UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, DC 20549

FORM 10-Q

(Mark One)

 

þ

Quarterly report pursuant to section 13 or 15(d) of the Securities Exchange Act of 1934

For the quarterly period ended:  September 30, 2016

o

Transition report pursuant to section 13 or 15(d) of the Securities Exchange Act of 1934

For the transition period from: _______ to _____________

001-14494
Commission File Number

PERNIX THERAPEUTICS HOLDINGS, INC.
(Exact name of Registrant as specified in its charter)

Maryland

 

33-0724736

(State or other jurisdiction of incorporation or organization)

 

(I.R.S. Employer Identification Number)

 

10 North Park Place, Suite 201, Morristown, NJ

 

07960

  (Address of principal executive offices) 

 

  (Zip Code)

(800) 793-2145
(Registrant's telephone number, including area code)

Indicate by check mark whether the Registrant (1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during the preceding 12 months (or for such shorter period that the Registrant was required to file such report(s)) and (2) has been subject to such filing requirements for the past 90 days. Yes    þ     No    o .

Indicate by check mark whether the Registrant has submitted electronically and posted on its corporate Web site, if any, every Interactive Data File required to be submitted and posted pursuant to Rule 405 of Regulation S-T (§232.405 of this chapter) during the preceding 12 months (or for such shorter period that the registrant was required to submit and post such files).  Yes    þ    No    o .

Indicate by check mark whether the Registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, or a smaller reporting company. See definitions of "large accelerated filer," "accelerated filer," and "smaller reporting company" in Rule 12b-2 of the Exchange Act.  (Check one):

Large accelerated filer

o

Accelerated filer

o

 

 

 

 

Non-accelerated filer 

o

Smaller reporting company

þ

(Do not check if a smaller reporting company)

 

 

Indicate by check mark whether the registrant is a shell company (as defined in Rule 12b-2 of the Exchange Act). YES   o     NO   þ

On November 3, 2016, there were 9,499,812 shares outstanding of the Registrant's common stock, par value $0.01 per share.



PERNIX THERAPEUTICS HOLDINGS, INC. AND SUBSIDIARIES

Quarterly Report on Form 10-Q
For the Three and Nine Months Ended September 30, 2016

INDEX

PART I. 

FINANCIAL INFORMATION

 

 

 

 

 

 

 

 

Item 1. 

Financial Statements (unaudited)

 

 

 

 

Condensed Consolidated Balance Sheets

 

 

3

 

 

Condensed Consolidated Statements of Operations

 

 

4

 

 

Condensed Consolidated Statements of Cash Flows

 

 

5

 

 

Notes to Condensed Consolidated Financial Statements

 

 

6

 

Item 2. 

Management's Discussion and Analysis of Financial Condition and Results of Operations

 

 

28

 

Item 3.

Quantitative and Qualitative Disclosures About Market Risk

 

 

41

 

Item 4.

Controls and Procedures

 

 

41

 

 

 

 

 

 

 

PART II. 

OTHER INFORMATION

 

 

 

 

 

 

 

 

 

 

Item 1. 

Legal Proceedings

 

 

42

 

Item 1A. 

Risk Factors

 

 

42

 

Item 2. 

Unregistered Sales of Equity Securities and Use of Proceeds

 

 

43

 

Item 3.

Defaults upon Senior Securities

 

 

43

 

Item 4.

Mine Safety Disclosures

 

 

43

 

Item 5.

Other Information

 

 

43

 

Item 6.  

Exhibits

 

 

44

 

 

Signatures

 

 

45

 

 

 

2


PART I.   FINANCIAL INFORMATION

Item 1. Financial Statements.

PERNIX THERAPEUTICS HOLDINGS, INC. AND SUBSIDIARIES
Condensed Consolidated Balance Sheets

(In thousands, except per share data)
(Unaudited)

      September 30,     December 31,
      2016     2015
Assets            
Current assets:            
     Cash and cash equivalents   $ 28,521    $ 56,135 
     Restricted cash         10,002 
     Accounts receivable, net     44,772      61,209 
     Inventory, net     8,282      10,035 
     Prepaid expenses and other current assets     13,256      11,574 
     Income tax receivable     3,351      6,735 
          Total current assets     98,182      155,690 
             
Property and equipment, net     1,199      2,346 
Goodwill     54,366      54,865 
Intangible assets, net     220,138      285,943 
Other     279      347 
               Total assets   $ 374,164    $ 499,191 
Liabilities and Stockholders' (Deficit) Equity            
Current liabilities:            
     Accounts payable and accrued expenses   $ 23,133    $ 27,772 
     Accrued allowances     56,355      62,678 
     Interest payable     6,618      11,903 
     Treximet Secured Notes - current     633      13,335 
     Restricted cash payable         10,002 
     Other liabilities - current     4,387      6,753 
          Total current liabilities     91,126      132,443 
             
Convertible notes - long-term     102,953      99,776 
Derivative liability     2,421      9,165 
Contingent consideration     5,097      14,055 
Treximet Secured Notes - long-term     184,002      188,715 
Credit facilities - long-term     14,000      15,000 
Deferred income tax liability - long-term     226      202 
Other liabilities - long-term     4,408      6,738 
          Total liabilities     404,233      466,094 
Commitments and contingencies (notes 1, 3, 6, 7, 10 and 11)            
Stockholders' (deficit) equity:            
     Preferred stock, $0.01 par value, authorized 10,000,000 shares; no shares issued            
          and outstanding        
     Common stock, $0.01 par value, 140,000,000 shares authorized, 9,499,812            
          and 6,387,455 issued and 9,499,812 and 6,111,253 outstanding            
          at September 30, 2016 and December 31, 2015, respectively     95      61 
     Additional paid-in capital     242,164      227,387 
     Treasury stock, at cost, 0 and 2,762,022 shares held at September 30, 2016            
          and December 31, 2015, respectively, see Note 1         (5,548)
     Accumulated other comprehensive loss     (12)    
     Accumulated deficit     (272,316)     (188,803)
          Total stockholders' (deficit) equity     (30,069)     33,097 
               Total liabilities and stockholders' (deficit) equity   $ 374,164    $ 499,191 

See accompanying notes to condensed consolidated financial statements.

3


PERNIX THERAPEUTICS HOLDINGS, INC. AND SUBSIDIARIES
Condensed Consolidated Statements of Operations

(In thousands, except per share data)
(Unaudited)

      Three Months Ended     Nine Months Ended
      September 30,     September 30,
      2016     2015     2016     2015
                         
Net revenues   $ 41,468    48,615    $ 110,683    129,481 
                         
Costs and operating expenses:                        
     Cost of product sales     10,840      12,036      34,272      36,906 
     Selling, general and administrative expense     22,173      27,419      73,615      73,262 
     Research and development expense     1,712      3,180      5,139      5,644 
     Depreciation and amortization expense     20,700      25,733      65,426      66,492 
     Change in fair value of contingent consideration     516      (3,596)     (8,958)     (3,596)
     Loss from disposal and impairments of assets     652          2,423     
     Restructuring costs     2,277      (4)     2,277      1,193 
          Total costs and operating expenses     58,870      64,768      174,194      179,901 
                         
Loss from operations     (17,402)     (16,153)     (63,511)     (50,420)
                         
Other income (expense):                        
     Interest income         43          153 
     Interest expense     (8,857)     (9,687)     (26,818)     (28,818)
     Change in fair value of derivative liability     (209)     10,527      6,744      19,230 
     Foreign currency transaction gain     31          98     
     Loss on extinguishment of debt         (1,112)         (1,112)
     Cost of inducement                 (19,500)
          Total other expense, net     (9,035)     (229)     (19,976)     (30,047)
                         
Loss before income tax expense (benefit)     (26,437)     (16,382)     (83,487)     (80,467)
Income tax expense (benefit)         (5,642)     26      (13,818)
Net loss   $ (26,438)   $ (10,740)   $ (83,513)   $ (66,649)
                         
Net loss per common share                        
     Basic   $ (2.99)   $ (1.76)   $ (11.57)   $ (13.15)
     Diluted   $ (2.99)   $ (1.76)   $ (11.57)   $ (13.15)
                         
Weighted-average common shares outstanding:                        
     Basic     8,842      6,097      7,215      5,070 
     Diluted     8,842      6,097      7,215      5,070 

   See accompanying notes to condensed consolidated financial statements.

4


PERNIX THERAPEUTICS HOLDINGS, INC. AND SUBSIDIARIES
Condensed Consolidated Statements of Cash Flows

(In thousands)
(Unaudited)

      Nine Months Ended
      September 30,
      2016     2015
Cash flows from operating activities:            
     Net loss   $ (83,513)   $ (66,649)
     Adjustments to reconcile net loss to net cash used in operating activities:            
          Depreciation     588      251 
          Amortization of intangibles     64,886      66,241 
          Amortization of deferred financing costs     1,824      1,961 
          Accretion of debt discount     2,655      1,436 
          Interest accretion of notes receivable         (127)
          Deferred income tax benefit     24      (10,159)
          Stock compensation expense     2,080      4,428 
          Fair market value change in derivative liability     (6,744)     (19,230)
          Issuance of stock for inducement         19,500 
          Fair market value change in contingent consideration     (8,958)     (3,596)
          Loss on disposal of fixed assets     35      19 
          Impairment of fixed assets and intangibles     2,388     
          (Increase) decrease in operating assets (excluding effect of acquisitions):            
               Accounts receivable     16,966      (16,461)
               Income tax receivable     3,384      (6,194)
               Inventory     1,753      (182)
               Prepaid expenses and other assets     635      3,002 
          Increase (decrease) in operating liabilities (excluding effect of acquisitions):            
               Accounts payable and accrued expenses     (7,005)     15,019 
               Accrued allowances     (6,323)     5,354 
               Interest payable     (5,285)     (2,957)
               Other liabilities     (2,280)     (2,551)
                    Net cash used in operating activities     (22,890)     (10,895)
             
Cash flows from investing activities:            
     Acquisition of Zohydro ER®          (83,341)
     Acquisition of supplier contract     (583)    
     Acquisition of TREXIMET®          (2,836)
     Payments received on notes receivable         4,850 
     Purchase of software and equipment     (964)     (1,029)
                    Net cash used in investing activities     (1,547)     (82,356)
             
Cash flows from financing activities:            
     Payments on Treximet Secured Notes     (20,406)     (10,013)
     Net (payments) drawdowns on credit facilities     (1,000)     2,655 
     Net proceeds from issuance of Convertible Notes         130,000 
     Payments for financing costs         (5,045)
     Payment of consent fee         (2,150)
     Payments on mortgages and capital leases     (50)     (28)
     Proceeds from issuance of common stock, net of tax and costs     18,303      276 
     Shares withheld for the payment of taxes     (24)     (112)
                    Net cash (used in) provided by financing activities     (3,177)     115,583 
             
                    Net (decrease) increase in cash and cash equivalents     (27,614)     22,332 
Cash and cash equivalents, beginning of period     56,135      34,855 
Cash and cash equivalents, end of period   $ 28,521    $ 57,187 

See accompanying notes to condensed consolidated financial statements.

5


PERNIX THERAPEUTICS HOLDINGS, INC. AND SUBSIDIARIES
NOTES TO CONDENSED CONSOLIDATED FINANCIAL STATEMENTS

(Unaudited)

Note 1. Company Overview

Pernix Therapeutics Holdings, Inc. and subsidiaries (collectively, "Pernix", the "Company", "we", "our" and "us") is a specialty pharmaceutical company focused on the acquisition, development and commercialization of prescription drugs, primarily for the United States ("U.S.") market. The Company targets underserved therapeutic areas, such as the central nervous system ("CNS") and Pain, including neurology, psychiatry as well as Pain specialties, and has an interest in expanding into additional specialty segments. The Company promotes its branded products to physicians through its Pernix sales force, and markets its generic portfolio through its wholly owned subsidiaries, Macoven Pharmaceuticals, LLC ("Macoven") and Cypress Pharmaceuticals, Inc. ("Cypress").

The Company's branded products include Treximet®, a medication indicated for the acute treatment of migraine attacks with and without aura, Silenor®, a non-controlled substance and approved medication for the treatment of insomnia characterized by difficulty with sleep maintenance and Zohydro ER® with BeadTek, an extended-release opioid agonist indicated for the management of pain severe enough to require daily, around-the-clock, long-term opioid treatment and for which alternative treatment options are inadequate.

The accompanying unaudited condensed consolidated financial statements included herein have been prepared by the Company in accordance with generally accepted accounting principles in the United States ("GAAP") and under the rules and regulations of the United States Securities and Exchange Commission (SEC) for interim reporting. In management's opinion, the interim financial data presented includes all adjustments (consisting solely of normal recurring items) necessary for fair presentation. All intercompany accounts and transactions have been eliminated. Certain information required by GAAP has been condensed or omitted in accordance with rules and regulations of the SEC. Operating results for the three and nine months ended September 30, 2016 are not necessarily indicative of the results that may be expected for any future period or for the year ending December 31, 2016.

These unaudited condensed consolidated financial statements should be read in conjunction with the Company's audited consolidated financial statements and the notes thereto for the year ended December 31, 2015, included in Pernix Therapeutics' 2015 Annual Report on Form 10-K filed with the SEC.

The preparation of the unaudited condensed consolidated financial statements requires management to make estimates and assumptions relating to reporting of the assets and liabilities and the disclosure of contingent assets and liabilities to prepare these unaudited condensed consolidated financial statements and the reported amounts of revenues and expenses during the reporting period in conformity with GAAP. Significant estimates of the Company include: revenue recognition, sales allowances such as returns on product sales, government program rebates, customer coupon redemptions, wholesaler/pharmacy discounts, product service fees, rebates and chargebacks, sales commissions, amortization, stock-based compensation, the determination of fair values of assets and liabilities in connection with business combinations, and deferred income taxes. Actual results could differ from these estimates.

Subsequent Events

The Company has evaluated all events and transactions since September 30, 2016.

The Company had the following non-recognized subsequent event:

On November 1, 2016, the Company made the decision that it would not be exercising its option to obtain an exclusive, royalty-bearing license to the Altus Technology and the Altus Product Technology, as defined in the Development and Option Agreement dated November 1, 2013 between Zogenix, Inc. and Altus Formulation, Inc. The decision was made based on a careful evaluation of the Development and Option Agreement and the potential alternative technologies available to Pernix. The Company remains committed to continuing to improve the abuse-deterrent properties of Zohydro ER by investing in innovative technologies for future development of the product, including a reformulation of Zohydro ER with BeadTek and/or the license, development and commercialization of other abuse-deterrent technologies. The Company anticipates recording approximately $4.2 million as an impairment charge during the fourth quarter of 2016.

The Company had the following recognized subsequent event:

On October 13, 2016, the Company filed Articles of Amendment to its charter (the "Articles of Amendment"), with the State Department of Assessments and Taxation of Maryland to effect a one-for-ten reverse stock split of the outstanding shares of common stock, par value $0.01 per share, of the Company (the "Reverse Stock Split"). The Reverse Stock Split was duly approved by the Board of Directors of the Company without stockholder approval in accordance with the authority conferred by Section 2-309(e)(2) of the Maryland General Corporation Law and Article IV, Section 6 of the Company's charter. Pursuant to the Articles of Amendment, effective as of the close of business on October 13, 2016, each outstanding share of the Company's common stock, par value $0.01 per share, was automatically combined into 1/10 th  of share of common stock, par value $0.01 per share. Fractional share holdings were rounded up to the nearest whole number. As a result of the Reverse Stock Split, the number of outstanding shares of common stock of the Company was reduced to approximately 9.5 million shares.

6


Each stockholder's percentage ownership in the Company and proportional voting power remained unchanged immediately after the Reverse Stock Split, except for minor changes resulting from the rounding up of fractional shares. The rights and privileges of stockholders were also unaffected by the Reverse Stock Split. There was no change to the number of authorized shares of the Company's common stock as a result of the Reverse Stock Split. Accordingly, all share and per share information in this Report has been restated to retroactively show the effect of the Reverse Stock Split.

Acquisition of Zohydro ER with BeadTek

On April 24, 2015, the Company, through a wholly owned subsidiary Pernix Ireland Pain Limited ("PIPL") completed the acquisition of the pharmaceutical product line Zohydro ER, including an abuse-deterrent pipeline and all related intellectual property, a supplier contract, an associated liability payable and a specified quantity of inventory associated therewith, from Zogenix, Inc. ("Zogenix"). See Note 12, Business Combinations,  for further discussion.

Reclassifications

Certain comparative figures have been reclassified to conform to the current year presentation. The Company reclassified the $5.6 million of outstanding treasury stock from Treasury stock to Common stock and Additional paid-in capital at September 30, 2016. Also, in accordance with Accounting Standards Update ("ASU") 2015-03, Simplifying the Presentation of Debt Issuance Costs , ("ASU 2015-03"), the Company reclassified $1.7 million from Prepaid expenses and other current assets to Treximet Secured Notes - current, $4.0 million from Other assets to Convertible notes - long-term and $6.2 million from Other assets to Treximet Secured Notes - long-term on the unaudited condensed consolidated balance sheet at December 31, 2015.

Principles of Consolidation

The unaudited condensed consolidated financial statements include the accounts of Pernix's wholly-owned subsidiaries Pernix Therapeutics, LLC, Macoven, Cypress, Cypress' subsidiary, Hawthorn Pharmaceuticals, Inc., Pernix Ireland Limited and Pernix Ireland Pain Limited. Transactions between and among the Company and its consolidated subsidiaries are eliminated.

Fair Value of Financial Instruments

A financial instrument is defined as cash equivalent, evidence of an ownership interest in an entity, or a contract that creates a contractual obligation or right to deliver or receive cash or another financial instrument from another party. The Company's financial instruments consist primarily of cash equivalents, notes receivable, and a credit facility. The carrying values of these assets and liabilities approximate their fair value due to their short-term nature.

Significant Customers

The Company's customers consist of drug wholesalers, retail drug stores, mass merchandisers and grocery store pharmacies in the United States. The Company primarily sells its products directly to large national drug wholesalers, which in turn resell the products to smaller or regional wholesalers, retail pharmacies, chain drug stores, and other third parties.  The following tables list the Company's customers that individually comprised greater than 10% of total gross product sales for the three and nine months ended September 30, 2016 and 2015, or 10% of total accounts receivable as of September 30, 2016 and December 31, 2015.

7


Gross Product Sales:                        
      Three Months Ended     Nine Months Ended
      September 30,     September 30,
      2016     2015     2016     2015
                         
McKesson Corporation     34%     38%     35%     40%
AmerisourceBergen Drug Corporation     31%     27%     32%     25%
Cardinal Health, Inc.     26%     28%     26%     28%
     Total     91%     93%     93%     93%

 

Accounts Receivable, net:            
      September 30,     December 31,
      2016     2015
             
McKesson Corporation     32%     34%
Cardinal Health, Inc.     30%     28%
AmerisourceBergen Drug Corporation     30%     30%
     Total     92%     92%

Note 2. Earnings per Share

Basic net income (loss) per common share is the amount of net income (loss) for the period divided by the weighted average shares of common stock outstanding during the reporting period. Diluted income (loss) per common share is the amount of income (loss) for the period plus interest expense on convertible debt divided by the sum of weighted average shares of common stock outstanding during the reporting period and weighted average shares that would have been outstanding assuming the issuance of common shares for all dilutive potential common shares.

The following table sets forth the computation of basic and diluted net loss per share (in thousands except per share data):

      Three Months Ended     Nine Months Ended
      September 30,     September 30,
      2016     2015     2016     2015
Numerator:                        
     Net loss   $ (26,438)   $ (10,740)   $ (83,513)   $ (66,649)
                         
Denominator:                        
Weighted-average common shares, basic     8,842      6,097      7,215      5,070 
     Dilutive effect of stock options     -       -       -       -  
Weighted-average common shares, diluted     8,842      6,097      7,215      5,070 
                         
Net loss per share, basic and diluted   $ (2.99)   $ (1.76)   $ (11.57)   $ (13.15)

8


The following table sets forth the potential common shares that could potentially dilute basic income per share in the future that were not included in the computation of diluted income (loss) per share because to do so would have been anti-dilutive for the periods presented (in thousands):

      Three Months Ended     Nine Months Ended
      September 30,     September 30,
      2016     2015     2016     2015
4.25% Convertible Notes     1,133      1,133      1,133      673 
8.00% Convertible Notes     -       -       -       734 
Stock options and restricted stock     696      426      805      371 
Warrants     33      -       33      -  
Total potential dilutive effect     1,862      1,559      1,971      1,778 

Note 3. Fair Value Measurement

The Company's financial assets and liabilities are measured using inputs from the three levels of the fair value hierarchy. The three levels are as follows:

Level 1- Inputs are unadjusted quoted prices in active markets for identical assets or liabilities that the Company has the ability to access at the measurement date.

Level 2- Inputs are other than quoted prices included within Level 1 that are observable for the asset or liability, either directly or indirectly. Level 2 inputs include quoted prices for similar assets and liabilities in active markets, quoted prices for identical or similar assets or liabilities in markets that are not active, inputs other than quoted prices that are observable for the asset or liability (i.e., interest rates, yield curves, etc.), and inputs that are derived principally from or corroborated by observable market data by correlation or other means (market corroborated inputs).

Level 3- Inputs are unobservable and reflect the Company's assumptions that market participants would use in pricing the asset or liability. The Company develops these inputs based on the best information available.

Summary of Assets Recorded at Fair Value

In accordance with the fair value hierarchy described above, the following table shows the fair value of the Company's financial assets that are required to be measured at fair value as of September 30, 2016 and December 31, 2015 (in thousands):

      As of September 30, 2016
      Level 1     Level 2     Level 3     Total
Money market fund and trust cash sweep investments (1)   $ -     $ -     $ -     $ -  
     Total assets   $ -     $ -     $ -     $ -  
                         
      As of December 31, 2015
      Level 1     Level 2     Level 3     Total
Money market fund and trust cash sweep investments (1)   $ 4,367    $ -     $ -     $ 4,367 
     Total assets   $ 4,367    $ -     $ -     $ 4,367 

 

(1)

The Company's money market and trust cash sweep investments are included in cash and cash equivalents within the Unaudited Condensed Consolidated Balance Sheets.

 

9


The Company's cash equivalents are classified within Level 1 of the fair value hierarchy because they are valued using quoted market prices or broker or dealer quotations for similar assets. These investments are initially valued at the transaction price and subsequently valued utilizing third-party pricing providers or other market observable data. Data used in the analysis include reportable trades, broker/dealer quotes, bids and offers, benchmark yields and credit spreads. The Company validates the prices provided by its third-party pricing providers by reviewing their pricing methods, analyzing pricing inputs and confirming that the securities have traded in normally functioning markets. The Company did not adjust or override any fair value measurements provided by its pricing providers as of September 30, 2016 or December 31, 2015.

As of September 30, 2016 and December 31, 2015, the Company did not have any investments in Level 2 or Level 3 securities.

There were no transfers of assets or liabilities between Level 1 and Level 2 during the three and nine months ended September 30, 2016 and 2015.

The carrying amounts reflected in the unaudited condensed consolidated balance sheets for certain short-term financial instruments including accounts receivable, accounts payable, accrued expenses, and other liabilities approximate fair value due to their short-term nature.

Summary of Liabilities Recorded at Carrying Value and Fair Value

The 4.25% Convertible Notes and the Treximet Secured Notes are recorded at carrying value. The derivative liability and contingent consideration are recorded at fair value. Within the hierarchy of fair value measurements, the derivative liability and contingent consideration are Level 3 fair values. The fair and carrying value of our debt instruments are detailed as follows (in thousands):

            As of September 30, 2016     As of December 31, 2015
            Fair     Carrying     Fair     Carrying
            Value     Value     Value     Value
4.25% Convertible Notes         $ 31,350    $ 102,953    $ 68,637    $ 99,776 
Derivative liability           2,421      2,421      9,165      9,165 
Contingent consideration           5,097      5,097      14,055      14,055 
Treximet Secured Notes           144,797      184,635      179,518      202,050 
     Total         $ 183,665    $ 295,106    $ 271,375    $ 325,046 

Convertible Notes

The fair values of the Convertible notes were estimated using the (i) terms of the convertible notes; (ii) rights, preferences, privileges, and restrictions of the underlying security; (iii) time until any restriction(s) are released; (iv) fundamental financial and other characteristics of the Company; (v) trading characteristics of the underlying security (exchange, volume, price, and volatility); (vi) valuation of derivative liability; and (vii) precedent sale transactions.

Derivative Liability

The fair value of the derivative liability was determined using a "with and without" scenario. Under this methodology, valuations are performed on the convertible note inclusive of all terms as well as for a convertible note that has identical terms and features but excluding the conversion option. The difference between the two valuations is equal to the fair value of the conversion option. Significant increases or decreases in these inputs would result in a significant change in the fair value of the derivative liability.

10


Contingent Consideration

The fair value of contingent consideration is based on two components - a regulatory milestone and commercial milestone.

For the regulatory milestone, the expected regulatory earn out payment was discounted taking into account (a) the Company's cost of debt, (b) the expected timing of the payment and (c) subordinate nature of the earn out obligation.

The fair value of the commercial milestone was determined using a Monte Carlo simulation. This simulation assumed a risk-neutral framework, whereby future net revenue was simulated over the earn out period using the Geometric Brownian Motion. For each simulation path, the earn out payments were calculated based on the achievement of the revenue milestone and then were discounted to the valuation date. Significant increases or decreases in these unobservable inputs and/or the probability of achievement of these milestones would result in a significant change in the fair value of the contingent consideration.

Treximet Secured Notes

The fair value of the Company's Treximet Secured Notes was estimated using a discounted cash flow model.

Fair Value Measurements Using Significant Unobservable Inputs (Level 3)

For the Company's assets and liabilities measured at fair value on a recurring basis using significant unobservable inputs (Level 3), the following table provides a reconciliation of the beginning and ending balances for each category therein, and gains or losses recognized during the periods (in thousands).

      As of and for the     As of and for the
      Nine months Ended     Year Ended
      September 30, 2016     December 31, 2015
Derivative liability:            
Balance at beginning of year   $ 9,165    $ -  
     Initial measurement of derivative liability     -       28,480 
     Remeasurement adjustments - gains included in earnings     (6,744)     (19,315)
Ending balance   $ 2,421    $ 9,165 
             
Contingent consideration:            
Balance at beginning of year   $ 14,055    $ -  
     Initial measurement of contingent consideration     -       14,193 
     Remeasurement adjustments - gains included in earnings     (8,958)     (138)
Ending balance   $ 5,097    $ 14,055 

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Note 4. Inventory

Inventories are stated at the lower of cost or market. Inventories consist of the following (in thousands):

      September 30,     December 31,
      2016     2015
Raw materials   $ 1,506    $ 2,047 
Work-in-process         1,425 
Finished goods     9,732      9,011 
Inventory, gross     11,238      12,483 
Reserve for obsolescence     (2,956)     (2,448)
     Inventory, net   $ 8,282    $ 10,035 

Note 5. Goodwill and Intangible Assets

Goodwill consists of the following (in thousands):

      Amount
Balance at December 31, 2014   $ 44,900 
     Goodwill acquired - Zohydro ER     180 
     Measurement period adjustments - Zohydro ER     6,949 
     Measurement period adjustments - Treximet     2,836 
Balance at December 31, 2015     54,865 
     Measurement period adjustments - Zohydro ER     (499)
Balance at September 30, 2016   $ 54,366 

Intangible assets consist of the following (dollars in thousands):

            As of September 30, 2016
      Weighted     Gross Carrying           Accumulated     Net Carrying
      Average Life     Amount     Impairment     Amortization     Amount
Unamortized intangible assets:                              
     In-process research and development     Indefinite   $ 26,500    $ -     $ -     $ 26,500 
Total unamortized intangible assets           26,500      -       -       26,500 
                               
Amortized intangible assets:                              
     Brand     0.0 years     891      (891)     -       -  
     Product licenses     8.4 years     2,846      -       (1,141)     1,705 
     Supplier contracts     5.0 years     583      -       (49)     534 
     Acquired developed technologies     7.7 years     376,237      (611)     (184,227)     191,399 
Total amortized intangible assets           380,557      (1,502)     (185,417)     193,638 
                               
Total intangible assets         $ 407,057    $ (1,502)   $ (185,417)   $ 220,138 

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            As of December 31, 2015
      Weighted     Gross Carrying           Accumulated     Net Carrying
      Average Life     Amount     Impairment     Amortization     Amount
Unamortized intangible assets:                              
     Trademark rights     Indefinite    $ 400    $ (400)   $ -     $ -  
     In-process research and development     Indefinite     29,500      (3,000)     -       26,500 
Total unamortized intangible assets           29,900      (3,400)     -       26,500 
                               
Amortized intangible assets:                              
     Patents     11.0 years     500      (106)     (394)     -  
     Brand     8.0 years     3,887      -       (2,794)     1,093 
     Product licenses     10.5 years     17,581      (10,059)     (5,542)     1,980 
     Non-compete and supplier contracts     5.6 years     6,337      -       (6,337)     -  
     Acquired developed technologies     4.1 years     391,624      (10,787)     (124,467)     256,370 
Total amortized intangible assets           419,929      (20,952)     (139,534)     259,443 
                               
Total intangible assets         $ 449,829    $ (24,352)   $ (139,534)   $ 285,943 

As of September 30, 2016, the weighted average remaining life for our definite-lived intangible assets in total was approximately 8.0 years.

In connection with the Zohydro ER acquisition (see Note 12,  Business Combinations,  for further information), the Company recorded, at fair value, intangible assets consisting of intellectual property valued at $98.8 million and in-process research and development ("IPR&D") intangibles valued at $4.2 million.  Intellectual property will be amortized on a straight-line basis over 18.3 years. IPR&D will be amortized on a straight-line basis over its useful life once the receipt of regulatory approval is obtained.

During 2016, the Company recorded impairment charges of approximately $891,000 against acquired brands and approximately $611,000 against acquired developed technologies. This impairment during the nine months ended September 30, 2016 was due to a review of the Company's product portfolio which resulted in the discontinuation of products that were not profitable. During 2015, the Company recorded impairment charges of approximately $400,000 against trademark rights, $3.0 million against IPR&D, $106,000 against patents, $10.1 million against product licenses and $10.8 million against acquired developed technologies. The Company decided during the year ended December 31, 2015 to focus its efforts on certain core products and no longer promote certain other products which are not aligned with this business strategy or due to the termination of certain contractual agreements.

Estimated amortization expense related to intangible assets with definite lives for each of the five succeeding years and thereafter is as follows (in thousands):

      Amount
2016 (October - December)   $ 20,626 
2017     80,835 
2018     15,608 
2019     6,324 
2020     6,237 
Thereafter     64,008 
Total   $ 193,638 

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Amortization expense was $20.6 million and $64.9 million for the three and nine months ended September 30, 2016, respectively, of which, $48,000 is included in cost of product sales in the unaudited condensed consolidated statements of operations. Amortization expense was $25.6 million and $66.2 million for the three and nine months ended September 30, 2015, respectively.

Note 6. Accrued Allowances

Accrued allowances consist of the following (in thousands):

      September 30,     December 31,
      2016     2015
Accrued returns allowance   $ 16,368    $ 11,896 
Accrued price adjustments     33,124      44,100 
Accrued government program rebates     6,863      6,682 
     Total   $ 56,355    $ 62,678 

Note 7. Debt 

Debt, net of discounts and deferred financing costs, consists of the following (in thousands):

      September 30,     December 31,
      2016     2015
Wells Fargo Credit Facility   $ 14,000    $ 15,000 
4.25% Convertible Notes     102,953      99,776 
Treximet Secured Notes     184,635      202,050 
     Total outstanding debt     301,588      316,826 
Less current portion     633      13,335 
     Long-term debt outstanding   $ 300,955    $ 303,491 

Credit Facilities :

Wells Fargo

On August 21, 2015, the Company entered into a Credit Agreement with Wells Fargo, National Association, as Administrative Agent and the lenders party thereto for a $50.0 million, three-year senior secured revolving credit facility (the "Wells Fargo Credit Facility"), which may be increased by an additional $20.0 million in the lenders' discretion.

The Company's obligations under the Wells Fargo Credit Facility are secured by, among other things, the Company's and certain subsidiaries' inventory and accounts receivable, and are guaranteed by certain of the Company's subsidiaries. As of September 30, 2016 and December 31, 2015, $14.0 million and $15.0 million, respectively, were outstanding under the Wells Fargo Credit Facility and classified as Credit facilities - long-term on the unaudited condensed consolidated balance sheets. Availability of borrowings under the Wells Fargo Credit Facility from time to time is subject to a borrowing base calculation based upon a valuation of the Company's eligible inventories and eligible accounts receivable, each multiplied by an applicable advance rate. Borrowing availability under the Wells Fargo Credit Facility was $11.4 million as of September 30, 2016. Borrowings under the Wells Fargo Credit Facility will bear interest at the Company's election at (i) the rate of LIBOR plus 1.5% to LIBOR plus 2.0% or (ii) the Base Rate (as defined in the Wells Fargo Credit Facility) plus 0.5% to the Base Rate plus 1.0%. The applicable interest rate margin percentage will be determined by the average daily availability of borrowings under the Wells Fargo Credit Facility. In addition, the Company is required to pay a commitment fee on the undrawn commitments under the Wells Fargo Credit Facility from time to time at an applicable rate of 0.25% per annum according to the average daily balance of borrowings under the Wells Fargo Credit Facility during any month. The Wells Fargo Credit Facility contains representations and warranties, affirmative, restrictive and financial covenants, and events of default (applicable to the Company and certain of its subsidiaries) which are customary for credit facilities of this type. The effective interest rate was 3.6% at September 30, 2016.

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MidCap Funding V, LLC

On August 21, 2015, the Company terminated the Amended and Restated Credit Agreement, dated as of May 8, 2013, as amended, by and among MidCap Funding IV, LLC, and certain subsidiaries of the Company and repaid all outstanding loans thereunder (the "MidCap Credit Facility"). The MidCap Credit Facility provided for a $20.0 million revolving loan commitment and a $20.0 million uncommitted accordion feature. The obligations under the MidCap Credit Facility were secured by a first priority security interest in the Company's accounts, inventory, deposit accounts, securities accounts, securities entitlements, permits and cash and bore interest at a rate equal to the sum of the LIBOR (with a floor of 1.5%) plus an applicable margin of 7.50% per annum. The MidCap Credit Facility has been closed and has been replaced with the Wells Fargo Credit Facility.

Convertible Notes:

4.25% Convertible Notes

On April 22, 2015, the Company issued $130.0 million aggregate principal amount 4.25% Convertible Senior Notes (the "4.25% Convertible Notes"). The 4.25% Convertible Notes mature on April 1, 2021, unless earlier converted, redeemed or repurchased. The Company received net proceeds from the sale of the 4.25% Convertible Notes of $125.0 million, after deducting placement agent fees and commissions and offering expenses payable by the Company. Interest on the 4.25% Convertible Notes is payable on April 1 and October 1 of each year, beginning October 1, 2015. The discounted note balance of $106.5 million and $103.8 million is recorded as long-term debt on the unaudited condensed consolidated balance sheet as of September 30, 2016 and December 31, 2015, respectively.

The 4.25% Convertible Notes are governed by the terms of an indenture (the "Indenture"), between the Company and Wilmington Trust, National Association (the "Trustee"), each of which were entered into on April 22, 2015.

The Company may not redeem the 4.25% Convertible Notes prior to April 6, 2019. However, the holders may convert their 4.25% Convertible Notes at any time prior to the close of business on the business day immediately preceding January 1, 2021 only under certain circumstances. Upon conversion, the Company will deliver a number of shares of the Company's common stock equal to the conversion rate in effect on the conversion date. Effective upon the Reverse Stock Split, the conversion rate decreased from 87.2030 shares of the Company's common stock for each $1,000 principal amount of the 4.25% Convertible Notes to 8.7237 shares of the Company's common stock for each $1,000 principal amount of the 4.25% Convertible Notes, which represents a conversion price of approximately $114.63 per share. Following certain corporate transactions that can occur on or prior to the stated maturity date, the Company will increase the conversion rate for a holder that elects to convert its 4.25% Convertible Notes in connection with such a corporate transaction. In addition to the holder option to convert, the 4.25% Convertible Notes may be redeemed upon the occurrence of certain events. The Company incurred debt issuance costs of approximately $5.0 million, which have been deferred and which are being amortized over a six-year period, unless earlier converted, in which case the unamortized costs would be recorded in additional paid-in capital. The effective interest rate on the 4.25% Convertible Notes, including debt issuance costs and bifurcated conversion option derivative (discussed below), is 9.7%.

The Company is required to separate the conversion option in the 4.25% Convertible Notes under ASC 815, Derivatives and Hedging . During April 2015, the Company recorded the bifurcated conversion option valued at $28.5 million as a derivative liability, which created a discount on the debt. The derivative liability is marked to market through the other income (expense) section on the unaudited condensed consolidated statements of operations for each reporting period, while the discount created on the 4.25% Convertible Notes is accreted as interest expense over the life of the debt. The derivative liability is valued at $2.4 million and $9.2 million as of September 30, 2016 and December 31, 2015, respectively. If the Company obtains shareholder approval to remove the contractual limit on the number of shares that may be delivered to settle the conversion of the 4.25% Convertible Notes, the conversion feature may meet an exception from derivative accounting and no longer require separate accounting as a bifurcated derivative. As the conversion feature is accounted for as a bifurcated derivative liability, the Company was not required to consider whether the cash conversion or beneficial conversion guidance contained in ASC 470-20, Debt with Conversion and Other Options , is applicable to the 4.25% Convertible Notes.

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In addition to the bifurcated conversion feature, there are two other features that require bifurcation but contain de minimis value. Although the probability was considered remote, at the time of the transaction, that (1) additional interest would be incurred for failure to file financial statements timely or (2) the 4.25% Convertible Notes would be redeemed by the Company following the failure of the Zohydro ER acquisition to close prior to July 8, 2015. The Company will continue to monitor the timely filing of its financial statements for any additional interest that could be incurred.

Interest expense was $2.3 million and $6.8 million for the three and nine months ended September 30, 2016, respectively and $2.2 million and $3.9 million for the three and nine months ended September 30, 2015, respectively, related to the 4.25% Convertible Notes. Change in fair value of derivative liability was an expense of $209,000 and income of $6.7 million for the three and nine months ended September 30, 2016, respectively and income of $10.5 million and $19.2 million for the three and nine months ended September 30, 2015. Accrued interest on the 4.25% Convertible Notes was approximately $2.8 million and $1.4 million as of September 30, 2016 and December 31, 2015, respectively. The Company recorded debt issuance costs of $5.0 million, which are being amortized using the effective interest method. As of September 30, 2016, $688,000 and $3.5 million are recorded on the unaudited condensed consolidated balance sheet in Prepaid expenses and other current assets and Convertible Notes - long-term, respectively, in accordance with ASU 2015-03. As of September 30, 2016 and December 31, 2015, the Company had outstanding borrowings of $130.0 million related to the 4.25% Convertible Notes, respectively.

8.00% Convertible Notes

On April 16, 2015, the Company entered into an agreement (the "Inducement Agreement") with all of the holders of its 8.00% Convertible Senior Notes due 2019 (the "8.00% Convertible Notes") representing $65.0 million aggregate principal amount, pursuant to which such holders agreed to the removal of substantially all of the material restrictive covenants in the indenture governing the 8.00% Convertible Notes and to convert their notes in accordance with the provisions of such indenture in exchange for an aggregate of 233,813 shares of the Company's common stock (the "Inducement Shares"). The Company recorded $19.5 million as cost of inducement expense in the three and nine months ended September 30, 2015. The issuance of the Inducement Shares was made pursuant to an exemption from the registration requirements of the Securities Act contained in Section 4(a)(2). Each of the holders entering into the Inducement Agreement agreed not to sell the shares of our common stock to be issued to it upon conversion of the 8.00% Convertible Notes for 145 days (the "lock-up period") subject to exceptions, including in connection with settling existing short positions with respect to the 8.00% Convertible Notes and underwritten public offerings pursuant to existing registration rights with respect to such shares of our common stock. In addition, such holders are permitted to dispose of up to 80 percent of such shares of our common stock remaining after settling existing short positions prior to the end of the lock-up period in specified intervals.

During the year ended December 31, 2015, the holders of the 8.00% Convertible Notes converted the outstanding notes at a conversion price of $36.00 per share. The Company issued 1.8 million shares pursuant to this conversion and retired the $65.0 million of the outstanding 8.00% Convertible Notes.

Interest expense was $0 for the three and nine months ended September 30, 2016 and $0 and $1.6 million for the three and nine months ended September 30, 2015, respectively related to the 8.00% Convertible Notes. As of September 30, 2016 and December 31, 2015, the Company had no outstanding borrowings related to the 8.00% Convertible Notes. Interest expense of $547,000 that accrued during the three and nine months ended September 30, 2015 was forfeited and recorded in additional paid-in capital. During the year ended December 31, 2015, the Company recorded the remaining $5.4 million unamortized deferred financing costs related to the 8.00% Convertible Notes in additional paid-in capital.

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Secured Notes:

Treximet Note Offering

On August 19, 2014, the Company issued $220.0 million aggregate principal amount of its 12% Senior Secured Notes due 2020 (the "Treximet Secured Notes") pursuant to an Indenture (the "August 2014 Indenture") dated as of August 19, 2014 among the Company, certain of its subsidiaries (the "Guarantors") and U.S. Bank National Association (the "August 2014 Trustee"), as trustee and collateral agent.

The Treximet Secured Notes mature on August 1, 2020 and bear interest at a rate of 12% per annum, payable in arrears on February 1 and August 1 of each year (each, a "Payment Date"), beginning on February 1, 2015. On each Payment Date, commencing August 1, 2015, the Company began paying installments of principal of the Treximet Secured Notes in an amount equal to 50% of net sales of Treximet for the two consecutive fiscal quarters immediately preceding such Payment Date (less the amount of interest paid on the Treximet Secured Notes on such Payment Date). At each month-end beginning with January 2015, the net sales of Treximet will be calculated, the monthly interest accrual amount will then be deducted from the net sales and this resulting amount will be recorded as the current portion of the Treximet Secured Notes. If the Treximet net sales less the interest due at each month-end of each six-month period does not result in any excess over the interest due, no principal payment must be paid at that time. The remaining balance outstanding on the Treximet Secured Notes will be due on the maturity date, which is August 1, 2020. As of September 30, 2016 and December 31, 2015, the Company classified $633,000 and $15.0 million, respectively, of the Treximet Secured Notes as a current liability and $189.0 million and $194.9 million as a non-current liability, respectively.

The Treximet Secured Notes are unconditionally guaranteed, jointly and severally, by the Guarantors. The Treximet Secured Notes and the guarantees of the Guarantors are secured by a continuing first-priority security interest in substantially all of the assets of the Company and the Guarantors related to Treximet other than inventory and certain inventory related assets, including accounts arising from the sale of the inventory.

The Company may redeem the Treximet Secured Notes at its option, in whole at any time or in part from time to time, on any business day, on not less than 30 days nor more than 60 days prior notice provided to each holder's registered address. If such redemption was prior to August 1, 2015, the redemption price would have been equal to the greater of (i) the principal amount of the Treximet Secured Notes being redeemed and (ii) the present value, discounted at the applicable treasury rate of the principal amount of the Treximet Secured Notes being redeemed plus 1.00%, of such principal payment amounts and interest at the rate per annum shown above on the outstanding principal balance of the Treximet Secured Notes being redeemed assuming the principal balances were amortized at the times and in the assumed amounts set forth on Schedule A to the August 2014 Indenture. If such redemption occurs (i) on or after August 1, 2016 and prior to August 1, 2017, the redemption price will equal 103% of the outstanding principal amount of the August Notes being redeemed plus accrued and unpaid interest thereon and (ii) on or after August 1, 2017, the redemption price will equal 100% of the outstanding principal amount of the Treximet Secured Notes being redeemed plus accrued and unpaid interest thereon.

The August 2014 Indenture contains covenants that limit the ability of the Company and the Guarantors to, among other things: incur certain additional indebtedness; pay dividends on, redeem or repurchase stock or make other distributions in respect of its capital stock; repurchase, prepay or redeem certain indebtedness; make certain investments; create restrictions on the ability of the Guarantors to pay dividends to the Company or make other intercompany transfers; create liens; transfer or sell assets; consolidate, merge or sell or otherwise dispose of all or substantially all of its assets and enter into certain transactions with affiliates. Upon the occurrence of certain events constituting a change of control, the Company is required to make an offer to repurchase all of the Treximet Secured Notes (unless otherwise redeemed) at a purchase price equal to 101% of their principal amount, plus accrued and unpaid interest, if any to the repurchase date.

17


The August 2014 Indenture provides that an Event of Default (as defined in the August 2014 Indenture) will occur if, among other things, (a) the Company defaults in any payment of interest on any note when due and payable, and such default continues for a period of 30 days; (b) the Company defaults in the payment of principal of or premium, if any, on any note when due and payable on the maturity date, upon declaration of acceleration or otherwise, or to pay the change of control repurchase price, when due and payable, and such default continues for a period of five days; (c) failure to make a repurchase offer in the event of a change in control when required under the August 2014 Indenture, which continues for three business days; (d) the Company or any Guarantor fails to comply with certain covenants after receiving written notice from the August 2014 Trustee or the holders of more than 25% of the principal amount of the outstanding Treximet Secured Notes; (e) the Company or any Guarantor defaults with respect to other indebtedness for borrowed money in excess of $8.0 million and such default is not cured within 30 days after written notice from the August 2014 Trustee or the holders of more than 25% of the principal amount of the outstanding Treximet Secured Notes; (f) the Company or any Guarantor has rendered against it a final judgment for the payment of $8.0 million (or its foreign currency equivalent) or more (excluding any amounts covered by insurance) under certain circumstances; (g) certain bankruptcy, insolvency, liquidation, reorganization or similar events occur with respect to the Company or any Guarantor; (h) a guarantee of the Treximet Secured Notes (with certain exceptions) is held to be unenforceable or invalid in a judicial proceeding or ceases to be in full force and effect or a Guarantor disaffirms its obligations under its guarantee of the Treximet Secured Notes; and (i) certain changes in control of a Guarantor.

Interest expense related to the Treximet Secured Notes was $5.7 million and $17.6 million, for the three and nine months ended September 30, 2016, respectively and $6.4 million and $19.6 million for the three and nine months ended September 30, 2015, respectively. Accrued interest on the Treximet Secured Notes was approximately $3.8 million and $10.5 million as of September 30, 2016 and December 31, 2015, respectively. The Company recorded debt issuance costs of $7.8 million, which are being amortized using the effective interest method. As of September 30, 2016, $1.3 million and $3.8 million are recorded on the unaudited condensed consolidated balance sheet in Prepaid expenses and other current assets and Treximet Secured Notes - long-term, respectively, in accordance with ASU 2015-03.

On April 13, 2015, the Company furnished to the holders of the Treximet Secured Notes a Consent Solicitation Statement (the "Consent Solicitation"). The Consent Solicitation sought the consent of the holders of a majority of the principal amount of the Treximet Secured Notes to amend the Indenture, dated August 19, 2014 (the "Indenture"), among the Company, certain subsidiaries of the Company, as guarantors, and U.S. Bank National Association, that governs the Treximet Secured Notes to allow the Company to, among other things, incur up to $42.2 million of additional debt (the "Indenture Amendments") in exchange for a consent fee in cash equal to 1% of the principal amount of consenting Treximet Secured Notes (the "Consent Fees"). Through April 28, 2015, the Company received consent to the Indenture Amendments from holders representing approximately 98% of the principal amount of the Notes, and subsequently paid the holders approximately $2.2 million during the year ended December 31, 2015. The cost of inducement of $403,000 and $1.2 million is recorded in Prepaid expenses and other current assets and Treximet Secured Notes - long-term, respectively, in accordance with ASU 2015-03, on the unaudited condensed consolidated balance sheet at September 30, 2016 and are being amortized using the effective interest method.

18


The following table represents the future maturity schedule of the outstanding debt and line of credit at September 30, 2016 (in thousands):

    
      Amount
2016   $ -  
2017     633 
2018     14,000 
2019     -  
2020     188,948 
Thereafter     130,000 
     Total maturities     333,581 
Less:      
     Note discount     (23,539)
     Deferred financing costs     (8,454)
Total outstanding debt   $ 301,588 

Note 8. Stockholders' Equity 

Reverse Stock Split

On October 13, 2016, the Company effectuated a reverse stock split of its outstanding shares of common stock at a ratio of 1 to 10. Upon the effectiveness of the Reverse Stock Split, which occurred on October 13, 2016, the Company's issued and outstanding shares of common stock was decreased from 94,961,549 to 9,499,812 shares, all with a par value of $0.01. Accordingly, all share and per share information has been restated in the Report to retroactively show the effect of the Reverse Stock Split.

Controlled Equity Offering

On November 7, 2014, the Company entered into a controlled equity offering sales agreement (the "Sales Agreement") with Cantor Fitzgerald & Co. ("Cantor") pursuant to which the Company could issue and sell shares of its common stock having an aggregate offering price of up to one hundred million dollars, pursuant to an effective registration statement on Form S-3 (No. 333-200005), from time to time through Cantor, acting as agent. The Company will pay Cantor a commission rate of 3.0% of the gross sales price per share of the common stock sold through Cantor as agent under the Sales Agreement.

During the three months ended September 30, 2016, the Company sold 984,148 shares of common stock under the Sales Agreement at an average price of approximately $6.56 per share for gross proceeds of $6.5 million and net proceeds of $6.2 million, after deducting Cantor's commission. During the nine months ended September 30, 2016, the Company sold 3,376,284 shares of common stock under the Sales Agreement at an average price of approximately $5.59 per share for gross proceeds of $18.9 million and net proceeds of $18.3 million, after deducting Cantor's commission. As of September 30, 2016, approximately $81.1 million of common stock remained available to be sold under this facility.

Warrants

As of September 30, 2016, the Company has approximately 32,992 outstanding common stock warrants in connection with the acquisition of Somaxon in March 2013.

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Stock Option Plans

In June 2015, the Company's shareholders approved the 2015 Omnibus Incentive Plan (the "2015 Plan"). The maximum number of shares that can be offered under this plan is 700,000. Incentives may be granted under the 2015 Plan to eligible participants in the form of (a) incentive stock options, (b) non-qualified stock options, (c) restricted shares, (d) restricted stock units, (e) share appreciation rights and (f) other share-based awards. Incentive grants under the 2015 Plan generally vest based on four years of continuous service and have 10-year contractual terms.

Stock-Based Compensation

Stock-based compensation expense is recognized, net of an estimated forfeiture rate, on a straight-line basis over the requisite service period, which is the vesting period.

The Company currently uses the Black-Scholes option pricing model to determine the fair value of its stock options and the Monte Carlo option pricing model to determine the fair value of its performance stock options. The determination of the fair value of stock-based payment awards on the date of grant using an option pricing model is affected by the Company's stock price, as well as assumptions regarding a number of complex and subjective variables. These variables include the Company's expected stock price volatility over the term of the awards, actual employee exercise behaviors, risk-free interest rate and expected dividends.

The weighted average fair value of stock options granted during the periods and the assumptions used to estimate those values using the Black-Scholes option pricing mode were as follows:

      Three Months Ended     Nine Months Ended
      September 30,     September 30,
      2016     2015     2016     2015
Weighted average expected                        
     stock price volatility     81.7%     71.4%     71.8%     72.3%
Estimated dividend yield     -       -       -       -  
Risk-free interest rate     1.3%     1.8%     1.4%     1.7%
Expected life of option (in years)     6.2      6.3      6.2      6.3 
Weighted average grant date                        
     fair value per option   $ 4.20    $ 30.90    $ 12.59    $ 42.60 

The expected stock price volatility for the stock options is based on historical volatility of the Company's stock. The Company has not paid and does not anticipate paying cash dividends; therefore, the expected dividend rate is assumed to be 0%. The risk-free rate was based on the U.S. Treasury yield curve in effect at the time of grant commensurate with the expected life assumption. The expected life of the stock options granted was estimated based on the historical exercise patterns over the option lives.  

Stock-based compensation expense was ($159,000) and $2.1 million for the three and nine months ended September 30, 2016, respectively and $1.3 million and $4.4 million for the three and nine months ended September 30, 2015, respectively. Stock-based compensation expense for the periods presented is included within the selling, general and administrative expense in the unaudited condensed consolidated statements of operations.

Stock Options

As of September 30, 2016, approximately 659,000 options are outstanding that have been issued to employees and directors under the Company's Golf Trust of America, Inc. 2007 Stock Option Plan, the Amended and Restated Pernix Therapeutics Holdings, Inc. 2009 Stock Incentive Plan and the 2015 Plan. As of September 30, 2016, there was approximately $7.9 million of total unrecognized compensation cost related to non-vested stock options issued to employees and directors of the Company, which is expected to be recognized ratably over a weighted-average period of 2.60 years.

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During the year ended December 31, 2015, the Company's Board of Directors awarded a total of 48,500 stock options ("Performance Options") to certain of the Company's executive officers. A determination of whether and how many of the Performance Options vest and become exercisable will be made on August 14, 2018 (the "Measuring Date") (the date that is three-years from the grant date) based upon the average closing bid price of the Company's Common Stock for the twenty trading days ending on the Measuring Date. If the average closing bid price of the Company's Common Stock for the twenty trading days immediately ending on the Measuring Date is (i) less than $200 per share, no Performance Options vest, (ii) $200 per share or more and less than $250 per share, then 50% of the Performance Options vest, (iii) $250 per share or more and less than $300 per share, then 75% of the Performance Options vest, (iii) $300 per share or more and less than $350 per share, then 100% of the Performance Options vest, and (iv) $350 per share or more, then 150% of the Performance Options vest. 50% of any such vested options shall be exercisable on the Measuring Date and the remaining 50% of such vested options shall be exercisable one year after the Measuring Date. Upon a change of control of the Company after the Measuring Date, any vested but exercisable Performance Options shall become exercisable. Upon a change of control prior to the Measuring Date, the Measuring Date shall become the effective date of the change of control and the amount of Performance Options that vest, if any, shall be based upon the common stock price as of the effective date of the change of control. For example, if a change of control occurs prior to August 14, 2018 and the price of the Company's Common Stock for the twenty trading days prior to the effective date of the change of control is $240 per share then each named executive officer would vest in 50% of the Performance Options.

The Company utilized a Monte Carlo Simulation to determine the grant date fair value of the Performance Options. Compensation expense is recognized over the performance period of each tranche in accordance with ASC 718,  Compensation - Stock Compensation . The Company recorded $0 and $35,000 for the three and nine months ended September 30, 2016, respectively and $15,000 for the three and nine months ended September 30, 2015 of share-based compensation expense related to these Performance Options. Due to the corporate restructuring that was announced in July 2016 and the associated departures of Company's former executive officers, all Performance Options have been canceled.

The following table shows the option activity, described above, during the nine months ended September 30, 2016 (share and intrinsic values in thousands):

                  Weighted Average      
            Average     Remaining     Aggregate
            Exercise     Contractual Life     Intrinsic
      Shares     Price     (years)     Value
Options Outstanding at December 31, 2015     703    $ 55.42             
     Granted     328      19.64             
     Exercised     -       -           $ -  
     Cancelled     (372)     49.19             
     Expired     -       -              
Options outstanding at September 30, 2016     659    $ 41.13      8.3    $ 37 
Options vested and expected to                         
     vest as of September 30, 2016     598    $ 41.99      8.3    $ 28 
Options vested and exercisable as of September 30, 2016     235    $ 50.87      7.4    $ -  

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Restricted Stock

The following table shows the Company's non-vested restricted stock activity during the nine months ended September 30, 2016 (share and intrinsic values in thousands):

                  Weighted Average     Aggregate
                  Grant Date Fair     Intrinsic
            Shares     Value     Value
Non-vested restricted stock outstanding at December 31, 2015             $ 30.00       
     Granted           -       -        
     Vested           (6)     30.00    $ 63 
     Forfeited           -       -        
Non-vested restricted stock outstanding at September 30, 2016           -     $ -        

As of September 30, 2016, there was $0 of total unrecognized compensation cost related to non-vested restricted stock issued to employees and directors of the Company due to the acceleration of restricted stock expense related to the restructuring during the year ended December 31, 2015.

Note 9. Income Taxes

The Company reported an income tax expense of $1,000 and $26,000 for the three and nine months ended September 30, 2016, respectively and a benefit of $5.6 million and $13.8 million for the three and nine months ended September 30, 2015, respectively. The Company's effective tax rate was 0.0% for the nine months ended September 30, 2016, compared to an estimated annual effective rate of 17.2% for the nine months ended September 30, 2015. The change in tax rate for the nine months ended September 30, 2016 was primarily due to the Company having a full valuation allowance as of and for the nine months ended September 30, 2016.

Deferred income taxes reflect the net tax effects of temporary differences between the carrying amount of the assets and liabilities for financial reporting purposes and the amounts used for income tax purposes. All deferred tax assets were subject to a full valuation allowance as of December 31, 2015.

The Company evaluates the realizability of its U.S. net deferred tax assets based on all available evidence, both positive and negative, on a quarterly basis. The realization of net deferred tax assets is dependent on the Company's ability to generate sufficient future taxable income during periods prior to the expiration of tax attributes to fully utilize these assets. The Company weighed both positive and negative evidence and determined that due to recent losses there is a continued need for a full valuation allowance against all of the Company's deferred tax assets as of September 30, 2016 and December 31, 2015.

Our gross deferred tax assets are comprised primarily of U.S. Federal net operating losses and accruals. A substantial portion of the deferred tax liability at September 30, 2016 relates to the difference between the financial statement and tax basis of the intangibles acquired in the Cypress acquisition. The deferred tax liability related to these Cypress intangibles is reduced on an annual basis by the financial statement amortization of such intangibles.

Income tax returns subject to review by taxing authorities include 2012, 2013, 2014 and 2015.

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Note 10. Commitments and Contingencies

Legal Proceedings

GlaxoSmithKline Arbitration

The Company is currently involved in an arbitration proceeding with GSK. GSK has claimed that the Company owes GSK damages relating to an alleged breach by the Company of a covenant contained in the Asset Purchase and Sale Agreement ("APSA") dated as of May 13, 2014 by and among GSK and its affiliates and the Company pertaining to a pre-existing customer agreement. The Company has asserted counterclaims and defenses under the APSA and also asserted claims against GSK related to breaches of a Supply Agreement between the parties. The Company and GSK entered into an Interim Settlement Agreement under which the Company agreed to make payments to GSK and escrow additional funds. Additionally, the parties agreed to submit the matter to binding arbitration. The Company has paid GSK approximately $10.3 million through September 30, 2016 and deposited an additional amount of approximately $6.2 million into an escrow account on account of the settlement of disputed amounts. The amounts paid by the Company to GSK and escrowed represent approximately 46% of the amounts GSK claims are owed to them as a result of the Company's alleged breach under the APSA. The amounts paid and escrowed by the Company for GSK claims are consistent with the amounts accrued by the Company for managed care rebates and fees during the three and nine months ended September 30, 2016 and 2015. An arbitration hearing for the APSA claims was held in April 2016 and a second hearing for the Supply Agreement claims was held in October 2016. A decision by the arbitrators is expected no later than February 2017.

Recro Gainesville LLC v. Actavis Laboratories FL, Inc., District of Delaware Case Nos. 14-1118, 15-413, and 15-1196; Recro Gainesville LLC v. Alvogen Malta Operations Ltd., District of Delaware Case No. 14-1364

Recro is the owner of U.S. Patent Nos. 6,228,398 ("the '398 Patent") and 6,902,742 ("the '742 Patent"), both of which expire on November 1, 2019, and U.S. Patent No. 9,132,096 ("the '096 Patent"), which expires on September 12, 2034. All three patents (collectively, "the Orange Book Patents") are listed in the United States Food and Drug Administration's ("FDA") Orange Book: Approved Drug Products with Therapeutic Equivalence Evaluations ("Orange Book") as covering Zohydro ER. Actavis and Alvogen each filed Abbreviated New Drug Applications ("ANDAs") with the FDA seeking approval of proposed generic versions of Zohydro ER in 10, 15, 20, 30, 40, and 50 mg dosage strengths. Those ANDAs and amendments thereto contained certifications asserting that the Orange Book Patents are invalid and not infringed. Pursuant to the Hatch-Waxman Act, Recro brought suit against Actavis on September 3, 2014 and May 21, 2015 for declaratory judgment of infringement of the '398 and '742 Patents, and on December 23, 2015 for declaratory judgment of infringement of the '096 Patent. In response, Actavis filed counterclaims seeking declaratory judgments of noninfringement and invalidity of all three Orange Book Patents. Pursuant to the Hatch-Waxman Act, Recro brought suit against Alvogen on November 3, 2014 for declaratory judgment of infringement of the '398 and '742 Patents. In response, Alvogen filed counterclaims seeking declaratory judgments of noninfringement and invalidity of those two patents. On September 13, 2016, Recro and Actavis jointly filed a stipulation of dismissal of all claims and counterclaims relating to the '398 Patent, and that stipulation was entered by the Court on September 14, 2016. On September 29, 2016, Recro and Alvogen jointly filed a stipulation of dismissal of all claims and counterclaims then pending, and that stipulation was entered by the Court on September 30, 2016, ending the case between Recro and Alvogen. Recro and Actavis participated in a bench trial in the United States District Court for the District of Delaware regarding the '742 and '096 Patents, which was completed on October 7, 2016. During the trial, Actavis declined to pursue its invalidity counterclaims as to both the '742 and '096 Patents. The parties' post-trial submissions regarding the remaining issues of infringement have been filed.

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Other Commitments and Contingencies

In July 2012 and January 2013, Somaxon settled two patent litigation claims with parties seeking to market generic equivalents of Silenor. As of September 30, 2016, remaining payment obligations of the Company owed under these settlement agreements are $1.3 million. The balance is payable in equal annual installments of $250,000 through 2019, and a payment of $500,000, payable in 2017. The current portion is recorded in other liabilities - current and the non-current portion is recorded in other liabilities - long-term on the Company's unaudited condensed consolidated balance sheets as of September 30, 2016.

During the first quarter of 2014, the Company settled all claims arising from certain actions by Cypress under the Texas Medicaid Fraud Prevention Act prior to its acquisition by the Company. As part of the settlement, the Company agreed to pay $12.0 million, payable in annual amounts of $2.0 million until the settlement is paid in full. As of September 30, 2016, the net present value of remaining payment obligations owed under this settlement agreement are $5.4 million. The current portion is recorded in other liabilities - current and the non-current portion is recorded in other liabilities - long-term on the Company's unaudited condensed consolidated balance sheet as of September 30, 2016.

In connection with the acquisition of Treximet, the Company is responsible for the payment of royalties to Pozen of 18% of Treximet net sales with quarterly minimum royalty amounts of $4.0 million for the calendar quarters commencing on January 1, 2015 and ending on March 31, 2018.

Note 11. Restructuring

On July 7, 2016, the Company announced a restructuring of its sales force and operations. The reorganization plan included (1) a reduction of 54 sales positions, primarily from the Company's Neurology sales team; (2) prioritization and reorganization of sales territories to reduce the inefficient time that sales representatives spent driving long distances between customers; (3) improvement of the Company's compensation plan to incentivize the field sales staff to increase the frequency of calls on the focused targets; and (4) consolidation of the Neurology and Pain sales forces under one sales management structure to eliminate redundancies. In addition, as part of this initiative, the Company reduced its administrative staff by 6 employees. The Company incurred $2.3 million during the three and nine months ended September 30, 2016 in severance and other related cash expenses. The charge during the nine months ended September 30, 2016 was comprised of $1.3 million in severance related cash expenses, and $1.0 million in other cash related expenses. Associated severance and other related payments are expected to be paid by December 31, 2017.

On March 16, 2015, the Company instituted an initiative to restructure operations and shut down its Charleston, South Carolina site. This step was done to consolidate operations within the Company's headquarters located in Morristown, New Jersey. The Company incurred $0 during the three and nine months ended September 30, 2016, and a reduction of $4,000 and a charge of $1.2 million for the three and nine months ended September 30, 2015, respectively, related to the restructuring. The charge during the nine months ended September 30, 2015 was comprised of $541,000 in severance related cash expenses, and $653,000 for the modification and accelerated vesting of options and awards under existing employee agreements. Associated severance payments were paid by May 31, 2016.

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A summary of accrued restructuring costs, included as a component of accounts payable and accrued expenses on the unaudited condensed consolidated balance sheets, is as follows (in thousands):

      December 31,                       September 30,
      2015     Charges     Cash     Non-cash     2016
2016 restructuring costs   $   $ 2,277    $ (1,443)   $   $ 834 
2015 restructuring costs     104          (104)        
     Totals   $ 104    $ 2,277    $ (1,547)   $   $ 834 
                               
      December 31,                       September 30,
      2014     Charges     Cash     Non-cash     2015
2015 restructuring costs   $   $ 1,193    $ (289)   $ (653)   $ 251 

Note 12. Business Combinations

Consideration paid by the Company for each business it purchased is allocated to the assets and liabilities acquired based upon their estimated fair values as of the date of each acquisition. The excess of the purchase price over the estimated fair values of the assets acquired and liabilities assumed is recorded as goodwill.

Zohydro ER Acquisition

On April 24, 2015, Pernix completed the acquisition of the pharmaceutical product line, Zohydro ER, including an abuse-deterrent pipeline and all related intellectual property, a favorable supplier contract and an associated liability payable, and a specified quantity of inventory associated therewith, from Zogenix, Inc. ("Zogenix"). There were no other tangible or intangible assets acquired and liabilities assumed related to the Zohydro ER product line from Zogenix. The total purchase price consisted of an upfront cash payment of $80.0 million including a deposit of $10.0 million in an escrow fund, stock consideration of $11.9 million issued in common stock of Pernix, $927,000 for a specified quantity of inventory, and regulatory and commercial milestones of up to $283.5 million including a $12.5 million milestone payment upon approval of a ZX007 abuse-deterrent extended-release hydrocodone tablet and up to $271.0 million in potential sales milestones if the Zohydro ER product line achieves certain agreed-upon net sales targets.

The Zohydro ER product line acquisition was accounted for as a business combination in accordance with ASC 805 Business Combinations ("ASC 805"). The Company finalized the purchase price allocation in the quarter ended June 30, 2016 and recorded the measurement period adjustments in accordance with ASU 2015-16. The results of operations of the acquired Zohydro ER product line, along with the estimated fair values of the net assets acquired, have been included in the Company's unaudited condensed consolidated financial statements since the Company acquired Zohydro ER on April 24, 2015.

Treximet Acquisition

On August 20, 2014, the Company, through a wholly owned subsidiary PIL, formerly known as Worrigan Limited, completed the acquisition of the U.S. intellectual property rights to the pharmaceutical product, Treximet, from GSK. There were no other tangible or intangible assets acquired or liabilities assumed related to Treximet intellectual property from GSK. The total purchase price consisted of an upfront cash payment of $250.0 million and $1.95 million paid to GSK upon receipt of an updated Written Request for pediatric exclusivity from the FDA.  The Company funded this acquisition with $220.0 million in debt, plus approximately $32.0 million from available cash.

The Treximet acquisition was accounted for as a business combination in accordance with ASC 805. The Company finalized the purchase price allocation in the quarter ended September 30, 2015 and recorded the measurement period adjustments in accordance with ASU 2015-16.

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Note 13. Supplemental Cash Flow Information

      Nine Months Ended
      September 30,
      2016     2015
Supplemental disclosures of Cash Flow Information:            
     Cash (received) paid for income taxes, net   $ (3,482)   $ 140 
     Cash paid for interest     27,294      27,736 
Supplemental disclosures of Non-cash Investing and Financing Activities:            
     Conversion of 8.00% Convertible Notes         60,172 
     Issuance of 168,209 shares to Zogenix for Zohydro ER acquisition         11,926 

Note 14. Recent Accounting Pronouncements

In August 2016, the Financial Accounting Standards Board ("FASB") issued ASU 2016-15, Statement of Cash Flows (Topic 230) ("ASU 2016-15") which provides updated guidance on eight classification issues related to the statement of cash flows: debt prepayments and extinguishment costs, settlement of zero-'coupon bonds, contingent consideration payments made after a business combination, proceeds from the settlement of insurance claims, proceeds from the settlement of corporate-owned life insurance policies, distributions received from equity method investees, beneficial interests in securitization transactions and separately identifiable cash flows and application of the predominance principle. ASU 2016-15 is effective for fiscal years beginning after December 15, 2017, and interim periods within those fiscal years. Early adoption is permitted, including adoption in an interim period. If an entity early adopts the amendments in an interim period, any adjustments should be reflected as of the beginning of the fiscal year that includes that interim period. An entity that elects early adoption must adopt all of the amendments in the same period. The Company is currently assessing the potential impact of adopting ASU 2016-15 on its financial statements and related disclosures.

In March 2016, the FASB issued ASU 2016-09, Improvements to Employee Share-Based Payment Accounting , ("ASU 2016-09"). ASU 2016-09 simplifies several aspects of the accounting for share-based payment transactions, including the income tax consequences, classification of awards as either equity or liabilities and classification on the statement of cash flows. This ASU is effective for fiscal years, and interim periods within those years, beginning after December 15, 2016. Early adoption is permitted. The Company is currently assessing the potential impact of adopting ASU 2016-09 on its financial statements and related disclosures.

In February 2016, the FASB issued ASU 2016-02, Leases ("ASU 2016-02"). ASU 2016-02 supersedes the lease guidance under FASB Accounting Standards Codification ("ASC") Topic 840, Leases , resulting in the creation of FASB ASC Topic 842, Leases . ASU 2016-02 requires a lessee to recognize in the statement of financial position a liability to make lease payments and a right-of-use asset representing its right to use the underlying asset for the lease term for both finance and operating leases. This ASU is effective for fiscal years, and interim periods within those years, beginning after December 15, 2018. Early adoption is permitted. The Company is currently assessing the potential impact of adopting ASU 2016-02 on its financial statements and related disclosures.

In January 2016, the FASB issued Accounting Standards Update ASU 2016-01, Financial Instruments-Overall (Subtopic 825-10): Recognition and Measurement of Financial Assets and Financial Liabilities ("ASU 2016-01"). The accounting standard primarily affects the accounting for equity investments, financial liabilities under the fair value option, and the presentation and disclosure requirements for financial instruments. In addition, it includes a clarification related to the valuation allowance assessment when recognizing deferred tax assets resulting from unrealized losses on available-for-sale debt securities. The accounting guidance is effective for annual reporting periods (including interim periods within those periods) beginning after December 15, 2017. Early adoption is permitted for the provision to record fair value changes for financial liabilities under the fair value option resulting from instrument-specific credit risk in other comprehensive income. The adoption of this standard is not expected to have a material impact on our financial position or results of operations.

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In July 2015, the FASB issued, ASU 2015-11, Inventory (Topic 330): Simplifying the Measurement of Inventory which requires that inventory within the scope of the guidance be measured at the lower of cost and net realizable value. Prior to the issuance of the standard, inventory was measured at the lower of cost or market (where market was defined as replacement cost, with a ceiling of net realizable value and floor of net realizable value less a normal profit margin). The accounting guidance is effective for annual reporting periods (including interim periods within those periods) beginning after December 15, 2016. Early adoption is permitted. The adoption of this standard is not expected to have a material impact on our financial position or results of operations.

In August 2014, the FASB issued ASU 2014-15, "Presentation of Financial Statements - Going Concern (Subtopic 205-40)." This ASU defines management's responsibility to evaluate whether there is substantial doubt about an organization's ability to continue as a going concern and provides guidance on required financial statement footnote disclosures. This ASU is effective for annual periods ending after December 15, 2016. The Company will adopt this ASU as of December 31, 2016 and use its guidance when evaluating whether there is substantial doubt about the Company's ability to continue as a going concern.

In May 2014, the FASB issued ASU 2014-09, Revenue from Contracts with Customers ("ASU 2014-09"). ASU 2014-09 supersedes the revenue recognition requirements of FASB ASC Topic 605, Revenue Recognition and most industry-specific guidance throughout the ASC, resulting in the creation of FASB ASC Topic 606, Revenue from Contracts with Customers . ASU 2014-09 requires entities to recognize revenue in a way that depicts the transfer of promised goods or services to customers in an amount that reflects the consideration to which the entity expects to be entitled to in exchange for those goods or services. This ASU provides alternative methods of adoption. In August 2015, the FASB issued ASU 2015-14, Revenue from Contracts with Customers, Deferral of the Effective Date ("ASU 2015-14"). ASU 2015-14 defers the effective date of ASU 2014-09 by one year to December 15, 2017 for fiscal years, and interim periods within those years, beginning after that date and permits early adoption of the standard, but not before the original effective date for fiscal years beginning after December 15, 2016. In March 2016, the FASB issued ASU 2016-08, Revenue from Contracts with Customers, Principal versus Agent Considerations (Reporting Revenue Gross versus Net) ("ASU 2016-08") clarifying the implementation guidance on principal versus agent considerations. Specifically, an entity is required to determine whether the nature of a promise is to provide the specified good or service itself (that is, the entity is a principal) or to arrange for the good or service to be provided to the customer by the other party (that is, the entity is an agent). The determination influences the timing and amount of revenue recognition. In April 2016, the FASB issued ASU 2016-10, Revenue from Contracts with Customers, Identifying Performance Obligations and Licensing , clarifying the implementation guidance on identifying performance obligations and licensing. Specifically, the amendments reduce the cost and complexity of identifying promised goods or services and improves the guidance for determining whether promises are separately identifiable. The amendments also provide implementation guidance on determining whether an entity's promise to grant a license provides a customer with either a right to use the entity's intellectual property (which is satisfied at a point in time) or a right to access the entity's intellectual property (which is satisfied over time). The effective date and transition requirements for ASU 2016-08 and ASU 2016-10 are the same as the effective date and transition requirements for ASU 2014-09. The Company is currently assessing the potential impact of adopting ASU 2014-09, ASU 2016-08 and ASU 2016-10 on its financial statements and related disclosures.

There were no other recent accounting pronouncements that have not yet been adopted by the Company that are expected to have a material impact on the Company's consolidated financial statements.

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ITEM 2. MANAGEMENT'S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION AND RESULTS OF OPERATIONS

The following discussion and analysis of our financial condition and results of operations should be read in conjunction with our unaudited condensed consolidated financial statements and the related notes included in "Part I-Item 1. Financial Statements" of this Quarterly Report on Form 10-Q and the condensed consolidated financial statements and notes thereto and Management's Discussion and Analysis of Financial Condition and Results of Operations contained in our Annual Report on Form 10-K for the year ended December 31, 2015. Some of the information contained in this discussion and analysis or set forth elsewhere in this Quarterly Report on Form 10-Q, including information with respect to our plans and strategy for our business and related financing, includes forward-looking statements that involve risks and uncertainties, including, but not limited to, those set forth under "Part I-Item1A. Risk Factors" of our Annual Report on Form 10-K for the year ended December 31, 2015 and "Part II-Item1A. Risk Factors" of this Quarterly Report on Form 10-Q for the three and nine months ended September 30, 2016.

The discussion below contains forward-looking statements within the meaning of Section 21E of the Securities Exchange Act of 1934, as amended, or the Exchange Act. For this purpose, any statements contained herein, other than statements of current or historical fact, including statements regarding our current expectations of our future growth, results of operations, financial condition, cash flows, performance and business prospects, and opportunities and any other statements about management's future expectations, beliefs, goals, plans or prospects, constitute forward-looking statements. We have tried to identify forward-looking statements by using words such as "anticipate," "believe," "could," "estimate," "expect," "intend," "may," "plan," "project," "should," "target," "will," "would" or other words that convey uncertainty of future events or outcomes to identify these forward-looking statements. Among the factors that could cause actual results to differ materially from those indicated in the forward-looking statements are risks and uncertainties inherent in our business including, without limitation: our ability to successfully complete a refinancing or restructuring of our existing debt, the rate and degree of market acceptance of, and our ability and our distribution and marketing partners' ability to obtain reimbursement for, any approved products; our ability to successfully execute our sales and marketing strategy, including to continue to successfully recruit and retain sales and marketing personnel in the U.S.; our ability to obtain additional financing; our ability to maintain regulatory approvals for our products; the accuracy of our estimates regarding expenses, future revenues and capital requirements; our ability to manage our anticipated future growth; the ability of our products to compete with generic products as well as new products that may be developed by our competitors; our ability and our distribution and marketing partners' ability to comply with regulatory requirements regarding the sales, marketing and manufacturing of our products; the performance of our manufacturers, over which we have limited control; our ability to obtain and maintain intellectual property protection for our products; our ability to operate our business without infringing the intellectual property rights of others; the success and timing of our clinical development efforts; the loss of key scientific or management personnel; regulatory developments in the U.S. and foreign countries; our ability to either acquire or develop and commercialize other product candidates in addition to our current products and other risks detailed above in "Part I-Item 1A. Risk Factors" of our Annual Report on Form 10-K for the year ended December 31, 2015 and "Part II-Item1A. Risk Factors" of this Quarterly Report on Form 10-Q for the three and nine months ended September 30, 2016.

Although we believe that the expectations reflected in our forward-looking statements are reasonable, we cannot guarantee future results, events, levels of activity, performance or achievement. In addition, any forward-looking statements in this Quarterly Report on Form 10-Q represent our views only as of the date of this Quarterly Report on Form 10-Q and should not be relied upon as representing our views as of any subsequent date. We anticipate that subsequent events and developments may cause our views to change. However, while we may elect to update these forward-looking statements publicly at some point in the future, we specifically disclaim any obligation to do so unless required by law, whether as a result of new information, future events or otherwise. Our forward-looking statements do not reflect the potential impact of any acquisitions, mergers, dispositions, business development transactions, joint ventures or investments we may enter into or make in the future. 

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Overview

We are a specialty pharmaceutical company focused on improving patients' lives by identifying, developing and commercializing differentiated products that address unmet medical needs. Our strategy is to continue to create shareholder value by:

  • Growing sales of the existing products in our portfolio in various ways, including identifying new growth opportunities;
  • Acquiring additional marketed specialty products or products close to regulatory approval to leverage our existing expertise and infrastructure; and
  • Pursuing targeted development of a pipeline of post-discovery specialty product candidates.

We target underserved segments, such as central nervous system (CNS) indications, including neurology, pain and psychiatry, as well as other specialty therapeutic areas. We promote our core branded products to physicians through our sales force. We promote our non-core branded products through co-promotion arrangements with established third-party sales organizations, and we market our generic products through our wholly owned subsidiaries, Macoven and Cypress.

Our branded products include Treximet, a medication indicated for the acute treatment of migraine attacks, with or without aura, in adults, Zohydro ER® with BeadTek, an extended-release opioid agonist indicated for the management of pain, Silenor, a non-controlled substance and approved medication indicated for the treatment of insomnia characterized by difficulty with sleep maintenance.

Product Update

Treximet

On August 11, 2016, we announced that we are discontinuing the development of a new formulation of Treximet that we had intended to launch prior to generic entry in early 2018. We recently experienced a delay related to the manufacturing of our proposed new formulation, and based on the revised development timeline, we do not believe the required spending on this program can achieve an acceptable return on investment. While we expect to realize near-term cost savings, we still believe that Treximet and our authorized generic will be important components of our product portfolio.

Zohydro ER with BeadTek

We inherited a development program for Zohydro ER with BeadTek as part of the acquisition of Zohydro ER in 2015. Several key studies designed to highlight some of the abuse-deterrent characteristics of Zohydro ER with BeadTek have been completed.

The first study was a Category 1 study to evaluate Zohydro ER with BeadTek for susceptibility to physical manipulation and chemical extraction of hydrocodone compared to the original formulation of Zohydro ER. The study demonstrated that injection by needles and syringes of various sizes is deterred in Zohydro ER with BeadTek, and that Zohydro ER with BeadTek deters abuse via common means such as crushing, grinding, and dissolving in commonly available and other aqueous and non-aqueous solvents. Further, all formulations studied were seen to decompose when heated, indicating abuse by inhalation of vapor will not be effective.

In a separate, Category 3 intranasal Human Abuse Liability study, we assessed the abuse potential of crushed Zohydro ER with BeadTek capsules administered intranasally to nondependent, recreational opioid users with intranasal experience. The primary objective of the study was to assess the abuse potential of crushed Zohydro ER with BeadTek compared to the original formulation of Zohydro ER, with secondary objectives comparing Zohydro ER with BeadTek and the original formulation to hydrocodone API and placebo. The study demonstrated a statistically significant reduction in Drug Liking for Zohydro ER with BeadTek compared to the original formulation, thus meeting the primary objective of the study. However, the difference in Drug Liking compared to hydrocodone API was not statistically significant and the secondary endpoints did not demonstrate statistical significance.

29


While these results support some of the abuse-deterrent properties of Zohydro ER with BeadTek, most notably the potential to deter intravenous abuse, we believe an opportunity exists to strengthen the properties of the product. As a result, we have prioritized the development of a next generation version of Zohydro ER with enhanced abuse-deterrent characteristics. The recent strengthening of our intellectual property portfolio for Zohydro ER through 2033 has allowed us to consider several options for our next generation product with enhanced abuse deterrent properties.

See Part I, Item 1 - Business included in our Annual Report on Form 10-K for the year ended December 31, 2015 for additional information regarding our products and product candidates.

Quarterly Update

  • On July 7, 2016, we announced a restructuring of our sales force and operations. The reorganization plan included (1) a reduction of 54 sales positions, primarily from our Neurology sales team; (2) prioritization and reorganization of sales territories to reduce the inefficient time that sales representatives spent driving long distances between customers; (3) improvement of our compensation plan to incentivize the field sales staff to increase the frequency of calls on the focused targets; and (4) consolidation of the Neurology and Pain sales forces under one sales management structure to eliminate redundancies. In addition, as part of this initiative, we reduced our administrative staff by 6 employees.
  • On July 26, 2016, we announced a reorganization of our senior management team intended to improve our efficiency, drive profitability and position the Company for future growth. As part of the management change, John Sedor assumed the role of Chief Executive Officer on a permanent basis and pharmaceutical industry veteran, Dr. Graham Miao, who previously served as a senior advisor to Pernix's Board of Directors since May, was appointed as President and Chief Financial Officer. Dr. Miao reports directly to Mr. Sedor and has responsibility for all functions related to finance, operations, regulatory and scientific affairs. In addition, Sanjay Patel, Chief Financial Officer, Terence Novak, Chief Operating Officer, and Barry Siegel, Senior Vice President and General Counsel are no longer employed by Pernix.
  • On August 11, 2016, we announced the commencement of a formal process to pursue alternatives to improve financial flexibility, and we have retained advisors to explore options to restructure our debt and assess other potential alternatives in order to maximize value for all stakeholders. We are currently negotiating with a group of note holders of the Treximet Secured Notes and a group of note holders of the 4.25% Convertible Notes. We are proposing an exchange of both the Treximet Secured Notes and the 4.25% Convertible Notes into a package of new securities, including debt securities, preferred equity securities, common stock and warrants to purchase common stock.
  • On October 13, 2016, we filed Articles of Amendment to our charter, with the State Department of Assessments and Taxation of Maryland to effect a one-for-ten reverse stock split of the outstanding shares of common stock, par value $0.01 per share. The purpose of the Reverse Stock Split was to raise the per share trading price of our common stock to regain compliance with the minimum $1.00 continued listing requirement for the listing of our common stock on The NASDAQ Global Market. As of the date of this Report, we have regained compliance with NASDAQ Listing Rule 5450(a)(1).
  • On November 1, 2016, we made the decision that we would not be exercising our option to obtain an exclusive, royalty-bearing license to the Altus Technology and the Altus Product Technology, as defined in the Development and Option Agreement dated November 1, 2013 between Zogenix, Inc. and Altus Formulation, Inc. The decision was made based on a careful evaluation of the Development and Option Agreement and the potential alternative technologies available to Pernix. We remain committed to continuing to improve the abuse-deterrent properties of Zohydro ER by investing in innovative technologies for future development of the product, including a reformulation of Zohydro ER with BeadTek and/or the license, development and commercialization of other abuse-deterrent technologies.

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  • On November 3, 2016, we entered into employment agreements with each of John A. Sedor, the Company's Chief Executive Officer and Dr. Miao, the Company's President and Chief Financial Officer.
  • On November 4, 2016, our Board of Directors increased its size to 5 members and appointed Graham Miao and Dennis Langer as members of the Board of the Directors. In addition, the Board of Directors appointed Dr. Langer to Compensation Committee as chairman and the Audit and Nominating Committees as a member. We are now in compliance with the "three independent member audit committee" requirement of The NASDAQ Stock Market Listing Rule 5605(c)(2)(A).

Controlled Equity Offering

On November 7, 2014, we entered into a controlled equity offering sales agreement (the "Sales Agreement") with Cantor Fitzgerald & Co. ("Cantor") pursuant to which we could issue and sell shares of our common stock having an aggregate offering price of up to $100,000,000 from time to time through Cantor, acting as agent. We will pay Cantor a commission rate of 3.0% of the gross sales price per share of the common stock sold through Cantor as agent under the Sales Agreement.

During the three months ended September 30, 2016, we sold 984,148 shares of common stock under the Sales Agreement, pursuant to an effective registration statement on Form S-3 (No. 333-200005), at an average price of approximately $6.56 per share, for gross proceeds of $6.5 million and net proceeds of $6.2 million, after deducting Cantor's commission. During the nine months ended September 30, 2016, we sold 3,376,284 shares of common stock under the Sales Agreement, pursuant to an effective registration statement on Form S-3 (No. 333-200005), at an average price of approximately $5.59 per share, for gross proceeds of $18.9 million and net proceeds of $18.3 million, after deducting Cantor's commission. As of September 30, 2016, approximately $81.1 million of common stock remained available to be sold under this facility.

Results of Operations

Comparison of Three Months Ended September 30, 2016 and 2015

The following table summarizes our results of operations for the three months ended September 30, 2016 and 2015 (in thousands):

      Three Months Ended            
      September 30,     Increase /      
      2016     2015     (Decrease)     Percent
Net revenues   $ 41,468    48,615    (7,147)     -15%
                         
Costs and operating expenses:                        
     Cost of product sales     10,840      12,036      (1,196)     -10%
     Selling, general and administrative expense     22,173      27,419      (5,246)     -19%
     Research and development expense     1,712      3,180      (1,468)     -46%
     Depreciation and amortization expense     20,700      25,733      (5,033)     -20%
     Change in fair value of contingent consideration     516      (3,596)     4,112      *
     Loss from disposal and impairments of assets     652          652      *
     Restructuring costs     2,277      (4)     2,281      *
Other income (expense):                        
     Interest income         43      (43)     *
     Interest expense     (8,857)     (9,687)     (830)     -9%
     Change in fair value of derivative liability     (209)     10,527      (10,736)     *
     Foreign currency transaction gain     31          31      *
     Loss on extinguishment of debt         (1,112)     (1,112)     *
Income tax expense (benefit)         (5,642)     (5,643)     *

 

*   Comparison to prior period is not meaningful.

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Net Revenues

Net revenues consist of net product sales and revenue from co-promotion and other revenue sharing arrangements. We recognize product sales net of estimated allowances for product returns, price adjustments (customer rebates, managed care rebates, service fees, chargebacks, coupons and other discounts), government program rebates (Medicaid, Medicare and other government sponsored programs) and prompt pay discounts. The primary factors that determine our net product sales are the level of demand for our products, unit sales prices, the applicable federal and supplemental government program rebates, contracted rebates, services fees, and chargebacks and other discounts that we may offer such as consumer coupon programs. In addition to our own product portfolio, we have entered into co-promotion agreements and other revenue sharing arrangements with various parties in return for a percentage of revenue on sales we generate or on sales they generate.

The following table sets forth a summary of our net revenues for the three months ended September 30, 2016 and 2015 (in thousands):

      Three Months Ended            
      September 30,     Increase /      
      2016     2015     (Decrease)     Percent
Treximet   $ 24,015    $ 28,571    $ (4,556)     -16%
Silenor     4,615      5,149      (534)     -10%
Zohydro ER     6,100      5,363      737      14%
Other     6,667      8,546      (1,879)     -22%
     Net product sales     41,397      47,629      (6,232)     -13%
Co-promotion and other revenue     71      986      (915)     -93%
Total net revenues   $ 41,468    $ 48,615    $ (7,147)     -15%

Net revenues decreased $7.1 million or 15% during the three months ended September 30, 2016 compared to the three months ended September 30, 2015.

Treximet net sales decreased by $4.6 million or 16% during the three months ended September 30, 2016 compared to the three months ended September 30, 2015 due primarily to $3.9 million of inventory changes at the wholesaler level and a decrease in the net selling price of Treximet and other factors.

Silenor net sales decreased by $534,000, or 10%, during the three months ended September 30, 2016 compared to the three months ended September 30, 2015. The decrease in net sales of Silenor was primarily driven by a lower net selling price.

Zohydro ER was acquired in April 2015 with the first sale occurring on May 4, 2015. Zohydro ER net sales increased by $737,000 or 14% during the three months ended September 30, 2016 compared to the three months ended September 30, 2015. The increase was primarily due to a $705,000 increase in demand, a $809,000 increase in the net selling price, which were partially offset by a $776,000 decrease due to inventory changes at the wholesaler level.

Net product sales - other decreased by $1.9 million, or 22%, during the three months ended September 30, 2016 compared to the three months ended September 30, 2015. Declining net product sales - other was due to (i) the discontinuation of certain less profitable products, primarily generics, and certain OTC monograph seasonal cough and cold products and (ii) the termination of certain contracts pursuant to which we marketed and distributed products for others and invoiced those sales.

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Co-promotion and other revenue decreased by $915,000 during the three months ended September 30, 2016 compared to the three months ended September 30, 2015. The decrease in co-promotion and other revenue was primarily attributable to the termination of the co-promotion agreement on Omeclamox.

Cost of Product Sales

Cost of product sales decreased by $1.2 million, or 10%, during the three months ended September 30, 2016, compared to the three months ended September 30, 2015. The decrease in cost of product sales is primarily due to lower royalty expenses based on decreased net sales.

Selling, General and Administrative Expense

Selling, general and administrative expense decreased by $5.2 million, or 19%, during the three months ended September 30, 2016 compared to the three months ended September 30, 2015.  The decrease was driven primarily by lower selling and marketing costs for Treximet and Silenor, partially offset by higher legal expenses.

Research and Development Expense

Research and development expense decreased by $1.5 million during the three months ended September 30, 2016 compared to the three months ended September 30, 2015. The decrease was related to the timing of work for Zohydro ER.

Depreciation and Amortization Expense

Depreciation and amortization expense decreased by $5.0 million during the three months ended September 30, 2016 compared to the three months ended September 30, 2015. The decrease was primarily a result of an extension of the estimated useful life of Zohydro ER with BeadTek during the three months ended March 31, 2016 due to the additional patents that were issued in February 2016 and intangible asset impairments during the nine months ended September 30, 2016 and the fourth quarter of 2015.

Change in Fair Value of Contingent Consideration

For the acquisition of Zohydro ER, we recorded $14.2 million of contingent consideration. The fair value of the contingent consideration linked to FDA approval was $2.7 million and the fair value of the contingent consideration linked to achievement of the net sales target was $11.5 million. As of September 30, 2016, the current fair value of the contingent consideration is approximately $5.1 million. We recorded an expense of $516,000 and a benefit of $3.6 million as change in fair value of contingent consideration in the three months ended September 30, 2016 and 2015, respectively.

Restructuring Costs

Restructuring costs were $2.3 million and a credit of $4,000 during the three months ended September 30, 2016 and 2015, respectively. Restructuring costs during the three months ended September 30, 2016 were related to the initiative to restructure our sales force and operations as discussed above.

Interest Expense

Interest expense decreased by $830,000, or 9%, during the three months ended September 30, 2016 compared to the three months ended September 30, 2015. The decrease was primarily due to the lower principal balance on the Treximet Secured Notes which reduced interest expense by $657,000 during the three months ended September 30, 2016.

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Change in Fair Value of Derivative Liability

We are required to separate the conversion option in the 4.25% Convertible Notes under ASC 815, Derivatives and Hedging . We recorded the bifurcated conversion option valued at $28.5 million at issuance, as a derivative liability, which creates additional discount on the debt. The derivative liability is marked to market through the other income (expense) section on the unaudited condensed consolidated statements of operations for each reporting period. We recorded an expense of $209,000 and a benefit of $10.5 million as change in fair value of derivative liability in other income (expense) in the three months ended September 30, 2016 and 2015, respectively.

Loss on extinguishment of debt

During the three months ended September 30, 2015, we terminated the MidCap Credit Facility and recorded a $1.1 million loss on extinguishment of debt for the deferred financing costs that had been capitalized at the time of acquisition of this debt in other expense, net.

Income Tax Expense (Benefit)

We recognized an income tax expense of $1,000 and a benefit of $5.6 million, during the three months ended September 30, 2016 and 2015, respectively. The change in tax rate for the three months ended September 30, 2016 was primarily related to a change in our judgment that, based on the evaluation of all available evidence, our deferred tax assets are not more likely than not realizable, which resulted in a valuation allowance recorded against our deferred tax assets.

Comparison of Nine Months Ended September 30, 2016 and 2015

The following table summarizes our results of operations for the nine months ended September 30, 2016 and 2015 (in thousands):

      Nine Months Ended            
      September 30,     Increase /      
      2016     2015     (Decrease)     Percent
Net revenues   $ 110,683    129,481    (18,798)     -15%
                         
Costs and operating expenses:                        
     Cost of product sales     34,272      36,906      (2,634)     -7%
     Selling, general and administrative expense     73,615      73,262      353      *
     Research and development expense     5,139      5,644      (505)     -9%
     Depreciation and amortization expense     65,426      66,492      (1,066)     -2%
     Change in fair value of contingent consideration     (8,958)     (3,596)     (5,362)     *
     Loss from disposal and impairments of assets     2,423          2,423      *
     Restructuring costs     2,277      1,193      1,084      91%
Other income (expense):                        
     Interest income         153      (153)     *
     Interest expense     (26,818)     (28,818)     (2,000)     -7%
     Change in fair value of derivative liability     6,744      19,230      (12,486)     -65%
     Foreign currency transaction gain     98          98      *
     Loss on extinguishment of debt         (1,112)     (1,112)     *
     Cost of inducement         (19,500)     (19,500)     *
Income tax expense (benefit)     26      (13,818)     (13,844)     *

 

*   Comparison to prior period is not meaningful.

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Net Revenues

The following table sets forth a summary of our net revenues for the nine months ended September 30, 2016 and 2015 (in thousands):

      Nine Months Ended            
      September 30,     Increase /      
      2016     2015     (Decrease)     Percent
Treximet   $ 58,149    $ 74,997    $ (16,848)     -22%
Silenor     12,388      16,177      (3,789)     -23%
Zohydro ER     17,448      9,329      8,119      87%
Other     22,396      27,462      (5,066)     -18%
     Net product sales     110,381      127,965      (17,584)     -14%
Co-promotion and other revenue     302      1,516      (1,214)     -80%
Total net revenues   $ 110,683    $ 129,481    $ (18,798)     -15%

Net revenues decreased $18.8 million or 15% during the nine months ended September 30, 2016 compared to the nine months ended September 30, 2015.

Treximet net sales decreased by $16.8 million or 22% during the nine months ended September 30, 2016 compared to the nine months ended September 30, 2015 due to $8.3 million of inventory changes at the wholesaler level and $4.3 million decrease in demand and a $4.2 million decrease in the net selling price.

Silenor net sales decreased by $3.8 million, or 23%, during the nine months ended September 30, 2016 compared to the nine months ended September 30, 2015. The decrease in sales of Silenor was primarily driven by a $2.5 million decrease in the net selling price and $1.8 million of inventory changes at the wholesaler level. These decreases were partially offset by a $473,000 increase in demand.

Zohydro ER was acquired in April 2015 with the first sale occurring on May 4, 2015. Zohydro ER net sales increased by $8.1 million during the nine months ended September 30, 2016 compared to the prior period which consisted of five months of sales.

Net product sales - other decreased by $5.1 million, or 18%, during the nine months ended September 30, 2016 compared to the nine months ended September 30, 2015. Declining net product sales - other was due to (i) the discontinuation of certain less profitable products, primarily generics, and certain OTC monograph seasonal cough and cold products and (ii) the termination of certain contracts pursuant to which we marketed and distributed products for others and invoiced those sales.

Co-promotion and other revenue decreased by $1.2 million during the nine months ended September 30, 2016 compared to the nine months ended September 30, 2015. The decrease in co-promotion and other revenue was primarily attributable to the termination of the co-promotion agreement on Omeclamox.

Cost of Product Sales

Cost of product sales decreased by $2.6 million, or 7%, during the nine months ended September 30, 2016, compared to the nine months ended September 30, 2015. The decrease in cost of product sales is primarily due to lower royalty expenses based on decreased net sales.

35


Selling, General and Administrative Expense

Selling, general and administrative expense increased by $353,000 during the nine months ended September 30, 2016 compared to the nine months ended September 30, 2015.  The increase was driven primarily by selling and marketing costs for Zohydro ER with BeadTek, which was acquired in April 2015 and we began to promote in May 2015.

Research and Development Expense

Research and development expense decreased by $505,000 during the nine months ended September 30, 2016 compared to the nine months ended September 30, 2015. The decrease was related to the timing of work for Zohydro ER.

Depreciation and Amortization Expense

Depreciation and amortization expense decreased by $1.1 million during the nine months ended September 30, 2016 compared to the nine months ended September 30, 2015. The decrease was primarily related to intangible asset impairments during the nine months ended September 30, 2016 and the fourth quarter of 2015. These decreases were partially offset by the amortization of Treximet pediatrics developed technology which began in May 2015.

Change in Fair Value of Contingent Consideration

For the acquisition of Zohydro ER, we recorded $14.2 million of contingent consideration. The fair value of the contingent consideration linked to FDA approval was $2.7 million and the fair value of the contingent consideration linked to achievement of the net sales target was $11.5 million. As of September 30, 2016, the current fair value of the contingent consideration is approximately $5.1 million. We recorded a benefit of $9.0 million and $3.6 million as change in fair value of contingent consideration in the nine months ended September 30, 2016 and 2015, respectively.

Restructuring Costs

Restructuring costs were $2.3 million and $1.2 million during the nine months ended September 30, 2016 and 2015, respectively. Restructuring costs during the nine months ended September 30, 2016 were related to the initiative to restructure our sales force and operations as discussed above. Restructuring costs during the nine months ended September 30, 2015 were related to the initiative to restructure operations and shut down the Charleston, South Carolina site in 2015.

Interest Expense

Interest expense decreased by $2.0 million, or 7%, during the nine months ended September 30, 2016 compared to the nine months ended September 30, 2015. The decrease was primarily due to the lower principal balance on the Treximet Secured Notes.

Change in Fair Value of Derivative Liability

We are required to separate the conversion option in the 4.25% Convertible Notes under ASC 815, Derivatives and Hedging . We recorded the bifurcated conversion option valued at $28.5 million at issuance, as a derivative liability, which creates additional discount on the debt. The derivative liability is marked to market through the other income (expense) section on the unaudited condensed consolidated statements of operations for each reporting period. We recorded benefits of $6.7 million and $19.2 million as change in fair value of derivative liability in other income (expense) in the nine months ended September 30, 2016 and 2015, respectively.

36


Loss on extinguishment of debt

During the nine months ended September 30, 2015, we terminated the MidCap Credit Facility and recorded a $1.1 million loss on extinguishment of debt for the deferred financing costs that had been capitalized at the time of acquisition of this debt in other expense, net.

Cost of Inducement

In April 2015, we entered into the "Inducement Agreement" with all of the holders of our 8.00% Convertible Notes, pursuant to which such holders agreed to the removal of substantially all of the material restrictive covenants in the indenture governing such notes and to convert such notes in accordance with the provisions of such indenture in exchange for an aggregate of 233,813 shares of our common stock. The Company recorded $19.5 million as cost of inducement expense in the nine months ended September 30, 2015. For further discussion, see Note 7, Debt , to our unaudited condensed consolidated financial statements included in this Quarterly Report on Form 10-Q.

Income Tax (Benefit) Expense

During the nine months ended September 30, 2016, we recognized an income tax expense of $26,000. During the nine months ended September 30, 2015, we recognized an income tax benefit of $13.8 million. The change in tax rate for the nine months ended September 30, 2016 was primarily related to a change in our judgment that, based on the evaluation of all available evidence, our deferred tax assets are not more likely than not realizable, which resulted in a valuation allowance recorded against our deferred tax assets.

Non-GAAP Financial Measures

To supplement our financial results determined by GAAP, we have also disclosed in the tables below the following non-GAAP information: (a) adjusted earnings before interest, taxes, depreciation and amortization ("EBITDA") and (b) adjusted EBITDA per basic and diluted common share. This financial measure excludes the impact of certain items and, therefore, has not been calculated in accordance with GAAP. These non-GAAP financial measures exclude, among other things, depreciation and amortization, net interest, taxes, net revenue adjustments, deal expenses, share-based compensation expense, amortization of inventory step-up included in cost of product sales, severance expenses and restructuring costs (comprehensively "Adjustment Items"). In addition, from time to time in the future there may be other items that we may exclude for the purposes of our non-GAAP financial measures; likewise, we may in the future cease to exclude items that we have historically excluded for the purpose of our non-GAAP financial measures. We believe that these non-GAAP financial measures provide meaningful supplemental information regarding our operating results because they exclude amounts that management and the board of directors do not consider part of core operating results or that are non-recurring when assessing the performance of the organization. We believe that inclusion of these non-GAAP financial measures provides consistency and comparability with past reports of financial results and provides consistency in calculations by outside analysts reviewing our results. Accordingly, we believe these non-GAAP financial measures are useful to investors in allowing for greater transparency of supplemental information used by management.

We believe that non-GAAP financial measures are helpful in understanding our past financial performance and potential future results, but there are limitations associated with the use of these non-GAAP financial measures. These non-GAAP financial measures are not prepared in accordance with GAAP, do not reflect a comprehensive system of accounting and may not be completely comparable to similarly titled measures of other companies due to potential differences in the exact method of calculation between companies. Adjustment items that are excluded from our non-GAAP financial measures can have a material impact on net earnings. As a result, these non-GAAP financial measures have limitations and should not be considered in isolation from, or as a substitute for, net loss, cash flow from operations or other measures of performance prepared in accordance with GAAP. We compensate for these limitations by using these non-GAAP financial measures as supplements to GAAP financial measures and by reconciling the non-GAAP financial measures to their most comparable GAAP financial measure. Investors are encouraged to review the reconciliations of the non-GAAP financial measures to their most comparable GAAP financial measures that are included elsewhere in this Quarterly Report on Form 10-Q.

37


Reconciliation of GAAP reported net loss to adjusted EBITDA are as follows (in thousands):

      Three Months Ended     Nine Months Ended
      September 30,     September 30,
      2016     2015     2016     2015
GAAP net loss   $ (26,438)   $ (10,740)   $ (83,513)   $ (66,649)
Adjustments:                        
     Interest expense, net     8,857      9,644      26,818      28,665 
     Depreciation and amortization     20,730      25,733      65,475      66,492 
     Income tax expense (benefit)         (5,642)     26      (13,818)
EBITDA     3,150      18,995      8,806      14,690 
     Net revenue adjustments (1)         644          (2,339)
     Cost of product sales adjustments (2)                 97 
     Selling, general and administrative adjustments (3)     1,606      1,548      4,766      9,282 
     Research and development adjustments         500          500 
     Change in fair value of contingent consideration     516      (3,596)     (8,958)     (3,596)
     Loss from disposal and impairments of assets (4)     652          2,423     
     Loss on extinguishment of debt         1,112          1,112 
     Cost of inducement                 19,500 
     Change in fair value of derivative liability     209      (10,527)     (6,744)     (19,230)
     Foreign currency transaction gain     (31)         (98)    
     Restructuring costs (5)     2,277      (4)     2,277      1,193 
Adjusted EBITDA   $ 8,379    $ 8,672    $ 2,472    $ 21,209 

 

(1)

To include impact of change in estimates related to gross to net accruals of $0 and $644,000 for the three months ended September 30, 2016 and 2015, respectively. Also, to include impact of change in estimates related to gross to net accruals of $0 and $2.6 million and to exclude impact on returns from FDA reclass of Hydrocodone products from C3 to C2 classification of $0 and $303,000 for the nine months ended September 30, 2016 and 2015, respectively.

(2)

To exclude amortization of inventory step-up from acquisitions.

(3)

To exclude deal costs of $0 and $186,000; stock compensation expense of $(159,000) and $1.3 million; severance expense of $431,000 and $0; loss on disposal of assets of $0 and $19,000; and litigation settlement expenses of $1.3 million and $0 for the three months ended September 30, 2016 and 2015, respectively. Also, to exclude deal costs of $18,000 and $4.1 million; stock compensation expense of $2.1 million and $3.8 million; severance expense of $1.6 million and $0; litigation settlement expenses of $1.0 million and $1.4 million and loss on disposal of assets of $0 and $19,000 for the nine months ended September 30, 2016 and 2015, respectively.

(4)

To exclude the impairment of assets primarily related to our cough and cold product line.

(5)

To exclude the cost related to the initiative to restructure our sales force and operations in 2016 and the restructure of our operations and shut down of the Charleston, South Carolina site in 2015.

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Liquidity and Capital Resources

As of September 30, 2016, we had cash and cash equivalents of $28.5 million, borrowing availability of $11.4 million under our $50.0 million credit agreement, which may be increased by an additional $20.0 million in the lenders' discretion. Our debt included $189.6 million aggregate principal amount of our 12.0% Treximet Secured Notes issued August 19, 2014 and due August 1, 2020 ("Treximet Secured Notes"), $14.0 million under our senior secured revolving credit facility (the "Wells Fargo Credit Facility") and $130.0 million aggregate principal amount of our 4.25% Convertible Notes, issued April 22, 2015 and due April 1, 2021, ("4.25% Convertible Notes") unless earlier converted.

We have an effective shelf registration statement on Form S-3, which covers the offering, issuance and sale of up to $300.0 million of our common stock, preferred stock, debt securities, warrants, subscription rights and units.  The shelf registration statement includes a sales agreement prospectus covering the offering, issuance and sale of up to one hundred million dollars' worth of shares of our common stock that may be issued and sold under the Controlled Equity Offering Sales Agreement, dated November 7, 2014, between us and Cantor Fitzgerald & Co. as agent. We have sold 984,148 and 3,376,284 shares of common stock under this controlled equity program for net proceeds of $6.2 million and $18.3 million during the three and nine months ended September 30, 2016. This program will provide us with financial flexibility and the ability to opportunistically access the capital markets.

Our future capital requirements will depend on many factors, including:

  • the level of product sales of our currently marketed products and any additional products that we may market in the future;
  • the extent to which we acquire or invest in products, businesses and technologies;
  • the level of inventory purchase commitments under supply, manufacturing, license and/or co-promotion agreements;
  • the scope, progress, results and costs of development activities for our current product candidates;
  • the costs, timing and outcome of regulatory review of our product candidates;
  • the number of, and development requirements for, additional product candidates that we pursue;
  • the costs of commercialization activities, including product marketing, sales and distribution;
  • the costs and timing of establishing manufacturing and supply arrangements for clinical and commercial supplies of our product candidates and products;
  • the extent to which we choose to establish collaboration, co-promotion, distribution or other similar arrangements for our marketed products and product candidates;
  • the costs of and any judgments resulting from legal proceedings; and
  • the costs of preparing, filing and prosecuting patent applications and maintaining, enforcing and defending claims related to intellectual property owned by or licensed to us.

On each Payment Date, which commenced on August 1, 2015, the Company will pay an installment of principal on the Treximet Secured Notes in an amount equal to 50% of net sales of Treximet for the two consecutive fiscal quarters immediately preceding such Payment Date (less the amount of interest paid on the Treximet Secured Notes on such Payment Date). At each month-end beginning with January 2015, the net sales of Treximet will be calculated, and the monthly interest accrual amount will then be deducted from the net sales and this resulting amount will be recorded as the current portion of the Treximet Secured Notes. If the Treximet net sales less the interest due at each month-end of each six-month period does not result in any excess over the interest due, no principal payment will be paid at that time. The balance outstanding on the Treximet Secured Notes will be due on the maturity date of the Treximet Secured Notes, which is August 1, 2020.  Based on the calculation of the principal payments as described, the Company has recorded $189.0 million of Treximet Secured Notes as long-term debt and $633,000 as short-term debt as of September 30, 2016.

As of September 30, 2016, we believe that our existing cash balance, our ability to opportunistically access the capital markets and funds remaining available under our Wells Fargo Credit Facility, which may be increased by an additional $20.0 million in the lenders' discretion will be sufficient to fund our operations through the next year.

39


To continue to grow our business over the longer term, we may need to commit additional resources to one or more of the following: product acquisition, product development and clinical trials of product candidates, business acquisition, technology acquisition and expansion of other operations. In this regard, we have evaluated and expect to continue to evaluate a wide array of strategic transactions as part of our strategy to acquire or in-license and develop additional products and product candidates. To improve financial flexibility, we have retained advisors to explore options to restructure our debt and assess other potential alternatives in order to maximize value for all stakeholders. Acquisition opportunities that we pursue could materially affect our liquidity and capital resources and may require us to incur additional indebtedness, seek equity capital or both. In addition, we may pursue new operations or the expansion of our existing operations. There can be no assurance that the exploration of options will result in the identification or consummation of any transaction.

On July 7, 2016, we announced a restructuring of our sales force and operations. The reorganization plan included (1) a reduction of 54 sales positions, primarily from our Neurology sales team; (2) prioritization and reorganization of sales territories to reduce the inefficient time that sales representatives spent driving long distances between customers; (3) improvement of our compensation plan to incentivize the field sales staff to increase the frequency of calls on the focused targets; and (4) consolidation of the Neurology and Pain sales forces under one sales management structure to eliminate redundancies. In addition, as part of this initiative, we reduced our administrative staff by 6 employees. We anticipate that this reorganization will result in an estimated annualized cost savings of approximately $10 million, which began during the third quarter of 2016. We recorded a one-time charge of $2.3 million during the three and nine months ended September 30, 2016 in connection with this reorganization.

Cash Flows

The following table provides information regarding our cash flows for the nine months ended September 30, 2016, and 2015 (in thousands).

      Nine Months Ended
      September 30,
Cash (used in) provided by     2016     2015
Operating activities   $ (22,890)   $ (10,895)
Investing activities     (1,547)     (82,356)
Financing activities     (3,177)     115,583 
Net (decrease) increase in cash and cash equivalents   $ (27,614)   $ 22,332 

Comparison of the Nine Months Ended September 30, 2016 and 2015

Net cash used in operating activities

Net cash used in operating activities during the nine months ended September 30, 2016 was $22.9 million, an increase of $12.0 million from cash used in operating activities during the nine months ended September 30, 2015 of $10.9 million. The cash used in operating activities during the nine months ended September 30, 2016 was driven by the net loss of $83.5 million. This use was partially offset by non-cash expenses totaling $58.8 million and net changes in operating assets/liabilities of $1.8 million. The $10.9 million used in operating activities during the nine months ended September 30, 2015 was primarily driven by a net loss of $66.6 million, net changes in operating assets/liabilities of $5.0 million partially offset by non-cash expenses totaling $60.7 million.

Net cash used in investing activities

Net cash used in investing activities during the nine months ended September 30, 2016 was $1.5 million, which primarily consisted of purchases of fixed assets. The cash used of $82.4 million during the nine months ended September 30, 2015 was primarily due to the purchase of Zohydro ER with BeadTek.

40


Net cash (used in) provided by financing activities

Net cash used in financing activities during the nine months ended September 30, 2016 was $3.2 million. Cash used in financing activities for the nine months ended September 30, 2016 was primarily for principal payments on our Treximet Secured Notes of $20.4 million. This use was partially offset by the issuance of 3.4 million shares under the Controlled Equity Offering Sales Agreement for $18.3 million. Net cash provided by financing activities was $115.6 million for the nine months ended September 30, 2015 and was primarily due to the net proceeds of the issuance of the 4.25% Convertible Notes in April 2015 which were partially offset by a $10.0 million principal payment on our Treximet Secured Notes.

We have committed to make potential future milestone payments to third parties as part of licensing, distribution, acquisition and development agreements. Payments under these agreements generally become due and payable only upon achievement of certain development, regulatory and/or commercial milestones. As the achievement of milestones is neither probable nor reasonably estimable, such contingent payments have not been recorded, except for the contingent consideration discussed in Note 12, Business Combinations , for the acquisition of Zohydro ER in April 2015, on our unaudited condensed consolidated balance sheets.

ITEM 3. QUANTITATIVE AND QUALITATIVE DISCLOSURES ABOUT MARKET RISK

Not applicable.

ITEM 4. CONTROLS AND PROCEDURES

We maintain "disclosure controls and procedures" within the meaning of Rule 13a-15(e) of the Securities Exchange Act of 1934, as amended, or the Exchange Act. Our disclosure controls and procedures, or Disclosure Controls, are designed to ensure that information required to be disclosed by us in the reports we file under the Exchange Act, such as this Quarterly Report on Form 10-Q, is recorded, processed, summarized and reported within the time periods specified in the U.S. Securities and Exchange Commission's rules and forms. Our Disclosure Controls are also designed to ensure that such information is accumulated and communicated to our management, including our Chief Executive Officer and Chief Financial Officer, as appropriate, to allow timely decisions regarding required disclosure. In designing and evaluating our Disclosure Controls, management recognized that any controls and procedures, no matter how well designed and operated, can provide only reasonable assurance of achieving the desired control objectives, and management necessarily was required to apply its judgment in evaluating and implementing possible controls and procedures.

Evaluation of Disclosure Controls and Procedures.  As of September 30, 2016, we evaluated the effectiveness of the design and operation of the Company's disclosure controls and procedures, which was done under the supervision and with the participation of our management, including our Chief Executive Officer and our Chief Financial Officer. Immediately following the Signatures section of the Quarterly Report on Form 10-Q are certifications of our Chief Executive Officer and Chief Financial Officer, which are required in accordance with Rule 13a-14 of the Exchange Act. This Controls and Procedures section includes the information concerning the controls evaluation referred to in the certifications and it should be read in conjunction with the certifications for a more complete understanding of the topics presented. Based on the controls evaluation, our Chief Executive Officer and Chief Financial Officer concluded that as of the date of their evaluation, our disclosure controls and procedures were effective to provide reasonable assurance that (a) the information required to be disclosed by us in the reports that we file or submit under the Exchange Act is recorded, processed, summarized and reported within the time periods specified in the SEC's rules and forms, and (b) such information is accumulated and communicated to our management, including our Chief Executive Officer and President and Chief Financial Officer, as appropriate, to allow timely decisions regarding required disclosure.

Change in Internal Control over Financial Reporting . There were no changes in our internal control over financial reporting (as defined in Rule 13a-15(f) and Rule 15d-15(f) under the Exchange Act) during our most recent fiscal quarter that have materially affected, or are reasonably likely to materially affect, our internal control over financial reporting.

41


PART II. OTHER INFORMATION

ITEM 1. LEGAL PROCEEDINGS

Information regarding legal proceedings is incorporated by reference herein from Legal Proceedings under Note 10, Commitments and Contingencies , to our unaudited condensed consolidated financial statements for the three and nine months ended September 30, 2016 and 2015 contained in Part I, Item 1 of this Quarterly Report on Form 10-Q.

ITEM 1A. RISK FACTORS

Except for the additional disclosures set forth below, for additional information about our risk factors, see Part I, Item 1A of our Annual Report on Form 10-K for the year ended December 31, 2015, filed with the SEC on March 10, 2016.

Our board of directors has authorized us to explore alternatives to refinance or restructure our existing debt, which could materially and adversely affect our business. Any refinancing or restructuring of our existing debt will be highly dilutive to our existing equity holders and certain debt holders and could adversely affect the price of our common stock.

On August 11, 2016, we announced the commencement of a formal process to pursue alternatives to refinance or restructure our existing debt, including the engagement of external financial advisors. These alternatives may include, but not be limited to, seeking a restructuring or refinancing of our existing debt through a private restructuring or reorganization under Chapter 11 of the Bankruptcy Code. We believe the consummation of a successful refinancing or restructuring of our existing debt is critical to our continued viability. In connection with our exploration of alternatives to refinance or restructure our existing debt, we expect to incur expenses associated with identifying and evaluating our alternatives. The process of exploring refinancing or restructuring alternatives may be disruptive to our business operations. The inability to effectively manage the process and any resulting agreement or transaction could materially and adversely affect our business, financial condition or results of operations. Any refinancing or restructuring will likely be subject to a number of conditions, many of which will be outside of our control. We can make no assurances that any refinancing or restructuring that we pursue will be successful, or what the terms thereof would be or what, if anything, our existing debt and equity holders would receive in any resulting transaction, which will depend on our enterprise value, although we believe that any refinancing or restructuring would be highly dilutive to our existing equity holders and certain debt holders. In addition, we can make no assurances with respect to what the value of our debt and equity will be following the consummation of any refinancing or restructuring. The issuance and sale of substantial amounts of common stock or the announcement that such issuances and sales may occur, could adversely affect the market price of our common stock.

Failure to complete a refinancing or restructuring of our existing debt may limit our ability to fund our operations, meet our obligations and continue as a going concern.

We continue to evaluate our financial and strategic alternatives, which may include a private restructuring of our existing debt or reorganization under Chapter 11 of the Bankruptcy Code. We are currently negotiating with a group of note holders of the Treximet Secured Notes and a group of note holders of the 4.25% Convertible Notes. We are proposing an exchange of both the Treximet Secured Notes and the 4.25% Convertible Notes into a package of new securities, including debt securities, preferred equity securities, common stock and warrants to purchase common stock. We, along with our advisors, are actively working toward such a transaction that would address our existing debt. If we fail to successfully complete a restructuring or refinancing of our existing debt, our indebtedness may be accelerated and we may not be able to otherwise source adequate liquidity to fund our operations, meet our obligations (including our debt payment obligations) and continue as a going concern. In such an event, we may be forced to seek relief under Chapter 11 of the Bankruptcy Code (or an involuntary petition for bankruptcy relief or similar creditor action may be filed against it). We cannot provide assurance that we will be successful in completing a refinancing or restructuring of our existing debt in a private, out-of-court transaction.

42


Recent changes in senior management and the reductions in workforce associated with our restructuring efforts could disrupt the operation of our business, distract our management from focusing on revenue-generating efforts, result in the erosion of employee morale, and impair our ability to respond rapidly to growth opportunities in the future.

We have experienced a number of recent changes in senior management and other key personnel, including the departure of our President and Chief Executive Officer, our Chief Financial Officer, our Chief Operating Officer, and our General Counsel. Our new Chief Executive Officer was appointed on a permanent basis in July 2016 after serving as interim Chief Executive Officer since May 2016 and our new President and Chief Financial Officer was appointed in July 2016, after serving as a senior advisor to the Board since May 2016. The recruitment and retention of a new senior management staff has created and could continue to create a number of transitional challenges for us. These transitional issues have caused, and may cause, disruptions to our business. We cannot be assured that a smooth transition of our senior management staff has occurred, or that we have taken the necessary steps to effect an orderly continuation of our operations during the transitional period. Further, the process of locating personnel with the combination of skills and attributes required to carry out our goals and integrating such personnel once they are recruited is often lengthy. We cannot be assured that the integration of our new senior management staff will occur in a timely manner, or that such integration will not present additional transitional challenges for us or adversely affect the operation of our business.

Moreover, we have implemented a number of recent restructuring plans, including the most recent restructuring activities in July 2016 that resulted in personnel reduction of approximately 23%, primarily through a reduction of sales positions. The employee reductions and changes in connection with our restructuring activities, as well as future changes in senior management and key personnel, could result in an erosion of morale, and affect the focus and productivity of our remaining employees, including those directly responsible for revenue generation and the management and administration of our finances, which in turn may adversely affect our revenue in the future or cause other administrative deficiencies. Additionally, employees directly affected by the reductions may seek future employment with our business partners, customers or competitors. We may face wrongful termination, discrimination, or other claims from employees affected by the reduction related to their employment and termination. We could incur substantial costs in defending ourselves or our employees against such claims, regardless of the merits of such actions. Furthermore, such matters could divert the attention of our employees, including management, away from our operations, harm productivity, harm our reputation and increase our expenses. We cannot assure you that our restructuring efforts will be successful, and we may need to take additional restructuring efforts, including additional personnel reduction, in the future.

ITEM 2. UNREGISTERED SALES OF EQUITY SECURITIES AND USE OF PROCEEDS

None.

ITEM 3. DEFAULTS UPON SENIOR SECURITIES

None.

ITEM 4. MINE SAFETY DISCLOSURES

Not applicable.

ITEM 5. OTHER INFORMATION

None.

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ITEM 6.EXHIBITS

EXHIBIT INDEX

Exhibit No.

  

Description

  

  

  

3.1* 

  

Articles of Incorporation of Pernix Therapeutics Holdings, Inc., as amended .

  

  

  

3.2* 

  

Bylaws of Pernix Therapeutics Holdings, Inc., as amended .

  

  

  

10.1* 

  

Resignation and Release Agreement, dated July 26, 2016, by and between Pernix Therapeutics Holdings, Inc. and Barry Siegel .

  

  

  

31.1* 

  

Certification of the Registrant's Chief Executive Officer pursuant to Section 302 of the Sarbanes-Oxley Act of 2002 .

  

  

  

31.2* 

  

Certification of the Registrant's Principal Financial Officer pursuant to Section 302 of the Sarbanes-Oxley Act of 2002 .

  

  

  

32.1* 

  

Certification of the Registrant's Chief Executive Officer and Principal Financial Officer pursuant to Section 906 of the Sarbanes-Oxley Act of 2002 .

  

  

  

101*

  

Attached as Exhibit 101 to this report are the following items formatted in XBRL (Extensible Business Reporting Language):

  

  

(i) Condensed Consolidated Balance Sheets as of September 30, 2016 and December 31, 2015;

  

  

(ii) Condensed Consolidated Statements of Operations for the Three and Nine Months Ended September 30, 2016 and 2015;

  

  

(iii) Condensed Consolidated Statements of Cash Flows for the Nine Months Ended September 30, 2016 and 2015 and

  

  

(iv) Notes to Condensed Consolidated Financial Statements.

_______________________

*   Filed herewith.

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SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the Registrant has duly caused this report to be signed on its behalf by the undersigned thereunto duly authorized.

  

PERNIX THERAPEUTICS HOLDINGS, INC.

  

  

  

  

  

Date: November 10, 2016

By:

/s/ JOHN SEDOR

  

  

  

John Sedor

  

  

  

Chairman and Chief Executive Officer
(Principal Executive Officer)

  

  

  

  

  

Date: November 10, 2016

By:

/s/ GRAHAM MIAO

  

  

  

Graham Miao
President and Chief Financial Officer

  

  

  

(Principal Financial Officer)

 

  

 

 

 

45


EXHIBIT 3.1
ARTICLES OF INCORPORATION
OF
PERNIX THERAPEUTICS HOLDINGS, INC.
 
As in effect on March 10, 2010
 
ARTICLE I
 
NAME
 
The name of the corporation (which is hereinafter called the “ Corporation ”) is:
 
Pernix Therapeutics Holdings, Inc.
 
ARTICLE II
 
PURPOSES
 
(a) The purpose for which the Corporation is formed is to engage in any lawful act or activity for which corporations may be organized under the General Laws of the State of Maryland now or hereafter in force.
 
(b) The foregoing enumerated purposes and objects shall be in no way limited or restricted by reference to, or inference from, the terms of any other clause of this or any other Article of these Articles of Incorporation of the Corporation (this “ Charter ”), and each shall be regarded as independent; and they are intended to be and shall be construed as powers as well as purposes and objects of the Corporation and shall be in addition to and not in limitation of the general powers of corporations under the General Laws of the State of Maryland.
 
ARTICLE III
 
PRINCIPAL OFFICE IN MARYLAND
 
AND RESIDENT AGENT
 
The post office address of the principal office of the Corporation in the State of Maryland is The Corporation Trust Incorporated, 300 East Lombard Street, Baltimore, Maryland 21202.  The name of the resident agent of the Corporation in the State of Maryland is The Corporation Trust Incorporated, 300 East Lombard Street, Baltimore, Maryland 21202.  Said resident agent is a resident of the State of Maryland.
 
 
1

 
 
ARTICLE IV
 
SHARES OF CAPITAL STOCK
 
SECTION 1.   Authorized Shares of Capital Stock.
 
(a) Authorized Shares .  The total number of shares of capital stock of all classes that the Corporation has authority to issue is one hundred million (100,000,000) shares of capital stock (par value one cent ($.01) per share), consisting of (i) ninety million (90,000,000) shares of common stock, par value one cent ($.01) per share (the “ Common Stock ”), and (ii) ten million (10,000,000) shares of preferred stock, par value one cent ($.01) per share (the “ Preferred Stock ”).  The Preferred Stock includes one million (1,000,000) shares of Series B Junior Participating Stock, par value one cent ($.01) per share (the “ Series B ”).  The remainder of the Preferred Stock may be issued in one or more classes as described in Section 3(b) of this Article IV .  The Common Stock and each class of the Preferred Stock shall each constitute a separate class of capital stock of the Corporation.  The Board of Directors may classify and reclassify any unissued shares of capital stock in accordance with Section 4 of this Article IV .
 
(b) Terminology and Aggregate Par Value .  The Common Stock and Preferred Stock are collectively referred to herein as the “ Equity Shares ”. The aggregate par value of all the Corporation’s authorized Equity Shares having par value is $1,000,000.
 
SECTION 2. Common Stock. Subject to the provisions of Section 3 of this Article IV , the Common Stock shall have the following preferences, conversion and other rights, voting powers, restrictions, limitations as to dividends, qualifications and terms and conditions of redemption and such other rights as may be afforded by law.
 
(a) Voting Rights .  Except as may otherwise be required by law, each holder of Common Stock shall have one vote in respect of each share of Common Stock on all actions to be taken by the stockholders of the Corporation, and, except as otherwise provided in Section 3 of this Article IV or in respect of any class of stock, hereafter classified or reclassified, the exclusive voting power for all purposes shall be vested in the holders of the Common Stock.
 
(b) Dividend Rights .  Subject to the provisions of law, Section 3 of this Article IV and any preferences of any class of stock hereafter classified or reclassified, dividends, including dividends payable in shares of another class of the Corporation’s stock, may be paid on the Common Stock of the Corporation at such time and in such amounts as the Board of Directors may deem advisable and the holders of the Common Stock shall share ratably in any such dividends, in proportion to the number of shares of Common Stock held by them respectively, on a share for share basis.
 
(c) Liquidation Rights .  In the event of any liquidation, dissolution or winding up of the Corporation, whether voluntary of involuntary, the holders of the Common Stock shall be entitled, after payment or provision for payment of the debts and other liabilities of the Corporation and the amount to which the holders of the Series B and the holders of any class of capital stock hereafter classified or reclassified having a preference on distributions in the liquidation, dissolution or winding up on the Corporation are entitled, together with the holders of the Series B and the holders of any other class of capital stock hereafter classified or reclassified not having a preference on distributions in the liquidation, dissolution or winding up of the Corporation, to share ratably in the remaining net assets of the Corporation.
 
 
2

 
 
(d) Stock Exchange Transactions .  Notwithstanding any provisions contained herein to the contrary, nothing in this Charter shall preclude the settlement of any transaction entered into through the facilities of the New York Stock Exchange or the American Stock Exchange.
 
SECTION 3. Preferred Shares .
 
(a)  Series B Junior Participating Preferred Stock .  The Series B shall have the following preferences, conversion and other rights, voting powers, restrictions, limitations as to dividends, qualifications and terms and conditions of redemption and such other rights as may be afforded by law.
 
(i)  Dividends and Distributions .
 
(A) Subject to the prior and superior rights of the holders of any shares of any series of Preferred Stock ranking prior and superior to the shares of the Series B with respect to dividends, the holders of shares of the Series B shall be entitled to receive, when, as and if authorized and declared by the Board of Directors out of funds legally available for the purpose, quarterly dividends payable in cash on the 15th day of January, April, July and October in each year, or the next following business day, if such day is not a business day (each such date being referred to herein as a “ Quarterly Dividend Payment Date ”), commencing on the first Quarterly Dividend Payment Date after the first issuance of a share or fraction of a share of the Series B, in an amount per share (rounded to the nearest cent) equal to the greater of (1) $1.00, or (2) subject to the provision for adjustment hereinafter set forth, 100 times the aggregate per share amount of all cash dividends, and 100 times the aggregate per share amount (payable in kind) of all non-cash dividends or other distributions other than a dividend payable in shares of Common Stock or a subdivision of the outstanding shares of Common Stock (by reclassification or otherwise), declared on the Common Stock since the immediately preceding Quarterly Dividend Payment Date, or, with respect to the first Quarterly Dividend Payment Date, since the first issuance of any share or fraction of a share of the Series B.  In the event the Corporation shall at any time after September 6, 1999 (the “ Rights Record Date ”) (x) authorize and declare any dividend on the Common Stock payable in shares of the Common Stock, (y) subdivide the outstanding Common Stock, or (z) combine the outstanding Common Stock into a smaller number of shares, then in each such case the amount to which holders of shares of the Series B were entitled immediately prior to such event under clause (2) of the preceding sentence shall be adjusted by multiplying such amount by a fraction the numerator of which is the number of shares of Common Stock outstanding immediately after such event and the denominator of which is the number of shares of Common Stock that were outstanding immediately prior to such event.
 
(B)   The Corporation shall authorize and declare a dividend or distribution on the Series B as provided in Section 3(a)(i)(A) of this Article IV  immediately after it authorizes and declares a dividend or distribution on the Common Stock (other than a dividend payable in shares of Common Stock); provided that, in the event no dividend or distribution shall have been authorized and declared on the Common Stock during the period between any Quarterly Dividend Payment Date and the next subsequent Quarterly Dividend Payment Date, a dividend of $1.00 per share on the Series B shall nevertheless be payable on such subsequent Quarterly Dividend Payment Date.
 
 
3

 
 
(C)   Dividends shall begin to accrue and be cumulative on outstanding shares of the Series B from the Quarterly Dividend Payment Date next preceding the date of issue of such shares of the Series B, unless the date of issue of such shares is prior to the record date for the first Quarterly Dividend Payment Date, in which case dividends on such shares shall begin to accrue from the date of issue of such shares, or unless the date of issue is a Quarterly Dividend Payment Date or is a date after the record date for the determination of holders of shares of the Series B entitled to receive a quarterly dividend and before such Quarterly Dividend Payment Date, in either of which events such dividends shall begin to accrue and be cumulative from such Quarterly Dividend Payment Date.  Accrued but unpaid dividends shall not bear interest.  Dividends paid on the shares of the Series B in an amount less than the total amount of such dividends at the time accrued and payable on such shares shall be allocated pro rata on a share-by-share basis among all such shares at the time outstanding.  The Board of Directors may fix a record date for the determination of holders of shares of the Series B entitled to receive payment of a dividend or distribution authorized and declared thereon, which record date shall be no more than 30 days prior to the date fixed for the payment thereof.
 
(ii) Voting Rights .  The holders of shares of the Series B shall have the following voting rights:
 
(A) Subject to the provision for adjustment hereinafter set forth, each share of the Series B shall entitle the holder thereof to 100 votes on all matters submitted to a vote of the holders of the Common Stock.  In the event the Corporation shall at any time after the Rights Record Date (1) authorize and declare any dividend on Common Stock payable in shares of Common Stock, (2) subdivide the outstanding Common Stock, or (3) combine the outstanding Common Stock into a smaller number of shares, then in each such case the number of votes per share to which holders of shares of the Series B were entitled immediately prior to such event shall be adjusted by multiplying such number by a fraction the numerator of which is the number of shares of Common Stock outstanding immediately after such event and the denominator of which is the number of shares of Common Stock that were outstanding immediately prior to such event.
 
(B)  Except as otherwise provided herein, the holders of shares of the Series B and the holders of shares of Common Stock shall vote together as one class on all matters submitted to a vote of holders of the Common Stock.
 
(C)   Default Period .
 
(1)   If at any time dividends on any of the Series B shall be in arrears in an amount equal to six (6) quarterly dividends thereon, the occurrence of such contingency shall mark the beginning of a period (herein called a “ Default Period ”) which shall extend until such time when all accrued and unpaid dividends for all previous quarterly dividend periods and for the current quarterly dividend period on all shares of the Series B then outstanding shall have been authorized and declared and paid or set apart for payment.  During each Default Period, all holders of Preferred Stock (including holders of the Series B) with dividends in arrears in an amount equal to six (6) quarterly dividends thereon, voting as a class, irrespective of series, shall have the right to elect two (2) directors.
 
 
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(2)   During any Default Period, such voting right of the holders of the Series B may be exercised initially at a special meeting called pursuant to Section 3(a)(ii)(C)(3) of this Article IV or at any annual meeting of stockholders, and thereafter at annual meetings of stockholders, provided that neither such voting right nor the right of the holders of any other series of Preferred Stock, if any, to increase, in certain cases, the authorized number of directors, be exercised unless the holders of ten percent (10%) in number of shares of Preferred Stock outstanding be present in person or by proxy.  The absence of a quorum of the holders of Common Stock shall not affect the exercise by the holders of Preferred Stock of such voting right.  At any meeting at which the holders of Preferred Stock shall exercise such voting right initially during an existing Default Period, they shall have the right, voting as a class, to elect directors to fill such vacancies, if any, in the Board of Directors as may then exist up to two (2) directors or, if such right is exercised at an annual meeting, to elect two (2) directors.  If the number which may be so elected at any special meeting does not amount to the required number, the holders of the Preferred Stock shall have the right to make such increase in the number of directors as shall be necessary to permit the election by them of the required number.  After the holders of the Preferred Stock shall have exercised their right to elect directors in any Default Period and during the continuance of such period, the number of directors shall not be increased or decreased except by vote of the holders of Preferred Stock as herein provided or pursuant to the rights of any equity securities ranking senior to or pari passu with the Series B.
 
(3) Unless the holders of Preferred Stock shall, during an existing Default Period, have previously exercised their right to elect directors, the Board of Directors may order, or any stockholder or stockholders owning in the aggregate not less than ten percent (10%) of the total number of shares of Preferred Stock outstanding, irrespective of series, may request, the calling of a special meeting of the holders of Preferred Stock, which meeting shall thereupon be called by the President, a Vice-President or the Secretary of the Corporation.  Notice of such meeting and of any annual meeting at which holders of Preferred Stock are entitled to vote pursuant to this Section 3(a)(ii)(C)(3) shall be given to each holder of record of Preferred Stock by mailing a copy of such notice to him at his last address as the same appears on the books of the Corporation.  Such meeting shall be called for a time not earlier than 20 days and not later than 60 days after such order or request or in default of the calling of such meeting within 60 days after such order or request, such meeting may be called on similar notice by any stockholder or stockholders owning in the aggregate not less than ten percent (10%) of the total number of shares of Preferred Stock outstanding.  Notwithstanding the provisions of this Section 3(a)(ii)(C)(3) , no such special meeting shall be called during the period within 60 days immediately preceding the date or the first day of the period, as the case may be, fixed by the Bylaws of the Corporation for the next annual meeting of the stockholders.
 
(4)   In any Default Period, the holders of Common Stock, and other classes of stock of the Corporation if applicable, shall continue to be entitled to elect the whole number of directors until the holders of Preferred Stock shall have exercised their right to elect two (2) directors voting as a class, after the exercise of which right (x) the directors so elected by the holders of Preferred Stock shall continue in office until their successors shall have been elected by such holders or until the expiration of the Default Period, whichever happens first, and (y) any vacancy in the Board of Directors may (except as provided in Section 3(a)(ii)(C)(2) of this Article IV ) be filled by vote of a majority of the remaining directors theretofore elected by the holders of the class of stock which elected the director whose office shall have become vacant.  References in this Section 3(a)(ii)(C) to directors elected by the holders of a particular class of stock shall include directors elected by such directors to fill vacancies as provided in clause (y) of the foregoing sentence.
 
 
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(5)   Immediately upon the expiration of a Default Period, (x) the right of the holders of Preferred Stock as a class to elect directors shall cease, (y) the term of any directors elected by the holders of Preferred Stock as a class shall terminate, and (z) the number of directors shall be such number as may be provided for in this Charter or Bylaws irrespective of any increase made pursuant to the provisions of Section 3(a)(ii)(C)(2) of this Article IV (such number being subject, however, to change thereafter in any manner provided by law or in this Charter or Bylaws).  Any vacancies in the Board of Directors effected by the provisions of clauses (y) and (z) in the preceding sentence may be filled by a majority of the remaining directors.
 
(D)   Except as set forth herein, holders of the Series B shall have no special voting rights and their consent shall not be required (except to the extent they are entitled to vote with holders of Common Stock as set forth herein) for taking any corporate action.
 
(iii)   Certain Restrictions .
 
(A)   Whenever quarterly dividends or other dividends or distributions payable on the Series B as provided in Section 3(a)(i) of this Article IV are in arrears, thereafter and until all accrued and unpaid dividends and distributions, whether or not authorized or declared, on shares of the Series B outstanding shall have been paid in full, the Corporation shall not:
 
(1)   authorize or declare or pay dividends on, make any other distributions on, or redeem or purchase or otherwise acquire for consideration any shares of stock ranking junior (either as to dividends or upon liquidation, dissolution or winding up) to the Series B;
 
(2)   authorize or declare or pay dividends on or make any other distributions on any shares of stock ranking on a parity (either as to dividends or upon liquidation, dissolution or winding up) with the Series B, except dividends paid ratably on the Series B and all such parity stock on which dividends are payable or in arrears in proportion to the total amounts to which the holders of all such shares are then entitled;
 
(3)   redeem or purchase or otherwise acquire for consideration shares of any stock ranking on a parity (either as to dividends or upon liquidation, dissolution or winding up) with the Series B, provided that the Corporation may at any time redeem, purchase or otherwise acquire shares of any such parity stock in exchange for shares of any stock of the Corporation ranking junior (either as to dividends or upon dissolution, liquidation or winding up) to the Series B; or
 
(4)   purchase or otherwise acquire for consideration any shares of the Series B, or any shares of stock ranking on a parity with the Series B, except in accordance with a purchase offer made in writing or by publication (as determined by the Board of Directors) to all holders of such shares upon such terms as the Board of Directors, after consideration of the respective annual dividend rates and other relative rights and preferences of the respective series and classes, shall determine in good faith will result in fair and equitable treatment among the respective series or classes.
 
 
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(B)   The Corporation shall not permit any subsidiary of the Corporation to purchase or otherwise acquire for consideration any shares of stock of the Corporation unless the Corporation could, under Section 3(a)(iii)(A) of this Article IV , purchase or otherwise acquire such shares at such time and in such manner.
 
(iv) Reacquired Shares .  Any shares of the Series B purchased or otherwise acquired by the Corporation in any manner whatsoever shall be retired and cancelled promptly after the acquisition thereof.  All such shares shall upon their cancellation become authorized but unissued shares of Preferred Stock and may be reissued as part of a new series of Preferred Stock to be created by resolution or resolutions of the Board of Directors, subject to the conditions and restrictions on issuance set forth herein.
 
(v) Liquidation, Dissolution or Winding Up .
 
(A) Upon any liquidation (voluntary or otherwise), dissolution or winding up of the Corporation, no distribution shall be made to the holders of shares of stock ranking junior (either as to dividends or upon liquidation, dissolution or winding up) to the Series B unless, prior thereto, the holders of shares of the Series B shall have received an amount equal to $100 per share of Series B, plus an amount equal to accrued and unpaid dividends and distributions thereon, whether or not authorized or declared, to the date of such payment (the “ Series B Liquidation Preference ”).  Following the payment of the full amount of the Series B Liquidation Preference, no additional distributions shall be made to the holders of shares of the Series B unless, prior thereto, the holders of shares of Common Stock shall have received an amount per share (the “ Common Adjustment ”) equal to the quotient obtained by dividing (1) the Series B Liquidation Preference by (2) 100 (as appropriately adjusted as set forth in Section 3(a)(v)(C) of this Article IV to reflect such events as stock splits, stock dividends and recapitalizations with respect to the Common Stock) (such number in clause (2), the “ Adjustment Number ”).  Following the payment of the full amount of the Series B Liquidation Preference and the Common Adjustment in respect of all outstanding shares of the Series B and Common Stock, respectively, holders of the Series B and holders of shares of Common Stock shall receive their ratable and proportionate share of the remaining assets to be distributed in the ratio of the Adjustment Number to l with respect to such Preferred Stock and Common Stock, on a per share basis, respectively.  The merger or consolidation of the Corporation, regardless of whether the Corporation is the surviving entity in such merger or consolidation, shall not be deemed to be the liquidation, dissolution or winding up of the Corporation.
 
(B) In the event, however, that there are not sufficient assets available to permit payment in full of the Series B Liquidation Preference and the liquidation preferences of all other series of preferred stock, if any, which rank on a parity with the Series B, then such remaining assets shall be distributed ratably in the same proportion as the respective amounts that would be payable on such Series B and any such other parity stock if all amounts payable thereon were paid in full.  In the event, however, that there are not sufficient assets available to permit payment in full of the Common Adjustment, then such remaining assets shall be distributed ratably to the holders of Common Stock.
 
 
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(C)   In the event the Corporation shall at any time after the Rights Record Date (1) declare any dividend on Common Stock payable in shares of Common Stock, (2) subdivide the outstanding Common Stock, or (3) combine the outstanding Common Stock into a smaller number of shares, then in each such case the Adjustment Number in effect immediately prior to such event shall be adjusted by multiplying such Adjustment Number by a fraction the numerator of which is the number of shares of Common Stock outstanding immediately after such event and the denominator of which is the number of shares of Common Stock that were outstanding immediately prior to such event.
 
(vi) Consolidation, Merger, Etc .  If the Corporation shall enter into any consolidation, merger, combination or other transaction in which the shares of Common Stock are exchanged for or changed into other stock or securities, cash and/or any other property, then in any such case the shares of the Series B shall at the same time be similarly exchanged or changed in an amount per share (subject to the provision for adjustment hereinafter set forth) equal to 100 times the aggregate amount of stock, securities, cash and/or any other property (payable in kind), as the case may be, into which or for which each share of Common Stock is changed or exchanged.  In the event the Corporation shall at any time after the Rights Record Date (1) declare any dividend on Common Stock payable in shares of Common Stock, (2) subdivide the outstanding Common Stock, or (3) combine the outstanding Common Stock into a smaller number of shares, then in each such case the amount set forth in the preceding sentence with respect to the exchange or change of shares of the Series B shall be adjusted by multiplying such amount by a fraction the numerator of which is the number of shares of Common Stock outstanding immediately after such event and the denominator of which is the number of shares of Common Stock that were outstanding immediately prior to such event.
 
(vii)  No Redemption .  The shares of the Series B shall not be redeemable.
 
(viii) Ranking .
 
(A)   The Series B shall rank junior to all other series of the Corporation's Preferred Stock as to the payment of dividends and the distribution of assets, unless the terms of any such series shall provide otherwise.
 
(B)   The liquidation preference of the outstanding shares of the Series B will not be added to the liabilities of the Corporation for the purpose of determining whether under the Maryland General Corporation Law a distribution may be made to stockholders of the Corporation whose preferential rights upon dissolution of the Corporation are junior to those of holders of the Series B.
 
(ix) Amendment .  At any time when any shares of the Series B are outstanding, this Charter shall not be amended in any manner which would materially alter or change the powers, preferences or special rights of the Series B so as to affect them adversely without the affirmative vote of the holders of a majority or more of the outstanding shares of the Series B, voting separately as a class; provided that none of (A) the creation or issuance of (1) additional shares of the Series B, or (2) shares of any class or series of Preferred Stock ranking junior to or on parity with the Series B as to the payment of dividends and the distribution of assets, (B) a merger or consolidation in which the Corporation is the surviving entity and the Series B remains outstanding with no material adverse change in its powers, preferences and special rights, or (C) a merger or consolidation in which the Corporation is not the surviving entity and the holders of the Series B receive in exchange therefor a substantially identical security of the surviving entity, shall be considered to materially adversely alter or change the powers, preferences or special powers of the Series B.
 
 
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(x) F ractional Shares .  The Series B may be issued in fractions of a share which shall entitle the holder, in proportion to such holder's fractional shares, to exercise voting rights, receive dividends, participate in distributions and to have the benefit of all other rights of holders of the Series B.
 
(xi) Certificate Legend .  The Board of Directors may authorize the issue of some or all of the shares (including fractional shares) of the Series B without certificates.  If issued in certificated form, each share (including each fractional share) of the Series B shall bear substantially the following legend in addition to any legends required to comply with federal and state securities laws:
 
THE CORPORATION IS AUTHORIZED TO ISSUE CAPITAL STOCK OF MORE THAN ONE CLASS, CONSISTING OF COMMON STOCK AND ONE OR MORE CLASSES OF PREFERRED STOCK.  THE BOARD OF DIRECTORS IS AUTHORIZED TO DETERMINE THE PREFERENCES, LIMITATIONS AND RELATIVE RIGHTS OF ANY CLASS OF PREFERRED STOCK BEFORE THE ISSUANCE OF SHARES OF SUCH CLASS OF PREFERRED STOCK.  THE CORPORATION WILL FURNISH, WITHOUT CHARGE, TO ANY STOCKHOLDER MAKING A WRITTEN REQUEST THEREFORE, A COPY OF THE CORPORATION'S CHARTER AND A WRITTEN STATEMENT OF THE DESIGNATIONS, RELATIVE RIGHTS, PREFERENCES, CONVERSION OR OTHER RIGHTS, VOTING POWERS, RESTRICTIONS, LIMITATIONS AS TO THE DIVIDENDS AND OTHER DISTRIBUTIONS, QUALIFICATIONS AND TERMS AND CONDITIONS OF REDEMPTION OF THE STOCK OF EACH CLASS WHICH THE CORPORATION HAS THE AUTHORITY TO ISSUE AND, IF THE CORPORATION IS AUTHORIZED TO ISSUE ANY PREFERRED OR SPECIAL CLASS IN SERIES, (i) THE DIFFERENCES IN THE RELATIVE RIGHTS AND PREFERENCES BETWEEN THE SHARES OF EACH SERIES TO THE EXTENT SET, AND (ii) THE AUTHORITY OF THE BOARD OF DIRECTORS TO SET SUCH RIGHTS AND PREFERENCES OF SUBSEQUENT SERIES.  REQUESTS FOR SUCH WRITTEN STATEMENT MAY BE DIRECTED TO THE SECRETARY OF THE CORPORATION AT ITS PRINCIPAL OFFICE.
 
(b)   The Preferred Stock may be issued from time to time in one or more classes.  The Board of Directors is expressly authorized, in the resolution or resolutions providing for the issuance of any wholly unissued class of Preferred Stock, to fix, state and express the powers, rights, designations, preferences, qualifications, limitations and restrictions thereof, including without limitation (i) the rate of dividends upon which and the times at which dividends on shares of such class shall be payable and the preference, if any, which such dividends shall have relative to dividends on shares of any other class or classes of stock of the Corporation, (ii) whether such dividends shall be cumulative or noncumulative, and if cumulative, the date or dates from which dividends on shares of such class shall be cumulative, (iii) the voting rights, if any, to be provided for shares of such class, (iv) the rights, if any, which the holders of shares of such class shall have in the event of any voluntary or involuntary liquidation, dissolution or winding up of the affairs of the Corporation, (v) the rights, if any, which the holders of shares of such class shall have to convert such shares into or exchange such shares for shares of stock of the Corporation, and the terms and conditions, including price and rate of exchange of such conversion or exchange, (vi) the redemption rights (including sinking fund provisions), if any, for shares of such class, and (vii) such other powers, rights, designations, preferences, qualifications, limitations and restrictions as the Board of Directors may desire to so fix.  The Board of Directors is also expressly authorized to fix the number of shares constituting such class and to increase or decrease the number of shares of any class prior to the issuance of shares of that class and to increase or decrease the number of shares of any class subsequent to the issuance of shares of that class, but not to decrease such number below the number of shares of such class then outstanding.  In case the number of shares of any class shall be so decreased, the shares constituting such decrease shall resume the status which they had prior to the adoption of the resolution originally fixing the number of shares of such class.
 
 
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SECTION 4. Classification and Reclassification of Capital Stock .
 
(a) Subject to the foregoing provisions of this Article IV , the power of the Board of Directors to classify and reclassify any of the unissued shares of capital stock shall include, without limitation, subject to the provisions of this Charter, authority to classify or reclassify any unissued shares of such stock into a class or classes of preferred stock, preference stock, special stock or other stock, by determining, fixing or altering one or more of the following:
 
(i) The distinctive designation of such class and the number of shares to constitute such class, provided that, unless otherwise prohibited by the terms of such or any other class, the number of shares of any class may be decreased by the Board of Directors in connection with any classification or reclassification of unissued shares and the number of shares of such class may be increased by the Board of Directors in connection with any such classification or reclassification, and any shares of any class which have been redeemed, purchased, otherwise acquired or converted into Common Stock or any other class shall become part of the authorized capital stock and be subject to classification and reclassification as provided in this Section 4 of Article IV .
 
(ii) Whether or not and, if so, the rates, amounts and times at which, and the conditions under which, dividends shall be payable on shares of such class, whether any such dividends shall rank senior or junior to or on a parity with the dividends payable on any other class of stock, and the status of any such dividends as cumulative, cumulative to a limited extent or non-cumulative and as participating or non- participating.
 
(iii) Whether or not shares of such class shall have voting rights, in addition to any voting rights provided by law and, if so, the terms of such voting rights.
 
 
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(iv) Whether or not shares of such class shall have conversion or exchange privileges and, if so, the terms and conditions thereof, including provision for adjustment of the conversion or exchange rate in such events or at such times as the Board of Directors shall determine.
 
(v) Whether or not shares of such class shall be subject to redemption and, if so, the terms and conditions of such redemption, including the date or dates upon or after which they shall be redeemable and the amount per share payable in case of redemption, which amount may vary under different conditions and at different redemption dates; and whether or not there shall be any sinking fund or purchase account in respect thereof, and if so, the terms thereof.
 
(vi) The rights of the holders of shares of such class upon the liquidation, dissolution or winding up of the affairs of, or upon any distribution of the assets of, the Corporation, which rights may vary depending upon whether such liquidation, dissolution or winding up is voluntary or involuntary and, if voluntary, may vary at different dates, and whether such rights shall rank senior or junior to or on a parity with such rights of any other class of stock.
 
(vii) Whether or not there shall be any limitations applicable, while shares of such class are outstanding, upon the payment of dividends or making of distributions on, or the acquisition of, or the use of moneys for purchase or redemption of, any stock of the Corporation, or upon any other action of the Corporation, including action under this Section 4 of Article IV , and, if so, the terms and conditions thereof.
 
(viii) Any other preferences, rights, restrictions, including restrictions on transferability, and qualifications of shares of such class, not inconsistent with law and this Charter of the Corporation.
 
(b) For the purposes hereof and of any articles supplementary to this Charter providing for the classification or reclassification of any shares of capital stock or of any other Charter document of the Corporation (unless otherwise provided in any such articles or document), any class of stock of the Corporation shall be deemed to rank:
 
(i) prior to another class either as to dividends or upon liquidation, if the holders of such class shall be entitled to the receipt of dividends or of amounts distributable on liquidation, dissolution or winding up, as the case may be, in preference or priority to holders of such other class;
 
(ii)   on a parity with another class either as to dividends or upon liquidation, whether or not the dividend rates, dividend payment dates or redemption or liquidation price per share thereof be different from those of such others, if the holders of such class of stock shall be entitled to receipt of dividends or amounts distributable upon liquidation, dissolution or winding up, as the case may be, in proportion to their respective dividend rates or redemption or liquidation prices, without preference or priority over the holders of such other class; and
 
 
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(iii)   junior to another class either as to dividends or upon liquidation, if the rights of the holders of such class shall be subject or subordinate to the rights of the holders of such other class in respect of the receipt of dividends or the amounts distributable upon liquidation, dissolution or winding up, as the case may be.
 
SECTION 5. Settlement. Nothing in this Article IV shall be interpreted to preclude the settlement of any transaction entered into through the facilities of the New York Stock Exchange, the American Stock Exchange, any other national securities exchange or The Nasdaq National Market system, but the Equity Shares which are the subject of such transaction shall continue to be subject to the terms of this Article IV subsequent to such settlement.
 
SECTION 6. BOARD OF DIRECTORS’ AUTHORITY TO EFFECT REVERSE STOCK SPLITS. . Notwithstanding any other provision of these Articles of Incorporation, to the fullest extent permitted under applicable law, the board of directors of the Corporation shall have the power to effect, without stockholder action or approval, any reverse stock split.
 
ARTICLE V
 
THE BOARD OF DIRECTORS
 
SECTION 1. Number and Qualification of Directors. The business and affairs of the Corporation shall be managed by a Board of Directors which may exercise all of the powers of the Corporation except those conferred on, or reserved to, the stockholders hereunder, under the Bylaws or by law.  The current number of seats on the Board of Directors is seven (7), which number may be increased or decreased pursuant to the Bylaws of the Corporation but in no event shall be less than the minimum number required by the general laws of the State of Maryland.  A director need not be a stockholder of the Corporation.  The names of the directors who will serve until the next annual meeting and until their successors are elected and qualify are as follows:
 
W. Bradley Blair, II
Jan H. Loeb
Nauman S. Toor
Edward L. Wax
Michael C. Pearce
 
 
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SECTION 2. Removal of Directors. Any director may be removed with or without cause by the affirmative vote of stockholders holding not less than 66-2/3% of all votes entitled to be cast for the election of directors, subject to any rights granted to any class of Preferred Stock.
 
SECTION 3. Filling Vacancies. Except in the case of a vacancy on the Board of Directors among the directors elected by a class of Equity Shares other than Common Stock, any vacancy on the Board of Directors may be filled by the affirmative vote of the remaining directors (except that a vacancy which results from an increase in the number of directors may be filled by a majority of the entire Board of Directors), and, in the case of a vacancy resulting from the removal of a director, by the stockholders by the vote of a majority of the votes entitled to be cast in the election of directors, subject to any rights granted to any class of Preferred Stock.
 
SECTION 4.   No Cumulative Voting. Stockholders shall not be entitled to cumulative voting rights with respect to the election of directors.
 
SECTION 5. Reserved Powers of the Board of Directors. The enumeration and definition of particular powers of the Board of Directors included in the foregoing provisions of this Article V or the provisions of Article VI of this Charter shall in no way be limited or restricted by reference to or inference from the terms of any other clause of this or any other Article of this Charter of the Corporation, or construed as or deemed by inference or otherwise in any manner to exclude or limit any powers conferred upon the Board of Directors under the General Laws of the State of Maryland now or hereafter in force.
 
SECTION 6. Independent Directors .
 
(a) Except during a period not to exceed sixty (60) days following the death, resignation, incapacity or removal from office of a Director prior to the expiration of the Director’s term of office, a majority of the Directors shall be Independent Directors at all times.
 
(b) An Independent Director shall be a person who is not:  (i) an officer or employee of the Corporation, or (ii) an Affiliate of (w) any advisor to the Corporation under an advisory agreement, (x) any lessee or management company operating any property of the Corporation, (y) any subsidiary of the Corporation, or (z) any partnership which is an Affiliate of the Corporation.
 
(c) For purposes of this Section 6 of Article V , an “ Affiliate ” of a person or entity shall mean (i) any person that, directly or indirectly, controls or is controlled by or is under common control with such person, (ii) any other person that owns, beneficially, directly or indirectly, five percent (5%) or more of the outstanding capital shares, shares or equity interests of such person, or (iii) any officer, director, employee, partner or trustee of such person or any person controlling, controlled by or under common control with such person (excluding trustees and persons serving in similar capacities who are not otherwise an Affiliate of such person).  
 
 
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The term “ person ” means and includes individuals, corporations, general and limited partnerships, stock companies or associations, joint ventures, associations companies, trusts, banks, trust companies, last trusts, business trusts or other entities and governments and agencies and political subdivisions thereof.  For the purposes of this definition, “ control ” (including the correlative meanings of the terms “ controlled by ” and “ under common control with ”, as used with respect to any person, shall mean the possession, directly or indirectly, of the power to direct or cause the direction of the management and policies of such person, through the ownership of voting securities, partnership interests or other equity interests.
 
(d) Notwithstanding the foregoing requirement that a majority of the directors be Independent Directors, no action otherwise validly taken by the Board of Directors during a period in which a majority of its members are not Independent Directors shall be invalidated or otherwise affected by such circumstance, nor shall such circumstance subject the directors taking any such action to a higher standard of care or to liability other than that which would have applied to such action had a majority of the members of the Board of Directors been Independent Directors at the time such action was taken.
 
ARTICLE VI
 
PROVISIONS FOR DEFINING, LIMITING AND REGULATING
 
CERTAIN POWERS OF THE CORPORATION AND OF THE
 
STOCKHOLDERS AND DIRECTORS
 
The following provisions are hereby adopted for the purpose of defining, limiting and regulating the powers of the Corporation and of the directors and stockholders:
 
SECTION 1. Board Authorization of Share Issuances .  The Board of Directors is hereby empowered to authorize the issuance from time to time of shares of any class of Equity Shares, whether now or hereafter authorized, or securities convertible into any class of Equity Shares, whether now or hereafter authorized, for such consideration as may be deemed advisable by the Board of Directors and without any action by the stockholders.
 
SECTION 2. No Preemptive Rights .  Except as provided by the Board of Directors in authorizing the issuance of Preferred Stock pursuant to Section 3(b) of Article IV, no holder of any stock or any other securities of the Corporation, whether now or hereafter authorized, shall have any preemptive right to subscribe to or purchase (a) any shares of capital stock of the Corporation, (b) any warrants, rights or options to purchase any such shares, or (c) any other securities of the Corporation or obligations convertible into any shares of capital stock of the Corporation or such other securities or into warrants, rights or options to purchase any such shares or other securities.
 
SECTION 3. Powers of the Board of Directors .The Board of Directors of the Corporation shall, consistent with applicable law, have the power in its sole discretion to determine from time to time in accordance with sound accounting practice or other reasonable valuation methods what constitutes annual or other net profits, earnings, surplus or net assets in excess of capital; to fix and vary from time to time the amount to be reserved as working capital, or determine that retained earnings or surplus shall remain in the hands of the Corporation; to set apart out of any funds of the Corporation such reserve or reserves in such amount or amounts and for such proper purpose or purposes as it shall determine and to abolish any such reserve or any part thereof; to distribute and pay distributions or dividends in stock, cash or other securities or property, out of surplus or any other funds or amounts legally available therefor, at such times and to the stockholders of record on such dates as it may, from time to time, determine; and to determine whether and to what extent and at what times and places and under what conditions and regulations the books, accounts and documents of the Corporation, or any of them, shall be open to the inspection of stockholders, except as otherwise provided by statute or by the Bylaws of the Corporation, and, except as so provided, no stockholder shall have any right to inspect any book, account or document of the Corporation unless authorized so to do by resolution of the Board of Directors.
 
 
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SECTION 4. Related Party Transactions .  Without limiting any other procedures available by law or otherwise to the Corporation, the Board of Directors may authorize any agreement or transaction with any Person, corporation, association, company, trust, partnership (limited or general) or other organization, although one or more of the directors or officers of the Corporation may be a party to any such agreement or an officer, director, stockholder or member of such other party (an “ Interested Officer/Director ”), and no such agreement or transaction shall be invalidated or rendered void or voidable solely by reason of the existence of any such relationship if (a) the existence is disclosed or known to the Board of Directors, and the contract or transaction is authorized, approved or ratified by the affirmative vote of a majority of the directors, excluding the Interested Officers/Directors, (b) the existence is disclosed to the stockholders entitled to vote, and the contract or transaction is authorized, approved or ratified by a majority of the votes entitled to be cast by the stockholders, other than the votes of the shares held of record by the Interested Officers/Directors, or (c) the contract or transaction of fair and reasonable to the Corporation.  Any Interested Officer/Director of the Corporation or the stock owned by them or by a corporation, association, company, trust, partnership (limited or general) or other organization in which an Interested Officer/Director may have an interest, may be counted in determining the presence of a quorum at a meeting of the Board of Directors or a committee of the Board of Directors or at a meeting of the stockholders, as the case may be, at which the contract or transaction is authorized, approved or ratified.
 
ARTICLE VII
 
INDEMNIFICATION
 
AND LIMITATION OF LIABILITY
 
SECTION 1. Indemnification .
 
(a) Indemnification of Agents .  The Corporation shall indemnify, in the manner and to the fullest extent permitted by law, any person (or the estate of any person) who is or was a party to, or is threatened to be made a party to, any threatened, pending or completed action, suit or proceeding, whether or not by or in the right of the Corporation, and whether civil, criminal, administrative, investigative or otherwise, by reason of the fact that such person is or was a director or officer of the Corporation, or such director or officer is or was serving at the request of the Corporation as a director, officer, agent, trustee, partner or employee of another corporation, partnership, joint venture, limited liability company, trust, real estate investment trust, employee benefit plan or other enterprise.  To the fullest extent permitted by law, the indemnification provided herein shall include expenses (including attorneys’ fees), judgments, fines and amounts paid in settlement and any such expenses shall be paid by the Corporation in advance of the final disposition of such action, suit or proceeding.  The Corporation shall indemnify other employees and agents to such extent as shall be authorized by the Board of Directors or the Corporation’s Bylaws and be permitted by law.  Any repeal or modification of this Section 1(a) by the stockholders of the Corporation shall be prospective only, and shall not adversely affect any right to indemnification or advancement of expenses hereunder existing at the time of such repeal or modification.
 
 
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(b) Insurance .  The Corporation shall, to the fullest extent permitted by law, purchase and maintain insurance on behalf of any such person against any liability which may be asserted against such person.
 
(c) Indemnification Non- Exclusive .  The indemnification provided herein shall not be deemed to limit the right of the Corporation to indemnify any other person for any such expenses to the fullest extent permitted by law, nor shall it be deemed exclusive of any other rights to which any person seeking indemnification from the Corporation may be entitled under any agreement, vote of stockholders or disinterested directors, or otherwise, both as to action in such person’s official capacity and as to action in another capacity while holding such office.
 
SECTION 2. Limitation of Liability .  To the fullest extent permitted by Maryland statutory or decisional law, as amended or interpreted from time to time, no director or officer of this Corporation shall be personally liable to the Corporation or its stockholders, or any of them, for money damages.  No amendment of this Charter or repeal of any of its provisions shall limit or eliminate the benefits provided to directors and officers under this provision with respect to any act or omission which occurred prior to such amendment or repeal.
 
ARTICLE VIII
 
AMENDMENTS
 
SECTION 1. Right to Amend Charter .  The Corporation reserves the right from time to time to make any amendments to this Charter which may now or hereafter be authorized by law, including any amendments changing the terms or contract rights, as expressly set forth in this Charter, of any of its outstanding stock by classification, reclassification or otherwise.
 
SECTION 2. Amendment to the Charter of the Corporation .  Notwithstanding any provision of law to the contrary, except as otherwise specifically provided in Section 3 of this Article VIII , the affirmative vote of a majority of all votes entitled to be cast by the stockholders of the Corporation shall be sufficient, valid and effective, after due authorization, approval or advice by the Board of Directors, to approve and authorize any amendment to this Charter.
 
SECTION 3. Certain Amendments Requiring Special Stockholder Vote .
 
(a) Notwithstanding any other provisions of this Charter or Bylaws of the Corporation (and in addition to any other vote, approval, authorization or advice, including that of the Board of Directors, that may be required by law, this Charter or the Bylaws of the Corporation), the affirmative vote of stockholders holding at least two-thirds (66-2/3%) of all of the votes entitled to be cast thereon shall be required to amend, alter, change, repeal or adopt any provisions inconsistent with the provisions of this Section 2 of Article V (removal of directors), Section 4 of Article V (no cumulative voting), Section 6 of Article V (Independent Directors), Section 2 of Article VI (preemptive rights), Article VII and Article VIII .
 
 
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(b) The Board of Directors shall take no action to amend the provisions of Article IV until such time as (i) the Board of Directors adopts a resolution recommending that the Corporation amend Article IV , (ii) the Board of Directors presents the resolution at an annual or special meeting of the stockholders, and (iii) such resolution is approved by at least two-thirds (66-2/3%) of all of the votes entitled to be cast on the matter.
 
ARTICLE IX
 
DURATION OF CORPORATION
 
The duration of the Corporation shall be perpetual.
 
 
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Exhibit 3.1

PERNIX THERAPEUTICS HOLDINGS, INC.

ARTICLES OF AMENDMENT
 
 
                                    Pernix Therapeutics Holdings, Inc., a Maryland corporation (the “Corporation”), hereby certifies to the State Department of Assessments and Taxation (the “Department”) of Maryland that:

FIRST :  The charter of the Corporation as currently in effect (the “Charter”) is hereby amended by deleting therefrom in its entirety the first sentence of Section 1(a) of Article IV and inserting in lieu thereof a new sentence to read as follows:

The total number of shares of capital stock of all classes that the Corporation has authority to issue is One Hundred Fifty Million (150,000,000) shares of capital stock (par value one cent ($.01) per share), consisting of (i) One Hundred Forty Million (140,000,000) shares of common stock, par value one cent ($.01) per share (the “ Common Stock ”), and (ii) Ten Million (10,000,000) shares of preferred stock, par value one cent ($.01) per share (the “ Preferred Stock ”).  

SECOND :  The total number of shares of stock which the Corporation had authority to issue immediately prior to the foregoing amendment of the Charter was 100,000,000 shares of stock, consisting of 90,000,000 shares of Common Stock, $0.01 par value per share, and 10,000,000 shares of Preferred Stock, $0.01 par value per share, which includes 1,000,000 shares of Series B Junior Participating Stock.  The aggregate par value of all authorized shares of stock having par value was $1,000,000.

THIRD :  The total number of shares of stock which the Corporation has authority to issue pursuant to the foregoing amendment of the Charter is 150,000,000 shares of stock, consisting of 140,000,000 shares of Common Stock, $0.01 par value per share, and 10,000,000 shares of Preferred Stock, $0.01 par value per share, which includes 1,000,000 shares of Series B Junior Participating Stock.  The aggregate par value of all authorized shares of stock having par value is $1,500,000.

FOURTH :  The foregoing amendment of the Charter of the Corporation has been advised by the Board and approved by the stockholders of the Corporation.

FIFTH :  The information required by Section 2- 607(b)(2)(i) of the Maryland General Corporation Law was not changed by these Articles of Amendment.

SIXTH :  These Articles of Amendment shall become effective upon filing with the Department.

SEVENTH :  The undersigned acknowledges these Articles of Amendment to be the corporate act of the Corporation and as to all matters or facts required to be verified under oath, the undersigned acknowledges that, to the best of his knowledge, information and belief, these matters and facts are true in all material respects and that this statement is made under the penalties of perjury.
 
[The remainder of this page has been left blank intentionally.]
 
 
 

 
 
IN WITNESS WHEREOF, Pernix Therapeutics Holdings, Inc., has caused these Articles of Amendment to be signed in its name and on its behalf by its President and attested to by its Secretary on this 22nd day of July, 2015.
 
 
PERNIX THERAPEUTICS HOLDINGS, INC.
 
       
 
By:
 /s/ Douglas L. Drysdale
 
   
Name:  Douglas L. Drysdale
 
   
Title:    President
 
       

 
ATTEST:
 
 
       
 
By:
 /s/ Barry J. Siegel
 
   
Name:  Barry J. Siegel
 
   
Title:    Secretary
 
       

 


 

Exhibit 3.1

PERNIX THERAPEUTICS HOLDINGS, INC.

ARTICLES OF AMENDMENT
EFFECTING 1-for-10 REVERSE STOCK SPLIT

PERNIX THERAPEUTICS HOLDINGS, INC., a Maryland corporation having its principal office in Baltimore City , Maryland (the "Corporation"), hereby certifies to the Maryland State Department of Assessments and Taxation that:

FIRST: The charter of the Corporation is hereby amended by changing and reclassifying each of the shares of Common Stock (par value $0.01 per share) of the Corporation, which is issued and outstanding at the close of business on the effective date of this amendment, into one-tenth of a share of Common Stock (par value $0.01 per share) and by transferring from the common stock account to the additional paid-In capital account $0.01 with respect to each share which will no longer remain outstanding after this change and reclassification, such change, reclassification and combination to be made as a 1-for-10 reverse stock split.

SECOND: The directors of the Corporation, at a meeting duly noticed and held, adopted and approved the foregoing amendment by the vote required under Maryland law and the charter and bylaws of the Corporation. Pursuant to Section 2-309(e) of the Corporations and Associations Article of the Annotated Code of Maryland, stockholder approval of this charter amendment is not required.

THIRD: The Corporation has a class of equity securities registered under the Securities Exchange Act of 1934, as amended.

FOURTH: These Articles of Amendment and the reverse stock split effected hereby shall become effective at 4:01 pm on October 13, 2016.

FIFTH: The undersigned Chief Executive Officer acknowledges these Articles of Amendment to be the corporate act of the Corporation and, as to all matters or facts required to be verified under oath, the undersigned Chief Executive Officer acknowledges that to the best of his knowledge, information and belief, these matters and facts are true in all material respects and this statement is made under the penalties of perjury.

IN WITNESS WHEREOF, Pernix Therapeutics Holdings, Inc. has caused these presents to be signed in its name and on its behalf by its Chief Executive Officer this 13th day of October, 2016.

ATTEST:


/s/ Graham Miao                            
Secretary

PERNIX THERAPEUTICS HOLDINGS, INC.
 

By /s/ John A. Sedor                            
Chief Executive Officer

EXHIBIT 3.2

 
BYLAWS
 
OF
 
PERNIX THERAPEUTICS HOLDINGS, INC.
 
(in effect as of March 10, 2010)
 
 
 
 

 
  TABLE OF CONTENTS
 
ARTICLE I Offices       1  
         
Section 1.  Principal Office       1  
Section 2. Additional Offices       1  
Section 3.  Fiscal and Taxable Years       1  
         
ARTICLE II Definitions      1  
           
ARTICLE III Meetings of Stockholders 
     1  
           
Section 1.   Place      1  
Section 2.  Annual Meeting       1  
Section 3. Special Meetings       3  
Section 4.  Notice       3  
Section 5.  Organization       3  
Section 6. Quorum       3  
Section 7 Voting       3  
Section 8.  Proxies       3  
Section 9.  Voting of Shares by Certain Holders      4  
Section 10.  Inspectors       4  
Section 11. 
Determination of Stockholders of Record 
     4  
Section 12.  
Action Without a Meeting 
     5  
Section 13.  Voting by Ballot       5  
Section 14.  Control Share Acquisition Statute       5  
       
ARTICLE IV Directors      5  
         
Section 1. General Powers       5  
Section 2.   Number, Tenure and Qualifications       5  
Section 3.    Changes in Number; Vacancies       5  
Section 4.     Resignations      6  
Section 5.  Removal of Directors      6  
Section 6.    Annual and Regular Meetings       6  
Section 7.  Special Meetings      6  
Section 8.  
Notice 
     6  
Section 9.   Quorum       6  
Section 10. Voting       7  
Section 11.   Telephone Meetings      7  
Section 12.  
Action Without a Meeting 
     7  
Section 13. Compensation       7  
           
ARTICLE V Committees       7  
           
Section 1.    Committees of the Board       7  
Section 2.   Telephone Meetings       8  
Section 3.  Action By Committees Without a Meeting      8  
         
 ARTICLE VI Officers       8  
         
Section 1.   General Provisions       8  
Section 2.  Subordinate Officers, Committees and Agents       8  
Section 3.  Removal and Resignation       8  
Section 4. Vacancies       8  
Section 5. General Powers       8  
Section 6.  Chief Executive Officer       8  
 
 
 

 
 
Section 7.   Chief Operating Officer      9  
Section 8.  Chairman and Vice Chairman of the Board       9  
Section 9.  President       9  
Section 10.  Vice Presidents       9  
Section 11.  Secretary       9  
Section 12. Chief Financial Officer or Treasurer       9  
Section 13. Assistant Secretaries and Assistant Treasurers      9  
Section 14.  Salaries       10  
         
ARTICLE VII Contracts, Notes, Checks and Deposits       10  
         
Section 1.  Contracts       10  
Section 2. 
Checks and Drafts      10  
Section 3.  Deposits       10  
         
ARTICLE VIII Capital Shares       10  
         
Section 1.  Certificates of Shares      10  
Section 3.  Lost Certificate       10  
Section 4.  Transfer Agents and Registrars       10  
Section 5.   Transfer of Shares       11  
Section 6. Share Ledger       11  
         
ARTICLE IX Dividends       11  
         
Section 1. 
Declaration 
     11  
Section 2.  Contingencies      11  
         
ARTICLE X Indemnification and Limitation of Liability       11  
         
Section 1. Indemnification of Agents       11  
Section 2.  Insurance       11  
Section 3.   Indemnification Non-Exclusive       11  
Section 4.   Limitation of Liability       12  
         
 ARTICLE XI Seal       12  
         
Section 1.  Seal       12  
Section 2.  Affixing Seal       12  
         
ARTICLE XII Waiver of Notice       12  
         
ARTICLE XIII Amendment of Bylaws       12  
 
 
 

 
 
ARTICLE I
 
Offices
 
Section 1.    Principal Office .  The principal office of Pernix Therapeutics Holdings, Inc. (the “Corporation”) is located at 33219 Forest West Drive, Magnolia, Texas 77354, or at any other place as the Board may from time to time determine.
 
Section 2.    Additional Offices .  The Corporation may have additional offices at such places as the Board may from time to time determine or the business of the Corporation may require.
 
Section 3.    Fiscal and Taxable Years .  The fiscal and taxable years of the Corporation begin on January 1 and end on December 31.
 
ARTICLE II
 
Definitions
 
For purposes of these Bylaws, the following words have the meanings set forth below:
 
(a) An “Affiliate” of a person means (i) any person that, directly or indirectly, controls or is controlled by or is under common control with such person, (ii) any other person that owns, beneficially, directly or indirectly, 5% or more of the outstanding capital shares, shares or equity interests of such person, or (iii) any officer, director, employee, partner or trustee of such person or any person controlling, controlled by or under common control with such person (excluding trustees and persons serving in similar capacities who are not otherwise an Affiliate of such person).  The term “person” means and includes individuals, corporations, general and limited partnerships, limited liability companies, stock companies or associations, joint ventures, banks, trust companies, land trusts, business trusts, any other association, company, trust or entity or governments or the agencies or political subdivisions thereof.  For the purposes of this definition, “control” (including the correlative meanings of the terms “controlled by” and “under common control with”), as used with respect to any person, means the possession, directly or indirectly, of the power to direct or cause the direction of the management and policies of such person, through the ownership of voting securities, partnership interests or other equity interests.
 
(b) “Independent Director” means a director of the Corporation who is not an officer or employee of the Corporation or an Affiliate of (i) any advisor to the Corporation under an advisory agreement, (ii) any lessee of or management company operating any of the properties owned by the Corporation or any Affiliate of the Corporation, (iii) any subsidiary of the Corporation, or (iv) any partnership that is an Affiliate of the Corporation.
 
ARTICLE III
 
Meetings of Stockholders
 
Section 1.   Place .  All meetings of stockholders will be held at such place within the United States as may be stated in the notice.
 
Section 2.    Annual Meeting .
 
(a)  Date and Time .  The annual meeting of stockholders for the election of directors and the transaction of any other business as may be properly brought before the meeting will be held on such a day, in such a month and at such a time and place as may be designated by the Board.
 
(b)  Postponement .  The Board, acting by resolution, may postpone and reschedule any previously scheduled annual meeting of stockholders; provided , however that notice of the postponement of any properly-noticed annual meeting must be given, by any means specified in this Section 4 , not less than ten days prior to the previously scheduled meeting date.
 
 
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(c)   Effect of Failure to Hold Annual Meeting .  Failure to hold an annual meeting will not invalidate the Corporation’s existence or affect any otherwise valid corporate acts.
 
(d)   Transaction of Business.   Nominations of persons for election to the Board and the proposal of business to be considered by the stockholders may be made at an annual meeting of stockholders (i) pursuant to the Corporation’s notice of meeting, (ii) by or at the direction of the Board, or (iii) by any stockholder of the Corporation who was a stockholder of record at the time of giving of notice provided for herein, who is entitled to vote at the meeting and who complied with the notice procedures set forth herein.
 
(e)  Advance Notice Requirements.
 
(i) For nominations or other business to be properly brought before an annual meeting by a stockholder pursuant to clause (iii) of subsection (d)  of this Section 2 , the stockholder must have given timely notice thereof in writing delivered to the Secretary of the Corporation by personal delivery or by first-class United States mail, postage prepaid.  To be timely a stockholder’s notice must be delivered to the Secretary at the principal executive offices of the Company not less than 90 days nor more than 120 days prior to the first anniversary of the preceding year’s annual meeting; provided , however , that in the event that the date of the annual meeting is advanced by more than 30 days or delayed by more than 60 days from such anniversary date, notice by the stockholder to be timely must be so delivered not earlier than the 120th day prior to the actual annual meeting date and not later than the close of business on the later of the 90th day prior to the actual annual meeting date or the 20th day following the date on which public announcement of the date of such meeting is first made.  Such stockholder’s notice must set forth:
 
(1)     As to each person whom the stockholder proposes to nominate for election or reelection as a director, all information relating to such person that is required to be disclosed in solicitations of proxies for election of directors, or is otherwise required, in each case pursuant to Regulation 14A under the Securities Exchange Act of 1934, as amended (the “Exchange Act”), including such person’s written consent to being named in the proxy statement as a nominee and to serving as a director if elected;
   
(2)     As to any other business that the stockholder proposes to bring before the meeting, a brief description of the business desired to be brought before the meeting, the reasons for conducting such business at the meeting and any material interest in such business of such stockholder and the beneficial owner, if any, on whose behalf the proposal is made and a representation that the stockholder intends to appear in person or by proxy at the meeting to introduce such proposal; and
   
(3)     As to the stockholder giving the notice and the beneficial owner, if any, on whose behalf the nomination or proposal is made (i) the name and address of such stockholder, as they appear on the Corporation’s books, and of such beneficial owners, and (ii) the class and number of shares of the Corporation that are owned beneficially and of record by each stockholder and such beneficial owner.
 
(ii) With respect to stockholder nominations, only such persons who are nominated in accordance with the procedures set forth herein are eligible for election and to serve as directors.  With respect to stockholder proposals, only such business may be conducted at an annual meeting of stockholders as has been brought before the meeting in accordance with the procedures set forth herein.  The chairman of the meeting has the power and duty to determine whether a nomination or any business proposed to be brought before the meeting was made in accordance with the procedures set forth herein and, if any proposed nomination or business is not in such compliance, to declare that such defective proposal will be disregarded.
 
(f) Inclusion of Stockholder Proposals in Proxy Statement .  Notwithstanding the foregoing provisions, a stockholder must also comply with all applicable requirements of the Exchange Act and the rules and regulations thereunder with respect to the matters set forth herein.  Nothing herein will be deemed to affect any rights of stockholders to request inclusion of proposals in the Corporation’s proxy statement pursuant to Rule 14a-8 under the Exchange Act.  Any proposal that is properly included in the Corporation’s proxy statement and not validly withdrawn will be brought before the annual meeting.
 
 
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Section 3.    Special Meetings .
 
(a)  Calling of Special Meetings .  The President, a majority of the Board or a majority of the Independent Directors may call special meetings of the stockholders.  Special meetings of stockholders also may be called by the Secretary upon the written request of the holders of shares entitled to cast a majority (but not less than a majority) of all the votes entitled to be cast at such meeting.  Such request must state the purpose of such meeting and the matters proposed to be acted on at such meeting.  The Secretary will inform such stockholders of the reasonably estimated cost of preparing and mailing notice of the meeting and, upon payment to the Corporation of such costs by such stockholders, the Secretary will give notice to each stockholder entitled to notice of the meeting.  Unless requested by stockholders entitled to cast a majority of all the votes entitled to be cast at such meeting, a special meeting need not be called to consider any matter that is substantially the same as a matter voted on at any special meeting of the stockholders held during the preceding 12 months.  The Board has the sole power to fix the date, time and place of the special meeting, the record date for determining stockholders entitled to request a special meeting and the record date for determining stockholders entitled to notice of and to vote at the special meeting.
 
(b) Postponement.   The Board, acting by resolution, may postpone and reschedule any previously scheduled special meeting of stockholders; provided , however that notice of the postponement of any properly-noticed special meeting must be given by any means specified in this Section 4 , not less than ten days prior to the previously scheduled meeting date.
 
(c)  Transaction of Business.   Only such business may be conducted at a special meeting of stockholders as has been stated in the notice of meeting.  The chairman of the meeting has the power and duty to determine whether a nomination or any business proposed to be brought before the meeting was made in accordance with the procedures set forth herein and, if any proposed nomination or business is not in such compliance, to declare that such defective proposal be disregarded.
 
 
Section 4.   Notice .  Not less than ten nor more than 60 days before each meeting of stockholders, the Secretary must give to each stockholder entitled to vote at such meeting and to each stockholder not entitled to vote who is entitled to notice of the meeting, written or printed notice stating the time and place of the meeting and, in the case of a special meeting or as otherwise may be required by statute, the purpose for which the meeting is called, either by mail or by presenting it to such stockholder personally or by leaving it at his residence or usual place of business.  If mailed, such notice will be deemed given when deposited in the United States mail addressed to the stockholder at his post office address as it appears on the records of the Corporation, with postage thereon prepaid.
 
Section 5.   Organization .  At every meeting of the stockholders, the Chairman of the Board, if there be one, will conduct the meeting or, in the case of vacancy in office or absence of the Chairman of the Board, one of the following officers present will conduct the meeting in the order stated:  the Vice Chairman of the Board, if any, the President, if any, the Vice Presidents in their order of rank and seniority, if any, or a chairman chosen by the stockholders entitled to cast a majority of the votes, which all stockholders present in person or by proxy are entitled to cast, will act as chairman of the meeting, and the Secretary, or, in his absence, an assistant secretary or, in the absence of both the Secretary and assistant secretaries, a person appointed by the chairman of the meeting will act as secretary.
 
Section 6.    Quorum .  At any meeting of stockholders, the presence in person or by proxy of stockholders entitled to cast 50% of all the votes entitled to be cast at such meeting constitutes a quorum; but this Section 6 does not affect any requirement under any statute, the charter of the Corporation (the “Charter”) or these Bylaws for the vote necessary for the adoption of any measure.  If such quorum is not present at any meeting of the stockholders, the stockholders representing a majority of the shares entitled to vote at such meeting, present in person or by proxy, may vote to adjourn the meeting from time to time to a date not more than 120 days after the original record date without notice other than announcement at the meeting, until such quorum is present.  At such adjourned meeting at which a quorum is present, any business may be transacted that might have been transacted at the meeting as originally notified.
 
 
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Section 7.   Voting .  A plurality of all the votes cast at a meeting of stockholders duly called and at which a quorum is present is sufficient to elect a director.  There may be no cumulative voting.  Each common share may be voted for as many individuals as there are directors to be elected and for whose election the share is entitled to be voted.  A majority of the votes cast at a meeting of stockholders duly called and at which a quorum is present is sufficient to approve any other matter that may properly come before the meeting, unless more than a majority of the votes cast is required by statute, by the Charter or by these Bylaws.  Each stockholder of record has the right, at every meeting of stockholders, to one vote for each share held, except shares that are the subject of a redemption notice as provided in the Charter.
 
Section 8.   Proxies .  A stockholder may vote the common shares owned of record by him, either in person or by proxy executed or authorized by the stockholder, or by his duly authorized attorney in fact, in any manner permitted by law.  Such proxy must be filed with the Secretary of the Corporation before or at the time of the meeting.  No proxy will be valid after 11 months from the date of its execution, unless otherwise provided in the proxy.
 
Section 9.    Voting of Shares by Certain Holders .
 
(a) Shares registered in the name of a trust or another corporation, if entitled to be voted, may be voted by the president, a vice president or a proxy appointed by the president or a vice president of such trust or other corporation, unless some other person, who has been appointed to vote such shares pursuant to a bylaw or a resolution of the board of such trust or other corporation, presents a certified copy of such bylaw or resolution, in which case such person may vote such shares.  Any fiduciary may vote shares registered in his name as such fiduciary, either in person or by proxy.
 
(b) Shares indirectly owned by the Corporation may not be voted at any meeting and will not be counted in determining the total number of outstanding shares entitled to be voted at any given time, unless they are held by it in a fiduciary capacity, in which case they may be voted and must all be counted in determining the total number of outstanding shares at any given time.
 
(c) The Board may adopt by resolution a procedure by which a stockholder may certify in writing to the Corporation that any shares registered in the name of the stockholder are held for the account of a specified person other than the stockholder.  The resolution will set forth the class of stockholders who may make the certification, the purpose for which the certification may be made, the form of certification and the information to be contained in it, if the certification is with respect to a record date or closing of the share transfer books, the time after the record date or closing of the share transfer books within which the certification must be received by the Corporation and any other provisions with respect to the procedure that the Board considers necessary or desirable.  On receipt of such certification, the person specified in the certification will be regarded as, for the purposes set forth in the certification, the stockholder of record of the specified shares in place of the stockholder who makes the certification.
 
Section 10.    Inspectors .
 
(a) At any meeting of stockholders, the chairman of the meeting may, or upon the request of any stockholder must, appoint one or more persons as inspectors for such meeting.  Such inspectors will ascertain and report the number of shares represented at the meeting based upon their determination of the validity and effect of proxies, count all votes, report the results and perform such other acts as are proper to conduct the election and voting with impartiality and fairness to all the stockholders.
 
(b) Each report of an inspector must be in writing and signed by him or by a majority of them if there is more than one inspector acting at such meeting.  If there is more than one inspector, the report of a majority will be the report of the inspectors.  The report of the inspector or inspectors on the number of shares represented at the meeting and the results of the voting will be prima facie evidence thereof.
 
 
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Section 11.    Determination of Stockholders of Record .
 
(a) The Board will fix a date, not more than 60 nor less than ten days preceding the date of any meeting of stockholders, and not more than 60 days preceding the date fixed for the payment of any dividend or distribution, the date for the allotment of rights or the date when any change or conversion or exchange of shares will be made or go into effect, as a record date for the determination of the stockholders entitled to notice of, or to vote at, any such meeting, or entitled to receive any such dividend or distribution or allotment of rights, or to exercise the rights in respect to any such change, conversion or exchange of shares.
 
(b) When a determination of stockholders entitled to vote at any meeting of stockholders has been made as provided in subsection (a) of this Section 11 , such determination will apply to any adjournment thereof unless the meeting is adjourned to a date more than 120 days after the date fixed for the original meeting, in which case the Board will fix a new record date.
 
Section 12.    Action Without a Meeting .  Any action required or permitted to be taken at a meeting of stockholders may be taken without a meeting if a consent in writing, setting forth such action, is signed by each stockholder entitled to vote on the matter and any other stockholder entitled to notice of a meeting of stockholders (but not to vote thereat) has waived in writing any right to dissent from such action, and such consent and waiver are filed with the minutes of proceedings of the stockholders.
 
Section 13.   Voting by Ballot .  Voting on any question or in any election may be viva voce unless the chairman of the meeting orders or any stockholder demands that voting be by ballot.
 
Section 14.    Control Share Acquisition Statute .  Subtitle 7 of Title 3 of the Maryland General Corporation Law does not apply to any acquisition of shares of capital stock of the Corporation.
 
ARTICLE IV
 
Directors
 
Section 1.   General Powers .  The Board has full power to conduct, manage and direct the business and affairs of the Corporation, and all powers of the Corporation, except those specifically reserved or granted to the stockholders by statute or by the Charter or these Bylaws, will be exercised by, or under the authority of, the Board.
 
Section 2.    Number, Tenure and Qualifications .
 
(a) At any regular meeting or at any special meeting called for that purpose, a majority of the entire Board may establish, increase or decrease the number of directors, provided that the number thereof will not be less than the minimum number required by the General Laws of the State of Maryland now or hereafter in force, nor more than nine, and further provided that the tenure of office of a director will not be affected by any decrease in the number of directors.  The directors must be elected each year at the annual meeting of the stockholders.  Each director will continue in office for the term for which he is elected until his successor has been elected and qualified, or until his earlier death, resignation, retirement or removal in accordance with the Charter and these Bylaws.
 
(b) At all times, except during a period not to exceed 60 days following the death, resignation, incapacity or removal from office of a director prior to the expiration of the director’s term of office, a majority of the directors must be Independent Directors.
 
(c) Notwithstanding the foregoing requirement that a majority of the directors be Independent Directors, no action otherwise validly taken by the Board during a period in which a majority of its members are not Independent Directors will be invalidated or otherwise affected by such circumstance, nor will such circumstance subject the directors taking any such action to a higher standard of care or to liability other than that which would have applied to such action had a majority of the members of the Board been Independent Directors at the time such action was taken.
 
 
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Section 3.   Changes in Number; Vacancies .
 
(a) Any vacancy on the Board may be filled by the affirmative vote of the remaining directors, unless such vacancy resulted from an increase in the number of directors, in which case such vacancy may be filled by a majority of the entire Board; provided , however , that in the case of a vacancy resulting from the removal of a director by the stockholders pursuant to subsection (a) of this Section 5 , such vacancy may be filled in accordance with Article III , Section 7 .  Notwithstanding the foregoing, any vacancy on the Board among the directors elected by a class or series of equity shares (other than common shares), including any vacancy resulting from the removal of such director by the holders of such class or series of equity shares pursuant to subsection (b) of this Section 5 , may be filled by a majority of the remaining directors elected by that class or series, the sole remaining director elected by that class or series or by the stockholders by a majority of the votes of that class or series.  A director that fills a vacancy pursuant to subsection (a) of this Section 3 will continue in office until his successor has been elected and qualified, or until his earlier death, resignation, retirement or removal (in accordance with the Charter and these Bylaws).
 
(b) The Board may declare unqualified a director who has been declared of unsound mind by an order of court, who has pled guilty or nolo contendere to, or been convicted of, a felony involving moral turpitude or who has willfully violated the Charter or these Bylaws.  The office of a director declared unqualified will be considered vacant until filled as herein provided.
 
Section 4.   Resignations .  Any director or member of a committee may resign at any time.  Such resignation must be made in writing and will take effect at the time specified therein, or if no time be specified, at the time of the receipt by the Chairman of the Board, the President or the Secretary.
 
Section 5.    Removal of Directors .
 
(a) Any director may be removed, with or without cause, by the affirmative vote of the stockholders holding not less than two-thirds of all the votes entitled to be cast for the election of directors.
 
(b) Notwithstanding the provisions of subsection (a) of this Section 5 , in the case of any director elected by holders of a class or series of equity shares (other than common shares), such directors may be removed, with or without cause, by the affirmative vote of all of such class or series of equity shares.
 
Section 6.    Annual and Regular Meetings .  An annual meeting of the Board will be held immediately after and at the same place as the annual meeting of stockholders, and no notice of such meeting of the Board will be necessary.  The Board may provide, by resolution, the time and place, either within or without the State of South Carolina, for the holding of regular meetings of the Board without notice other than such resolution.
 
Section 7.   Special Meetings .  Special meetings of the Board may be called by or at the request of the President, a majority of the Board or a majority of the Independent Directors then in office.  The person or persons authorized to call special meetings of the Board may fix any place, either within or without the State of South Carolina, as the place for holding any special meeting of the Board called by them.
 
Section 8.   Notice .  Notice of any special meeting of the Board must be in writing and must be either (a) delivered by hand, (b) mailed by United States registered mail, return receipt requested, postage prepaid, (c) sent by a reputable, national overnight delivery service, or (d) sent by facsimile (with the original being sent by one of the other permitted means or by regular United States mail), and addressed to each director at his business or resident address.  Any such notice, request or other communication will be considered delivered on the date actually delivered or when delivery is refused or deemed impossible due to the recipient having changed its address without notifying the Company.  Notice given pursuant to subsections (a) and (d) must be given at least two days prior to the meeting.  Notice given pursuant to subsection (b) must be given at least five days prior to the meeting.  Notice given pursuant to subsection (c) must be given at least three days prior to the meeting.  Neither the business to be transacted at, nor the purpose of, any annual, regular or special meeting of the Board need be stated in the notice, unless required by statute or these Bylaws.
 
Section 9.    Quorum .
 
(a) A majority of the entire Board constitutes a quorum for transaction of business at any meeting of the Board, provided that, if less than a quorum is present at such meeting, a majority of the directors present may adjourn the meeting from time to time without further notice.
 
(b) The directors present at a meeting that has been duly called and convened may continue to transact business until adjournment, notwithstanding the withdrawal of enough directors to leave less than a majority of the entire Board, provided that at least one-third of the entire Board remains present at that meeting, in which case a quorum will still be deemed present.
 
 
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Section 10.   Voting .  The action of the majority of the directors present at a meeting at which a quorum is present will be the action of the Board, unless the concurrence of a greater proportion is required for such action by the Charter, these Bylaws or applicable statute.
  
Section 11.   Telephone Meetings .  Members of the Board may participate in a meeting by means of a conference telephone or similar communications equipment if all persons participating in the meeting can hear each other at the same time.  Participation in a meeting by these means constitutes presence in person at the meeting.
 
Section 12.   Action Without a Meeting .  Any action required or permitted to be taken at any meeting of the Board may be taken without a meeting if all members of the Board consent thereto in writing or by electronic transmission and the writing or writings or electronic transmission or transmissions are filed with the minutes of proceedings of the Board.
 
Section 13.    Compensation .  Independent Directors will receive such reasonable compensation for their services as directors as the Board may fix or determine from time to time; such compensation may include a fixed sum or capital shares of the Corporation and directors may receive reimbursement of reasonable expenses incurred in traveling to and from or attending regular or special meetings of the Board or of any committee thereof.
   
ARTICLE V
 
Committees
 
Section 1.    Committees of the Board .

(a)  The Board may appoint from among its members committees comprised of one or more directors.  The Board may delegate to any committee any of the powers of the Board except the power to elect directors, declare dividends or distributions on shares, recommend to the stockholders any action that requires stockholder approval, amend or repeal these Bylaws, approve any merger or share exchange that does not require stockholder approval or issue shares.  However, if the Board has given general authorization for the issuance of shares, a committee of the Board, in accordance with a general formula or method specified by the Board by resolution or by adoption of a share option plan, may fix the terms of shares, subject to classification or reclassification, and the terms on which any shares may be issued.
 
(b)  Notice of committee meetings must be given in the same manner as notice for special meetings of the Board.
 
(c)  At least one-third, but not less than two (unless the committee has less than two members), of the members of any committee must be present in person at any meeting of such committee in order to constitute a quorum for the transaction of business at such meeting, and the act of a majority present will be the act of such committee.  The Board may designate a chairman of any committee, and such chairman or any two members of any committee (unless the committee has less than two members, in which case one member of such committee) may fix the time and place of its meetings, unless the Board otherwise provides.  In the absence or disqualification of any member of any such committee, the members thereof present at any meeting and not disqualified from voting, whether or not they constitute a quorum, may unanimously appoint another director to act at the meeting in the place of such absent or disqualified members; provided , however , that in the event of the absence or disqualification of an Independent Director, such appointee will be an Independent Director.
 
(d)  Each committee will keep minutes of its proceedings and will report the same to the Board at the meeting next succeeding, and any action by the committees will be subject to revision and alteration by the Board, provided that no rights of third persons are affected by any such revision or alteration.
 
 
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(e)  Subject to the provisions hereof, the Board has the power at any time to change the membership of any committee, to fill all vacancies, to designate alternative members to replace any absent or disqualified members or to dissolve any such committee.
 
Section 2.    Telephone Meetings .  Members of a committee of the Board may participate in a meeting by means of a conference telephone or similar communications equipment if all persons participating in the meeting can hear each other at the same time.  Participation in a meeting by these means constitutes presence in person at the meeting.
 
Section 3.    Action By Committees Without a Meeting .  Any action required or permitted to be taken at any meeting of a committee of the Board may be taken without a meeting, if all members of the committee consent thereto in writing or by electronic transmission and the writing or writings or transmission or transmissions are filed with the minutes of proceedings of such committee.
 
ARTICLE VI
 
Officers
 
Section 1.    General Provisions .  The officers of the Corporation may consist of a Chairman of the Board, a Vice Chairman of the Board, a President, a Chief Executive Officer, a Chief Operating Officer, one or more Vice Presidents, a Chief Financial Officer or Treasurer, one or more assistant treasurers, a Secretary, one or more assistant secretaries and such other officers as may be pursuant to this Section 2 .  The officers of the Corporation will be appointed annually by the Board at the first meeting of the Board held after each annual meeting of stockholders.  If the appointment of officers is not held at such meeting, such election will be held as soon thereafter as may be convenient.  Each officer will hold office until his successor is appointed and qualified, or until his death, resignation, retirement or removal (in accordance with the Charter and these Bylaws).  Any two or more offices may be held by the same person.  In its discretion, the Board may leave unfilled any office except that of President and Secretary.  Appointment of an officer or agent does not of itself create contract rights between the Corporation and such officer or agent.
 
Section 2.    Subordinate Officers, Committees and Agents .  The Board may from time to time appoint such other officers and such committees, employees and other agents as the business of the Corporation may require, each of whom will hold office for such period, have such authority and perform such duties as are provided in these Bylaws, or as the Board may from time to time determine.  The directors may delegate to any officer or committee the power to elect subordinate officers and to retain or appoint employees or other agents.
 
Section 3.   Removal and Resignation .  Any officer or agent of the Corporation may be removed by the Board if in its judgment the best interests of the Corporation would be served thereby, but such removal will be without prejudice to the contract rights, if any, of the person so removed.  Any officer of the Corporation may resign at any time by giving written notice of his resignation to the Board, the Chairman of the Board, the President or the Secretary.  Any resignation will take effect at the time specified therein or, if the time when it becomes effective is not specified therein, immediately upon its receipt.  The acceptance of a resignation is not necessary to make it effective unless otherwise stated in the resignation.
 
Section 4.    Vacancies .  A vacancy in any office may be filled by the Board for the balance of the term.
 
Section 5.    General Powers .  All officers of the Corporation as between themselves and the Corporation will, respectively, have such authority and perform such duties in the management of the property and affairs of the Corporation as may be determined by resolution of the Board, or in the absence of controlling provisions in a resolution of the Board, as may be provided in these Bylaws.
 
Section 6.    Chief Executive Officer .  The Board may designate a Chief Executive Officer from among the elected officers.  The Chief Executive Officer will have responsibility for implementation of the policies of the Corporation, as determined by the Board, and for the administration of the business affairs of the Corporation.
 
 
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Section 7.   Chief Operating Officer .  The Board may designate a Chief Operating Officer from among the elected officers.  The Chief Operating Officer will have the responsibility and duties as set forth by the Board or the Chief Executive Officer.
 
Section 8.    Chairman and Vice Chairman of the Board .  The Chairman of the Board, if there be one, will preside over the meetings of the Board and of the stockholders at which he is present.  In the absence of the Chairman of the Board, the Vice Chairman of the Board, if any, will preside at such meetings at which he is present.  The Chairman of the Board and the Vice Chairman of the Board will, respectively, perform such other duties as may be assigned to him or them by the Board.
 
Section 9.     President .  The President will in general supervise and control all of the business and affairs of the Corporation.  Unless the President is not a member of the Board, in the absence of both the Chairman and Vice Chairman of the Board, he will preside at all meetings of the Board and of the stockholders at which he is present.  In the absence of a designation of a Chief Executive Officer by the Board, the President will be the Chief Executive Officer.  He may execute any deed, mortgage, bond, contract or other instrument to which the Corporation is a party, except in cases where the execution thereof is expressly delegated by the Board or by these Bylaws to some other officer or agent of the Corporation or is required by law to be otherwise executed.  The President will perform all duties incident to the office of President and such other duties as may be prescribed by the Board from time to time.
 
Section 10.   Vice Presidents .  In the absence of the President or in the event of a vacancy in such office, the Vice President (or in the event there be more than one Vice President, the Vice Presidents in the order designated at the time of their appointment or, in the absence of any designation, then in the order of appointment) will perform the duties of the President and when so acting will have all the powers of and be subject to all the restrictions upon the President, and will perform such other duties as from time to time may be assigned to him by the President or by the Board.  The Board may designate one or more Vice Presidents as executive Vice President or as Vice President for particular areas of responsibility.
 
Section 11.   Secretary .  The Secretary will (a) keep the minutes of the proceedings of the stockholders, the Board and committees of the Board in one or more books provided for that purpose, (b) see that all notices are duly given in accordance with the provisions of these Bylaws or as required by law, (c) be custodian of the corporate records and of the seal of the Corporation, (d) keep a register of the post office address of each stockholder that is furnished to the Secretary by such stockholder, (e) have general charge of the share transfer books of the Corporation, and (f) in general perform such other duties as from time to time may be assigned to him by the President or by the Board.
 
Section 12.    Chief Financial Officer or Treasurer .
 
(a) The Chief Financial Officer or Treasurer will have the custody of the corporate funds and securities and will deposit all monies and other valuable effects in the name and to the credit of the Corporation in such depositories as may be designated by the Board.
 
(b) He will disburse the funds of the Corporation as may be ordered by the Board, taking proper vouchers for such disbursements, and will render to the President and Board, at the regular meetings of the Board or whenever they may require it, an account of all his transactions as Chief Financial Officer or Treasurer and of the financial condition of the Corporation.
 
If required by the Board, he will give the Corporation a bond in such sum and with such surety or sureties as may be satisfactory to the Board for the faithful performance of the duties of his office and for the restoration to the Corporation, in case of his death, resignation, retirement or removal from office, all books, papers, vouchers, moneys and other property of whatever kind in his possession or under his control belonging to the Corporation.
 
 
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Section 13.   Assistant Secretaries and Assistant Treasurers .  The assistant secretaries and assistant treasurers, in general, will perform such duties as may be assigned to them by the Secretary or the Chief Financial Officer or Treasurer, respectively, or by the President or the Board.  The assistant treasurers will, if required by the Board, give bonds for the faithful performance of their duties in such sums and with such surety or sureties as may be satisfactory to the Board.
 
Section 14.    Salaries .  The salaries of the officers will be fixed from time to time by the Board and no officer will be prevented from receiving such salary by reason of the fact that he is also a director of the Corporation.
 
ARTICLE VII
 
Contracts, Notes, Checks and Deposits
 
Section 1.    Contracts .  The Board may authorize any officer or agent to enter into any contract or to execute and deliver any instrument in the name of and on behalf of the Corporation and such authority may be general or confined to specific instances.
 
Section 2.    Checks and Drafts .  All checks, drafts or other orders for the payment of money, notes or other evidences of indebtedness issued in the name of the Corporation will be signed by such officer or officers, agent or agents of the Corporation and in such manner as will from time to time be determined by the Board.
 
Section 3.    Deposits .  All funds of the Corporation not otherwise employed will be deposited from time to time to the credit of the Corporation in such banks, trust companies or other depositories as the Board may designate.
 
ARTICLE VIII
 
Capital Shares
 
Section 1.     Certificates of Shares .  Shares of the Corporation’s capital stock may be certificated or uncertificated, as provided under the Maryland General Corporation Law.  Owners of the Corporation’s capital stock will be recorded in the share transfer records of the Corporation and ownership of such shares will be evidenced by a certificate or book entry notation in the share transfer records of the Corporation.  Any certificates representing shares of the Corporation’s capital stock will be in such form as the Board prescribes and contain such information as may be required by the Maryland General Corporation Law or any securities exchanges on which any shares of the Corporation may be listed.  At the time of issue or transfer of shares without certificates, the Corporation, or an agent or representative thereof, will send to the registered owner thereof a written statement of the information required on certificates by the Maryland General Corporation Law.

Section 2.      Facsimile Signatures.   Any or all the signatures on certificates representing the capital stock of the Corporation may be facsimiles.  In case any officer who has signed or whose facsimile signature has been placed upon a certificate ceases to be such officer before such certificate is issued, it may be issued by the Corporation with the same effect as if he were such officer at the date of issue.
 
Section 3.     Lost Certificate .  The Board may direct a new certificate to be issued in place of any certificate previously issued by the Corporation alleged to have been lost, stolen or destroyed upon the making of an affidavit of that fact by the person claiming the certificate to be lost, stolen or destroyed.  When authorizing the issuance of a new certificate, the Board may, in its discretion and as a condition precedent to the issuance thereof, require the owner of such lost, stolen or destroyed certificate or his legal representative to advertise the same in such manner as it may require and/or to give bond, with sufficient surety, to the Corporation to indemnify it against any loss or claim that may arise as a result of the issuance of a new certificate.
 
Section 4.     Transfer Agents and Registrars .  At such time as the Corporation lists its securities on a national securities exchange or qualifies for trading in the over the counter market, the Board may appoint one or more banks or trust companies in such city or cities as the Board may deem advisable, from time to time, to act as transfer agents and/or registrars of the shares of the Corporation; and, upon such appointments being made, no certificate representing shares will be valid until countersigned by one of such transfer agents and registered by one of such registrars.
 
 
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Section 5.    Transfer of Shares .  Upon surrender to the Corporation or the transfer agent of a certificate for shares duly endorsed or accompanied by proper evidence of succession, assignment or authority to transfer, it will be the duty of the Corporation to issue a new certificate to the person entitled thereto, cancel the old certificate and record the transaction upon its books. Upon the receipt of proper transfer instructions from the registered owner of uncertificated shares, such uncertificated shares will be cancelled, issuance of new equivalent uncertificated shares or certificated shares will be made to the stockholder entitled thereto and the transaction will be recorded upon the books of the Corporation.
 
Section 6.    Share Ledger .  The Corporation will maintain at its principal office or at the office of its counsel, accountants or transfer agents an original or duplicate share ledger containing the name and address of each stockholder and the number of shares of each class held by such stockholder.
 
ARTICLE IX
 
Dividends
 
Section 1.    Declaration .  Dividends upon the shares of the Corporation may be declared by the Board, subject to applicable provisions of law and the Charter.  Dividends may be paid in cash, property or shares of the Corporation, subject to applicable provisions of law and the Charter.
 
Section 2.    Contingencies .  Before payment of any dividends, there may be set aside out of any funds of the Corporation available for dividends such sum or sums as the Board may from time to time, in its absolute discretion, think proper as a reserve fund for contingencies, for equalizing dividends, for repairing or maintaining the property of the Corporation, its subsidiaries or any partnership for which it serves as general partner or for such other purpose as the Board will determine to be in the best interest of the Corporation.  The Board may modify or abolish any such reserve in the manner in which it was created.
 
ARTICLE X
 
Indemnification and Limitation of Liability
 
Section 1.   Indemnification of Agents .  The Corporation will indemnify, in the manner and to the fullest extent permitted by law, any person (or the estate of any person) who is or was a party to, or is threatened to be made a party to, any threatened, pending or completed action, suit or proceeding, whether or not by or in the right of the Corporation, and whether civil, criminal, administrative, investigative or otherwise, by reason of the fact that such person is or was a director or officer of the Corporation, or such director or officer is or was serving at the request of the Corporation as a director, officer, agent or employee of another corporation, partnership, joint venture, trust or other enterprise.  To the fullest extent permitted by law, the indemnification provided herein includes expenses (including attorneys’ fees), judgments, fines and amounts paid in settlement and any such expenses may be paid by the Corporation in advance of the final disposition of such action, suit or proceeding.  The Corporation will indemnify other employees and agents to such extent as may be authorized by the Board or these Bylaws and as permitted by law.  Any repeal or modification of this Article X by the stockholders of the Corporation will be prospective only, and will not adversely affect any right to indemnification or advancement of expenses hereunder existing at the time of such repeal or modification.

Section 2.   Insurance .  The Corporation will to the fullest extent permitted by law, purchase and maintain insurance on behalf of any such person against any liability that may be asserted against such person.
 
Section 3.   Indemnification Non-Exclusive .  The indemnification provided herein is not deemed to limit the right of the Corporation to indemnify any other person for any such expenses to the fullest extent permitted by law, nor will it be deemed exclusive of any other rights to which any person seeking indemnification from the Corporation may be entitled under any agreement, vote of stockholders or disinterested directors, or otherwise, both as to action in such person’s official capacity and as to action in another capacity while holding such office.
 
 
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Section 4.    Limitation of Liability .  To the fullest extent permitted by Maryland statutory or decisional law, as amended or interpreted from time to time, no director or officer of the Corporation will be personally liable to the Corporation or its stockholders, or any of them, for money damages.  No amendment of these Bylaws or repeal of any of its provisions will limit or eliminate the benefits provided to directors and officers under this provision with respect to any act or omission that occurred prior to such amendment or repeal.
 
ARTICLE XI
 
Seal
 
Section 1.   Seal .  The Corporation may have a corporate seal, which may be altered at will by the Board.  The Board may authorize one or more duplicate or facsimile seals and provide for the custody thereof.  Unless specifically required by law, a corporate seal is not required for the due execution of any document.
 
Section 2.    Affixing Seal .  Whenever the Corporation is required to place its corporate seal to a document, it is sufficient to meet the requirements of any law, rule or regulation relating to a corporate seal to place the word “(SEAL)” adjacent to the signature of the person authorized to execute the document on behalf of the Corporation.
 
ARTICLE XII
 
Waiver of Notice
 
Whenever any notice is required to be given pursuant to the Charter or these Bylaws of the Corporation or pursuant to applicable law, a waiver thereof in writing, signed by the person or persons entitled to such notice, whether before or after the time stated therein, is deemed equivalent to the giving of such notice.  Neither the business to be transacted at, nor the purpose of any meeting, need be set forth in the waiver of notice, unless specifically required by statute.  The attendance of any person at any meeting for the express purpose of objecting to the transaction of any business on the ground that the meeting is not lawfully called or convened will not be considered a waiver of notice.
 
ARTICLE XIII
 
Amendment of Bylaws
 
The Board will have the exclusive power to adopt, alter or repeal any Bylaws of the Corporation and to make new Bylaws, provided that any amendment to Section 2 or Section 3 of Article III , or any amendment to Section 2 , Section 3 , Section 5 or Section 9 of Article IV requires the affirmative vote of 80% of the entire Board.
 
 
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Exhibit 3.2

First Amendment to the Bylaws of Pernix Therapeutics Holdings, Inc.

October 13, 2016

On October 13, 2016, the Board of Directors (the "Board") of Pernix Therapeutics Holdings, Inc. (the "Corporation"), in accordance with the Corporation's Bylaws (the "Bylaws") and the Maryland General Corporation Law, approved and adopted the following amendment to the Bylaws, to be effective immediately:

  1. Article III, Section 7 of the Bylaws is hereby amended and restated in its entirety to read as follows:

Section 7. Voting .

(a)

Except for the election of directors, a majority of the votes cast at a meeting of stockholders duly called and at which a quorum is present is sufficient to approve any matter that may properly come before the meeting, unless more than a majority of the votes cast is required by statute, by the Charter or by these Bylaws. Each stockholder of record has the right, at every meeting of stockholders, to one vote for each share held, except shares that are the subject of a redemption notice as provided in the Charter.

(b)

There may be no cumulative voting with respect to the election of directors. Each common share may be voted for as many individuals as there are directors to be elected and for whose election the share is entitled to be voted. At all meetings of stockholders for the election of directors, each director shall be elected by a majority of the votes cast by the shares present in person or represented by proxy at the meeting and entitled to vote on the election of directors; provided that, if the election is contested, the directors shall be elected by a plurality of the votes cast by the shares present in person or represented by proxy at the meeting and entitled to vote on the election of directors. An election shall be contested if, as determined by the Board, the number of nominees for director exceeds the number of directors to be elected. A majority of votes cast shall mean that the number of votes cast "for" a director's election exceeds the number of votes cast "against" that director's election by the shares present in person or represented by proxy at the meeting and entitled to vote on the election of directors (with "abstentions" and "broker non-votes" not counted as a vote cast either "for" or "against" that director's election). In an uncontested election, if a nominee for director who is a director at the time of election does not receive the vote of at least the majority of the votes cast at any meeting for the election of directors at which a quorum is present, the director shall promptly tender his or her resignation to the Board. The Nominating Committee of the Board (the "Nominating Committee") (or a similar committee) will make a recommendation to the Board as to whether to accept or reject the tendered resignation, or whether other action should be taken. The Board will act on the tendered resignation, taking into account the Nominating Committee's (or similar committee's) recommendation, and publicly disclose (by a press release, a filing with the Securities and Exchange Commission or other broadly disseminated means of communication) its decision regarding the tendered resignation within 90 days from the date of the certification of the election results. The Nominating Committee (or similar committee) in making its recommendation, and the Board in making its decision, may each consider any factors or other information that it considers appropriate and relevant. The director who tenders his or her resignation will not participate in the recommendation of the Nominating Committee (or similar committee) or the decision of the Board with respect to his or her resignation. If a director's resignation is not accepted by the Board, such director will continue to serve until his or her successor is duly elected and qualified, or until his or her earlier death, resignation, retirement or removal in accordance with the Charter and these Bylaws. If a director's resignation is accepted by the Board pursuant to this Bylaw, or if a nominee for director is not elected and the nominee is not an incumbent director, then the Board, in its sole discretion, may fill any resulting vacancy pursuant Article IV, Section 3 of these Bylaws or may decrease the size of the Board pursuant to the provisions of Article IV, Section 2 of these Bylaws.

July 26, 2016        

Barry Siegel
747 Clarendon Road
Penn Valley, PA 19072

Re: Resignation and Release Agreement

Dear Barry:

This Resignation and Release Agreement ("Agreement") sets forth our agreement concerning your resignation of employment with Pernix Therapeutics Holdings, Inc. ("Pernix" or the "Company") and contains the terms of your separation. PLEASE READ THIS AGREEMENT CAREFULLLY. BY SIGNING THIS AGREEMENT, YOU ARE RELINQUISHING AND WAIVING IMPORTANT LEGAL RIGHTS. AS EXPLAINED IN THIS AGREEMENT, YOU HAVE TWENTY-ONE (21) CALENDAR DAYS TO REVIEW THIS AGREEMENT, ARE URGED TO REVIEW IT WITH COUNSEL OF YOUR CHOICE, AND HAVE SEVEN (7) CALENDAR DAYS TO REVOKE THIS AGREEMENT AFTER YOU SIGN IT ("REVOCATION PERIOD"), AFTER WHICH THE OBLIGATIONS BECOME FINAL AND BINDING.

Based on the foregoing, and in consideration of the covenants and promises contained herein and other good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, you and Pernix agree as follows:

1. Pernix has accepted your voluntary resignation without Good Reason (as defined in that certain offer letter dated May 8, 2014 between you and Pernix, as amended) effective July 26, 2016 (the "Separation Date").

2. If you sign this Agreement and do not revoke it during the Revocation Period, Pernix shall continue to pay you your regular base salary ($344,792 annually, paid in installments according to the Company's payroll practices), less all applicable taxes and withholdings, for six (6) months from the Separation Date ("Severance Payments").

3. Provided that you execute and deliver this Agreement in a timely manner and do not exercise your right to revoke it, and are currently enrolled in Pernix medical, dental and/or vision plans, and if you elect continuation of group health coverage through ADP COBRA following your Separation Date, Pernix shall for a period of up to six (6) months continue to contribute the same percentage of the premium amount as Pernix contributed for you and your dependents when were actively employed, effective the first of the month following your Separation Date. You will be responsible to pay the remaining amount due.

4. You represent, warrant and acknowledge that you have been paid and/or received all compensation, wages, bonuses, commissions, vacation and/or benefits to which you may be entitled and that no other compensation, wages, bonuses, commissions, expense reimbursement and/or benefits are due to you, except as provided herein.


5. (a) In exchange for Pernix providing you with the Severance Payments and COBRA as set forth in Section 3 , you, your heirs and your personal representatives hereby IRREVOCABLY AND UNCONDITIONALLY RELEASE AND WAIVE ALL CLAIMS against Pernix, including its present or former subsidiaries, parents, divisions, affiliates, successors, assigns, and each of their representatives, agents, administrators, fiduciaries, shareholders, members, officers, directors, attorneys and employees (collectively, including Pernix, the "Releasees"), and release and discharge the Releasees, or any one of them, from liability for any claims or damages you may have against it or them as of the date of this Agreement, whether known or unknown, including, but not limited to, any alleged violation of the Age Discrimination in Employment Act, as amended; the Older Workers Benefit Protection Act; Title VII of the Civil Rights of 1964, as amended; Sections 1981 through 1988 of Title 42 of the United States Code; the Civil Rights Act of 1991; the Equal Pay Act; the Americans with Disabilities Act; the Rehabilitation Act; the Family Medical Leave Act; the Employee Retirement Income Security Act of 1974, as amended; the Worker Adjustment and Retraining Notification Act; the National Labor Relations Act; the Fair Credit Reporting Act; the Occupational Safety and Health Act; the Uniformed Services Employment and Reemployment Act; the Employee Polygraph Protection Act; the Immigration Reform Control Act; the Genetic Information Nondiscrimination Act of 2008; the New Jersey Law Against Discrimination; the New Jersey Domestic Partnership Act; the New Jersey Civil Union Act; the New Jersey Conscientious Employee Protection Act; the New Jersey Family Leave Act; the New Jersey Wage and Hour Law; the New Jersey Equal Pay Law; the New Jersey Occupational Safety and Health Law; the New Jersey False Claims Act; the New Jersey Smokers' Rights Law; the New Jersey Genetic Privacy Act; the New Jersey Fair Credit Reporting Act; the New Jersey Millville Dallas Airmotive Plant Job Loss Notification Act; the retaliation provisions of the New Jersey Workers' Compensation Law; the Pennsylvania Human Relations Act; the Pennsylvania Whistleblower Law; the Pennsylvania Public Employee Relations Act; and any personal gain with respect to any claim arising under the Federal False Claims Act (and including any and all amendments to the above) and/or any other alleged violation of any federal, state, local, or other law, regulation or ordinance, and/or contract or implied contract or tort law or common law or public policy or whistleblower claim, having any relation whatsoever to your employment by and the termination of your employment with Pernix or any Releasee including, but not limited to, any claim for wrongful or constructive discharge; back pay; vacation pay; sick pay; wage, commission or bonus payments; equity grants; attorneys' fees; costs, and/or loss of future wages.

You understand and acknowledge that this Release is intended to be as broad as legally permissible and applies to both employment-related and non-employment- related claims up to the date you execute this Agreement. This paragraph does not release or waive any claims or rights that, as a matter of law, cannot be waived.

(b) You represent and warrant that you have no knowledge of any work-related injury or illness incurred while working for Pernix, that you have not filed a claim or an application for benefits under any workers' compensation law, that you do not have any such claim, and that you do not intend to make a workers' compensation claim or file an application for workers' compensation benefits.

(c) You represent and warrant that the Severance Payments and COBRA set forth in Section 3 are sufficient consideration for the release of claims in this Section 5 .


6. You agree that by entering into this Agreement, Pernix and the Releasees do not admit any violation of law and specifically deny committing any such violation.

7. To the extent permitted by law, you represent and warrant that you are not aware of any proceeding that is pending before any court, administrative agency, governmental authority, regulatory agency or other regulatory authority that is based on, refers to, relates to or arises out of any claims or disagreement you may have had against, or believe you have had, with respect to your employment with Pernix or matters related thereto. If you have already filed a charge or claim with any federal, state or local agency, you are not required to dismiss that charge or claim to be eligible for the additional consideration offered by Pernix. You nonetheless warrant and represent, to the maximum extent permitted by law, that you have not filed any complaint, charge or proceeding of any type with any court, administrative agency, governmental authority, quasi-governmental authority or otherwise, based on, referring to or arising out of any occurrence or event that predates the execution of this Agreement and/or relating to your employment with any Releasee and/or the conclusion of that employment; provided, however, that nothing in this Agreement will prevent you from filing any action to enforce this Agreement. Furthermore, nothing in the Agreement shall affect your right to file a charge or complaint with the Equal Employment Opportunity Commission or the National Labor Relations Board or to participate or cooperate in such a matter; provided, however, that you agree and acknowledge that you are not entitled to, and explicitly relinquish and waive any claim or entitlement to, any monetary or personal recovery or benefit in connection with any charge or proceeding involving you. Should any judicial, regulatory or administrative complaint, investigation, charge, action or proceeding be brought against any Releasee on your behalf, or should any effort be made to include you as a party in any pending complaint, charge, investigation, action or proceeding, you agree that you will, at Pernix's expense, take all steps necessary and lawful to opt out, abandon and disclaim interest in such complaint, charge, action, investigation or proceeding. Further, you agree that you will not testify, assist or participate (except in response to judicial, regulatory or administrative order or subpoena, court order or other legal process or as otherwise required, and not merely permitted, by law) in any lawsuit, administrative action, or any judicial, regulatory or administrative proceeding or investigation brought against any Releasee. Pernix agrees that in the event you are called to testify in any proceeding with regard to any events during your employment with Pernix, Pernix will furnish you with counsel of Pernix's choice and reasonably acceptable to you, at Pernix's expense. The parties agree that certain matters in which you have been involved during your employment may necessitate your cooperation with Pernix in the future. Accordingly, you shall cooperate with Pernix in connection with matters arising out of your service to the Company, including internal investigations. Pernix shall reimburse you for reasonable expenses incurred and a reasonable daily rate agreed upon by the parties in connection with such cooperation (for the sake of clarity, Pernix will not be required to reimburse you for expenses incurred or pay you a reasonable daily rate if you are subpoenaed to testify on behalf of a party other than Pernix). You agree that, to the extent permitted by law, you will promptly notify Pernix if (i) you learn that a complaint, charge, action, investigation or proceeding has been filed against any Releasee, or (ii) you receive a notice or subpoena to testify, assist or participate in any lawsuit, administrative action, or any judicial, regulatory or administrative proceeding or investigation brought against any Releasee. You shall be covered by any Company insurance policies and procedures in effect from time to time that apply to former employees in the position that you held with the Company.

8. You acknowledge that prior to the Separation Date, you disclosed to Pernix to the best of your knowledge, in accordance with applicable policies and procedures, any and all information relevant to any investigation of Pernix business practices conducted by any government agency, and/or relevant to any existing litigation involving Pernix, whether administrative, civil or criminal in nature, and you are unaware of any allegations of fraud or criminal acts relating to current or former employees of the Company that have not been disclosed to the Company.


9. You further represent and warrant that in your capacity as an employee of Pernix, you are not aware of any reason to believe that Pernix or any of its affiliated companies and their respective officers, directors, agents or employees had taken or failed to take any action in any way directly or indirectly connected with its sales, marketing and billing operations, or otherwise that would cause it to be in violation of any Medicare, Medicaid or any other reimbursement program, or third-party-payer or other contract based upon or related to the products and/or services provided. You further represent and warrant that in your capacity as an employee of Pernix, you are not aware of any reason to believe that Pernix or any of its affiliated companies and their respective officers, directors, agents or employees had taken or failed to take any action in any way directly or indirectly connected with its sales, marketing and billing operations that would cause it to be in violation of any applicable federal, state, local or other law.

10. You acknowledge that, during your employment with Pernix, you acquired certain confidential, proprietary and trade secret information regarding the Releasees including, without limitation, non-public patient lists and information relating to the sources of patients, financial, personnel, and patient information, and other non-public confidential information concerning the business and affairs of suppliers, creditors, lenders, shareholders and patients of Pernix and its affiliates, as well as confidential information protected by HIPAA ("Confidential Information"). You acknowledge that you have not retained any written or other tangible material concerning any Confidential Information, whether located on your own personal computer or elsewhere. You agree to keep strictly confidential and not disclose any Confidential Information. You understand and acknowledge that your obligations under this Agreement with regard to any particular Confidential Information commenced upon the Separation Date and shall continue hereafter until such time as such Confidential Information has become public knowledge other than as a result of your breach of this Agreement or breach by those acting with you or on your behalf.

11. You agree to return promptly all Pernix property including, without limitation, all access passes, cell phones, personal digital assistants (PDAs), keys, laptops computers, credit cards, hardware, software, files, papers, memoranda, letters, handbooks, manuals, computer generated reports, patient lists and other tools or products of your employment (including copies) whether prepared by you or others.

12. For a period of one (1) year commencing on your Separation Date (the "Restricted Period"), you agree to not directly or indirectly, in any capacity, solicit for hire, attempt to hire, encourage or recommend for hire, or hire or employ, or conspire with, or aid or abet any third party in the solicitation, hiring or employment, of, any individual who is a Pernix employee, agent, consultant, or representative at the time of your separation from Pernix or was so employed at any time within one (1) year of your Separation Date. In the event of a violation of this Section 12 , the length of the Restricted Period shall be extended by an amount of time equal to the period of time during which a violation of this Section 12 is deemed by a court of competent jurisdiction to have occurred (including any period required for litigation during which Pernix seeks to enforce such covenant).

13. You agree that you will not publicly or privately disparage Releasees or any of Pernix's officers, employees or affiliates, or the products, services, business, operations, personnel policies or procedures of any of them by any means, including, but not limited to, via the Internet or other media. Pernix will not disparage you or your performance by any means, including, but not limited to, via the Internet or other media.


14. You will have up to twenty-one (21) calendar days from the date you receive this Agreement to consider its terms and return it to Human Resources at Pernix. You acknowledge that if you fail to provide Pernix with the executed Agreement by the close of business on the twenty-first (21st) calendar day, this Agreement will be null and void.

15. During this twenty-one (21) calendar day period and before signing below, you are advised to consult with an attorney regarding the terms of this Agreement, at your own expense. The terms of the offer set forth herein will expire at the conclusion of the twenty-first (21st) calendar day period, if not accepted during that period of time. You may sign the Agreement prior to the conclusion of the twenty-first (21st) calendar day period. If you elect to do so, you acknowledge that you have done so voluntarily. Your signature below indicates that you are entering into this Agreement freely, knowingly and voluntarily, with a full understanding of its terms. You also acknowledge that you will have seven (7) calendar days from the date you sign this Agreement to revoke the Agreement by notifying the undersigned, at Pernix, in writing prior to the expiration of the seven (7) calendar day period.

16. (a) This Agreement constitutes and contains our complete understanding with respect to the subject matter addressed in this Agreement and supersedes and replaces all prior negotiations, agreements and representations, if any, whether written or oral, concerning the subject matter of this Agreement, except for the Confidentiality and Non-Competition Agreement executed by the parties on August 14, 2015; provided, however, as of the Separation Date Sections IV and V of such Agreement shall terminate and be of no further force and effect. The parties have executed this Agreement with full knowledge of any and all rights they may have, and they hereby assume the risk of any mistake of fact in connection with the true facts involved, or with regard to any facts that are now unknown to them.

(b) If any provision of the Agreement is held to be illegal, void, or unenforceable, such provision shall be of no force or effect. The illegality or unenforceability of such provision, however, shall have no effect upon, and shall not impair the legality or enforceability of, any other provision of this Agreement. Upon any finding by a court of competent jurisdiction that a release or waiver of claims or rights or a covenant provided for herein is illegal, void, or unenforceable, you agree, upon Pernix's request, promptly to execute a release, waiver, and/or covenant satisfactory to the Releasees that is legal and enforceable to the fullest extent legally permitted.

17. (a) Any controversy or dispute arising out of or relating to this Agreement, arising out of or relating to any aspect of the relationship between us, or to the interpretation of this Agreement, shall be settled exclusively by arbitration conducted in New Jersey, unless otherwise mutually agreed upon, before a single arbitrator in accordance with the employment arbitration rules of the American Arbitration Association ("AAA") then in effect and with discovery permitted by both parties in accordance with such rules. The award of the arbitrator shall be final and binding, and judgment may be entered on the arbitrator's award in any court having jurisdiction. In addition to any other relief awarded to the prevailing party in any such arbitration, the non-prevailing party in any such arbitration shall be obligated to pay any attorney's fees and costs incurred by the prevailing party in such action. This arbitration provision does not preclude you from bringing issues to the attention of federal, state, or local agencies. Such agencies can, if the law allows, seek relief against us on your behalf. The arbitrator may award declaratory or injunctive relief only in favor of the individual party seeking relief and only to the extent necessary to provide relief warranted by that party's individual claim. You and Pernix agree that each may bring claims against the other only in your or its individual capacity, and not as a plaintiff or class member in any purported class or representative proceeding. You agree that by entering into this Agreement, you and Pernix are each waiving the right to a trial by jury or to participate in a class action.


(b) This Agreement shall be construed and enforced in accordance with, and governed by, the laws of the State of New Jersey, without regard to conflict of laws principles. If any clause of this Agreement should ever be determined to be unenforceable, it is agreed that this will not affect the enforceability of any other clause or the remainder of this Agreement.

(c) This Agreement may be entered into any arbitral (or other necessary) proceeding to prove that a settlement was reached and to establish the material terms thereof, so long as application is first made to file it under seal.

(d) No waiver by either of the parties of any breach by the other party of any condition or provision of this Agreement to be performed by the other party shall be deemed a waiver of any similar or dissimilar provision or condition at the same or any prior or subsequent time.

18. By signing this Agreement, you acknowledge that: (1) you have read this Agreement completely; (2) you have had an opportunity to consider the terms of this Agreement for at least twenty-one (21) calendar days and understand you have seven (7) calendar days to revoke your agreement after you sign it; (3) you have been advised to consult with an attorney of your choice to explain the Agreement and its consequences; (4) you know that you are giving up important legal rights by signing this Agreement, including releasing both known and unknown claims; (5) you have not relied on any representation or statement that is not set forth in this Agreement; (6) you understand and intend everything that you have agreed to in this Agreement, and you agree to all of its terms; and (7) you have signed this Agreement voluntarily and entirely of your own free will.

UNDERSTOOD, AGREED AND ACCEPTED:

 

 

Pernix Therapeutics Holdings, Inc.:

 

 

 

 

 

John A. Sedor

Barry Siegel

 

Executed by (print name):

 

 

 

/s/ Barry Siegel

 

/s/ John A. Sedor

Sugnature

 

Sugnature

 

 

 

July 26, 2016

 

July 26, 2016

Date

 

Date

EXHIBIT 31.1

CERTIFICATION

I, John Sedor, certify that:

1. I have reviewed this Quarterly Report on Form 10-Q of Pernix Therapeutics Holdings, Inc.;

2. Based on my knowledge, this quarterly report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this report;

3. Based on my knowledge, the financial statements, and other financial information included in this quarterly report, fairly present in all material respects the financial condition, results of operations and cash flows of the Registrant as of, and for, the periods presented in this quarterly report;

4. The Registrant's other certifying officer and I are responsible for establishing and maintaining disclosure controls and procedures (as defined in Exchange Act Rules 13a-15(e) and 15d-15(e)) and internal control over financial reporting (as defined in Exchange Act Rules 13a-15(f) and 15d-15(f)) for the Registrant and have:

(a) Designed such disclosure controls and procedures, or caused such disclosure controls and procedures to be designed under our supervision, to ensure that material information relating to the Registrant, including its consolidated subsidiaries, is made known to us by others within those entities, particularly during the period in which this quarterly report is being prepared;

(b) Designed such internal control over financial reporting, or caused such internal control over financial reporting to be designed under our supervision, to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external purposes in accordance with generally accepted accounting principles;

(c) Evaluated the effectiveness of the Registrant's disclosure controls and procedures and presented in this quarterly report our conclusions about the effectiveness of the disclosure controls and procedures, as of the end of the period covered by this report based on such evaluation; and

(d) Disclosed in this report any change in the Registrant's internal control over financial reporting that occurred during the Registrant's most recent fiscal quarter (the Registrant's fourth fiscal quarter in the case of an Annual Report) that has materially affected, or is reasonably likely to materially affect, the Registrant's internal control over financial reporting; and

5. The Registrant's other certifying officer and I have disclosed, based on our most recent evaluation of internal control over financial reporting, to the Registrant's auditors and the audit committee of the Registrant's board of directors (or persons performing the equivalent functions):

(a) All significant deficiencies and material weaknesses in the design or operation of internal control over financial reporting which are reasonably likely to adversely affect the Registrant's ability to record, process, summarize and report financial information; and

(b) Any fraud, whether or not material, that involves management or other employees who have a significant role in the Registrant's internal control over financial reporting.

 

 

 

 

November 10, 2016

 

/s/ JOHN SEDOR

 

 

 

John Sedor

 

 

 

Chairman and Chief Executive Officer
(Principal Executive Officer)

 

 


EXHIBIT 31.2

CERTIFICATION

I, Graham Miao, certify that:

1. I have reviewed this Quarterly Report on Form 10-Q of Pernix Therapeutics Holdings, Inc.;

2. Based on my knowledge, this quarterly report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this quarterly report;

3. Based on my knowledge, the financial statements, and other financial information included in this quarterly report, fairly present in all material respects the financial condition, results of operations and cash flows of the Registrant as of, and for, the periods presented in this quarterly report;

4. The Registrant's other certifying officer and I are responsible for establishing and maintaining disclosure controls and procedures (as defined in Exchange Act Rules 13a-15(e) and 15d-15(e)) and internal control over financial reporting (as defined in Exchange Act Rules 13a-15(f) and 15d-15(f)) for the Registrant and have:

(a) Designed such disclosure controls and procedures, or caused such disclosure controls and procedures to be designed under our supervision, to ensure that material information relating to the Registrant, including its consolidated subsidiaries, is made known to us by others within those entities, particularly during the period in which this quarterly report is being prepared;

(b) Designed such internal control over financial reporting, or caused such internal control over financial reporting to be designed under our supervision, to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external purposes in accordance with generally accepted accounting principles;

(c) Evaluated the effectiveness of the Registrant's disclosure controls and procedures and presented in this quarterly report our conclusions about the effectiveness of the disclosure controls and procedures, as of the end of the period covered by this quarterly report based on such evaluation; and

(d) Disclosed in this quarterly report any change in the Registrant's internal control over financial reporting that occurred during the Registrant's most recent fiscal quarter (the Registrant's fourth fiscal quarter in the case of an Annual Report) that has materially affected, or is reasonably likely to materially affect, the Registrant's internal control over financial reporting; and

5. The Registrant's other certifying officer and I have disclosed, based on our most recent evaluation of internal control over financial reporting, to the Registrant's auditors and the audit committee of the Registrant's board of directors (or persons performing the equivalent functions):

(a) All significant deficiencies and material weaknesses in the design or operation of internal control over financial reporting which are reasonably likely to adversely affect the Registrant's ability to record, process, summarize and report financial information; and

(b) Any fraud, whether or not material, that involves management or other employees who have a significant role in the Registrant's internal control over financial reporting.

November 10, 2016

 

/s/ GRAHAM MIAO

 

 

 

Graham Miao

 

 

 

President and Chief Financial Officer
(Principal Financial Officer)

 

 


EXHIBIT 32.1

CERTIFICATION UNDER SECTION 906
OF THE SARBANES-OXLEY ACT OF 2002

Pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002, each of the undersigned certifies that this periodic report fully complies with the requirements of section 13(a) or 15(d) of the Securities Exchange Act of 1934, as amended; and that information contained in this periodic report fairly presents, in all material respects, the financial condition and results of operations of Pernix Therapeutics Holdings, Inc. for the periods covered by this periodic report.

Date: November 10, 2016

 

/s/ JOHN SEDOR

 

 

 

John Sedor

 

 

 

Chairman and Chief Executive Officer
(Principal Executive Officer)

 

 

 

 

 

Date: November 10, 2016

 

/s/ GRAHAM MIAO

 

 

 

Graham Miao
President and Chief Financial Officer

 

 

 

(Principal Financial Officer)