U.S. SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

 


 

FORM 10-Q

x                               QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934

For the quarterly period ended September 30, 2006

or

o                                  TRANSITION REPORT UNDER SECTION 13 OR 15 (d) OF THE SECURITIES EXCHANGE ACT OF 1934

For the transition period from            to            

 


 

Commission File Number: 000-31979

Array BioPharma Inc.

(Exact Name of Registrant as Specified in Its Charter)

 


Delaware

 

84-1460811

(State or Other Jurisdiction of

 

(I.R.S. Employer Identification No.)

Incorporation or Organization)

 

 

 

 

 

3200 Walnut Street, Boulder, CO

 

80301

(Address of Principal Executive Offices)

 

(Zip Code)

 

(303) 381-6600

(Registrant’s Telephone Number, Including Area Code)

 


Indicate by check mark whether the registrant: (1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during the preceding 12 months (or for such shorter period that the registrant was required to file such reports), and (2) has been subject to such filing requirements for the past 90 days.

Yes x   No o

Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, or a non-accelerated filer. See definition of “accelerated filer and large accelerated filer” in Rule 12b-2 of the Exchange Act.

(Check one): Large Accelerated Filer  o        Accelerated Filer   x           Non-Accelerated Filer  o

Indicate by check mark whether the registrant is a shell company (as defined in Rule 12b-2 of the Exchange Act).

Yes o No x

As of October 31, 2006, the registrant had 39,235,628 shares of common stock, par value $.001 per share, outstanding.

 




 

ARRAY BIOPHARMA INC.

TABLE OF CONTENTS

 

 

 

PAGE

PART I - FINANCIAL INFORMATION

 

 

 

 

 

 

 

Item 1.

 

Condensed Financial Statements

 

 

 

 

 

 

 

 

 

Balance Sheets at September 30, 2006 and June 30, 2006 (unaudited)

 

3

 

 

 

 

 

 

 

Statements of Operations — Three Months Ended September 30, 2006 and 2005 (unaudited)

 

4

 

 

 

 

 

 

 

Statements of Cash Flows — Three Months Ended September 30, 2006 and 2005 (unaudited)

 

5

 

 

 

 

 

 

 

Notes to Condensed Financial Statements (unaudited)

 

6

 

 

 

 

 

Item 2.

 

Management’s Discussion and Analysis of Financial Condition and Results of Operations

 

13

 

 

 

 

 

Item 3.

 

Quantitative and Qualitative Disclosures About Market Risk

 

20

 

 

 

 

 

Item 4.

 

Controls and Procedures

 

21

 

 

 

 

 

PART II - OTHER INFORMATION

 

 

 

 

 

 

 

Item 6.

 

Exhibits

 

21

 

 

 

 

 

SIGNATURES

 

22

 

2




 

PART I

Item 1. Financial Statements

ARRAY BIOPHARMA INC.
CONDENSED BALANCE SHEETS
(Unaudited)
(In thousands)

 

 

September 30,

 

June 30,

 

 

 

2006

 

2006

 

ASSETS

 

 

 

 

 

Current assets

 

 

 

 

 

Cash and cash equivalents

 

$

13,744

 

$

15,568

 

Marketable securities

 

82,096

 

54,532

 

Accounts receivable, net

 

184

 

1,359

 

Inventories, net

 

1,606

 

1,645

 

Prepaid expenses and other

 

2,006

 

1,760

 

Total current assets

 

99,636

 

74,864

 

 

 

 

 

 

 

Property, plant and equipment

 

66,999

 

66,139

 

Less accumulated depreciation and amortization

 

(40,428

)

(38,830

)

Property, plant and equipment, net

 

26,571

 

27,309

 

Total assets

 

$

126,207

 

$

102,173

 

 

 

 

 

 

 

 

 

 

 

 

 

LIABILITIES AND STOCKHOLDERS’ EQUITY

 

 

 

 

 

 

 

 

 

 

 

Current liabilities

 

 

 

 

 

Accounts payable

 

$

5,461

 

$

6,212

 

Advance payments from collaborators — current

 

3,153

 

3,800

 

Accrued compensation and benefits

 

6,714

 

5,770

 

Deferred rent — current

 

2,628

 

1,563

 

Other current liabilities

 

1,516

 

1,511

 

Total current liabilities

 

19,472

 

18,856

 

 

 

 

 

 

 

Advance payments from collaborators — long term

 

66

 

78

 

Deferred rent — long term

 

29,194

 

 

Long term debt

 

15,000

 

14,150

 

Other long term liabilities

 

492

 

448

 

Total liabilities

 

64,224

 

33,532

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Stockholders’ equity

 

 

 

 

 

Preferred stock

 

 

 

Common stock

 

39

 

39

 

Additional paid-in capital

 

203,925

 

202,526

 

Accumulated other comprehensive income (loss)

 

(96

)

(270

)

Accumulated deficit

 

(141,885

)

(133,654

)

Total stockholders’ equity

 

61,983

 

68,641

 

Total liabilities and stockholders’ equity

 

$

126,207

 

$

102,173

 

 

See notes to condensed financial statements

3




 

ARRAY BIOPHARMA INC.
CONDENSED STATEMENTS OF OPERATIONS
(Unaudited)
(In thousands, except per share data)

 

 

Three Months Ended

 

 

 

September 30,

 

 

 

2006

 

2005

 

Revenue

 

 

 

 

 

Collaboration revenue

 

$

7,989

 

$

8,284

 

License and milestone revenue

 

3,037

 

2,958

 

Total revenue

 

11,026

 

11,242

 

 

 

 

 

 

 

Operating expenses

 

 

 

 

 

Cost of revenue

 

6,267

 

9,390

 

Research and development for proprietary drug discovery

 

10,853

 

8,625

 

Selling, general and administrative expenses

 

2,969

 

3,454

 

Total operating expenses

 

20,089

 

21,469

 

 

 

 

 

 

 

Loss from operations

 

(9,063

)

(10,227

)

 

 

 

 

 

 

Interest expense

 

(240

)

(129

)

Interest income

 

1,072

 

684

 

Net loss

 

$

(8,231

)

$

(9,672

)

 

 

 

 

 

 

Basic and diluted net loss per share

 

$

(0.21

)

$

(0.25

)

 

 

 

 

 

 

Number of shares used to compute per share data

 

39,148

 

38,498

 

 

See notes to condensed financial statements

4




 

ARRAY BIOPHARMA INC.
CONDENSED STATEMENTS OF CASH FLOWS
(Unaudited)
(In thousands)

 

 

Three Months Ended

 

 

 

September 30,

 

 

 

2006

 

2005

 

Operating activities

 

 

 

 

 

Net loss

 

$

(8,231

)

$

(9,672

)

Adjustments to reconcile net loss to net cash used in operating activities:

 

 

 

 

 

Depreciation and amortization

 

1,596

 

2,352

 

Share-based compensation expense

 

1,202

 

1,746

 

Deferred rent credits

 

(2,016

)

(77

)

Changes in operating assets and liabilities

 

553

 

(3,374

)

 

 

 

 

 

 

Net cash used in operating activities

 

(6,896

)

(9,025

)

 

 

 

 

 

 

Investing activities

 

 

 

 

 

Purchases of property, plant and equipment

 

(860

)

(1,548

)

Purchases of marketable securities

 

(39,415

)

(23,884

)

Proceeds from sale and maturity of marketable securities

 

12,025

 

28,525

 

Net proceeds from assignment of facility purchase options

 

32,275

 

 

Increase in restricted cash

 

 

(20

)

 

 

 

 

 

 

Net cash provided by investing activities

 

4,025

 

3,073

 

 

 

 

 

 

 

Financing activities

 

 

 

 

 

Proceeds from exercise of stock options and shares issued under the employee stock purchase plan

 

197

 

354

 

Proceeds from the issuance of long term debt

 

850

 

1,327

 

 

 

 

 

 

 

Net cash provided by financing activities

 

1,047

 

1,681

 

 

 

 

 

 

 

 

 

 

 

 

 

Net decrease in cash and cash equivalents

 

(1,824

)

(4,271

)

Cash and cash equivalents, beginning of period

 

15,568

 

12,430

 

 

 

 

 

 

 

Cash and cash equivalents, end of period

 

$

13,744

 

$

8,159

 

 

Supplemental disclosure of cash flow information

Cash paid for interest was $229 and $84 for the three months ended September 30, 2006 and 2005, respectively.

See notes to condensed financial statements

5




 

ARRAY BIOPHARMA INC.

NOTES TO CONDENSED FINANCIAL STATEMENTS

September 30, 2006

(Unaudited)

(In thousands, except share and per share data, unless otherwise noted)

Note 1: Basis of Presentation and Summary of Significant Accounting Policies

Interim Financial Statements

The accompanying unaudited condensed financial statements have been prepared in accordance with accounting principles generally accepted in the United States and with the instructions to Form 10-Q and Article 10 of Regulation S-X for interim financial information. Accordingly, they do not include all of the information and footnotes required by accounting principles generally accepted in the United States for complete financial statements. In the opinion of management, all adjustments (consisting of normal recurring adjustments) considered necessary for a fair presentation have been included. Operating results for the three months ended September 30, 2006 are not necessarily indicative of the results that may be expected for the year ending June 30, 2007. For further information, refer to the financial statements and footnotes thereto as of and for the year ended June 30, 2006, included in the Annual Report on Form 10-K of Array BioPharma Inc. (the “ Company ” or “ Array ”) filed on September 1, 2006, with the Securities and Exchange Commission.

Summary of Significant Accounting Policies

   Cash Equivalents and Marketable Securities

Cash equivalents consist of short term, highly liquid financial instruments that are readily convertible to cash and have maturities of three months or less from the date of purchase and may consist of money market funds, taxable commercial paper, U.S. government agency obligations and corporate notes and bonds with high credit quality. Marketable securities consist of similar financial instruments with maturities of greater than three months.

At September 30, 2006 and June 30, 2006, management designated marketable securities held by the Company as available-for-sale securities for purposes of Statement of Financial Accounting Standards No. 115, Accounting for Certain Investments in Debt and Equity Securities. Securities available-for-sale are carried at fair value, with unrealized gains and losses reported as a component of stockholders’ equity until their disposition. The amortized cost of debt securities in this category is adjusted for amortization of premiums and accretion of discounts to maturity. Such amortization is included in investment income. Realized gains and losses, declines in value judged to be other-than-temporary on securities available-for-sale and interest on securities available-for-sale are included in investment income. The cost of securities sold is based on the specific identification method.

   Inventories

Inventories consist of individual chemical compounds in the form of Optimer â  building blocks available-for-sale and commercially available fine chemicals used in the Company’s proprietary drug discovery programs and research collaborations. Inventories are stated at the lower of cost or market, cost being determined under the first-in, first-out method. The Company reviews its chemical inventories periodically and writes down the carrying cost for non-marketability to estimated net realizable value through an appropriate reserve.

   Deferred Rent

During July and August 2006, the Company terminated its existing facility leases and executed new lease agreements with a different landlord. Accordingly, the entire June 30, 2006 deferred rent balance of $1.6 million was reversed and recorded as a reduction to the Company’s recognized rent expense for the first quarter of fiscal 2007. The Company’s current facilities leases provide for annual rent increases, and the Company recognizes the average annual rent expense over the term of these leases on a straight-line basis. As a result, the amount of average annual rent expense will exceed the Company’s actual cash rent payments during the early part of the lease term and

6




be below the actual cash rent payments during the latter part of the lease term. Additionally, in conjunction with the assignment of facility purchase options as described in Note 5: “Operating Leases”, the Company received net proceeds of $32.3 million which was recorded as deferred rent and will be recognized on a straight-line basis as a reduction to rent expense over the related ten-year term of the new facilities leases. The current portion of the deferred rent balance reflected on the Company’s balance sheet represents the amount of expected deferred rent credits to be applied as a reduction to the Company’s rent expense over the next twelve-month period.

   Revenue Recognition

Most of the Company’s revenue is derived from designing, creating, optimizing, evaluating and developing drug candidates for its collaborators. The majority of collaboration revenue consists of fees received based on contracted annual rates for full time equivalent employees working on drug discovery programs. The Company’s collaboration agreements also include license and up-front fees, milestone payments upon achievement of specified research or development goals and royalties on sales of resulting products. A small portion of the Company’s revenue comes from fixed fee agreements and from sales of compounds on a per-compound basis.

Collaboration agreements typically call for a specific level of resources as measured by the number of full time equivalent scientists working a defined number of hours per year at a stated price under the agreement. The Company recognizes revenue under its collaboration agreements on a monthly basis as work is performed. The Company recognizes revenue from sales of Lead Generation Library and Optimer building block compounds as the compounds are shipped, as these agreements are priced on a per-compound basis and title and risk of loss passes upon shipment to the Company’s customers.   In general, contract provisions include predetermined payment schedules or the submission of appropriate billing detail. Payments received in advance of performance are recorded as advance payments from collaborators until the revenue is earned.

Revenue from license fees and up-front fees is non-refundable and is recognized on a straight-line basis over the expected period of the related research program. Milestone payments are non-refundable and are recognized as revenue over the expected period of the related research program. A portion of each milestone payment is recognized when the milestone is achieved based on the applicable percentage of the research term that has elapsed. Any balance is recognized ratably over the remaining research term. Revenue recognition related to license fees, up-front payments and milestone payments could be accelerated in the event of early termination of programs.

The Company reports revenue for lead generation and lead optimization research, custom synthesis and process research, the development and sale of chemical compounds and the co-development of proprietary drug candidates it out-licenses, as collaboration revenue. License and milestone revenue is combined and reported separately from collaboration revenue.

   Accounting for Share-Based Compensation

The Company follows the fair value method of accounting for share-based compensation arrangements in accordance with Financial Accounting Standards Board (“FASB”) Statement No. 123R, Share-Based Payment (“SFAS 123R”). The Company adopted SFAS 123R effective July 1, 2005 using the modified prospective method of transition. Under the modified prospective method of transition, compensation expense is recognized beginning with the effective date of adoption for all share-based payments (i) granted after the effective date of adoption and (ii) granted prior to the effective date of adoption and that remain unvested on the date of adoption. Share-based compensation arrangements covered by SFAS 123R currently include stock options granted under our Amended and Restated Stock Option and Incentive Plan (the “Option Plan”) and purchases of common stock by our employees at a discount to the market price during offering periods under our Employee Stock Purchase Plan (the “ESPP”).

Under SFAS 123R, the estimated fair value of share-based-compensation, including stock options granted under the Option Plan and purchases of common stock by employees at a discount to market price under the ESPP, is recognized as compensation expense. The estimated fair value of stock options is expensed on a straight-line basis over the expected term of the grant. Compensation expense for purchases under the ESPP is recognized based on the estimated fair value of the common stock during each offering period and the percentage of the purchase discount.

7




The Company recorded $1.2 million ($0.03 per share) and $1.7 million ($0.05 per share) of total share-based compensation expense for the three months ended September 30, 2006 and 2005, respectively. These charges had no impact on the Company’s reported cash flows. Share-based compensation expense is allocated among the following categories:

 

 

Three Months Ended

 

 

 

September 30,

 

 

 

2006

 

2005

 

 

 

 

 

 

 

Cost of revenue

 

$

329

 

$

525

 

Research and development for proprietary drug discovery

 

370

 

413

 

Selling, general and administrative expenses

 

503

 

808

 

Total

 

$

1,202

 

$

1,746

 

 

The Company has computed the estimated fair values of all share-based compensation using the Black-Scholes option pricing model and has applied the assumptions set forth in the following table.

 

 

Average
Risk-Free
Interest Rate

 

Dividend
Yield

 

Average
Volatility

 

Weighted-
AverageOption
Life (Years)

 

First three months of Fiscal Year 2007

 

4.67

%

0

%

72.7

%

6.2

 

First three months of Fiscal Year 2006

 

4.19

%

0

%

77.9

%

6.4

 

 

Beginning in fiscal year 2006, we calculated the estimated life of stock options granted using a “simplified” method, which is based on the average of the vesting term and the actual term of the option, as a result of guidance from the SEC as contained in Staff Accounting Bulletin No. 107 permitting the initial use of this method. During the fourth quarter of 2006, we conducted a detailed evaluation of historical unexercised employee stock options that resulted in an estimated stock option life that was directly comparable to that calculated under the simplified method described above. We determined expected volatility for the periods presented using the historical method, which is based on the daily historical trading data of our common stock from November 2000, the date of our initial public offering, through the last day of the applicable period. Management selected the historical method primarily because we have not identified a more appropriate method to predict future volatility.

The Black-Scholes option pricing model requires the input of highly subjective assumptions. Because the Company’s employee stock options have characteristics significantly different from those of traded options, and because changes in the subjective input assumptions can materially affect the fair value estimate, in management’s opinion, the existing models may not provide a reliable single measure of the fair value of its employee stock options or common stock purchased under the Employee Stock Purchase Plan. In addition, management will continue to assess the assumptions and methodologies used to calculate estimated fair value of share-based compensation. Circumstances may change and additional data may become available over time, which may result in changes to these assumptions and methodologies, which could materially impact the Company’s fair value determination.

8




A summary of activity in the Option Plan for the period ended September 30, 2006 is as follows:

 

 

Number of
Option Shares

 

Weighted-
Average
Exercise Price

 

Outstanding Balance, June 30, 2006

 

7,595,492

 

$

6.63

 

Granted

 

388,290

 

8.33

 

Exercised

 

(48,499

)

3.31

 

Forfeited or expired

 

(38,448

)

7.70

 

Outstanding Balance, September 30, 2006

 

7,896,835

 

6.73

 

 

 

 

 

 

 

Exercisable shares as of September 30, 2006

 

4,965,657

 

6.64

 

 

As of September 30, 2006, there was $10.1 million of unrecognized compensation expense related to unvested share-based compensation arrangements granted under the Option Plan. This expense is expected to be recognized as follows:

 

Fiscal Year 2007 - remaining periods

 

$

3,063

 

Fiscal Year 2008

 

3,356

 

Fiscal Year 2009

 

2,319

 

Fiscal Year 2010

 

1,303

 

Fiscal Year 2011

 

75

 

 

 

$

10,116

 

 

   Comprehensive Loss

A reconciliation of net loss to comprehensive income (loss) is as follows:

 

 

Three Months Ended

 

 

 

September 30,

 

 

 

2006

 

2005

 

 

 

 

 

 

 

Net loss

 

$

(8,231

)

$

(9,672

)

Change in unrealized gain (loss) on marketable securities

 

174

 

(108

)

Total comprehensive loss

 

$

(8,057

)

$

(9,780

)

 

   Net Loss Per Share

Basic and diluted net loss per share has been computed by dividing net loss for the period by the weighted average number of common shares outstanding during the period. The Company has excluded the effects of outstanding stock options from the calculation of diluted net loss per share because all such securities are anti-dilutive for all periods presented. The number of common share equivalents relating to these stock options excluded from the diluted loss per share calculations for the three months ended September 30, 2006 was 1,398,998 shares. For the three months ended September 30, 2005, the number of common share equivalents was 1,472,035 shares.

9




   Use of Management’s Estimates

The preparation of financial statements in conformity with U.S. generally accepted accounting principles requires management to make certain estimates and assumptions that affect the amounts reported in the financial statements and accompanying notes. Actual results could differ from those estimates.

Note 2: Cash, Cash Equivalents and Marketable Securities

Cash, cash equivalents and marketable securities classified as available-for-sale as of September 30, 2006 and June 30, 2006 consist of the following:

 

 

September 30,

 

June 30,

 

 

 

2006

 

2006

 

Cash and cash equivalents:

 

 

 

 

 

Cash

 

$

709

 

$

449

 

Money market fund

 

4,958

 

15,119

 

Repurchase agreements

 

8,077

 

 

Total

 

$

13,744

 

$

15,568

 

 

 

 

 

 

 

Marketable securities:

 

 

 

 

 

Auction rate securities

 

$

37,981

 

$

17,528

 

Federal agency mortgage-backed securities

 

44,115

 

37,004

 

Total

 

$

82,096

 

$

54,532

 

 

Debt securities at September 30, 2006 and June 30, 2006 are shown below by contractual maturity. Actual maturities may differ from contractual maturities because issuers of the securities may have the right to prepay obligations. The near-term reset dates are used as the implied maturity dates for classifying Auction rate securities below.

 

 

September 30,

 

June 30,

 

 

 

2006

 

2006

 

Marketable securities:

 

 

 

 

 

Due in one year or less

 

$

70,561

 

$

44,132

 

Due after one year through two years

 

11,535

 

10,400

 

Total

 

$

82,096

 

$

54,532

 

 

The Company has included marketable securities due after one year within current assets, as these investments are available for use in current operating activities.

Note 3: Inventory Components

 

 

September 30,

 

June 30,

 

 

 

2006

 

2006

 

 

 

 

 

 

 

Fine chemicals

 

$

1,809

 

$

1,857

 

Optimer building blocks

 

2,008

 

2,009

 

Total inventories at cost

 

3,817

 

3,866

 

Less reserves

 

(2,211

)

(2,221

)

Total inventories, net

 

$

1,606

 

$

1,645

 

 

 

10




Note 4: Long Term Debt

The Company entered into a Loan and Security Agreement (“Loan and Security Agreement”) with Comerica Bank (“Bank”) dated June 28, 2005, as amended. The Loan and Security Agreement provides for a term loan, equipment advances and a revolving line of credit, all of which are secured by a security interest in the Company’s assets, other than its intellectual property. The full $10 million term loan was advanced to the Company on June 30, 2005. As of September 30, 2006, the Company had received the full $5 million allotment of equipment advances which were used to finance the purchase of equipment, capitalized software and tenant improvements over the past five fiscal quarters. Interest on these loans, currently having an interest rate of 6.5% per annum, is payable in monthly installments, with a balloon payment of $15 million due on June 28, 2010.

On July 7, 2006, the Company entered into a Second Amendment to the Loan and Security Agreement (“Second Amendment”) with the Bank. The Second Amendment increased the combined letters of credit under the revolving loan commitment to a maximum of $6.75 million.  During the period ended September 30, 2006, standby letters of credit were issued in relation to the Company’s facilities leases in the amount of $6.7 million.  These standby letters of credit expire on August 31, 2016.  In addition, under the Second Amendment, the specified minimum cash balances to be maintained at the Bank were modified. In accordance with the Second Amendment, if the Company’s total cash, cash equivalents and marketable securities, including those invested at the Bank, falls below $40 million, between $30 million and $27.5 million, or below $27.5 million, the minimum required balance maintained at the Bank shall be $2 million, $13 million or $24 million, respectively.

The Loan and Security Agreement contains representations and warranties and affirmative and negative covenants that are customary for credit facilities of this type. The Loan and Security Agreement could restrict the Company’s ability to, among other things, sell certain assets, engage in a merger or change in control transaction, incur debt, pay cash dividends and make investments. The Loan and Security Agreement also contains events of default that are customary for credit facilities of this type, including payment defaults, covenant defaults, insolvency type defaults and events of default relating to liens, judgments, material misrepresentations and the occurrence of certain material adverse events.

Note 5: Operating Leases

Assignment and Facility Lease Agreements. On June 22, 2006, the Company entered into a series of agreements involving the assignment to BioMed Reality L.P. (“BioMed”) of options it acquired to purchase the facilities that it occupied in Boulder and Longmont, Colorado and the subsequent lease of those facilities from BioMed. Pursuant to an Assignment Agreement dated June 22, 2006 between Array and BioMed (the “Assignment Agreement”), BioMed agreed to purchase these facilities in both Boulder and Longmont and the Company assigned the option to purchase these facilities to BioMed for a total of $30.5 million, payable upon the purchase of the Boulder and Longmont facilities by BioMed.

On July 7, 2006, BioMed completed the purchase of the Boulder facility as contemplated by the Assignment Agreement (the “Boulder Closing”) and paid the Company a total of $16.5 million pursuant to the Assignment Agreement. As part of the transactions contemplated by the Assignment Agreement, the Company also entered into a lease agreement with BioMed, dated July 7, 2006, for the Boulder facility (the “Boulder Lease”). The Boulder Lease has a term of 10 years with an initial rental rate of $4.8 million annually, subject to 2% annual increases, with the right to extend for up to two additional five-year terms. In addition, the Company received a tenant improvement allowance of $1.7 million under the Boulder Lease . Upon the Boulder Closing, the existing sublease with Amgen and the related lease agreements with the landlord terminated.

On August 9, 2006, BioMed completed the purchase of the Longmont facility as contemplated by the Assignment Agreement (the “Longmont Closing”) and paid the Company a total of $14.0 million pursuant to the Assignment Agreement. As part of the transactions contemplated by the Assignment Agreement, the Company also entered into a lease agreement with BioMed, dated August 9, 2006, for the Longmont facility (the “Longmont Lease”). The Longmont Lease has a term of 10 years with an initial rental rate of $2.2 million annually, subject to 2% annual increases, with the right to extend for up to two additional five-year terms. In addition, the Company received a tenant improvement allowance of $300,000 under the Longmont Lease . Upon the Longmont Closing, the prior lease agreements for the Longmont facility terminated.

11




The Company recorded the combined net proceeds from BioMed of $32.3 million, net of approximately $200,000 in transaction-related costs, as deferred rent. For more information see Note 1: “Deferred Rent”.

Note 6: Segment, Geographic and Concentration Information

All operations of the Company are considered to be in one operating segment and, accordingly, no segment disclosures have been presented. The physical location of the Company’s property, plant and equipment is within the United States. The following table details revenue from customers by geographic area based on the country in which collaborators are located or the destination where compounds from the Company’s inventories are shipped.

 

 

Three Months Ended
September 30,

 

 

 

2006

 

2005

 

 

 

(in thousands)

 

 

 

 

 

 

 

North America

 

$

6,368

 

$

6,970

 

Europe

 

3,084

 

3,514

 

Japan and Asia-Pacific

 

1,574

 

758

 

Total revenue

 

$

11,026

 

$

11,242

 

 

Approximately 97% and 94% of the revenue generated from Europe during the three months ended September 30, 2006 and 2005, respectively, is related to the Company’s collaboration and licensing agreement with AstraZeneca AB, located in Sweden. For the three months ended September 30, 2006, revenue generated primarily from two Japanese customers represented 14% of total revenue. No other individual international country exceeded 10% of the Company’s revenue for the period presented.

During the three months ended September 30, 2006, revenue from four of the Company’s customers represented approximately 34%, 27%, 22% and 11% of total revenue, while three of the Company’s customers represented approximately 31%, 29% and 18% of total revenue for the comparative period in fiscal 2006.

Note 7: Recent Accounting Pronouncements

The Company believes that the adoption of all recently issued accounting pronouncements will have no impact on its financial condition or results of operations.

12




Item 2.  Management’s Discussion and Analysis of Financial Condition and Results of Operations

The Management’s Discussion and Analysis of Financial Condition and Results of Operations contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995, including statements about our expectations related to realizing new revenue streams and obtaining future collaboration agreements that include milestone and/or royalty payments, the success of our internal proprietary drug discovery activities, the expected level of our investment in proprietary research and our future headcount and capital expenditure requirements. These statements involve significant risks and uncertainties, including those discussed below and those described more fully in other reports filed by Array BioPharma with the Securities and Exchange Commission. Because these statements reflect our current expectations concerning future events, our actual results could differ materially from those anticipated in these forward-looking statements. The factors that could cause actual results to differ from our expectations include, but are not limited to, our ability to achieve and maintain profitability, the extent to which the pharmaceutical and biotechnology industries are willing to in-license drug candidates for their product pipelines and to collaborate with and fund third parties on their drug discovery activities, our ability to out-license our proprietary candidates on favorable terms, our ability to continue to fund and successfully progress internal research efforts and to create effective, commercially viable drugs, risks associated with our dependence on our collaborators for the clinical development and commercialization of our out-licensed drug candidates, the ability of our collaborators and of Array to meet objectives, including clinical trials, tied to milestones and royalties, our ability to attract and retain experienced scientists and management, and the risk factors contained in the Annual Report on Form 10-K filed by Array with the Securities and Exchange Commission (“SEC”) on September 1, 2006. We are providing this information as of the date of this report. We undertake no duty to update any forward-looking statements to reflect the occurrence of events or circumstances after the date of such statements or of anticipated or unanticipated events that alter any assumptions underlying such statements.

 The following discussion of our financial condition and results of operations should be read in conjunction with the financial statements and notes to those statements included elsewhere in this report.

Overview

Array BioPharma is a biopharmaceutical company focused on the discovery, development and commercialization of targeted small molecule drugs to treat life threatening and debilitating diseases. Our proprietary drug development pipeline is primarily focused on the treatment of cancer and inflammatory disease and includes clinical candidates that are designed to regulate therapeutically important targets. In addition, leading pharmaceutical and biotechnology companies collaborate with Array to discover and develop drug candidates across a broad range of therapeutic areas.

We have identified multiple drug candidates in our own proprietary programs and in collaborations with other drug companies. We intend to progress our proprietary drug programs internally through clinical testing and continue to evaluate select programs for out-licensing opportunities with pharmaceutical and biotechnology partners.

We have built our drug development pipeline, and our discovery and development capabilities, primarily through cash flow from collaborations and through sales of our equity securities. Through September 30, 2006, we have recognized $201.3 million in collaboration revenue, and we have received $18.2 million in up-front payments and $12.5 million in milestone payments from our collaborators and out-licensing partners. Under our existing collaboration agreements, we have the potential to earn over $200.0 million in additional milestone payments if we achieve all of the drug discovery objectives under these agreements, as well as royalties on any resulting product sales from 15 different programs.

We have incurred net losses since inception and expect to incur losses in the near future as we continue to invest in our proprietary drug discovery programs. As of September 30, 2006, we had an accumulated deficit of $141.9 million.

Revenue . We generate revenue through the out-licensing of select proprietary drug discovery programs for license and up-front fees, research funding based on the number of full-time equivalents contractually assigned to the program, and research and development milestone payments. We also have the potential to generate revenue from royalties on future product sales. Four programs have been out-licensed to date to AstraZeneca, Genentech, Inc. and Amgen Inc., and we have received up-front license fees of $18.2 million in total for these programs.

13




We also generate revenue through collaborations aimed at inventing drug candidates for our collaborators. We receive research funding based on the number of full-time equivalent employees contractually assigned to a program, plus related research expenses. Under certain of these agreements, we are entitled to receive additional payments based on the achievement of research milestones, drug development milestones and/or royalty payments based on sales of products created as a result of these collaborations.

We sell our Optimer â  building blocks, which are the starting materials used to create more complex chemical compounds in the drug discovery process, on a per-compound basis without any restrictions on use. In addition, we have licensed our Lead Generation Libraries, which are a collection of structurally related chemical compounds that may have the potential of becoming drug candidates, on a non-exclusive basis to our collaborators for their internal research purposes. We are no longer developing new Lead Generation Libraries other than for our proprietary research and expect future revenue from sales of compounds in our Lead Generation Libraries to be insignificant.

We report revenue for lead generation and lead optimization research, custom synthesis and process research, the development and sale of chemical compounds and the co-development of proprietary drug candidates we out-license, as collaboration revenue. License and milestone revenue is combined and reported separately from collaboration revenue.

Revenue Recognition. We recognize revenue under our collaboration agreements on a monthly basis as work is performed. Per-compound revenue is recognized as compounds are shipped. Revenue from license fees and up-front fees is recognized on a straight-line basis over the expected period of the related research program. Payments received in advance of performance are recorded as advance payments from collaborators until the revenue is earned. Milestone payments are non-refundable and are recognized as revenue over the expected period of the related research program. A portion of each milestone payment is recognized when the milestone is achieved based on the applicable percentage of the research term that has elapsed. Any balance is recognized ratably over the remaining research term. Revenue recognition related to license fees, up-front payments and milestone payments could be accelerated in the event of early termination of programs.

Customer Concentration. Our top 10 collaborators contributed approximately 99% of our total revenue for the first three months of fiscal 2007, and our current top four collaborators, Genentech, AstraZeneca,  InterMune, Inc. and Ono Pharmaceutical Co., Ltd., accounted for 34%, 27%, 22%, and 11%, respectively, of our total revenue. During the same period of fiscal year 2006, Genentech, AstraZeneca and InterMune, accounted for 31%, 29%, and 18%, respectively, of our total revenue.  In general, our collaborators may terminate their collaboration agreements with us on 90 to 120 days’ prior notice.

International Revenue. International revenue represented 42% of our total revenue during the first three months of fiscal year 2007, up from 38% for the same period in the prior year. Our international revenue is primarily attributable to European and Japanese collaborations. International revenue increased in the first three months of fiscal year 2007 over the comparable prior year period due to a $3.0 million milestone payment received from AstraZeneca combined with revenue generated from a Japanese research collaboration with Ono that began in November 2005. All of our collaboration agreements are denominated in United States dollars.

Cost of Revenue. Cost of revenue represents research and development conducted for our collaborators and the cost of chemical compounds sold from our inventory. These costs consist mainly of compensation, associated fringe benefits and other collaboration-related costs, supplies, small tools, facilities, depreciation, recruiting and relocation and other direct and indirect laboratory support costs. Fine chemicals consumed as well as any required inventory reserve adjustments are also recorded as cost of revenue. We review the levels and values of our chemical inventories periodically and, when required, write down the carrying cost of our inventories for non-marketability to estimated net realizable value through an appropriate reserve.

Research and Development Expenses for Proprietary Drug Discovery. Research and development expenses for proprietary drug discovery consists of all costs associated with our proprietary drug development pipeline, including compensation and fringe benefits, consulting and outsourced services, laboratory supplies, and allocated facility costs and depreciation. When an internal proprietary program is out-licensed, all subsequent costs of the out-licensed program are reported as cost of revenue.

14




Selling, General and Administrative Expenses. Selling, general and administrative expenses consist mainly of compensation and associated fringe benefits not included in cost of revenue or research and development expenses and include other management, business development, accounting, information technology and administration costs, including patent prosecution, recruiting and relocation, consulting and professional services, travel and meals, advertising, sales commissions, facilities, depreciation and other office expenses.

Business Development. We currently license our compounds and enter into collaborations directly with pharmaceutical and biotechnology companies through opportunities identified by our business development group, senior management, scientists and customer referrals. In addition, we license our compounds and enter into collaborations in Japan through an agent. The financial relationship with our Japanese agent represents a de minimis percent of any generated revenue.

Future Outlook . We plan to increase our investment in proprietary research to broaden our product pipeline and to further enhance our clinical and regulatory capabilities to allow us to advance drugs further in clinical development. We will consider commercializing select programs ourselves with appropriate market characteristics while continuing to evaluate out-licensing opportunities to maximize the risk-adjusted return of our proprietary programs. As part of these efforts, we expect near term selling, general and administrative costs to rise in connection with increased patent and other intellectual property related costs incurred to protect and enforce our intellectual property rights in our proprietary programs. We also expect research and development for proprietary drug discovery costs to rise in connection with building our clinical and regulatory capabilities.  As we devote more scientists to our proprietary research, we expect fewer scientists will be assigned to revenue generating collaborations. Because of our strategy to retain other proprietary programs later in clinical development before out-licensing them or commercializing them ourselves, we may not recognize significant revenue from new out-licensing opportunities in the near term. Our statements about future events in this paragraph are subject to many risks and uncertainties, including many that are beyond our control. These risks are described more fully under the caption “Risk Factors” included in our annual report on Form 10-K filed with the SEC on September 1, 2006, and in other reports we file with the SEC.

Results of Operations

Three Months Ended September 30, 2006 and 2005

Revenue. Collaboration revenue decreased by approximately $295,000 for the three months ended September 30, 2006, over the same period in the prior year. This decline was primarily the result of decreased collaboration revenue of $2.4 million from research programs that expired with AstraZeneca and Eli Lilly and Company and under one of our programs with Takeda Chemical Industries, Ltd. Additionally, collaboration revenue from the sale of Lead Generation Libraries and Optimer building blocks decreased by approximately $437,000 during the period. Partially offsetting these decreases was increased revenue of $2.5 million from expanded programs with Genentech and InterMune and a new research collaboration with Ono.

License and milestone revenue increased by approximately $79,000 during the three months ended September 30, 2006, over the same period of the prior year. This increase was due to the recognition of a $3.0 million milestone payment received from AstraZeneca related to advancing ARRY-886 into Phase 2 clinical trials. This increase was largely offset by decreased revenue from previously received license fee and milestone payments from AstraZeneca and Genentech that were fully recognized in November 2005.

Share-Based Compensation . We follow the fair value method of accounting for share-based compensation arrangements in accordance with FASB Statement No. 123R, Share-Based Payment — an amendment of FASB Statement No. 123 and 95 (“SFAS 123R”). We adopted SFAS 123R effective July 1, 2005 using the modified prospective method of transition. We recorded $1.2 million ($0.03 per share) and $1.7 million ($0.05 per share) of share-based compensation expense for the three months ended September 30, 2006 and 2005, respectively. This amount is allocated among cost of revenue, research and development expenses for proprietary drug discovery and selling, general and administrative expenses based on the function of the related employee. This charge had no impact on our reported cash flows for the periods presented. For more information about the adoption of SFAS 123R, see Note 1: “Summary of Significant Accounting Policies — Accounting for Share-Based Compensation” to the Unaudited Notes to Condensed Financial Statements included in this Form 10-Q, as well as the section below entitled “Critical Accounting Policies — Share-Based Compensation”.

 

15




Cost of Revenue. Cost of revenue decreased by $3.1 million, or 33%, during the three months ended September 30, 2006 over the same period of the prior year. Decreased cost of revenue as a percentage of collaboration revenue of 78% in the first quarter of fiscal 2007 compared to 113% in the same period of the prior year is largely the result of increased average pricing received from collaborations resulting in fewer scientific resources used in generating the similar level of revenue.

On June 22, 2006, we assigned options we owned to purchase our Boulder and Longmont, Colorado facilities to BioMed Realty L.P. (“BioMed”), which purchased those facilities in July and August 2006. We entered into new lease agreements for these facilities with BioMed over a ten-year lease term and began amortizing our leasehold improvement costs for these facilities over a ten-year life. (For more information see Note 5:”Operating Leases”, to the Unaudited Notes to Condensed Financial Statements) . Prior to completing these transactions, we had determined that we were reasonably assured during fiscal 2006 that we would be vacating our Boulder facility at the end of the initial lease term in March 2008 and therefore amortized the cost of leasehold improvements for that facility over an approximate two-year life. This change in estimated useful life resulted in a decrease of approximately $190,000 in amortized leasehold improvement costs being charged to cost of revenue for the first quarter of fiscal 2007. This quarterly difference is expected to continue for the remainder of the fiscal year compared to the same periods of the prior year.

Following termination of our prior facility leases and execution of new lease agreements with BioMed in July and August 2006, we reversed and recorded the entire deferred rent balance of $1.6 million, listed as a current liability on June 30, 2006, as a reduction to our recognized rent expense for the first quarter of fiscal 2007, resulting in a decrease to cost of revenue of approximately $600,000. Additionally, share-based compensation expense charged to cost of revenue for the period ended September 30, 2006, decreased by approximately $200,000 due to option shares that became fully vested in the prior fiscal year.

Research and Development Expenses for Proprietary Drug Discovery. Research and development expenses for proprietary drug discovery increased by $2.2 million, or 26%, during the three months ended September 30, 2006, over the same period of the prior year. This increase was primarily due to additional scientists and increased pharmacology studies supporting our expanded efforts to advance proprietary compounds into regulated safety testing and clinical trials. The most significant increase in costs came from outsourced pharmacology studies and clinical trial related expenses supporting the advancement of our ErB2/EGFR, Mek for inflammation, P38, KSP and other programs. We expect that proprietary research and development spending will continue to increase as we focus more resources on our proprietary drug discovery and development programs and advance our programs potentially through clinical development. As described in cost of revenue above, the change in estimated useful life of our leasehold improvements resulted in a reduction of the amortization of leasehold improvement costs being charged to research and development expenses for proprietary drug discovery for the period ended September 30, 2006 by approximately $230,000. This quarterly difference is expected to continue for the remainder of the fiscal year compared to the same periods of the prior year. Additionally, the reversal of the prior year deferred rent balance, described in cost of revenue above, resulted in a reduction to rent expense allocated to research and development expenses for proprietary drug discovery of approximately $850,000.

Selling, General and Administrative Expenses. Selling, general and administrative expenses decreased by approximately $485,000 or 14% during the three months ended September 30, 2006, over the same period of the prior year. The decrease was primarily the result of decreased share-based compensation expense of approximately $305,000 related to option shares that became fully vested in the prior fiscal year. As described in cost of revenue above, the change in estimated useful life of our leasehold improvements resulted in a reduction of the amortization of leasehold improvement costs being charged to selling, general and administrative expenses for the period ended September 30, 2006 by approximately $40,000. This quarterly difference is expected to continue for the remainder of the fiscal year compared to the same periods of the prior year. Additionally, the reversal of the prior year deferred rent balance, described in cost of revenue above, resulted in a reduction to rent expense allocated to selling, general and administrative expenses of approximately $100,000.

Interest Expense. Interest expense increased to approximately $240,000 for the three months ended September 30, 2006 from approximately $129,000 in the same period of the prior year due to higher interest rates charged on a higher outstanding long term debt balance.

16




Interest Income. Interest income increased to $1.1 million for the three months ended September 30, 2006 from approximately $684,000 in the same period of the prior year due to higher investment interest rates earned on higher average cash and investment balances.

Liquidity and Capital Resources

We have historically funded our operations through revenue from our collaborations and the issuance of equity securities. As of September 30, 2006, cash, cash equivalents and marketable securities totaled $95.8 million compared with $70.1 million at June 30, 2006.

Net cash used in operating activities was $6.9 million for the three months ended September 30, 2006 compared to $9.0 million in the same period of the prior year. During the first three months of fiscal year 2007, our net loss of $8.2 million was reduced by noncash charges of approximately $782,000 associated with depreciation, share-based compensation expense and deferred rent credits. For the first three months of fiscal year 2007 our net operating assets and liabilities, excluding cash, decreased by approximately $553,000. This was primarily due to decreases in accounts receivable balances and increases in accrued compensation and benefits which were slightly offset by decreases in accounts payable balances and advance payments from collaborators. Accounts receivable balances decreased by $1.2 million due to the timing of receipts from our customers while accounts payable balances decreased by approximately $751,000 due to lower outstanding amounts to vendors for various laboratory equipment and supplies. Accrued compensation and benefits increased by approximately $944,000 partially due to amounts reserved for fiscal year 2007 planned employee bonuses as well as approximately $200,000 related to employee payroll withholdings for the Employee Stock Purchase Plan. Advance payments from collaborators decreased by approximately $660,000 due to the recognition of revenue from previously received customer deposits.

During the three months ended September 30, 2006, we received net proceeds of $32.3 million from BioMed related to the assignment of purchase options of our Boulder and Longmont, Colorado facilities. We invested approximately $860,000 in laboratory equipment, primarily for biology and analytical research and development operations, as well as in various computer hardware and software. Purchases of marketable securities used $39.4 million, while proceeds from the sale and maturity of marketable securities provided $12.0 million. Financing activities provided $1.0 million consisting of approximately $850,000 from the issuance of long term debt used to finance purchases of capital equipment and approximately $197,000 resulting from the exercise of stock options under our stock option plan.

As of September 30, 2006, we had a $10 million term loan and $5 million of equipment advances outstanding under our Loan and Security Agreement with Comerica Bank, which currently bear interest at the rate of 6.5% per annum. Interest on the loans is payable in monthly installments. A balloon payment of $15 million is due at maturity of the loans on June 28, 2010. We also have a revolving line of credit in the amount of $6.75 million to support outstanding standby letters of credit that have been issued in relation to our facilities leases. These standby letters of credit will expire on August 31, 2016.

Our future capital requirements will depend on a number of factors, including the rate at which we invest in proprietary research, the growth of our collaboration business and the amount of collaboration research funding we receive, the timing of milestone and royalty payments, if any, from our collaboration and out-licensed programs, our capital spending on new facilities and equipment, expenses associated with unforeseen litigation, regulatory changes, competition, technological developments, general economic conditions and the extent to which we acquire or invest in other businesses, products and technologies.

In addition, our future capital requirements may be impacted if we do not receive potential milestone or royalty payments under our existing or future collaboration agreements. Our ability to realize these payments is subject to a number of risks, many of which are beyond our control and include the following: the drug development process is risky and highly uncertain, and we or our collaborators may not be successful in commercializing drug candidates we create; our collaborators have substantial control and discretion over the timing and continued development and marketing of drug candidates we create; the sale and manufacture of drug candidates we develop may not obtain regulatory approval; and, if regulatory approval is received, drugs we develop will remain subject to regulation or may not gain market acceptance, which could delay or prevent us from generating milestone or royalty revenue from the commercialization of these drugs.

17




We believe that our existing cash, cash equivalents and marketable securities and anticipated cash flow from existing collaboration agreements will be sufficient to support our current operating plan for at least the next 12 months. This estimate of our future capital requirements is a forward-looking statement that is based on assumptions that may prove to be wrong and that involve substantial risks and uncertainties. Our actual future capital requirements could vary as a result of a number of factors, including:

·                   the progress of our research activities;

·                   our ability to enter into agreements to out-license and co-develop our proprietary drug candidates, and the timing of those agreements in each candidate’s development stage;

·                   the number and scope of our research programs;

·                   the progress of our preclinical and clinical development activities;

·                   the number and scope of phase 2 studies we may decide to run;

·                   the progress of the development efforts of our collaborators;

·                   the availability of resources for revenue generating collaborations as we devote more resources to our proprietary programs;

·                   our ability to establish and maintain current and new collaboration agreements;

·                   the ability of our collaborators to fund research and development programs;

·                   the costs involved in enforcing patent claims and other intellectual property rights;

·                   the costs and timing of regulatory approvals; and

·                   the costs of establishing clinical development and distribution or commercialization capabilities.

Until we can generate sufficient levels of cash from our operations, which we do not expect to achieve in the foreseeable future, we expect to continue to utilize our existing cash and marketable securities resources that were primarily generated from the proceeds of our equity offerings. In addition, we may finance future cash needs through the sale of equity securities, strategic collaboration agreements and debt financing. We cannot assure that we will be successful in obtaining new or in retaining existing out-license or collaboration agreements, in securing agreements for the co-development of our proprietary drug candidates, or in receiving milestone and/or royalty payments under those agreements, that our existing cash and marketable securities resources will be adequate or that additional financing will be available when needed or that, if available, this financing will be obtained on terms favorable to us or our stockholders. Insufficient funds may require us to delay, scale back or eliminate some or all of our research or development programs or to relinquish greater or all rights to product candidates at an earlier stage of development or on less favorable terms than we would otherwise choose, or may adversely affect our ability to operate as a going concern. If we raise additional funds by issuing equity securities, substantial dilution to existing stockholders may result.

Obligations and Commitments

The following table shows our contractual obligations and commitments as of September 30 , 2006.

 

 

 

Payments due by period

 

 

Less than
1 year

 

1-3 years

 

4-5 years

 

After 5
years

 

Total

 

 

 

(in thousands)

 

Operating lease obligations

 

$

7,159

 

$

14,525

 

$

14,999

 

$

38,347

 

$

75,030

 

Purchase obligations

 

7,944

 

3,095

 

13

 

 

11,052

 

Debt obligations (including interest, using current rate of 6.5%)

 

975

 

1,950

 

15,731

 

 

18,656

 

Total obligations

 

$

16,078

 

$

19,570

 

$

30,743

 

$

38,347

 

$

104,738

 

 

We are obligated under noncancelable operating leases for our facilities and certain equipment. The original lease terms for our facilities are ten years, with renewal options for two additional five-year terms , and provide for annual 2% rent increases and generally require us to pay a proportionate share of real estate taxes, insurance, common area and other operating costs. Equipment leases generally range from three to five years.

18




Purchase obligations totaling $11.1 million were primarily for outsourced pharmacology services, chemicals, laboratory equipment and supplies.

During the period ended September 30, 2006, standby letters of credit were issued in relation to our facilities leases in the amount of $6.7 million.  These standby letters of credit expire on August 31, 2016 and are fully supported by a revolving line of credit with Comerica Bank.

Critical Accounting Policies

We believe critical accounting policies are essential to the understanding of our results of operations and require our management to make significant judgments in preparing the financial statements included in this report. Management has made estimates and assumptions based on these policies. We do not believe that materially different amounts would be reported if different assumptions were used. However, the application of these policies involves judgments and assumptions as to future events and, as a result, actual results could differ. The impact and any associated risks related to these policies on our business operations is discussed throughout Management’s Discussion and Analysis of Financial Condition and Results of Operations where such policies affect our reported and expected financial results.

     Revenue Recognition

We believe our revenue recognition policy is significant because the amount and timing of revenue is a key component of our results of operations. We follow the guidance of Staff Accounting Bulletin No. 104, which requires that a series of criteria be met in order to recognize revenue related to the performance of services or the shipment of products. If these criteria are not met, the associated revenue is deferred until the criteria are met. We recognize revenue when (a) persuasive evidence of an arrangement exists, (b) products are delivered or services are rendered, (c) the sales price is fixed or determinable and (d) collectibility is assured.

Most of our revenue is derived from designing, creating, optimizing, evaluating and developing drug candidates for our collaborators. The majority of our collaboration revenue consists of fees received based on contracted annual rates for full time equivalent employees working on a project. Our collaboration agreements also include license and up-front fees, milestone payments upon achievement of specified research or development goals and royalties on sales of resulting products. A small portion of our revenue comes from fixed fee agreements and from sales of compounds on a per-compound basis.

Our collaboration agreements typically call for a specific level of resources as measured by the number of full time equivalent scientists working a defined number of hours per year at a stated price under the agreement. We recognize revenue under our collaboration agreements on a monthly basis as work is performed. We recognize revenue from sales of Lead Generation Library and Optimer building block compounds as the compounds are shipped, as these agreements are priced on a per-compound basis and title and risk of loss passes upon shipment to our customers.

Revenue from license fees and up-front fees is non-refundable and is recognized on a straight-line basis over the expected period of the related research program. Milestone payments are non-refundable and are recognized as revenue over the expected period of the related research program. A portion of any milestone payment is recognized at the date the milestone is achieved which is determined using the applicable percentage of the research term that has elapsed at the date the milestone is achieved. Any balance is recognized ratably over the remaining research term. Revenue recognition related to license fees, up-front payments and milestone payments could be accelerated in the event of early termination of programs.

In general, contract provisions include predetermined payment schedules or the submission of appropriate billing detail. Payments received in advance of performance are recorded as advance payments from collaborators until the revenue is earned.

We report revenue for lead generation and lead optimization research, custom synthesis and process research, the development and sale of chemical compounds and the co-development of proprietary drug candidates we out-license, as collaboration revenue. License and milestone revenue is combined and reported separately from collaboration revenue.

19




     Share-Based Compensation

During the first quarter of fiscal 2006, we adopted the fair value method of accounting for share-based awards using the modified-prospective method of transition as outlined in Financial Accounting Standards Board Statement No. 123R, Share-Based Payment (“SFAS 123R”). Under SFAS 123R, the estimated fair value of share-based-compensation, including stock options granted under our Stock Option Plan and purchases of common stock by employees at a discount to market price under the Employee Stock Purchase Plan (“the ESPP”), is recognized as compensation expense. The estimated fair value of stock options is expensed on a straight-line basis over the expected term of the grant. Compensation expense for purchases under the ESPP is recognized based on the estimated fair value of the common stock during each offering period and the percentage of the purchase discount.

Under SFAS 123R, we use the Black-Scholes option pricing model to estimate the fair value of the share-based awards as of the grant date. The Black-Scholes model, by its design, is highly complex, and dependent upon key data inputs estimated by management. The primary data inputs with the greatest degree of judgment are the estimated lives of the share-based awards and the estimated volatility of our stock price. The Black-Scholes model is highly sensitive to changes in these two data inputs. We calculated the estimated life of stock options granted using a “simplified” method, which is based on the average of the vesting term and the term of the option, as a result of guidance from the SEC as contained in Staff Accounting Bulletin No. 107 permitting the initial use of this method. During the fourth quarter of 2006, we conducted a detailed evaluation of historical unexercised employee stock options that resulted in an estimated stock option life that was directly comparable to that calculated under the simplified method described above. We determined expected volatility for using the historical method, which is based on the daily historical trading data of our common stock from November 2000, the date of our initial public offering, through the last day of the applicable period. Management selected the historical method primarily because we have not identified a more reliable or appropriate method to predict future volatility. For more information about the adoption of SFAS 123R, see Note 1: “Summary of Significant Accounting Policies — Accounting for Share-Based Compensation” to the Unaudited Notes to Condensed Financial Statements included in this Form 10-Q.

Recent Accounting Pronouncements

We believe that the adoption of all recently issued accounting pronouncements will have no impact on our financial condition or results of operations.

Item 3. Quantitative and Qualitative Disclosures About Market Risk

Interest Rate Risk . Our interest income is sensitive to changes in the general level of United States interest rates, particularly since a significant portion of our investments are and will be in short term marketable securities. Due to the nature and short term maturities of our short term investments, we have concluded that there is no material market risk exposure. Based on outstanding investment balances at September 30, 2006, a change of 100 basis points in interest rates would result in a change in our annual interest income of approximately $958,000.

We are also impacted by adverse changes in interest rates relating to variable-rate borrowings under our credit facility. We pay interest on advances under our loan agreement at one of three variable rates, which are adjusted periodically for changes in the underlying prevailing rate. Changes in prevailing interest rates will not affect the fair value of our debt, but would impact future results of operations and cash flows. At September 30, 2006, we had $15 million of long term debt outstanding and the interest rate on our term loan and equipment advances was 6.5%. This rate is adjusted based on changes in the bank’s prime lending rate. Assuming constant debt levels, a change of 100 basis points in our interest rate would result in a change in our annual interest expense of approximately $150,000.

Foreign Currency Rate Fluctuations. All of our collaboration agreements and purchase orders are denominated in United States dollars. Therefore, we are not exposed to direct changes in foreign currency exchange rates.

Inflation . We do not believe that inflation has had a material impact on our business or operating results during the periods presented.

 

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Item 4. Controls and Procedures

Under the supervision and with the participation of our Chief Executive Officer, Chief Financial Officer and other senior management personnel, we evaluated the effectiveness of the design and operation of our disclosure controls and procedures (as defined in Rules 13a-15(e) and 15d-15(e) under the Securities Exchange Act of 1934). Based on that evaluation, our Chief Executive Officer and Chief Financial Officer have concluded that these disclosure controls and procedures as of September 30, 2006 are effective in recording, processing, summarizing and reporting the financial results of the Company’s operations. There were no changes in our internal controls and procedures over financial reporting during the quarter ended September 30, 2006 that have materially affected, or are reasonably likely to materially affect, the internal control over financial reporting.  

 

PART II

Item 6. Exhibits

(a)                                   Exhibits

10.1

 

Lease Agreement by and between Registrant, as Tenant, and BMR-3200 Walnut Street LLC, as Landlord, dated July 7, 2006

10.2

 

Lease Agreement by and between Registrant, as Tenant, and BMR-Trade Centre Avenue LLC, as Landlord, dated August 9, 2006

10.3

 

Agreement of Purchase and Sale agreement between Registrant, as Purchaser, and Circle Capital Longmont LLC, as Seller, dated August 9, 2006

10.4

 

Assignment of Longmont Purchase Agreement between Registrant, as Assignor, BMR-Trade Centre Avenue LLC, as Assignee and Circle Capital Longmont LLC, as Seller, dated August 9, 2006

10.5

 

Second Amendment to Loan and Security Agreement by and between Registrant and Comerica Bank dated July 7, 2006

10.6

 

Exercise of Option to Extend Funding of Research FTEs dated August 31, 2006 to the Drug Discovery Collaboration Agreement by and between Registrant and InterMune, Inc., dated September 13, 2002

31.1

 

Certification of Robert E. Conway pursuant to Section 302 of the Sarbanes-Oxley Act of 2002

31.2

 

Certification of R. Michael Carruthers pursuant to Section 302 of the Sarbanes-Oxley Act of 2002

32.0

 

Certifications of Robert E. Conway and R. Michael Carruthers pursuant to Section 906 of the Sarbanes-Oxley Act of 2002


 

Items 1 through 5 of Part II are not applicable and have been omitted.

 

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SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of Boulder, State of Colorado.

 

 

ARRAY BIOPHARMA INC.

 

 

 

 

 

Dated: November 6, 2006

 

By:

/s/ Robert E. Conway

 

 

 

 

Robert E. Conway

 

 

 

 

Chief Executive Officer

 

 

 

 

 

 

Dated: November 6, 2006

 

By:

/s/ R. Michael Carruthers

 

 

 

 

R. Michael Carruthers

 

 

 

 

Chief Financial Officer

 

 

 

 

(Principal Financial and

 

 

 

 

Accounting Officer)

 

 

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Exhibit 10.1

EXECUTION VERSION

LEASE

by and between

BMR-3200 Walnut Street LLC,

a Delaware limited liability company]

and

Array BioPharma Inc.,

a Delaware corporation




LEASE

 

THIS LEASE (this “ Lease ”) is entered into as of this         day of             , 2006, by and between BMR-3200 Walnut Street LLC, a Delaware limited liability company (“ Landlord ”), and Array BioPharma Inc., a Delaware corporation (“ Tenant ”).

RECITALS

WHEREAS, Landlord owns certain real property (the “ Property ”) and the building improvements thereon located at 1885 33 rd  Street, 1825 33 rd  Street, 1865 33 rd  Street and 3200 Walnut Street, Boulder Colorado, including the buildings located thereon (the “ Building ”) in which the Premises (as defined below) are located; and

WHEREAS, Landlord wishes to lease to Tenant, and Tenant desires to lease from Landlord, the Premises (as defined below) pursuant to the terms and conditions of this Lease, as detailed below.

AGREEMENT

NOW, THEREFORE, Landlord and Tenant, in consideration of the mutual promises contained herein and for other good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, and intending to be legally bound, agree as follows:

1.              Lease of Premises . Landlord hereby leases to Tenant, and Tenant hereby leases from Landlord, the Premises, as shown on Exhibit A attached hereto.  The Property and all landscaping, parking facilities and other improvements and appurtenances related thereto, including, without limitation, the Building, are hereinafter collectively referred to as the “ Premises .”

2.              Basic Lease Provisions . For convenience of the parties, certain basic provisions of this Lease are set forth herein. The provisions set forth herein are subject to the remaining terms and conditions of this Lease and are to be interpreted in light of such remaining terms and conditions.

2.1.           This Lease shall take effect upon the date of execution and delivery hereof by all parties hereto and, except as specifically otherwise provided within this Lease, each of the provisions hereof shall be binding upon and inure to the benefit of Landlord and Tenant from the date of execution and delivery hereof by all parties hereto.

2.2.           Rentable Area of the Premises:  149,984 sq. ft., subject to adjustment pursuant to the terms hereof

2.3.           Initial Monthly Rental Installments of Basic Annual Rent:  149,984 s.f. x $30.00 per s.f. / 12 = $374,960, subject to adjustment pursuant to the terms hereof

2.4.           Initial Basic Annual Rent: 149,984 s.f. x $30.00 per s.f. = $4,499,520, subject to adjustment pursuant to the terms hereof

2.5.           Term Commencement Date:                                , 2006

2.6.           Term Expiration Date:                                         , 2016

2.7.           Security Deposit: $4,499,520

2.8.           Permitted Use:  General office and laboratory use in conformity with Applicable Laws (as defined below)

2.9.           Address for Rent Payment: BMR-3200 Walnut Street LLC, c/o BioMed Realty, L.P., 17190 Bernardo Center Drive, Suite 222, San Diego, California 92128, Attn:  Karen Sztraicher.

2.10.         Address for Notices to Landlord: BMR-3200 Walnut Street LLC, c/o BioMed Realty, L.P., 17190 Bernardo Center Drive, Suite 222, San Diego, California 92128, Attn: General Counsel

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2.11.         Address for Notices to Tenant: Array BioPharma Inc., 3200 Walnut Street, Boulder Colorado 80301, Attn: John Moore

2.12.         The following Exhibits are attached hereto and incorporated herein by reference:

 

Exhibit A

Premises

 

Exhibit B

Acknowledgement of Term Commencement Date and Term Expiration Date

 

Exhibit C

Tenant’s Personal Property

 

Exhibit D

Rules and Regulations

 

Exhibit E

Form of Estoppel Certificate

 

Exhibit F

Nonfunctional Equipment

 

3.              Term .

3.1.           This Lease shall take effect upon the date of execution and delivery hereof by all parties hereto and, except as specifically otherwise provided within this Lease, each of the provisions hereof shall be binding upon and inure to the benefit of Landlord and Tenant from the date of execution and delivery hereof by all parties hereto.

3.2.           The actual term of this Lease (the “ Term ”) shall be that period from the Term Commencement Date through the Term Expiration Date, subject to earlier termination of this Lease as provided herein.

4.              Tenant Improvements .

4.1            Prior to entering upon the Premises, Tenant shall furnish to Landlord evidence satisfactory to Landlord that insurance coverages required of Tenant under the provisions of Section 20 are in effect, and such entry shall be subject to all the terms and conditions of this Lease other than the payment of Basic Annual Rent or Additional Rent (as defined below).

4.2            Tenant hereby acknowledges that Tenant knows the condition of the Premises and agrees to accept the same in “as is” condition.  It is understood and agreed that Landlord is not obligated to install any equipment, or make any repairs, improvements or alterations to the Premises.  Tenant shall have the right to make appropriate repairs and improvements to the Premises in accordance with the terms and conditions of Section 17 hereof (“ Tenant Improvements ”). Tenant shall be responsible for performing and completing the Tenant Improvements.  Upon the Term Commencement Date, Landlord shall pay to Tenant a tenant improvement allowance (“ Tenant Improvement Allowance ”) in the amount of $1,700,000.00 to cover the reasonable cost of constructing Tenant’s Tenant Improvements to the Premises and related fees and expenses, including, but not limited to, labor, materials, space planning, construction documents, permits, fees, construction management, etc, as such costs may be demonstrated by Tenant to the reasonable satisfaction of Landlord.  All improvements shall be subject to the requirements of the Lease with respect to alternations and to building standards for finishes and materials.  Any direct or indirect Tenant Improvement costs that exceed the Tenant Improvement Allowance shall be paid by Tenant.  Tenant shall pay to Landlord as Additional Rent the Tenant Improvement Allowance, together with interest thereon at the rate of ten and one-half percent (10.5%) per annum, which amount shall be amortized over the original Term of the Lease and shall be due and payable in equal monthly installments of Twenty-Two Thousand Seven Hundred Thirty-Nine and 97/100 Dollars ($22,739.97) per month when Basic Monthly Rent is due and payable under the Lease

4.3            Landlord and Tenant shall mutually agree upon the selection of the architect, engineer, general contractor and major subcontractors, and Landlord and Tenant shall each participate in the review of the competitive bid process.

5.              Rent .

5.1.           Tenant shall pay to Landlord as Basic Annual Rent for the Premises, commencing on the Term Commencement Date, the sum set forth in Section 2.4 , subject to the rental adjustments provided in Section 6 hereof. Basic Annual Rent shall be paid in equal monthly installments as set forth in Section 2.3 (“ Basic Monthly Rent ”), subject to the rental adjustments provided in Section 6 hereof, each in advance on the first day of each and every calendar month during the Term.

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5.2.           In addition to Basic Annual Rent, Tenant shall pay to Landlord as additional rent (“ Additional Rent ”) at times hereinafter specified in this Lease (a) amounts related to Insurance Costs and Taxes (each as defined below) and (b) any other amounts that Tenant assumes or agrees to pay under the provisions of this Lease that are owed to Landlord, including, without limitation, any and all other sums that may become due by reason of any default of Tenant or failure on Tenant’s part to comply with the agreements, terms, covenants and conditions of this Lease to be performed by Tenant, after notice and the lapse of any applicable cure periods.

5.3.           Basic Annual Rent and Additional Rent shall together be denominated “ Rent .” Rent shall be paid to Landlord, without abatement, deduction or offset, in lawful money of the United States of America at the office of Landlord as set forth in Section 2.9 or to such other person in the United States or at such other place as Landlord may from time designate in writing. In the event the Term commences or ends on a day other than the first day of a calendar month, then the Rent for such fraction of a month shall be prorated for such period on the basis of a thirty (30) day month and shall be paid at the then-current rate for such fractional month.

6.              Rent Adjustments . The Basic Annual Rent shall be subject to an annual upward adjustment of two percent (2%) of the then-current Basic Annual Rent.  The first such adjustment shall become effective commencing July 1, 2007, and subsequent adjustments shall become effective on every successive July 1 for so long as this Lease continues in effect.

7.              Taxes .

7.1.           Commencing with the Term Commencement Date and continuing for each calendar year or, at Landlord’s option, tax year (each such “tax year” being a period of twelve (12) consecutive calendar months for which the applicable taxing authority levies or assesses Taxes), for the balance of the Term, Tenant shall pay to Landlord the amount of all Taxes levied and assessed for any such year upon the Premises during the Term.  “ Taxes ” shall mean all government impositions including, without limitation, property tax costs consisting of real and personal property taxes and assessments (including amounts due under any improvement bond upon the Premises or any portion thereof, including the parcel or parcels of real property upon which the Building is located or assessments levied in lieu thereof) imposed by any federal, state, regional, local or municipal governmental authority, agency or subdivision (each, a “ Governmental Authority ”) on the Premises or improvements thereon, any tax on or measured by gross rentals received from the rental of space in the Building, or tax based on the square footage of the Premises or the Building as well as any parking charges, utilities surcharges, or any other costs levied, assessed or imposed by, or at the direction of, or resulting from statutes or regulations, or interpretations thereof, promulgated by any Governmental Authority in connection with the use or occupancy of the Premises or the parking facilities serving the Premises; any tax on this transaction or this Lease; provided , however, that “ Taxes ” shall in no event include any franchise or income tax or any tax based on net rentals received from the rental of space in the Building. Any amount paid by Tenant for any partial year of the Term shall be prorated on the basis of the number of days of such partial year.  Payment shall be made in the following manner:  Tenant shall pay to Landlord the amounts owed under this Section 7 within thirty (30) days after Landlord gives notice to Tenant of the amount of such Taxes payable by Tenant (or not less than twenty (20) days prior to delinquency, whichever is later). Landlord also shall provide Tenant with a copy of the applicable tax bill or tax statement from the relevant taxing authority.  Notwithstanding the foregoing, if Applicable Laws allow any such Taxes to be paid in installments, then Tenant may make such payments to Landlord in installments, provided that each such installment shall be payable to Landlord not less than twenty (20) days prior to the date upon which payment of the applicable installment to the taxing authority becomes delinquent.  In addition to any other amounts due from Tenant to Landlord, if Tenant fails to pay Taxes to Landlord as herein required, Tenant shall pay to Landlord the amount of any interest, penalties or late charges imposed for late payment.  “ Applicable Laws ” means all laws, codes, ordinances, rules and regulations of Governmental Authorities having jurisdiction over the Premises or any portion thereof, or over Landlord or Tenant.

(a)            If the Premises are separately assessed, Tenant shall have the right, by appropriate proceedings, to protest or contest in good faith any assessment or reassessment of Taxes, any special assessment, or the validity of any Taxes or of any change in assessment or tax rate; provided , however, that prior to any such challenge Tenant must either (a) pay the Taxes alleged to be due in their entirety and seek a refund from the appropriate authority or (b) post a

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bond in an amount sufficient to ensure full payment of the Taxes, including any potential interest, late charges and penalties. Upon a final determination with respect to any such contest or protest, Tenant shall promptly pay to the appropriate Governmental Authority all sums found to be due with respect thereto. In any such protest or contest, Tenant may act in its own name, and at the request of Tenant, Landlord shall cooperate with Tenant in any way Tenant may reasonably require in connection with such contest or protest, including signing such documents as Tenant reasonably shall request, provided that such cooperation shall be at no expense to Landlord and shall not require Landlord to attend any appeal or other hearing.  Any such contest or protest shall be at Tenant’s sole expense, and if any penalties, interest or late charges become payable with respect to the Taxes as a result of such contest or protest, Tenant shall pay the same.

(b)           If Tenant obtains a refund as the result of Tenant’s protest or contest, and subject to Tenant’s obligation to pay Landlord’s costs (if any) associated therewith, Tenant shall be entitled to such refund to the extent it relates to the Premises during the Term.

7.2.           Tenant shall be solely responsible for the payment of any and all taxes levied upon personal property and trade fixtures located upon the Premises, and shall pay the same at least ten (10) days prior to delinquency.

7.3.           If, at any time during the Term under the laws of any Governmental Authority, a tax or excise on rent or any other tax howsoever described is levied or assessed by any such political body against Landlord on account of rentals payable to Landlord hereunder, such tax or excise shall be considered “ Taxes ” for the purposes of this Section 7 , although any amount assessed against Landlord as state or federal income tax shall not be deemed “ Taxes .”

7.4.           To the extent Landlord is required by a lender, Tenant shall timely pay all tax and insurance impound payments due on the Premises.

8.              Rentable Area .

8.1.           The term “ Rentable Area ” as set forth in Section 2 , and as may otherwise be referenced within this Lease.

8.2.           The “ Rentable Area ” of the Building is generally determined by making separate calculations of Rentable Area applicable to each floor within the Building and totaling the Rentable Area of all floors within the Building. The Rentable Area of a floor is computed by measuring to the outside finished surface of the permanent outer Building walls.  The full area calculated as previously set forth is included as Rentable Area, without deduction for columns and projections or vertical penetrations, including stairs, elevator shafts, flues, pipe shafts, vertical ducts and the like, as well as such items’ enclosing walls.

9.              Security Deposit .

9.1.           Tenant has deposited with Landlord the sum set forth in Section 2.7 (payable in cash or, in the form of a letter of credit reasonably acceptable to Landlord) (the “ Security Deposit ”), which Security Deposit shall be held by Landlord as security for the faithful performance by Tenant of all of the terms, covenants and conditions of this Lease to be kept and performed by Tenant during the period commencing on the Commencement Date and ending upon the expiration or termination of this Lease.  If Tenant defaults with respect to any provision of this Lease, including, but not limited to, any provision relating to the payment of Rent, then Landlord may (but shall not be required to) use, apply or retain all or any part of the Security Deposit for the payment of any Rent or any other sum in default, or to compensate Landlord for any other loss or damage that Landlord may suffer by reason of Tenant’s default.  If any portion of the Security Deposit is so used or applied, then Tenant shall, within ten (10) days following demand therefor, deposit cash with Landlord in an amount sufficient to restore the Security Deposit to its original amount, or replenish the letter of credit to the amount required hereunder, and Tenant’s failure to do so shall be a material breach of this Lease.  Landlord shall not be required to keep this Security Deposit separate from its general fund, and Tenant shall not be entitled to interest on the Security Deposit.

9.2.           In lieu of depositing cash as the Security Deposit, Tenant shall have the right to deliver to Landlord an unconditional, irrevocable, standby letter of credit in the amount of the cash Security Deposit otherwise required hereunder, which letter of credit shall (i) be in a form

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reasonably acceptable to Landlord, (ii) be issued by a financial institution selected by Tenant and reasonably acceptable to Landlord, (iii) be for the benefit of Landlord, but shall be transferable at Tenant’s sole cost and expense by Landlord to any subsequent purchaser or encumbrancer of the Building, and (iv) be payable by draft sight in a location reasonably acceptable to Landlord upon presentation of a certification signed by an officer of Landlord which states that an event of Default has occurred under this Lease, and (v) be payable in the event such letter of credit is not renewed on or before the date which is thirty (30) days prior to its expiration.  Any amounts of cash drawn on a letter of credit Security Deposit will thereafter be treated as a cash Security Deposit hereunder; provided that Tenant shall be permitted to restore the original balance of the letter of credit and have the corresponding cash Security Deposit returned to Tenant.

9.3.           In the event of bankruptcy or other debtor-creditor proceedings against Tenant, the Security Deposit shall be deemed to be applied first to the payment of Rent and other charges due Landlord for all periods prior to the filing of such proceedings.

9.4.           Landlord may deliver to any purchaser of Landlord’s interest in the Premises the funds deposited hereunder by Tenant, and thereupon Landlord shall be discharged from any further liability with respect to such deposit.  This provision shall also apply to any subsequent transfers.

9.5.           If Tenant shall fully and faithfully perform every provision of this Lease to be performed by it, then the Security Deposit, or any balance thereof, shall be returned to Tenant (or, at Landlord’s option, to the last assignee of Tenant’s interest hereunder) within thirty (30) days after the expiration or earlier termination of this Lease.

10.            Use .

10.1.         Tenant shall use the Premises for the purpose set forth in Section 2.8 , and shall not use the Premises, or permit or suffer the Premises to be used, for any other purpose without Landlord’s prior written consent, which consent Landlord may withhold in its sole and absolute discretion.

10.2.         Tenant shall not use or occupy the Premises in violation of Applicable Laws; zoning ordinances; or the certificate of occupancy issued for the Building, and shall, upon five (5) days’ written notice from Landlord, discontinue any use of the Premises that is declared or claimed by any Governmental Authority having jurisdiction to be a violation of any of the above, or that in Landlord’s reasonable opinion violates any of the above.  Tenant shall comply with any direction of any Governmental Authority having jurisdiction that shall, by reason of the nature of Tenant’s use or occupancy of the Premises, impose any duty upon Tenant or Landlord with respect to the Premises or with respect to the use or occupation thereof.

10.3.         Tenant shall not knowingly do or permit to be done anything that will invalidate or increase the cost of any fire, environmental, extended coverage or any other insurance policy covering the Premises, and shall comply with all rules, orders, regulations and requirements of the insurers of the Premises, and Tenant shall promptly, upon demand, reimburse Landlord for any additional premium charged for such policy by reason of Tenant’s failure to comply with the provisions of this Section.

10.4.         No awnings or other projections shall be attached to any outside wall of the Building.

10.5.         No additional sign, advertisement or notice shall be exhibited, painted or affixed by Tenant on any part of the exterior of the Building or on the Property without Landlord’s prior written consent, which will not be unreasonably withheld.  By executing this Lease, Landlord hereby approves the signage currently existing on the Premises.

10.6.         Tenant shall not use or allow the Premises to be used for unlawful purposes, nor shall Tenant knowingly cause, maintain or permit any nuisance or waste in, on or about the Premises.

10.7.         Notwithstanding any other provision herein to the contrary, Tenant shall be responsible for all liabilities, costs and expenses arising out of or in connection with the compliance of the Premises with the Americans with Disabilities Act, 42 U.S.C. § 12101, et seq.

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(together with regulations promulgated pursuant thereto, the “ ADA ”), and Tenant shall indemnify, defend and hold harmless Landlord from and against any loss, cost, liability or expense (including reasonable attorneys’ fees and disbursements) arising out of any failure of the Premises to comply with the ADA.  The provisions of this Section 10.7 shall survive the expiration or earlier termination of this Lease.

11.            Brokers .

11.1.         Tenant represents and warrants that it has had no dealings with any real estate broker or agent in connection with the negotiation of this Lease and that it knows of no real estate broker or agent that is or might be entitled to a commission in connection with this Lease.

11.2.         Tenant represents and warrants that no broker or agent has made any representation or warranty relied upon by Tenant in Tenant’s decision to enter into this Lease, other than as contained in this Lease.

11.3.         Tenant acknowledges and agrees that the employment of brokers by Landlord is for the purpose of solicitation of offers of leases from prospective tenants and that no authority is granted to any broker to furnish any representation (written or oral) or warranty from Landlord unless expressly contained within this Lease.  Landlord is executing this Lease in reliance upon Tenant’s representations and warranties contained within Sections 11.1 and 11.2 .

12.            Holding Over .

12.1.         If, with Landlord’s prior written consent, Tenant holds possession of all or any part of the Premises after the Term, Tenant shall become a tenant from month to month after the expiration or earlier termination of the Term, and in such case Tenant shall continue to pay (a) the Basic Annual Rent in accordance with Section 5 , as adjusted in accordance with Section 6 , and (b) any amounts for which Tenant would otherwise be liable under this Lease if the Lease were still in effect, including, without limitation, payments for Taxes and insurance. Any such month-to-month tenancy shall be subject to every other term, covenant and agreement contained herein.

12.2.         Notwithstanding the foregoing, if Tenant remains in possession of the Premises after the expiration or earlier termination of the Term without Landlord’s prior written consent, Tenant shall become a tenant at sufferance subject to the terms and conditions of this Lease, except that the Basic Monthly Rent shall be equal to one hundred fifty percent (150%) of the Rent in effect during the last thirty (30) days of the Term.

12.3.         Acceptance by Landlord of Rent after the expiration or earlier termination of the Term shall not result in an extension, renewal or reinstatement of this Lease.

12.4.         The foregoing provisions of this Section 12 are in addition to and do not affect Landlord’s right of reentry or any other rights of Landlord hereunder or as otherwise provided by Applicable Laws.

13.            Property Management Fee . Tenant shall pay to Landlord on the first day of each calendar month of the Term, as Additional Rent, the “ Property Management Fee ,” which shall equal $2,645.00 per month.

14.            Condition of Premises . Tenant acknowledges that neither Landlord nor any agent of Landlord has made any representation or warranty with respect to the condition of the Premises, or with respect to the suitability of the Premises for the conduct of Tenant’s business.  Tenant’s taking of possession of the Premises shall, except as otherwise agreed to in writing by Landlord and Tenant, conclusively establish that Tenant accepts the Premises “as is.”

15.            Utilities and Services .

15.1.         Tenant shall, at its sole cost and expense, promptly and properly observe and comply with (including in the making by Tenant of any alterations to the Premises) all present and future orders, regulations, directions, rules, laws, ordinances, and requirements of all Governmental Authorities arising from the use or occupancy of, or applicable to, the Premises or any portion thereof.

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15.2.         Within sixty (60) days after the Term Commencement Date, and within sixty (60) days after the beginning of each calendar year during the Term, Landlord shall give Tenant a written estimate for such calendar year of insurance provided by Landlord (“ Insurance Costs ”). Tenant shall pay such estimated amount to Landlord in advance in equal monthly installments. Within ninety (90) days after the end of each calendar year, Landlord shall furnish to Tenant a statement showing in reasonable detail the costs incurred by Landlord for the operation and maintenance of the Premises during such year (the “ Annual Statement ”), and Tenant shall pay to Landlord the costs incurred in excess of the payments previously made by Tenant within ten (10) days of receipt of the Annual Statement.  In the event that the payments previously made by Tenant for the operation and maintenance of the Premises exceed Tenant’s obligation, such excess amount shall be credited by Landlord to the Rent or other charges next due and owing, provided that, if the Term has expired, Landlord shall remit such excess amount to Tenant.

15.3.         Tenant shall make all arrangements for and pay for all water, sewer, gas, heat, light, power, telephone service and any other service or utility Tenant required at the Premises. Landlord shall not be liable for, nor shall any eviction of Tenant result from, the failure to furnish any utility or service, whether or not such failure is caused by accident; breakage; repair; strike, lockout or other labor disturbance or labor dispute of any character; governmental regulation, moratorium or other governmental action (collectively, “ Force Majeure ”). In the event of such failure, Tenant shall not be entitled to termination of this Lease, any abatement or reduction of Rent, or relief from the operation of any covenant or agreement of this Lease.  Tenant shall pay for, prior to delinquency of payment therefor, any utilities and services that may be furnished to the Premises during or, if Tenant occupies the Premises after the expiration or earlier termination of the Term, after the Term.

16.            Alterations .

16.1.         Tenant shall make no alterations, additions or improvements in or to the Premises that cost in excess of $100,000 without Landlord’s prior written approval, which approval Landlord shall not unreasonably withhold; provided , however , that in the event any proposed alteration, addition or improvement affects (a) any structural portions of the Building, including exterior walls, roof, foundation or core of the Building, (b) the exterior of the Building or (c) any Building systems, including elevator, plumbing, air conditioning, heating, electrical, security, life safety and power, then Landlord may withhold its approval with respect thereto in its sole and absolute discretion. In seeking Landlord’s approval, Tenant shall provide Landlord, at least fourteen (14) days in advance of any proposed construction, with plans, specifications, bid proposals, work contracts, requests for laydown areas and such other information concerning the nature and cost of the alterations as Landlord may reasonably request.

16.2.         Tenant shall not construct or permit to be constructed partitions or other obstructions that might interfere with free access to mechanical installation or service facilities of the Building, or interfere with the moving of Landlord’s equipment to or from the enclosures containing such installations or facilities.

16.3.         Tenant shall accomplish any work performed on the Premises in such a manner as to permit any fire sprinkler system and fire water supply lines to remain fully operable at all times.

16.4.         Tenant covenants and agrees that all work done by Tenant or Tenant’s contractors shall be performed in full compliance with Applicable Laws.  Tenant shall provide Landlord with complete “as-built” drawing print sets and electronic CADD files on disc showing any changes in the Premises for which Landlord’s approval is required pursuant to Section 16.1 .

16.5.         Before commencing any work for which Landlord’s approval is required pursuant to Section 16.1 , Tenant shall give Landlord at least fourteen (14) days’ prior written notice of the proposed commencement of such work and shall, if required by Landlord, secure, at Tenant’s own cost and expense, a completion and lien indemnity bond satisfactory to Landlord for said work.

16.6.         All alterations, attached equipment, fixtures, additions and improvements, subject to Section 17.6 , attached to or built into the Premises, made by either of the Parties, including, without limitation, all flooring and wall coverings, built-in cabinet work and paneling, sinks and related plumbing fixtures, exterior venting fume hoods and walk-in freezers and refrigerators, ductwork, conduits, electrical panels and circuits, shall, unless, prior to such construction or installation, Landlord elects otherwise, become the property of Landlord upon the expiration or

7




earlier termination of the Term, and shall remain upon and be surrendered with the Premises as a part thereof.

 

16.7.         Tenant shall repair any damage to the Premises caused by Tenant’s removal of any property from the Premises.  During any such restoration period, Tenant shall pay Rent to Landlord as provided herein as if said space were otherwise occupied by Tenant.

16.8.         Except as to those items listed on Exhibit C attached hereto, all fixtures (except for Tenant’s trade fixtures), built-in furniture and cabinets installed in and upon the Premises shall be and remain the property of Landlord and shall not be moved by Tenant at any time during the Term. If Tenant shall fail to remove any of its effects from the Premises prior to termination of this Lease, then Landlord may, at its option, remove the same in any manner that Landlord shall choose and store said effects without liability to Tenant for loss thereof or damage thereto, and Tenant shall pay Landlord, upon demand, any costs and expenses incurred due to such removal and storage or Landlord may, at its sole option and without notice to Tenant, sell such property or any portion thereof at private sale and without legal process for such price as Landlord may obtain and apply the proceeds of such sale against any (a) amounts due by Tenant to Landlord under this Lease and (b) any expenses incident to the removal, storage and sale of said personal property.

16.9.         Notwithstanding any other provision of this Section 16 to the contrary, in no event shall Tenant remove any improvement from the Premises as to which Landlord contributed payment without Landlord’s prior written consent, which consent Landlord may withhold in its sole and absolute discretion.

16.10.       Tenant shall reimburse Landlord for any extra expenses incurred by Landlord by reason of faulty work done by Tenant or its contractors, or by reason of delays caused by such work, or by reason of inadequate clean-up.

16.11.       After final completion of the Tenant Improvements (or any other alterations, improvement or additions performed by Tenant with respect to the Premises) for which Landlord approval is required pursuant to Section 16.1 , Tenant shall submit to Landlord documentation showing the amounts expended by Tenant with respect to such Tenant Improvements (or any other alterations, improvement or additions performed by Tenant with respect to the Premises).

17.            Repairs and Maintenance .

17.1.         Tenant, at its sole cost and expense, shall maintain and keep the Premises, all improvements thereon, and all appurtenances thereto, including but not limited to sidewalks, parking areas, curbs, roads, driveways, lighting standards, landscaping, sewers, water, gas and electrical distribution systems and facilities, drainage facilities, and all signs, both illuminated and non-illuminated that are now or hereafter on the Premises, in good condition and in a manner consistent with the Permitted Use. Tenant shall make all repairs, replacements and improvements, including, without limitation, all structural, roof, HVAC, plumbing and electrical repairs, replacements and improvements required, and shall keep the same free and clear from all rubbish and debris. All repairs made by Tenant shall be at least equal in quality to the original work, and shall be made only by a licensed bondable contractor.  Tenant shall not take or omit to take any action, the taking or omission of which shall cause waste, damage or injury to the Premises. Tenant shall indemnify, defend (by legal counsel acceptable to Landlord) and hold harmless Landlord from and against any and all Claims (as defined below) arising out of the failure of Tenant or Tenant’s Agents to perform the covenants contained in this paragraph.  “ Tenant’s Agents ” shall be defined to include Tenant’s officers, employees, agents, contractors, invitees, customers and subcontractors.

17.2.         Tenant shall maintain the lines designating the parking spaces in good condition and paint the same as often as may be necessary, so that they are easily discernable at all times; resurface the parking areas as necessary to maintain them in good condition; paint any exterior portions of the Building as necessary to maintain them in good condition; maintain the roof and landscaping in good condition; maintain sightly screens, barricades or enclosures around any waste or storage areas; and take all reasonable precautions to insure that the drainage facilities of the roof are not clogged and are in good and operable condition at all times.

17.3.         There shall be no abatement of Rent and no liability of Landlord by reason of any injury to or interference with Tenant’s business arising from the making of any repairs, alterations

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or improvements in or to any portion of the Premises, or in or to improvements, fixtures, equipment and personal property therein; provided that Landlord shall not unreasonably interfere with Tenant’s use or quiet enjoyment of the Premises.

 

17.4.         Except as provided in Section 21 (Damage or Destruction), during the Term, Landlord shall not be required to maintain or make any repairs or replacements of any nature or description whatsoever to the Premises.  Tenant hereby expressly waives the right to make repairs at the expense of Landlord as provided for in any Applicable Laws in effect at the time of execution of this Lease, or in any other Applicable Laws that may hereafter be enacted, and waives its rights under Applicable Laws relating to a landlord’s duty to maintain its premises in a tenantable condition. Notwithstanding the foregoing, if Tenant shall fail, after reasonable notice, to maintain or to commence and thereafter to proceed with diligence to make any repair required of it pursuant to the terms of this Lease, Landlord, without being under any obligation to do so and without thereby waiving such default by Tenant, may so maintain or make such repair and may charge Tenant for the costs thereof. Any expense reasonably incurred by Landlord in connection with the making of such repairs may be billed by Landlord to Tenant monthly or, at Landlord’s option, immediately, and shall be due and payable within ten (10) days after such billing or, at Landlord’s option, may be deducted from the Security Deposit.

17.5.         Landlord and Landlord’s agents shall have the right to enter upon the Premises or any portion thereof for the purposes of performing any repairs or maintenance Landlord is permitted to make pursuant to this Lease, and of ascertaining the condition of the Premises or whether Tenant is observing and performing Tenant’s obligations hereunder, all without unreasonable interference from Tenant or Tenant’s Agents.  Except for emergency maintenance or repairs, the right of entry contained in this paragraph shall be exercisable at reasonable times, at reasonable hours and on reasonable notice.

17.6.         Tenant shall, upon the expiration or sooner termination of the Term, surrender the Premises to Landlord in as good of a condition as when received, ordinary wear and tear excepted. The parties acknowledge the nonfunctional status of certain equipment listed on Exhibit F attached hereto (the “ Nonfunctional Equipment ”). Landlord shall have no obligation to alter, remodel, improve, repair, decorate or paint the Premises or any part thereof.

17.7.         This Section 17 relates to repairs and maintenance arising in the ordinary course of operation of the Premises and any related facilities.  In the event of fire, earthquake, flood, vandalism, war or similar cause of damage or destruction, Section 21 shall apply in lieu of this Section 17 .

18.            Liens .

18.1.         Subject to the immediately succeeding sentence, Tenant shall keep the Premises free from any liens arising out of work performed, materials furnished or obligations incurred by Tenant. Tenant further covenants and agrees that any mechanic’s lien filed against the Premises for work claimed to have been done for Tenant, or materials claimed to have been furnished to Tenant, shall be discharged or bonded by Tenant within ten (10) days after Tenant is given notice thereof, at Tenant’s sole cost and expense.

18.2.         Should Tenant fail to discharge or bond against any lien of the nature described in Section 18.1 , Landlord may, at Landlord’s election, pay such claim or post a bond or otherwise provide security to eliminate the lien as a claim against title, and Tenant shall immediately reimburse Landlord for the costs thereof as Additional Rent.

18.3.         In the event that Tenant leases or finances the acquisition of office equipment, furnishings or other personal property of a removable nature utilized by Tenant in the operation of Tenant’s business, Tenant warrants that any Uniform Commercial Code financing statement executed by Tenant shall, upon its face or by exhibit thereto, indicate that such financing statement is applicable only to removable personal property of Tenant located within the Premises.  In no event shall the address of the Premises be furnished on a financing statement without qualifying language as to applicability of the lien only to removable personal property located in an identified suite leased by Tenant. Should any holder of a financing statement executed by Tenant record or place of record a financing statement that appears to constitute a lien against any interest of Landlord or against equipment that may be located other than within an identified suite leased by Tenant, Tenant shall, within ten (10) days after filing such financing statement, cause (a) a copy of

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the lender security agreement or other documents to which the financing statement pertains to be furnished to Landlord to facilitate Landlord’s ability to demonstrate that the lien of such financing statement is not applicable to Landlord’s interest and (b) Tenant’s lender to amend such financing statement and any other documents of record to clarify that any liens imposed thereby are not applicable to any interest of Landlord in the Premises.

19.            Indemnification and Exculpation .

19.1.         Tenant agrees to indemnify, defend and save Landlord harmless from and against any and all demands, claims, liabilities, losses, costs, expenses, actions, causes of action, damages or judgments, and all reasonable expenses (including, without limitation, reasonable attorneys’ fees, charges and disbursements) incurred in investigating or resisting the same (collectively, “ Claims ”) arising from injury or death to any person or injury to any property occurring within or about the Premises arising directly or indirectly out of Tenant’s or Tenant’s employees’, agents’ or guests’ use or occupancy of the Premises or a breach or default by Tenant in the performance of any of its obligations hereunder, except to the extent caused by Landlord’s willful misconduct or gross negligence.

19.2.         Notwithstanding any provision of Section 19.1 to the contrary, Landlord shall not be liable to Tenant for, and Tenant assumes all risk of, damage to personal property or scientific research, including, without limitation, loss of records kept by Tenant within the Premises and damage or losses caused by fire, electrical malfunction, gas explosion or water damage of any type (including, without limitation, broken water lines, malfunctioning fire sprinkler systems, roof leaks or stoppages of lines), unless any such loss is due to Landlord’s willful disregard of written notice by Tenant of need for a repair that Landlord is responsible to make for an unreasonable period of time, or Landlord’s willful misconduct or gross negligence.  Tenant further waives any claim for injury to Tenant’s business or loss of income relating to any such damage or destruction of personal property as described in this  Section 19.2.

19.3.         Landlord shall not be liable for any damages arising from any act, omission or neglect of any third party in connection with the Premises.

19.4.         Tenant acknowledges that security devices and services, if any, while intended to deter crime, may not in given instances prevent theft or other criminal acts. Landlord shall not be liable for injuries or losses caused by criminal acts of third parties, and Tenant assumes the risk that any security device or service may malfunction or otherwise be circumvented by a criminal.  If Tenant desires protection against such criminal acts, then Tenant shall, at Tenant’s sole cost and expense, obtain appropriate insurance coverage.

19.5.         The provisions of this Section 19 shall survive the expiration or earlier termination of this Lease.

20.            Insurance; Waiver of Subrogation .

20.1.         Landlord shall maintain insurance for the Property and the Building in amounts equal to full replacement cost (exclusive of the costs of excavation, foundations and footings, and without reference to depreciation taken by Landlord upon its books or tax returns).  Landlord, subject to availability thereof, shall further insure, if Landlord deems it appropriate, coverage against flood, environmental hazard, earthquake, loss or failure of building equipment, rental loss during the period of repairs or rebuilding, workmen’s compensation insurance and fidelity bonds for employees employed to perform services.  Notwithstanding the foregoing, Landlord may, but shall not be deemed required to, provide insurance for any improvements installed by Tenant or that are in addition to the standard improvements customarily furnished by Landlord, but only to the extent such are made a part of or are affixed to the Building.

20.2.         In addition, Landlord shall carry public liability insurance with a single limit of not less than One Million Dollars ($1,000,000) for death or bodily injury, or property damage with respect to the Property.

20.3.         Tenant shall, at its own cost and expense, procure and maintain in effect, beginning on the Term Commencement Date or the date of occupancy, whichever occurs first, and continuing throughout the Term (and occupancy by Tenant, if any, after termination of this Lease) comprehensive public liability insurance with limits of not less than Two Million Dollars

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($2,000,000) per occurrence for death or bodily injury and not less than One Million Dollars ($1,000,000) for property damage with respect to the Premises.

 

20.4.         The insurance required to be purchased and maintained by Tenant pursuant to this Lease shall name Landlord, BioMed Realty, L.P., BioMed Realty Trust, Inc., and their respective officers, employees, agents, general partners, members and Lenders (“ Landlord Parties ”) as additional insureds. Said insurance shall be with companies having a rating of not less than policyholder rating of A and financial category rating of at least Class XII in “Best’s Insurance Guide.” Tenant shall obtain for Landlord from the insurance companies or cause the insurance companies to furnish certificates of coverage to Landlord.  No such policy shall be cancelable or subject to reduction of coverage or other modification or cancellation except after thirty (30) days’ prior written notice to Landlord from the insurer.  All such policies shall be written as primary policies, not contributing with and not in excess of the coverage that Landlord may carry.  Tenant’s policy may be a “blanket policy” that specifically provides that the amount of insurance shall not be prejudiced by other losses covered by the policy.  Tenant shall, at least twenty (20) days prior to the expiration of such policies, furnish Landlord with renewals or binders.  Tenant agrees that if Tenant does not take out and maintain such insurance, Landlord may (but shall not be required to) procure said insurance on Tenant’s behalf and at its cost to be paid by Tenant as Additional Rent.

20.5.         Tenant assumes the risk of damage to any fixtures, goods, inventory, merchandise, equipment and leasehold improvements, and Landlord shall not be liable for injury to Tenant’s business or any loss of income therefrom, relative to such damage, except to the extent caused by Landlord’s gross negligence or intentional misconduct.  Tenant shall, at Tenant’s sole cost and expense, carry such insurance as Tenant desires for Tenant’s protection with respect to personal property of Tenant or business interruption.

20.6.         In each instance where insurance is to name Landlord Parties as additional insureds, Tenant shall, upon Landlord’s written request, also designate and furnish certificates evidencing such Landlord Parties as additional insureds to (a) any Lender of Landlord holding a security interest in the Premises or any portion thereof, (b) the landlord under any lease whereunder Landlord is a tenant of the real property upon which the Building is located if the interest of Landlord is or shall become that of a tenant under a ground lease rather than that of a fee owner, and (c) any management company retained by Landlord to manage the Premises.

20.7.         Landlord and Tenant each hereby waive any and all rights of recovery against the other or against the officers, directors, employees, agents and representatives of the other on account of loss or damage occasioned by such waiving party or its property or the property of others under such waiving party’s control, in each case to the extent that such loss or damage is insured against under any fire and extended coverage insurance policy that either Landlord or Tenant may have in force at the time of such loss or damage.  Such waivers shall continue so long as their respective insurers so permit.  Any termination of such a waiver shall be by written notice to the other party, containing a description of the circumstances hereinafter set forth in this Section 20.7 . Landlord and Tenant, upon obtaining the policies of insurance required or permitted under this Lease, shall give notice to the insurance carrier or carriers that the foregoing mutual waiver of subrogation is contained in this Lease.  If such policies shall not be obtainable with such waiver or shall be so obtainable only at a premium over that chargeable without such waiver, then the party seeking such policy shall notify the other of such conditions, and the party so notified shall have ten (10) days thereafter to either (a) procure such insurance with companies reasonably satisfactory to the other party or (b) agree to pay such additional premium.  If the parties do not accomplish either (a) or (b), then this Section 20.7 shall have no effect during such time as such policies shall not be obtainable or the party in whose favor a waiver of subrogation is desired refuses to pay the additional premium.  If such policies shall at any time be unobtainable, but shall be subsequently obtainable, then neither party shall be subsequently liable for a failure to obtain such insurance until a reasonable time after notification thereof by the other party.  If the release of either Landlord or Tenant, as set forth in the first sentence of this Section 20.7 , shall contravene Applicable Laws, then the liability of the party in question shall be deemed not released but shall be secondary to the other party’s insurer.

20.8.         Any costs incurred by Landlord pursuant to this Section 20 shall be included as Insurance Costs payable by Tenant pursuant to this Lease.

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21.            Damage or Destruction .

21.1.         In the event of a partial destruction of the Premises by fire or other perils covered by extended coverage insurance not exceeding 50% of the full insurable value thereof, and provided that the damage thereto is such that the Premises may be repaired, reconstructed or restored within a period of 12 months from the date of the happening of such casualty.  Landlord shall commence and proceed diligently with the work of repair, reconstruction and restoration of the Premises, and this Lease shall continue in full force and effect.

21.2.         In the event of any damage to or destruction of the Premises other than as described in Section 21.1 , Landlord may elect to repair, reconstruct and restore the Premises, in which case this Lease shall continue in full force and effect.  If Landlord elects not to repair the Premises, then this Lease shall terminate as of the date of such damage or destruction.

21.3.         Landlord shall give written notice to Tenant of its election not to repair, reconstruct or restore the Premises within sixty (60) days following the date of damage or destruction.

21.4.         Upon any termination of this Lease under any of the provisions of this Section 21 , the parties shall be released thereby without further obligation to the other from the date possession of the Premises is surrendered to the Landlord, except with regard to (a) items occurring prior to the damage or destruction and (b) provisions of this Lease that, by their express terms, survive the expiration or earlier termination hereof.

21.5.         In the event of repair, reconstruction and restoration as provided in this Section 21 , all Rent to be paid by Tenant under this Lease shall be abated proportionately based on the extent to which Tenant’s use of the Premises is impaired during the period of such repair, reconstruction or restoration, unless Landlord provides Tenant with other space during the period of repair that, in Tenant’s reasonable opinion, is suitable for the temporary conduct of Tenant’s business.

21.6.         Notwithstanding anything to the contrary contained in this Section 21 , should Landlord be delayed or prevented from completing the repair, reconstruction or restoration of the damage or destruction to the Premises after the occurrence of such damage or destruction by Force Majeure, then the time for Landlord to commence or complete repairs shall be extended on a day-for-day basis; provided , however , that, if such Force Majeure event continues for more than 120 days, Tenant shall have the right to terminate this Lease.  Tenant shall be released from any obligations under this Lease (except with regard to those provisions that, by their express terms, survive the expiration or earlier termination hereof) if, on the date that is 12 months after the date of damage or destruction, the repair, reconstruction or restoration required to be performed by Landlord to provide Tenant use of the Premises is not then Substantially Completed.

21.7.         If Landlord is obligated to or elects to repair, reconstruct or restore as herein provided, then Landlord shall be obligated to make such repair, reconstruction or restoration only with regard to those portions of the Premises that were originally provided at Landlord’s expense. The repair, reconstruction or restoration of improvements not originally provided by Landlord or at Landlord’s expense shall be the obligation of Tenant.  In the event Tenant has elected to upgrade certain improvements from the Building Standard, Landlord shall, upon the need for replacement due to an insured loss, provide only the Building Standard, unless Tenant again elects to upgrade such improvements and pay any incremental costs related thereto, except to the extent that excess insurance proceeds, if received, are adequate to provide such upgrades, in addition to providing for basic repair, reconstruction and restoration of the Premises.

21.8.         Notwithstanding anything to the contrary contained in this Section 21 , Landlord shall not have any obligation whatsoever to repair, reconstruct or restore the Premises if the damage resulting from any casualty covered under this Section 21 occurs during the last eighteen (18) months of the Term or any extension hereof, or to the extent that insurance proceeds are not available therefore, unless such lack of availability is due to Landlord’s failure to maintain insurance in accordance with this Lease.

21.9.         Landlord’s obligation, should it elect or be obligated to repair or rebuild, shall be limited to the Premises; provided that Tenant shall, at its expense, replace or fully repair all of Tenant’s personal property.  If the Premises are to be repaired in accordance with the foregoing, Landlord shall make available to Tenant any portion of insurance proceeds it receives that are

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allocable to the alterations constructed by Tenant pursuant to this Lease, provided Tenant is not then in default under this Lease.

22.            Eminent Domain .

22.1.         In the event the whole of the Premises, or such part thereof as shall substantially interfere with the Tenant’s use and occupancy thereof, shall be taken for any public or quasi-public purpose by any lawful power or authority by exercise of the right of appropriation, condemnation or eminent domain, or sold to prevent such taking, Tenant or Landlord may terminate this Lease effective as of the date possession is required to be surrendered to said authority.

22.2.         In the event of a partial taking of the Premises, or of drives, walkways or parking areas serving the Premises for any public or quasi-public purpose by any lawful power or authority by exercise of right of appropriation, condemnation, or eminent domain, or sold to prevent such taking, then, without regard to whether any portion of the Premises occupied by Tenant was so taken, Landlord may elect to terminate this Lease as of such taking if such taking is, in Landlord’s reasonable opinion, of a material nature such as to make it uneconomical to continue use of the unappropriated portion for purposes of renting office or laboratory space.

22.3.         Tenant shall be entitled to any award that is specifically awarded as compensation for (a) the taking of Tenant’s personal property that was installed at Tenant’s expense and (b) the costs of Tenant moving to a new location.  Except as set forth in the previous sentence, any award for such taking shall be the property of Landlord.

22.4.         If, upon any taking of the nature described in this Section 22 , this Lease continues in effect, then Landlord shall promptly proceed to restore the Premises to substantially their same condition prior to such partial taking.  To the extent such restoration is feasible, as determined by Landlord in its reasonable discretion, the Rent shall be decreased by a number, the numerator of which is the rental value of the Premises prior to such taking, and the denominator of which is the value of the Premises after such taking.

23.            Defaults and Remedies .

23.1.         Late payment by Tenant to Landlord of Rent and other sums due shall cause Landlord to incur costs not contemplated by this Lease, the exact amount of which shall be extremely difficult and impracticable to ascertain.  Such costs include, but are not limited to, processing and accounting charges and late charges that may be imposed on Landlord by the terms of any mortgage or trust deed covering the Premises.  Therefore, if any installment of Rent due from Tenant is not received by Landlord within five (5) days after the date such payment is due, Tenant shall pay to Landlord an additional sum of five percent (5%) of the overdue Rent as a late charge. The parties agree that this late charge represents a fair and reasonable estimate of the costs that Landlord shall incur by reason of late payment by Tenant.  In addition to the late charge, Rent not paid when due shall bear interest from the fifth (5 th ) day after the date due until paid at the lesser of (a) twelve percent (12%) per annum or (b) the maximum rate permitted by Applicable Laws.

23.2.         No payment by Tenant or receipt by Landlord of a lesser amount than the Rent payment herein stipulated shall be deemed to be other than on account of the Rent, nor shall any endorsement or statement on any check or any letter accompanying any check or payment as Rent be deemed an accord and satisfaction, and Landlord may accept such check or payment without prejudice to Landlord’s right to recover the balance of such Rent or pursue any other remedy provided in this Lease or in equity or at law.  If a dispute shall arise as to any amount or sum of money to be paid by Tenant to Landlord hereunder, Tenant shall have the right to make payment “under protest,” such payment shall not be regarded as a voluntary payment, and there shall survive the right on the part of Tenant to institute suit for recovery of the payment paid under protest.

23.3.         If Tenant fails to pay any sum of money (other than Basic Annual Rent or Rental Adjustments) required to be paid by it hereunder, or shall fail to perform any other act on its part to be performed hereunder, Landlord may, without waiving or releasing Tenant from any obligations of Tenant, but shall not be obligated to, make such payment or perform such act; provided that such failure by Tenant continues for 5 days after Landlord delivers notice to Tenant demanding performance by Tenant; or that such failure by Tenant unreasonably interfered with the efficient

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operation of the Premises, or resulted or could have resulted in a violation of Applicable Laws or the cancellation of an insurance policy maintained by Landlord.  Tenant shall pay to Landlord as Additional Rent all sums so paid or incurred by Landlord, together with interest thereon, from the date such sums were paid or incurred, at the annual rate equal to twelve percent (12%) per annum or highest rate permitted by Applicable Laws, whichever is less.

23.4.         The occurrence of any one or more of the following events shall constitute a “ Default ” hereunder by Tenant:

(a)            The abandonment or vacation of the Premises by Tenant;

(b)            The failure by Tenant to make any payment of Rent, as and when due, where such failure shall continue for a period of 5 days after written notice thereof from Landlord to Tenant;

(c)            The failure by Tenant to observe or perform any obligation or covenant contained herein (other than described in Subsections 23.4(a) and 23.4(b)) to be performed by Tenant, where such failure shall continue for a period of 30 days after written notice thereof from Landlord to Tenant; provided that, if the nature of Tenant’s default is such that it reasonably requires more than 30 days to cure, Tenant shall not be deemed to be in default if Tenant shall commence such cure within said 30-day period and thereafter diligently prosecute the same to completion;

(d)            Tenant makes an assignment for the benefit of creditors;

(e)            A receiver, trustee or custodian is appointed to or does take title, possession or control of all or substantially all of Tenant’s assets;

(f)             Tenant files a voluntary petition under the United States Bankruptcy Code or any successor statute (the “ Code ”) or an order for relief is entered against Tenant pursuant to a voluntary or involuntary proceeding commenced under any chapter of the Code;

(g)            Any involuntary petition if filed against Tenant under any chapter of the Code and is not dismissed within one hundred twenty (120) days;

(h)            Failure to deliver an estoppel certificate within 5 days of the time period required in accordance with Section 28 ; or

(i)             Tenant’s interest in this Lease is attached, executed upon or otherwise judicially seized and such action is not released within one hundred twenty (120) days of the action.

(j)             Notices given under this Section 23.4 shall specify the alleged default and shall demand that Tenant perform the provisions of this Lease or pay the Rent that is in arrears, as the case may be, within the applicable period of time, or quit the Premises.  No such notice shall be deemed a forfeiture or a termination of this Lease unless Landlord elects otherwise in such notice.

(k)            Notwithstanding any other provision in this Section 23.4 , in the event the occurrence of any of the events specified in subparagraphs (a) through (j) above cause a condition that poses an imminent threat to the public health, safety or welfare, the applicable cure periods set forth in such subparagraph shall not apply, and the occurrence of such event shall immediately constitute a material “Default” hereunder.

23.5.         In the event of a Default by Tenant, and at any time thereafter, with or without notice or demand and without limiting Landlord in the exercise of any right or remedy that Landlord may have, Landlord shall be entitled to terminate Tenant’s right to possession of the Premises by any lawful means, in which case this Lease shall terminate and Tenant shall immediately surrender possession of the Premises to Landlord.  In such event, Landlord shall have the immediate right to re-enter and remove all persons and property, and such property may be removed and stored in a public warehouse or elsewhere at the cost and for the account of Tenant, all without service of notice or resort to legal process and without being deemed guilty of trespass or becoming liable for any loss or damage that may be occasioned thereby.  In the event that Landlord shall elect to so terminate this Lease, then Landlord shall be entitled to recover from

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Tenant all damages incurred by Landlord by reason of Tenant’s default, including, without limitation:

 

(a)           The worth at the time of award of any unpaid Rent that had accrued at the time of such termination; plus

(b)           The worth at the time of award of the amount by which the unpaid Rent that would have accrued during the period commencing with termination of the Lease and ending at the time of award exceeds that portion of the loss of Landlord s rental income from the Premises that Tenant proves to Landlord s reasonable satisfaction could have been reasonably avoided; plus

(c)           The worth at the time of award of the amount by which the unpaid Rent for the balance of the Term after the time of award exceeds that portion of the loss of Landlord’s rental income from the Premises that Tenant proves to Landlord s reasonable satisfaction could have been reasonably avoided; plus

(d)           Any other amount necessary to compensate Landlord for all the detriment proximately caused by Tenant’s failure to perform its obligations under this Lease or that in the ordinary course of things would be likely to result therefrom, including, without limitation, the cost of restoring the Premises to the condition required under the terms of this Lease; plus

(e)           At Landlord’s election, such other amounts in addition to or in lieu of the foregoing as may be permitted from time to time by Applicable Laws.

As used in Subsections 23.5(a) and 23.5(b) , “worth at the time of award” shall be computed by allowing interest at the rate specified in Section 23.1 . As used in Subsection 23.5(c) above, the “worth at the time of the award” shall be computed by taking the present value of such amount, using the discount rate of the Federal Reserve Bank of San Francisco at the time of the award plus one (1) percentage points.

23.6.         If Landlord does not elect to terminate this Lease as provided in Section 23.5 , then Landlord may, from time to time, recover all Rent as it becomes due under this Lease.  At any time thereafter, Landlord may elect to terminate this Lease and to recover damages to which Landlord is entitled.

23.7.         In the event Landlord elects to terminate this Lease and relet the Premises, Landlord may execute any new lease in its own name.  Tenant hereunder shall have no right or authority whatsoever to collect any Rent from such tenant.  The proceeds of any such reletting shall be applied as follows:

(a)           First, to the payment of any indebtedness other than Rent due hereunder from Tenant to Landlord, including, without limitation, storage charges or brokerage commissions owing from Tenant to Landlord as the result of such reletting;

(b)           Second, to the payment of the costs and expenses of reletting the Premises, including (i) alterations and repairs that Landlord deems reasonably necessary and advisable and (ii) reasonable attorneys’ fees, charges and disbursements incurred by Landlord in connection with the retaking of the Premises and such reletting;

(c)           Third, to the payment of Rent and other charges due and unpaid hereunder; and

(d)           Fourth, to the payment of future Rent and other damages payable by Tenant under this Lease.

23.8.         All of Landlord’s rights, options and remedies hereunder shall be construed and held to be nonexclusive and cumulative.  Landlord shall have the right to pursue any one or all of such remedies, or any other remedy or relief that may be provided by Applicable Laws, whether or not stated in this Lease. No waiver of any default of Tenant hereunder shall be implied from any acceptance by Landlord of any Rent or other payments due hereunder or any omission by Landlord to take any action on account of such default if such default persists or is repeated, and no express waiver shall affect defaults other than as specified in said waiver.

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23.9.         Landlord’s termination of (a) this Lease or (b) Tenant’s right to possession of the Premises shall not relieve Tenant of any liability to Landlord that has previously accrued or that shall arise based upon events that occurred prior to the later to occur of (i) the date of Lease termination or (ii) the date Tenant surrenders possession of the Premises.

23.10.       To the extent permitted by Applicable Laws, Tenant waives any and all rights of redemption granted by or under any present or future Applicable Laws if Tenant is evicted or dispossessed for any cause, or if Landlord obtains possession of the Premises due to Tenant’s default hereunder or otherwise.

23.11.       Landlord shall not be in default under this Lease unless Landlord fails to perform obligations required of Landlord within a reasonable time, but in no event shall such failure to continue for more than thirty (30) days after written notice from Tenant specifying the nature of Landlord’s failure; provided , however , that if the nature of Landlord’s obligation is such that more than thirty (30) days are required for its performance, then Landlord shall not be in default if Landlord commences performance within such thirty (30) day period and thereafter diligently prosecutes the same to completion.

23.12.       In the event of any default by Landlord, Tenant shall give notice by registered or certified mail to any (a) beneficiary of a deed of trust or (b) mortgagee under a mortgage covering the Premises or any portion thereof and to any landlord of any lease of land upon or within which the Premises are located, and shall offer such beneficiary, mortgagee or landlord a reasonable opportunity to cure the default, including time to obtain possession of the Premises by power of sale or a judicial action if such should prove necessary to effect a cure; provided that Landlord shall promptly furnish to Tenant in writing, upon written request by Tenant, the names and addresses of all such persons who are to receive such notices.

24.            Assignment or Subletting .

24.1.         Except as hereinafter provided, Tenant shall not, either voluntarily or by operation of Applicable Laws, directly or indirectly sell, hypothecate, assign, pledge, encumber or otherwise transfer this Lease, or sublet the Premises or any part hereof (each, a “ Transfer ”), without Landlord’s prior written consent, which consent Landlord may not unreasonably withhold or delay; provided that, without the consent of Landlord, Tenant may assign this Lease to a party that acquires substantially all the assets of or equity in Tenant.

24.2.         In the event Tenant desires to effect a Transfer, then, at least forty-five (45) but not more than ninety (90) days prior to the date when Tenant desires the assignment or sublease to be effective (the “ Assignment Date ”), Tenant shall provide written notice to Landlord (the “ Assignment Notice ”) containing information (including references) concerning the character of the proposed transferee, assignee or sublessee; the Assignment Date; any ownership or commercial relationship between Tenant and the proposed transferee, assignee or sublessee; and the consideration and all other material terms and conditions of the proposed Transfer, all in such detail as Landlord shall reasonably require. Tenant shall also tender to Landlord reasonable attorneys’ fees and other costs or overhead expenses incurred by Landlord in reviewing Tenant’s request for such Transfer; provided that such costs and expenses shall not exceed $2,000.00.

24.3.         Landlord, in determining whether consent should be given to a proposed Transfer, may give consideration to the financial strength of such transferee, assignee or sublessee (notwithstanding Tenant remaining liable for Tenant’s performance), any change in use that such transferee, assignee or sublessee proposes to make in the use of the Premises.  In no event shall Landlord be deemed to be unreasonable for declining to consent to a Transfer to a transferee, assignee or sublessee of poor reputation, lacking financial qualifications, seeking a material change in the Permitted Use, or jeopardizing directly or indirectly the status of Landlord or any of Landlord’s affiliates as a Real Estate Investment Trust under the Code.

24.4.         As conditions precedent to Tenant subleasing or transferring any rights to the Premises, Landlord may require any or all of the following:

(a)           Tenant shall remain fully liable under this Lease during the unexpired Term;

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(b)           Tenant shall provide Landlord with evidence reasonably satisfactory to Landlord respecting the relevant business experience and financial responsibility and status of the proposed transferee, assignee or sublessee;

(c)           Tenant shall reimburse Landlord for Landlord’s actual costs and expenses, including, without limitation, reasonable attorneys’ fees, charges and disbursements incurred in connection with the review, processing and documentation of such request; provided that such costs and expenses shall not exceed $2,000.00.

(d)           If Tenant’s transfer of rights or sharing of the Premises provides for the receipt by, on behalf of or on account of Tenant of any consideration of any kind whatsoever (including, without limitation, a premium rental for a sublease or lump sum payment for an assignment, but excluding Tenant’s reasonable costs in marketing and subleasing the Premises) in excess of the rental and other charges due to Landlord under this Lease, Tenant shall pay fifty percent (50%) of all of such excess to Landlord, after deductions for any transaction costs incurred by Tenant, including marketing expenses, tenant improvement allowances, alterations, cash concessions, brokerage commissions, attorneys’ fees and free rent..  If said consideration consists of cash paid to Tenant, payment to Landlord shall be made upon receipt by Tenant of such cash payment;

(e)           The proposed transferee, assignee or sublessee shall agree that, in the event Landlord gives such proposed transferee, assignee or sublessee notice that Tenant is in default under this Lease, such proposed transferee, assignee or sublessee shall thereafter make all payments otherwise due Tenant directly to Landlord, which payments shall be received by Landlord without any liability being incurred by Landlord, except to credit such payment against those due by Tenant under this Lease, and any such proposed transferee, assignee or sublessee shall agree to attorn to Landlord or its successors and assigns should this Lease be terminated for any reason; provided , however , that in no event shall Landlord or its Lenders, successors or assigns be obligated to accept such attornment;

(f)            Any such Transfer shall be effected on Landlord’s forms;

(g)           Tenant shall not then be in material default hereunder in any respect;

(h)           Landlord shall not be bound by any provision of any agreement pertaining to the Transfer, without Landlord’s written agreement to the same;

(i)            Tenant shall deliver to Landlord one executed copy of any and all written instruments evidencing the Transfer; and

(j)            A list of Hazardous Materials (as defined in Section 38.7 below), certified by the proposed transferee, assignee or sublessee to be true and correct, that the proposed transferee, assignee or sublessee intends to use or store in the Premises.  Additionally, Tenant shall deliver to Landlord, on or before the date any proposed transferee, assignee or sublessee takes occupancy of the Premises, all of the items relating to Hazardous Materials of such proposed transferee, assignee or sublessee as described in Section 38.2 .

24.5.         Any Transfer that is not in compliance with the provisions of this Section 24 shall be void and shall, at the option of Landlord, terminate this Lease.

24.6.         The consent by Landlord to a Transfer shall not relieve Tenant or proposed transferee, assignee or sublessee from obtaining Landlord’s consent to any further Transfer, nor shall it release Tenant or any proposed transferee, assignee or sublessee of Tenant from full and primary liability under this Lease unless otherwise agreed in writing by Landlord.

24.7.         Notwithstanding any Transfer, Tenant shall remain fully and primarily liable for the payment of all Rent and other sums due or to become due hereunder, and for the full performance of all other terms, conditions and covenants to be kept and performed by Tenant, unless otherwise agreed in writing by Landlord.  The acceptance of Rent or any other sum due hereunder, or the acceptance of performance of any other term, covenant or condition thereof, from any person or entity other than Tenant shall not be deemed a waiver of any of the provisions of this Lease or a consent to any Transfer.

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24.8.         If Tenant delivers to Landlord an Assignment Notice indicating a desire to transfer this Lease to a proposed transferee, assignee or sublessee other than as provided within Section 24.4 , then Landlord shall have the option, exercisable by giving notice to Tenant at any time within ten (10) days after Landlord’s receipt of such Assignment Notice, to terminate this Lease as of the date specified in the Assignment Notice as the Assignment Date, except for those provisions that, by their express terms, survive the expiration or earlier termination hereof.  If Landlord exercises such option, then Tenant shall have the right to withdraw such Assignment Notice by delivering to Landlord written notice of such election within five (5) days after Landlord’s delivery of notice electing to exercise Landlord’s option to terminate this Lease.  In the event Tenant withdraws the Assignment Notice as provided in this Section 24.8 , this Lease shall continue in full force and effect. No failure of Landlord to exercise its option to terminate this Lease shall be deemed to be Landlord’s consent to a proposed Transfer.

24.9.         If Tenant sublets the Premises or any portion thereof, Tenant hereby immediately and irrevocably assigns to Landlord, as security for Tenant’s obligations under this Lease, all rent from any such subletting, and appoints Landlord as assignee and attorney-in-fact for Tenant, and Landlord (or a receiver for Tenant appointed on Landlord’s application) may collect such rent and apply it toward Tenant’s obligations under this Lease; provided that, until the occurrence of a Default by Tenant, Tenant shall have the right to collect such rent.

25.            Attorneys’ Fees . If either party commences an action against the other party arising out of or in connection with this Lease, then the prevailing party shall be entitled to have and recover from the non-prevailing party reasonable attorneys’ fees, charges and disbursements and costs of suit.

26.            Bankruptcy . In the event a debtor, trustee or debtor in possession under the Code, or another person with similar rights, duties and powers under any other Applicable Laws, proposes to cure any default under this Lease or to assume or assign this Lease and is obliged to provide adequate assurance to Landlord that (a) a default shall be cured, (b) Landlord shall be compensated for its damages arising from any breach of this Lease and (c) future performance of Tenant’s obligations under this Lease shall occur, then such adequate assurances shall include any or all of the following, as designated by Landlord in its sole and absolute discretion:

26.1.         Those acts specified in the Code or other Applicable Laws as included within the meaning of “adequate assurance,” even if this Lease does not concern a shopping center or other facility described in such Applicable Laws;

26.2.         A prompt cash payment to compensate Landlord for any monetary defaults or actual damages arising directly from a breach of this Lease;

26.3.         A cash deposit in an amount at least equal to the then-current amount of the Security Deposit; or

26.4.         The assumption or assignment of all of Tenant’s interest and obligations under this Lease.

27.            Definition of Landlord . With regard to obligations imposed upon Landlord pursuant to this Lease, the term “ Landlord ,” as used in this Lease, shall refer only to Landlord or Landlord’s then-current successor-in-interest.  In the event of any transfer, assignment or conveyance of Landlord’s interest in this Lease or in Landlord’s fee title to or leasehold interest in the Property, as applicable, the Landlord herein named (and in case of any subsequent transfers or conveyances, the subsequent Landlord) shall be automatically freed and relieved, from and after the date of such transfer, assignment or conveyance, from all liability for the performance of any covenants or obligations contained in this Lease thereafter to be performed by Landlord and, without further agreement, the transferee, assignee or conveyee of Landlord’s in this Lease or in Landlord’s fee title to or leasehold interest in the Property, as applicable, shall be deemed to have assumed and agreed to observe and perform any and all covenants and obligations of Landlord hereunder during the tenure of its interest in the Lease or the Property.  Landlord or any subsequent Landlord may transfer its interest in the Premises or this Lease without Tenant’s consent.

28.            Estoppel Certificate . Tenant shall, within ten (10) days of receipt of written notice from Landlord, execute, acknowledge and deliver a statement in writing substantially in the form attached to this Lease as Exhibit E , or on any other form reasonably requested by a proposed

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Lender or purchaser, (a) certifying that this Lease is unmodified and in full force and effect (or, if modified, stating the nature of such modification and certifying that this Lease as so modified is in full force and effect) and the dates to which rental and other charges are paid in advance, if any, (b) acknowledging that there are not, to Tenant’s knowledge, any uncured defaults on the part of Landlord hereunder, or specifying such defaults if any are claimed, and (c) setting forth such further information with respect to this Lease or the Premises as may be requested thereon.  Any such statement may be relied upon by any prospective purchaser or encumbrancer of all or any portion of the real property of which the Premises are a part.  Tenant’s failure to deliver such statement within 5 days of the prescribed time shall, at Landlord’s option, constitute a Default under this Lease, and, in any event, shall be binding upon Tenant that the Lease is in full force and effect and without modification except as may be represented by Landlord in any certificate prepared by Landlord and delivered to Tenant for execution.

29.            Joint and Several Obligations . If more than one person or entity executes this Lease as Tenant, then:

29.1.         Each of them is jointly and severally liable for the keeping, observing and performing of all of the terms, covenants, conditions, provisions and agreements of this Lease to be kept, observed or performed by Tenant; and

29.2.         The term “ Tenant ” as used in this Lease shall mean and include each of them, jointly and severally. The act of, notice from, notice to, refund to, or signature of any one or more of them with respect to the tenancy under this Lease, including, without limitation, any renewal, extension, expiration, termination or modification of this Lease, shall be binding upon each and all of the persons executing this Lease as Tenant with the same force and effect as if each and all of them had so acted, so given or received such notice or refund, or so signed.

30.            Limitation of Landlord’s Liability .

30.1.         If Landlord is in default under this Lease and, as a consequence, Tenant recovers a monetary judgment against Landlord, the judgment shall be satisfied only out of (a) the proceeds of sale received on execution of the judgment and levy against the right, title and interest of Landlord in the Premises, (b) rent or other income from such real property receivable by Landlord or (c) the consideration received by Landlord from the sale, financing, refinancing or other disposition of all or any part of Landlord’s right, title or interest in the Premises.

30.2.         If Landlord is a partnership or joint venture, then the partners of such partnership shall not be personally liable for Landlord’s obligations under this Lease, and no partner of Landlord shall be sued or named as a party in any suit or action, and service of process shall not be made against any partner of Landlord except as may be necessary to secure jurisdiction of the partnership or joint venture.  If Landlord is a corporation, then the shareholders, directors, officers, employees and agents of such corporation shall not be personally liable for Landlord’s obligations under this Lease, and no shareholder, director, officer, employee or agent of Landlord shall be sued or named as a party in any suit or action, and service of process shall not be made against any shareholder, director, officer, employee or agent of Landlord, except as may be necessary to secure jurisdiction of the corporation. If Landlord is a limited liability company, then the members of such limited liability company shall not be personally liable for Landlord’s obligations under this Lease, and no member of Landlord shall be sued or named as a party in any suit or action, and service of process shall not be made against any member of Landlord except as may be necessary to secure jurisdiction of the limited liability company.  No partner, shareholder, director, employee, member or agent of Landlord shall be required to answer or otherwise plead to any service of process, and no judgment shall be taken or writ of execution levied against any partner, shareholder, director, employee or agent of Landlord.

30.3.         Each of the covenants and agreements of this Section 30 shall be applicable to any covenant or agreement either expressly contained in this Lease or imposed by Applicable Laws and shall survive the expiration or earlier termination of this Lease.

31.            Premises Control by Landlord .

31.1.         Landlord reserves full control over the Premises to the extent not inconsistent with Tenant’s enjoyment of the same as provided by this Lease.  This reservation includes, without limitation, Landlord’s right to subdivide the Property, convert the Building to condominium units,

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grant easements and licenses to third parties, and maintain or establish ownership of the Building separate from fee title to the Property.

 

31.2.         Tenant shall, at Landlord’s request, promptly execute such further documents as may be reasonably appropriate to assist Landlord in the performance of its obligations hereunder; provided that Tenant need not execute any document that creates additional liability for Tenant or that deprives Tenant of the quiet enjoyment and use of the Premises as provided by this Lease.

31.3.         Landlord may, at any and all reasonable times during non-business hours (or during business hours if Tenant so requests), and upon twenty-four (24) hours’ prior notice ( provided that no time restrictions shall apply or advance notice be required if an emergency necessitates immediate entry), enter the Premises to (a) inspect the same and to determine whether Tenant is in compliance with its obligations hereunder, (b) supply any service Landlord is required to provide hereunder, (c) show the Premises to prospective purchasers or tenants during the final year of the Term, (d) post notices of nonresponsibility and (e) access the telephone equipment, electrical substation and fire risers. In connection with any such alteration, improvement or repair as described in  Section 17.4 above, Landlord may erect in the Premises scaffolding and other structures reasonably required for the alteration, improvement or repair work to be performed.  In no event shall Tenant’s Rent abate as a result of Landlord’s activities pursuant to this Section 31.3 ; provided , however , that all such activities shall be conducted in such a manner so as to cause as little interference to Tenant as is reasonably possible, and such activities shall not materially interfere with Tenant’s use and quiet enjoyment of the Premises.  Landlord shall at all times retain a key with which to unlock all of the doors in the Premises.  If an emergency necessitates immediate access to the Premises, Landlord may use whatever force is necessary to enter the Premises, and any such entry to the Premises shall not constitute a forcible or unlawful entry to the Premises, a detainer of the Premises, or an eviction of Tenant from the Premises or any portion thereof.

32.            Quiet Enjoyment . So long as Tenant is not in default under this Lease, Landlord or anyone acting through or under Landlord shall not disturb Tenant’s occupancy of the Premises, except as permitted by this Lease.

33.            Subordination and Attornment .

33.1.         This Lease shall be subject and subordinate to the lien of any mortgage, deed of trust, or lease in which Landlord is tenant now or hereafter in force against the Premises or any portion thereof and to all advances made or hereafter to be made upon the security thereof without the necessity of the execution and delivery of any further instruments on the part of Tenant to effectuate such subordination.

33.2.         Notwithstanding the foregoing, Tenant shall execute and deliver upon demand such further instrument or instruments evidencing such subordination of this Lease to the lien of any such mortgage or mortgages or deeds of trust or lease in which Landlord is tenant as may be required by Landlord. However, if any such mortgagee, beneficiary or Landlord under lease wherein Landlord is tenant so elects, this Lease shall be deemed prior in lien to any such lease, mortgage, or deed of trust upon or including the Premises regardless of date and Tenant shall execute a statement in writing to such effect at Landlord’s request.  If Tenant fails to execute any document required from Tenant under this Section within ten (10) days after written request therefor, Tenant hereby constitutes and appoints Landlord or its special attorney-in-fact to execute and deliver any such document or documents in the name of Tenant.  Such power is coupled with an interest and is irrevocable.

33.3.         In the event any proceedings are brought for foreclosure, or in the event of the exercise of the power of sale under any mortgage or deed of trust made by the Landlord covering the Premises, the Tenant shall at the election of the purchaser at such foreclosure or sale attorn to the purchaser upon any such foreclosure or sale and recognize such purchaser as the Landlord under this Lease.

33.4.         Notwithstanding anything to the contrary contained herein, so long as Tenant is not in default under this Lease, its peaceful use and occupancy of the Premises under this Lease shall not be impaired, restricted or terminated by any mortgagee, grand lessor, beneficiary, or secured party.

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34.            Surrender .

34.1.         No surrender of possession of any part of the Premises shall release Tenant from any of its obligations hereunder, unless such surrender is accepted in writing by Landlord.

34.2.         The voluntary or other surrender of this Lease by Tenant shall not effect a merger with Landlord’s fee title or leasehold interest in the Premises or any portion thereof, unless Landlord consents in writing, and shall, at Landlord’s option, operate as an assignment to Landlord of any or all subleases.

34.3.         The voluntary or other surrender of any ground or other underlying lease that now exists or may hereafter be executed affecting the Premises or any portion thereof, or a mutual cancellation thereof or of Landlord’s interest therein by Landlord and its lessor shall not effect a merger with Landlord’s fee title or leasehold interest in the Premises and shall, at the option of the successor to Landlord’s interest in the Premises or any portion thereof operate as an assignment of this Lease.

35.            Waiver and Modification . No provision of this Lease may be modified, amended or supplemented except by an agreement in writing signed by Landlord and Tenant.  The waiver by Landlord of any breach by Tenant of any term, covenant or condition herein contained shall not be deemed to be a waiver of any subsequent breach of the same or any other term, covenant or condition herein contained.

36.            Waiver of Jury Trial and Counterclaims . The parties waive trial by jury in any action, proceeding or counterclaim brought by the other party hereto related to matters arising out of or in any way connected with this Lease; the relationship between Landlord and Tenant; Tenant’s use or occupancy of the Premises; or any claim of injury or damage related to this Lease or the Premises.

37.            [Intentionally omitted]

38.            Hazardous Materials .

38.1.         Tenant shall not cause or permit any Hazardous Materials (as hereinafter defined) to be brought upon, kept or used in or about the Premises in violation of Applicable Laws by Tenant, its agents, employees, contractors or invitees.  If Tenant breaches such obligation, or if the presence of Hazardous Materials as a result of such a breach results in contamination of the Premises or any adjacent property, or if contamination of the Premises or any adjacent property by Hazardous Materials is caused by Tenant or its agents, contractors, invitees or employees during the term of this Lease or any extension or renewal hereof or holding over hereunder, then Tenant shall indemnify, save, defend and hold Landlord, its agents and contractors harmless from and against any and all claims, judgments, damages, penalties, fines, costs, liabilities and losses (including, without limitation, diminution in value of the Premises or any portion thereof; damages for the loss or restriction on use of rentable or usable space or of any amenity of the Premises; damages arising from any adverse impact on marketing of space in the Premises; and sums paid in settlement of claims, attorneys’ fees, consultants’ fees and experts’ fees) that arise during or after the Term as a result of such breach or contamination.  This indemnification of Landlord by Tenant includes, without limitation, costs incurred in connection with any investigation of site conditions or any cleanup, remedial, removal or restoration work required by any Governmental Authority because of Hazardous Materials present in the air, soil or groundwater above, on or under the Premises.  Without limiting the foregoing, if the presence of any Hazardous Materials in, on, under or about the Premises or any adjacent property caused or permitted by Tenant results in any contamination of the Premises or any adjacent property, then Tenant shall promptly take all actions at its sole cost and expense as are necessary to return the Premises and any adjacent property to their respective condition existing prior to the time of such contamination; provided that Landlord’s written approval of such action shall first be obtained, which approval Landlord shall not unreasonably withhold or delay; and provided , further, that it shall be reasonable for Landlord to withhold its consent if such actions could have a material adverse long-term or short-term effect on the Premises.

38.2.         Landlord acknowledges that it is not the intent of this Section 38 to prohibit Tenant from operating its business as described in Section 2.8 above. Tenant may operate its business according to the custom of Tenant’s industry so long as the use or presence of Hazardous Materials is strictly and properly monitored according to Applicable Laws.  As a material inducement to

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Landlord to allow Tenant to use Hazardous Materials in connection with its business, Tenant has delivered to Landlord prior to the Term Commencement Date a list identifying each type of Hazardous Material to be present on the Premises and setting forth any and all governmental approvals or permits required in connection with the presence of such Hazardous Material on the Premises (the “ Hazardous Materials List ”). Tenant shall deliver to Landlord an updated Hazardous Materials List: (a) upon any contamination of the Premises; or (b) upon the request of Landlord, which Landlord shall not request more than once per year.  Tenant shall deliver to Landlord true and correct copies of the following documents (hereinafter referred to as the “ Documents ”) relating to the handling, storage, disposal and emission of Hazardous Materials prior to the Term Commencement Date or, if unavailable at that time, concurrent with the receipt from or submission to any Governmental Authority:  permits; approvals; reports and correspondence; storage and management plans; notices of violations of Applicable Laws; plans relating to the installation of any storage tanks to be installed in or under the Premises ( provided that installation of below-ground storage tanks shall only be permitted after Landlord has given Tenant its written consent to do so, which consent Landlord may withhold in its sole and absolute discretion); and all closure plans or any other documents required by any and all Governmental Authorities for any storage tanks installed in, on or under the Premises for the closure of any such storage tanks. Tenant shall not be required, however, to provide Landlord with any portion of the Documents containing information of a proprietary nature that, in and of themselves, do not contain a reference to any Hazardous Materials or activities related to Hazardous Materials.

38.3.         Notwithstanding the provisions of Section 38.1 above, if (a) any proposed transferee, assignee or sublessee of Tenant has been required by any prior landlord, Lender or Governmental Authority to take remedial action in connection with Hazardous Materials contaminating a property if the contamination resulted from such party’s action or omission or use of the property in question or (ii) any proposed transferee, assignee or sublessee is subject to an enforcement order issued by any Governmental Authority in connection with the use, disposal or storage of Hazardous Materials, then it shall not be unreasonable for Landlord to withhold its consent to any proposed transfer, assignment or subletting (with respect to any such matter involving a proposed transferee, assignee or sublessee).

38.4.         At any time, and from time to time,  prior to the expiration of the Term, Landlord shall have the right to conduct appropriate tests of the Premises to demonstrate that Hazardous Materials are present or that contamination has occurred due to Tenant or Tenant’s agents, employees or invitees.  Tenant shall pay all reasonable costs of such tests of the Premises.

38.5.         If underground or other storage tanks storing Hazardous Materials are located on the Premises or are hereafter placed on the Premises by any party, Tenant shall monitor the storage tanks, maintain appropriate records, implement reporting procedures, properly close any underground storage tanks, and take or cause to be taken all other steps necessary or required under the Applicable Laws.

38.6.         Tenant’s obligations under this Section 38 shall survive the expiration or earlier termination of the Lease.  During any period of time needed by Tenant or Landlord after the termination of this Lease to complete the removal from the Premises of any such Hazardous Materials, Tenant shall continue to pay Rent in accordance with this Lease, which Rent shall be prorated daily, but only to the extent that the Premises are rendered untenantable by such activity.

38.7.         As used herein, the term “ Hazardous Material ” means any hazardous or toxic substance, material or waste that is or becomes regulated by any Governmental Authority.

39.            [Intentionally omitted]

40.            Miscellaneous .

40.1.         This Lease shall be deemed and construed to be an “absolute net lease” and, except as herein expressly provided, Landlord shall receive all payments required to be made by Tenant free from all charges, assessments, impositions, expenses and deductions of any and every kind or nature whatsoever. Landlord shall not be required to furnish any services or facilities or to make any repairs, replacements or alterations of any kind in or on the Premises except as specifically provided herein. Tenant shall receive all invoices and bills relative to the Premises and, except as otherwise provided herein, shall pay for all expenses directly to the person or company submitting a bill without first having to forward payment for the expenses to Landlord.  Tenant shall at

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Tenant’s sole cost and expense be responsible for the management of the Premises, shall maintain the landscaping and parking lot, and shall make those additional repairs and alterations required of Tenant hereunder to maintain the Premises in good order, condition and repair subject to the conditions of the Premises as of the Term Commencement Date.

 

40.2.         Where applicable in this Lease, the singular includes the plural and the masculine or neuter includes the masculine, feminine and neuter.  The section headings of this Lease are not a part of this Lease and shall have no effect upon the construction or interpretation of any part hereof.

40.3.         Submission of this instrument for examination or signature by Tenant does not constitute a reservation of or option for a lease, and shall not be effective as a lease or otherwise until execution by and delivery to both Landlord and Tenant.

40.4.         Time is of the essence with respect to the performance of every provision of this Lease in which time of performance is a factor.

40.5.         Each provision of this Lease performable by Tenant shall be deemed both a covenant and a condition.

40.6.         Whenever consent or approval of either party is required, that party shall not unreasonably withhold such consent or approval, except as may be expressly set forth to the contrary.

40.7.         The terms of this Lease are intended by the parties as a final expression of their agreement with respect to the terms as are included herein, and may not be contradicted by evidence of any prior or contemporaneous agreement.

40.8.         Any provision of this Lease that shall prove to be invalid, void or illegal shall in no way affect, impair or invalidate any other provision hereof, and all other provisions of this Lease shall remain in full force and effect and shall be interpreted as if the invalid, void or illegal provision did not exist.

40.9.         Landlord may, but shall not be obligated to, record this Lease or a short form memorandum hereof without Tenant’s consent.  Neither party shall record this Lease.  Tenant shall be responsible for the cost of recording any memorandum of this Lease, including any transfer or other taxes incurred in connection with said recordation.

40.10.       The language in all parts of this Lease shall be in all cases construed as a whole according to its fair meaning and not strictly for or against either Landlord or Tenant.

40.11.       Each of the covenants, conditions and agreements herein contained shall inure to the benefit of and shall apply to and be binding upon the parties hereto and their respective heirs; legatees; devisees; executors; administrators; and permitted successors, assigns, sublessees. Nothing in this Section 40.11 shall in any way alter the provisions of this Lease restricting assignment or subletting.

40.12.       Any notice, consent, demand, bill, statement or other communication required or permitted to be given hereunder shall be in writing and shall be given by personal delivery, overnight delivery with a reputable nationwide overnight delivery service, or certified mail (return receipt requested), and if given by personal delivery, shall be deemed delivered upon receipt; if given by overnight delivery, shall be deemed delivered one (1) day after deposit with a reputable nationwide overnight delivery service; and, if given by certified mail (return receipt requested), shall be deemed delivered two (2) days after the time the notifying party deposits the notice with the United States Postal Service.  Any notices given pursuant to this Lease shall be addressed to Tenant at the Premises, or to Landlord or Tenant at the addresses shown in Sections 2.10 and 2.11 , respectively. Either party may, by notice to the other given pursuant to this Section, specify additional or different addresses for notice purposes.

40.13.       This Lease shall be governed by, construed and enforced in accordance with the laws of the State in which the Premises are located, without regard to such State’s conflict of law principles.

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40.14.       That individual or those individuals signing this Lease guarantee, warrant and represent that said individual or individuals have the power, authority and legal capacity to sign this Lease on behalf of and to bind all entities, corporations, partnerships, limited liability companies, joint venturers or other organizations and entities on whose behalf said individual or individuals have signed.

40.15.       If not publicly available, Tenant agrees that it shall promptly furnish to Landlord, from time to time, upon Landlord’s written request, the most recent audited year-end financial statements reflecting Tenant’s current financial condition.  Tenant represents and warrants that all financial statements, records and information furnished by Tenant to Landlord in connection with this Lease are true, correct and complete in all respects.

40.16.       This Lease may be executed in one or more counterparts, each of which, when taken together, shall constitute one and the same document.

41.            Option to Extend Term . Tenant shall have the option (“ Option ”) to extend the Term of this Lease upon the following terms and conditions:

41.1.         Tenant shall have two (2) consecutive options to extend the Term of this Lease by five (5) years each (each, an “ Extended Term ”) on the same terms and conditions as this Lease, except that the Monthly Base Rent payable under this Lease shall be 95% of the Fair Market Rental Value.  “ Fair Market Rental Value ” shall mean the fair market value of laboratory/office space of similar age and finish in the Boulder, Colorado market taking into account all relevant factors, including without limitation, improvement allowances or rent concessions granted in connection with such other leases, provided, however, that in no event shall any leasehold improvement made by Tenant following the Commencement Date ever be considered in any valuation of the fair market value of the space.  The Basic Annual Rent of each Extended Term shall be subject to an annual upward adjustment of two percent (2%) of the then-current Basic Annual Rent.

41.2.         The Option is not assignable separate and apart from this Lease.

41.3.         The Option is conditional upon Tenant giving Landlord written notice of its election to exercise the Option at least twelve (12) months prior to the (i) expiration of the initial Term in the case of the first Extended Term, or (ii) expiration of the first Extended Term in the case of the second Extended Term.  If said notice is not delivered within said time period(s), the Option shall terminate.

41.4.         Within thirty (30) days after receiving Tenant’s notice extending the Term of this Lease pursuant to Section 41.3 above, Landlord shall provide Tenant with Landlord’s good faith estimate of 95% of the Fair Market Rental Value of the Premises for the Extended Term.  If Tenant is unwilling to accept Landlord’s estimate of the Fair Market Rental Value as set forth in Landlord’s notice referred to above, and the parties are unable to reach agreement thereon within thirty (30) days after the delivery of such notice by Landlord, then either party may obtain and deliver to the other party an independent appraisal of the Fair Market Rental Value of the Premises within ten (10) days after the expiration of such thirty (30) day period.  Within fifteen (15) days after receiving such party’s appraisal, the responding party may elect to obtain at its own expense and deliver to the initiating party a second independent appraisal of the Fair Market Rental Value of the Premises.  If the second appraiser shall not have been so appointed within such fifteen (15) day period, the Fair Market Rental Value of the Premises shall be determined by the initiating party’s appraisal. If the second appraiser shall have been so appointed, the two appraisers thus appointed shall, within fifteen (15) days after the responding party’s notice of appointment of the second appraiser, appoint a third appraiser.  If the two initial appraisers are unable timely to agree on the third appraiser, then either may, on behalf of both, request such appraiser by the Denver office of JAMS Inc., or its successor, or, on its failure, refusal or inability to act, by a court of competent jurisdiction.  Within fifteen (15) days after the appointment of the third appraiser, the Fair Market Rental Value of the Premises shall be the arithmetical average of the two appraisals closest in their determination of fair market rental value which amount shall be binding upon the parties. All appraisers shall be qualified MAI appraisers who are independent from the parties and have had at least ten (10) years commercial real estate experience in the greater Denver area and significant experience dealing with the laboratory space sub-market.  Each party shall pay the fees of its own appraiser, and the fees of the third appraiser shall be shared equally by the parties.

24




41.5.         Notwithstanding anything contained in this Section 41 , Tenant shall not have the right to exercise the Option:

(a)            During the time commencing from the date Landlord delivers to Tenant a written notice that Tenant is in default under any provisions of this Lease and continuing until Tenant has cured the specified default to Landlord’s reasonable satisfaction; or

(b)            At any time after an event of Default as described in Section 23.4 of the Lease (provided, however, that, for purposes of this Subsection 41.5(b) , Landlord shall not be required to provide Tenant with notice of such Default) and continuing until Tenant cures any such Default, if such Default is susceptible to being cured; or

(c)            In the event that Tenant has defaulted in the performance of its obligations under this Lease three (3) or more times and a service or late charge has become payable under Section 23.1 for each of such defaults during the twelve (12)-month period immediately prior to the date that Tenant intends to exercise the Option, whether or not Tenant has cured such defaults.

41.6.         The period of time within which Tenant may exercise the Option shall not be extended or enlarged by reason of Tenant’s inability to exercise the Option because of the provisions of Section 41.4 .

41.7.         All of Tenant’s rights under the provisions of the Option shall terminate and be of no further force or effect even after Tenant’s due and timely exercise of an Option if, after such exercise, but prior to the commencement date of the new term, (a) Tenant fails to pay to Landlord a monetary obligation of Tenant for a period of twenty (20) days after written notice from Landlord to Tenant , (b) Tenant fails to commence to cure a default (other than a monetary default) within thirty (30) days after the date Landlord gives notice to Tenant of such default or (c) Tenant has defaulted under this Lease three (3) or more times and a service or late charge under Section 23.1 has become payable for any such default during the immediately preceding 24-month period, whether or not Tenant has cured such defaults.

42.            Equal Termination Date Extension Option . In addition to the Option described in Section 41, Tenant shall also have an option to extend the Term of this lease, as the same may otherwise be extended pursuant to the terms hereof, so that the Lease Term shall expire upon the expiration of the term of the Longmont Lease (as defined below), as the term of the Longmont Lease may be extended from time to time (the “ Equal Termination Date Extension Option ”).

The “Longmont Lease” shall have the meaning as defined in that certain Assignment Agreement dated June 21, 2006, between Tenant and BioMed Realty, L.P.  The Equal Termination Date Extension Option is conditioned upon Tenant giving Landlord written notice of its election to exercise such Option at least 12 months prior to the expiration of the initial Term.

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25




IN WITNESS WHEREOF, the parties hereto have executed this Lease as of the date first above written.

LANDLORD :

 

 

BMR-3200 Walnut Street LLC,

a Delaware limited liability company

 

By:

BioMed Realty, L.P.,

 

a Maryland limited partnership,

 

its Member

 

 

 

 

 

 

 

 

Name:

 

Title:

 

TENANT :

 

Array BioPharma Inc.,

a Delaware corporation

 

By:

 

Name: Mike Carruthers

Title: CFO

 

26




EXHIBIT A

PREMISES

Premises : Lot 1, Synergen Subdivision Filing No. 3, County of Boulder, State of Colorado, the Plat of which was recorded November 7, 1996 on Film 2168 as Reception No. 1656392 in Plan File P-32, F-3, No. 25.




EXHIBIT B

ACKNOWLEDGEMENT OF TERM COMMENCEMENT DATE
AND TERM EXPIRATION DATE

THIS ACKNOWLEDGEMENT OF TERM COMMENCEMENT DATE AND TERM EXPIRATION DATE is entered into as of                             , 2006, with reference to that certain Lease (the “ Lease ”) dated as of                            , 2006 by Array BioPharma Inc., a Delaware corporation (“ Tenant ”), in favor of BMR-3200 Walnut Street LLC, a Delaware limited liability company (“ Landlord ”).  All capitalized terms used herein without definition shall have the meanings ascribed to them in the Lease.

Tenant hereby confirms the following:

1.             Tenant accepted possession of the Premises as-is on                            , 2006.

2.             The Premises are in good order, condition and repair except as described on Exhibit      of the Lease.

3.             The Tenant Improvements required to be constructed by Landlord under the Lease have been substantially completed.

4.             All conditions of the Lease to be performed by Landlord as a condition to the full effectiveness of the Lease have been satisfied, and Landlord has fulfilled all of its duties in the nature of inducements offered to Tenant to lease the Premises.

5.             The Term Commencement Date is           , 2006, and, unless the Lease is terminated prior to the Term Expiration Date pursuant to its terms, the Lease Expiration Date shall be              , 2016.

6.             Tenant commenced occupancy of the Premises under this Lease for the Permitted Use on                  , 2006.

7.             The Lease is in full force and effect, and the same represents the entire agreement between Landlord and Tenant concerning the Premises[, except [              ]].

8.             Tenant has no existing defenses against the enforcement of the Lease by Landlord, and there exist no offsets or credits against Rent owed or to be owed by Tenant.

9.             The obligation to pay Rent is presently in effect and all Rent obligations on the part of Tenant under the Lease commenced to accrue on [              ], 20[    ].

10.           The undersigned Tenant has not made any prior assignment, transfer, hypothecation or pledge of the Lease or of the rents thereunder or sublease of the Premises or any portion thereof.

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IN WITNESS WHEREOF, the parties hereto have executed this Acknowledgment of Term Commencement Date and Term Expiration Date as of [              ], 2016.

 

TENANT:

 

ARRAY BIOPHARMA INC.,

a Delaware corporation

 

By:

 

 

Name:

 

 

Title:

 

 

 




EXHIBIT C

 

TENANT’S PERSONAL PROPERTY

Tenant s Personal Property includes all non-attached furniture, fixtures and equipment.  In addition, for purposes of this Lease, Tenant Personal Property shall also include attached trade fixtures, equipment and improvements installed by Tenant prior to the Effective Date (the Additional Tenant Property ). The Additional Tenant Property shall be transferred to and owned by Landlord at the end of the Lease Term.




EXHIBIT D

 

RULES AND REGULATIONS

NOTHING IN THESE RULES AND REGULATIONS (“ RULES AND REGULATIONS ”) SHALL SUPPLANT ANY PROVISION OF THE LEASE.  IN THE EVENT OF A CONFLICT OR INCONSISTENCY BETWEEN THESE RULES AND REGULATIONS AND THE LEASE, THE LEASE SHALL PREVAIL.

1.             Except as specifically provided in the Lease to which these Rules and Regulations are attached, no sign, placard, picture, advertisement, name or notice shall be installed or displayed on any part of the outside of the Premises or the Building without Landlord’s prior written consent. Landlord shall have the right to remove, at Tenant’s sole cost and expense and without notice, any sign installed or displayed in violation of this rule.

2.             Tenant shall not obstruct any sidewalks or entrances to the Building, or any halls, passages, exits, entrances or stairways within the Premises, in any case that are required to be kept clear for health and safety reasons.

3.             No deliveries shall be made that impede or interfere with operation of the Premises.

4.             Tenant shall not place a load upon any floor of the Premises that exceeds the load per square foot that (a) such floor was designed to carry or (b) that is allowed by Applicable Laws.

5.             Tenant shall not install any radio, television or other antenna, cell or other communications equipment, or any other devices on the roof or exterior walls of the Premises except to the extent shown on approved Tenant Improvements plans.  Tenant shall not interfere with radio, television or other communications from or in the Premises or elsewhere.

6.             Canvassing, peddling, soliciting and distributing handbills or any other written material within, on or around the Premises are prohibited, and Tenant shall cooperate to prevent such activities.

7.             Tenant shall store all of its trash, garbage and Hazardous Materials within its Premises or in designated receptacles outside of the Premises.  Tenant shall not place in any such receptacle any material that cannot be disposed of in the ordinary and customary manner of trash, garbage and Hazardous Materials disposal.

8.             The Premises shall not be used for any improper or illegal purpose.

9.             Tenant shall not, without Landlord’s prior written consent, use the name of the Premises, if any, in connection with or in promoting or advertising Tenant’s business except as Tenant’s address.

10.           Tenant shall comply with all safety, fire protection and evacuation procedures and regulations established by Landlord or any Governmental Authority.

11.           Tenant assumes any and all responsibility for protecting the Premises from theft, robbery and pilferage, which responsibility includes keeping doors locked and other means of entry to the Premises closed.

12.           Landlord may waive any one or more of these Rules and Regulations for the benefit of Tenant, but no such waiver by Landlord shall prevent Landlord from thereafter enforcing any such Rules and Regulations against Tenant.

13.           These Rules and Regulations are in addition to, and shall not be construed to in any way modify or amend, in whole or in part, the terms covenants, agreements and conditions of the Lease.

14.           Landlord reserves the right to make such other and reasonable rules and regulations as, in its judgment, may from time to time be needed for safety and security, the care and cleanliness of the Premises, or the preservation of good order therein; provided , however , that Landlord shall provide written notice to Tenant of such rules and regulations prior to them taking effect and these Rules and Regulations shall not materially interfere with Tenant’s use and quiet enjoyment of the




Premises. Tenant agrees to abide by these Rules and Regulations and any additional rules and regulations issued or adopted by Landlord.

 

15.           Tenant shall be responsible for the observance of these Rules and Regulations by Tenant’s employees, agents, clients, customers, invitees and guests.




EXHIBIT E

 

FORM OF ESTOPPEL CERTIFICATE

To:

BMR-3200 Walnut Street LLC

 

17140 Bernardo Center Drive, Suite 222

 

San Diego, CA 92128

 

Attention: General Counsel

 

 

 

BioMed Realty, L.P.

 

c/o BioMed Realty Trust, Inc.

 

17140 Bernardo Center Drive, Suite 222

 

San Diego, CA 92128

 

Re:                                1885 33 rd  Street, 1825 33 rd  Street, 1865 33 rd  Street and 3200 Walnut Street (the “ Premises ”) in Boulder, Colorado (the “ Property ”)

 

The undersigned tenant (“ Tenant ”) hereby certifies to you as follows:

1.             Tenant is a tenant at the Property under a lease (the “ Lease ”) for the Premises dated as of [              ], 20[    ]. The Lease has not been cancelled, modified, assigned, extended or amended [except as follows: [              ]], and there are no other agreements, written or oral, affecting or relating to Tenant’s lease of the Premises or any other space at the Property.  The lease term expires on [              ], 20[    ].

2.             Tenant took possession of the Premises, currently consisting of [              ] square feet, on [              ], 20[    ], and commenced to pay rent on [              ], 20[    ].  Tenant has full possession of the Premises, has not assigned the Lease or sublet any part of the Premises, and does not hold the Premises under an assignment or sublease[, except as follows:  [              ]].

3.             All base rent, rent escalations and additional rent under the Lease have been paid through [              ], 20[    ]. There is no prepaid rent[, except $[              ]][, and the amount of security deposit is $[              ] [in cash][in the form of a letter of credit]].  Tenant currently has no right to any future rent abatement under the Lease.

4.             Base rent is currently payable in the amount of $[              ] per month.

5.             Tenant is currently paying estimated payments of additional rent of $[              ] per month on account of real estate taxes, insurance, management fees and common area maintenance expenses.

6.             All work to be performed for Tenant under the Lease has been performed as required under the Lease and has been accepted by Tenant[, except [              ]], and all allowances to be paid to Tenant, including allowances for tenant improvements, moving expenses or other items, have been paid.

7.             The Lease is in full force and effect, free from default and free from any event that could become a default under the Lease, and Tenant has no claims against the landlord or offsets or defenses against rent, and there are no disputes with the landlord. Tenant has received no notice of prior sale, transfer, assignment, hypothecation or pledge of the Lease or of the rents payable thereunder[, except [              ]].

8.             [Tenant has the following expansion rights or options for the Property: [              ].][Tenant has no rights or options to purchase the Property.]

9.             To Tenant’s knowledge, no hazardous wastes have been generated, treated, stored or disposed of by or on behalf of the Tenant in, on or around the Premises in violation of any environmental laws.

10.           The undersigned has executed this Estoppel Certificate with the knowledge and understanding that BMR-3200 Walnut Street LLC or its assignee is acquiring the Property in reliance on this certificate and that the undersigned shall be bound by this certificate.  The statements contained herein may be relied upon by BMR-3200 Walnut Street LLC, BioMed




Realty, L.P., BioMed Realty Trust, Inc., and any mortgagee of the Property and their respective successors and assigns.

 

Any capitalized terms not defined herein shall have the respective meanings given in the Lease.

Dated this [        ] day of [              ], 20[    ].

[              ],

a [              ]

By:

 

 

Name:

 

 

Title:

 

 

 




EXHIBIT F

 

NONFUNCTIONAL EQUIPMENT

 

BUILDING ONE

#

 

UNIT ID

 

STATUS

1.

 

HOUSE VACUUM SYSTEM

 

NON-FUNCTIONING

2.

 

VFD FOR EF 10

 

NON-FUNCTIONING

 

BUILDING TWO

#

 

UNIT ID

 

STATUS

1.

 

STERLING MUA’S 1-12

 

NON-FUNCTIONING

2.

 

AHU 2

 

NON-FUNCTIONING

3.

 

STEAM BOILER

 

NON-FUNCTIONING

4.

 

HALL-FAN POWERED BOXES (21)

 

NON-FUNCTIONING

5.

 

50 HP AIR COMPRESSOR

 

NON-FUNCTIONING

6.

 

SEVERAL EXHAUST FANS (13)

 

NON-FUNCTIONING

7.

 

CLEAN STEAM BOILER

 

NON-FUNCTIONING

8.

 

AUTO CLAVES

 

NON-FUNCTIONING

9.

 

SEVERAL SINKS (3)

 

NON-FUNCTIONING

10.

 

COOLER ROOM 34

 

NON-FUNCTIONING

11.

 

COOLER ROOM 238

 

NON-FUNCTIONING

12.

 

COOLER ROOM 40

 

NON-FUNCTIONING

13.

 

SEVERAL STEAM POWERED PUMPS (5)

 

NON-FUNCTIONING

14.

 

DI WATER SYSTEM

 

NON-FUNCTIONING

15.

 

CHILLER ON ROOF

 

NON-FUNCTIONING

16.

 

MEULLER PYROPURE

 

NON-FUNCTIONING

17.

 

DI WATER TANK 1

 

NON-FUNCTIONING

18.

 

DI WATER TANK 2

 

NON-FUNCTIONING

19.

 

ANSCO 3043

 

NON-FUNCTIONING

20.

 

ANSCO 3023

 

NON-FUNCTIONING

21.

 

VWR 1690 GLASS WASH DRYER

 

NON-FUNCTIONING

22.

 

STERIS RELIANSCE 500 WASHER

 

NON-FUNCTIONING

23.

 

HOUSE VACUUM SYSTEM

 

NON-FUNCTIONING

 

BUILDING THREE

#

 

UNIT ID

 

STATUS

1.

 

SMALL CLEAVER BROOKS BOILER

 

NON-FUNCTIONING

2.

 

EXHAUST FAN 21

 

NON-FUNCTIONING

3.

 

VACUUM PUMP

 

NON-FUNCTIONING

4.

 

CLEAN STEAM BOILER

 

NON-FUNCTIONING

5.

 

DI WATER SYSTEM

 

NON-FUNCTIONING

6.

 

DI-R07

 

NON-FUNCTIONING

7.

 

WALK IN COOLER #47160

 

NON-FUNCTIONING

8.

 

HEINIOKE WASHING MACHINE

 

NON-FUNCTIONING

9.

 

AMSCO 3024 AUTO CLAVE

 

NON-FUNCTIONING

 




 

BUILDING FOUR

 

#

 

UNIT ID

 

STATUS

1.

 

LIQUID NITROGEN TANK

 

NON-FUNCTIONING

2.

 

EF 3

 

WORKS, NON-FUNCTIONING

 



Exhibit 10.2

 

EXECUTION VERSION

 

LEASE

 

 

by and between

 

 

BMR-Trade Centre Avenue LLC,

a Delaware limited liability company

 

 

and

 

 

Array BioPharma Inc.,

a Delaware corporation




LEASE

THIS LEASE (this “ Lease ”) is entered into as of this 9 th  day of August, 2006, by and between BMR-Trade Centre Avenue LLC, a Delaware limited liability company (“ Landlord ”), and Array BioPharma Inc., a Delaware corporation (“ Tenant ”).

RECITALS

WHEREAS, Landlord owns certain real property (the “ Property ”) and the building improvements thereon located at 2600 and 2620 Trade Centre Avenue, Longmont, Colorado, including the buildings located thereon (the “ Building ”) in which the Premises (as defined below) are located; and

WHEREAS, Landlord wishes to lease to Tenant, and Tenant desires to lease from Landlord, the Premises (as defined below) pursuant to the terms and conditions of this Lease, as detailed below.

AGREEMENT

NOW, THEREFORE, Landlord and Tenant, in consideration of the mutual promises contained herein and for other good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, and intending to be legally bound, agree as follows:

1.              Lease of Premises . Landlord hereby leases to Tenant, and Tenant hereby leases from Landlord, the Premises, as shown on Exhibit A attached hereto.  The Property and all landscaping, parking facilities and other improvements and appurtenances related thereto, including, without limitation, the Building, are hereinafter collectively referred to as the “ Premises .”

2.              Basic Lease Provisions . For convenience of the parties, certain basic provisions of this Lease are set forth herein. The provisions set forth herein are subject to the remaining terms and conditions of this Lease and are to be interpreted in light of such remaining terms and conditions.

2.1.           This Lease shall take effect upon the date of execution and delivery hereof by all parties hereto and, except as specifically otherwise provided within this Lease, each of the provisions hereof shall be binding upon and inure to the benefit of Landlord and Tenant from the date of execution and delivery hereof by all parties hereto.

2.2.           Rentable Area of the Premises:  78,023 sq. ft., subject to adjustment pursuant to the terms hereof

2.3.           Initial Monthly Rental Installments of Basic Annual Rent:  78,023 s.f. x $27.79 per s.f. / 12 = $180,688.26, subject to adjustment pursuant to the terms hereof

2.4.           Initial Basic Annual Rent: 78,023 s.f. x $27.79 per s.f. = $2,168,259.17, subject to adjustment pursuant to the terms hereof

2.5.           Term Commencement Date:  August 9, 2006

2.6.           Term Expiration Date:  August 9, 2016

2.7.           Security Deposit: $2,168,259.17

2.8.           Permitted Use:  General office and laboratory use in conformity with Applicable Laws (as defined below)

2.9.           Address for Rent Payment: BMR-Trade Centre Avenue LLC, 17190 Bernardo Center Drive, Suite 222, San Diego, California 92128, Attn: Karen Sztraicher.

2.10.         Address for Notices to Landlord: BMR-Trade Centre Avenue LLC, c/o BioMed Realty, L.P., 17190 Bernardo Center Drive, Suite 222, San Diego, California 92128, Attn: General Counsel/Finance Department.

1




2.11.         Address for Notices to Tenant: Array BioPharma Inc., 3200 Walnut Street, Boulder Colorado 80301, Attn: John Moore.

2.12.         The following Exhibits are attached hereto and incorporated herein by reference:

Exhibit A

Premises

Exhibit B

Acknowledgement of Term Commencement Date and Term Expiration Date

Exhibit C

Tenant’s Personal Property

Exhibit D

Rules and Regulations

Exhibit E

Form of Estoppel Certificate

Exhibit F

Nonfunctional Equipment

 

3.              Term .

3.1.           This Lease shall take effect upon the date of execution and delivery hereof by all parties hereto and, except as specifically otherwise provided within this Lease, each of the provisions hereof shall be binding upon and inure to the benefit of Landlord and Tenant from the date of execution and delivery hereof by all parties hereto.

3.2.           The actual term of this Lease (the “ Term ”) shall be that period from the Term Commencement Date through the Term Expiration Date, subject to earlier termination of this Lease as provided herein.

4.              Tenant Improvements .

4.1            Prior to entering upon the Premises, Tenant shall furnish to Landlord evidence satisfactory to Landlord that insurance coverages required of Tenant under the provisions of Section 20 are in effect, and such entry shall be subject to all the terms and conditions of this Lease other than the payment of Basic Annual Rent or Additional Rent (as defined below).

4.2            Tenant hereby acknowledges that Tenant knows the condition of the Premises and agrees to accept the same in “as is” condition.  It is understood and agreed that Landlord is not obligated to install any equipment, or make any repairs, improvements or alterations to the Premises.  Tenant shall have the right to make appropriate repairs and improvements to the Premises in accordance with the terms and conditions of Section 17 hereof (“ Tenant Improvements ”). Tenant shall be responsible for performing and completing the Tenant Improvements.  Upon the Term Commencement Date, Landlord shall pay to Tenant a tenant improvement allowance (“ Tenant Improvement Allowance ”) in the amount of $300,000 to cover the reasonable cost of constructing Tenant’s Tenant Improvements to the Premises and related fees and expenses, including, but not limited to, labor, materials, space planning, construction documents, permits, fees, construction management, etc, as such costs may be demonstrated by Tenant to the reasonable satisfaction of Landlord.  All improvements shall be subject to the requirements of the Lease with respect to alternations and to building standards for finishes and materials.  Any direct or indirect Tenant Improvement costs that exceed the Tenant Improvement Allowance shall be paid by Tenant.  Tenant shall pay to Landlord as Additional Rent the Tenant Improvement Allowance, together with interest thereon at the rate of ten and one-half percent (10.5%) per annum, which amount shall be amortized over the original Term of the Lease and shall be due and payable in equal monthly installments of Four Thousand Twelve and 94/100 Dollars ($4,012.94) per month when Basic Monthly Rent is due and payable under the Lease

4.3            Landlord and Tenant shall mutually agree upon the selection of the architect, engineer, general contractor and major subcontractors, and Landlord and Tenant shall each participate in the review of the competitive bid process.

5.              Rent .

5.1.           Tenant shall pay to Landlord as Basic Annual Rent for the Premises, commencing on the Term Commencement Date, the sum set forth in Section 2.4 , subject to the rental adjustments provided in Section 6 hereof. Basic Annual Rent shall be paid in equal monthly installments as set forth in Section 2.3 (“ Basic Monthly Rent ”), subject to the rental adjustments provided in Section 6 hereof, each in advance on the first day of each and every calendar month during the Term.

2




5.2.           In addition to Basic Annual Rent, Tenant shall pay to Landlord as additional rent (“ Additional Rent ”) at times hereinafter specified in this Lease (a) amounts related to Insurance Costs and Taxes (each as defined below) and (b) any other amounts that Tenant assumes or agrees to pay under the provisions of this Lease that are owed to Landlord, including, without limitation, any and all other sums that may become due by reason of any default of Tenant or failure on Tenant’s part to comply with the agreements, terms, covenants and conditions of this Lease to be performed by Tenant, after notice and the lapse of any applicable cure periods.

5.3.           Basic Annual Rent and Additional Rent shall together be denominated “ Rent .” Rent shall be paid to Landlord, without abatement, deduction or offset, in lawful money of the United States of America at the office of Landlord as set forth in Section 2.9 or to such other person in the United States or at such other place as Landlord may from time designate in writing.  In the event the Term commences or ends on a day other than the first day of a calendar month, then the Rent for such fraction of a month shall be prorated for such period on the basis of a thirty (30) day month and shall be paid at the then-current rate for such fractional month.

6.              Rent Adjustments . The Basic Annual Rent shall be subject to an annual upward adjustment of two percent (2%) of the then-current Basic Annual Rent.  The first such adjustment shall become effective commencing August 1, 2007, and subsequent adjustments shall become effective on every successive August 1 for so long as this Lease continues in effect.

7.              Taxes .

7.1.           Commencing with the Term Commencement Date and continuing for each calendar year or, at Landlord’s option, tax year (each such “tax year” being a period of twelve (12) consecutive calendar months for which the applicable taxing authority levies or assesses Taxes), for the balance of the Term, Tenant shall pay to Landlord the amount of all Taxes levied and assessed for any such year upon the Premises during the Term.  “ Taxes ” shall mean all government impositions including, without limitation, property tax costs consisting of real and personal property taxes and assessments (including amounts due under any improvement bond upon the Premises or any portion thereof, including the parcel or parcels of real property upon which the Building is located or assessments levied in lieu thereof) imposed by any federal, state, regional, local or municipal governmental authority, agency or subdivision (each, a “ Governmental Authority ”) on the Premises or improvements thereon, any tax on or measured by gross rentals received from the rental of space in the Building, or tax based on the square footage of the Premises or the Building as well as any parking charges, utilities surcharges, or any other costs levied, assessed or imposed by, or at the direction of, or resulting from statutes or regulations, or interpretations thereof, promulgated by any Governmental Authority in connection with the use or occupancy of the Premises or the parking facilities serving the Premises; any tax on this transaction or this Lease; provided , however, that “ Taxes ” shall in no event include any franchise or income tax or any tax based on net rentals received from the rental of space in the Building.  Any amount paid by Tenant for any partial year of the Term shall be prorated on the basis of the number of days of such partial year.  Payment shall be made in the following manner: Tenant shall pay to Landlord the amounts owed under this Section 7 within thirty (30) days after Landlord gives notice to Tenant of the amount of such Taxes payable by Tenant (or not less than twenty (20) days prior to delinquency, whichever is later).  Landlord also shall provide Tenant with a copy of the applicable tax bill or tax statement from the relevant taxing authority. Notwithstanding the foregoing, if Applicable Laws allow any such Taxes to be paid in installments, then Tenant may make such payments to Landlord in installments, provided that each such installment shall be payable to Landlord not less than twenty (20) days prior to the date upon which payment of the applicable installment to the taxing authority becomes delinquent. In addition to any other amounts due from Tenant to Landlord, if Tenant fails to pay Taxes to Landlord as herein required, Tenant shall pay to Landlord the amount of any interest, penalties or late charges imposed for late payment.  “ Applicable Laws ” means all laws, codes, ordinances, rules and regulations of Governmental Authorities having jurisdiction over the Premises or any portion thereof, or over Landlord or Tenant.

(a)            If the Premises are separately assessed, Tenant shall have the right, by appropriate proceedings, to protest or contest in good faith any assessment or reassessment of Taxes, any special assessment, or the validity of any Taxes or of any change in assessment or tax rate; provided , however, that prior to any such challenge Tenant must either (a) pay the Taxes alleged to be due in their entirety and seek a refund from the appropriate authority or (b) post a

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bond in an amount sufficient to ensure full payment of the Taxes, including any potential interest, late charges and penalties.  Upon a final determination with respect to any such contest or protest, Tenant shall promptly pay to the appropriate Governmental Authority all sums found to be due with respect thereto. In any such protest or contest, Tenant may act in its own name, and at the request of Tenant, Landlord shall cooperate with Tenant in any way Tenant may reasonably require in connection with such contest or protest, including signing such documents as Tenant reasonably shall request, provided that such cooperation shall be at no expense to Landlord and shall not require Landlord to attend any appeal or other hearing.  Any such contest or protest shall be at Tenant’s sole expense, and if any penalties, interest or late charges become payable with respect to the Taxes as a result of such contest or protest, Tenant shall pay the same.

(b)            If Tenant obtains a refund as the result of Tenant’s protest or contest, and subject to Tenant’s obligation to pay Landlord’s costs (if any) associated therewith, Tenant shall be entitled to such refund to the extent it relates to the Premises during the Term.

7.2.           Tenant shall be solely responsible for the payment of any and all taxes levied upon personal property and trade fixtures located upon the Premises, and shall pay the same at least ten (10) days prior to delinquency.

7.3.           If, at any time during the Term under the laws of any Governmental Authority, a tax or excise on rent or any other tax howsoever described is levied or assessed by any such political body against Landlord on account of rentals payable to Landlord hereunder, such tax or excise shall be considered “ Taxes ” for the purposes of this Section 7 , although any amount assessed against Landlord as state or federal income tax shall not be deemed “ Taxes .”

7.4.           To the extent Landlord is required by a lender, Tenant shall timely pay all tax and insurance impound payments due on the Premises.

8.              Rentable Area .

8.1.           The term “ Rentable Area ” as set forth in Section 2 , and as may otherwise be referenced within this Lease.

8.2.           The “ Rentable Area ” of the Building is generally determined by making separate calculations of Rentable Area applicable to each floor within the Building and totaling the Rentable Area of all floors within the Building. The Rentable Area of a floor is computed by measuring to the outside finished surface of the permanent outer Building walls.  The full area calculated as previously set forth is included as Rentable Area, without deduction for columns and projections or vertical penetrations, including stairs, elevator shafts, flues, pipe shafts, vertical ducts and the like, as well as such items’ enclosing walls.

9.              Security Deposit .

9.1.           Tenant has deposited with Landlord the sum set forth in Section 2.7 (payable in cash or, in the form of a letter of credit reasonably acceptable to Landlord) (the “ Security Deposit ”), which Security Deposit shall be held by Landlord as security for the faithful performance by Tenant of all of the terms, covenants and conditions of this Lease to be kept and performed by Tenant during the period commencing on the Commencement Date and ending upon the expiration or termination of this Lease.  If Tenant defaults with respect to any provision of this Lease, including, but not limited to, any provision relating to the payment of Rent, then Landlord may (but shall not be required to) use, apply or retain all or any part of the Security Deposit for the payment of any Rent or any other sum in default, or to compensate Landlord for any other loss or damage that Landlord may suffer by reason of Tenant’s default.  If any portion of the Security Deposit is so used or applied, then Tenant shall, within ten (10) days following demand therefor, deposit cash with Landlord in an amount sufficient to restore the Security Deposit to its original amount, or replenish the letter of credit to the amount required hereunder, and Tenant’s failure to do so shall be a material breach of this Lease. Landlord shall not be required to keep this Security Deposit separate from its general fund, and Tenant shall not be entitled to interest on the Security Deposit.

9.2.           In lieu of depositing cash as the Security Deposit, Tenant shall have the right to deliver to Landlord an unconditional, irrevocable, standby letter of credit in the amount of the

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cash Security Deposit otherwise required hereunder, which letter of credit shall (i) be in a form reasonably acceptable to Landlord, (ii) be issued by a financial institution selected by Tenant and reasonably acceptable to Landlord, (iii) be for the benefit of Landlord, but shall be transferable at Tenant’s sole cost and expense by Landlord to any subsequent purchaser or encumbrancer of the Building, and (iv) be payable by draft sight in a location reasonably acceptable to Landlord upon presentation of a certification signed by an officer of Landlord which states that an event of Default has occurred under this Lease, and (v) be payable in the event such letter of credit is not renewed on or before the date which is thirty (30) days prior to its expiration.  Any amounts of cash drawn on a letter of credit Security Deposit will thereafter be treated as a cash Security Deposit hereunder; provided that Tenant shall be permitted to restore the original balance of the letter of credit and have the corresponding cash Security Deposit returned to Tenant.

9.3.           In the event of bankruptcy or other debtor-creditor proceedings against Tenant, the Security Deposit shall be deemed to be applied first to the payment of Rent and other charges due Landlord for all periods prior to the filing of such proceedings.

9.4.           Landlord may deliver to any purchaser of Landlord’s interest in the Premises the funds deposited hereunder by Tenant, and thereupon Landlord shall be discharged from any further liability with respect to such deposit.  This provision shall also apply to any subsequent transfers.

9.5.           If Tenant shall fully and faithfully perform every provision of this Lease to be performed by it, then the Security Deposit, or any balance thereof, shall be returned to Tenant (or, at Landlord’s option, to the last assignee of Tenant’s interest hereunder) within thirty (30) days after the expiration or earlier termination of this Lease.

10.           Use .

10.1.         Tenant shall use the Premises for the purpose set forth in Section 2.8 , and shall not use the Premises, or permit or suffer the Premises to be used, for any other purpose without Landlord’s prior written consent, which consent Landlord may withhold in its sole and absolute discretion.

10.2.         Tenant shall not use or occupy the Premises in violation of Applicable Laws; zoning ordinances; or the certificate of occupancy issued for the Building, and shall, upon five (5) days’ written notice from Landlord, discontinue any use of the Premises that is declared or claimed by any Governmental Authority having jurisdiction to be a violation of any of the above, or that in Landlord’s reasonable opinion violates any of the above.  Tenant shall comply with any direction of any Governmental Authority having jurisdiction that shall, by reason of the nature of Tenant’s use or occupancy of the Premises, impose any duty upon Tenant or Landlord with respect to the Premises or with respect to the use or occupation thereof.

10.3.         Tenant shall not knowingly do or permit to be done anything that will invalidate or increase the cost of any fire, environmental, extended coverage or any other insurance policy covering the Premises, and shall comply with all rules, orders, regulations and requirements of the insurers of the Premises, and Tenant shall promptly, upon demand, reimburse Landlord for any additional premium charged for such policy by reason of Tenant’s failure to comply with the provisions of this Section.

10.4.         No awnings or other projections shall be attached to any outside wall of the Building.

10.5.         No additional sign, advertisement or notice shall be exhibited, painted or affixed by Tenant on any part of the exterior of the Building or on the Property without Landlord’s prior written consent, which will not be unreasonably withheld.  By executing this Lease, Landlord hereby approves the signage currently existing on the Premises.

10.6.         Tenant shall not use or allow the Premises to be used for unlawful purposes, nor shall Tenant knowingly cause, maintain or permit any nuisance or waste in, on or about the Premises.

10.7.         Notwithstanding any other provision herein to the contrary, Tenant shall be responsible for all liabilities, costs and expenses arising out of or in connection with the

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compliance of the Premises with the Americans with Disabilities Act, 42 U.S.C. § 12101, et seq. (together with regulations promulgated pursuant thereto, the “ ADA ”), and Tenant shall indemnify, defend and hold harmless Landlord from and against any loss, cost, liability or expense (including reasonable attorneys’ fees and disbursements) arising out of any failure of the Premises to comply with the ADA.  The provisions of this Section 10.7 shall survive the expiration or earlier termination of this Lease.

11.            Brokers .

11.1.         Tenant represents and warrants that it has had no dealings with any real estate broker or agent in connection with the negotiation of this Lease and that it knows of no real estate broker or agent that is or might be entitled to a commission in connection with this Lease.

11.2.         Tenant represents and warrants that no broker or agent has made any representation or warranty relied upon by Tenant in Tenant’s decision to enter into this Lease, other than as contained in this Lease.

11.3.         Tenant acknowledges and agrees that the employment of brokers by Landlord is for the purpose of solicitation of offers of leases from prospective tenants and that no authority is granted to any broker to furnish any representation (written or oral) or warranty from Landlord unless expressly contained within this Lease.  Landlord is executing this Lease in reliance upon Tenant’s representations and warranties contained within Sections 11.1 and 11.2 .

12.            Holding Over .

12.1.         If, with Landlord’s prior written consent, Tenant holds possession of all or any part of the Premises after the Term, Tenant shall become a tenant from month to month after the expiration or earlier termination of the Term, and in such case Tenant shall continue to pay (a) the Basic Annual Rent in accordance with Section 5 , as adjusted in accordance with Section 6 , and (b) any amounts for which Tenant would otherwise be liable under this Lease if the Lease were still in effect, including, without limitation, payments for Taxes and insurance.  Any such month-to-month tenancy shall be subject to every other term, covenant and agreement contained herein.

12.2.         Notwithstanding the foregoing, if Tenant remains in possession of the Premises after the expiration or earlier termination of the Term without Landlord’s prior written consent, Tenant shall become a tenant at sufferance subject to the terms and conditions of this Lease, except that the Basic Monthly Rent shall be equal to one hundred fifty percent (150%) of the Rent in effect during the last thirty (30) days of the Term.

12.3.         Acceptance by Landlord of Rent after the expiration or earlier termination of the Term shall not result in an extension, renewal or reinstatement of this Lease.

12.4.         The foregoing provisions of this Section 12 are in addition to and do not affect Landlord’s right of reentry or any other rights of Landlord hereunder or as otherwise provided by Applicable Laws.

13.            Property Management Fee .  Tenant shall pay to Landlord on the first day of each calendar month of the Term, as Additional Rent, the “ Property Management Fee ,” which shall equal $1,355.00 per month.

14.            Condition of Premises .  Tenant acknowledges that neither Landlord nor any agent of Landlord has made any representation or warranty with respect to the condition of the Premises, or with respect to the suitability of the Premises for the conduct of Tenant’s business.  Tenant’s taking of possession of the Premises shall, except as otherwise agreed to in writing by Landlord and Tenant, conclusively establish that Tenant accepts the Premises “as is.”

15.            Utilities and Services .

15.1.         Tenant shall, at its sole cost and expense, promptly and properly observe and comply with (including in the making by Tenant of any alterations to the Premises) all present and future orders, regulations, directions, rules, laws, ordinances, and requirements of all

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Governmental Authorities arising from the use or occupancy of, or applicable to, the Premises or any portion thereof.

15.2.         Within sixty (60) days after the Term Commencement Date, and within sixty (60) days after the beginning of each calendar year during the Term, Landlord shall give Tenant a written estimate for such calendar year of insurance provided by Landlord (“ Insurance Costs ”). Tenant shall pay such estimated amount to Landlord in advance in equal monthly installments. Within ninety (90) days after the end of each calendar year, Landlord shall furnish to Tenant a statement showing in reasonable detail the costs incurred by Landlord for the operation and maintenance of the Premises during such year (the “ Annual Statement ”), and Tenant shall pay to Landlord the costs incurred in excess of the payments previously made by Tenant within ten (10) days of receipt of the Annual Statement.  In the event that the payments previously made by Tenant for the operation and maintenance of the Premises exceed Tenant’s obligation, such excess amount shall be credited by Landlord to the Rent or other charges next due and owing, provided that, if the Term has expired, Landlord shall remit such excess amount to Tenant.

15.3.         Tenant shall make all arrangements for and pay for all water, sewer, gas, heat, light, power, telephone service and any other service or utility Tenant required at the Premises. Landlord shall not be liable for, nor shall any eviction of Tenant result from, the failure to furnish any utility or service, whether or not such failure is caused by accident; breakage; repair; strike, lockout or other labor disturbance or labor dispute of any character; governmental regulation, moratorium or other governmental action (collectively, “ Force Majeure ”).  In the event of such failure, Tenant shall not be entitled to termination of this Lease, any abatement or reduction of Rent, or relief from the operation of any covenant or agreement of this Lease. Tenant shall pay for, prior to delinquency of payment therefor, any utilities and services that may be furnished to the Premises during or, if Tenant occupies the Premises after the expiration or earlier termination of the Term, after the Term.

16.            Alterations .

16.1.         Tenant shall make no alterations, additions or improvements in or to the Premises that cost in excess of $100,000 without Landlord’s prior written approval, which approval Landlord shall not unreasonably withhold; provided , however , that in the event any proposed alteration, addition or improvement affects (a) any structural portions of the Building, including exterior walls, roof, foundation or core of the Building, (b) the exterior of the Building or (c) any Building systems, including elevator, plumbing, air conditioning, heating, electrical, security, life safety and power, then Landlord may withhold its approval with respect thereto in its sole and absolute discretion. In seeking Landlord’s approval, Tenant shall provide Landlord, at least fourteen (14) days in advance of any proposed construction, with plans, specifications, bid proposals, work contracts, requests for laydown areas and such other information concerning the nature and cost of the alterations as Landlord may reasonably request.

16.2.         Tenant shall not construct or permit to be constructed partitions or other obstructions that might interfere with free access to mechanical installation or service facilities of the Building, or interfere with the moving of Landlord’s equipment to or from the enclosures containing such installations or facilities.

16.3.         Tenant shall accomplish any work performed on the Premises in such a manner as to permit any fire sprinkler system and fire water supply lines to remain fully operable at all times.

16.4.         Tenant covenants and agrees that all work done by Tenant or Tenant’s contractors shall be performed in full compliance with Applicable Laws.  Tenant shall provide Landlord with complete “as-built” drawing print sets and electronic CADD files on disc showing any changes in the Premises for which Landlord’s approval is required pursuant to Section 16.1 .

16.5.         Before commencing any work for which Landlord’s approval is required pursuant to Section 16.1 , Tenant shall give Landlord at least fourteen (14) days’ prior written notice of the proposed commencement of such work and shall, if required by Landlord, secure, at Tenant’s own cost and expense, a completion and lien indemnity bond satisfactory to Landlord for said work.

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16.6.         All alterations, attached equipment, fixtures, additions and improvements, subject to Section 17.6 , attached to or built into the Premises, made by either of the Parties, including, without limitation, all flooring and wall coverings, built-in cabinet work and paneling, sinks and related plumbing fixtures, exterior venting fume hoods and walk-in freezers and refrigerators, ductwork, conduits, electrical panels and circuits, shall, unless, prior to such construction or installation, Landlord elects otherwise, become the property of Landlord upon the expiration or earlier termination of the Term, and shall remain upon and be surrendered with the Premises as a part thereof.

16.7.         Tenant shall repair any damage to the Premises caused by Tenant’s removal of any property from the Premises.  During any such restoration period, Tenant shall pay Rent to Landlord as provided herein as if said space were otherwise occupied by Tenant.

16.8.         Except as to those items listed on Exhibit C attached hereto, all fixtures (except for Tenant’s trade fixtures), built-in furniture and cabinets installed in and upon the Premises shall be and remain the property of Landlord and shall not be moved by Tenant at any time during the Term.  If Tenant shall fail to remove any of its effects from the Premises prior to termination of this Lease, then Landlord may, at its option, remove the same in any manner that Landlord shall choose and store said effects without liability to Tenant for loss thereof or damage thereto, and Tenant shall pay Landlord, upon demand, any costs and expenses incurred due to such removal and storage or Landlord may, at its sole option and without notice to Tenant, sell such property or any portion thereof at private sale and without legal process for such price as Landlord may obtain and apply the proceeds of such sale against any (a) amounts due by Tenant to Landlord under this Lease and (b) any expenses incident to the removal, storage and sale of said personal property.

16.9.         Notwithstanding any other provision of this Section 16 to the contrary, in no event shall Tenant remove any improvement from the Premises as to which Landlord contributed payment without Landlord’s prior written consent, which consent Landlord may withhold in its sole and absolute discretion.

16.10.       Tenant shall reimburse Landlord for any extra expenses incurred by Landlord by reason of faulty work done by Tenant or its contractors, or by reason of delays caused by such work, or by reason of inadequate clean-up.

16.11.       After final completion of the Tenant Improvements (or any other alterations, improvement or additions performed by Tenant with respect to the Premises) for which Landlord approval is required pursuant to Section 16.1 , Tenant shall submit to Landlord documentation showing the amounts expended by Tenant with respect to such Tenant Improvements (or any other alterations, improvement or additions performed by Tenant with respect to the Premises).

17.            Repairs and Maintenance .

17.1.         Tenant, at its sole cost and expense, shall maintain and keep the Premises, all improvements thereon, and all appurtenances thereto, including but not limited to sidewalks, parking areas, curbs, roads, driveways, lighting standards, landscaping, sewers, water, gas and electrical distribution systems and facilities, drainage facilities, and all signs, both illuminated and non-illuminated that are now or hereafter on the Premises, in good condition and in a manner consistent with the Permitted Use. Tenant shall make all repairs, replacements and improvements, including, without limitation, all structural, roof, HVAC, plumbing and electrical repairs, replacements and improvements required, and shall keep the same free and clear from all rubbish and debris. All repairs made by Tenant shall be at least equal in quality to the original work, and shall be made only by a licensed bondable contractor.  Tenant shall not take or omit to take any action, the taking or omission of which shall cause waste, damage or injury to the Premises.  Tenant shall indemnify, defend (by legal counsel acceptable to Landlord) and hold harmless Landlord from and against any and all Claims (as defined below) arising out of the failure of Tenant or Tenant’s Agents to perform the covenants contained in this paragraph. “ Tenant’s Agents ” shall be defined to include Tenant’s officers, employees, agents, contractors, invitees, customers and subcontractors.

17.2.         Tenant shall maintain the lines designating the parking spaces in good condition and paint the same as often as may be necessary, so that they are easily discernable at all times; resurface the parking areas as necessary to maintain them in good condition; paint any exterior

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portions of the Building as necessary to maintain them in good condition; maintain the roof and landscaping in good condition; maintain sightly screens, barricades or enclosures around any waste or storage areas; and take all reasonable precautions to insure that the drainage facilities of the roof are not clogged and are in good and operable condition at all times.

17.3.         There shall be no abatement of Rent and no liability of Landlord by reason of any injury to or interference with Tenant’s business arising from the making of any repairs, alterations or improvements in or to any portion of the Premises, or in or to improvements, fixtures, equipment and personal property therein; provided that Landlord shall not unreasonably interfere with Tenant’s use or quiet enjoyment of the Premises.

17.4.         Except as provided in Section 21 (Damage or Destruction), during the Term, Landlord shall not be required to maintain or make any repairs or replacements of any nature or description whatsoever to the Premises.  Tenant hereby expressly waives the right to make repairs at the expense of Landlord as provided for in any Applicable Laws in effect at the time of execution of this Lease, or in any other Applicable Laws that may hereafter be enacted, and waives its rights under Applicable Laws relating to a landlord’s duty to maintain its premises in a tenantable condition. Notwithstanding the foregoing, if Tenant shall fail, after reasonable notice, to maintain or to commence and thereafter to proceed with diligence to make any repair required of it pursuant to the terms of this Lease, Landlord, without being under any obligation to do so and without thereby waiving such default by Tenant, may so maintain or make such repair and may charge Tenant for the costs thereof.  Any expense reasonably incurred by Landlord in connection with the making of such repairs may be billed by Landlord to Tenant monthly or, at Landlord’s option, immediately, and shall be due and payable within ten (10) days after such billing or, at Landlord’s option, may be deducted from the Security Deposit.

17.5.         Landlord and Landlord’s agents shall have the right to enter upon the Premises or any portion thereof for the purposes of performing any repairs or maintenance Landlord is permitted to make pursuant to this Lease, and of ascertaining the condition of the Premises or whether Tenant is observing and performing Tenant’s obligations hereunder, all without unreasonable interference from Tenant or Tenant’s Agents.  Except for emergency maintenance or repairs, the right of entry contained in this paragraph shall be exercisable at reasonable times, at reasonable hours and on reasonable notice.

17.6.         Tenant shall, upon the expiration or sooner termination of the Term, surrender the Premises to Landlord in as good of a condition as when received, ordinary wear and tear excepted. The parties acknowledge the nonfunctional status of certain equipment listed on Exhibit F attached hereto (the “ Nonfunctional Equipment ”). Landlord shall have no obligation to alter, remodel, improve, repair, decorate or paint the Premises or any part thereof.

17.7.         This Section 17 relates to repairs and maintenance arising in the ordinary course of operation of the Premises and any related facilities.  In the event of fire, earthquake, flood, vandalism, war or similar cause of damage or destruction, Section 21 shall apply in lieu of this Section 17 .

18.            Liens .

18.1.         Subject to the immediately succeeding sentence, Tenant shall keep the Premises free from any liens arising out of work performed, materials furnished or obligations incurred by Tenant. Tenant further covenants and agrees that any mechanic’s lien filed against the Premises for work claimed to have been done for Tenant, or materials claimed to have been furnished to Tenant, shall be discharged or bonded by Tenant within ten (10) days after Tenant is given notice thereof, at Tenant’s sole cost and expense.

18.2.         Should Tenant fail to discharge or bond against any lien of the nature described in Section 18.1 , Landlord may, at Landlord’s election, pay such claim or post a bond or otherwise provide security to eliminate the lien as a claim against title, and Tenant shall immediately reimburse Landlord for the costs thereof as Additional Rent.

18.3.         In the event that Tenant leases or finances the acquisition of office equipment, furnishings or other personal property of a removable nature utilized by Tenant in the operation of Tenant’s business, Tenant warrants that any Uniform Commercial Code financing statement executed by Tenant shall, upon its face or by exhibit thereto, indicate that such financing

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statement is applicable only to removable personal property of Tenant located within the Premises.  In no event shall the address of the Premises be furnished on a financing statement without qualifying language as to applicability of the lien only to removable personal property located in an identified suite leased by Tenant.  Should any holder of a financing statement executed by Tenant record or place of record a financing statement that appears to constitute a lien against any interest of Landlord or against equipment that may be located other than within an identified suite leased by Tenant, Tenant shall, within ten (10) days after filing such financing statement, cause (a) a copy of the lender security agreement or other documents to which the financing statement pertains to be furnished to Landlord to facilitate Landlord’s ability to demonstrate that the lien of such financing statement is not applicable to Landlord’s interest and (b) Tenant’s lender to amend such financing statement and any other documents of record to clarify that any liens imposed thereby are not applicable to any interest of Landlord in the Premises.

19.            Indemnification and Exculpation .

19.1.         Tenant agrees to indemnify, defend and save  Landlord harmless from and against any and all demands, claims, liabilities, losses, costs, expenses, actions, causes of action, damages or judgments, and all reasonable expenses (including, without limitation, reasonable attorneys’ fees, charges and disbursements) incurred in investigating or resisting the same (collectively, “ Claims ”) arising from injury or death to any person or injury to any property occurring within or about the Premises arising directly or indirectly out of Tenant’s or Tenant’s employees’, agents’ or guests’ use or occupancy of the Premises or a breach or default by Tenant in the performance of any of its obligations hereunder, except to the extent caused by Landlord’s willful misconduct or gross negligence.

19.2.         Notwithstanding any provision of Section 19.1 to the contrary, Landlord shall not be liable to Tenant for, and Tenant assumes all risk of, damage to personal property or scientific research, including, without limitation, loss of records kept by Tenant within the Premises and damage or losses caused by fire, electrical malfunction, gas explosion or water damage of any type (including, without limitation, broken water lines, malfunctioning fire sprinkler systems, roof leaks or stoppages of lines), unless any such loss is due to Landlord’s willful disregard of written notice by Tenant of need for a repair that Landlord is responsible to make for an unreasonable period of time, or Landlord’s willful misconduct or gross negligence.  Tenant further waives any claim for injury to Tenant’s business or loss of income relating to any such damage or destruction of personal property as described in this Section 19.2 .

19.3.         Landlord shall not be liable for any damages arising from any act, omission or neglect of any third party in connection with the Premises.

19.4.         Tenant acknowledges that security devices and services, if any, while intended to deter crime, may not in given instances prevent theft or other criminal acts.  Landlord shall not be liable for injuries or losses caused by criminal acts of third parties, and Tenant assumes the risk that any security device or service may malfunction or otherwise be circumvented by a criminal.  If Tenant desires protection against such criminal acts, then Tenant shall, at Tenant’s sole cost and expense, obtain appropriate insurance coverage.

19.5.         The provisions of this Section 19 shall survive the expiration or earlier termination of this Lease.

20.            Insurance; Waiver of Subrogation .

20.1.         Landlord shall maintain insurance for the Property and the Building in amounts equal to full replacement cost (exclusive of the costs of excavation, foundations and footings, and without reference to depreciation taken by Landlord upon its books or tax returns). Landlord, subject to availability thereof, shall further insure, if Landlord deems it appropriate, coverage against flood, environmental hazard, earthquake, loss or failure of building equipment, rental loss during the period of repairs or rebuilding, workmen’s compensation insurance and fidelity bonds for employees employed to perform services.  Notwithstanding the foregoing, Landlord may, but shall not be deemed required to, provide insurance for any improvements installed by Tenant or that are in addition to the standard improvements customarily furnished by Landlord, but only to the extent such are made a part of or are affixed to the Building.

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20.2.         In addition, Landlord shall carry public liability insurance with a single limit of not less than One Million Dollars ($1,000,000) for death or bodily injury, or property damage with respect to the Property.

20.3.         Tenant shall, at its own cost and expense, procure and maintain in effect, beginning on the Term Commencement Date or the date of occupancy, whichever occurs first, and continuing throughout the Term (and occupancy by Tenant, if any, after termination of this Lease) comprehensive public liability insurance with limits of not less than Two Million Dollars ($2,000,000) per occurrence for death or bodily injury and not less than One Million Dollars ($1,000,000) for property damage with respect to the Premises.

20.4.         The insurance required to be purchased and maintained by Tenant pursuant to this Lease shall name Landlord, BioMed Realty, L.P., BioMed Realty Trust, Inc., and their respective officers, employees, agents, general partners, members and Lenders (“ Landlord Parties ”) as additional insureds. Said insurance shall be with companies having a rating of not less than policyholder rating of A and financial category rating of at least Class XII in “Best’s Insurance Guide.” Tenant shall obtain for Landlord from the insurance companies or cause the insurance companies to furnish certificates of coverage to Landlord.  No such policy shall be cancelable or subject to reduction of coverage or other modification or cancellation except after thirty (30) days’ prior written notice to Landlord from the insurer.  All such policies shall be written as primary policies, not contributing with and not in excess of the coverage that Landlord may carry. Tenant’s policy may be a “blanket policy” that specifically provides that the amount of insurance shall not be prejudiced by other losses covered by the policy.  Tenant shall, at least twenty (20) days prior to the expiration of such policies, furnish Landlord with renewals or binders. Tenant agrees that if Tenant does not take out and maintain such insurance, Landlord may (but shall not be required to) procure said insurance on Tenant’s behalf and at its cost to be paid by Tenant as Additional Rent.

20.5.         Tenant assumes the risk of damage to any fixtures, goods, inventory, merchandise, equipment and leasehold improvements, and Landlord shall not be liable for injury to Tenant’s business or any loss of income therefrom, relative to such damage, except to the extent caused by Landlord’s gross negligence or intentional misconduct. Tenant shall, at Tenant’s sole cost and expense, carry such insurance as Tenant desires for Tenant’s protection with respect to personal property of Tenant or business interruption.

20.6.         In each instance where insurance is to name Landlord Parties as additional insureds, Tenant shall, upon Landlord’s written request, also designate and furnish certificates evidencing such Landlord Parties as additional insureds to (a) any Lender of Landlord holding a security interest in the Premises or any portion thereof, (b) the landlord under any lease whereunder Landlord is a tenant of the real property upon which the Building is located if the interest of Landlord is or shall become that of a tenant under a ground lease rather than that of a fee owner, and (c) any management company retained by Landlord to manage the Premises.

20.7.         Landlord and Tenant each hereby waive any and all rights of recovery against the other or against the officers, directors, employees, agents and representatives of the other on account of loss or damage occasioned by such waiving party or its property or the property of others under such waiving party’s control, in each case to the extent that such loss or damage is insured against under any fire and extended coverage insurance policy that either Landlord or Tenant may have in force at the time of such loss or damage.  Such waivers shall continue so long as their respective insurers so permit.  Any termination of such a waiver shall be by written notice to the other party, containing a description of the circumstances hereinafter set forth in this Section 20.7 . Landlord and Tenant, upon obtaining the policies of insurance required or permitted under this Lease, shall give notice to the insurance carrier or carriers that the foregoing mutual waiver of subrogation is contained in this Lease.  If such policies shall not be obtainable with such waiver or shall be so obtainable only at a premium over that chargeable without such waiver, then the party seeking such policy shall notify the other of such conditions, and the party so notified shall have ten (10) days thereafter to either (a) procure such insurance with companies reasonably satisfactory to the other party or (b) agree to pay such additional premium. If the parties do not accomplish either (a) or (b), then this Section 20.7 shall have no effect during such time as such policies shall not be obtainable or the party in whose favor a waiver of subrogation is desired refuses to pay the additional premium.  If such policies shall at any time be unobtainable, but shall be subsequently obtainable, then neither party shall be subsequently

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liable for a failure to obtain such insurance until a reasonable time after notification thereof by the other party.  If the release of either Landlord or Tenant, as set forth in the first sentence of this Section 20.7 , shall contravene Applicable Laws, then the liability of the party in question shall be deemed not released but shall be secondary to the other party’s insurer.

20.8.         Any costs incurred by Landlord pursuant to this Section 20 shall be included as Insurance Costs payable by Tenant pursuant to this Lease.

21.            Damage or Destruction .

21.1.         In the event of a partial destruction of the Premises by fire or other perils covered by extended coverage insurance not exceeding 50% of the full insurable value thereof, and provided that the damage thereto is such that the Premises may be repaired, reconstructed or restored within a period of 12 months from the date of the happening of such casualty.  Landlord shall commence and proceed diligently with the work of repair, reconstruction and restoration of the Premises, and this Lease shall continue in full force and effect.

21.2.         In the event of any damage to or destruction of the Premises other than as described in Section 21.1 , Landlord may elect to repair, reconstruct and restore the Premises, in which case this Lease shall continue in full force and effect.  If Landlord elects not to repair the Premises, then this Lease shall terminate as of the date of such damage or destruction.

21.3.         Landlord shall give written notice to Tenant of its election not to repair, reconstruct or restore the Premises within sixty (60) days following the date of damage or destruction.

21.4.         Upon any termination of this Lease under any of the provisions of this Section 21 , the parties shall be released thereby without further obligation to the other from the date possession of the Premises is surrendered to the Landlord, except with regard to (a) items occurring prior to the damage or destruction and (b) provisions of this Lease that, by their express terms, survive the expiration or earlier termination hereof.

21.5.         In the event of repair, reconstruction and restoration as provided in this Section 21 , all Rent to be paid by Tenant under this Lease shall be abated proportionately based on the extent to which Tenant’s use of the Premises is impaired during the period of such repair, reconstruction or restoration, unless Landlord provides Tenant with other space during the period of repair that, in Tenant’s reasonable opinion, is suitable for the temporary conduct of Tenant’s business.

21.6.         Notwithstanding anything to the contrary contained in this Section 21 , should Landlord be delayed or prevented from completing the repair, reconstruction or restoration of the damage or destruction to the Premises after the occurrence of such damage or destruction by Force Majeure, then the time for Landlord to commence or complete repairs shall be extended on a day-for-day basis; provided , however , that, if such Force Majeure event continues for more than 120 days, Tenant shall have the right to terminate this Lease.  Tenant shall be released from any obligations under this Lease (except with regard to those provisions that, by their express terms, survive the expiration or earlier termination hereof) if, on the date that is 12 months after the date of damage or destruction, the repair, reconstruction or restoration required to be performed by Landlord to provide Tenant use of the Premises is not then Substantially Completed.

21.7.         If Landlord is obligated to or elects to repair, reconstruct or restore as herein provided, then Landlord shall be obligated to make such repair, reconstruction or restoration only with regard to those portions of the Premises that were originally provided at Landlord’s expense. The repair, reconstruction or restoration of improvements not originally provided by Landlord or at Landlord’s expense shall be the obligation of Tenant.  In the event Tenant has elected to upgrade certain improvements from the Building Standard, Landlord shall, upon the need for replacement due to an insured loss, provide only the Building Standard, unless Tenant again elects to upgrade such improvements and pay any incremental costs related thereto, except to the extent that excess insurance proceeds, if received, are adequate to provide such upgrades, in addition to providing for basic repair, reconstruction and restoration of the Premises.

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21.8.         Notwithstanding anything to the contrary contained in this Section 21 , Landlord shall not have any obligation whatsoever to repair, reconstruct or restore the Premises if the damage resulting from any casualty covered under this Section 21 occurs during the last eighteen (18) months of the Term or any extension hereof, or to the extent that insurance proceeds are not available therefore, unless such lack of availability is due to Landlord’s failure to maintain insurance in accordance with this Lease.

21.9.         Landlord’s obligation, should it elect or be obligated to repair or rebuild, shall be limited to the Premises; provided that Tenant shall, at its expense, replace or fully repair all of Tenant’s personal property.  If the Premises are to be repaired in accordance with the foregoing, Landlord shall make available to Tenant any portion of insurance proceeds it receives that are allocable to the alterations constructed by Tenant pursuant to this Lease, provided Tenant is not then in default under this Lease.

22.            Eminent Domain .

22.1.         In the event the whole of the Premises, or such part thereof as shall substantially interfere with the Tenant’s use and occupancy thereof, shall be taken for any public or quasi-public purpose by any lawful power or authority by exercise of the right of appropriation, condemnation or eminent domain, or sold to prevent such taking, Tenant or Landlord may terminate this Lease effective as of the date possession is required to be surrendered to said authority.

22.2.         In the event of a partial taking of the Premises, or of drives, walkways or parking areas serving the Premises for any public or quasi-public purpose by any lawful power or authority by exercise of right of appropriation, condemnation, or eminent domain, or sold to prevent such taking, then, without regard to whether any portion of the Premises occupied by Tenant was so taken, Landlord may elect to terminate this Lease as of such taking if such taking is, in Landlord’s reasonable opinion,  of a material nature such as to make it uneconomical to continue use of the unappropriated portion for purposes of renting office or laboratory space.

22.3.         Tenant shall be entitled to any award that is specifically awarded as compensation for (a) the taking of Tenant’s personal property that was installed at Tenant’s expense and (b) the costs of Tenant moving to a new location.  Except as set forth in the previous sentence, any award for such taking shall be the property of Landlord.

22.4.         If, upon any taking of the nature described in this Section 22 , this Lease continues in effect, then Landlord shall promptly proceed to restore the Premises to substantially their same condition prior to such partial taking.  To the extent such restoration is feasible, as determined by Landlord in its reasonable discretion, the Rent shall be decreased by a number, the numerator of which is the rental value of the Premises prior to such taking, and the denominator of which is the value of the Premises after such taking.

23.            Defaults and Remedies .

23.1.         Late payment by Tenant to Landlord of Rent and other sums due shall cause Landlord to incur costs not contemplated by this Lease, the exact amount of which shall be extremely difficult and impracticable to ascertain.  Such costs include, but are not limited to, processing and accounting charges and late charges that may be imposed on Landlord by the terms of any mortgage or trust deed covering the Premises.  Therefore, if any installment of Rent due from Tenant is not received by Landlord within five (5) days after the date such payment is due, Tenant shall pay to Landlord an additional sum of five percent (5%) of the overdue Rent as a late charge.  The parties agree that this late charge represents a fair and reasonable estimate of the costs that Landlord shall incur by reason of late payment by Tenant.  In addition to the late charge, Rent not paid when due shall bear interest from the fifth (5 th ) day after the date due until paid at the lesser of (a) twelve percent (12%) per annum or (b) the maximum rate permitted by Applicable Laws.

23.2.         No payment by Tenant or receipt by Landlord of a lesser amount than the Rent payment herein stipulated shall be deemed to be other than on account of the Rent, nor shall any endorsement or statement on any check or any letter accompanying any check or payment as Rent be deemed an accord and satisfaction, and Landlord may accept such check or payment without prejudice to Landlord’s right to recover the balance of such Rent or pursue any other

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remedy provided in this Lease or in equity or at law.  If a dispute shall arise as to any amount or sum of money to be paid by Tenant to Landlord hereunder, Tenant shall have the right to make payment “under protest,” such payment shall not be regarded as a voluntary payment, and there shall survive the right on the part of Tenant to institute suit for recovery of the payment paid under protest.

23.3.         If Tenant fails to pay any sum of money (other than Basic Annual Rent or Rental Adjustments) required to be paid by it hereunder, or shall fail to perform any other act on its part to be performed hereunder, Landlord may, without waiving or releasing Tenant from any obligations of Tenant, but shall not be obligated to, make such payment or perform such act; provided that such failure by Tenant continues for 5 days after Landlord delivers notice to Tenant demanding performance by Tenant; or that such failure by Tenant unreasonably interfered with the efficient operation of the Premises, or resulted or could have resulted in a violation of Applicable Laws or the cancellation of an insurance policy maintained by Landlord. Tenant shall pay to Landlord as Additional Rent all sums so paid or incurred by Landlord, together with interest thereon, from the date such sums were paid or incurred, at the annual rate equal to twelve percent (12%) per annum or highest rate permitted by Applicable Laws, whichever is less.

23.4.         The occurrence of any one or more of the following events shall constitute a “ Default ” hereunder by Tenant:

(a)            The abandonment or vacation of the Premises by Tenant;

(b)            The failure by Tenant to make any payment of Rent, as and when due, where such failure shall continue for a period of 5 days after written notice thereof from Landlord to Tenant;

(c)            The failure by Tenant to observe or perform any obligation or covenant contained herein (other than described in Subsections 23.4(a) and 23.4(b)) to be performed by Tenant, where such failure shall continue for a period of 30 days after written notice thereof from Landlord to Tenant; provided that, if the nature of Tenant’s default is such that it reasonably requires more than 30 days to cure, Tenant shall not be deemed to be in default if Tenant shall commence such cure within said 30-day period and thereafter diligently prosecute the same to completion;

(d)            Tenant makes an assignment for the benefit of creditors;

(e)            A receiver, trustee or custodian is appointed to or does take title, possession or control of all or substantially all of Tenant’s assets;

(f)             Tenant files a voluntary petition under the United States Bankruptcy Code or any successor statute (the “ Code ”) or an order for relief is entered against Tenant pursuant to a voluntary or involuntary proceeding commenced under any chapter of the Code;

(g)            Any involuntary petition if filed against Tenant under any chapter of the Code and is not dismissed within one hundred twenty (120) days;

(h)            Failure to deliver an estoppel certificate within 5 days of the time period required in accordance with Section 28 ; or

(i)             Tenant’s interest in this Lease is attached, executed upon or otherwise judicially seized and such action is not released within one hundred twenty (120) days of the action.

(j)             Notices given under this Section 23.4 shall specify the alleged default and shall demand that Tenant perform the provisions of this Lease or pay the Rent that is in arrears, as the case may be, within the applicable period of time, or quit the Premises.  No such notice shall be deemed a forfeiture or a termination of this Lease unless Landlord elects otherwise in such notice.

(k)            Notwithstanding any other provision in this Section 23.4 , in the event the occurrence of any of the events specified in subparagraphs (a) through (j) above cause a

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condition that poses an imminent threat to the public health, safety or welfare, the applicable cure periods set forth in such subparagraph shall not apply, and the occurrence of such event shall immediately constitute a material “Default” hereunder.

23.5.         In the event of a Default by Tenant, and at any time thereafter, with or without notice or demand and without limiting Landlord in the exercise of any right or remedy that Landlord may have, Landlord shall be entitled to terminate Tenant’s right to possession of the Premises by any lawful means, in which case this Lease shall terminate and Tenant shall immediately surrender possession of the Premises to Landlord.  In such event, Landlord shall have the immediate right to re-enter and remove all persons and property, and such property may be removed and stored in a public warehouse or elsewhere at the cost and for the account of Tenant, all without service of notice or resort to legal process and without being deemed guilty of trespass or becoming liable for any loss or damage that may be occasioned thereby.  In the event that Landlord shall elect to so terminate this Lease, then Landlord shall be entitled to recover from Tenant all damages incurred by Landlord by reason of Tenant’s default, including, without limitation:

(a)            The worth at the time of award of any unpaid Rent that had accrued at the time of such termination; plus

(b)            The worth at the time of award of the amount by which the unpaid Rent that would have accrued during the period commencing with termination of the Lease and ending at the time of award exceeds that portion of the loss of Landlord s rental income from the Premises that Tenant proves to Landlord s reasonable satisfaction could have been reasonably avoided; plus

(c)            The worth at the time of award of the amount by which the unpaid Rent for the balance of the Term after the time of award exceeds that portion of the loss of Landlord’s rental income from the Premises that Tenant proves to Landlord s reasonable satisfaction could have been reasonably avoided; plus

(d)            Any other amount necessary to compensate Landlord for all the detriment proximately caused by Tenant’s failure to perform its obligations under this Lease or that in the ordinary course of things would be likely to result therefrom, including, without limitation, the cost of restoring the Premises to the condition required under the terms of this Lease; plus

(e)            At Landlord’s election, such other amounts in addition to or in lieu of the foregoing as may be permitted from time to time by Applicable Laws.

As used in Subsections 23.5(a) and 23.5(b) , “worth at the time of award” shall be computed by allowing interest at the rate specified in Section 23.1 . As used in Subsection 23.5(c) above, the “worth at the time of the award” shall be computed by taking the present value of such amount, using the discount rate of the Federal Reserve Bank of San Francisco at the time of the award plus one (1) percentage points.

23.6.         If Landlord does not elect to terminate this Lease as provided in Section 23.5 , then Landlord may, from time to time, recover all Rent as it becomes due under this Lease.  At any time thereafter, Landlord may elect to terminate this Lease and to recover damages to which Landlord is entitled.

23.7.         In the event Landlord elects to terminate this Lease and relet the Premises, Landlord may execute any new lease in its own name.  Tenant hereunder shall have no right or authority whatsoever to collect any Rent from such tenant.  The proceeds of any such reletting shall be applied as follows:

(a)            First, to the payment of any indebtedness other than Rent due hereunder from Tenant to Landlord, including, without limitation, storage charges or brokerage commissions owing from Tenant to Landlord as the result of such reletting;

(b)            Second, to the payment of the costs and expenses of reletting the Premises, including (i) alterations and repairs that Landlord deems reasonably necessary and advisable and (ii) reasonable attorneys’ fees, charges and disbursements incurred by Landlord in connection with the retaking of the Premises and such reletting;

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(c)            Third, to the payment of Rent and other charges due and unpaid hereunder; and

(d)            Fourth, to the payment of future Rent and other damages payable by Tenant under this Lease.

23.8.         All of Landlord’s rights, options and remedies hereunder shall be construed and held to be nonexclusive and cumulative.  Landlord shall have the right to pursue any one or all of such remedies, or any other remedy or relief that may be provided by Applicable Laws, whether or not stated in this Lease.  No waiver of any default of Tenant hereunder shall be implied from any acceptance by Landlord of any Rent or other payments due hereunder or any omission by Landlord to take any action on account of such default if such default persists or is repeated, and no express waiver shall affect defaults other than as specified in said waiver.

23.9.         Landlord’s termination of (a) this Lease or (b) Tenant’s right to possession of the Premises shall not relieve Tenant of any liability to Landlord that has previously accrued or that shall arise based upon events that occurred prior to the later to occur of (i) the date of Lease termination or (ii) the date Tenant surrenders possession of the Premises.

23.10.       To the extent permitted by Applicable Laws, Tenant waives any and all rights of redemption granted by or under any present or future Applicable Laws if Tenant is evicted or dispossessed for any cause, or if Landlord obtains possession of the Premises due to Tenant’s default hereunder or otherwise.

23.11.       Landlord shall not be in default under this Lease unless Landlord fails to perform obligations required of Landlord within a reasonable time, but in no event shall such failure to continue for more than thirty (30) days after written notice from Tenant specifying the nature of Landlord’s failure; provided , however , that if the nature of Landlord’s obligation is such that more than thirty (30) days are required for its performance, then Landlord shall not be in default if Landlord commences performance within such thirty (30) day period and thereafter diligently prosecutes the same to completion.

23.12.       In the event of any default by Landlord, Tenant shall give notice by registered or certified mail to any (a) beneficiary of a deed of trust or (b) mortgagee under a mortgage covering the Premises or any portion thereof and to any landlord of any lease of land upon or within which the Premises are located, and shall offer such beneficiary, mortgagee or landlord a reasonable opportunity to cure the default, including time to obtain possession of the Premises by power of sale or a judicial action if such should prove necessary to effect a cure; provided that Landlord shall promptly furnish to Tenant in writing, upon written request by Tenant, the names and addresses of all such persons who are to receive such notices.

24.            Assignment or Subletting .

24.1.         Except as hereinafter provided, Tenant shall not, either voluntarily or by operation of Applicable Laws, directly or indirectly sell, hypothecate, assign, pledge, encumber or otherwise transfer this Lease, or sublet the Premises or any part hereof (each, a “ Transfer ”), without Landlord’s prior written consent, which consent Landlord may not unreasonably withhold or delay; provided that, without the consent of Landlord, Tenant may assign this Lease to a party that acquires substantially all the assets of or equity in Tenant.

24.2.         In the event Tenant desires to effect a Transfer, then, at least forty-five (45) but not more than ninety (90) days prior  to the date when Tenant desires the assignment or sublease to be effective (the “ Assignment Date ”), Tenant shall provide written notice to Landlord (the “ Assignment Notice ”) containing information (including references) concerning the character of the proposed transferee, assignee or sublessee; the Assignment Date; any ownership or commercial relationship between Tenant and the proposed transferee, assignee or sublessee; and the consideration and all other material terms and conditions of the proposed Transfer, all in such detail as Landlord shall reasonably require. Tenant shall also tender to Landlord reasonable attorneys’ fees and other costs or overhead expenses incurred by Landlord in reviewing Tenant’s request for such Transfer; provided that such costs and expenses shall not exceed $2,000.00.

24.3.         Landlord, in determining whether consent should be given to a proposed Transfer, may give consideration to the financial strength of such transferee, assignee or sublessee

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(notwithstanding Tenant remaining liable for Tenant’s performance), any change in use that such transferee, assignee or sublessee proposes to make in the use of the Premises.  In no event shall Landlord be deemed to be unreasonable for declining to consent to a Transfer to a transferee, assignee or sublessee of poor reputation, lacking financial qualifications, seeking a material change in the Permitted Use, or jeopardizing directly or indirectly the status of Landlord or any of Landlord’s affiliates as a Real Estate Investment Trust under the Code.

24.4.         As conditions precedent to Tenant subleasing or transferring any rights to the Premises, Landlord may require any or all of the following:

(a)            Tenant shall remain fully liable under this Lease during the unexpired Term;

(b)            Tenant shall provide Landlord with evidence reasonably satisfactory to Landlord respecting the relevant business experience and financial responsibility and status of the proposed transferee, assignee or sublessee;

(c)            Tenant shall reimburse Landlord for Landlord’s actual costs and expenses, including, without limitation, reasonable attorneys’ fees, charges and disbursements incurred in connection with the review, processing and documentation of such request; provided that such costs and expenses shall not exceed $2,000.00.

(d)            If Tenant’s transfer of rights or sharing of the Premises provides for the receipt by, on behalf of or on account of Tenant of any consideration of any kind whatsoever (including, without limitation, a premium rental for a sublease or lump sum payment for an assignment, but excluding Tenant’s reasonable costs in marketing and subleasing the Premises) in excess of the rental and other charges due to Landlord under this Lease, Tenant shall pay fifty percent (50%) of all of such excess to Landlord, after deductions for any transaction costs incurred by Tenant, including marketing expenses, tenant improvement allowances, alterations, cash concessions, brokerage commissions, attorneys’ fees and free rent..  If said consideration consists of cash paid to Tenant, payment to Landlord shall be made upon receipt by Tenant of such cash payment;

(e)            The proposed transferee, assignee or sublessee shall agree that, in the event Landlord gives such proposed transferee, assignee or sublessee notice that Tenant is in default under this Lease, such proposed transferee, assignee or sublessee shall thereafter make all payments otherwise due Tenant directly to Landlord, which payments shall be received by Landlord without any liability being incurred by Landlord, except to credit such payment against those due by Tenant under this Lease, and any such proposed transferee, assignee or sublessee shall agree to attorn to Landlord or its successors and assigns should this Lease be terminated for any reason; provided , however , that in no event shall Landlord or its Lenders, successors or assigns be obligated to accept such attornment;

(f)             Any such Transfer shall be effected on Landlord’s forms;

(g)            Tenant shall not then be in material default hereunder in any respect;

(h)            Landlord shall not be bound by any provision of any agreement pertaining to the Transfer, without Landlord’s written agreement to the same;

(i)             Tenant shall deliver to Landlord one executed copy of any and all written instruments evidencing the Transfer; and

(j)             A list of Hazardous Materials (as defined in Section 38.7 below), certified by the proposed transferee, assignee or sublessee to be true and correct, that the proposed transferee, assignee or sublessee intends to use or store in the Premises.  Additionally, Tenant shall deliver to Landlord, on or before the date any proposed transferee, assignee or sublessee takes occupancy of the Premises, all of the items relating to Hazardous Materials of such proposed transferee, assignee or sublessee as described in Section 38.2 .

24.5.         Any Transfer that is not in compliance with the provisions of this Section 24 shall be void and shall, at the option of Landlord, terminate this Lease.

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24.6.         The consent by Landlord to a Transfer shall not relieve Tenant or proposed transferee, assignee or sublessee from obtaining Landlord’s consent to any further Transfer, nor shall it release Tenant or any proposed transferee, assignee or sublessee of Tenant from full and primary liability under this Lease unless otherwise agreed in writing by Landlord.

24.7.         Notwithstanding any Transfer, Tenant shall remain fully and primarily liable for the payment of all Rent and other sums due or to become due hereunder, and for the full performance of all other terms, conditions and covenants to be kept and performed by Tenant, unless otherwise agreed in writing by Landlord.  The acceptance of Rent or any other sum due hereunder, or the acceptance of performance of any other term, covenant or condition thereof, from any person or entity other than Tenant shall not be deemed a waiver of any of the provisions of this Lease or a consent to any Transfer.

24.8.         If Tenant delivers to Landlord an Assignment Notice indicating a desire to transfer this Lease to a proposed transferee, assignee or sublessee other than as provided within Section 24.4 , then Landlord shall have the option, exercisable by giving notice to Tenant at any time within ten (10) days after Landlord’s receipt of such Assignment Notice, to terminate this Lease as of the date specified in the Assignment Notice as the Assignment Date, except for those provisions that, by their express terms, survive the expiration or earlier termination hereof.  If Landlord exercises such option, then Tenant shall have the right to withdraw such Assignment Notice by delivering to Landlord written notice of such election within five (5) days after Landlord’s delivery of notice electing to exercise Landlord’s option to terminate this Lease.  In the event Tenant withdraws the Assignment Notice as provided in this Section 24.8 , this Lease shall continue in full force and effect.  No failure of Landlord to exercise its option to terminate this Lease shall be deemed to be Landlord’s consent to a proposed Transfer.

24.9.         If Tenant sublets the Premises or any portion thereof, Tenant hereby immediately and irrevocably assigns to Landlord, as security for Tenant’s obligations under this Lease, all rent from any such subletting, and appoints Landlord as assignee and attorney-in-fact for Tenant, and Landlord (or a receiver for Tenant appointed on Landlord’s application) may collect such rent and apply it toward Tenant’s obligations under this Lease; provided that, until the occurrence of a Default by Tenant, Tenant shall have the right to collect such rent.

25.            Attorneys’ Fees .  If either party commences an action against the other party arising out of or in connection with this Lease, then the prevailing party shall be entitled to have and recover from the non-prevailing party reasonable attorneys’ fees, charges and disbursements and costs of suit.

26.            Bankruptcy .  In the event a debtor, trustee or debtor in possession under the Code, or another person with similar rights, duties and powers under any other Applicable Laws, proposes to cure any default under this Lease or to assume or assign this Lease and is obliged to provide adequate assurance to Landlord that (a) a default shall be cured, (b) Landlord shall be compensated for its damages arising from any breach of this Lease and (c) future performance of Tenant’s obligations under this Lease shall occur, then such adequate assurances shall include any or all of the following, as designated by Landlord in its sole and absolute discretion:

26.1.         Those acts specified in the Code or other Applicable Laws as included within the meaning of “adequate assurance,” even if this Lease does not concern a shopping center or other facility described in such Applicable Laws;

26.2.         A prompt cash payment to compensate Landlord for any monetary defaults or actual damages arising directly from a breach of this Lease;

26.3.         A cash deposit in an amount at least equal to the then-current amount of the Security Deposit; or

26.4.         The assumption or assignment of all of Tenant’s interest and obligations under this Lease.

27.            Definition of Landlord .  With regard to obligations imposed upon Landlord pursuant to this Lease, the term “ Landlord ,” as used in this Lease, shall refer only to Landlord or Landlord’s then-current successor-in-interest.  In the event of any transfer, assignment or conveyance of Landlord’s interest in this Lease or in Landlord’s fee title to or leasehold interest in the Property,

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as applicable, the Landlord herein named (and in case of any subsequent transfers or conveyances, the subsequent Landlord) shall be automatically freed and relieved, from and after the date of such transfer, assignment or conveyance, from all liability for the performance of any covenants or obligations contained in this Lease thereafter to be performed by Landlord and, without further agreement, the transferee, assignee or conveyee of Landlord’s in this Lease or in Landlord’s fee title to or leasehold interest in the Property, as applicable, shall be deemed to have assumed and agreed to observe and perform any and all covenants and obligations of Landlord hereunder during the tenure of its interest in the Lease or the Property.  Landlord or any subsequent Landlord may transfer its interest in the Premises or this Lease without Tenant’s consent.

28.            Estoppel Certificate . Tenant shall, within ten (10) days of receipt of written notice from Landlord, execute, acknowledge and deliver a statement in writing substantially in the form attached to this Lease as Exhibit E , or on any other form reasonably requested by a proposed Lender or purchaser, (a) certifying that this Lease is unmodified and in full force and effect (or, if modified, stating the nature of such modification and certifying that this Lease as so modified is in full force and effect) and the dates to which rental and other charges are paid in advance, if any, (b) acknowledging that there are not, to Tenant’s knowledge, any uncured defaults on the part of Landlord hereunder, or specifying such defaults if any are claimed, and (c) setting forth such further information with respect to this Lease or the Premises as may be requested thereon. Any such statement may be relied upon by any prospective purchaser or encumbrancer of all or any portion of the real property of which the Premises are a part.  Tenant’s failure to deliver such statement within 5 days of the prescribed time shall, at Landlord’s option, constitute a Default under this Lease, and, in any event, shall be binding upon Tenant that the Lease is in full force and effect and without modification except as may be represented by Landlord in any certificate prepared by Landlord and delivered to Tenant for execution.

29.            Joint and Several Obligations . If more than one person or entity executes this Lease as Tenant, then:

29.1.         Each of them is jointly and severally liable for the keeping, observing and performing of all of the terms, covenants, conditions, provisions and agreements of this Lease to be kept, observed or performed by Tenant; and

29.2.         The term “ Tenant ” as used in this Lease shall mean and include each of them, jointly and severally. The act of, notice from, notice to, refund to, or signature of any one or more of them with respect to the tenancy under this Lease, including, without limitation, any renewal, extension, expiration, termination or modification of this Lease, shall be binding upon each and all of the persons executing this Lease as Tenant with the same force and effect as if each and all of them had so acted, so given or received such notice or refund, or so signed.

30.            Limitation of Landlord’s Liability .

30.1.         If Landlord is in default under this Lease and, as a consequence, Tenant recovers a monetary judgment against Landlord, the judgment shall be satisfied only out of (a) the proceeds of sale received on execution of the judgment and levy against the right, title and interest of Landlord in the Premises, (b) rent or other income from such real property receivable by Landlord or (c) the consideration received by Landlord from the sale, financing, refinancing or other disposition of all or any part of Landlord’s right, title or interest in the Premises.

30.2.         If Landlord is a partnership or joint venture, then the partners of such partnership shall not be personally liable for Landlord’s obligations under this Lease, and no partner of Landlord shall be sued or named as a party in any suit or action, and service of process shall not be made against any partner of Landlord except as may be necessary to secure jurisdiction of the partnership or joint venture. If Landlord is a corporation, then the shareholders, directors, officers, employees and agents of such corporation shall not be personally liable for Landlord’s obligations under this Lease, and no shareholder, director, officer, employee or agent of Landlord shall be sued or named as a party in any suit or action, and service of process shall not be made against any shareholder, director, officer, employee or agent of Landlord, except as may be necessary to secure jurisdiction of the corporation.  If Landlord is a limited liability company, then the members of such limited liability company shall not be personally liable for Landlord’s obligations under this Lease, and no member of Landlord shall be sued or named as a party in any suit or action, and service of process shall not be made against any member of Landlord

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except as may be necessary to secure jurisdiction of the limited liability company.  No partner, shareholder, director, employee, member or agent of Landlord shall be required to answer or otherwise plead to any service of process, and no judgment shall be taken or writ of execution levied against any partner, shareholder, director, employee or agent of Landlord.

30.3.         Each of the covenants and agreements of this Section 30 shall be applicable to any covenant or agreement either expressly contained in this Lease or imposed by Applicable Laws and shall survive the expiration or earlier termination of this Lease.

31.            Premises Control by Landlord .

31.1.         Landlord reserves full control over the Premises to the extent not inconsistent with Tenant’s enjoyment of the same as provided by this Lease.  This reservation includes, without limitation, Landlord’s right to subdivide the Property, convert the Building to condominium units, grant easements and licenses to third parties, and maintain or establish ownership of the Building separate from fee title to the Property.

31.2.         Tenant shall, at Landlord’s request, promptly execute such further documents as may be reasonably appropriate to assist Landlord in the performance of its obligations hereunder; provided that Tenant need not execute any document that creates additional liability for Tenant or that deprives Tenant of the quiet enjoyment and use of the Premises as provided by this Lease.

31.3.         Landlord may, at any and all reasonable times during non-business hours (or during business hours if Tenant so requests), and upon twenty-four (24) hours’ prior notice ( provided that no time restrictions shall apply or advance notice be required if an emergency necessitates immediate entry), enter the Premises to (a) inspect the same and to determine whether Tenant is in compliance with its obligations hereunder, (b) supply any service Landlord is required to provide hereunder, (c) show the Premises to prospective purchasers or tenants during the final year of the Term, (d) post notices of nonresponsibility and (e) access the telephone equipment, electrical substation and fire risers.  In connection with any such alteration, improvement or repair as described in Section 17.4 above, Landlord may erect in the Premises scaffolding and other structures reasonably required for the alteration, improvement or repair work to be performed.  In no event shall Tenant’s Rent abate as a result of Landlord’s activities pursuant to this Section 31.3 ; provided , however , that all such activities shall be conducted in such a manner so as to cause as little interference to Tenant as is reasonably possible, and such activities shall not materially interfere with Tenant’s use and quiet enjoyment of the Premises. Landlord shall at all times retain a key with which to unlock all of the doors in the Premises.  If an emergency necessitates immediate access to the Premises, Landlord may use whatever force is necessary to enter the Premises, and any such entry to the Premises shall not constitute a forcible or unlawful entry to the Premises, a detainer of the Premises, or an eviction of Tenant from the Premises or any portion thereof.

32.            Quiet Enjoyment . So long as Tenant is not in default under this Lease, Landlord or anyone acting through or under Landlord shall not disturb Tenant’s occupancy of the Premises, except as permitted by this Lease.

33.            Subordination and Attornment .

33.1.         This Lease shall be subject and subordinate to the lien of any mortgage, deed of trust, or lease in which Landlord is tenant now or hereafter in force against the Premises or any portion thereof and to all advances made or hereafter to be made upon the security thereof without the necessity of the execution and delivery of any further instruments on the part of Tenant to effectuate such subordination.

33.2.         Notwithstanding the foregoing, Tenant shall execute and deliver upon demand such further instrument or instruments evidencing such subordination of this Lease to the lien of any such mortgage or mortgages or deeds of trust or lease in which Landlord is tenant as may be required by Landlord. However, if any such mortgagee, beneficiary or Landlord under lease wherein Landlord is tenant so elects, this Lease shall be deemed prior in lien to any such lease, mortgage, or deed of trust upon or including the Premises regardless of date and Tenant shall execute a statement in writing to such effect at Landlord’s request.  If Tenant fails to execute any document required from Tenant under this Section within ten (10) days after written request therefor, Tenant hereby constitutes and appoints Landlord or its special attorney-in-fact to

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execute and deliver any such document or documents in the name of Tenant.  Such power is coupled with an interest and is irrevocable.

33.3.         In the event any proceedings are brought for foreclosure, or in the event of the exercise of the power of sale under any mortgage or deed of trust made by the Landlord covering the Premises, the Tenant shall at the election of the purchaser at such foreclosure or sale attorn to the purchaser upon any such foreclosure or sale and recognize such purchaser as the Landlord under this Lease.

33.4.         Notwithstanding anything to the contrary contained herein, so long as Tenant is not in default under this Lease, its peaceful use and occupancy of the Premises under this Lease shall not be impaired, restricted or terminated by any mortgagee, grand lessor, beneficiary, or secured party.

34.            Surrender .

34.1.         No surrender of possession of any part of the Premises shall release Tenant from any of its obligations hereunder, unless such surrender is accepted in writing by Landlord.

34.2.         The voluntary or other surrender of this Lease by Tenant shall not effect a merger with Landlord’s fee title or leasehold interest in the Premises or any portion thereof, unless Landlord consents in writing, and shall, at Landlord’s option, operate as an assignment to Landlord of any or all subleases.

34.3.         The voluntary or other surrender of any ground or other underlying lease that now exists or may hereafter be executed affecting the Premises or any portion thereof, or a mutual cancellation thereof or of Landlord’s interest therein by Landlord and its lessor shall not effect a merger with Landlord’s fee title or leasehold interest in the Premises and shall, at the option of the successor to Landlord’s interest in the Premises or any portion thereof operate as an assignment of this Lease.

35.            Waiver and Modification . No provision of this Lease may be modified, amended or supplemented except by an agreement in writing signed by Landlord and Tenant.  The waiver by Landlord of any breach by Tenant of any term, covenant or condition herein contained shall not be deemed to be a waiver of any subsequent breach of the same or any other term, covenant or condition herein contained.

36.            Waiver of Jury Trial and Counterclaims . The parties waive trial by jury in any action, proceeding or counterclaim brought by the other party hereto related to matters arising out of or in any way connected with this Lease; the relationship between Landlord and Tenant; Tenant’s use or occupancy of the Premises; or any claim of injury or damage related to this Lease or the Premises.

37.            [Intentionally omitted]

38.            Hazardous Materials .

38.1.         Tenant shall not cause or permit any Hazardous Materials (as hereinafter defined) to be brought upon, kept or used in or about the Premises in violation of Applicable Laws by Tenant, its agents, employees, contractors or invitees.  If Tenant breaches such obligation, or if the presence of Hazardous Materials as a result of such a breach results in contamination of the Premises or any adjacent property, or if contamination of the Premises or any adjacent property by Hazardous Materials is caused by Tenant or its agents, contractors, invitees or employees during the term of this Lease or any extension or renewal hereof or holding over hereunder, then Tenant shall indemnify, save, defend and hold Landlord, its agents and contractors harmless from and against any and all claims, judgments, damages, penalties, fines, costs, liabilities and losses (including, without limitation, diminution in value of the Premises or any portion thereof; damages for the loss or restriction on use of rentable or usable space or of any amenity of the Premises; damages arising from any adverse impact on marketing of space in the Premises; and sums paid in settlement of claims, attorneys’ fees, consultants’ fees and experts’ fees) that arise during or after the Term as a result of such breach or contamination.  This indemnification of Landlord by Tenant includes, without limitation, costs incurred in connection with any investigation of site conditions or any cleanup, remedial, removal or restoration work required by

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any Governmental Authority because of Hazardous Materials present in the air, soil or groundwater above, on or under the Premises.  Without limiting the foregoing, if the presence of any Hazardous Materials in, on, under or about the Premises or any adjacent property caused or permitted by Tenant results in any contamination of the Premises or any adjacent property, then Tenant shall promptly take all actions at its sole cost and expense as are necessary to return the Premises and any adjacent property to their respective condition existing prior to the time of such contamination; provided that Landlord’s written approval of such action shall first be obtained, which approval Landlord shall not unreasonably withhold or delay; and provided , further, that it shall be reasonable for Landlord to withhold its consent if such actions could have a material adverse long-term or short-term effect on the Premises.

38.2.         Landlord acknowledges that it is not the intent of this Section 38 to prohibit Tenant from operating its business as described in Section 2.8 above. Tenant may operate its business according to the custom of Tenant’s industry so long as the use or presence of Hazardous Materials is strictly and properly monitored according to Applicable Laws.  As a material inducement to Landlord to allow Tenant to use Hazardous Materials in connection with its business, Tenant has delivered to Landlord prior to the Term Commencement Date a list identifying each type of Hazardous Material to be present on the Premises and setting forth any and all governmental approvals or permits required in connection with the presence of such Hazardous Material on the Premises (the “ Hazardous Materials List ”). Tenant shall deliver to Landlord an updated Hazardous Materials List: (a) upon any contamination of the Premises; or (b) upon the request of Landlord, which Landlord shall not request more than once per year. Tenant shall deliver to Landlord true and correct copies of the following documents (hereinafter referred to as the “ Documents ”) relating to the handling, storage, disposal and emission of Hazardous Materials prior to the Term Commencement Date or, if unavailable at that time, concurrent with the receipt from or submission to any Governmental Authority:  permits; approvals; reports and correspondence; storage and management plans; notices of violations of Applicable Laws; plans relating to the installation of any storage tanks to be installed in or under the Premises ( provided that installation of below-ground storage tanks shall only be permitted after Landlord has given Tenant its written consent to do so, which consent Landlord may withhold in its sole and absolute discretion); and all closure plans or any other documents required by any and all Governmental Authorities for any storage tanks installed in, on or under the Premises for the closure of any such storage tanks.  Tenant shall not be required, however, to provide Landlord with any portion of the Documents containing information of a proprietary nature that, in and of themselves, do not contain a reference to any Hazardous Materials or activities related to Hazardous Materials.

38.3.         Notwithstanding the provisions of Section 38.1 above, if (a) any proposed transferee, assignee or sublessee of Tenant has been required by any prior landlord, Lender or Governmental Authority to take remedial action in connection with Hazardous Materials contaminating a property if the contamination resulted from such party’s action or omission or use of the property in question or (ii) any proposed transferee, assignee or sublessee is subject to an enforcement order issued by any Governmental Authority in connection with the use, disposal or storage of Hazardous Materials, then it shall not be unreasonable for Landlord to withhold its consent to any proposed transfer, assignment or subletting (with respect to any such matter involving a proposed transferee, assignee or sublessee).

38.4.         At any time, and from time to time,  prior to the expiration of the Term, Landlord shall have the right to conduct appropriate tests of the Premises to demonstrate that Hazardous Materials are present or that contamination has occurred due to Tenant or Tenant’s agents, employees or invitees.  Tenant shall pay all reasonable costs of such tests of the Premises.

38.5.         If underground or other storage tanks storing Hazardous Materials are located on the Premises or are hereafter placed on the Premises by any party, Tenant shall monitor the storage tanks, maintain appropriate records, implement reporting procedures, properly close any underground storage tanks, and take or cause to be taken all other steps necessary or required under the Applicable Laws.

38.6.         Tenant’s obligations under this Section 38 shall survive the expiration or earlier termination of the Lease.  During any period of time needed by Tenant or Landlord after the termination of this Lease to complete the removal from the Premises of any such Hazardous Materials, Tenant shall continue to pay Rent in accordance with this Lease, which Rent shall be

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prorated daily, but only to the extent that the Premises are rendered untenantable by such activity.

38.7.         As used herein, the term “ Hazardous Material ” means any hazardous or toxic substance, material or waste that is or becomes regulated by any Governmental Authority.

39.            [Intentionally omitted]

40.            Miscellaneous .

40.1.         This Lease shall be deemed and construed to be an “absolute net lease” and, except as herein expressly provided, Landlord shall receive all payments required to be made by Tenant free from all charges, assessments, impositions, expenses and deductions of any and every kind or nature whatsoever.  Landlord shall not be required to furnish any services or facilities or to make any repairs, replacements or alterations of any kind in or on the Premises except as specifically provided herein. Tenant shall receive all invoices and bills relative to the Premises and, except as otherwise provided herein, shall pay for all expenses directly to the person or company submitting a bill without first having to forward payment for the expenses to Landlord. Tenant shall at Tenant’s sole cost and expense be responsible for the management of the Premises, shall maintain the landscaping and parking lot, and shall make those additional repairs and alterations required of Tenant hereunder to maintain the Premises in good order, condition and repair subject to the conditions of the Premises as of the Term Commencement Date.

40.2.         Where applicable in this Lease, the singular includes the plural and the masculine or neuter includes the masculine, feminine and neuter.  The section headings of this Lease are not a part of this Lease and shall have no effect upon the construction or interpretation of any part hereof.

40.3.         Submission of this instrument for examination or signature by Tenant does not constitute a reservation of or option for a lease, and shall not be effective as a lease or otherwise until execution by and delivery to both Landlord and Tenant.

40.4.         Time is of the essence with respect to the performance of every provision of this Lease in which time of performance is a factor.

40.5.         Each provision of this Lease performable by Tenant shall be deemed both a covenant and a condition.

40.6.         Whenever consent or approval of either party is required, that party shall not unreasonably withhold such consent or approval, except as may be expressly set forth to the contrary.

40.7.         The terms of this Lease are intended by the parties as a final expression of their agreement with respect to the terms as are included herein, and may not be contradicted by evidence of any prior or contemporaneous agreement.

40.8.         Any provision of this Lease that shall prove to be invalid, void or illegal shall in no way affect, impair or invalidate any other provision hereof, and all other provisions of this Lease shall remain in full force and effect and shall be interpreted as if the invalid, void or illegal provision did not exist.

40.9.         Landlord may, but shall not be obligated to, record this Lease or a short form memorandum hereof without Tenant’s consent.  Neither party shall record this Lease.  Tenant shall be responsible for the cost of recording any memorandum of this Lease, including any transfer or other taxes incurred in connection with said recordation.

40.10.       The language in all parts of this Lease shall be in all cases construed as a whole according to its fair meaning and not strictly for or against either Landlord or Tenant.

40.11.       Each of the covenants, conditions and agreements herein contained shall inure to the benefit of and shall apply to and be binding upon the parties hereto and their respective heirs; legatees; devisees; executors; administrators; and permitted successors, assigns, sublessees.

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Nothing in this Section 40.11 shall in any way alter the provisions of this Lease restriciting assignment or subletting.

40.12.       Any notice, consent, demand, bill, statement or other communication required or permitted to be given hereunder shall be in writing and shall be given by personal delivery, overnight delivery with a reputable nationwide overnight delivery service, or certified mail (return receipt requested), and if given by personal delivery, shall be deemed delivered upon receipt; if given by overnight delivery, shall be deemed delivered one (1) day after deposit with a reputable nationwide overnight delivery service; and, if given by certified mail (return receipt requested), shall be deemed delivered two (2) days after the time the notifying party deposits the notice with the United States Postal Service. Any notices given pursuant to this Lease shall be addressed to Tenant at the Premises, or to Landlord or Tenant at the addresses shown in Sections 2.10 and 2.11 , respectively. Either party may, by notice to the other given pursuant to this Section, specify additional or different addresses for notice purposes.

40.13.       This Lease shall be governed by, construed and enforced in accordance with the laws of the State in which the Premises are located, without regard to such State’s conflict of law principles.

40.14.       That individual or those individuals signing this Lease guarantee, warrant and represent that said individual or individuals have the power, authority and legal capacity to sign this Lease on behalf of and to bind all entities, corporations, partnerships, limited liability companies, joint venturers or other organizations and entities on whose behalf said individual or individuals have signed.

40.15.       If not publicly available, Tenant agrees that it shall promptly furnish to Landlord, from time to time, upon Landlord’s written request, the most recent audited year-end financial statements reflecting Tenant’s current financial condition.  Tenant represents and warrants that all financial statements, records and information furnished by Tenant to Landlord in connection with this Lease are true, correct and complete in all respects.

40.16.       This Lease may be executed in one or more counterparts, each of which, when taken together, shall constitute one and the same document.

41.            Option to Extend Term . Tenant shall have the option (“ Option ”) to extend the Term of this Lease upon the following terms and conditions:

41.1.         Tenant shall have two (2) consecutive options to extend the Term of this Lease by five (5) years each (each, an “Extended Term” ) on the same terms and conditions as this Lease, except that the Monthly Base Rent payable under this Lease shall be 95% of the Fair Market Rental Value. “ Fair Market Rental Value ” shall mean the fair market value of laboratory/office space of similar age and finish in the Longmont, Colorado market taking into account all relevant factors, including without limitation, improvement allowances or rent concessions granted in connection with such other leases, provided, however, that in no event shall any leasehold improvement made by Tenant following the Commencement Date ever be considered in any valuation of the fair market value of the space.  The Basic Annual Rent of each Extended Term shall be subject to an annual upward adjustment of two percent (2%) of the then-current Basic Annual Rent.

41.2.         The Option is not assignable separate and apart from this Lease.

41.3.         The Option is conditional upon Tenant giving Landlord written notice of its election to exercise the Option at least twelve (12) months prior to the (i) expiration of the initial Term in the case of the first Extended Term, or (ii) expiration of the first Extended Term in the case of the second Extended Term.  If said notice is not delivered within said time period(s), the Option shall terminate.

41.4.         Within thirty (30) days after receiving Tenant’s notice extending the Term of this Lease pursuant to Section 41.3 above, Landlord shall provide Tenant with Landlord’s good faith estimate of 95% of the Fair Market Rental Value of the Premises for the Extended Term.  If Tenant is unwilling to accept Landlord’s estimate of the Fair Market Rental Value as set forth in Landlord’s notice referred to above, and the parties are unable to reach agreement thereon within thirty (30) days after the delivery of such notice by Landlord, then either party may obtain and

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deliver to the other party an independent appraisal of the Fair Market Rental Value of the Premises within ten (10) days after the expiration of such thirty (30) day period.  Within fifteen (15) days after receiving such party’s appraisal, the responding party may elect to obtain at its own expense and deliver to the initiating party a second independent appraisal of the Fair Market Rental Value of the Premises.  If the second appraiser shall not have been so appointed within such fifteen (15) day period, the Fair Market Rental Value of the Premises shall be determined by the initiating party’s appraisal. If the second appraiser shall have been so appointed, the two appraisers thus appointed shall, within fifteen (15) days after the responding party’s notice of appointment of the second appraiser, appoint a third appraiser.  If the two initial appraisers are unable timely to agree on the third appraiser, then either may, on behalf of both, request such appraiser by the Denver office of JAMS Inc., or its successor, or, on its failure, refusal or inability to act, by a court of competent jurisdiction.  Within fifteen (15) days after the appointment of the third appraiser, the Fair Market Rental Value of the Premises shall be the arithmetical average of the two appraisals closest in their determination of fair market rental value which amount shall be binding upon the parties.  All appraisers shall be qualified MAI appraisers who are independent from the parties and have had at least ten (10) years commercial real estate experience in the greater Denver area and significant experience dealing with the laboratory space sub-market.  Each party shall pay the fees of its own appraiser, and the fees of the third appraiser shall be shared equally by the parties.

41.5.         Notwithstanding anything contained in this Section 41 , Tenant shall not have the right to exercise the Option:

(a)            During the time commencing from the date Landlord delivers to Tenant a written notice that Tenant is in default under any provisions of this Lease and continuing until Tenant has cured the specified default to Landlord’s reasonable satisfaction; or

(b)            At any time after an event of Default as described in Section 23.4 of the Lease (provided, however, that, for purposes of this Subsection 41.5(b) , Landlord shall not be required to provide Tenant with notice of such Default) and continuing until Tenant cures any such Default, if such Default is susceptible to being cured; or

(c)            In the event that Tenant has defaulted in the performance of its obligations under this Lease three (3) or more times and a service or late charge has become payable under Section 23.1 for each of such defaults during the twelve (12)-month period immediately prior to the date that Tenant intends to exercise the Option, whether or not Tenant has cured such defaults.

41.6.         The period of time within which Tenant may exercise the Option shall not be extended or enlarged by reason of Tenant’s inability to exercise the Option because of the provisions of Section 41.4 .

41.7.         All of Tenant’s rights under the provisions of the Option shall terminate and be of no further force or effect even after Tenant’s due and timely exercise of an Option if, after such exercise, but prior to the commencement date of the new term, (a) Tenant fails to pay to Landlord a monetary obligation of Tenant for a period of twenty (20) days after written notice from Landlord to Tenant, (b) Tenant fails to commence to cure a default (other than a monetary default) within thirty (30) days after the date Landlord gives notice to Tenant of such default or (c) Tenant has defaulted under this Lease three (3) or more times and a service or late charge under Section 23.1 has become payable for any such default during the immediately preceding 24-month period, whether or not Tenant has cured such defaults.

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IN WITNESS WHEREOF, the parties hereto have executed this Lease as of the date first above written.

LANDLORD :

 

 

 

 

 

BMR-Trade Centre Avenue LLC,
a Delaware limited liability company

 

 

 

By:

BioMed Realty, L.P.,
a Maryland limited partnership,
its Member

 

 

 

 

 

 

 

 

 

Name:

 

 

Title:

 

 

 

 

 

 

TENANT :

 

 

 

 

 

Array BioPharm Inc.,
a Delaware corporation

 

 

 

 

By:

 

 

Name:

Mike Carruthers

 

 

Title:

  CFO  

 

 

 

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EXHIBIT A

PREMISES

Lots 1 and 2, St. Vrain Centre Parcel F-Minor Subdivision “C”, the Plat of which was recorded August 21, 1997 Reception No. 1724602 in Plan File P-40, F-3, No. 49, County of Boulder, State of Colorado.

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EXHIBIT B

ACKNOWLEDGEMENT OF TERM COMMENCEMENT DATE
AND TERM EXPIRATION DATE

THIS ACKNOWLEDGEMENT OF TERM COMMENCEMENT DATE AND TERM EXPIRATION DATE is entered into as of [       ], 2006, with reference to that certain Lease (the “ Lease ”) dated as of [       ], 2006 by Array BioPharma Inc., a Delaware corporation (“ Tenant ”), in favor of BMR-Trade Centre Avenue LLC, a Delaware limited liability company (“ Landlord ”). All capitalized terms used herein without definition shall have the meanings ascribed to them in the Lease.

Tenant hereby confirms the following:

1.                                        Tenant accepted possession of the Premises as-is on [       ], 20[  ].

2.                                        The Premises are in good order, condition and repair except as described on Exhibit    of the Lease.

3.                                        The Tenant Improvements required to be constructed by Landlord under the Lease have been substantially completed.

4.                                        All conditions of the Lease to be performed by Landlord as a condition to the full effectiveness of the Lease have been satisfied, and Landlord has fulfilled all of its duties in the nature of inducements offered to Tenant to lease the Premises.

5.                                        The Term Commencement Date is [       ], 2006, and, unless the Lease is terminated prior to the Term Expiration Date pursuant to its terms, the Lease Expiration Date shall be [       ], 2016.

6.                                        Tenant commenced occupancy of the Premises under this Lease for the Permitted Use on [       ], 20[  ].

7.                                        The Lease is in full force and effect, and the same represents the entire agreement between Landlord and Tenant concerning the Premises[, except [       ]].

8.                                        Tenant has no existing defenses against the enforcement of the Lease by Landlord, and there exist no offsets or credits against Rent owed or to be owed by Tenant.

9.                                        The obligation to pay Rent is presently in effect and all Rent obligations on the part of Tenant under the Lease commenced to accrue on [       ], 20[  ].

10.                                  The undersigned Tenant has not made any prior assignment, transfer, hypothecation or pledge of the Lease or of the rents thereunder or sublease of the Premises or any portion thereof.

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IN WITNESS WHEREOF, the parties hereto have executed this Acknowledgment of Term Commencement Date and Term Expiration Date as of [            ], 2016.

TENANT:

 

ARRAY BIOPHARMA INC,

a Delaware corporation

 

By:

 

 

Name:

 

 

Title:

 

 

 

2




EXHIBIT C

TENANT’S PERSONAL PROPERTY

Tenant’s Personal Property includes all non-attached furniture, fixtures and equipment.  In addition, for purposes of this Lease, “Tenant Personal Property” shall also include attached trade fixtures, equipment and improvements installed by Tenant prior to the Effective Date (the “Additional Tenant Property”). The Additional Tenant Property shall be transferred to and owned by Landlord at the end of the Lease Term.




EXHIBIT D

RULES AND REGULATIONS

NOTHING IN THESE RULES AND REGULATIONS (“ RULES AND REGULATIONS”) SHALL SUPPLANT ANY PROVISION OF THE LEASE. IN THE EVENT OF A CONFLICT OR INCONSISTENCY BETWEEN THESE RULES AND REGULATIONS AND THE LEASE, THE LEASE SHALL PREVAIL.

1.                                        Except as specifically provided in the Lease to which these Rules and Regulations are attached, no sign, placard, picture, advertisement, name or notice shall be installed or displayed on any part of the outside of the Premises or the Building without Landlord’s prior written consent. Landlord shall have the right to remove, at Tenant’s sole cost and expense and without notice, any sign installed or displayed in violation of this rule.

2.                                        Tenant shall not obstruct any sidewalks or entrances to the Building, or any halls, passages, exits, entrances or stairways within the Premises, in any case that are required to be kept clear for health and safety reasons.

3.                                        No deliveries shall be made that impede or interfere with operation of the Premises.

4.                                        Tenant shall not place a load upon any floor of the Premises that exceeds the load per square foot that (a) such floor was designed to carry or (b) that is allowed by Applicable Laws.

5.                                        Tenant shall not install any radio, television or other antenna, cell or other communications equipment, or any other devices on the roof or exterior walls of the Premises except to the extent shown on approved Tenant Improvements plans.  Tenant shall not interfere with radio, television or other communications from or in the Premises or elsewhere.

6.                                        Canvassing, peddling, soliciting and distributing handbills or any other written material within, on or around the Premises are prohibited, and Tenant shall cooperate to prevent such activities.

7.                                        Tenant shall store all of its trash, garbage and Hazardous Materials within its Premises or in designated receptacles outside of the Premises.  Tenant shall not place in any such receptacle any material that cannot be disposed of in the ordinary and customary manner of trash, garbage and Hazardous Materials disposal.

8.                                        The Premises shall not be used for any improper or illegal purpose.

9.                                        Tenant shall not, without Landlord’s prior written consent, use the name of the Premises, if any, in connection with or in promoting or advertising Tenant’s business except as Tenant’s address.

10.                                  Tenant shall comply with all safety, fire protection and evacuation procedures and regulations established by Landlord or any Governmental Authority.

11.                                  Tenant assumes any and all responsibility for protecting the Premises from theft, robbery and pilferage, which responsibility includes keeping doors locked and other means of entry to the Premises closed.

12.                                  Landlord may waive any one or more of these Rules and Regulations for the benefit of Tenant, but no such waiver by Landlord shall prevent Landlord from thereafter enforcing any such Rules and Regulations against Tenant.

13.                                  These Rules and Regulations are in addition to, and shall not be construed to in any way modify or amend, in whole or in part, the terms covenants, agreements and conditions of the Lease.

14.                                  Landlord reserves the right to make such other and reasonable rules and regulations as, in its judgment, may from time to time be needed for safety and security, the care and cleanliness of the Premises, or the preservation of good order therein; provided , however , that Landlord shall provide written notice to Tenant of such rules and regulations prior to them taking effect and these Rules and Regulations shall not materially interfere with Tenant’s use and quiet enjoyment




of the Premises.  Tenant agrees to abide by these Rules and Regulations and any additional rules and regulations issued or adopted by Landlord.

15.                                  Tenant shall be responsible for the observance of these Rules and Regulations by Tenant’s employees, agents, clients, customers, invitees and guests.




EXHIBIT E

FORM OF ESTOPPEL CERTIFICATE

To:                            BMR-Trade Centre Avenue LLC
17140 Bernardo Center Drive, Suite 222
San Diego, CA 92128
Attention: General Counsel

BioMed Realty, L.P.
c/o BioMed Realty Trust, Inc.
17140 Bernardo Center Drive, Suite 222
San Diego, CA 92128

Re:                                2600-2620 Trade Centre Avenue (the “ Premises ”) at 2600-2620 Trade Centre Avenue, Longmont, Colorado (the “ Property ”)

The undersigned tenant (“ Tenant ”) hereby certifies to you as follows:

1.                                        Tenant is a tenant at the Property under a lease (the “ Lease ”) for the Premises dated as of [       ], 20[  ]. The Lease has not been cancelled, modified, assigned, extended or amended [except as follows: [       ]], and there are no other agreements, written or oral, affecting or relating to Tenant’s lease of the Premises or any other space at the Property.  The lease term expires on [       ], 20[  ].

2.                                        Tenant took possession of the Premises, currently consisting of [       ] square feet, on [       ], 20[  ], and commenced to pay rent on [       ], 20[  ].  Tenant has full possession of the Premises, has not assigned the Lease or sublet any part of the Premises, and does not hold the Premises under an assignment or sublease[, except as follows:  [       ]].

3.                                        All base rent, rent escalations and additional rent under the Lease have been paid through [       ], 20[  ]. There is no prepaid rent[, except $[       ]][, and the amount of security deposit is $[       ] [in cash][in the form of a letter of credit]].  Tenant currently has no right to any future rent abatement under the Lease.

4.                                        Base rent is currently payable in the amount of $[       ] per month.

5.                                        Tenant is currently paying estimated payments of additional rent of $[       ] per month on account of real estate taxes, insurance, management fees and common area maintenance expenses.

6.                                        All work to be performed for Tenant under the Lease has been performed as required under the Lease and has been accepted by Tenant[, except [       ]], and all allowances to be paid to Tenant, including allowances for tenant improvements, moving expenses or other items, have been paid.

7.                                        The Lease is in full force and effect, free from default and free from any event that could become a default under the Lease, and Tenant has no claims against the landlord or offsets or defenses against rent, and there are no disputes with the landlord. Tenant has received no notice of prior sale, transfer, assignment, hypothecation or pledge of the Lease or of the rents payable thereunder[, except [       ]].

8.                                        [Tenant has the following expansion rights or options for the Property: [       ].][Tenant has no rights or options to purchase the Property.]

9.                                        To Tenant’s knowledge, no hazardous wastes have been generated, treated, stored or disposed of by or on behalf of the Tenant in, on or around the Premises in violation of any environmental laws.

10.                                  The undersigned has executed this Estoppel Certificate with the knowledge and understanding that BMR-Trade Centre Avenue LLC or its assignee is acquiring the Property in reliance on this certificate and that the undersigned shall be bound by this certificate.  The statements contained herein may be relied upon by BMR-Trade Centre Avenue LLC, BioMed




Realty, L.P., BioMed Realty Trust, Inc., and any mortgagee of the Property and their respective successors and assigns.

Any capitalized terms not defined herein shall have the respective meanings given in the Lease.

Dated this [    ] day of [       ], 20[  ].

[       ],

a [       ]

By:

 

 

Name:

 

 

Title:

 

 

 




EXHIBIT F

NONFUNCTIONAL EQUIPMENT

NONE.

F- 1



Exhibit 10.3

AGREEMENT OF PURCHASE AND SALE
( 2600 and 2620 Trade Centre Avenue, Longmont, Colorado )

This Agreement of Purchase and Sale (“ Agreement ”) is made as of the 9th day of August, 2006 (“ Effective Date ”) between Circle Capital Longmont LLC, a Delaware limited liability company (“ Seller ”), and Array BioPharma Inc., a Delaware corporation (“ Purchaser ”).

Seller’s predecessor in interest and Purchaser entered into a written lease agreement, dated February 28, 2000, as amended by Addendum to Lease Agreement #1 dated May 24, 2001, Addendum to Lease Agreement #2, dated February 11, 2002, Addendum to Lease Agreement dated November 30, 2004, Addendum #4 to Lease Agreement dated August 1, 2005 (“ Addendum #4 to 2620 Lease ”), Addendum #5 to Lease Agreement dated as of November 30, 2005, Addendum #6 to Lease Agreement dated December 22, 2005, Addendum #7 to Lease Agreement dated February 28, 2006, and Addendum #8 to Lease Agreement dated as of March 1, 2006 (collectively, the “ 2620 Lease ”), pertaining to an approximately 43,200 square foot building located at 2620 Trade Centre Avenue, Longmont, Colorado (“ 2620 Building ”).

Seller’s predecessor in interest and Purchaser entered into a written lease agreement, dated February 11, 2002, as amended by Addendum #1 to Lease Agreement dated November 30, 2004, and Addendum to Lease Agreement #2, dated August 4, 2005 (collectively, the “ 2600 Lease ”), pertaining to an approximately 28,800 square foot building located at 2600 Trade Centre Avenue, Longmont, Colorado (“ 2600 Building ”).

The 2620 Lease and the 2600 Lease shall be collectively referred to hereinafter as the “ Leases ”.

The 2620 Building and the 2600 Building shall be collectively referred to hereinafter as the “ Buildings ”.

Under Addendum #4 to 2620 Lease, Purchaser was granted an option, under certain terms, to purchase the Buildings (the “ Purchase Option ”).

Purchaser has notified Seller of its desire to purchase the Buildings from Seller.  Subject to the terms and conditions of this Agreement, Seller will sell to Purchaser, and Purchaser will purchase from Seller, the Property (as defined below), including the Buildings.

ARTICLE 1.                              PROPERTY/PURCHASE PRICE

1.1.                               Property .  Subject to the terms and conditions of this Agreement, Seller agrees to sell to Purchaser, and Purchaser agrees to purchase from Seller, the following property (collectively, the “ Property ”):

(a)                                   The “ Real Property ,” being the land described in Exhibit A attached hereto, the Building, all improvements and fixtures (other than fixtures owned by Purchaser pursuant to the Leases) located thereon (the “ Improvements ”); all and singular the rights, benefits, privileges, easements, tenements, hereditaments, and appurtenances thereon or in




anyway appertaining to such real property; and all right, title, and interest of Seller in and to all strips and gores and any land lying in the bed of any street, road or alley, open or proposed, adjoining such real property; and

(b)                               The “ Intangible Property ,” being all, right, title and interest of Seller, if any, in and to all intangible personal property now or hereafter used exclusively in connection with the operation, ownership, maintenance, management, or occupancy of the Real Property (to the extent assignable); the plans and specifications for the Improvements (to the extent assignable); warranties, indemnities, applications, permits, approvals and licenses (to the extent applicable in any way to the above referenced Real Property and assignable).

1.2.                               Purchase Price .  The total purchase price to be paid to Seller by Purchaser for the Property shall be Six Million Seven Hundred Eighty-Six Thousand Dollars ($6,786,000) (the “ Purchase Price ”).  The Purchase Price, as adjusted for prorations, deposits and other adjustments as provided herein, shall be paid to Escrow Agent by wire transfer of immediately available funds or in cash.

1.3.                               Title Company and Escrow Agent .  The “ Escrow Agent ” and “ Title Company ” is:  LandAmerica Commercial Services, 750 B. Street, Suite 3000, San Diego California 92101, Attn:  Katherine I. Leicht (Tel#: (619) 230-6346; Fax#: (619) 233-0369).

1.4.                               Closing Date .  The “ Closing Date ” shall mean 12:00 noon (MDT) on August 9, 2006.

ARTICLE 2.                              INSPECTION

2.1.                               Access .  Upon reasonable prior notice to Seller, Purchaser and its agents, employees, consultants, lenders and representatives shall have reasonable access to the Property and all books and records for the Property that are located at the property manager’s offices located at:  1375 Ken Pratt Boulevard, Suite C, Longmont, CO 80501 (“ Manager’s Office ”), for the purpose of conducting surveys, appraisals, architectural, engineering, structural, mechanical, geotechnical and environmental inspections and tests, and any other inspections, studies, or tests reasonably required by Purchaser; provided, however, Purchaser may not conduct any invasive testing without Seller’s prior consent (which consent shall be at Seller’s sole discretion).  If any inspection or test disturbs the Property in a material respect, Purchaser will restore the Property to its condition before any such inspection or test.  During the pendency of this Agreement, Purchaser and its agents, employees, consultants, lenders and representatives shall have a continuing right of reasonable access to the Property and the Manager’s Office, with reasonable prior notice, for the purpose of examining and making copies of all books and records and other materials relating to the Property.  In the course of its investigations, Purchaser may make reasonable inquiries to third parties, including, without limitation, representatives, contractors, property managers and municipal, local and other government officials and representatives in accordance with the terms of this Agreement, and Seller consents to such inquiries.  Purchaser hereby indemnifies, protects, defends (with counsel reasonably acceptable to Seller) and holds Seller and the Property free and harmless from and against any and all costs, losses, liabilities, damages, lawsuits, judgments, actions, proceedings, penalties, demands, attorneys’ fees, mechanic’s liens, or expenses of any kind or nature whatsoever (“ Claims ”), to the extent caused

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by any entry and/or activities upon the Property by Purchaser, Purchaser’s agents, contractors and/or subcontractors; provided, however, Purchaser shall not indemnify Seller against any Claims caused by Seller’s gross negligence or willful misconduct.

2.2                               Service Contracts; Property Management and Leasing Agreements; Property Employees .  Seller shall terminate at Closing, and Purchaser shall not assume, any property management or third party leasing agreements affecting the Property.  Seller and Purchaser hereby agree and acknowledge that Seller currently has contracts with the following service providers at the Property:  (i) SureLockPlus (Fire Alarm Monitoring); (ii) MaiCon (Parking Lot Lighting); (iii) Window King (Window washing); (iv) Longmont Sweeping (Parking lot sweeping); and (v) CoCal Landscape (Grounds Maintenance) (collectively, the “Service Contracts”).  Seller shall amend or terminate the Service Contracts such that the Service contracts do not affect the Property on August 31, 2006.  Until such time as the Service Contracts are appropriately amended or terminated, Seller shall arrange to have the service providers maintain the Property in accordance with the terms of the Service Contracts and, upon request of Purchaser, enforce the Service Contracts for the benefit of Purchaser with respect to the Property.  Seller shall have no liability for any acts or omission of the service providers under the Service Contracts.  Seller hereby acknowledges that Purchaser paid for its proportionate share of the amounts due under the Service Contracts through August 31, 2006, along with Purchaser’s August rent payments under the Leases. All amounts paid by Purchaser to Seller under the Leases and allocated to the Service Contracts shall be final and shall not be pro-rated at Closing.  The provisions of this Paragraph 2.2 shall survive Closing.

ARTICLE 3.                              TITLE AND SURVEY REVIEW

3.1.                               Delivery of Preliminary Title Report and Survey .  Seller shall cause to be delivered to Purchaser on or prior to the date that is five (5) days after the Effective Date, any existing survey of the Property in Seller’s possession or control (the “ Survey ”).  Purchaser may update the Survey, at Purchaser’s sole discretion.  Purchaser has obtained a commitment to insure title to the Property (the “ Title Commitment ”) issued by the Title Company together with copies of the items listed on Scheduled B-2 (the “ Exception Documents ”).  The Title Commitment, Exception Documents, and the Survey are referred to herein collectively as the “ Title Documents .”

3.2.                               Title Review and Cure .  Prior to the Closing Date, Purchaser shall review title to the Property as disclosed by the Title Documents.

3.3.                               Permitted Exceptions .  “ Permitted Exceptions ” means the following exceptions approved or deemed approved by Purchaser pursuant to this Agreement:  (i) real property taxes and assessments for the calendar year of the Closing (as defined below) and subsequent years; (ii) any taxes, assessments, fees or charges by reason of the inclusion of the Property in any statutory district of record; (iii) covenants, as amended and supplemented, of record; (iv) utility, landscape and drainage easements of record; (v) any covenants contained in the applicable subdivision plat; (vi) applicable zoning and building code laws and regulations; (vii) liens and encumbrances created by, through or under Purchaser; (viii) all matters disclosed by the Survey

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or would be disclosed by an update thereto; and (ix) the Leases, unless otherwise terminated pursuant to the terms contained herein.

ARTICLE 4.                              OPERATIONS

4.1.                               Ongoing Operations .  During the pendency of this Agreement:

(a)                                Preservation of Business .  Seller shall cause the Property to be operated in a manner consistent with the terms and conditions of the Leases.

(b)                               Maintenance of Insurance .  Seller shall continue to carry its existing insurance as required by the Leases through the Closing Date.

(c)                                New Contracts .  Without Purchaser’s prior written consent in each instance, Seller will not enter into or amend, terminate, waive any default under, or grant concessions regarding any contract or agreement that will be an obligation affecting the Property or binding on Purchaser after the Closing.

(d)                               Leasing Arrangements .  Seller will not enter into any new lease or other occupancy agreement affecting the Improvements without Purchaser’s prior written consent in each instance.

(e)                                Maintenance of Permits .  Seller shall maintain in existence all licenses, permits and approvals, if any, in accordance with past business practices.

ARTICLE 5.                              CONDITIONS PRECEDENT

5.1.                               Conditions to Seller’s Obligation to Close .  In addition to all other conditions set forth herein, the obligation of Seller to consummate the transactions contemplated hereunder shall be contingent upon the following:

(a)                                Representations .  Purchaser’s representations and warranties contained herein shall be true and correct as of the date of this Agreement and the Closing Date;

(b)                               Performance .  As of the Closing Date, Purchaser shall have performed its obligations hereunder and all deliveries to be made by Purchaser at Closing have been tendered;

(c)                                Other Condition .  Any other condition set forth in this Agreement to Seller’s obligation to close shall have been satisfied by the applicable date; and

(d)                               Leases .  There shall have been no material Events of Default by Purchaser under the Leases, which have not been remedied by Purchaser as of the Closing Date.

5.2.                               Conditions to Purchaser’s Obligation to Close .  In addition to all other conditions set forth herein, the obligation of Purchaser to consummate the transactions contemplated hereunder shall be contingent upon the following:

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(a)                                Representations .  Seller’s representations and warranties contained herein shall be true and correct as of the date of this Agreement and the Closing Date;

(b)                               Deliveries .  All deliveries to be made by Seller at Closing have been tendered;

(c)                                Bankruptcy .  No proceeding has been commenced against Seller under the federal Bankruptcy Code or any state law for relief of debtors; and

(d)                               Title .  At Closing, the Title Company shall irrevocably commit to issue to Purchaser an ALTA Owner’s Policy of title insurance, dated as of the date and time of the recording of the Deed (as defined below), vesting title in Purchaser, in the amount of the Purchase Price (the “ Title Policy ”).

5.3                               Termination of Leases/Expansion Option .  Effective as of Closing, the Leases, including any “Expansion Option” thereunder (as defined in Addendum #4 of the 2620 Lease), shall terminate and the parties shall execute a termination of the Leases in a form reasonably acceptable to Seller and Purchaser.  Purchaser and Seller agree that neither party shall have any obligation under, or take any further action with respect to, the Expansion Option from the Effective Date of this Agreement until the Closing Date and that all applicable time periods for giving notice under Section 10 of Addendum #4 of the 2620 Lease shall be tolled from the Effective Date until the Closing Date.

ARTICLE 6.                              DEFAULT AND REMEDIES

6.1.                               Purchaser’s Defaults; Seller’s Remedies .  In the event of a material breach by Purchaser of its obligations under this Agreement, Seller shall have the right of specific performance and additional actual damages.

6.2.                               Seller’s Defaults; Purchaser’s Remedies .  In the event of a material breach by Seller of its obligations under this Agreement, Purchaser shall have the right of specific performance and additional actual damages.

ARTICLE 7.                              CLOSING

7.1.                               Closing and Escrow .  The consummation of the transaction contemplated herein (“ Closing ”) shall occur on the Closing Date at the offices of the Escrow Agent.  Closing shall occur through an escrow with the Escrow Agent.  Funds shall be deposited into and held by Escrow Agent in a closing escrow account with a bank satisfactory to Purchaser and Seller.  Upon satisfaction or completion of all closing conditions and deliveries, Escrow Agent shall record and deliver the Deed (as defined below) and deliver the closing document s to the appropriate parties and make disbursements according to the closing statements executed by Seller and Purchaser.  Provided such supplemental escrow instructions are not in conflict with this Agreement as it may be amended in writing from time to time, Seller and Purchaser agree to execute such supplemental escrow instructions as may be appropriate to enable Escrow Agent to comply with the terms of this Agreement.  The parties understand that the Closing shall occur in

5




Longmont, Colorado and that all necessary deliveries to escrow must be completed by 11:00 A.M. on the Closing Date.

7.2.                               Seller’s Deliveries in Escrow .  On or before 11:00 A.M. on the Closing Date, Seller shall deliver in escrow to the Escrow Agent the following:

(a)                                Deed .  That certain special warranty deed (“ Deed ”) in the form attached as Exhibit C hereto sufficient to vest title in Purchaser, subject only to the Permitted Exceptions;

(b)                               Bill of Sale .  A Bill of Sale (“ Bill of Sale ”) executed and acknowledged by Seller in the form attached as Exhibit D hereto;

(c)                                State Law Disclosures .  Such disclosures and reports as are required by applicable state and local law in connection with the conveyance of real property;

(d)                               FIRPTA .  A Foreign Investment in Real Property Tax Act affidavit executed by Seller;

(e)                                Authority .  Evidence of the existence, organization and authority of Seller and of the authority of the persons executing documents on behalf of Seller required by and reasonably satisfactory to the Title Company;

(f)                                  Owner’s Affidavit .  An Owner’s Affidavit, if required, in the form attached as Exhibit E hereto; and

(g)                               Other Deliveries .  Any other Closing deliveries required to be made by or on behalf of Seller hereunder or reasonably required by the Title Company to effect the Closing of this transaction consistent with this Agreement.

7.3.                               Purchaser’s Deliveries in Escrow .  On or before 9:00 a.m. on the Closing Date, Purchaser shall deliver in escrow to the Escrow Agent the following:

(a)                                Purchase Price .  The Purchase Price, plus or minus applicable prorations, deposited by Purchaser with the Escrow Agent in immediate, same-day federal funds wired for credit into the Escrow Agent’s escrow account;

(b)                               Bill of Sale .  Counterpart of the Bill of Sale, executed by Purchaser;

(c)                                State Law Disclosures .  Such disclosures and reports as are required by applicable state and local law in connection with the conveyance of real property; and

(d)                               Other Deliveries .  Any other Closing deliveries required to be made by or on behalf of Purchaser hereunder or reasonably required to effect the Closing of this transaction consistent with this Agreement.

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7.4.                               Closing Statements/Closing Costs .

(a)                                Seller and Purchaser shall deposit with the Escrow Agent executed closing statements consistent with this Agreement in the form required by the Escrow Agent.

(b)                               Seller and Purchaser shall execute such returns, questionnaires and other documents as shall be required with regard to all applicable real property transaction taxes imposed by applicable federal, state or local law or ordinance.

(c)                                Seller shall pay the fees of any counsel representing Seller in connection with this transaction.  Seller shall also pay the following costs and expenses:

(i)                                   one-half of the closing and escrow fees, if any, which may be charged by the Escrow Agent or the Title Company;

(ii)                                   one-half of the owner’s title insurance premium for the Title Policy, excluding any endorsements Purchaser wishes to purchase from Title Company;

(iii)                                one-half of the cost of an updated Survey;

(iv)                               one-half of all of the recording fees; and

(v)                               a brokerage commission due to CRESA Partners in an amount equal to Eighty-One Thousand Four Hundred Thirty-Two Dollars ($81,432)(“ Broker’s Commission ”), which represents 3% of the applicable purchase price of the 2600 Building.  The parties, including CRESA Partners, acknowledge and represent that CRESA Partners is acting as Purchaser’s broker in this transaction and Seller owes only the Broker’s Commission as set forth above, and no other amount are due and owing to CRESA Partners by Seller or its predecessors under the Leases or as a result of the transaction under this Agreement.  Seller and Purchaser represent and warrant each to the other that they have not dealt with any real estate broker, sales person or finder, other than CRESA Partners, in connection with this transaction.  Other than the payment provided to CRESA Partners as provided in this Section 7.4(c)(v), each shall indemnify and hold harmless the other party from and against any claim for broker’s or finder’s fees or commissions arising under such party in connection with the negotiation, execution or consummation of this Agreement or the transactions contemplated hereby.

(d)                               Purchaser shall pay the fees of any counsel representing Purchaser in connection with this transaction.  Purchaser shall also pay the following costs and expenses:

(i)                                   one-half of the closing and escrow fees, if any, which may be charged by the Escrow Agent or the Title Company; and

(ii)                                   one-half of the owner’s title insurance premium for the Title Policy and all fees charged for any endorsements the Purchaser wishes to purchase from the Title Company;

(iii)                                one-half of the cost of an updated Survey; and

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(iv)                               one-half of the recording fees.

7.5.                               Possession .  At the time of Closing, Seller shall deliver to Purchaser possession of the Property, subject only to the Permitted Exceptions.

ARTICLE 8.                              PRORATIONS AND ADJUSTMENTS

8.1.                               Prorations .  The items in Subsections (a) through (c) of this Section 8.1 shall be prorated between Seller and Purchaser, based on the actual number of days in the applicable period, as of the close of the day immediately preceding the Closing Date, the Closing Date being a day of income and expense to Purchaser:

(a)                                Income .  Seller shall have a right to receive the base rent under the Leases, together with all amounts of additional rent attributable to the period prior to the Closing Date.  Purchaser shall receive a credit for any base rent or additional rent, under the Leases collected by Seller before Closing that applies to any period after Closing Date.

(b)                               Taxes .  Purchaser shall be solely responsible for all property taxes due at Closing and thereafter.

(c)                                Other Expenses .  Seller or Purchaser, as the case may be, shall receive a credit for all other charges, including, without limitation, insurance, maintenance and other operating costs and expenses, paid and applicable to Purchaser’s period of ownership or payable and applicable to Seller’s period of ownership, respectively.

(d)                               Tenant Improvements and Leasing Commissions .  At Closing, Purchaser will pay Seller, in addition to the Purchase Price, an additional amount equal to the unamortized component of any tenant improvements or lease commission costs incurred by Seller for leasing the Property to Purchaser.  Seller and Purchaser acknowledge and agree that, provided that the Closing occurs on August 9, 2006, the amount owed to Seller under this Section 8.1(d) shall be Two Hundred Thirteen Thousand Seven Hundred Seventy-Three and 20/100 Dollars ($213,773.20).

(e)                                Broker’s Credit to Purchaser .  At Closing, Purchaser shall receive a credit in an amount equal to One Hundred Twenty-Two Thousand One Hundred Forty-Eight Dollars ($122,148), which represents 3% of the applicable purchase price of the 2620 Building.  This credit representing the co-operative broker’s commission that Seller would have otherwise paid to Purchaser’s broker in connection with the 2620 Building.  In accordance with § 7.4(c)(v) Purchaser represents that Seller is not obligated to pay any such broker’s commissions.

ARTICLE 9.                              REPRESENTATIONS AND WARRANTIES

9.1.                               Seller’s Representations and Warranties .  As a material inducement to Purchaser to execute this Agreement and consummate this transaction, Seller represents and warrants to Purchaser that:

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(a)                                Organization and Authority .  Seller has been duly organized, is validly existing, and is in good standing as a Delaware limited liability company.  Seller is in good standing and is qualified to do business in the state in which the Real Property is located.  Seller has the full right and authority and has obtained any and all consents required to enter into this Agreement and to consummate or cause to be consummated the transactions contemplated hereby.  This Agreement has been, and all of the documents to be delivered by Seller at the Closing will be, authorized and properly executed and constitute, or will constitute, as appropriate, the valid and binding obligations of Seller, enforceable in accordance with their terms.

9.2.                               Purchaser’s Representations and Warranties .  As a material inducement to Seller to execute this Agreement and consummate this transaction, Purchaser represents and warrants to Seller that:

(a)                                Organization and Authority .  Purchaser has been duly organized and is validly existing as a Delaware corporation, in good standing and will be qualified to do business in the state in which the Real Property is located on the Closing Date.  Purchaser has the full right and authority and has obtained any and all consents required to enter into this Agreement and to consummate or cause to be consummated the transactions contemplated hereby.  This Agreement has been, and all of the documents to be delivered by Purchaser at the Closing will be, authorized and properly executed and constitutes, or will constitute, as appropriate, the valid and binding obligation of Purchaser, enforceable in accordance with their terms.

(b)                               Conflicts and Pending Action .  There is no agreement to which Purchaser is a party or to Purchaser’s knowledge binding on Purchaser which is in conflict with this Agreement.  There is no action or proceeding pending or, to Purchaser’s knowledge, threatened against Purchaser which challenges or impairs Purchaser’s ability to execute or perform its obligations under this Agreement.

(c)                                “As-Is” Purchase .  Except for the warranties of title set forth in the Deed, the sale of the Property to Purchaser shall be on an “ AS IS ” basis, it being understood that Purchaser will have had an opportunity to investigate the Property and all matters relevant to its acquisition, development, usage, operation or marketability, including (without limitation) environmental assessments of the Property, at Purchaser’s sole expense, including but not limited to, the collection and analysis of soils, surface water and groundwater samples.  At Closing, Purchaser, as purchaser for itself and on behalf of its officers, directors, shareholders, employees, heirs, successors, assigns, parents, subsidiaries, affiliates and agents representatives (hereinafter referred to as “ Releasing Parties ”) unconditionally releases Seller, its officers, directors, shareholders, employees, heirs successors, assigns, parents, subsidiaries, affiliates, agents and representatives from and against any and all liability to the Releasing Parties, both known and unknown, past, present and future, for any damages, costs, expenses or other liability to the Releasing Parties arising out of any violation of environmental requirements, environmental laws or governmental regulations, or the presence of regulated substances, hazardous materials or hazardous substances on, under, about or migrating to or from the Property, whether occurring before, during or after Purchaser’s acquisition of the Property (the “ Condition of the Property ”).  This release shall survive the Closing and remain in effect indefinitely.  Purchaser, as purchaser,

9




shall indemnify, defend with counsel reasonably acceptable to Seller and hold Seller harmless from any and all claims of any kind or nature (including, without limitation, diminution in value), demands, liabilities, liens, losses, damages, costs and expenses (including, without limitation, fines, forfeitures, attorneys’ fees, disbursements and court and/or administrative costs) asserted against Seller or the Property arising out of or resulting from the Condition of the Property.

ARTICLE 10.                                                                       MISCELLANEOUS

10.1.                         Parties Bound .  Neither party may assign this Agreement without the prior written consent of the other, and any such prohibited assignment shall be void; provided, however, that Purchaser may assign this Agreement without Seller’s consent, upon prior notice to Seller given prior to Closing, to BioMed Realty, L.P. (“ BioMed ”) or an Affiliate of BioMed (including without limitation BioMed Realty Trust, Inc. or BMR-Trade Centre Avenue LLC).  Subject to the foregoing, this Agreement shall be binding upon and inure to the benefit of the respective legal representatives, successors, assigns, heirs, and devisees of the parties.  For the purposes of this paragraph, the term “ Affiliate ” means (i) an entity that directly or indirectly controls, is controlled by or is under common control with BioMed, or (ii) a partnership or other entity in which BioMed or an entity described in (i) is a partner or other owner; and the term “control” means the power to direct the management of such entity through voting rights, ownership or contractual obligations.  Notwithstanding the foregoing, Purchaser shall not be released from its obligations hereunder upon an assignment to BioMed, an Affiliate of BioMed, or any other approved assignment.

10.2.                         Headings .  The article and paragraph headings of this Agreement are for convenience only and in no way limit or enlarge the scope or meaning of the language hereof.

10.3.                         Expenses .  Except as otherwise expressly provided herein, each party hereto shall pay its own expenses incident to this Agreement and the transactions contemplated hereunder, including all legal and accounting fees and disbursements.

10.4.                         Invalidity and Waiver .  If any portion of this Agreement is held invalid or inoperative, then so far as is reasonable and possible the remainder of this Agreement shall be deemed valid and operative, and, to the greatest extent legally possible, effect shall be given to the intent manifested by the portion held invalid or inoperative.  The failure by either party to enforce against the other any term or provision of this Agreement shall not be deemed to be a waiver of such party’s right to enforce against the other party the same or any other such term or provision in the future.

10.5.                         Governing Law .  This Agreement shall, in all respects, be governed, construed, applied, and enforced in accordance with the law of the state in which the Real Property is located.

10.6.                         Survival .  The provisions of this Agreement and the obligations of the parties not fully performed at the Closing shall survive the Closing for one year and shall not be deemed to be merged into or waived by the instruments of Closing.  Any claim for performance of an

10




obligation after Closing shall be barred and shall lapse unless a claim is made in writing, with a description of the claim made, on or before six months from the Closing Date.

10.7.                         No Third Party Beneficiary .  This Agreement is not intended to give or confer any benefits, rights, privileges, claims, actions, or remedies to any person or entity as a third party beneficiary, decree, or otherwise.

10.8.                         Entirety and Amendments .  This Agreement embodies the entire agreement between the parties and supersedes all prior agreements and understandings relating to the Property.  This Agreement may be amended or supplemented only in writing by a non-electronic instrument executed by the party against whom enforcement is sought.  For the avoidance of doubt, copies of signed instruments that are electronically transmitted constitute a writing for this purpose.

10.9.                         Time of the Essence .  Time is of the essence in the performance of this Agreement.

10.10.                   Time .  All times, whenever specified herein, shall be local time in Longmont, Colorado.

10.11.                   Confidentiality .  Subject to Section 10.12 , Seller and Buyer agrees to keep all negotiations and the terms of this Agreement confidential, and shall not disclose such terms to any person, without the prior written approval of the other party.

10.12.                   Press Release .  Until the Closing. neither Seller nor Purchaser will release or cause or permit to be released any press notices, or publicity (oral or written) or advertising promotion relating to, or otherwise announce or disclose or cause or permit to be announced or disclosed, in any manner whatsoever, the terms, conditions or substance of this Agreement without first obtaining the written consent of the other party except those disclosures that are required by law, including the Securities Act of 1933 (in which case notice shall be timely provided to the other party of such requirement and disclosure).  The foregoing shall not preclude either party from discussing the substance or any relevant details of such transactions with any of its attorneys, accountants, professional consultants, lenders, partners, investors, or any prospective lender, partner or investor, as the case may be, or prevent either party hereto, from complying with laws, rules, regulations and court orders, including without limitation, governmental regulatory, disclosure, tax and reporting requirements, or from making disclosures in the ordinary course of its due diligence inspections and contacts with third parties related thereto.  Notwithstanding the foregoing, any party to this transaction (and each employee, agent or representative of the foregoing) may disclose to any and all persons, without limitation of any kind, the tax treatment and tax structure of the transaction and all materials of any kind (including opinions or other tax analyses) that are provided to them relating to such tax treatment and tax structure except to the extent maintaining such confidentiality is necessary to comply with any applicable federal or state securities laws.  The authorization in the preceding sentence is not intended to permit disclosure of any other information unrelated to the tax treatment and tax structure of the transaction including (without limitation) (i) any portion of the transaction documents or related materials to the extent not related to the tax treatment or tax structure of the

11




transaction, (ii) the existence or status of any negotiations unrelated to the tax issues, or (iii) any other term or detail not relevant to the tax treatment or the tax structure of the transaction.

Notwithstanding the foregoing, in no event shall Purchaser or its employees, agents successors or assigns disclose the identity of and any information related to any of the members or investors in Seller, either before or after the Closing.

10.13.                   Attorneys’ Fees .  Should either party employ attorneys to enforce any of the provisions hereof, the non-prevailing party agrees to pay the prevailing party all reasonable costs, charges, and expenses, including reasonable attorneys’ fees, expended or incurred by the prevailing party in connection therewith, whether incurred prior to, during or subsequent to any bankruptcy, receivership, reorganization, appellate, or other legal proceeding.

10.14.                   Notices .  All notices required or permitted hereunder shall be in writing and shall be served on the parties at the addresses set forth in Exhibit B .  Any such notices shall be either (i) sent by overnight delivery using a nationally recognized overnight courier, in which case notice shall be deemed delivered one business day after deposit with such courier, (ii) sent by facsimile on a business day, in which case notice shall be deemed delivered upon transmission of such notice with confirmed receipt by the sender’s machine, or (iii) sent by personal delivery, in which case notice shall be deemed delivered upon receipt or refusal of delivery.  A party’s address may be changed by written notice to the other party; provided, however, that no notice of a change of address shall be effective until actual receipt of such notice.  Copies of notices are for informational purposes only, and a failure to give or receive copies of any notice shall not be deemed a failure to give notice.  The attorney for a party has the authority to send notices on behalf of such party.

10.15.                   Construction .  The parties acknowledge that the parties and their counsel have reviewed and revised this Agreement and that the normal rule of construction to the effect that any ambiguities are to be resolved against the drafting party shall not be employed in the interpretation of this Agreement or any exhibits or amendments hereto.

10.16.                   Remedies Cumulative .  Except as expressly provided to the contrary in this Agreement, the remedies provided in this Agreement shall be cumulative and shall not preclude the assertion or exercise of any other rights or remedies available by law, in equity or otherwise.

10.17.                   Calculation of Time Periods .  Unless otherwise specified, in computing any period of time described herein, the day of the act or event after which the designated period of time begins to run is not to be included and the last day of the period so computed is to be included, unless such last day is a Saturday, Sunday or legal holiday for national banks in the location where the Property is located, in which event the period shall run until the end of the next day which is neither a Saturday, Sunday, or legal holiday.  The last day of any period of time described herein and the time during any day by which an event must occur shall be deemed to end at 5 p.m.

10.18.                   Public Company Requirements .  Upon Purchaser’s request, for a period of two (2) years after Closing, Seller shall make any books and records of the Property remaining in possession of Seller available to Purchaser for inspection, copying and audit by Purchaser’s

12




designated accountants, and at Purchaser’s expense (exclusive of records pertaining to the entity owning the Property, appraisals and other documents Seller deems confidential).  Seller shall make available to Purchaser, but without third-party expense to or warranty by Seller, such factual information in connection with this Agreement and/or the Property as may be reasonably requested by Purchaser, and in the possession or control of Seller, to enable Purchaser to comply with applicable filing requirements of the Securities and Exchange Commission.  Purchaser or its designated independent or other accountants may audit the operating statements of the Property, and Seller shall supply such documentation in its possession or control as Purchaser or its accountants may reasonably request in order to complete such audit.

10.19.                   Execution in Counterparts .  This Agreement may be executed in any number of counterparts, each of which shall be deemed to be an original, and all of such counterparts shall constitute one agreement.  To facilitate execution of this Agreement, the parties may execute and exchange by telephone facsimile counterparts of the signature pages.

10.20.                   Further Assurances .  In addition to the acts and deeds recited herein and contemplated to be performed, executed or delivered by either party at Closing, each party agrees to perform, execute and deliver, on or after the Closing any further actions, documents, and will obtain such consents, as may be reasonably necessary or as may be reasonably requested to fully effectuate the purposes, terms and conditions of this Agreement or to further perfect the conveyance, transfer and assignment of the Property to Purchaser.

10.21.                   Approval .  To the extent any approval or consent shall be required in this Agreement such approval or consent shall not be unreasonably withheld, unless the terms of and conditions of such approval or consent are to the sole discretion of such party.

10.22.                   Waiver of Jury Trial .  TO THE EXTENT PERMITTED BY APPLICABLE LAW, THE PARTIES HEREBY IRREVOCABLY WAIVE ANY AND ALL RIGHT TO TRIAL BY JURY IN ANY LEGAL PROCEEDING ARISING OUT OF OR RELATING TO THIS AGREEMENT, OR THE TRANSACTIONS CONTEMPLATED HEREBY.

13




IN WITNESS WHEREOF, the parties hereto have executed this Agreement, as of the Effective Date.

 

SELLER:

 

 

 

CIRCLE CAPITAL LONGMONT LLC,
a Delaware limited liability company

 

 

 

By:

Longmont Senior Mezzanine Owner LLC,
a Delaware limited liability company, its
Sole Member and Manager

 

 

 

 

 

By:

Longmont Junior Mezzanine Owner LLC,
a Delaware limited liability company, its
Sole Member and Manager

 

 

 

 

 

 

By:

Circle Longmont Limited Partnership,
a Delaware limited partnership, its
Sole Member and Manager

 

 

 

 

 

 

By:

Circle Capital Longmont GP
LLC, a Colorado limited
liability company, its General
Partner

 

 

 

 

 

 

By:

 

 

 

Name:

 

 

 

Title:

 

 

 

 

PURCHASER:

 

 

 

ARRAY BIOPHARMA INC. ,
a Delaware corporation

 

 

 

 

 

By:

/s/ Mike Carruthers

 

Name:

Mike Carruthers

 

Title:

 

 

Acknowledged and agreed as to Section 8.1(f)

CRESA Partners

 

 

 

By:                                         , its                           

 

 

14




EXHIBIT A

LEGAL DESCRIPTION OF REAL PROPERTY

LOTS 1 AND 2, ST. VRAIN CENTRE PARCEL F – MINOR SUBDIVISION “C”, ACCORDING TO THE PLAT THEREOF RECORDED AUGUST 21, 1997 UNDER RECEPTION NO. 1724602, COUNTY OF BOULDER, STATE OF COLORADO.




EXHIBIT B

NOTICE ADDRESSES

To Seller at:

 

To Purchaser at:

 

 

 

 

 

Circle Capital Longmont, LLC

 

Array BioPharma Inc.

 

Attn:

Terrance W. Fitzpatrick and

Attn: General Counsel

 

 

Ted Hinchman

3200 Walnut Street

 

4600 S. Ulster, Suite 590

 

Boulder, CO 80301

 

Denver, CO 80237

 

Telephone:

(303) 381-6679

Telephone:

(303)565-2736

Facsimile:

(303) 449-5376

Facsimile:

(303)565-2745

 

 

 

 

 

 

 

 

 

 

with a copy to:

 

with a copy to:

 

 

 

 

 

Lawrence J. Donovan, Jr., Esq.

 

Hogan & Hartson LLP

 

Isaacson Rosenbaum P.C.

 

Attn: Patrick K. Perrin, Esq.

 

633 17th Street, Suite 2300

 

1470 Walnut Street, #200

 

Denver, CO 80202

 

Boulder, CO 80302

 

Telephone:

(303) 292-5656

Telephone:

(720)406-5330

Facsimile:

(303) 292-3152

Facsimile:

(720)406-5301

 

 

 

 

 

 

and a copy to:

 

 

 

 

 

 

 

BioMed Realty, L.P.

 

 

 

Attn: General Counsel

 

 

 

17140 Bernardo Center Drive, Suite 222

 

 

San Diego, CA 92128

 

 

 

Telephone:

(858) 485-9840

 

 

Facsimile:

(858) 485-9843

 

 

 

 

 

 

with a copy to:

 

 

 

 

 

 

 

Latham & Watkins

 

 

 

Finance Department Notice

 

 

 

BioMed (2600-2620 Trade Centre Ave– SJL)

 

 

600 West Broadway, Suite 1800

 

 

 

San Diego, CA 92101

 

 

 

Telephone:

619-236-1234

 

 

Facsimile:

619-696-7419

 




EXHIBIT C

SPECIAL WARRANTY DEED

                                , a                                 , (“ Grantor ”), whose street address is                                 , for the consideration of TEN AND NO/100 DOLLARS ($10.00) and other good and valuable consideration, in hand paid, hereby sells and conveys to                                 , a                                  (“ Grantee ”), whose address is                                                                 , the real property located in the County of                                 , State of Colorado, that is legally described on Exhibit A attached hereto, with all its appurtenances (the “ Owned Property ”).

Grantor warrants title to the Owned Property against all persons claiming under Grantor, subject only to the matters set forth on Exhibit B attached hereto.

Signed this            day of                            , 20    .

 

GRANTOR

 

 

 

                                                               ,                             a

 

                                                              

 

 

 

By:

 

 

 

 

 

Name:

 

 

 

 

 

Title:

 

 

STATE OF COLORADO                         )

                                                                   ) ss:

COUNTY OF                                            )

The foregoing instrument was acknowledged before me this            day of                  , 20    , by            , as                      of                                      , a                           , as Grantor.

Witness my hand and official seal.

My commission expires:                                                                   
                                                                                                           

Notary Public




EXHIBIT A
TO

SPECIAL WARRANTY DEED

LEGAL DESCRIPTION

Grantor:                                                                

Grantee:                                                                




EXHIBIT B
TO

SPECIAL WARRANTY DEED

PERMITTED EXCEPTIONS




EXHIBIT D

BILL OF SALE

For valuable consideration, the receipt and sufficiency of which are hereby acknowledged,                                                                                                                                                 , a                                                                                                  (the “ Seller ”), hereby conveys to                                                 , a                                                                                                  (the “ Purchaser ”), all of Seller’s right, title and interest in and to those certain items of personal property described on Exhibit A attached hereto and made a part hereof (the “ Personal Property ”) relating to certain real property known as                                                                                                 ,                                                  ,                                                 .

Seller has not made and does not make any express or implied warranty or representation of any kind whatsoever with respect to the Personal Property, including, but not limited to: title; merchantability of the Personal Property or its fitness for any particular purpose; the design or condition of the Personal Property; the quality or capacity of the Personal Property; workmanship or compliance of the Personal Property with the requirements of any law, rule, specification or contract pertaining thereto; patent infringement or latent defects.  Purchaser accepts the Personal Property on an “AS IS, WHERE IS” basis, and “WITH ALL FAULTS.”

IN WITNESS WHEREOF, Seller has caused this instrument to be executed and delivered as of the                      day of                                ,                 .

 

,

 

 

 

 

a

 

 

 

 

 

 

 

 

 

By:

 

,

 

 

 

 

a

 

, its

 

 

 

 

 




EXHIBIT E

OWNER’S AFFIDAVIT

The undersigned, being first duly sworn on oath, hereby deposes and says that to its current actual knowledge:

1.             That affiant is the                                             of                                             (“ Owner ”), which is the owner of certain real property located in                                            , further described in Title Commitment No.                                             (the “ Property ”).

2.             That during the period of one hundred eighty (180) days immediately preceding the date of this affidavit no work has been done, and no materials have been furnished in connection with the erection, repair, or removal of any building or other structure on said premises or in connection with the improvement of said premises at Owner’s request in any manner whatsoever that have not been paid for or for which Owner shall pay following closing.

3.             During the period of Owner’s ownership of the Property, Owner’s title to the Property has never been successfully disputed, and title insurance for the Property has never been refused.

4.             Owner is validly formed and existing under the laws of the state of its organization and is in good standing in the state of its organization and the state in which the Property is located.  No proceeding is pending for Owner’s dissolution.

5.             There are no pending suits, lis pendens, judgments, bankruptcies, executions, liens for past due taxes, assessments, encumbrances, easements, deeds to secure debt, deeds of trust, mortgages, security interests, UCC financing statements, other liens securing money obligations of any kind, that are not shown by the public records and that could affect the title to the Property or constitute a lien thereon.

6.             That the premises referred to above are at present in use as                                             and that only Owner and                                            actually possesses or have the right to possess the Property.

7.             That there are no easements or claims of easements not shown by the public records and there are no encroachments, overlaps, boundary line disputes or other matters except as shown on the current survey.

8.             That there are no taxes, tax liens, assessments or utility bills which have become a lien against the premises and remain unpaid except as shown by the public records.

9.             That undersigned’s United States Taxpayer Identification Number is                                             and my United States address is                                            .




10.           That undersigned is not a “foreign person” as the term is defined in Section 1445 of the Internal Revenue Code.

DATED as of this           day of                                    , 2006.

AFFIANT:

 

By:

 

 

 

STATE OF COLORADO                      )

                                                                )  ss:

COUNTY OF                                         )

The foregoing instrument was acknowledged before me this              day of                    , 20    , by                    , as                     of                    , a                    , as Grantor.

Witness my hand and official seal.

My commission expires:                                                                             
                                                                                                                  

Notary Public



Exhibit 10.4

ASSIGNMENT OF LONGMONT PURCHASE AGREEMENT

This ASSIGNMENT AND ASSUMPTION OF PURCHASE AND SALE AGREEMENT (this “ Assignment ”) is made as of August 9, 2006 (the “ Effective Date ”), by and among Array BioPharma Inc., a Delaware corporation (“ Assignor ”), BMR-Trade Center Avenue LLC, a Delaware limited liability company (“ Assignee ”), and Circle Capital Longmont LLC, a Delaware limited liability company (“ Seller ”).

RECITALS

A.            WHEREAS, pursuant to that certain Purchase and Sale Agreement dated August 9, 2006 (as amended, the “ Purchase Agreement ”), by and between Assignor and Seller, Seller agreed to sell to Assignor, and Assignor agreed to purchase from Seller, the real property described in Exhibit “A” attached hereto (the “ Land ”) and certain improvements located on the Land; and

B.            WHEREAS, Assignor desires to assign its interest in the Purchase Agreement to Assignee.

AGREEMENT

NOW, THEREFORE, for good and valuable consideration, the receipt and adequacy of which are hereby acknowledged, the parties hereto mutually agree as follows:

1.             Defined Terms . All capitalized terms used but not otherwise defined herein shall have the meaning assigned to such terms in the Purchase Agreement.

2.             Assignment . Assignor hereby sets over, transfers and assigns unto Assignee all of Assignor’s right, title and interest in and to the Purchase Agreement.

3.             Assumption . In consideration of the foregoing assignment, Assignee hereby accepts the foregoing assignment and, from and after the execution hereof, assumes and agrees to make, observe, keep and perform all of the terms, covenants and conditions to be made, observed, kept and performed by the Assignee under the Purchase Agreement, as fully as though Assignee were originally named in the Purchase Agreement as the Purchaser.

4.             Warranty . Assignor hereby represents and warrants to Assignee that: (a) it has not assigned the Purchase Agreement to any other person or entity, and (b) it is not in breach or default of any of its obligations under the Purchase Agreement.

5.             Indemnification . Assignor shall defend, indemnify and hold harmless Assignee from and against any liability, damages, causes of action, expenses, and attorneys’ fees incurred by Assignee by reason of the failure of Assignor to fulfill, perform, discharge, and observe its obligations with respect to the Purchase Agreement arising before the Effective Date. Assignee shall defend, indemnify and hold harmless Assignor from and against any liability, damages, causes of action, expenses, and attorneys’ fees incurred by Assignor by reason of the failure of Assignor to fulfill, perform, discharge, and observe its obligations with respect to the Purchase Agreement arising on or after the Effective Date.

6.             Governing Law . This Assignment shall be governed by the law of the State of Colorado.

7.             Counterparts . This Assignment may be executed in one or more counterparts, each of which shall be deemed an original, but all of which together will constitute one and the same instrument executed on the date first set forth.




IN WITNESS WHEREOF, the parties hereto have executed this Assignment as of the date first above written.

 

ASSIGNOR:

 

 

 

 

 

ARRAY BIOPHARMA INC.,

 

 

a Delaware corporation

 

 

 

 

 

By:

 

 

 

 

Name: Mike Carruthers

 

 

 

Title: CFO

 

 

 

 

ASSIGNEE:

 

 

 

 

 

BMR-TRADE CENTRE AVENUE LLC,

 

 

a Delaware limited liability company

 

 

 

 

 

By:

BIOMED REALTY, L.P.,

 

 

 

a Maryland limited partnership

 

 

 

its sole member

 

 

 

 

 

 

 

 

By:

 

 

 

 

 

Name:

 

 

 

Title:

 

 

ACKNOWLEDGED AND AGREED:

 

 




 

CIRCLE CAPITAL LONGMONT, LLC,

a Delaware limited liability company

 

By:

Longmont Senior Mezzanine Owner LLC,

 

a Delaware limited liability company,

 

its Sole Member and Manager

 

 

 

By:

Longmont Junior Mezzanine Owner LLC,

 

 

a Delaware limited liability company,

 

 

its Sole Member and Manager

 

 

 

 

 

By:

Circle Longmont Limited Partnership,

 

 

 

a Delaware limited partnership,

 

 

 

its Sole Member and Manager

 

 

 

 

 

 

 

By:

Circle Capital Longmont GP LLC,

 

 

 

 

a Colorado limited liability company,

 

 

 

 

its General Partner

 

 

 

 

 

 

 

 

By:

 

 

 

 

 

 

Name: Terrence W. Fitzpatrick

 

 

 

 

Title: Manager

 




EXHIBIT A

LAND

Lots 1 and 2, St. Vrain Centre Parcel F-Minor Subdivision “C”, the Plat of which was recorded August 21, 1997 Reception No. 1724602 in Plan File P-40, F-3, No. 49, County of Boulder, State of Colorado.



Exhibit 10.5

SECOND AMENDMENT
TO LOAN AND SECURITY AGREEMENT, CONSENT AND WAIVER

This Second Amendment to Loan and Security Agreement, Consent and Waiver (this “Amendment”) is entered into as of July 7, 2006, by and between COMERICA BANK (“Bank”) and ARRAY BIOPHARMA, INC. (“Borrower”).

RECITALS

A.            Borrower and Bank are parties to that certain Loan and Security Agreement dated as of June 28, 2005, as amended from time to time, including by that certain First Amendment to Loan and Security Agreement dated as of December 19, 2005 (the “Agreement”).

B.            Borrower has informed Bank that it intends to transfer certain options to purchase (the “Purchase Options”) properties located in Boulder, Colorado and Longmont, Colorado (collectively, the “Properties” and each individually, a “Property”) to BioMed Realty Trust (“BioMed”).  In connection with the transfer of the Purchase Options, Borrower will enter into agreements with BioMed to assign the Purchase Options to and lease such Properties from BioMed (“Assignment/Leaseback Transactions”).

C.            Pursuant to Sections 7.1 and 7.7 of the Agreement, Borrower is prohibited from selling, transferring or disposing of Collateral and making Investments.  Borrower has requested that Bank consent to the Assignment/Leaseback Transactions and waive the provisions of Sections 7.1 and 7.7 of the Agreement to the extent needed to permit the Assignment/Leaseback Transactions to be consummated.  Subject to and on the terms set forth herein, Bank has agreed to provide such waiver and consent.

D.            The parties also desire to amend the Agreement in accordance with the terms of this Amendment.

NOW, THEREFORE, the parties agree as follows:

1.             Subject to the terms hereof, Bank hereby consents, for the purposes of Sections 7.1 and 7.7 of the Agreement, to the Assignment/Leaseback Transactions and waives Borrower’s compliance with Sections 7.1 and 7.7 only for the purpose of consummating the Assignment/Leaseback Transactions.  However, the effectiveness of Bank’s consent and waiver is contingent upon Borrower’s delivery to Bank of executed landlord waivers, substantially in the form of the Lessor’s Acknowledgment and Subordination attached hereto as Annex I, that are effective as of the date of each applicable Assignment/Leaseback Transaction, from BioMed covering each Property.  Bank’s consent to the Assignment/Leaseback Transactions and related waiver: (a) shall in no way be deemed an agreement by Bank to waive any other covenant, liability or obligation of Borrower or any third party or to waive any right, power or remedy of Bank; (b) shall not limit or impair Bank’s right to demand strict performance of Borrower’s liabilities and obligations to Bank and the Obligations under the Agreement at all times following the consummation of the Assignment/Leaseback Transactions, including Sections 7.1 and 7.7; and (c) shall in no way obligate Bank to make any future waivers, consents or modifications to the Agreement.  Borrower acknowledges that Bank is relying upon Borrower’s representations, warranties and agreements as set forth herein and in the Loan Documents in consenting to the Assignment/Leaseback Transactions.

2.             Section 1.1 of the Agreement is hereby amended by adding or amending and restating the following terms:

“‘Cash at Bank’ means Cash at Bank and Cash at Comerica Securities, Inc. covered by an Account Control Agreement.”

“‘Cash at Lehman’ means Cash held at Lehman Brothers covered by an Account Control Agreement.”

1




“‘Letter of Credit Sublimit’ means a sublimit for Letters of Credit under the Revolving Line not to exceed $6,750,000.”

“‘Revolving Line’ means a Credit Extension of up to $6,750,000.”

3.             Section 6.6 of the Agreement is hereby amended and restated to read in its entirety as follows:

“6.6         Minimum Cash at Bank .  Borrower shall at all times, measured on a daily basis, maintain a balance of Cash at Bank of not less than: (i) Zero Dollars ($0) if Borrower’s total Cash at Bank plus Cash at Lehman is not less than Forty Million Dollars ($40,000,000), (ii) Two Million Dollars ($2,000,000) if Borrower’s total Cash at Bank plus Cash at Lehman is at least Thirty Million Dollars ($30,000,000) but less than Forty Million Dollars, (iii) Thirteen Million Dollars ($13,000,000) if Borrower’s total Cash at Bank plus Cash at Lehman is at least Twenty Seven Million Five Hundred Thousand Dollars ($27,500,000) but less than Thirty Million ($30,000,000) and (iv) Twenty Four Million Dollars ($24,000,000) if Borrower’s total Cash at Bank plus Cash at Lehman is less than Twenty Seven Million Five Hundred Thousand Dollars ($27,500,000).  Notwithstanding the foregoing, if Borrower fails to comply with any of the provisions of this Section 6.6 at any time, Borrower shall have two (2) Business Days from the date of such failure to deposit additional funds in accounts at Bank, Comerica Securities Inc., Lehman Brothers or other accounts covered by Account Control Agreements so that Borrower is in compliance with this Section 6.6.”

4.             Exhibit C to the Agreement is hereby replaced with Exhibit C attached hereto.

5.             Sections 11 and 12 of the Agreement are hereby amended and restated in their entirety to read as follows:

“11.         CHOICE OF LAW AND VENUE; JURY TRIAL WAIVER .

This Agreement shall be governed by, and construed in accordance with, the internal laws of the State of California, without regard to principles of conflicts of law.  Borrower and Bank hereby submit to the exclusive jurisdiction of the state and Federal courts located in the County of Santa Clara, State of California.  THE UNDERSIGNED ACKNOWLEDGE THAT THE RIGHT TO TRIAL BY JURY IS A CONSTITUTIONAL ONE, BUT THAT IT MAY BE WAIVED UNDER CERTAIN CIRCUMSTANCES.  TO THE EXTENT PERMITTED BY LAW, EACH PARTY, AFTER CONSULTING (OR HAVING HAD THE OPPORTUNITY TO CONSULT) WITH COUNSEL OF ITS CHOICE, KNOWINGLY AND VOLUNTARILY, AND FOR THE MUTUAL BENEFIT OF ALL PARTIES, WAIVES ANY RIGHT TO TRIAL BY JURY IN THE EVENT OF LITIGATION ARISING OUT OF OR RELATED TO THIS AGREEMENT OR ANY OTHER DOCUMENT, INSTRUMENT OR AGREEMENT BETWEEN THE UNDERSIGNED PARTIES.

12.        JUDICIAL REFERENCE PROVISION .

(a)           In the event the Jury Trial Waiver set forth above is not enforceable, the parties elect to proceed under this Judicial Reference Provision.

(b)           With the exception of the items specified in clause (c), below, any controversy, dispute or claim (each, a “Claim”) between the parties arising out of or relating to this Agreement or any other document, instrument or agreement between the undersigned parties (collectively in this Section, the “Comerica Documents”), will be resolved by a reference proceeding in California in accordance with the provisions of Sections 638 et seq. of the California Code of Civil Procedure (“CCP”), or their successor sections, which shall constitute the exclusive remedy for the resolution of any Claim, including whether the Claim is subject to the reference proceeding. Except as otherwise provided in the Comerica Documents, venue for the reference proceeding will be in the state or federal court in the county or district where the real property involved in the action, if any, is located or in the state or federal court in the county or district where venue is otherwise appropriate under applicable law (the “Court”).

2




(c)           The matters that shall not be subject to a reference are the following: (i) nonjudicial foreclosure of any security interests in real or personal property, (ii) exercise of self-help remedies (including, without limitation, set-off), (iii) appointment of a receiver and (iv) temporary, provisional or ancillary remedies (including, without limitation, writs of attachment, writs of possession, temporary restraining orders or preliminary injunctions). This reference provision does not limit the right of any party to exercise or oppose any of the rights and remedies described in clauses (i) and (ii) or to seek or oppose from a court of competent jurisdiction any of the items described in clauses (iii) and (iv). The exercise of, or opposition to, any of those items does not waive the right of any party to a reference pursuant to this reference provision as provided herein.

(d)           The referee shall be a retired judge or justice selected by mutual written agreement of the parties. If the parties do not agree within ten (10) days of a written request to do so by any party, then, upon request of any party, the referee shall be selected by the Presiding Judge of the Court (or his or her representative). A request for appointment of a referee may be heard on an ex parte or expedited basis, and the parties agree that irreparable harm would result if ex parte relief is not granted.  Pursuant to CCP § 170.6, each party shall have one peremptory challenge to the referee selected by the Presiding Judge of the Court (or his or her representative).

(e)           The parties agree that time is of the essence in conducting the reference proceedings. Accordingly, the referee shall be requested, subject to change in the time periods specified herein for good cause shown, to (i) set the matter for a status and trial-setting conference within fifteen (15) days after the date of selection of the referee, (ii) if practicable, try all issues of law or fact within one hundred twenty (120) days after the date of the conference and (iii) report a statement of decision within twenty (20) days after the matter has been submitted for decision.

(f)            The referee will have power to expand or limit the amount and duration of discovery.  The referee may set or extend discovery deadlines or cutoffs for good cause, including a party’s failure to provide requested discovery for any reason whatsoever. Unless otherwise ordered based upon good cause shown, no party shall be entitled to “priority” in conducting discovery, depositions may be taken by either party upon seven (7) days written notice, and all other discovery shall be responded to within fifteen (15) days after service. All disputes relating to discovery which cannot be resolved by the parties shall be submitted to the referee whose decision shall be final and binding.

(g)           Except as expressly set forth herein, the referee shall determine the manner in which the reference proceeding is conducted including the time and place of hearings, the order of presentation of evidence, and all other questions that arise with respect to the course of the reference proceeding.  All proceedings and hearings conducted before the referee, except for trial, shall be conducted without a court reporter, except that when any party so requests, a court reporter will be used at any hearing conducted before the referee, and the referee will be provided a courtesy copy of the transcript. The party making such a request shall have the obligation to arrange for and pay the court reporter. Subject to the referee’s power to award costs to the prevailing party, the parties will equally share the cost of the referee and the court reporter at trial.

(h)           The referee shall be required to determine all issues in accordance with existing case law and the statutory laws of the State of California. The rules of evidence applicable to proceedings at law in the State of California will be applicable to the reference proceeding. The referee shall be empowered to enter equitable as well as legal relief, enter equitable orders that will be binding on the parties and rule on any motion which would be authorized in a court proceeding, including without limitation motions for summary judgment or summary adjudication. The referee shall issue a decision at the close of the reference proceeding which disposes of all claims of the parties that are the subject of the reference.  Pursuant to CCP § 644, such decision shall be entered by the Court as a judgment or an order in the same manner as if the action had been tried by the Court and any such decision will be final, binding and conclusive.  The parties reserve the right to appeal from the final judgment or order or from any appealable decision or order entered by the referee.  The parties reserve the right to findings of fact, conclusions of laws, a written statement of decision, and the right to move for a new trial or a different judgment, which new trial, if granted, is also to be a reference proceeding under this provision.

3




(i)            If the enabling legislation which provides for appointment of a referee is repealed (and no successor statute is enacted), any dispute between the parties that would otherwise be determined by reference procedure will be resolved and determined by arbitration.  The arbitration will be conducted by a retired judge or justice, in accordance with the California Arbitration Act §1280 through §1294.2 of the CCP as amended from time to time. The limitations with respect to discovery set forth above shall apply to any such arbitration proceeding.

(j)            THE PARTIES RECOGNIZE AND AGREE THAT ALL CONTROVERSIES, DISPUTES AND CLAIMS RESOLVED UNDER THIS REFERENCE PROVISION WILL BE DECIDED BY A REFEREE AND NOT BY A JURY. AFTER CONSULTING (OR HAVING HAD THE OPPORTUNITY TO CONSULT) WITH COUNSEL OF ITS  OWN CHOICE, EACH PARTY KNOWINGLY AND VOLUNTARILY, AND FOR THE MUTUAL BENEFIT OF ALL PARTIES, AGREES THAT THIS REFERENCE PROVISION WILL APPLY TO ANY CONTROVERSY, DISPUTE OR CLAIM BETWEEN OR AMONG THEM ARISING OUT OF OR IN ANY WAY RELATED TO, THIS AGREEMENT OR THE OTHER COMERICA DOCUMENTS.”

6.             No course of dealing on the part of Bank or its officers, nor any failure or delay in the exercise of any right by Bank, shall operate as a waiver thereof, and any single or partial exercise of any such right shall not preclude any later exercise of any such right.  Bank’s failure at any time to require strict performance by Borrower of any provision shall not affect any right of Bank thereafter to demand strict compliance and performance.  Any suspension or waiver of a right must be in writing signed by an officer of Bank.

7.             Unless otherwise defined, all initially capitalized terms in this Amendment shall be as defined in the Agreement.  The Agreement, as amended hereby, shall be and remain in full force and effect in accordance with its respective terms and hereby is ratified and confirmed in all respects.  Except as expressly set forth herein, the execution, delivery, and performance of this Amendment shall not operate as a waiver of, or as an amendment of, any right, power, or remedy of Bank under the Agreement, as in effect prior to the date hereof.

8.             Borrower represents and warrants that the Representations and Warranties contained in the Agreement are true and correct as of the date of this Amendment, and that no Event of Default has occurred and is continuing.

9.             Except as otherwise provided herein, as a condition to the effectiveness of this Amendment, Bank shall have received, in form and substance satisfactory to Bank, the following:

(a)           this Amendment, duly executed by Borrower;

(b)           a Certificate of the Secretary of Borrower with respect to incumbency and resolutions authorizing the execution and delivery of this Amendment;

(c)           all reasonable Bank Expenses incurred through the date of this Amendment, which may be debited from any of Borrower’s accounts;

(d)           an Amendment to Pledged Collateral Account Agreement (re Lehman account);

(e)           a Securities Account Control Agreement (re Comerica Securities account);

(f)            an Agreement to Provide Insurance in the form attached hereto;

(g)           an Itemization of Amount Financed Disbursement Instruction in the form attached hereto; and

(h)           such other documents, and completion of such other matters, as Bank may reasonably deem necessary or appropriate.

4




10.           This Amendment may be executed in two or more counterparts, each of which shall be deemed an original, but all of which together shall constitute one instrument.

IN WITNESS WHEREOF, the undersigned have executed this Amendment as of the first date above written.

ARRAY BIOPHARMA, INC.

 

 

 

 

 

By:

 

 

 

 

Title:

 

 

 

 

 

 

COMERICA BANK

 

 

 

 

 

By:

 

 

 

 

Title:

 

 

5




EXHIBIT C

COMPLIANCE CERTIFICATE

TO:

COMERICA BANK

FROM:

ARRAY BIOPHARMA, INC.

 

The undersigned authorized officer of ARRAY BIOPHARMA, INC. hereby certifies that in accordance with the terms and conditions of the Loan and Security Agreement between Borrower and Bank (as amended from time to time, the “Agreement”), (i) Borrower is in complete compliance for the period ending                                with all required covenants except as noted below and (ii) all representations and warranties of Borrower stated in the Agreement are true and correct as of the date hereof.  Attached herewith are the required documents supporting the above certification.  The Officer further certifies that these are prepared in accordance with Generally Accepted Accounting Principles (GAAP) and are consistently applied from one period to the next except as explained in an accompanying letter or footnotes.

Please indicate compliance status by circling Yes/No under “Complies” column.

Reporting Covenant

 

Required

 

Complies

 

 

 

 

 

 

 

Monthly financial statements

 

Monthly within 20 days

 

Yes

 

No

Annual (CPA Audited)

 

Within 5 days of SEC 10-K filing requirements

 

Yes

 

No

10K and 10Q

 

Within 5 days of filing

 

Yes

 

No

Cash Balance Certificate

 

Monthly within 5 days plus daily real time monitoring

 

Yes

 

No

Compliance Cert.

 

Monthly within 20 days AND w/in 5 days of SEC 10-Q filing requirements

 

Yes

 

No

A/R Audit

 

Initial and Semi-Annual

 

Yes

 

No

 

Financial Covenant

 

Required

 

Actual

 

Complies

 

 

 

 

 

 

 

 

 

 

 

Measured on a Daily Basis:

 

 

 

 

 

 

 

 

 

Minimum Cash at Bank:

 

 

 

 

 

 

 

 

 

If total Cash at Bank and Cash at Lehman is at least $30,000,000 but less than $40,000,000

 

$

2,000,000

 

$

              

 

Yes

 

No

 

If total at Bank and Cash at Lehman is less than $30,000,000 but greater than $27,500,000

 

$

13,000,000

 

$

              

 

Yes

 

No

 

If total Cash at Bank and Cash at Lehman is less than $27,500,000

 

$

24,000,000

 

$

              

 

Yes

 

No

 

 

Comments Regarding Exceptions: See Attached

BANK USE ONLY

 

 

Sincerely,

Received by:

 

 

 

AUTHORIZED SIGNER

 

 

 

Date:

 

 

SIGNATURE

 

 

Verified:

 

 

 

 

 

AUTHORIZED SIGNER

 

TITLE

Date:

 

 

 

 

 

 

Compliance Status

Yes

No

 

DATE

 

 

1




Corporation Resolutions and Incumbency Certification
Authority to Procure Loans

I certify that I am the duly elected and qualified Secretary of  ARRAY BIOPHARMA, INC.; that the following is a true and correct copy of resolutions duly adopted by the Board of Directors of the Corporation in accordance with its bylaws and applicable statutes.

Copy of Resolutions:

Be it Resolved, That:

1.                                        Any one (1) of the following                                                      (insert titles only) of the Corporation are/is authorized, for, on behalf of, and in the name of the Corporation to:

(a)                                   Negotiate and procure loans, letters of credit and other credit or financial accommodations from Comerica Bank (“Bank”), a Michigan banking corporation, including, without limitation, that certain Loan and Security Agreement dated as of June 28, 2005, as amended from time to time, including but not limited to that certain First Amendment to Loan and Security Agreement dated as of December 19, 2005 and that certain Second Amendment to Loan and Security Agreement, Consent and Waiver dated as of July 7, 2006 (collectively, the “Agreement”).

(b)                                  Discount with the Bank, commercial or other business paper belonging to the Corporation made or drawn by or upon third parties, without limit as to amount;

(c)                                   Purchase, sell, exchange, assign, endorse for transfer and/or deliver certificates and/or instruments representing stocks, bonds, evidences of Indebtedness or other securities owned by the Corporation, whether or not registered in the name of the Corporation;

(d)                                  Give security for any liabilities of the Corporation to the Bank by grant, security interest, assignment, lien, deed of trust or mortgage upon any real or personal property, tangible or intangible of the Corporation;

(e)                                   Issue a warrant or warrants to purchase the Corporation’s capital stock; and

(f)                                     Execute and deliver in form and content as may be required by the Bank any and all notes, evidences of Indebtedness, applications for letters of credit, guaranties, subordination agreements, loan and security agreements, financing statements, assignments, liens, deeds of trust, mortgages, trust receipts and other agreements, instruments or documents to carry out the purposes of these Resolutions, any or all of which may relate to all or to substantially all of the Corporation’s property and assets.

2.                                        Said Bank be and it is authorized and directed to pay the proceeds of any such loans or discounts as directed by the persons so authorized to sign, in accordance with the Agreement.

3.                                        Any and all agreements, instruments and documents previously executed and acts and things previously done to carry out the purposes of these Resolutions are ratified, confirmed and approved as the act or acts of the Corporation.

4.                                        These Resolutions shall continue in force, and the Bank may consider the holders of said offices and their signatures to be and continue to be as set forth in a certified copy of these Resolutions delivered to the Bank, until notice to the contrary in writing is duly served on the Bank (such notice to have no effect on any action previously taken by the Bank in reliance on these Resolutions).

1




5.                                        Any person, corporation or other legal entity dealing with the Bank may rely upon a certificate signed by an officer of the Bank to the effect that these Resolutions and any agreement, instrument or document executed pursuant to them are still in full force and effect and binding upon the Corporation.

6.                                        The Bank may consider the holders of the offices of the Corporation and their signatures, respectively, to be and continue to be as set forth in the Certificate of the Secretary of the Corporation until notice to the contrary in writing is duly served on the Bank.

I further certify that the above Resolutions are in full force and effect as of the date of this Certificate; that these Resolutions and any borrowings or financial accommodations under these Resolutions have been properly noted in the corporate books and records, and have not been rescinded, annulled, revoked or modified; that neither the foregoing Resolutions nor any actions to be taken pursuant to them are or will be in contravention of any provision of the articles of incorporation or bylaws of the Corporation or of any agreement, indenture or other instrument to which the Corporation is a party or by which it is bound; and that neither the articles of incorporation nor bylaws of the Corporation nor any agreement, indenture or other instrument to which the Corporation is a party or by which it is bound require the vote or consent of shareholders of the Corporation to authorize any act, matter or thing described in the foregoing Resolutions.

I further certify that the following named persons have been duly elected to the offices set opposite their respective names, that they continue to hold these offices at the present time, and that the signatures which appear below are the genuine, original signatures of each respectively:

(PLEASE SUPPLY GENUINE SIGNATURES OF AUTHORIZED SIGNERS BELOW)

NAME (Type or Print)

 

TITLE

 

SIGNATURE

        

 

 

 

 

        

 

 

 

 

 

In Witness Whereof, I have affixed my name as Secretary and have caused the corporate seal (where available) of said Corporation to be affixed on July 7, 2006.

 

 

 

Secretary, ARRAY BIOPHARMA, INC.

 

 

The Above Statements are Correct.

 

 

SIGNATURE OF OFFICER OR DIRECTOR OR, IF NONE. A
SHAREHOLDER OTHER THAN SECRETARY WHEN SECRETARY IS
AUTHORIZED TO SIGN ALONE.

 

Failure to complete the above when the Secretary is authorized to sign alone shall constitute a certification by the Secretary that the Secretary is the sole Shareholder, Director and Officer of the Corporation.

2




COMERICA BANK
Member FDIC

ITEMIZATION OF AMOUNT FINANCED
DISBURSEMENT INSTRUCTIONS
(Revolver)

Name:  ARRAY BIOPHARMA, INC.

Date:  July 7, 2006

 

$6,750,000 credited to deposit account No.                        when Advances are requested or disbursed to Borrower by cashiers check or wire transfer

Amounts paid to others on your behalf:

 

$

                      

 

to Comerica Bank for Loan Fee

 

 

 

 

 

$

                      

 

to Comerica Bank for Document Fee

 

 

 

 

 

$

                      

 

to Comerica Bank for accounts receivable audit (estimate)

 

 

 

 

 

$

                      

 

to Bank counsel fees and expenses

 

 

 

 

 

$

                      

 

to                      

 

 

 

 

 

$

                      

 

to                      

 

 

 

 

 

$

                      

 

TOTAL (AMOUNT FINANCED)

 

 

Upon consummation of this transaction, this document will also serve as the authorization for Comerica Bank to disburse the loan proceeds as stated above.

 

 

 

Signature

 

Signature

 

1




AGREEMENT TO PROVIDE INSURANCE

TO:

COMERICA BANK

Date: July 7, 2006

 

attn: Deni M. Snider, MC 4770

 

 

75 E. Trimble Road

 

 

San Jose, CA 95131

 

 

Borrower:  ARRAY BIOPHARMA, INC.

In consideration of a loan in the amount of $21,750,000, secured by all tangible personal property including inventory and equipment.

I/We agree to obtain adequate insurance coverage to remain in force during the term of the loan.

I/We also agree to advise the below named agent to add Comerica Bank as lender’s loss payable on the new or existing insurance policy, and to furnish Bank at above address with a copy of said policy/endorsements and any subsequent renewal policies.

I/We understand that the policy must contain:

1.             Fire and extended coverage in an amount sufficient to cover:

The amount of the loan, OR

All existing encumbrances, whichever is greater,

But not in excess of the replacement value of the improvements on the real property.

2.             Lender’s “Loss Payable” Endorsement Form 438 BFU in favor of Comerica Bank, or any other form acceptable to Bank.

INSURANCE INFORMATION

Insurance Co./Agent

Telephone No.:

 

 

Agent’s Address:

 

 

 

Signature of Obligor:

 

 

 

 

 

 

 

Signature of Obligor:

 

 

 

FOR BANK USE ONLY

 

INSURANCE VERIFICATION: Date:

 

 

 

Person Spoken to:

 

 

 

Policy Number:

 

 

 

Effective From:

 

To:

 

 

 

Verified by:

 

 

 




ANNEX I

 

Lessor’s Acknowledgment and Subordination
(For Use Without Assignment of Lease)

As of                       , 2006, the undersigned,                                                  (“Lessor”), under the terms of a lease, a copy of which is attached hereto (the “Lease”), acknowledges that, Array Biopharma, Inc. (“Lessee”), has or will receive from Comerica Bank (“Bank”) certain credit accommodations.

Notice    Lessor agrees to notify Bank in writing (at the address specified below or at any other address given by Bank in writing to Lessor) not less than thirty (30) days before commencing any proceedings or otherwise taking any action to terminate the Lease or to enforce its remedies thereunder.

Subordination    Lessor agrees that all of Lessee’s machinery, equipment, inventory, fixtures or other property (“Lessee’s Property”) which may be located on the leased premises shall remain the personal property of the Lessee and shall not become a fixture or part of the realty notwithstanding anything that may be implied by law from the mode of attachment, installation or otherwise.  Lessor further agrees that any lien or security interest Lessor may claim against any of Lessee’s Property is subordinated to any lien or security interest now or subsequently held by Bank in any of such property.

Limited Right of Entry    Lessor acknowledges that, notwithstanding any noncompliance with or default by Lessee under the Lease, the Bank shall have the limited right to enter into and remain in possession of the leased premises for a reasonable period not to exceed ninety (90) consecutive days for the purpose of enforcing its liens and security interests in Lessee’s Property, including the sale and/or detachment and/or removal from the leased premises of such property.  Bank shall pay to Lessor, on a monthly basis in advance (pro rata, depending on the number of days Bank is in possession), the amount equal to the current monthly rent accruing under the Lease during the period while Bank is in possession of the leased premises; provided however , that Bank shall not assume or be deemed to have assumed any obligations of Lessee under such Lease and shall not incur any liabilities or obligations whatsoever with respect to the Lease other than the payments described in this paragraph.  Furthermore, Bank shall have no responsibility whatsoever for any back rent or other obligations which have accrued under the Lease prior to Bank’s entry into possession under this paragraph.

No Assumption    Lessor further agrees that Bank’s rights have been given for security purposes only, and that unless and until Bank agrees expressly and in writing to do so, Bank shall have no obligations whatsoever under the Lease.

ADDRESS OF LEASED PREMISES:

LESSOR:

 

 

 

 

 

By:

 

 

 

 

Name:

 

 

 

 

Title:

 

 

 

 

 

 

 

ADDRESS OF COMERICA BANK:

BANK: Comerica Bank

 

 

 

Comerica Bank

 

By:

 

75 E. Trimble Road

 

Name:

 

San Jose, CA 95131

 

Title:

 

 

 

 

 

 

 

ACKNOWLEDGEMENT OF LESSEE:

LESSEE: Array Biopharma, Inc.

 

 

 

 

 

By:

 

 

 

Name:

 

 

 

Title:

 

 



Exhibit 10.6

 

 


August 31, 2006

VIA FAX AND FEDERAL EXPRESS

David L. Snitman, Ph.D.

Chief Operating Officer

Array BioPharma, Inc.

3200 Walnut Street Boulder, CO 80301

RE:

 

Drug Discovery Collaboration Agreement dated September 13, 2002 — Exercise of Option to Extend Funding of Research FTEs

 

Dear Dr. Snitman:

As you know, InterMune, Inc. (“ InterMune ”) and Array BioPharma Inc. (“ Array ”) are parties to that certain Drug Discovery Collaboration Agreement dated September 13, 2002, as amended by Amendment No.1 dated May 8, 2003, Amendment No.2 dated January 7, 2004, Amendment No.3 dated September 10, 2004, Amendment No.4 dated December 7, 2004, Amendment No.5 dated June 30, 2005, Amendment No.6 dated February 3, 2006 and effective January 1, 2006, and Amendment No. 7 dated June 28, 2006 (collectively, the “ Agreement ”). Any capitalized term contained herein and not otherwise defined herein shall have the meaning ascribed to such term in the Agreement.

Section 5.1.1 of the Agreement provides that the Research FTEs will be funded by InterMune through August 31, 2006 but that InterMune has an option to extend such funding for an additional six (6) month period.  InterMune is hereby notifying Array that it is exercising its option such that the funding of the Research FTEs will now be funded through February 28, 2007.  In addition, the Parties hereby acknowledge and agree that Array shall make available and InterMune shall fund a total of three (3) Research FTEs (as opposed to the two (2) Research FTEs currently provided for in Section 5.1.1 of the Agreement) from September 31, 2006 through February 28, 2007 (“Research FTE Extension Term”).  During the Research FTE Extension Term, the three (3) Research FTEs will perform the tasks outlined in that certain document entitled “Process Research Activities for the InterMune-Array Collaboration” that is currently in the process of being approved as part of the Research Plan and will be implemented by the Joint Research Committee.

Please acknowledge your agreement to the foregoing by having an authorized Array representative countersign both enclosed copies of this letter where indicated below, and returning one original to the attention of Lucinda Y. Quan, Director, Legal Affairs at InterMune. We would be happy to proceed based on receipt of a facsimile copy while awaiting the original.




 

If you have any questions on the foregoing, please do not hesitate to contact me.

Sincerely,

 

Robin Steele

Senior Vice President, General Counsel

cc:

General Counsel, Array

 

Mr. Larry Kahn, InterMune

 

Lawrence Blatt, PhD, InterMune

Acknowledged and Agreed:

ARRAY BIOPHARMA INC.

 

By:

 

 

 

 

 

Name:

 

 

 

 

 

Title:

 

 

 



Exhibit 31.1

CERTIFICATION UNDER SECTION 302 OF THE SARBANES-OXLEY ACT OF 2002

I, Robert E. Conway, certify that:

1. I have reviewed this quarterly report on Form 10-Q of Array BioPharma Inc.;

2. Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this report;

3. Based on my knowledge, the financial statements, and other financial information included in this report, fairly present in all material respects the financial condition, results of operations and cash flows of the registrant as of, and for, the periods presented in this report;

4. The registrant’s other certifying officer and I are responsible for establishing and maintaining disclosure controls and procedures (as defined in Exchange Act Rules 13a-15(e) and 15d-15(e)) and internal control over financial reporting (as defined in Exchange Act Rules 13a-15(f) and 15d-15(f)) for the registrant and have:

a) Designed such disclosure controls and procedures, or caused such disclosure controls and procedures to be designed under our supervision, to ensure that material information relating to the registrant is made known to us by others within this entity, particularly during the period in which this report is being prepared;

b) Designed such internal control over financial reporting, or caused such internal control over financial reporting to be designed under our supervision, to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external purposes in accordance with generally accepted accounting principles;

c) Evaluated the effectiveness of the registrant’s disclosure controls and procedures and presented in this report our conclusions about the effectiveness of the disclosure controls and procedures, as of the end of the period covered by this report based on such evaluation; and

d) Disclosed in this report any change in the registrant’s internal control over financial reporting that occurred during the registrant’s most recent fiscal quarter (the registrant’s fourth fiscal quarter in the case of an annual report) that has materially affected, or is reasonably likely to materially affect, the registrant’s internal control over financial reporting; and

5. The registrant’s other certifying officer and I have disclosed, based on our most recent evaluation of internal control over financial reporting, to the registrant’s auditors and the audit committee of the registrant’s board of directors (or persons performing the equivalent functions):

a) All significant deficiencies and material weaknesses in the design or operation of internal control over financial reporting which are reasonably likely to adversely affect the registrant’s ability to record, process, summarize and report financial information; and

b) Any fraud, whether or not material, that involves management or other employees who have a significant role in the registrant’s internal control over financial reporting.

Date: November 6, 2006

/s/ Robert E. Conway

 

 

 

 

Robert E. Conway

 

Chief Executive Officer

 

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Exhibit 31.2

CERTIFICATION UNDER SECTION 302 OF THE SARBANES-OXLEY ACT OF 2002

I, R. Michael Carruthers, certify that:

1. I have reviewed this quarterly report on Form 10-Q of Array BioPharma Inc.;

2. Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this report;

3. Based on my knowledge, the financial statements, and other financial information included in this report, fairly present in all material respects the financial condition, results of operations and cash flows of the registrant as of, and for, the periods presented in this report;

4. The registrant’s other certifying officer and I are responsible for establishing and maintaining disclosure controls and procedures (as defined in Exchange Act Rules 13a-15(e) and 15d-15(e)) and internal control over financial reporting (as defined in Exchange Act Rules 13a-15(f) and 15d-15(f)) for the registrant and have:

a) Designed such disclosure controls and procedures, or caused such disclosure controls and procedures to be designed under our supervision, to ensure that material information relating to the registrant is made known to us by others within this entity, particularly during the period in which this report is being prepared;

b) Designed such internal control over financial reporting, or caused such internal control over financial reporting to be designed under our supervision, to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external purposes in accordance with generally accepted accounting principles;

c) Evaluated the effectiveness of the registrant’s disclosure controls and procedures and presented in this report our conclusions about the effectiveness of the disclosure controls and procedures, as of the end of the period covered by this report based on such evaluation; and

d) Disclosed in this report any change in the registrant’s internal control over financial reporting that occurred during the registrant’s most recent fiscal quarter (the registrant’s fourth fiscal quarter in the case of an annual report) that has materially affected, or is reasonably likely to materially affect, the registrant’s internal control over financial reporting; and

5. The registrant’s other certifying officer and I have disclosed, based on our most recent evaluation of internal control over financial reporting, to the registrant’s auditors and the audit committee of the registrant’s board of directors (or persons performing the equivalent functions):

a) All significant deficiencies and material weaknesses in the design or operation of internal control over financial reporting which are reasonably likely to adversely affect the registrant’s ability to record, process, summarize and report financial information; and

b) Any fraud, whether or not material, that involves management or other employees who have a significant role in the registrant’s internal control over financial reporting.

Date: November 6, 2006

/s/ R. Michael Carruthers

 

 

 

 

R. Michael Carruthers

 

Chief Financial Officer

 

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Exhibit 32.0

CERTIFICATES PURSUANT TO 18 U.S.C. SECTION 1350,

AS ADOPTED PURSUANT TO

SECTION 906 OF THE SARBANES-OXLEY ACT OF 2002

The undersigned, Robert E. Conway, Chief Executive Officer of Array BioPharma Inc. (the “Company”) and R. Michael Carruthers, Chief Financial Officer of the Company, do each hereby certify that, to the best of his knowledge and except as corrected or supplemented in a subsequent periodic report filed pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934, as amended (the “Exchange Act”), as of the date hereof:

(a) the Quarterly Report on Form 10-Q of the Company for the three-month period ended September 30, 2006, filed on the date hereof with the Securities and Exchange Commission (the “Report”) fully complies with the requirements of Section 13(a) or 15(d) of the Exchange Act; and

(b) the information contained in the Report fairly presents, in all material respects, the financial condition and results of operations of the Company.

A signed original of this written statement required by Section 906 has been provided to the Company and will be retained by the Company and furnished to the Securities and Exchange Commission or its staff upon request.

The undersigned have executed this Certificate as of the 6th day of November 2006.

 

/s/ Robert E. Conway

 

 

 

 

Robert E. Conway

 

Chief Executive Officer

 

 

 

 

 

/s/ R. Michael Carruthers

 

 

R. Michael Carruthers

 

Chief Financial Officer

 

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