UNITED
	STATES
	SECURITIES
	AND EXCHANGE COMMISSION
	WASHINGTON,
	D.C. 20549
	 
	FORM
	8-K
	 
	CURRENT
	REPORT
	 
	Pursuant
	to Section 13 or 15(d) of the Securities Exchange Act of 1934
	 
	Date
	of Report (Date of earliest event reported):   July 1,
	2010
	 
	ENTREMED,
	INC.
	(Exact
	Name of Registrant as Specified in its Charter)
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	DELAWARE
 
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	0-20713
 
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	58-1959440
 
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	(State
	or other jurisdiction of
 
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	(Commission
	File Number)
 
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	(IRS
	Employer Identification
 
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	incorporation
	or organization)
 
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	No.)
 
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	9640
	Medical Center Drive
	Rockville,
	Maryland
	(Address
	of principal executive offices)
	 
	20850
	 
	(Zip
	Code)
	 
	(240)
	864-2600
	(Registrant’s
	telephone number, including area code)
	 
	Not
	Applicable
	(Former
	name or former address, if changed since last report)
	 
	Check the
	appropriate box below if the Form 8-K filing is intended to simultaneously
	satisfy the filing obligation of the
	registrant
	under any of the following provisions:
	 
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	¨
 
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	Written
	communications pursuant to Rule 425 under the Securities Act (17 CFR
	230.425)
 
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	¨
 
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	Soliciting
	material pursuant to Rule 14a-12 under the Exchange Act (17 CFR
	240.14a-12)
 
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	¨
 
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	Pre-commencement
	communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR
	240.14d-2(b))
 
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	¨
 
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	Pre-commencement
	communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR
	240.13e-4(c))
 
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	Item
	5.03.     Amendments to Articles of Incorporation or
	Bylaws; Change in Fiscal Year.
	On June
	30, 2010, EntreMed, Inc. (the “Company”) filed a Certificate of Amendment of
	Amended and Restated Certificate of Incorporation ( the “Amendment”) with the
	Delaware Secretary of State to amend the Company’s Amended and Restated
	Certificate of Incorporation.  The Amendment, which was effective as
	of 8:00 a.m. EST, on July 1, 2010 (the “Effective Time”), affected a 1-for-11
	reverse stock split of the Company’s common stock, $0.01 par value per share
	(“Common Stock”).
	As a
	result of the reverse stock split, each eleven shares of the Common Stock that
	were issued and outstanding or held in treasury at the Effective Time were
	automatically combined into one share.  No fractional shares will be
	issued in connection with the reverse stock split. Stockholders who are entitled
	to fractional shares will receive a cash payment in lieu of receiving fractional
	shares equal to the fractional share interest multiplied by $0.40 (the per share
	closing price of the Company’s common stock as last reported on the Nasdaq Stock
	Market on June 30, 2010).
	For the
	purpose of identifying the reverse stock split, the Company's trading symbol
	will be temporarily changed from “ENMD” to “ENMDD” for a period of twenty
	trading days beginning July 1, 2010.  The Company's trading symbol
	will revert to “ENMD” on July 30, 2010.   The Company’s new CUSIP
	number for its Common Stock is 29382F  202.
	The
	Company’s transfer agent and exchange agent for purposes of the reverse stock
	split, American Stock Transfer & Trust Company, LLC, will send instructions
	to stockholders of record who hold stock certificates regarding the exchange of
	old stock certificates for new stock certificates.
	The
	Amendment is attached hereto as Exhibit 3.1 and is incorporated by reference
	herein.  The press release announcing the reverse stock split is attached
	hereto as Exhibit 99.1 and is incorporated by reference herein.
	 
	Item
	9.01    Financial Statements and Exhibits.
	 
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	3.1
 
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	Certificate of Amendment of
	Amended and Restated Certificate of
	Incorporation
 
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	99.1
 
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	Press Release, dated June 30,
	2010
 
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	SIGNATURES
	 
	Pursuant
	to the requirements of the Securities Exchange Act of 1934, the registrant has
	duly caused this report to be signed on its behalf by the undersigned hereunto
	duly authorized.
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	ENTREMED,
	INC.
 
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	/s/ Cynthia W. Hu
 
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	Cynthia
	W. Hu
 
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	Chief
	Operating Officer, General Counsel &
	Secretary
 
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	Date:  July
	7, 2010
	Exhibit
	Index
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	3.1
 
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	Certificate of Amendment of
	Amended and Restated Certificate of
	Incorporation
 
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	99.1
 
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	Press Release, dated June 30,
	2010
 
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	Exhibit
	3.1
	CERTIFICATE
	OF AMENDMENT
	OF
	AMENDED
	AND RESTATED CERTIFICATE OF INCORPORATION
	OF
	ENTREMED, INC.
	 
	EntreMed, Inc. (the
	“Corporation”), a corporation organized and existing under the General
	Corporation Law of the State of Delaware, does hereby certify:
	 
	 FIRST: That the Board of
	Directors of the Corporation has duly adopted resolutions: (i) authorizing
	the Corporation to execute and file with the Secretary of State of the State of
	Delaware this Certificate of Amendment of Amended and Restated Certificate of
	Incorporation (this “Certificate of Amendment”) to combine each eleven (11)
	outstanding shares of the Corporation's common stock, par value $0.01 per share
	(the “Common Stock”), into one (1) share of Common Stock, par value $0.01
	per share; and (ii) declaring this Certificate of Amendment to be advisable
	and recommended for approval by the stockholders of the
	Corporation.
	 
	SECOND: That this Certificate of
	Amendment was duly adopted in accordance with the provisions of Section 242
	of the General Corporation Law of the State of Delaware by the Board of
	Directors and the stockholders of the Corporation.
	 
	THIRD: That the capital of the
	Corporation shall not be reduced under or by reason of this Certificate of
	Amendment.
	 
	FOURTH: That upon the effectiveness of
	this Certificate of Amendment, Article FOURTH of the Amended and Restated
	Certificate of Incorporation is hereby amended and restated such that, as
	amended, said paragraph below shall read as follows:
	 
	“The total number of shares of capital
	stock which the Corporation is authorized to issue is One Hundred Seventy Five
	Million (175,000,000) divided into two classes as follows:
	(A)  
	Common Stock
	. One
	Hundred Seventy Million (170,000,000) shares of common stock, $.01 par value per
	share (“Common Stock”), the holder of which shall be entitled to one vote for
	each share on all matters required or permitted to be voted on by stockholders
	of the Corporation, and
	(B) 
	Preferred
	Stock
	. Five Million (5,000,000) shares of preferred stock, $1.00 par
	value per share (“Preferred Stock”).
	 
	Effective
	at 8:00 a.m. on July 1, 2010, each eleven (11) shares of Common Stock issued and
	outstanding at such time shall be combined into one (1) share of Common
	Stock (the “Reverse Stock Split”).  No fractional shares shall be
	issued upon the Reverse Stock Split.  All shares of Common Stock
	(including fractions thereof) issuable upon the Reverse Stock Split to a given
	holder shall be aggregated for purposes of determining whether the Reverse Stock
	Split would result in the issuance of any fractional share.  If, after
	the aforementioned aggregation, the Reverse Stock Split would result in the
	issuance of a fraction of a share of Common Stock, the Corporation shall, in
	lieu of issuing any such fractional share, pay the holder otherwise entitled to
	such fraction a sum in cash equal to the fraction multiplied by the fair market
	value per share of the Common Stock as determined in a reasonable manner by the
	Board of Directors.  Upon surrender by a holder of a certificate or
	certificates for Common Stock (including, for this purpose, a holder of shares
	of Common Stock issuable upon conversion of Preferred Stock), duly endorsed, at
	the office of the Corporation (or, if lost, an acceptable affidavit of loss is
	delivered to the Corporation), the Corporation shall, as soon as practicable
	thereafter, issue and deliver to such holder, or to the nominee or assignee of
	such holder, a new certificate or certificates for the number of shares of
	Common Stock, or book-entry shares in lieu of a new certificate or certificates
	evidencing and representing the number of shares of Common Stock, that such
	holder shall be entitled to following the Reverse Stock Split.”
	 
	FIFTH:    This
	Certificate of Amendment shall become effective at 8:00 a.m. on July 1,
	2010.
	 
	IN WITNESS WHEREOF, the Corporation has
	caused this Certificate of Amendment of Amended and Restated Certificate of
	Incorporation to be executed by Cynthia W. Hu, its Chief Operating Officer,
	General Counsel and Secretary, this 30
	th
	day
	of June, 2010.
	 
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	ENTREMED,
	INC.
 
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	By:
 
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	/s/ Cynthia W. Hu
 
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	Name:   
 
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	Cynthia
	W. Hu
 
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	Title:
 
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	Chief
	Operating Officer, General Counsel &
 
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	Secretary
 
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	Exhibit
	99.1
	 
	 
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	FOR
	IMMEDIATE RELEASE:
 
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	CONTACT:
 
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	June
	30, 2010
 
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	Ginny
	Dunn
 
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	4:15
	p.m. EDT
 
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	Associate
	Director, Corporate
 
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	Communications
	& Investor
 
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	Relations
 
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	EntreMed,
	Inc.
 
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	240.864.2643
 
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	ENTREMED
	ANNOUNCES REVERSE STOCK SPLIT
	ROCKVILLE, MD
	, June 30, 2010 –
	EntreMed, Inc. (Nasdaq: ENMD), today announced that it has filed a certificate
	of amendment to its Amended and Restated Certificate of Incorporation to effect
	a 1-for-11 reverse stock split that will become effective with the open of
	trading on July 1, 2010.   The primary objective in affecting a
	reverse split is to better enable the Company to maintain the listing of its
	common stock on the NASDAQ Capital Market.  The Company’s common stock
	will continue trading on the NASDAQ Capital Market and will begin trading on a
	split-adjusted basis at the open of trading on Thursday, July 1,
	2010.
	At EntreMed’s Annual Meeting of
	Stockholder’s held on June 3, 2010, stockholders voted to approve a proposal
	authorizing the Board of Directors, at its discretion, to implement a reverse
	split at a ratio between 1-for-2 and 1-for-20 of the Company’s common stock
	without further action from stockholders, and as authorized, the Board of
	Directors has elected to effect a reverse split at the ratio of
	1-for-11.
	 “We appreciate the support of our
	stockholders in granting our Board of Directors the authority to affect a
	reverse split.  After in-depth consideration of our options, the Board
	determined that a reverse split of the Company’s stock is in the best interest
	of stockholders and is the appropriate next step in order to execute our
	clinical development objectives for ENMD-2076,” commented Michael M. Tarnow,
	Executive Chairman of EntreMed.  “By affecting a reverse stock split,
	the Company is better positioned to regain compliance with the NASDAQ listing
	rules.  Maintaining our listing on NASDAQ provides the Company with
	greater flexibility with respect to access to the capital markets.  We
	feel positive about the clinical results of ENMD-2076 thus far and maintaining
	our listing on NASDAQ affords us greater corporate opportunities to continue to
	financially and strategically support the development of
	ENMD-2076.”
	Details
	of the Reverse Split
	At the effective time of the reverse
	stock split, every 11 shares of EntreMed’s pre-split common stock, par value,
	$0.01 per share, will automatically be reclassified as and converted into 1
	share of post-split common stock, par value, $0.01 per share.  As a
	result of the reverse split, the number of shares of outstanding common stock
	will be approximately 9.5 million, excluding stock options and unexercised
	warrants and subject to adjustment for fractional shares.  The reverse
	stock split will not affect any stockholder’s ownership percentage of EntreMed’s
	shares, except to the limited extent that the reverse stock split would result
	in any stockholder owning a fractional share.
 
	It is expected that NASDAQ will append
	a “D” to the Company’s ticker symbol to indicate the completion of the reverse
	split and that after a 20 trading-day period following the reverse split, the
	ticker symbol will revert to “ENMD”.  In addition, shares of EntreMed
	common stock will also trade under a new CUSIP number effective July 1,
	2010.
	Additional information, including FAQ’s
	from our shareholders, can be accessed directly at
	www.entremed.com/Reverse-Split-FAQs.pdf
	and in the Company’s definitive proxy statement filed with the SEC on April 29,
	2010.
	About
	EntreMed
	EntreMed, Inc. is a clinical-stage
	pharmaceutical company committed to developing ENMD-2076, a selective angiogenic
	kinase inhibitor, for the treatment of cancer.  ENMD-2076 is currently
	in a multi-center Phase 2 study in ovarian cancer and in several Phase 1 studies
	in solid tumors, multiple myeloma, and leukemia.  Additional
	information about EntreMed is available on the Company’s web site at
	www.entremed.com
	and
	in various filings with the Securities and Exchange Commission.
	 
	Forward
	Looking Statements
	 
	This release contains forward-looking
	statements within the meaning of the Private Securities Litigation Reform Act
	with respect to the outlook for expectations for future financial or business
	performance, strategies, expectations and goals. Forward-looking statements are
	subject to numerous assumptions, risks and uncertainties, which change over
	time.  Forward-looking statements speak only as of the date they are made,
	and no duty to update forward-looking statements is assumed. Actual results
	could differ materially from those currently anticipated due to a number of
	factors, including those set forth in Securities and Exchange Commission filings
	under "Risk Factors," including  the risk that we may be unable to continue
	as a going concern as a result of our inability to raise sufficient capital for
	our operational needs; the possibility that we may be delisted from trading on
	the Nasdaq Capital Market; the volatility of our common stock; risks relating to
	the need for additional capital and the uncertainty of securing additional
	funding on favorable terms; the failure to consummate a transaction to monetize
	the royalty stream for any reason, including our inability to obtain the
	required third-party consents; declines in actual sales of Thalomid
	®
	resulting in reduced revenues; risks associated with the Company’s
	product candidates; the early-stage products under development; results in
	preclinical models are not necessarily indicative of clinical results;
	uncertainties relating to preclinical and clinical trials, including delays to
	the commencement of such trials; success in the clinical development of any
	products; dependence on third parties; future capital needs; and risks relating
	to the commercialization, if any, of the Company's proposed products (such as
	marketing, safety, regulatory, patent, product liability, supply, competition
	and other risks).
	 
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