, the Board shall have authority to construe and interpret the Plan and all Option Agreements entered into thereunder, to define the terms used in the Plan and in all Option Agreements entered into thereunder, to prescribe, amend and rescind rules and regulations relating to the Plan, subject to any necessary regulatory approvals of the Toronto Stock Exchange (“ TSX ”), and to make all other determinations necessary or advisable for the administration of the Plan. All determinations and interpretations made by the Board shall be binding and conclusive on all participants in the Plan and on their legal personal representatives and beneficiaries.

   

Each option granted hereunder ( an “Option ”) shall be evidenced by an agreement (an “ Option Agreement ”), signed on behalf of the Corporation and by the optionee, in such form as the directors shall approve. Each such agreement shall recite that it is subject to the provisions of this Plan.

   
3.

Shares Subject to Plan. Subject to adjustment as provided in Section 14 hereof, the shares to be offered under the Plan shall consist of common shares of the Corporation (“ Shares ”) which shall be issued from treasury for purposes of the Plan. The aggregate number of Shares that may be reserved for issuance at any time pursuant to Options granted under this Plan shall not exceed 10% of the total number of Shares issued and outstanding at the date of any grant made hereunder. Any exercise of an Option granted under the Plan will result in an additional grant being available under the Plan. If any Option shall expire or terminate for any reason without having been exercised in full, the unpurchased Shares subject thereto shall again be available for the purpose of this Plan.

   
4.

Maintenance of Sufficient Capital. The Corporation shall at all times during the term of this Plan reserve and keep available such numbers of Shares as will be sufficient to satisfy the requirements of the Plan.




5.

Eligibility and Participation. Directors, officers, management, consultants and employees of the Corporation shall be eligible for selection to participate in the Plan (such persons hereinafter collectively referred to as “ Participants ”). The Board shall determine to whom Options shall be granted, the terms and provisions of the respective Option Agreements, the time or times at which such Options shall be granted, and the number of Shares to be subject to each Option. An individual who has been granted an Option may, if he is otherwise eligible, and if permitted under the policies of the stock exchange or stock exchanges on which the Shares are to be listed, be granted an additional Option or Options if the directors shall so determine.

     
6.

Exercise Price

     
(a)

The exercise price of the Shares covered by each Option shall be determined by the Board. Subject to the provisions of Section 6(b), the exercise price shall be not less than the closing price of the Shares on the primary stock exchange on which the Shares are listed on the last trading day immediately preceding the day on which the Option is granted.

     
(b)

If an Option is granted within six months of a public distribution of the Shares by way of prospectus, then the minimum exercise price of such Option shall, if the policy of such stock exchange or stock exchanges requires, be the greater of the price determined pursuant to Section 6(a) and the price per Share paid by the investing public for Shares acquired by the public during such public distribution, determined in accordance with the policy of such stock exchange or stock exchanges.

     
7.

Number of Optioned Shares.

     
(a)

The number of Shares issuable to Insiders, at any time, under all security based compensation arrangements, cannot exceed 10% of the issued and outstanding Shares.

     
(b)

The number of Shares issued to Insiders, within any one year period, under all security based compensation arrangements, cannot exceed 10% of the issued and outstanding Shares.

     
(c)

Insider ” means any insider of the Corporation (as such term is defined in subsection 1(1) of the Securities Act (Ontario) as amended from time to time), other than a person who falls within that definition solely by virtue of being a director or officer of a subsidiary of the Corporation, and includes any “associate” of any insider (as such term is defined in the said subsection as amended from time to time).




8.

Duration of Option.

     
(a)

Each Option and all rights thereunder shall be expressed to expire on the date set out in the Option Agreements and shall be subject to earlier termination as provided in paragraphs 10 and 11.

     
(b)

Notwithstanding any other provision of this Plan, no Option shall terminate, become void and of no effect or cease to be exercisable, whether as a result of the expiry of the term fixed for exercise of the Option or as a result of the termination or cessation of employment of an optionee, prior to 5:00 p.m. (Toronto time) on the tenth business day following the cessation of any Trading Blackout applicable to such optionee in effect at the time such Option would otherwise expire or terminate or if a Trading Blackout is not then in effect, prior to 5:00 p.m. (Toronto time) on the tenth business day following cessation of the most recent Trading Blackout applicable to such optionee prior to the Expiry Date.

     
(c)

Trading Blackout ” means any restricted trading period imposed by the Corporation during which the directors and officers of the Corporation and specified employees are prohibited from trading in the securities of the Corporation.

     
9.

Option Period, Consideration and Payment.

     
(a)

The Option Period shall be a period of time fixed by the Board, not to exceed ten years from the date the Option is granted, provided that the Option Period shall be reduced with respect to any Option as provided in Sections 10 and 11 covering cessation as a director, officer, consultant or employee of the Corporation or death of the Participant.

     
(b)

An Option shall vest and may be exercised (in each case to the nearest full Share) during the Option Period in such manner as the Board may fix by resolution. Options which have vested may be exercised in whole or in part at any time and from time to time during the Option Period.

     
(c)

Except as set forth in Section 10 and 11, no Option may be exercised unless the Participant is at the time of such exercise a director, officer, manager, consultant, or employee of the Corporation. In the case of a consultant, where the Option has been granted for a specific service, the Option may be exercised only upon completion of that service.

     
(d)

The exercise of any Option will be contingent upon receipt by the Corporation at its head office of a written notice of exercise, specifying the number of Shares with respect to which the Option is being exercised, accompanied by cash payment, certified cheque or bank draft for the full purchase price of such Shares with respect to which the Option is exercised. No Participant or his legal




representatives, legatees or distributes will be, or will deemed to be, a holder of any Shares subject to an Option under this Plan, unless and until the certificate for such Shares are issued to him or them under the terms of the Plan.
     
10.

Ceasing to Be a Director, Consultant, Officer, Manager, Consultant or Employee.

     

If a Participant shall cease to be a director, officer, manager, consultant or employee of the Corporation or a company for any reason (other than death), he may, but only within the earlier of the original expiry date and 90 days next succeeding his ceasing to be a director, officer, manager, consultant, or employee, exercise his Option to the extent that he was entitled to exercise it at the date of such cessation.

     

Nothing contained in the Plan, nor in any Option granted pursuant to the Plan, shall as such confer upon any Participant any right with respect to continuance as a director, officer, manager, consultant or employee of the Corporation or of any affiliate.

     
11.

Death of Participant. In the event of the death of a Participant, the Option previously granted to him shall be exercisable only by the earlier of the original expiry date and the date that is twelve months after the date of death and then only:

     
(a)

by the person or persons to whom the Participant’s rights under the Option shall pass by the Participant’s will or the laws of descent and distribution; and

     
(b)

if and to the extent that he was entitled to exercise the Option at the date of his death.

     
12.

Right of Optionee. No person entitled to exercise any Option granted under the Plan shall have any of the rights or privileges of a shareholder of the Corporation in respect of any Shares issuable upon exercise of such Option until certificates representing such Shares shall have been issued and delivered.

     
13.

Proceeds from Sales of Shares. The proceeds from sales of Shares issued upon the exercise of Options shall be added to the general funds of the Corporation and shall thereafter be used from time to time for such corporate purposes as the Board may determine and direct.

     
14.

Adjustments. If the outstanding Shares of the Corporation are increased, decreased, changed into or exchanged for a different number or kind of shares of securities of the Corporation through re-organization, merger, re-capitalization, re-classification, stock dividend, subdivision or consolidation, an appropriate and proportionate adjustment shall be made in the maximum number of kind of shares as to which Options may be granted under the Plan. A corresponding adjustment changing the number or kind of shares allocated to unexercised Options or portions thereof, which shall have been granted prior to any such change, shall likewise be made. Any such adjustment in the outstanding Options shall be made without change in the aggregate purchase price applicable to the



unexercised portion of the Option but with a corresponding adjustment in the price for each share or other unit of any security covered by the Option.

Upon the liquidation or dissolution of the Corporation or upon a re-organization, merger or consolidation of the Corporation with one or more corporations as a result of which the Corporation is not the surviving corporation, or upon the sale of substantially all of the property or more than eighty (80%) percent of the then outstanding Shares of the Corporation to another corporation, the Plan shall terminate, and any Options theretofore granted hereunder shall terminate unless provision is made in writing in connection with such transaction for the continuance of the Plan and for the assumption of Options theretofore granted, or the substitution for such Options of new options covering the shares of a successor employer corporation, or a parent or subsidiary thereof, with appropriate adjustments as to number and kind of shares and prices, in which event the Plan and Options theretofore granted shall continue in the manner and upon the terms so provided. If the Plan and outstanding Options shall terminate pursuant to the foregoing sentence, then immediately prior to consummation of the event which results in the termination of the Plan and outstanding Options, the Board may determine that all of the Options of an optionee vest and become exercisable for such period as the Board specifies. Options not exercised within the specified period will terminate.

Adjustments under this Section shall be made by the Board, subject to the approval of the primary stock exchange on which the shares of the Corporation are listed, whose determination as to what adjustments shall be made, and the extent thereof, shall be final, binding and conclusive. No fractional share shall be issued under the Plan on any such adjustment.

14.1 Change of Control. If a bona fide offer (the “ Offer ”) for voting or equity shares is made to shareholders of the Corporation generally, or to a class of shareholders of the Corporation which, if Options were exercised, would include the Participants, and which Offer, if accepted in whole or in part, would result in the offeror exercising control over the Corporation within the meaning of subsection 1(3) of the Securities Act (Ontario) then, notwithstanding Sections 8 and 9 but subject to the other provisions hereof:

  (a)

The Board may give its express consent to the exercise of any Options which are outstanding although not yet exercisable at the time of the Offer in the manner hereinafter provided.

     
  (b)

If the Board has so consented to the exercise of any Options outstanding at the time of the Offer, the Corporation shall, immediately after such consent has been given, notify each Participant currently holding an Option of the Offer, with full particulars thereof, together with a notice stating that, in order to permit the Participant to participate in the Offer, the Participant may, during the period that the Offer is open for acceptance (or, if no such period is specified, the period of 30 days following the date




 

of such notice), exercise all or any portion of any such Option held by the Participant.

       
  (c)

In the event that the Participant so exercises any such Option, such exercise shall be in accordance with Sections 6, 7 and 9(d) hereof; provided that, if necessary in order to permit the Participant to participate in the Offer, such Option shall be deemed to have been exercised, and the issuance of Shares received upon such exercise (the “ Optioned Shares ”) shall be deemed to have occurred, effective as of the first day prior to the date on which the Offer was made.

       
  (d)

If, upon the expiry of the applicable period referred to in subsection (b) above, the Offer is completed, and:

       
  (i)

the Participant has not exercised the entire or any portion of such Option then, as of and from the expiry of such period, the Participant’s right to purchase the Shares covered by such Option shall not be exercisable, and shall expire and be null and void; and

       
  (ii)

the Participant has exercised the entire or any portion of such Option, but has not tendered the Shares received in connection with such exercise to the Offer, then, as and from the expiry of such period, the Corporation may require the Participant to sell to the Corporation such Optioned Shares for a purchase price of $.001 per Optioned Share.

       
  (e)

If:

       
  (i)

the Offer is not completed (within the time specified therein, if applicable);

       
 

or

       
  (ii)

all of the Optioned Shares tendered by the Participant pursuant to the Offer are not taken up and paid for by the offeror in respect thereof;

       
 

then the Optioned Shares or, in the case of paragraph (ii) above, the portion thereof that is not taken up and paid for by such offeror, shall be returned by the Holder to the Corporation for cancellation and the terms of the Option as set forth herein shall again apply to such Option, or the remaining portion thereof, as the case may be.

       
  (f)

If any Optioned Shares are returned to the Corporation pursuant to subsection (e) above, the Corporation shall refund the Option price to the Participant in respect of such Optioned Shares.




 

(g)

 In no event shall the Participant be entitled to sell the Optioned Shares otherwise than pursuant to the Offer, except as provided in paragraph (d)(ii) above.

     
15.

Transferability. All benefits, rights and Options accruing to any Participant in accordance with the terms and conditions of the Plan shall not be transferable or assignable unless specifically provided herein. During the lifetime of a Participant any benefits, rights and Options may only be exercised by the Participant.

     
16.

Amendment and Termination of Plan.

     
(a)

The Board may, at any time, suspend or terminate the Plan or amend or revise the terms of the Plan, provided that no such amendment or revisions shall alter the terms of any Options theretofore granted under the Plan. Subject to Section 16(b) and subject to any necessary approval of the TSX or any other Stock Exchange on which the Shares may be listed, the Board may, from time to time, and without the approval of the Company’s shareholders: (i) amend the Plan and the terms and the conditions of any Options thereafter to be granted; and (ii) with the consent of the affected holder of an Option, amend the Plan and the terms and conditions of any Options which have been theretofore granted.

     
(b)

The shareholders of the Company shall approve any amendment to the Plan or any Option which (i) reduces the exercise price of an Option granted to an Insider ; (ii) extends the period available to exercise an Option granted to an Insider other than as provided in Section 8(b); or (iii) increases the number of shares reserved for issuance under the Plan (other than pursuant to the provisions of Section 14 hereof).

     
17.

Necessary Approvals. The obligation of the Corporation to issue and deliver Shares in accordance with the Plan is subject to any approvals which may be required from any regulatory authority or stock exchange having jurisdiction over the securities of the Corporation. If any Shares cannot be issued to any Participant for whatever reason, the obligation of the Corporation to issue such Shares shall terminate and any Option exercise price paid to the Corporation will be returned to the Participant.

     
18.

Stock Exchange Rules. The rules of any stock exchange upon which the Corporation’s Shares are listed shall be applicable relative to Options granted to Participants.

     
19.

Effective Date of Plan. The Plan has been adopted by the Board of the Corporation subject to the approval of the stock exchange or stock exchanges on which the Shares of the Corporation are to be listed and, if so approved, the Plan shall became effective upon such approvals being obtained.




20.

Interpretation. The Plan will be governed by and construed in accordance with the laws of Canada.


  MEDICURE INC.
   
  Per: /s/ Albert D. Friesen
     
  Per: /s/ Derek Reimer



STOCK OPTION AGREEMENT

THIS AGREEMENT made as of the XX day of XX 2007.

BETWEEN:

OPTIONEE NAME , an individual of the City of
XX, in the Province of XX
(herein referred to as the “Optionee”)

-and-

MEDICURE INC. , a body corporate, incorporated federally under the
laws of Canada, having an office in the City of Winnipeg, in the Province
of Manitoba
(herein referred to as the “Corporation”)

WHEREAS:

1. the Corporation is incorporated under the laws of Canada, having an authorized capital consisting of an unlimited number of common shares without nominal or par value and an unlimited number of preferred shares without nominal or par value; and 2. the Board has agreed to grant unto the Optionee an option to purchase an aggregate of XX,000 common shares without par value of its authorized unissued share capital in consideration of the Optionee’s ongoing services and contributions to the Corporation or any of its subsidiaries or affiliates; and 3. the granting of such option to the Optionee was authorized by the Board effective XX, 2007.

ARTICLE 1
DEFINITIONS

1.01 In this Agreement the following terms shall have the following meanings:

(a)

“Agreement”, “herein”, “hereto”, “hereof” and similar expressions means this Agreement, and includes any Agreement amending this Agreement or any Agreement or instrument which is supplemental or ancillary hereof;

   
(b)

“Board” means the Board of Directors of the Corporation;

   
(c)

“Expiration Date” means XX, 2017;

   
(d)

“Option Date” in respect of the Share Option means the date of this Agreement;

   
(e)

“Option Shares” means the Shares the Optionee is entitled to purchase under a Share Option;

   
(f)

“Share” means a common share of the Corporation as constituted at the date hereof;




(g)

“Share Option” means an option to purchase Treasury Shares granted to the Optionee pursuant to this Agreement, and includes any portion of that option; and

   
(h)

“Treasury Share” means a theretofore unissued Share which is purchased directly from the Corporation by or for the account of the Optionee.

1.02 In the Agreement, the masculine gender shall include the feminine gender and the singular shall include the plural and vice versa wherever the context requires.

ARTICLE II
SHARE OPTION

2.01 The Corporation hereby grants to the Optionee, subject to the terms and conditions hereinafter set out, an irrevocable option to purchase at any time or from time to time on or before the Expiration Date, XX,000 Shares of the Corporation at a price of $XX per Share.

2.02 The Share Option shall vest and shall be exercisable over a period of three years, at 33 1/3% per year, with the first 33 1/3% of the Share Option vesting on the first anniversary of XX, 2007, the second 33 1/3% of the Share Option vesting on the second anniversary of XX, 2007, and the third 33 1/3% of the Share Option vesting on the third anniversary of XX, 2007.

2.03 At 4:30 p.m., Winnipeg time, on the Expiration Date, the Share Option or any portion thereof remaining unexercised shall forthwith expire and terminate and be of no further force or effect whatsoever as to such of the Option Shares in respect of which the Share Option hereby granted has not then been exercised.

ARTICLE III
CURRENCY DURING TERM OF EMPLOYMENT

3.01 (a)

If an Optionee shall cease to be a director, officer, consultant, scientific advisory board member or employee of the Corporation or any of its subsidiaries or affiliates, as the case may be, for any reason (other than death), he may but only within sixty (60) days next succeeding his ceasing to be a director, officer, consultant, scientific advisory board member or employee, exercise his Share Option to the extent that he was entitled to exercise it at the date of such cessation.

     
(b)

In the event of the death of an Optionee, the Share Option previously granted to him shall be exercisable only within the twelve (12) months next succeeding such death and then only by the person or persons to whom the Optionee’s rights under the Share Option shall pass by the Optionee’s will or the laws of descent and distribution and if and to the extent that he was entitled to exercise the Share Option at the date of his death.



ARTICLE IV
MATERIAL CHANGE

4.01 In the event that, prior to the Expiration Date or exercise in full of the Share Option, the outstanding share capital of the Corporation shall be subdivided or consolidated into a greater or lesser number of Shares, or, in the event of the payment of a stock dividend by the Corporation, or in the event that all of the shareholders of the Corporation are granted the right to purchase additional Shares of the Corporation, the number and price of Option Shares remaining subject to the Share Option hereunder shall be increased or reduced accordingly, as the case may be.

4.02 If, prior to the Expiration Date or exercise in full of the Share Option granted hereby, the Corporation shall, enter into an arrangement with or merge into another corporation, the Optionee will thereafter receive, upon the exercise of the Share Option, the securities or properties to which a holder of the number of Shares then deliverable upon the exercise of the Share Option would have been entitled upon such arrangement or merger, and the Corporation will take steps in connection with such arrangement or merger as may be necessary to assure that the provisions hereof shall thereafter be applicable, in relation to any securities or property thereafter deliverable upon the exercise of the Option granted hereby. A sale of all or substantially all of the assets of the Corporation for consideration, (apart from the assumption of obligations), consisting primarily of securities shall be deemed to be an arrangement or merger for the foregoing purposes.

ARTICLE V
RESERVATION OF TREASURY SHARES

5.01 The Corporation shall at all times during the term of this Agreement, reserve and keep available a sufficient number of Treasury Shares to satisfy the requirement hereof.

ARTICLE VI
RESTRICTION ON ASSIGNMENT

6.01 The Share Option granted hereby is, insofar as the Optionee is concerned, personal and non-assignable and neither this Agreement nor any rights in regard thereto shall be transferable or assignable except upon the death of the Optionee pursuant to Clause 3.01 hereof.

ARTICLE VII
EXERCISE OF THE SHARE OPTION

7.01 The Share Option may be exercised by the Optionee in accordance with the provisions hereof in whole or in part, from time to time, by delivery of written notice of such exercise and by tendering the payment therefor in cash or by certified cheque to the Corporation at its principal office in the City of Winnipeg, in the Province of Manitoba. Such notice shall state the number of the Option shares with respect to which the Share Option is then being exercised. The Share Option shall be deemed for all


purposes to have been exercised to the extent stated in such notice upon delivery of the notice and tender of payment in full, not withstanding any delay in the issuance and delivery of the certificates for the Shares so purchased.

ARTICLE VIII
RIGHTS OF THE OPTIONEE PRIOR TO EXERCISE DATE

8.01 The Share Option herein granted shall not entitle the Optionee to any rights whatsoever as a shareholder of the Corporation with respect to any Shares subject to the Share Option until it has been exercised in accordance with Clause 7.01 and Option Shares have been issued as fully paid and non-assessable.

ARTICLE IX
FURTHER ASSURANCE

9.01 The parties hereto covenant that they shall and will from time to time and at all times hereafter do and perform all such acts and things and execute all such additional documents as may be required to give effect to the terms and intention of this Agreement.

ARTICLE X
INTERPRETATION

10.01 It is understood and agreed by the parties hereto that questions may arise as to the interpretation, construction or enforcement of this Agreement and the parties are desirous of having the Board determine any such question of interpretation, construction or enforcement. It is therefore understood and agreed by and between the parties hereto that any question arising under the terms of this Agreement as to interpretation, construction or enforcement shall be referred to the Board and its majority decision shall be final and binding on both of the parties hereto.

ARTICLE XI
ENTIRE AGREEMENT

11.01 This Agreement supersedes all other agreements, documents, writings and verbal understandings among the parties relating to the subject matter hereof and represents the entire agreement between the parties relating to the subject matter hereof.

ARTICLE XII
ENUREMENT

12.01 Subject to the other provisions hereof, this Agreement shall enure to the benefit of and be binding upon the parties hereto and their respective heirs, executors, administrators, successors and permitted assigns.

12.02 This Agreement shall constitute a binding obligation of the Corporation notwithstanding any change of control of its voting securities during the term hereof.


     IN WITNESS WHEREOF the parties hereto have executed this Agreement as of the day and year first above written.

SIGNED )  
in the presence of: )  
  )  
  )  
     
  )  
                      OPTIONEE NAME

  MEDICURE INC.
     
   Per:
     
   Per:



Lang Michener LLP
BARRISTERS & SOLICITORS

Vancouver
Toronto
Ottawa
1500 - 1055 West Georgia Street, P.O. Box 11117
Vancouver, British Columbia, Canada V6E 4N7
Telephone (604) 689-9111
Facsimile (604) 685-7084

 


October 5, 2007 Geofrey Myers
  Direct Line: 416-307-4040
  E-mail: gmyers@langmichener.ca

United States
Securities and Exchange Commission
Washington, D.C. 20549

Dear Sirs/Mesdames:

Re: Medicure Inc.

We have acted as corporate counsel to Medicure Inc., a company existing under the laws of Canada (the “Company”), in connection with the registration by the Company pursuant to a registration statement (the “Registration Statement”) on Form S-8 filed with the Securities and Exchange Commission (the “Commission”) under the Securities Act of 1933, as amended (the “Securities Act”), relating to the registration of 13,030,755 common shares of the Company, no par value (the “Common Shares”), issuable pursuant to awards granted under the Company’s Stock Option Plan (the “Plan”).

This opinion is being delivered in connection with the Registration Statement, to which this opinion is attached as an exhibit.

We have examined the Registration Statement, and, for the purposes of this opinion, we have also examined the originals, or duplicate, certified, conformed, telecopied or photostatic copies, of such corporate records, agreements, documents and other instruments and have made such other investigations as we have considered necessary or relevant for the purposes of this opinion. With respect to the accuracy of factual matters material to this opinion, we have relied upon the financial statements of the Company, certificates or comparable documents and representations of public officials and of officers and representatives of the Company.

In giving this opinion, we have assumed the genuineness of all signatures, the legal capacity of natural persons, the authenticity of all documents submitted to us as originals, the conformity to authentic original documents of all documents submitted to us as duplicates, certified, conformed, telecopied or photostatic copies and the authenticity of the originals of such latter documents.

We are qualified to express opinions only with respect to the laws of the province of Ontario and the federal laws of Canada applicable therein. We express no opinion on the laws of any

www.langmichener.ca Toronto Vancouver Ottawa



Lang Michener LLP  
Lawyers – Patent & Trade Mark Agents Page 2

jurisdiction other than the laws of the province of Ontario and the federal laws of Canada applicable therein.

Based and relying upon the foregoing, and subject to the qualifications, assumptions and limitations stated herein, we are of the opinion that the Common Shares have been duly authorized and, upon issuance, delivery and payment therefor in accordance with the terms of the Plan and any relevant agreements thereunder, will be validly issued, fully paid and non-assessable.

We hereby consent to the filing of this opinion as Exhibit 5.1 to the Registration Statement.

If you have any questions concerning the foregoing, please contact the undersigned.

Yours truly,

/s/ Lang Michener LLP

www.langmichener.ca Toronto Vancouver Ottawa




CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM

The Board of Directors
Medicure Inc.

We consent to the use of our report dated August 22, 2007, with respect to the consolidated balance sheets of Medicure Inc. as of May 31, 2007 and 2006, and the related consolidated statements of operations and deficit and cash flows for each of the years in the three-year period ended May 31, 2007, incorporated by reference in the Registration Statement on Form S-8 (Stock Option Plan Amended and Restated October 2, 2007).

Signed "KPMG LLP"

Chartered Accountants

Winnipeg, Canada
October 9, 2007

KPMG LLP, is a Canadian limited liability partnership and a member firm of the KPMG network of
independent member firms affiliated with KPMG International, a Swiss cooperative.
KPMG Canada provides services to KPMG LLP