Exhibit 1.1
ANCHIANO THERAPEUTICS LTD.
2,652,174 American Depositary Shares
Representing
13,260,870 Ordinary Shares
UNDERWRITING AGREEMENT
February 12, 2019
Oppenheimer & Co. Inc.
85 Broad Street
New York, New York 10004
as Representative of the several
Underwriters named in Schedule I hereto
Ladies and Gentlemen:
Anchiano Therapeutics Ltd.,
a company organized under the laws of the State of Israel (the “Company”), proposes, subject to the terms and conditions
contained herein, to sell to you and the other underwriters (the “Underwriters”) named on Schedule I to this Underwriting
Agreement (the “Agreement”), for whom you are acting as Representative (the “Representative”), an aggregate
of 2,652,174 American Depositary Shares (the “Firm Shares”), representing an aggregate of 13,260,870 ordinary shares,
no par value per share, of the Company (the “Ordinary Shares”) (“ADSs” shall mean the American Depositary
Shares of the Company, each ADS representing five (5) Ordinary Shares). The respective amounts of the Firm Shares to be purchased
by each of the several Underwriters are set forth opposite their names on Schedule I hereto. In addition, the Company proposes
to grant to the Underwriters an option to purchase up to an additional 397,826 ADSs (representing 1,989,130 Ordinary Shares, in
the aggregate) (the “Option Shares”) from the Company for the purpose of covering over-allotments in connection with
the sale of the Firm Shares. The ADSs purchased by the Underwriters will be evidenced by American Depositary Receipts (“ADRs”)
to be issued pursuant to a Deposit Agreement dated on or about the date hereof (the “Deposit Agreement”) entered into
by and among the Company, The Bank of New York Mellon, as depository of the Company (the “Depository”), and all owners
and beneficial owners from time to time of the ADSs. The Firm Shares and the Option Shares are collectively called the “Shares.”
The Company has prepared
and filed in conformity with the requirements of the Securities Act of 1933, as amended (the “Securities Act”), and
the published rules and regulations thereunder (the “Rules”) adopted by the Securities and Exchange Commission (the
“Commission”), a registration statement on Form F-6 (No. 333-229522) covering the registration of the ADSs under the
Securities Act (the “ADS Registration Statement”), a Registration Statement (as hereinafter defined) on Form F-1 (No.
333-229155), including a preliminary prospectus, and such amendments thereof as may have been required to the date of this Agreement.
Copies of such Registration Statement (including all amendments thereof) and of the related Preliminary Prospectus (as hereinafter
defined) have heretofore been delivered by the Company to you. The term “Preliminary Prospectus” means any preliminary
prospectus included at any time as a part of the Registration Statement or filed with the Commission by the Company pursuant to
Rule 424(a) of the Rules. The term “Registration Statement” as used in this Agreement means the initial registration
statement (including all exhibits and financial schedules), as amended at the time and on the date it becomes effective (the “Effective
Date”), including the information (if any) contained in the form of final prospectus filed with the Commission pursuant to
Rule 424(b) of the Rules and deemed to be part thereof at the time of effectiveness pursuant to Rule 430A of the Rules. If the
Company has filed an abbreviated registration statement to register additional Shares pursuant to Rule 462(b) under the Rules (the
“462(b) Registration Statement”), then any reference herein to the Registration Statement shall also be deemed to include
such 462(b) Registration Statement. The term “Prospectus” as used in this Agreement means the prospectus in the form
included in the Registration Statement at the time of effectiveness or, if Rule 430A of the Rules is relied on, the term Prospectus
shall also include the final prospectus filed with the Commission pursuant to and within the time limits described in Rule 424(b)
of the Rules.
The Company understands that
the Underwriters propose to make a public offering of the Shares, as set forth in and pursuant to the Statutory Prospectus (as
hereinafter defined) and the Prospectus, as soon after the Effective Date and the date of this Agreement as the Representative
deems advisable. The Company hereby confirms that the Underwriters and dealers have been authorized to distribute or cause to be
distributed each Preliminary Prospectus, and each Issuer Free Writing Prospectus (as hereinafter defined) and are authorized to
distribute the Prospectus (as from time to time amended or supplemented if the Company furnishes amendments or supplements thereto
to the Underwriters).
1.
Sale,
Purchase, Delivery and Payment for the Shares
. On the basis of the representations, warranties and agreements contained in,
and subject to the terms and conditions of, this Agreement:
(a) The
Company agrees to issue and sell to each of the Underwriters, and each of the Underwriters agrees, severally and not jointly, to
purchase from the Company, at a purchase price of $10.695 per ADS (the “ADS Price”), the number of Firm Shares set
forth opposite the name of such Underwriter under the column “Number of Firm Shares to be Purchased” on Schedule I
to this Agreement, subject to adjustment in accordance with Section 8 hereof.
(b) The
Company hereby grants to the several Underwriters an option to purchase, severally and not jointly, all or any part of the Option
Shares at the ADS Price. The number of Option Shares to be purchased by each Underwriter shall be the same percentage (adjusted
by the Representative to eliminate fractions) of the total number of Option Shares to be purchased by the Underwriters as such
Underwriter is purchasing of the Firm Shares. Such option may be exercised only to cover over-allotments in the sales of the Firm
Shares by the Underwriters and may be exercised in whole or in part at any time on or before 12:00 noon, New York City time, on
the business day before the Firm Shares Closing Date (as defined below), and from time to time thereafter within 30 days after
the date of this Agreement, in each case upon written notice, or verbal or telephonic notice confirmed by written notice, by the
Representative to the Company no later than 12:00 noon, New York City time, on the business day before the Firm Shares Closing
Date or at least two business days before the Option Shares Closing Date (as defined below), as the case may be, setting forth
the number of Option Shares to be purchased and the time and date (if other than the Firm Shares Closing Date) of such purchase.
(c) Payment
of the purchase price for, and delivery of certificates for, the Firm Shares shall be made at the offices of Oppenheimer &
Co. Inc., 85 Broad Street, New York, New York 10004, at 10:00 a.m., New York City time, on the second business day following the
date of this Agreement or at such time on such other date, not later than ten (10) business days after the date of this Agreement,
as shall be agreed upon by the Company and the Representative (such time and date of delivery and payment are called the “Firm
Shares Closing Date”). In addition, in the event that any or all of the Option Shares are purchased by the Underwriters,
payment of the purchase price, and delivery of the certificates, for such Option Shares shall be made at the above-mentioned offices,
or at such other place as shall be agreed upon by the Representative and the Company, on each date of delivery as specified in
the notice from the Representative to the Company (such time and date of delivery and payment are called the “Option Shares
Closing Date”). The Firm Shares Closing Date and any Option Shares Closing Date are called, individually, a “Closing
Date” and, together, the “Closing Dates.”
(d) Payment
shall be made to the Company by wire transfer of immediately available funds against delivery of the respective certificates to
the Representative for the respective accounts of the Underwriters of certificates for the Shares to be purchased by them.
(e) The
Shares shall be registered in such names and shall be in such denominations as the Representative shall request at least two full
business days before the Firm Shares Closing Date or, in the case of Option Shares, on the day of notice of exercise of the option
as described in Section 1(b), and shall be delivered by or on behalf of the Company to the Representative through the facilities
of The Depository Trust Company (“DTC”) for the account of each Underwriter named in Schedule I hereto.
2.
Representations
and Warranties of the Company
. The Company represents and warrants to each Underwriter as of the date hereof, as of the Firm
Shares Closing Date and as of each Option Shares Closing Date (if any), as follows:
(a) On
the Effective Date, the Registration Statement complied, and, on the date it became effective, the ADS Registration Statement complied,
and on the date of the Prospectus, the date any post-effective amendment to the Registration Statement or the ADS Registration
Statement becomes effective, the date any supplement or amendment to the Prospectus is filed with the Commission and each Closing
Date, the Registration Statement, the Prospectus (and any amendment thereof or supplement thereto) and the ADS Registration Statement
(and any amendment thereof or supplement thereto) will comply, in all material respects, with the requirements of the Securities
Act and the Rules and the Securities and Exchange Act of 1934, as amended (the “Exchange Act”) and the rules and regulations
of the Commission thereunder. Neither the Registration Statement nor the ADS Registration Statement, nor any amendments of either
of the foregoing, as of the times they became effective, contained any untrue statement of a material fact or omit to state any
material fact required to be stated therein or necessary in order to make the statements therein not misleading; and on the Effective
Date and the other dates referred to above neither the Registration Statement, the ADS Registration Statement nor the Prospectus,
nor any amendment or supplement of either of the foregoing, will contain any untrue statement of a material fact or will omit to
state any material fact required to be stated therein or necessary in order to make the statements therein not misleading. When
any Preliminary Prospectus was first filed with the Commission (whether filed as part of the Registration Statement or any amendment
thereto or pursuant to Rule 424(a) of the Rules) and when any amendment thereof or supplement thereto was first filed with the
Commission, such Preliminary Prospectus as amended or supplemented complied in all material respects with the applicable provisions
of the Securities Act and the Rules and did not contain an untrue statement of a material fact or omit to state a material fact
necessary to make the statements therein, in the light of the circumstances under which they were made, not misleading. If applicable,
each Preliminary Prospectus and the Prospectus delivered to the Underwriters for use in connection with this offering was identical
to the electronically transmitted copies thereof filed with the Commission pursuant to EDGAR, except to the extent permitted by
Regulation S-T. Notwithstanding the foregoing, none of the representations and warranties in this Section 2(a) shall apply to statements
in, or omissions from, the Registration Statement, any Preliminary Prospectus or the Prospectus made in reliance upon, and in conformity
with, information herein or otherwise furnished in writing by the Representative on behalf of the several Underwriters specifically
for use in the Registration Statement, any Preliminary Prospectus or the Prospectus, as the case may be. With respect to the preceding
sentence, the Company acknowledges that the only information furnished in writing by the Representative on behalf of the several
Underwriters for use in the Registration Statement, any Preliminary Prospectus or the Prospectus is the statements contained in
the 3
rd
and 12
th
paragraphs under the caption “Underwriting” in the Prospectus (collectively,
the “Underwriter Information”).
(b) As
of the Applicable Time (as hereinafter defined), none of (i) the price to the public and the number of Shares sold, as indicated
on the cover page of the Prospectus and the Statutory Prospectus (as hereinafter defined), considered together (collectively, the
“General Disclosure Package”), (ii) any individual Issuer Free Writing Prospectus when considered together with
the General Disclosure Package, (iii) any individual Written Testing-the Waters Communication (as defined herein), and (iv) the
ADS Registration Statement or any amendments or supplements thereto, when considered together with the General Disclosure Package,
included, includes or will include an untrue statement of a material fact or omitted, omits or will omit to state a material fact
necessary to make the statements therein, in the light of the circumstances under which they were made, not misleading; provided,
however, that this representation and warranty shall not apply to statements in or omissions in the General Disclosure Package
made in reliance upon and in conformity with the Underwriter Information.
Each Issuer Free Writing
Prospectus (as hereinafter defined) (i) is identified in Schedule III hereto and (ii) complied when issued, and complies,
in all material respects with the requirements of the Securities Act and the Rules. The Company has made at least one version of
a road show, as defined in Rule 433 under the Securities Act (a “Road Show”), available without restriction by means
of graphic communication to any person, including any potential investor in the Shares (and if there is more than one version of
a Road Show for the offering that is a written communication, the version available without restriction was made available no later
than the other versions).
As used in this Section and elsewhere
in this Agreement:
“Applicable
Time” means 8:15 a.m. (New York City time) on the date hereof.
“Statutory
Prospectus” as of any time means the Preliminary Prospectus relating to the Shares that is included in the Registration Statement
immediately prior to the Applicable Time.
“Issuer Free
Writing Prospectus” means each “free writing prospectus” (as defined in Rule 433 of the Rules) relating
to the Shares.
(c) The
Registration Statement and the ADS Registration Statement are effective under the Securities Act and no stop order preventing or
suspending the effectiveness of the Registration Statement or the ADS Registration Statement or suspending or preventing the use
of any Preliminary Prospectus, the Prospectus or any “issuer free writing prospectus,” as defined in Rule 433
under the Rules, has been issued by the Commission and no proceedings for that purpose have been instituted or, to the Company’s
knowledge, are threatened under the Securities Act. Any required filing of any Preliminary Prospectus and/or the Prospectus and
any supplement thereto pursuant to Rule 424(b) of the Rules has been or will be made in the manner and within the time period required
by such Rule 424(b). Any material required to be filed by the Company pursuant to Rule 433(d) or Rule 163(b)(2) of the Rules has
been or will be made in the manner and within the time period required by such Rules.
(d) Each
Issuer Free Writing Prospectus listed in Schedule III hereto, when taken together with the General Disclosure Package, did not,
as of the Applicable Time, contain an untrue statement of a material fact or omit to state a material fact necessary to make the
statements therein, in the light of the circumstances under which they were made, not misleading, provided that no representation
or warranty is made as to information contained or omitted from any Issuer Free Writing Prospectus in reliance upon and in conformity
with written information furnished to the Company through the Representative by or on behalf of any Underwriter specifically for
inclusion therein.
If at any time following
issuance of an Issuer Free Writing Prospectus there occurred or occurs an event or development as a result of which such Issuer
Free Writing Prospectus conflicted or would conflict with the information contained in the Registration Statement, the Statutory
Prospectus or the Prospectus or included or would include an untrue statement of a material fact or omitted or would omit to state
a material fact required to be stated therein or necessary in order to make the statements therein, in the light of the circumstances
prevailing at the subsequent time, not misleading, the Company has promptly notified or will promptly notify the Representative
and has promptly amended or will promptly amend or supplement, at its own expense, such Issuer Free Writing Prospectus to eliminate
or correct such conflict, untrue statement or omission.
(e) The financial statements
of the Company (including all notes and schedules thereto) included in the Registration Statement, the Statutory Prospectus and
the Prospectus present fairly in all material respects the financial position of the Company and its consolidated subsidiaries
at the dates indicated and the statement of operations, shareholders’ equity and cash flows of the Company and its consolidated
subsidiaries for the periods specified; and such financial statements and related schedules and notes thereto, and the unaudited
financial information filed with the Commission as part of the Registration Statement, have been prepared in conformity with International
Financial Reporting Standards (“IFRS”) as adopted by International Accounting Standards Board, consistently applied
throughout the periods involved. The summary and selected financial data included in the Statutory Prospectus and Prospectus present
fairly the information shown therein as at the respective dates and for the respective periods specified. The Registration Statement,
the Statutory Prospectus, and the Prospectus do not include any pro forma financial statements.
(f) Somekh
Chaikin, a member firm of KPMG International (the “Auditor”), whose reports are filed with the Commission as a part
of the Registration Statement, are and, to the knowledge of the Company, during the periods covered by their reports, were independent
public accountants as required by the Securities Act and the Rules.
(g) The
Company and each of its subsidiaries, including each entity (corporation, partnership, joint venture, association or other business
organization) controlled directly or indirectly by the Company (each, a “subsidiary”), is duly organized, validly existing
and (where such concept is applicable) in good standing under the laws of their respective jurisdictions of incorporation or organization,
except where the failure to be in good standing could not in the aggregate reasonably be expected to have a material adverse effect
on the assets, properties, condition, financial or otherwise, or in the results of operations, business affairs or business prospects
of the Company and its subsidiaries considered as a whole (a “Material Adverse Effect”). Each such entity has all requisite
power and authority to carry on its business as is currently being conducted as described in the Statutory Prospectus and the Prospectus,
and to own, lease and operate its properties.
All of the issued shares
of capital stock of, or other ownership interests in, each subsidiary have been duly and validly authorized and issued and are
fully paid and non-assessable and are owned, directly or indirectly, by the Company, free and clear of any lien, charge, mortgage,
pledge, security interest, claim, limitation on voting rights, equity, trust or other encumbrance, preferential arrangement, defect
or restriction of any kind whatsoever. The Company and each of its subsidiaries is duly qualified to do business and (where such
concept is applicable) is in good standing as a foreign corporation in each jurisdiction in which the nature of the business conducted
by it or location of the assets or properties owned, leased or licensed by it requires such qualification, except for such jurisdictions
where the failure to so qualify, individually or in the aggregate, would not reasonably be expected to have a Material Adverse
Effect; and, to the Company’s knowledge, no proceeding has been instituted in any such jurisdiction revoking, limiting or
curtailing, or seeking to revoke, limit or curtail, such power and authority or qualification.
(h) (i)
At the time of filing the Registration Statement and (ii) on the date hereof
,
the Company was not and is not an “ineligible
issuer,” as defined in Rule 405 of the Rules.
(i) The
Company and each of its subsidiaries owns or possesses legally enforceable rights to use all patents, patent rights, inventions,
trademarks, trademark applications, trade names, service marks, copyrights, copyright applications, licenses, know-how and other
similar rights and proprietary knowledge (collectively, “Intangibles”) necessary for the conduct of its business. Neither
the Company nor any of its subsidiaries has received any notice of, or is aware of, any infringement of or conflict with asserted
rights of others with respect to any Intangibles, except for any of the foregoing that would not reasonably be expected to have
a Material Adverse Effect.
(j) The
Company and each of its subsidiaries has good and marketable title in fee simple to all real property, and good and marketable
title to all other property owned by it, in each case free and clear of all liens, encumbrances, claims, security interests and
defects, except such as do not materially affect the value of such property and do not materially interfere with the use made or
proposed to be made of such property by the Company and its subsidiaries. All property held under lease by the Company and its
subsidiaries is held by them under valid, existing and enforceable leases, free and clear of all liens, encumbrances, claims, security
interests and defects, except such as are not material and do not materially interfere with the use made or proposed to be made
of such property by the Company and its subsidiaries.
(k) Subsequent
to the respective dates as of which information is given in the Registration Statement, the Statutory Prospectus and the Prospectus,
(i) there has not been any event which could reasonably be expected to have a Material Adverse Effect; (ii) neither the Company
nor any of its subsidiaries has sustained any loss or interference with its assets, businesses or properties (whether owned or
leased) from fire, explosion, earthquake, flood or other calamity, whether or not covered by insurance, or from any labor dispute
or any court or legislative or other governmental action, order or decree which would reasonably be expected to have a Material
Adverse Effect; and (iii) since the date of the latest balance sheet included in the Registration Statement and the Prospectus
and except as described in the Registration Statement and Prospectus, neither the Company nor its subsidiaries has (A) issued any
securities other than Ordinary Shares issued pursuant to employee benefit plans, qualified stock option plans or other employee
compensation plans or pursuant to outstanding options, (B) incurred any liability or obligation, direct or contingent, for borrowed
money, except such liabilities or obligations incurred in the ordinary course of business, (C) entered into any material transaction
not in the ordinary course of business or (D) declared or paid any dividend or made any distribution on any shares of its stock
or redeemed, purchased or otherwise acquired or agreed to redeem, purchase or otherwise acquire any shares of its capital stock.
(l) There
is no document, contract or other agreement required to be described in the Registration Statement, the ADS Registration Statement,
the Statutory Prospectus or the Prospectus or to be filed as an exhibit to the Registration Statement which is not described or
filed as required by the Securities Act or Rules. Each description of a contract, document or other agreement in the Registration
Statement, the ADS Registration Statement, the Statutory Prospectus or the Prospectus accurately reflects in all material respects
the terms of the underlying contract, document or other agreement. Each contract, document or other agreement described in the
Registration Statement, the ADS Registration Statement, the Statutory Prospectus or the Prospectus or listed in the exhibits to
the Registration Statement or the ADS Registration Statement is in full force and effect and is valid and enforceable by and against
the Company or its subsidiaries, as the case may be, in accordance with its terms. Neither the Company nor any of its subsidiaries,
if a subsidiary is a party, nor to the Company’s knowledge, any other party, is in default in the observance or performance
of any term or obligation to be performed by it under any such agreement, and no event has occurred which with notice or lapse
of time or both would constitute such a default or result in the creation or imposition of any lien, charge, mortgage, pledge,
security interest, claim, limitation on voting rights, equity, trust or other encumbrance, preferential arrangement, defect or
restriction of any kind whatsoever, upon, any property or assets of the Company or any subsidiary pursuant to, any bond, debenture,
note, indenture, mortgage, deed of trust, loan agreement or other agreement or instrument to which it is a party or by which it
is bound or to which any of its properties or assets is subject, in any such case which default or event, individually or in the
aggregate, would reasonably be expected to have a Material Adverse Effect. No default exists, and no event has occurred which with
notice or lapse of time or both would constitute a default, in the due performance and observance of any term, covenant or condition,
by the Company or its subsidiaries, if a subsidiary is a party thereto, of any other agreement or instrument to which the Company
or any of its subsidiaries is a party or by which Company or its properties or business or a subsidiary or its properties or business
may be bound or affected which default or event, individually or in the aggregate, would reasonably be expected to have a Material
Adverse Effect.
(m) The
statistical and market related data included in the Registration Statement, the Statutory Prospectus or the Prospectus are based
on or derived from sources that the Company believes to be reliable and accurate.
(n) Neither
the Company nor any subsidiary (i) is in violation of its certificate or articles of incorporation, articles of association, by-laws,
certificate of formation, limited liability company agreement, partnership agreement or other organizational documents, (ii) is
in violation of any instrument or approval granted to any of them by the Israel Innovation Authority (formerly the Office of the
Chief Scientist) of the Israeli Ministry of Economy and Industry (the “IIA”), or (iii) is in violation of any statute,
law, rule, regulation, ordinance, directive, judgment, decree or order of any judicial, regulatory or other legal or governmental
agency or body, foreign or domestic, except in the case of clauses (ii) and (iii) to the extent such default or violation would
not, individually or in the aggregate, reasonably be expected to have a Material Adverse Effect.
(o) This
Agreement has been duly authorized, executed and delivered by the Company;
(p) Neither
the execution, delivery and performance of this Agreement by the Company nor the consummation of any of the transactions contemplated
hereby (including, without limitation, the issuance and sale by the Company of the Shares) will give rise to a right to terminate
or accelerate the due date of any payment due under, or conflict with or result in the breach of any term or provision of, or constitute
a default (or an event which with notice or lapse of time or both would constitute a default) under, or require any consent or
waiver under, or result in the execution or imposition of any lien, charge or encumbrance upon any properties or assets of the
Company or its subsidiaries pursuant to the terms of, (i) any indenture, mortgage, deed of trust or other agreement or instrument
to which the Company or any of its subsidiaries is a party or by which either the Company or its subsidiaries or any of their properties
or businesses is bound, or (ii) any franchise, license, permit, judgment, decree, order, statute, rule or regulation applicable
to the Company or any of its subsidiaries or (iii) violate any provision of the articles of association, charter or by-laws or
other organizational documents of the Company or any of its subsidiaries; except for such consents or waivers which have already
been obtained and are in full force and effect and except, with respect to clauses (i) and (ii), conflicts or violations that would
not reasonably be expected to have a Material Adverse Effect.
(q) The
Company has authorized and outstanding share capital as set forth under the caption “Capitalization” in the Statutory
Prospectus and the Prospectus. All of the issued and outstanding shares of the Company have been duly and validly issued and are
fully paid and nonassessable and have been issued in compliance with all federal, state and local, including any applicable foreign
(including Israeli), securities laws. There are no statutory preemptive or other similar rights to subscribe for or to purchase
or acquire any shares of the Company or any of its subsidiaries, including Ordinary Shares or ADSs, or any such rights pursuant
to its articles of association, charter, certificate of incorporation or by-laws or any other applicable organization documents
or any agreement or instrument to or by which the Company or any of its subsidiaries is a party or bound. The Shares (including
the underlying Ordinary Shares) have been duly authorized for issuance and sale pursuant to this Agreement and when issued and
sold pursuant to this Agreement, will be duly and validly issued, fully paid and nonassessable and none of them will be issued
in violation of any preemptive or other similar right. Except as disclosed in the Registration Statement, the Statutory Prospectus
and the Prospectus, there is no outstanding option, warrant or other right calling for the issuance of, and there is no commitment,
plan or arrangement to issue, any shares of the Company or any of its subsidiaries or any security convertible into, or exercisable
or exchangeable for, such shares. Except for certain options to acquire Ordinary Shares issued to officers, employees and other
service providers of the Company with an exercise price equal to the average closing price during the month preceding their respective
dates of grant (which exercise price was consistent with Israeli practice and the requirements of Israeli tax law at the time of
grant), the exercise price of each option to acquire Ordinary Shares (each, a “Company Stock Option”) is no less than
the fair market value of an Ordinary Share as determined on the date of grant of such Company Stock Option. All grants of Company
Stock Options were validly issued and properly approved by the Board of Directors of the Company (and, if required, by a committee
of the Board of Directors of the Company and/or the shareholders of the Company) in material compliance with all applicable laws
and the terms of the plans under which such Company Stock Options were issued and were recorded on the Company’s financial
statements, in accordance with IFRS as issued by the International Accounting Standards Board, and no such grants involved any
“back dating,” “forward dating,” “spring loading” or similar practices with respect to the
effective date of grant. The Ordinary Shares and the Shares conform in all material respects to all statements in relation thereto
contained in the Registration Statement and the Statutory Prospectus and the Prospectus.
(r) No
holder of any security of the Company has any right, which has not been waived, to have any security owned by such holder included
in the Registration Statement or to demand registration of any security owned by such holder for a period of 180 days after the
date of this Agreement. Each director and executive officer of the Company and each shareholder of the Company listed on Schedule
II hereto has delivered to the Representative a lock-up agreement in the form attached to this Agreement as Exhibit A hereto (“Lock-Up
Agreement”).
(s) There
are no legal or governmental proceedings pending to which the Company or any of its subsidiaries is a party or of which any property
of the Company or any of its subsidiaries is the subject which, if determined adversely to the Company or any of its subsidiaries
could, individually or in the aggregate, reasonably be expected to have a Material Adverse Effect; and, to the knowledge of the
Company, no such proceedings are threatened or contemplated by governmental authorities or threatened by others.
(t) All
necessary corporate action has been duly and validly taken by the Company to authorize the execution, delivery and performance
of this Agreement and the issuance and sale of the Shares by the Company, including, if applicable, such corporate approvals on
the part of the Company under Chapter 5 of Part VI of the Israeli Companies Law.
(u) Neither
the Company nor any of its subsidiaries is involved in any labor dispute nor, to the knowledge of the Company, is any such dispute
threatened, which dispute would reasonably be expected to have a Material Adverse Effect. The Company is not aware of any existing
or imminent labor disturbance by the employees of any of its principal suppliers or contractors which would reasonably be expected
to have a Material Adverse Effect. The Company is not aware of any threatened or pending litigation between the Company or its
subsidiaries and any of its executive officers which, if adversely determined, could reasonably be expected to have a Material
Adverse Effect and has no reason to believe that such officers will not remain in the employment of the Company.
(v) No
transaction has occurred between or among the Company and any of its officers or directors, shareholders or any affiliate or affiliates
of any such officer or director or shareholder that is required to be described in and is not described in the Registration Statement,
the Statutory Prospectus and the Prospectus.
(w) The
Company has not taken, nor will it take, directly or indirectly, any action designed to, or which might reasonably be expected
to cause or result in, or which has constituted or which might reasonably be expected to constitute, the stabilization or manipulation
of the price of the Ordinary Shares or any security of the Company to facilitate the sale or resale of any of the Shares.
(x) The
Company and each of its subsidiaries has filed all federal, state, local and foreign tax returns which are required to be filed
through the date hereof (except in any case in which the failure to so file would not result in a Material Adverse Effect), which
returns are true and correct in all material respects or has received timely extensions thereof, and has paid all taxes shown on
such returns and all assessments received by it to the extent that the same are material and have become due. There are no tax
audits or investigations pending, which if adversely determined would reasonably be expected to have a Material Adverse Effect;
nor are there any material proposed additional tax assessments against the Company or any of its subsidiaries.
(y) The
ADSs have been duly authorized for quotation on the National Association of Securities Dealers Automated Quotation (“Nasdaq”)
Capital Market System, subject to official Notice of Issuance. A registration statement for the ADSs has been filed on Form 8-A
pursuant to Section 12 of the Exchange Act, which registration statement complies in all material respects with the Exchange Act.
(z) The
Company has taken no action designed to, or likely to have the effect of, terminating the registration of the ADSs under the Exchange
Act or the quotation of the ADSs on the Nasdaq Capital Market, nor has the Company received any notification that the Commission
or the Nasdaq Capital Market is contemplating terminating such registration or quotation.
(aa) The
Company and its subsidiaries maintain a system of internal accounting controls sufficient to provide reasonable assurances that
(i) transactions are executed in accordance with management’s general or specific authorizations, (ii) transactions are recorded
as necessary to permit preparation of financial statements in accordance with IFRS and to maintain asset accountability, (iii)
access to assets is permitted only in accordance with management’s general or specific authorization and (iv) the recorded
accountability for assets is compared with the existing assets at reasonable intervals and appropriate action is taken with respect
to any differences.
(bb) The
Company maintains disclosure controls and procedures (as such term is defined in Rule 13a-15 under the Exchange Act), which: (i)
are designed to ensure that material information relating to the Company is made known to the Company’s principal executive
officer and its principal financial officer by others within the Company, particularly during the periods in which the periodic
reports required under the Exchange Act are required to be prepared; (ii) provide for the periodic evaluation of the effectiveness
of such disclosure controls and procedures at the end of the periods in which the periodic reports are required to be prepared;
and (iii) are effective in all material respects to perform the functions for which they were established.
(cc) Based
on the evaluation of its disclosure controls and procedures, the Company is not aware of (i) any material weakness or significant
deficiency in the design or operation of internal controls which could adversely affect the Company’s ability to record,
process, summarize and report financial data or any material weaknesses in internal controls; or (ii) any fraud, whether or not
material, that involves management or other employees who have a role in the Company’s internal controls.
(dd) Except
as described in the Statutory Prospectus and the Prospectus and as preapproved in accordance with the requirements set forth in
Section 10A of the Exchange Act, the Auditor has not been engaged by the Company to perform any “prohibited activities”
(as defined in Section 10A of the Exchange Act).
(ee) Except
as described in the Statutory Prospectus and the Prospectus, there are no material off-balance sheet arrangements (as defined in
Item 303 of Regulation S-K) that have or are reasonably likely to have a material current or future effect on the Company’s
financial condition, revenues or expenses, changes in financial condition, results of operations, liquidity, capital expenditures
or capital resources.
(ff) The
Company is in compliance with all applicable provisions of the Sarbanes-Oxley Act of 2002, as amended (the “Sarbanes-Oxley
Act”), any related rules and regulations promulgated by the Commission and corporate governance requirements under applicable
Nasdaq regulations upon the effectiveness of such provisions and has no reason to believe that it will not be able to comply with
such provisions at the time of effectiveness.
(gg) The
Company and its subsidiaries are insured by insurers of recognized financial responsibility against such losses and risks and in
such amounts as are customary in the businesses in which they are engaged or propose to engage after giving effect to the transactions
described in the Statutory Prospectus and the Prospectus; all policies of insurance and fidelity or surety bonds insuring the Company
or any of its subsidiaries or the Company’s or its subsidiaries’ respective businesses, assets, employees, officers
and directors are in full force and effect; the Company and each of its subsidiaries are in compliance with the terms of such policies
and instruments in all material respects; and neither the Company nor any subsidiary has any reason to believe that it will not
be able to renew its existing insurance coverage as and when such coverage expires or to obtain similar coverage from similar insurers
as may be necessary to continue its business at a cost that is not materially greater than the current cost. Neither the Company
nor any of its subsidiaries has been denied any insurance coverage which it has sought or for which it has applied.
(hh) Each
approval, consent, order, authorization, designation, declaration or filing of, by or with any regulatory, administrative or other
governmental body necessary in connection with the execution and delivery by the Company of this Agreement and the consummation
of the transactions herein contemplated required to be obtained or performed by the Company (except for (i) such additional steps
as may be required by the Financial Industry Regulatory Authority (“FINRA”); (ii) as may be necessary to qualify the
Shares for public offering by the Underwriters under the state securities or Blue Sky laws; (iii) the approval by the Nasdaq Capital
Market for the listing of the Shares on the Nasdaq Capital Market; and (iv) the filing of a notice of the Offering with the IIA
has been obtained or made and is in full force and effect. Assuming the Underwriters have not offered the Shares in Israel, or
otherwise engaged in a solicitation, advertising or any other action in Israel constituting an offer under the Israeli Securities
Law, 5728-1968, as amended, and the regulations promulgated thereunder, other than an offer that does not constitute an offering
to the public, the Company is not required to publish a prospectus in the State of Israel under the laws of the State of Israel
with respect to the offer or sale of the Shares.
(ii) There
are no affiliations with FINRA among the Company’s officers, directors or, to the best of the knowledge of the Company, any
five percent or greater shareholder of the Company, except as set forth in the Registration Statement or otherwise disclosed in
writing to the Representative.
(jj) Except
as described in the Registration Statement and except as would not be reasonably expected, individually or in the aggregate, to
have a Material Adverse Effect, (i) each of the Company and each of its subsidiaries is in compliance in all respects with all
rules, laws and regulation relating to the use, treatment, storage and disposal of toxic substances and protection of health or
the environment (each such law, an “Environmental Law”) which are applicable to its business; (ii) neither the Company
nor its subsidiaries has received any notice from any governmental authority or third party of an asserted claim under Environmental
Laws; (iii) each of the Company and each of its subsidiaries has received all permits, licenses or other approvals required of
it under applicable Environmental Laws to conduct its business and is in compliance with all terms and conditions of any such permit,
license or approval; (iv) to the Company’s knowledge, no facts currently exist that will require the Company or any of its
subsidiaries to make future material capital expenditures to comply with Environmental Laws; and (v) no property which is or has
been owned, leased or occupied by the Company or its subsidiaries has been designated as a Superfund site pursuant to the Comprehensive
Environmental Response, Compensation of Liability Act of 1980, as amended (42 U.S.C. Section 9601, et. seq.) or otherwise designated
as a contaminated site under other Environmental Laws. Neither the Company nor any of its subsidiaries has been named as a “potentially
responsible party” under the CERCLA 1980.
(kk) The
Company is not and, after giving effect to the offering and sale of the Shares and the application of proceeds thereof as described
in the Statutory Prospectus and the Prospectus, will not be an “investment company” within the meaning of the Investment
Company Act of 1940, as amended (the “Investment Company Act”).
(ll) Neither
the Company, nor, to the Company's knowledge, any director, officer, agent or employee of the Company or its subsidiaries, has
not, directly or indirectly, while acting on behalf of the Company or its subsidiaries (i) used any corporate funds for unlawful
contributions, gifts, entertainment or other unlawful expenses relating to political activity; (ii) made any unlawful payment
to foreign or domestic government officials or employees or to foreign or domestic political parties or campaigns from corporate
funds; (iii) violated any provision of the Foreign Corrupt Practices Act of 1977, as amended, or any provision of any applicable
non-U.S. anti-bribery or anti-corruption law or regulation; or (iv) made any other unlawful payment.
(mm) The
operations of the Company and its subsidiaries are and have been conducted at all times in compliance with applicable financial
recordkeeping and reporting requirements of the Currency and Foreign Transactions Reporting Act of 1970, as amended, the money
laundering statutes of all applicable jurisdictions, the rules and regulations thereunder and any related or similar rules, regulations
or guidelines, issued, administered or enforced by any governmental agency (collectively, the “Money Laundering Laws”)
and no action, suit or proceeding by or before any court or governmental agency, authority or body or any arbitrator involving
the Company or any of its subsidiaries with respect to the Money Laundering Laws is pending, or to the best knowledge of the Company,
threatened.
(nn) Neither
the Company nor any of its subsidiaries nor, to the knowledge of the Company, any director or officer of the Company or any of
its subsidiaries, is currently subject to any U.S. sanctions administered by the Office of Foreign Assets Control of the U.S. Treasury
Department (“OFAC”); and the Company will not directly or indirectly use the proceeds of the offering, or lend, contribute
or otherwise make available such proceeds to any subsidiary, joint venture partner or other person or entity, for the purpose of
financing the activities of any person currently subject to any U.S. sanctions administered by OFAC.
(oo) The
Company has fulfilled its obligations, if any, under the minimum funding standards of Section 302 of the U.S. Employee Retirement
Income Security Act of 1974 (“ERISA”) and the regulations and published interpretations thereunder with respect to
each “plan” as defined in Section 3(3) of ERISA and such regulations and published interpretations in which its employees
are eligible to participate and each such plan is in compliance in all material respects with the presently applicable provisions
of ERISA and such regulations and published interpretations. No “Reportable Event” (as defined in 12 ERISA) has occurred
with respect to any “Pension Plan” (as defined in ERISA) for which the Company could have any liability.
(pp) None
of the Company, its directors or its officers has distributed nor will distribute prior to the later of (i) the Firm Shares Closing
Date, or the Option Shares Closing Date, and (ii) completion of the distribution of the Shares, any offering material in connection
with the offering and sale of the Shares other than any Preliminary Prospectus, the Prospectus, the Registration Statement and
other materials, if any, permitted by the Securities Act and consistent with the terms of this Agreement.
(qq) Since
the date of the preliminary prospectus included in the Registration Statement filed with the Commission on September 28, 2018 (or,
if earlier, the first date on which the Company engaged directly or through any Person authorized to act on its behalf in any Testing-the-Waters
Communication (as defined herein)) through the date hereof, the Company has been and is an “emerging growth company,”
as defined in Section 2(a) of the Securities Act (an “Emerging Growth Company”). “Testing-the-Waters Communication”
means any oral or written communication with potential investors undertaken in reliance on Section 5(d) of the Securities Act.
(rr) The
Company (a) has not alone engaged in any Testing-the-Waters Communication other than Testing-the-Waters Communications with the
consent of the Representative with entities that are qualified institutional buyers within the meaning of Rule 144A under the Securities
Act or institutions that are accredited investors within the meaning of Rule 501 under the Securities Act, and (b) has not authorized
anyone other than the Representative to engage in Testing-the-Waters Communications. The Company reconfirms that the Representative
has been authorized to act on its behalf in undertaking Testing-the-Waters Communications. The Company has not distributed any
Written Testing-the-Waters Communications. “Written Testing-the-Waters Communication” means any Testing-the-Waters
Communication that is a written communication within the meaning of Rule 405 under the Securities Act.
(ss) The
Company has the power to submit, and pursuant to Section 9 of this Agreement, has legally, validly, effectively and irrevocably
submitted, to the personal jurisdiction of each United States federal court and New York state court located in the Borough of
Manhattan, in the City of New York, New York, U.S.A. (each, a “New York Court”), and the Company has the power to designate,
appoint and authorize, and pursuant to Section 9 of this Agreement, has legally, validly, effectively and irrevocably designated,
appointed and authorized an agent for service of process in any action arising out of or relating to this Agreement in any New
York Court, and service of process effected on such authorized agent will be effective to confer valid personal jurisdiction over
the Company as provided in Section 10 hereof.
(tt) The
Company is a “foreign private issuer” within the meaning of Rule 405 under the Securities Act.
(uu) The
Company and each of its subsidiaries has all requisite corporate power and authority, and all necessary authorizations, approvals,
consents, orders, licenses, certificates and permits of and from all governmental or regulatory bodies or any other person or entity
(collectively, the “Permits”), to own, lease and license its assets and properties and conduct its business, all of
which are valid and in full force and effect, except where the lack of such Permits, individually or in the aggregate, would not
reasonably be expected to have a Material Adverse Effect. The Company and each of its subsidiaries has fulfilled and performed
all of its obligations with respect to such Permits and no event has occurred that allows, or after notice or lapse of time would
allow, revocation or termination thereof or results in any other impairment of the rights of the Company thereunder, except for
any of the foregoing that would not, individually or in the aggregate, reasonably be expected to have a Material Adverse Effect.
Except as may be required under the Securities Act and state and foreign Blue Sky laws, no other Permits are required to enter
into, deliver and perform this Agreement and to issue and sell the Shares.
(vv) The
Deposit Agreement has been duly authorized by the Company, and when executed and delivered by the Company will, assuming due authorization,
execution and delivery by the Depository, constitute a valid and legally binding obligation of the Company, enforceable against
the Company in accordance with its terms, except as may be limited by applicable bankruptcy, insolvency, reorganization, moratorium
or other similar laws relating to or affecting creditors’ rights generally or general equitable principles. Upon the issuance,
sale and payment for the underlying Ordinary Shares in accordance with the terms hereof and the due issuance by the Depository
of the ADSs against the deposit of the underlying Ordinary Shares in respect thereof in accordance with the provisions of the Deposit
Agreement, such Shares will be duly and validly issued, and the persons in whose names the ADSs are registered will be entitled
to the rights specified in the Deposit Agreement; and the Deposit Agreement and the ADRs conform in all material respects to the
descriptions thereof contained in the Registration Statement and the Prospectus.
(ww) No
transaction, stamp or other issuance or transfer taxes or duties, and, assuming that the Underwriters are not otherwise subject
to taxation in Israel, no capital gain, income, or other tax or duty is payable in the State of Israel by or on behalf of the Underwriters
to any taxing authority thereof or therein in connection with (i) the issuance, sale and delivery of the Shares by the Company;
(ii) the purchase from the Company, and the initial sale and delivery by the Underwriters of the Shares to purchasers thereof;
(iii) the holding or transfer of the Shares in connection with (ii) above; or (iv) the execution and delivery of this Agreement
or any other document to be furnished hereunder.
3.
Conditions
of the Underwriters’ Obligations
. The obligations of the Underwriters under this Agreement are several and not joint.
The respective obligations of the Underwriters to purchase the Shares are subject to each of the following terms and conditions:
(a) Notification
that each of the Registration Statement and the ADS Registration Statement has become effective shall have been received by the
Representative and the Prospectus shall have been timely filed with the Commission in accordance with Section 4(a) of this Agreement
and any material required to be filed by the Company pursuant to Rule 433(d) of the Rules shall have been timely filed with the
Commission in accordance with such rule.
(b) No
order preventing or suspending the use of any Preliminary Prospectus, the Prospectus or any Issuer Free Writing Prospectus shall
have been or shall be in effect and no order suspending the effectiveness of the Registration Statement shall be in effect and
no proceedings for such purpose shall be pending before or, to the Company’s knowledge, threatened by the Commission, and
any requests for additional information on the part of the Commission (to be included in the Registration Statement or the Prospectus
or otherwise) shall have been complied with to the satisfaction of the Commission and the Representative. If the Company has elected
to rely upon Rule 430A, Rule 430A information previously omitted from the effective Registration Statement pursuant to Rule 430A
shall have been transmitted to the Commission for filing pursuant to Rule 424(b) within the prescribed time period and the Company
shall have provided evidence satisfactory to the Underwriters of such timely filing, or a post-effective amendment providing such
information shall have been promptly filed and declared effective in accordance with the requirements of Rule 430A.
(c) The
representations and warranties of the Company contained in this Agreement and in the certificates delivered pursuant to Section
3(d) shall be true and correct when made and on and as of each Closing Date as if made on such date. The Company shall have performed
all covenants and agreements and satisfied all the conditions contained in this Agreement required to be performed or satisfied
by them at or before such Closing Date.
(d) The
Representative shall have received on each Closing Date a certificate, addressed to the Representative and dated such Closing Date,
of the chief executive or chief operating officer and the chief financial officer or chief accounting officer of the Company to
the effect that: (i) the representations, warranties and agreements of the Company in this Agreement were true and correct when
made and are true and correct as of such Closing Date in all material respects (to the extent not otherwise qualified by materiality);
(ii) the Company has performed all covenants and agreements and satisfied all conditions contained herein; (iii) they have carefully
examined the Registration Statement, the ADS Registration Statement, the Prospectus, the General Disclosure Package, and any individual
Issuer Free Writing Prospectus and, in their opinion (A) as of the Effective Date the Registration Statement and Prospectus did
not include, and as of the Applicable Time, neither (i) the General Disclosure Package, nor (ii) any individual Issuer
Free Writing Prospectus, when considered together with the General Disclosure Package, nor (iii) as of the date it became effective,
the ADS Registration Statement, included any untrue statement of a material fact and did not omit to state a material fact required
to be stated therein or necessary to make the statements therein, in the light of the circumstances under which they were made,
not misleading, and (B) since the Effective Date, no event has occurred which should have been set forth in a supplement or otherwise
required an amendment to the Registration Statement, the ADS Registration Statement, the Statutory Prospectus or the Prospectus;
and (iv) no stop order suspending the effectiveness of the Registration Statement has been issued and, to their knowledge, no proceedings
for that purpose have been instituted or are pending under the Securities Act.
(e) The
Representative shall have received: (i) simultaneously with the execution of this Agreement, a signed letter from the Auditor addressed
to the Representative and dated the date of this Agreement, in form and substance reasonably satisfactory to the Representative,
containing statements and information of the type ordinarily included in accountants’ “comfort letters” to underwriters
with respect to the financial statements and certain financial information contained in the Registration Statement and the Disclosure
Package, and (ii) on each Closing Date, a signed letter from the Auditor addressed to the Representative and dated the date of
such Closing Date(s), in form and substance reasonably satisfactory to the Representative containing statements and information
of the type ordinarily included in accountants’ “comfort letters” to underwriters with respect to the financial
statements and certain financial information contained in the Registration Statement and the Prospectus.
(f) The
Representative shall have received on each Closing Date from each of Mayer Brown LLP and Goldfarb Seligman & Co., counsel for
the Company, an opinion and negative assurance statement, addressed to the Representative and dated such Closing Date, in form
and substance reasonably satisfactory to the Representative.
(g) The
Representative shall have received on each Closing Date from Reinhard Cohn & Partners,
intellectual property counsel for the Company, an opinion and written negative assurances statement, addressed to the Representative
and dated such Closing Date, in form and substance satisfactory to the Representative.
(h) On the Closing Date, the Representative shall
have received the opinion of Emmet, Marvin & Martin, LLP, counsel for the Depository, dated the Closing Date, addressed to
the Representative in form and substance satisfactory to the Representative.
(i) The
Representative shall have received on the Closing Date from each of Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C. and Zysman,
Aharoni, Gayer & Co., counsel for the Representative, a negative assurance statement, addressed to the Representative and
dated as of such Closing Date, with respect to such matters as the Representative may reasonably require, and the Company shall
have furnished or provided access to such counsel of such documents as they request for enabling them to pass upon such matters.
(j) The
Representative shall have received copies of the Lock-Up Agreements executed by each entity or person listed on Schedule II hereto.
In the event that Oppenheimer & Co. Inc., in its sole discretion, agrees to release or waive any restriction set forth in a
Lock-Up Agreement for an officer or director of the Company, and provides the Company with notice of the impending release or waiver
at least three Business Days before the effective date of such release or waiver (which release or waiver shall be substantially
in the Form found at Exhibit A-1 attached hereto), the Company agrees to announce the impending release or waiver by a press release
substantially in the form of Exhibit A-2 attached hereto through a major news service at least two Business Days before the effective
date of the release or waiver
.
(k) The
Shares shall have been approved for quotation on the Nasdaq Capital Market, subject only to official notice of issuance, and the
TASE has approved the registration of the Ordinary Shares.
(l)
The
Representative shall be reasonably satisfied that since the respective dates as of which information is given in the Registration
Statement, the Statutory Prospectus, the General Disclosure Package and the Prospectus, (i) there shall not have been any material
change in the capital stock of the Company or any material change in the indebtedness (other than in the ordinary course of business)
of the Company, (ii) except as set forth or contemplated by the Registration Statement, the Statutory Prospectus, the General
Disclosure Package or the Prospectus, no material oral or written agreement or other transaction shall have been entered into
by the Company that is not in the ordinary course of business or that could reasonably be expected to result in a material adverse
change in the results of operations of the Company, (iii) no loss or damage (whether or not insured) to the property of the Company
shall have been sustained that had or could reasonably be expected to have a Material Adverse Effect, (iv) no legal or governmental
action, suit or proceeding affecting the Company or any of its properties that is material to the Company or that affects or could
reasonably be expected to affect the transactions contemplated by this Agreement shall have been instituted or threatened and
(v) there shall not have been any material adverse change in the assets, properties, condition (financial or otherwise), or in
the results of operations, business affairs or business prospects of the Company or its subsidiaries considered as a whole that
makes it impractical or inadvisable in the Representative’s judgment to proceed with the purchase or offering of the Shares
as contemplated hereby.
(m) FINRA
shall have confirmed that it has not raised any objection with respect to the fairness and reasonableness of the underwriting
terms and agreements in connection with the offering of the Shares.
(n) The
Company and the Depository shall have executed and delivered the Deposit Agreement and the Deposit Agreement shall be in full
force and effect and the Company and the Depository shall have taken all action necessary to permit the deposit of the Ordinary
Shares and the issuance of the Shares in accordance with the Deposit Agreement. The Company shall, prior to the Closing Date,
as the case may be, deposit the Ordinary Shares to be represented by the Shares with the Depository in accordance with the provisions
of the Deposit Agreement and otherwise comply with the Deposit Agreement so that the ADSs will be issued by the Depository against
receipt of such Ordinary Shares and delivered to the Underwriters at the Closing Dates.
(o) At
each Closing Date, the Representative shall have received a certificate from the Depository satisfactory to the Representative
with respect to the deposit with the Depository of the underlying Ordinary Shares represented by the Shares against issuance of
the ADRs evidencing the Shares, the execution, issuance, countersignature and delivery of the ADRs evidencing the Shares pursuant
to the Deposit Agreement and such other matters related thereto as the Representative may reasonably request.
(q) The
Company shall have furnished or caused to be furnished to the Representative such further certificates or documents as the Representative
shall have reasonably requested.
4.
Covenants
and Other Agreements of the Company and the Underwriters
.
(a) The
Company covenants and agrees as follows:
(i) The
Company will use its commercially reasonable efforts to cause the Registration Statement and the ADS Registration Statement, if
not effective at the time of execution of this Agreement, and any amendments thereto, to become effective as promptly as possible.
The Company shall prepare the Prospectus in a form approved by the Representative and file such Prospectus pursuant to Rule 424(b)
under the Securities Act not later than the Commission’s close of business on the second business day following the execution
and delivery of this Agreement, or, if applicable, such earlier time as may be required by the Rules. The Company will file with
the Commission all Issuer Free Writing Prospectuses in the time and manner required under Rules 433(d) or 163(b)(2), as the
case may be.
(ii) The
Company shall promptly advise the Representative in writing (A) when any post-effective amendment to the Registration Statement
shall have become effective or any supplement to the Prospectus shall have been filed, (B) of any request by the Commission for
any amendment of the Registration Statement, the ADS Registration Statement or the Prospectus or for any additional information,
(C) of the issuance by the Commission of any stop order suspending the effectiveness of the Registration Statement or of any order
preventing or suspending the use of any preliminary prospectus or any “free writing prospectus,” as defined in Rule
405 of the Rules, or the institution or threatening of any proceeding for that purpose and (D) of the receipt by the Company of
any notification with respect to the suspension of the qualification of the Shares for sale in any jurisdiction or the initiation
or threatening of any proceeding for such purpose. Prior to filing any amendment of the Registration Statement or supplement to
the Prospectus or any Issuer Free Writing Prospectus, the Company shall furnish a copy thereof to the Representative and obtain
the consent of the Representative prior to filing, which consent shall not be unreasonably withheld. The Company shall use its
commercially reasonable efforts to prevent the issuance of any such stop order and, if issued, to obtain as soon as possible the
withdrawal thereof. The Company has complied and will comply with the requirements of Rule 433 under the Act applicable to any
Issuer Free Writing Prospectus, including timely filing with the Commission where required, legending and record keeping.
(iii) If,
at any time when a prospectus relating to the Shares (or, in lieu thereof, the notice referred to in Rule 173(a) of the Rules)
is required to be delivered under the Securities Act, any event occurs as a result of which the Prospectus as then amended or supplemented
would include any untrue statement of a material fact or omit to state any material fact necessary to make the statements therein
in the light of the circumstances under which they were made not misleading, or if it shall be necessary to amend or supplement
the Prospectus to comply with the Securities Act or the Rules, the Company promptly shall prepare and file with the Commission,
subject to the second sentence of paragraph (ii) of this Section 4(a), an amendment or supplement which shall correct such statement
or omission or an amendment which shall effect such compliance.
(iv) If
at any time following issuance of an Issuer Free Writing Prospectus there occurs an event or development as a result of which
such Issuer Free Writing Prospectus would conflict with the information contained in the Registration Statement or would include
an untrue statement of a material fact or would omit to state a material fact required to be stated therein or necessary in order
to make the statements therein, in the light of the circumstances prevailing at the subsequent time, not misleading, the Company
will promptly notify the Representative and will promptly amend or supplement, at its own expense, such Issuer Free Writing Prospectus
to eliminate or correct such conflict, untrue statement or omission.
(v) The
Company shall make generally available to its security holders and to the Representative as soon as practicable, but not later
than 410 days after the Effective Date (or 545 days if the fourth quarter following the fiscal quarter that includes the Effective
Date is the last fiscal quarter of the Company’s fiscal year) an earning statement (which need not be audited) of the Company
covering the 12-month period beginning at the end of the fiscal quarter of the Company during which the Effective Date occurs,
which shall satisfy the provisions of Section 11(a) of the Securities Act or Rule 158 of the Rules.
(vi) The
Company shall furnish upon request to the Representative and counsel for the Underwriters, without charge, signed copies of the
Registration Statement (including all exhibits thereto and amendments thereof) and to each other Underwriter a copy of the Registration
Statement (without exhibits thereto) and all amendments thereof and, so long as delivery of a prospectus by an Underwriter or dealer
may be required by the Securities Act or the Rules, as many copies of any Preliminary Prospectus, any Issuer Free Writing Prospectus
and the Prospectus and any amendments thereof and supplements thereto as the Representative may reasonably request. If applicable,
the copies of the Registration Statement, preliminary prospectus, any Issuer Free Writing Prospectus and Prospectus and each amendment
and supplement thereto furnished to the Underwriters will be identical to the electronically transmitted copies thereof filed with
the Commission pursuant to EDGAR, except to the extent permitted by Regulation S-T.
(vii) The
Company shall cooperate with the Representative and its counsel in endeavoring to qualify the Shares for offer and sale in connection
with the offering under the laws of such jurisdictions as the Representative may designate and shall maintain such qualifications
in effect so long as required for the distribution of the Shares.
(viii) The
Company, during the period when the Prospectus (or in lieu thereof, the notice referred to in Rule 173(a) of the Rules) is required
to be delivered under the Securities Act and the Rules or the Exchange Act, will file all reports and other documents required
to be filed with the Commission pursuant to Section 13, 14 or 15 of the Exchange Act within the time periods required by the Exchange
Act and the regulations promulgated thereunder.
(ix) Without
the prior written consent of the Representative, for a period of 180 days after the date of this Agreement, the Company and each
of its individual directors and executive officers shall not issue, sell or register with the Commission (other than on Form S-8
or on any successor form), or otherwise dispose of, directly or indirectly, any equity securities of the Company (or any securities
convertible into, exercisable for or exchangeable for equity securities of the Company), except for (A) the issuance of the Shares
pursuant to the Registration Statement, (B) the issuance of securities pursuant to the Company’s existing stock option plan
or bonus plan as described in the Registration Statement and the Prospectus, provided that the recipient of any such Ordinary Shares
or securities issued pursuant to the Company’s existing stock option plan or bonus plan that are exercisable or that may
become exercisable during the 180-day restricted period described above shall enter into an agreement substantially in the form
of Exhibit A hereto.
(x) On
or before completion of this offering, the Company shall make all filings required under applicable securities laws and by the
Nasdaq Capital Market (including any required registration under the Exchange Act). The Company shall use its commercially reasonable
efforts to maintain the listing or quotation of the ADSs on the Nasdaq Capital Market. The Company further agrees, if the Company
applies to have the ADSs traded on any other trading market, it will then include in such application the Shares and will take
such other action as is necessary to cause all of the Shares to be listed or quoted on such other trading market as promptly as
possible. The Company will then take all action reasonably necessary to continue the listing and trading of its ADSs on a trading
market and will comply in all material respects with the Company’s reporting, filing and other obligations under the bylaws
or rules of the trading market.
(xi) The
Company will apply the net proceeds from the offering of the Shares in the manner set forth under “Use of Proceeds”
in the Prospectus.
(xii) The
Company will promptly notify the Representative if the Company ceases to be an Emerging Growth Company at any time prior to the
later of (a) completion of the distribution of the Shares within the meaning of the Securities Act and (b) completion
of the 180-day restricted period referred to in Section 4(a)(ix) hereof.
(xiii) If
at any time following the distribution of any Written Testing-the-Waters Communication there occurred or occurs an event or development
as a result of which such Written Testing-the-Waters Communication included or would include an untrue statement of a material
fact or omitted or would omit to state a material fact necessary in order to make the statements therein, in the light of the circumstances
existing at that subsequent time, not misleading, the Company will promptly notify the Representative and will promptly amend or
supplement, at its own expense, such Written Testing-the-Waters Communication to eliminate or correct such untrue statement or
omission.
(b) The
Company agrees to pay, or reimburse if paid by the Representative, whether or not the transactions contemplated hereby are consummated
or this Agreement is terminated, all costs and expenses incident to the public offering of the Shares and the performance of the
obligations of the Company under this Agreement including those relating to: (i) the preparation, printing, reproduction filing
and distribution of the Registration Statement, including all exhibits thereto, each Preliminary Prospectus, the Prospectus, any
Issuer Free Writing Prospectus, all amendments and supplements thereto, and the printing, filing and distribution of this Agreement;
(ii) the preparation and delivery of certificates for the Shares to the Underwriters; (iii) the registration or qualification of
the Shares for offer and sale under the securities or Blue Sky laws of the various jurisdictions referred to in Section 4(a)(vii),
including the reasonable fees and disbursements of counsel for the Underwriters in connection with such registration and qualification
and the preparation, printing, distribution and shipment of preliminary and supplementary Blue Sky memoranda; (iv) the furnishing
(including costs of shipping and mailing) to the Representative and to the Underwriters of copies of each Preliminary Prospectus,
the Prospectus and all amendments or supplements to the Prospectus, any Issuer Free Writing Prospectus, and of the several documents
required by this Section to be so furnished, as may be reasonably requested for use in connection with the offering and sale of
the Shares by the Underwriters or by dealers to whom Shares may be sold; (v) the filing fees of FINRA in connection with its review
of the terms of the public offering and reasonable fees and disbursements of counsel for the Underwriters in connection with such
review; (vi) inclusion of the Shares for quotation on the Nasdaq Capital Market; (vii) all transfer taxes, if any, with respect
to the sale and delivery of the Shares by the Company to the Underwriters; and (viii) $75,000 to cover all costs and expenses incident
to the offering and the performance of the obligations of the Company under this Agreement, and all reasonable out-of-pocket costs
and expenses incident to the performance of the obligations of the Representative under this Agreement (including, without limitation,
the fees and expenses of Underwriters’ outside attorneys), provided that such amount may be increased (with the prior written
consent of the Company which shall not unreasonably be withheld) to an amount that shall not exceed $200,000.
(c) The
Company acknowledges and agrees that each of the Underwriters has acted and is acting solely in the capacity of a principal in
an length transaction between the Company, on the one hand, and the Underwriters, on the other hand, with respect to the offering
of Shares contemplated hereby (including in connection with determining the terms of the offering) and not as a financial advisor,
agent or fiduciary to the Company or any other person. Additionally, the Company acknowledges and agrees that the Underwriters
have not and will not advise the Company or any other person as to any legal, tax, investment, accounting or regulatory matters
in any jurisdiction. The Company has consulted with its own advisors concerning such matters and shall be responsible for making
its own independent investigation and appraisal of the transactions contemplated hereby, and the Underwriters shall have no responsibility
or liability to the Company or any other person with respect thereto, whether arising prior to or after the date hereof. Any review
by the Underwriters of the Company, the transactions contemplated hereby or other matters relating to such transactions have been
and will be performed solely for the benefit of the Underwriters and shall not be on behalf of the Company. The Company agrees
that it will not claim that the Underwriters, or any of them, has rendered advisory services of any nature or respect, or owes
a fiduciary duty to the company or any other person in connection with any such transaction or the process leading thereto.
5.
Indemnification
.
(a) The
Company agrees to indemnify and hold harmless each Underwriter, its officers and employees and each person, if any, who controls
any Underwriter within the meaning of Section 15 of the Securities Act or Section 20 of the Exchange Act against any and all losses,
claims, damages and liabilities, joint or several (including any reasonable investigation, legal and other expenses incurred in
connection with, and any amount paid in settlement of, any action, suit or proceeding or any claim asserted), to which they, or
any of them, may become subject under the Securities Act, the Exchange Act or other federal or state law or regulation, at common
law or otherwise, insofar as such losses, claims, damages or liabilities arise out of or are based upon any untrue statement or
alleged untrue statement of a material fact contained in any preliminary prospectus, the Registration Statement, the Statutory
Prospectus, the Prospectus, any Issuer Free Writing Prospectus or any “issuer-information” filed or required to be
filed pursuant to Rule 433(d) of the Rules, any amendment thereof or supplement thereto, any Written Testing-the-Waters Communication,
or in any Blue Sky application or other information or other documents executed by the Company filed in any state or other jurisdiction
to qualify any or all of the Shares under the securities laws thereof (any such application, document or information being hereinafter
referred to as a “Blue Sky Application”) or arise out of or are based upon any omission or alleged omission to state
therein a material fact required to be stated therein or necessary to make the statements therein not misleading; provided, however,
that such indemnity shall not inure to the benefit of any Underwriter (or any person controlling such Underwriter) on account of
any losses, claims, damages or liabilities arising from the sale of the Shares to any person by such Underwriter if such untrue
statement or omission or alleged untrue statement or omission was made in such preliminary prospectus, the Registration Statement,
the Prospectus, the Statutory Prospectus, any Issuer Free Writing Prospectus or such amendment or supplement thereto, any Written
Testing-the-Waters Communication, or in any Blue Sky Application in reliance upon and in conformity with the Underwriter Information.
This indemnity agreement will be in addition to any liability that the Company may otherwise have.
(b) Each
Underwriter, severally and not jointly, agrees to indemnify and hold harmless the Company, its directors and officers, and each
person, if any, who controls the Company within the meaning of Section 15 of the Securities Act or Section 20 of the Exchange Act,
against any losses, claims, damages or liabilities to which such party may become subject, under the Securities Act or otherwise,
insofar as such losses, claims, damages or liabilities (or actions in respect thereof) arise out of or are based upon an untrue
statement or alleged untrue statement of a material fact contained in any Preliminary Prospectus, the Registration Statement or
the Prospectus, or any amendment or supplement thereto, or arise out of or are based upon the omission or alleged omission to state
therein a material fact required to be stated therein or necessary to make the statements therein not misleading, in each case
to the extent, but only to the extent, that such untrue statement or alleged untrue statement or omission or alleged omission was
made in any Preliminary Prospectus, the Registration Statement, the Statutory Prospectus or the Prospectus or any such amendment
or supplement in reliance upon and in conformity with the Underwriter Information; provided, however, that the obligation of each
Underwriter to indemnify the Company (including any controlling person, director, officer or employee thereof) shall be limited
to the amount of the underwriting discount and commissions applicable to the Shares to be purchased by such Underwriter hereunder.
This indemnity agreement will be in addition to any liability that any Underwriter may otherwise have to the Company or any such
director, officer, employee or controlling person.
(c) Any
party that proposes to assert the right to be indemnified under this Section will, promptly after receipt of notice of commencement
of any action, suit or proceeding against such party in respect of which a claim is to be made against an indemnifying party or
parties under this Section, notify each such indemnifying party of the commencement of such action, suit or proceeding, enclosing
a copy of all papers served. No indemnification provided for in Section 5(a) or 5(b) shall be available to any party who shall
fail to give notice as provided in this Section 5(c) if the party to whom notice was not given was unaware of the proceeding to
which such notice would have related and was prejudiced by the failure to give such notice but the omission so to notify such indemnifying
party of any such action, suit or proceeding shall not relieve it from any liability that it may have to any indemnified party
for contribution or otherwise than under this Section. In case any such action, suit or proceeding shall be brought against any
indemnified party and it shall notify the indemnifying party of the commencement thereof, the indemnifying party shall be entitled
to participate in, and, to the extent that it shall wish, jointly with any other indemnifying party similarly notified, to assume
the defense thereof, with counsel reasonably satisfactory to such indemnified party, and after notice from the indemnifying party
to such indemnified party of its election so to assume the defense thereof and the approval by the indemnified party of such counsel,
the indemnifying party shall not be liable to such indemnified party for any legal or other expenses, except as provided below
and except for the reasonable costs of investigation subsequently incurred by such indemnified party in connection with the defense
thereof. The indemnified party shall have the right to employ its counsel in any such action, but the fees and expenses of such
counsel shall be at the expense of such indemnified party unless (i) the employment of counsel by such indemnified party has been
authorized in writing by the indemnifying parties, (ii) the indemnified party shall have been advised by counsel that there may
be one or more legal defenses available to it which are different from or in addition to those available to the indemnifying party
(in which case the indemnifying parties shall not have the right to direct the defense of such action on behalf of the indemnified
party) or (iii) the indemnifying parties shall not have employed counsel to assume the defense of such action within a reasonable
time after notice of the commencement thereof, in each of which cases the fees and expenses of counsel shall be at the expense
of the indemnifying parties. An indemnifying party shall not be liable for any settlement of any action, suit, and proceeding or
claim effected without its written consent, which consent shall not be unreasonably withheld or delayed.
6.
Contribution
.
In order to provide for just and equitable contribution in circumstances in which the indemnification provided for in Section 5(a)
or 5(b) is due in accordance with its terms but for any reason is unavailable to or insufficient to hold harmless an indemnified
party in respect to any losses, liabilities, claims, damages or expenses referred to therein, then each indemnifying party shall
contribute to the aggregate losses, liabilities, claims, damages and expenses (including any investigation, legal and other expenses
reasonably incurred in connection with, and any amount paid in settlement of, any action, suit or proceeding or any claims asserted,
but after deducting any contribution received by any person entitled hereunder to contribution from any person who may be liable
for contribution) incurred by such indemnified party, as incurred, in such proportion as is appropriate to reflect the relative
benefits received by the Company on the one hand and the Underwriters on the other hand from the offering of the Shares pursuant
to this Agreement or, if such allocation is not permitted by applicable law, in such proportion as is appropriate to reflect not
only the relative benefits referred to above but also the relative fault of the Company on the one hand and the Underwriters on
the other hand in connection with the statements or omissions which resulted in such losses, liabilities, claims, damages or expenses,
as well as any other relevant equitable considerations. The Company and the Underwriters agree that it would not be just and equitable
if contribution pursuant to this Section 6 were determined by pro rata allocation (even if the Underwriters were treated as
one entity for such purpose) or by any other method of allocation which does not take account of the equitable considerations referred
to above. The aggregate amount of losses, liabilities, claims, damages and expenses incurred by an indemnified party and referred
to above shall be deemed to include any legal or other expenses reasonably incurred by such indemnified party in investigating,
preparing or defending against any litigation, or any investigation or proceeding by any governmental agency or body, commenced
or threatened, or any claim whatsoever based upon any such untrue or alleged untrue statement or omission or alleged omission.
Notwithstanding the provisions of this Section 6, no Underwriter (except as may be provided in the Agreement Among Underwriters)
shall be required to contribute any amount in excess of the underwriting discounts and commissions applicable to the Shares purchased
by such Underwriter. No person guilty of fraudulent misrepresentation (within the meaning of Section 11(f) of the Securities Act)
shall be entitled to contribution from any person who was not guilty of such fraudulent misrepresentation. For purposes of this
Section 6, each person, if any, who controls an Underwriter within the meaning of Section 15 of the Securities Act or Section
20 of the Exchange Act shall have the same rights to contribution as such Underwriter, and each director of the Company, including
any person who, with his or her consent, is named in the Registration Statement as about to become a director of the Company, each
officer of the Company who signed the Registration Statement, and each person, if any, who controls the Company within the meaning
of the Section 15 of the Securities Act or Section 20 of the Exchange Act, shall have the same rights to contribution as the Company.
Any party entitled to contribution will, promptly after receipt of notice of commencement of any action, suit or proceeding against
such party in respect of which a claim for contribution may be made against another party or parties under this Section 6, notify
such party or parties from whom contribution may be sought, but the omission so to notify such party or parties from whom contribution
may be sought shall not relieve the party or parties from whom contribution may be sought from any other obligation it or they
may have hereunder or otherwise than under this Section 6. No party shall be liable for contribution with respect to any action,
suit, proceeding or claim settled without its written consent. The Underwriter’s obligations to contribute pursuant to this
Section 6 are several in proportion to their respective underwriting commitments and not joint.
7.
Termination
.
(a) This
Agreement may be terminated with respect to the Shares to be purchased on a Closing Date by the Representative by notifying the
Company at any time at or before a Closing Date in the absolute discretion of the Representative if: (i) there has occurred any
material adverse change in the securities markets or any event, act or occurrence that has materially disrupted, or in the opinion
of the Representative, will in the future materially disrupt, the securities markets or there shall be such a material adverse
change in general financial, political or economic conditions or the effect of international conditions on the financial markets
in the United States is such as to make it, in the judgment of the Representative, inadvisable or impracticable to market the Shares
or enforce contracts for the sale of the Shares; (ii) there has occurred any outbreak or material escalation of hostilities or
acts of terrorism or other calamity or crisis the effect of which on the financial markets of the United States is such as to make
it, in the judgment of the Representative, inadvisable or impracticable to market the Shares or enforce contracts for the sale
of the Shares; (iii) trading in the Shares or any securities of the Company has been suspended or materially limited by the Commission
or trading generally on the New York Stock Exchange, the NYSE American, the TASE, or the Nasdaq Stock Market has been suspended
or materially limited, or minimum or maximum ranges for prices for securities shall have been fixed, or maximum ranges for prices
for securities have been required, by any of said exchanges or by such system or by order of the Commission, FINRA, or any other
governmental or regulatory authority; (iv) a banking moratorium has been declared by any state or federal authority; or (v) in
the judgment of the Representative, there has been, since the time of execution of this Agreement or since the respective dates
as of which information is given in the Prospectus, any material adverse change in the assets, properties, condition, financial
or otherwise, or in the results of operations, business affairs or business prospects of the Company and its subsidiaries considered
as a whole, whether or not arising in the ordinary course of business.
(b) If
this Agreement is terminated pursuant to any of its provisions, the Company shall not be under any liability to any Underwriter,
and no Underwriter shall be under any liability to the Company, except that (y) if this Agreement is terminated by the Representative
or the Underwriters because of any failure, refusal or inability on the part of the Company to comply with the terms or to fulfill
any of the conditions of this Agreement, the Company will reimburse the Underwriters for all out-of-pocket expenses (including
the reasonable fees and disbursements of their counsel) incurred by them in connection with the proposed purchase and sale of the
Shares or in contemplation of performing their obligations hereunder and (z) no Underwriter who shall have failed or refused to
purchase the Shares agreed to be purchased by it under this Agreement, without some reason sufficient hereunder to justify cancellation
or termination of its obligations under this Agreement, shall be relieved of liability to the Company or to the other Underwriters
for damages occasioned by its failure or refusal.
8.
Substitution
of Underwriters
. If any Underwriter shall default in its obligation to purchase on any Closing Date the Shares agreed to be
purchased hereunder on such Closing Date, the Representative shall have the right, within 36 hours thereafter, to make arrangements
for one or more of the non-defaulting Underwriters, or any other underwriters, to purchase such Shares on the terms contained
herein. If, however, the Representative shall not have completed such arrangements within such 36-hour period, then the Company
shall be entitled to a further period of thirty-six hours within which to procure another party or other parties satisfactory
to the Underwriters to purchase such Shares on such terms. If, after giving effect to any arrangements for the purchase of the
Shares of a defaulting Underwriter or Underwriters by the Representative and the Company as provided above, the aggregate number
of Shares which remains unpurchased on such Closing Date does not exceed one-eleventh of the aggregate number of all the Shares
that all the Underwriters are obligated to purchase on such date, then the Company shall have the right to require each non-defaulting
Underwriter to purchase the number of Shares which such Underwriter agreed to purchase hereunder at such date and, in addition,
to require each non-defaulting Underwriter to purchase its pro rata share (based on the number of Shares which such Underwriter
agreed to purchase hereunder) of the Shares of such defaulting Underwriter or Underwriters for which such arrangements have not
been made; but nothing herein shall relieve a defaulting Underwriter from liability for its default. In any such case, either
the Representative or the Company shall have the right to postpone the applicable Closing Date for a period of not more than seven
business days in order to effect any necessary changes and arrangements (including any necessary amendments or supplements to
the Registration Statement or Prospectus or any other documents), and the Company agrees to file promptly any amendments to the
Registration Statement or the Prospectus which in the opinion of the Company and the Underwriters and their respective counsels
may thereby be made necessary.
If, after giving effect to
any arrangements for the purchase of the Shares of a defaulting Underwriter or Underwriters by the Representative and the Company
as provided above, the aggregate number of such Shares which remains unpurchased exceeds 10% of the aggregate number of all the
Shares to be purchased at such date, then this Agreement, or, with respect to a Closing Date which occurs after the First Closing
Date, the obligations of the Underwriters to purchase and of the Company to sell the Option Shares to be purchased and sold on
such date, shall terminate, without liability on the part of any non-defaulting Underwriter to the Company, and without liability
on the part of the Company, except as provided in Sections 4(b), 5, 6 and 7. The provisions of this Section 8 shall not in any
way affect the liability of any defaulting Underwriter to the Company or the non-defaulting Underwriters arising out of such default.
The term “Underwriter” as used in this Agreement shall include any person substituted under this Section 8 with like
effect as if such person had originally been a party to this Agreement with respect to such Shares.
Nothing contained herein
shall relieve a defaulting Underwriter of any liability it may have to the Company or any non-defaulting Underwriter for damages
caused by its default.
9.
Persons
Entitled to Benefit of Agreement
. This Agreement has been and is made for the benefit of and binding upon the Underwriters,
the Company, and their respective successors. This Agreement and the terms and provisions hereof are for the sole benefit of only
those persons, except that (a) the representations, warranties, indemnities and agreements of the Company contained in this Agreement
shall also be deemed to be for the benefit of the directors, officers and employees of the Underwriters and each person or persons,
if any, who control any Underwriter within the meaning of Section 15 of the Securities Act, and (b) the indemnity agreement
of the Underwriters contained in Section 5 of this Agreement shall be deemed to be for the benefit of the directors of the
Company, the officers of the Company who have signed the Registration Statement and any person controlling the Company within the
meaning of Section 15 of the Securities Act, but only to the extent specifically described herein. Nothing in this Agreement
is intended or shall be construed to give any person, other than the persons referred to in this Section 9, any legal or equitable
right, remedy or claim under or in respect of this Agreement or any provision contained herein.
10.
Miscellaneous
.
The respective agreements, representations, warranties, indemnities and other statements of the Company and the several Underwriters,
as set forth in this Agreement or made by or on behalf of them pursuant to this Agreement, shall remain in full force and effect,
regardless of any investigation (or any statement as to the results thereof) made by or on behalf of any Underwriter or the Company
or any of their respective officers, directors or controlling persons referred to in Sections 5 and 6 hereof, and shall survive
delivery of and payment for the Shares. In addition, the provisions of Sections 4(b), 5, 6 and 7 shall survive the termination
or cancellation of this Agreement.
All notices and communications
hereunder shall be in writing and mailed or delivered or by telephone or facsimile if subsequently confirmed in writing, (a) if
to the Representative, c/o Oppenheimer & Co. Inc., 85 Broad Street, New York, New York 10004 Attention: Equity Capital Markets,
with a copy to Oppenheimer & Co. Inc., 85 Broad Street, New York, New York 10004 Attention: General Counsel
, with
a copy to the Legal Department;
and to Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C., 666 Third Avenue, New York,
New York 10017, Attention: Ivan K. Blumenthal, Esq., Facsimile: 212-983-3115, and (b) if to the Company, to its agent for service
as such agent’s address appears on the cover page of the Registration Statement, with a copy to Mayer Brown LLP, 1221 Avenue
of the Americas, New York, New York 10020, Attention: Anna T. Pinedo.
This Agreement shall
be governed by and construed in accordance with the internal laws of the State of New York applicable to agreements made and to
be performed in such state.
Any legal suit, action or proceeding arising out of or based upon this Agreement or the transactions
contemplated hereby (“Related Proceedings”) may be instituted in the federal courts of the United States of America
located in the Borough of Manhattan in the City of New York or the courts of the State of New York in each case located in the
Borough of Manhattan in the City of New York (collectively, the “Specified Courts”), and each party irrevocably submits
to the exclusive jurisdiction (except for proceedings instituted in regard to the enforcement of a judgment of any such court (a
“Related Judgment”), as to which such jurisdiction is non-exclusive) of such courts in any such suit, action or proceeding.
Service of any process, summons, notice or document by mail to such party’s address set forth above shall be effective service
of process for any suit, action or other proceeding brought in any such court. The parties irrevocably and unconditionally waive
any objection to the laying of venue of any suit, action or other proceeding in the Specified Courts and irrevocably and unconditionally
waive and agree not to plead or claim in any such court that any such suit, action or other proceeding brought in any such court
has been brought in an inconvenient forum. The Company has irrevocably appointed Anchiano Therapeutics, Inc., which currently maintains
an office at One Kendall Square, Building 600, Suite 6-106, Cambridge, Massachusetts 02139, United States of America, as its agent
to receive service of process or other legal summons for purposes of any such suit, action or proceeding that may be instituted
in any state or federal court in the Borough of Manhattan in the City of New York, United States of America.
With respect to any Related
Proceeding, each party irrevocably waives, to the fullest extent permitted by applicable law, all immunity (whether on the basis
of sovereignty or otherwise) from jurisdiction, service of process, attachment (both before and after judgment) and execution to
which it might otherwise be entitled in the Specified Courts, and with respect to any Related Judgment, each party waives any such
immunity in the Specified Courts or any other court of competent jurisdiction, and will not raise or claim or cause to be pleaded
any such immunity at or in respect of any such Related Proceeding or Related Judgment, including, without limitation, any immunity
pursuant to the United States Foreign Sovereign Immunities Act of 1976, as amended.
The obligations of the
Company pursuant to this Agreement in respect of any sum due to the Underwriters shall, notwithstanding any judgment in a currency
other than United States dollars, not be discharged until the first business day, following receipt by the Underwriters of any
sum adjudged to be so due in such other currency, on which the Underwriters may in accordance with normal banking procedures purchase
United States dollars with such other currency. If the United States dollars so purchased are less than the sum originally due
to the Underwriters in United States dollars hereunder, the Company agrees as a separate obligation and notwithstanding any such
judgment, to indemnify the Underwriters against such loss. If the United States dollars so purchased are greater than the sum originally
due to the Underwriters hereunder, the Underwriters agree to pay to the Company an amount equal to the excess of the dollars so
purchased over the sum originally due to the Underwriters hereunder.
All payments made or deemed
to be made by the Company under this Agreement, if any, will be made without withholding or deduction for or on account of any
present or future taxes, duties, assessments or governmental charges of whatever nature (other than taxes on net income) imposed
or levied by or on behalf of the State of Israel, any other jurisdiction from or through which payment is made, or, in each case,
any political subdivision or any taxing authority thereof or therein unless the Company is or becomes required by law to withhold
or deduct such taxes, duties, assessments or other governmental charges. In such event, the Company will pay such additional amounts
as will result, after such withholding or deduction, in the receipt by each Underwriter, its officers and employees, and each person
controlling any Underwriter, as the case may be, of the amounts that would otherwise have been receivable in respect thereof.
[Remainder of Page Intentionally
Left Blank. Signature Page Follows.]
This Agreement may be signed
in any number of counterparts, each of which shall be an original, with the same effect as if the signatures thereto and hereto
were upon the same instrument.
Please confirm that the foregoing
correctly sets forth the agreement among us.
|
|
Very truly yours,
|
|
|
|
|
|
ANCHIANO THERAPEUTICS LTD.
|
|
|
|
|
|
By
|
/s/ Jonathan Burgin
|
|
|
|
Title: COO & CFO
|
Confirmed:
Acting severally on behalf of itself and
as the Representative of the several Underwriters
named in Schedule I annexed hereto.
|
OPPENHEIMER & CO. INC.
|
|
|
|
|
|
By
|
/s/ Stephanie Cruz
|
|
|
Title:
|
Managing Director
|
|
[Signature Page to Underwriting Agreement]
SCHEDULE I
|
Name
|
|
Number of
Firm
Shares to
Be
Purchased
|
|
|
|
|
|
|
|
Oppenheimer & Co. Inc.
|
|
|
1,763,696
|
|
|
Ladenburg Thalmann & Co. Inc.
|
|
|
755,870
|
|
|
LifeSci Capital LLC
|
|
|
132,608
|
|
|
|
|
|
|
|
|
Total
|
|
|
2,652,174
|
|
SCHEDULE II
Lock-up Signatories
Directors & Officers
Ruth Alon
Jonathan Burgin
Robert Connelly
Sean Daly
Dr. Frank G. Haluska
Reginald Hardy
Dr. Stephen Hoffman
Dr. Lawrence Howard
Dr. Ron Knickerbocker
Isaac Kohlberg
Efrat Makov
Dr. Michal Gilon Ohev-Zion
Dennison Veru
David Kerstein
Shareholders
Clal Biotechnology Industries Ltd.
Shavit Capital Funds
Edgewater Partner Holdings Ltd.
Palisade Medical Equity I, LP
SCHEDULE III
Issuer Free Writing Prospectuses
None
SCHEDULE IV
Testing-the-Waters Communications
None
Exhibit A
[Form of Lock-Up Agreement]
__________, 2018
Oppenheimer & Co. Inc.
as Representative of the Several Underwriters
c/o Oppenheimer & Co. Inc.
85 Broad Street
New York, New York 10004
|
|
Re:
|
Initial Public Offering of Anchiano Therapeutics Ltd.
|
Ladies and Gentlemen:
The undersigned understands
that you and certain other firms (the “
Underwriters
”) propose to enter into an Underwriting Agreement (the “
Underwriting
Agreement
”) providing for the purchase by the Underwriters of American Depositary Shares (the “
ADSs
”),
each representing ordinary shares, no par value (the “
Ordinary Shares
”), of Anchiano Therapeutics Ltd., a limited
company organized under the laws of the State of Israel (the “
Company
”), and that the Underwriters propose to
reoffer the ADSs to the public (the “
Offering
”), as described in and contemplated by the registration statement
of the Company on Form F-1, File No. 333-[●] (the “
Registration Statement
”).
In consideration of the
Underwriters’ agreement to enter into the Underwriting Agreement and to proceed with the Offering of the ADSs, and for other
good and valuable consideration, receipt of which is hereby acknowledged, the undersigned hereby agrees that, without the prior
written consent of the Representative, the undersigned will not, during the period ending 180 days after the date on which the
Underwriting Agreement is entered into (the “
Lock-Up Period
”), directly or indirectly (1) offer, pledge, assign,
encumber, announce the intention to sell, sell, contract to sell, sell any option or contract to purchase, purchase any option
or contract to sell, grant any option, right or warrant to purchase, or otherwise transfer or dispose of (collectively, a “
Disposition
”),
any Ordinary Shares or ADSs or any securities convertible into or exercisable or exchangeable for Ordinary Shares or ADSs (“
Related
Securities
”), owned either of record or beneficially (as defined in the Securities Exchange Act of 1934, as amended (the
“
Exchange Act
”)) by the undersigned on the date hereof or hereafter acquired, or (2) enter into any swap or
other agreement that transfers, in whole or in part, any of the economic consequences of ownership of any Ordinary Shares or ADSs,
whether any such transaction described in clause (1) or (2) above is to be settled by delivery of Ordinary Shares or ADSs or such
other securities, in cash or otherwise, or publicly announce an intention to do any of the foregoing. In addition, the undersigned
agrees that, without the prior written consent of the Representative, the undersigned will not, during the Lock-Up Period, make
any demand for, or exercise any right with respect to, the registration of any Ordinary Shares or ADSs or any Related Securities.
The foregoing shall not apply to (a) transfers of Ordinary Shares, ADSs or any Related Securities (i) as a bona fide gift or for
bona fide estate planning purposes, (ii) upon death or by will, testamentary document or intestate succession, (iii) to an immediate
family member of the undersigned or to any trust for the direct or indirect benefit of the undersigned or the immediate family
of the undersigned (for purposes of this agreement, “immediate family” shall mean any relationship by blood, current
or former marriage or adoption, not more remote than first cousin), (iv) not involving a change in beneficial ownership, (v) if
the undersigned is a trust, to any beneficiary of the undersigned or the estate of any such beneficiary, (vi) any investment fund
or other entity controlled or managed by the undersigned, or (vii) by operation of law or by an order of a court or regulatory
agency; (b) if the undersigned is a corporation, partnership, limited liability company or other entity, (i) distributions of Ordinary
Shares, ADSs or any Related Securities to stockholders, direct or indirect affiliates (within the meaning set forth in Rule 405
under the Securities Act of 1933, as amended (the “
Securities Act
”)), current or former partners (general or
limited), members or managers of the undersigned, as applicable, or to the estates of any such stockholders, affiliates, partners,
members or managers or
(ii) sales or transfers of Ordinary Shares, ADSs or Related Securities
to another such entity that is a direct or indirect affiliate of the undersigned or to any investment fund or other entity controlled
or managed by, or under common control or management with, the undersigned
; (c) sales under any existing Rule 10b5-1 plan
or the establishment of a trading plan pursuant to Rule 10b5-1 under the Exchange Act for the transfer of Ordinary Shares or ADSs,
provided that (i) such plan does not provide for the transfer of Ordinary Shares or ADSs during the Lock-Up Period and (ii) no
public announcement or filing under the Exchange Act regarding the establishment of such plan shall be required or shall be voluntarily
made by or on behalf of the undersigned or the Company during the Lock-Up Period; or (d) transfers of Ordinary Shares, ADSs or
any Related Securities made with the prior written consent of the Representative on behalf of the Underwriters,
provided,
in the case of clauses (a)-(b)(i), that such transfer shall not involve a disposition for value and the transferee agrees in writing
with the Representative and the Company to be bound by the terms hereof.
Notwithstanding the restrictions
imposed by this agreement, the undersigned may, without the prior written consent of the Representative, transfer Ordinary Shares,
ADSs or Related Securities (a) as forfeitures to satisfy tax withholding and remittance obligations of the undersigned in connection
with the vesting or exercise of equity awards by the undersigned pursuant to the Company’s equity incentive plans existing
as of the date of the prospectus relating to the Offering in the form included in the Registration Statement or, if the prospectus
included in the Registration Statement omits certain information in reliance upon Rule 430A under the Securities Act and such information
is thereafter included in a prospectus filed with the Securities and Exchange Commission pursuant to Rule 424(b) under the Securities
Act or as part of a post-effective amendment to the Registration Statement, the prospectus as so filed (the “
Prospectus
”)
and described in the Prospectus, (b) pursuant to a net exercise or cashless exercise by the undersigned of outstanding equity awards
pursuant to the Company’s equity incentive plans existing as of the date of the Prospectus and described in the Prospectus,
provided
that any Ordinary Shares acquired upon the net exercise or cashless exercise of equity awards described in this
clause (b) shall be subject to the restrictions set forth in this letter agreement, or (c) pursuant to a bona fide third-party
tender offer for all outstanding shares of the Company, merger, consolidation or other similar transaction made to all holders
of the Company’s securities involving a change of control of the Company (including, without limitation, the entering into
any lock-up, voting or similar agreement pursuant to which the undersigned may agree to transfer, sell, tender or otherwise dispose
of Ordinary Shares or ADSs or other such securities in connection with such transaction, or vote any Ordinary Shares or ADSs or
other such securities in favor of any transaction), provided that in the event that such tender offer, merger, consolidation or
other such transaction is not completed, such securities held by the undersigned shall remain subject to the provisions of this
letter agreement,
provided
, that the restrictions set forth in this letter agreement shall apply to any of the undersigned’s
Ordinary Shares, ADSs or Related Securities issued upon such conversion or exercise;
provided further
, that, in the case
of a transfer pursuant to clause (a) or (b) above, if the undersigned is required to make a filing under the Exchange Act reporting
a reduction in beneficial ownership of Ordinary Shares or ADSs during the Lock-up Period, the undersigned shall include a statement
in such report to the effect that the purpose of such transfer was to cover tax obligations of the undersigned in connection with
such exercise.
Notwithstanding the agreement
not to make any Disposition during the Lock-Up Period, you have agreed that the foregoing restrictions shall not apply to:
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(1)
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any grant of options pursuant to the Company’s stock
option plans prior to the date of the Prospectus; or
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(2)
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any exercise by the undersigned of any options pursuant
to the Company’s stock option plans or warrant to acquire Ordinary Shares, provided that the undersigned does not transfer
the Ordinary Shares acquired on such exercise during the Lock-up Period, unless otherwise permitted pursuant to the terms of this
agreement.
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In furtherance of the foregoing,
the Company, and any duly appointed transfer agent for the registration or transfer of the securities described herein, are hereby
authorized to decline to make any transfer of securities if such transfer would constitute a violation or breach of this agreement.
The undersigned hereby
represents and warrants that the undersigned has full power and authority to enter into this agreement. All authority herein conferred
or agreed to be conferred and any obligations of the undersigned shall be binding upon the successors, assigns, heirs or personal
representatives of the undersigned.
The undersigned understands
that this agreement shall terminate and the undersigned shall be released from all obligations hereunder upon the earliest to occur,
if any, of (a) the Company informing the undersigned that its board of directors has determined not to proceed with the Offering
or the Registration Statement filed with the Securities and Exchange Commission in connection with the Offering has been withdrawn,
(b) the Underwriting Agreement (other than the provisions thereof which survive termination) is terminated prior to payment for
and delivery of the ADSs to be sold thereunder (the “
Closing
”), or (c) March 31, 2019, in the event the Closing
has not occurred by such date.
The undersigned, whether
or not participating in the Offering, understands that the Representative on behalf of the Underwriters is entering into the Underwriting
Agreement and proceeding with the Offering in reliance upon this agreement.
[Signature page follows.]
This agreement shall be
governed by and construed in accordance with the laws of the State of New York, without regard to the conflict of laws principles
thereof (other than New York General Obligations Law § 5-1401).
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Very truly yours,
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[SHAREHOLDER]
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By:
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Name:
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Title:
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Exhibit A-1
[Form of Waiver of Lock-up]
[corporation]
Public Offering of Ordinary Shares
[ ], 20[ ]
[Name and Address of
Officer or Director
Requesting Waiver]
Dear Mr./Ms. [Name]:
This letter is being delivered
to you in connection with the offering by [Corporation] (the “Company”) of [ ] American Depositary Shares, each representing
[ ] ordinary shares of the Company, no par value (the “ADS”), and the lock-up agreement dated [ ], 20[ ] (the “Lock-up
Agreement”), executed by you in connection with such offering, and your request for a [waiver] [release] dated [ ], 20[ ],
with respect to [ ] ADSs (the “Securities”).
Oppenheimer & Co. Inc.
hereby agrees to [waive] [release] the transfer restrictions set forth in the Lock-up Letter, but only with respect to the Securities,
effective [ ], 20[ ][date to be 3 business days from date of letter];
provided
,
however
, that such [waiver] [release]
is conditioned on the Company announcing the impending [waiver] [release] by press release through a major news service at least
two business days before effectiveness of such [waiver] [release]. This letter will serve as notice to the Company of the impending
[waiver] [release].
Except as expressly [waived] [released] hereby,
the Lock-up Letter shall remain in full force and effect.
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Yours very truly,
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OPPENHEIMER & CO. INC.
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By:
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Name:
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Title:
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cc: [Company contact]
Exhibit A-2
[Form of Lock Up Waiver/Release
Company Press Release]
[Company]
[Date]
(“[Company]”) announced today that
Oppenheimer & Co. Inc., the [lead book-running] manager in the Company’s recent public sale of [ ] ordinary shares, is
[waiving] [releasing] a lock-up restriction with respect to [ ] American Depositary Shares, each representing [ ] ordinary shares
of the Company held by [ ], an [officer/director] of the Company. The [waiver] [release] will take effect on [ ], 20[ ], and the
related shares may be sold on or after such date.
This press release is not an offer for sale of the securities
in the United States or in any other jurisdiction where such offer is prohibited, and such securities may not be offered or sold
in the United States absent registration or an exemption from registration under the United States Securities Act of 1933, as
amended.
Exhibit 4.1
[EXECUTION COPY]
ANCHIANO THERAPEUTICS LTD.
AND
THE BANK OF NEW YORK MELLON
As Depositary
AND
OWNERS AND HOLDERS OF AMERICAN DEPOSITARY
SHARES
Deposit Agreement
Dated as of February 14, 2019
TABLE OF CONTENTS
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ARTICLE 1.
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DEFINITIONS
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1
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SECTION 1.1.
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American Depositary Shares
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1
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SECTION 1.2.
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Commission
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2
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SECTION 1.3.
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Company
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2
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SECTION 1.4.
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Custodian
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2
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SECTION 1.5.
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Delisting Event
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2
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SECTION 1.6.
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Deliver; Surrender
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2
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SECTION 1.7.
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Deposit Agreement
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3
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SECTION 1.8.
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Depositary; Depositary’s Office
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3
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SECTION 1.9.
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Deposited Securities
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3
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SECTION 1.10.
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Disseminate
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3
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SECTION 1.11.
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Dollars
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4
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SECTION 1.12.
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DTC
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4
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SECTION 1.13.
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Foreign Registrar
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4
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SECTION 1.14.
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Holder
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4
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SECTION 1.15.
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Insolvency Event
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4
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SECTION 1.16.
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Owner
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4
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SECTION 1.17.
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Receipts
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5
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SECTION 1.18.
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Registrar
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5
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SECTION 1.19.
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Replacement
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5
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SECTION 1.20.
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Restricted Securities
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5
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SECTION 1.21.
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Securities Act of 1933
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5
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SECTION 1.22.
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Shares
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5
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SECTION 1.23.
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SWIFT
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6
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SECTION 1.24.
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Termination Option Event
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6
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ARTICLE 2.
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FORM OF RECEIPTS, DEPOSIT OF SHARES, DELIVERY, TRANSFER AND SURRENDER OF AMERICAN DEPOSITARY SHARES
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6
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SECTION 2.1.
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Form of Receipts; Registration and Transferability of American Depositary Shares
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6
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SECTION 2.2.
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Deposit of Shares
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7
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SECTION 2.3.
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Delivery of American Depositary Shares
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8
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SECTION 2.4.
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Registration of Transfer of American Depositary Shares; Combination and Split-up of Receipts; Interchange of Certificated and Uncertificated American Depositary Shares
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8
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SECTION 2.5.
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Surrender of American Depositary Shares and Withdrawal of Deposited Securities
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9
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SECTION 2.6.
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Limitations on Delivery, Transfer and Surrender of American Depositary Shares
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10
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SECTION 2.7.
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Lost Receipts, etc.
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11
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SECTION 2.8.
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Cancellation and Destruction of Surrendered Receipts
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12
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SECTION 2.9.
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DTC Direct Registration System and Profile Modification System
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12
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ARTICLE 3.
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CERTAIN OBLIGATIONS OF OWNERS AND HOLDERS OF AMERICAN DEPOSITARY SHARES
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12
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SECTION 3.1.
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Filing Proofs, Certificates and Other Information
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12
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SECTION 3.2.
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Liability of Owner for Taxes
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13
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SECTION 3.3.
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Warranties on Deposit of Shares
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13
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SECTION 3.4.
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Disclosure of Interests
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14
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ARTICLE 4.
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THE DEPOSITED SECURITIES
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14
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SECTION 4.1.
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Cash Distributions
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14
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SECTION 4.2.
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Distributions Other Than Cash, Shares or Rights
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15
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SECTION 4.3.
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Distributions in Shares
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16
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SECTION 4.4.
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Rights
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17
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SECTION 4.5.
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Conversion of Foreign Currency
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18
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SECTION 4.6.
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Fixing of Record Date
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19
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SECTION 4.7.
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Voting of Deposited Shares
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20
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SECTION 4.8.
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Tender and Exchange Offers; Redemption, Replacement or Cancellation of Deposited Securities
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20
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SECTION 4.9.
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Reports
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22
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SECTION 4.10.
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Lists of Owners
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22
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SECTION 4.11.
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Withholding
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22
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ARTICLE 5.
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THE DEPOSITARY, THE CUSTODIANS AND THE COMPANY
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23
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SECTION 5.1.
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Maintenance of Office and Transfer Books by the Depositary
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23
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SECTION 5.2.
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Prevention or Delay of Performance by the Company or the Depositary
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24
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SECTION 5.3.
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Obligations of the Depositary and the Company
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25
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SECTION 5.4.
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Resignation and Removal of the Depositary
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26
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SECTION 5.5.
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The Custodians
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27
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SECTION 5.6.
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Notices and Reports
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27
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SECTION 5.7.
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Distribution of Additional Shares, Rights, etc.
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28
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SECTION 5.8.
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Indemnification
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29
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SECTION 5.9.
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Charges of Depositary
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29
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SECTION 5.10.
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Retention of Depositary Documents
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30
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SECTION 5.11.
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Exclusivity
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31
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SECTION 5.12.
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Information for Regulatory Compliance
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31
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ARTICLE 6.
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AMENDMENT AND TERMINATION
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31
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SECTION 6.1.
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Amendment
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31
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SECTION 6.2.
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Termination
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32
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ARTICLE 7.
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MISCELLANEOUS
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33
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SECTION 7.1.
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Counterparts; Signatures
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33
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SECTION 7.2.
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No Third Party Beneficiaries
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33
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SECTION 7.3.
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Severability
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33
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SECTION 7.4.
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Owners and Holders as Parties; Binding Effect
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34
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SECTION 7.5.
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Notices
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34
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SECTION 7.6.
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Appointment of Agent for Service of Process; Submission to Jurisdiction; Jury Trial Waiver
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35
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SECTION 7.7.
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Waiver of Immunities
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36
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SECTION 7.8.
|
Governing Law
|
36
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DEPOSIT AGREEMENT
DEPOSIT AGREEMENT dated
as of February 14, 2019 among ANCHIANO THERAPEUTICS LTD., a company incorporated under the laws of Israel (herein called the Company),
THE BANK OF NEW YORK MELLON, a New York banking corporation (herein called the Depositary), and all Owners and Holders (each as
hereinafter defined) from time to time of American Depositary Shares issued hereunder.
WITNESSETH:
WHEREAS, the Company
desires to provide, as set forth in this Deposit Agreement, for the deposit of Shares (as hereinafter defined) of the Company from
time to time with the Depositary or with the Custodian (as hereinafter defined) under this Deposit Agreement, for the creation
of American Depositary Shares representing the Shares so deposited and for the execution and delivery of American Depositary Receipts
evidencing the American Depositary Shares; and
WHEREAS, the American
Depositary Receipts are to be substantially in the form of Exhibit A annexed to this Deposit Agreement, with appropriate insertions,
modifications and omissions, as set forth in this Deposit Agreement;
NOW, THEREFORE, in consideration
of the premises, it is agreed by and between the parties hereto as follows:
ARTICLE 1. DEFINITIONS
The following definitions
shall for all purposes, unless otherwise clearly indicated, apply to the respective terms used in this Deposit Agreement:
SECTION 1.1.
American
Depositary Shares.
The term “
American
Depositary Shares
” shall mean the securities created under this Deposit Agreement representing rights with respect to
the Deposited Securities. American Depositary Shares may be certificated securities evidenced by Receipts or uncertificated securities.
The form of Receipt annexed as Exhibit A to this Deposit Agreement shall be the prospectus required for an offer under the Securities
Act of 1933 of both certificated and uncertificated American Depositary Shares. Except for those provisions of this Deposit Agreement
that refer specifically to Receipts, all the provisions of this Deposit Agreement shall apply to both certificated and uncertificated
American Depositary Shares.
Each American Depositary
Share shall represent the number of Shares specified in Exhibit A to this Deposit Agreement,
except that
, if there is a
distribution upon Deposited Securities covered by Section 4.3, a change in Deposited Securities covered by Section 4.8 with respect
to which additional American Depositary Shares are not delivered or a sale of Deposited Securities under Section 3.2 or 4.8, each
American Depositary Share shall thereafter represent the amount of Shares or other Deposited Securities that are then on deposit
per American Depositary Share after giving effect to that distribution, change or sale.
SECTION 1.2.
Commission.
The term “
Commission
”
shall mean the Securities and Exchange Commission of the United States or any successor governmental agency in the United States.
SECTION 1.3.
Company.
The term “
Company
”
shall mean Anchiano Therapeutics Ltd., a company incorporated under the laws of Israel, and its successors.
SECTION 1.4.
Custodian.
The term “
Custodian
”
shall mean Bank Leumi and Bank Hapoalim, as custodian for the Depositary in Israel for the purposes of this Deposit Agreement,
and any other firm or corporation the Depositary appoints under Section 5.5 as a substitute or additional custodian under this
Deposit Agreement, and shall also mean all of them collectively.
SECTION 1.5.
Delisting
Event.
A “
Delisting
Event
” occurs if the American Depositary Shares are delisted from a securities exchange on which the American Depositary
Shares were listed and the American Depositary Shares have not, within a reasonable period thereafter, been accepted for listing
on any other securities exchange.
SECTION 1.6.
Deliver;
Surrender.
(a) The
term “
deliver
”, or its noun form, when used with respect to Shares or other Deposited Securities, shall mean
(i) book-entry transfer of those Shares or other Deposited Securities to an account maintained by an institution authorized under
applicable law to effect transfers of such securities designated by the person entitled to that delivery or (ii) physical transfer
of certificates evidencing those Shares or other Deposited Securities registered in the name of, or duly endorsed or accompanied
by proper instruments of transfer to, the person entitled to that delivery.
(b) The
term “
deliver
”, or its noun form, when used with respect to American Depositary Shares, shall mean (i) registration
of those American Depositary Shares in the name of DTC or its nominee and book-entry transfer of those American Depositary Shares
to an account at DTC designated by the person entitled to that delivery, (ii) registration of those American Depositary Shares
not evidenced by a Receipt on the books of the Depositary in the name requested by the person entitled to that delivery and mailing
to that person of a statement confirming that registration or (iii) if requested by the person entitled to that delivery, execution
and delivery at the Depositary’s Office to the person entitled to that delivery of one or more Receipts evidencing those
American Depositary Shares registered in the name requested by that person.
(c) The
term “
surrender
”, when used with respect to American Depositary Shares, shall mean (i) one or more book-entry
transfers of American Depositary Shares to the DTC account of the Depositary, (ii) delivery to the Depositary at its Office of
an instruction to surrender American Depositary Shares not evidenced by a Receipt or (iii) surrender to the Depositary at its Office
of one or more Receipts evidencing American Depositary Shares.
SECTION 1.7.
Deposit
Agreement.
The term “
Deposit
Agreement
” shall mean this Deposit Agreement, as it may be amended from time to time in accordance with the provisions
of this Deposit Agreement.
SECTION 1.8.
Depositary;
Depositary’s Office.
The term “
Depositary
”
shall mean The Bank of New York Mellon, a New York banking corporation, and any successor as depositary under this Deposit Agreement.
The term “
Office
”, when used with respect to the Depositary, shall mean the office at which its depositary receipts
business is administered, which, at the date of this Deposit Agreement, is located at 240 Greenwich Street, New York, New York
10286.
SECTION 1.9.
Deposited
Securities.
The term “
Deposited
Securities
” as of any time shall mean Shares at such time deposited or deemed to be deposited under this Deposit Agreement,
including without limitation, Shares that have not been successfully delivered upon surrender of American Depositary Shares, and
any and all other securities, property and cash received by the Depositary or the Custodian in respect of Deposited Securities
and at that time held under this Deposit Agreement.
SECTION 1.10.
Disseminate.
The term “
Disseminate
,”
when referring to a notice or other information to be sent by the Depositary to Owners, shall mean (i) sending that information
to Owners in paper form by mail or another means or (ii) with the consent of Owners, another procedure that has the effect of making
the information available to Owners, which may include (A) sending the information by electronic mail or electronic messaging or
(B) sending in paper form or by electronic mail or messaging a statement that the information is available and may be accessed
by the Owner on an Internet website and that it will be sent in paper form upon request by the Owner, when that information is
so available and is sent in paper form as promptly as practicable upon request.
SECTION 1.11.
Dollars.
The term “
Dollars
”
shall mean United States dollars.
SECTION 1.12.
DTC.
The term “
DTC
”
shall mean The Depository Trust Company or its successor.
SECTION 1.13.
Foreign
Registrar.
The term “
Foreign
Registrar
” shall mean the entity that carries out the duties of registrar for the Shares and any other agent of the Company
for the transfer and registration of Shares, including, without limitation, any securities depository for the Shares.
SECTION 1.14.
Holder.
The term “
Holder
”
shall mean any person holding a Receipt or a security entitlement or other interest in American Depositary Shares, whether for
its own account or for the account of another person, but that is not the Owner of that Receipt or those American Depositary Shares.
SECTION 1.15.
Insolvency
Event.
An “
Insolvency
Event
” occurs if the Company institutes proceedings to be adjudicated as bankrupt or insolvent, consents to the institution
of bankruptcy or insolvency proceedings against it, files a petition or answer or consent seeking reorganization or relief under
any applicable law in respect of bankruptcy or insolvency, consents to the filing of any petition of that kind or to the appointment
of a receiver, liquidator, assignee, trustee, custodian or sequestrator (or other similar official) of it or any substantial part
of its property or makes an assignment for the benefit of creditors, or if the Company admits its inability to pay its debts as
they become due in the ordinary course of business.
SECTION 1.16.
Owner.
The term “
Owner
”
shall mean the person in whose name American Depositary Shares are registered on the books of the Depositary maintained for that
purpose.
SECTION 1.17.
Receipts.
The term “
Receipts
”
shall mean the American Depositary Receipts issued under this Deposit Agreement evidencing certificated American Depositary Shares,
as the same may be amended from time to time in accordance with the provisions of this Deposit Agreement.
SECTION 1.18.
Registrar.
The term “
Registrar
”
shall mean any corporation or other entity that is appointed by the Depositary to register American Depositary Shares and transfers
of American Depositary Shares as provided in this Deposit Agreement.
SECTION 1.19.
Replacement.
The term “
Replacement
”
shall have the meaning assigned to it in Section 4.8.
SECTION 1.20.
Restricted
Securities.
The term “
Restricted
Securities
” shall mean Shares that (i) are “restricted securities,” as defined in Rule 144 under the Securities
Act of 1933, except for Shares that could be resold in reliance on Rule 144 without any conditions, (ii) are control shares, meaning
that such shares are beneficially owned by an officer, director (or person performing similar functions) or other affiliate of
the Company, (iii) otherwise would require registration under the Securities Act of 1933 in connection with the public offer thereof
in the United States or (iv) are subject to other restrictions on sale or deposit under the laws of Israel, a shareholder agreement
or the articles of association or similar document of the Company.
SECTION 1.21.
Securities
Act of 1933.
The term “
Securities
Act of 1933
” shall mean the United States Securities Act of 1933, as from time to time amended.
SECTION 1.22.
Shares.
The term “
Shares
”
shall mean ordinary shares of the Company that are validly issued and outstanding, fully paid and nonassessable and that were not
issued in violation of any pre-emptive or similar rights of the holders of outstanding securities of the Company;
provided
,
however
, that, if there shall occur any change in nominal or par value, a split-up or consolidation or any other reclassification
or, upon the occurrence of an event described in Section 4.8, an exchange or conversion in respect of the Shares of the Company,
the term “Shares” shall thereafter also mean the successor securities resulting from such change in nominal value,
split-up or consolidation or such other reclassification or such exchange or conversion.
SECTION 1.23.
SWIFT.
The term “
SWIFT
”
shall mean the financial messaging network operated by the Society for Worldwide Interbank Financial Telecommunication, or its
successor.
SECTION 1.24.
Termination
Option Event.
The term “
Termination
Option Event
” shall mean an event of a kind defined as such in Section 4.1, 4.2 or 4.8.
ARTICLE
2. FORM OF RECEIPTS, DEPOSIT OF SHARES, DELIVERY, TRANSFER AND SURRENDER
OF AMERICAN DEPOSITARY SHARES
SECTION 2.1.
Form
of Receipts; Registration and Transferability of American Depositary Shares.
Definitive Receipts shall
be substantially in the form set forth in Exhibit A to this Deposit Agreement, with appropriate insertions, modifications and omissions,
as permitted under this Deposit Agreement. No Receipt shall be entitled to any benefits under this Deposit Agreement or be valid
or obligatory for any purpose, unless that Receipt has been (i) executed by the Depositary by the manual signature of a duly authorized
officer of the Depositary or (ii) executed by the facsimile signature of a duly authorized officer of the Depositary and countersigned
by the manual signature of a duly authorized signatory of the Depositary or the Registrar or a co-registrar. The Depositary shall
maintain books on which (x) each Receipt so executed and delivered as provided in this Deposit Agreement and each transfer of that
Receipt and (y) all American Depositary Shares delivered as provided in this Deposit Agreement and all registrations of transfer
of American Depositary Shares, shall be registered. A Receipt bearing the facsimile signature of a person that was at any time
a proper officer of the Depositary shall, subject to the other provisions of this paragraph, bind the Depositary, even if that
person was not a proper officer of the Depositary on the date of issuance of that Receipt.
The Receipts and statements
confirming registration of American Depositary Shares may have incorporated in or attached to them such legends or recitals or
modifications not inconsistent with the provisions of this Deposit Agreement as may reasonably be required by the Company or the
Depositary, or required to comply with any applicable law or regulations thereunder or with the rules and regulations of any securities
exchange upon which American Depositary Shares may be listed or to conform with any usage with respect thereto, or to indicate
any special limitations or restrictions to which any particular Receipts and American Depositary Shares are subject by reason of
the date of issuance of the underlying Deposited Securities or otherwise. The Depositary shall notify the Company as promptly as
practicable if it imposes any legends, recitals or modifications under this paragraph.
American Depositary Shares
evidenced by a Receipt, when the Receipt is properly endorsed or accompanied by proper instruments of transfer, shall be transferable
as certificated registered securities under the laws of the State of New York. American Depositary Shares not evidenced by Receipts
shall be transferable as uncertificated registered securities under the laws of the State of New York. The Depositary, notwithstanding
any notice to the contrary, may treat the Owner of American Depositary Shares as the absolute owner thereof for the purpose of
determining the person entitled to distribution of dividends or other distributions or to any notice provided for in this Deposit
Agreement and for all other purposes, and neither the Depositary nor the Company shall have any obligation or be subject to any
liability under this Deposit Agreement to any Holder of American Depositary Shares (but only to the Owner of those American Depositary
Shares).
SECTION 2.2.
Deposit
of Shares.
Subject to the terms
and conditions of this Deposit Agreement, Shares or evidence of rights to receive Shares may be deposited under this Deposit Agreement
by delivery thereof to any Custodian, accompanied by any appropriate instruments or instructions for transfer, or endorsement,
in form satisfactory to the Custodian.
As conditions of accepting
Shares for deposit, the Depositary may require (i) any certification required by the Depositary or the Custodian in accordance
with the provisions of this Deposit Agreement, (ii) a written order directing the Depositary to deliver to, or upon the written
order of, the person or persons stated in that order American Depositary Shares representing those deposited Shares, (iii) evidence
satisfactory to the Depositary that those Shares have been re-registered in the books of the Company or the Foreign Registrar in
the name of the Depositary, a Custodian or a nominee of the Depositary or a Custodian, (iv) evidence satisfactory to the Depositary
that any necessary approval for the transfer or deposit has been granted by any governmental body in each applicable jurisdiction
and (v) an agreement or assignment, or other instrument satisfactory to the Depositary, that provides for the prompt transfer to
the Custodian of any dividend, or right to subscribe for additional Shares or to receive other property, that any person in whose
name those Shares are or have been recorded may thereafter receive upon or in respect of those Shares, or, in lieu thereof, such
agreement of indemnity or other agreement as shall be satisfactory to the Depositary.
At the request and risk
and expense of a person proposing to deposit Shares, and for the account of that person, the Depositary may receive certificates
for Shares to be deposited, together with the other instruments specified in this Section, for the purpose of forwarding those
Share certificates to the Custodian for deposit under this Deposit Agreement.
The Depositary shall
refuse, and shall instruct the Custodian to refuse, to accept Shares for deposit if the Depositary has received a notice from the
Company that the Company has restricted transfer of those Shares under the Company’s articles of association or any applicable
laws or that the deposit would result in any violation of the Company’s articles of association or any applicable laws.
The Depositary shall
instruct each Custodian that, upon each delivery to a Custodian of a certificate or certificates for Shares to be deposited under
this Deposit Agreement, together with the other documents specified in this Section, that Custodian shall, as soon as transfer
and recordation can be accomplished, present that certificate or those certificates to the Company or the Foreign Registrar, if
applicable, for transfer and recordation of the Shares being deposited in the name of the Depositary or its nominee or that Custodian
or its nominee.
Deposited Securities
shall be held by the Depositary or by a Custodian for the account and to the order of the Depositary or at such other place or
places as the Depositary shall determine.
SECTION 2.3.
Delivery
of American Depositary Shares.
The Depositary shall
instruct each Custodian that, upon receipt by that Custodian of any deposit pursuant to Section 2.2, together with the other documents
or evidence required under that Section, that Custodian shall notify the Depositary of that deposit and the person or persons to
whom or upon whose written order American Depositary Shares are deliverable in respect thereof. Upon receiving a notice of a deposit
from a Custodian, or upon the receipt of Shares or evidence of the right to receive Shares by the Depositary, the Depositary, subject
to the terms and conditions of this Deposit Agreement, shall, without unreasonable delay, deliver, to or upon the order of the
person or persons entitled thereto, the number of American Depositary Shares issuable in respect of that deposit, but only upon
payment to the Depositary of the fees and expenses of the Depositary for the delivery of those American Depositary Shares as provided
in Section 5.9, and of all taxes and governmental charges and fees payable in connection with that deposit and the transfer of
the deposited Shares.
However
, the Depositary shall deliver only whole numbers of American Depositary Shares.
SECTION 2.4.
Registration
of Transfer of American Depositary Shares; Combination and Split-up of Receipts; Interchange of Certificated and Uncertificated
American Depositary Shares.
The Depositary, subject
to the terms and conditions of this Deposit Agreement, shall register a transfer of American Depositary Shares on its transfer
books upon (i) in the case of certificated American Depositary Shares, surrender of the Receipt evidencing those American Depositary
Shares, by the Owner or by a duly authorized attorney, properly endorsed or accompanied by proper instruments of transfer or (ii)
in the case of uncertificated American Depositary Shares, receipt from the Owner of a proper instruction (including, for the avoidance
of doubt, instructions through DRS and Profile as provided in Section 2.9), and, in either case, duly stamped as may be required
by the laws of the State of New York and of the United States of America. Upon registration of a transfer, the Depositary shall
deliver the transferred American Depositary Shares to or upon the order of the person entitled thereto.
The Depositary, subject
to the terms and conditions of this Deposit Agreement, shall upon surrender of a Receipt or Receipts for the purpose of effecting
a split-up or combination of such Receipt or Receipts, execute and deliver a new Receipt or Receipts for any authorized number
of American Depositary Shares requested, evidencing the same aggregate number of American Depositary Shares as the Receipt or Receipts
surrendered.
The Depositary, upon
surrender of certificated American Depositary Shares for the purpose of exchanging for uncertificated American Depositary Shares,
shall cancel the Receipt evidencing those certificated American Depositary Shares and send the Owner a statement confirming that
the Owner is the owner of the same number of uncertificated American Depositary Shares. The Depositary, upon receipt of a proper
instruction (including, for the avoidance of doubt, instructions through DRS and Profile as provided in Section 2.9) from the Owner
of uncertificated American Depositary Shares for the purpose of exchanging for certificated American Depositary Shares, shall cancel
those uncertificated American Depositary Shares and register and deliver to the Owner a Receipt evidencing the same number of certificated
American Depositary Shares.
The Depositary may appoint
one or more co-transfer agents for the purpose of effecting registration of transfers of American Depositary Shares and combinations
and split-ups of Receipts at designated transfer offices on behalf of the Depositary. In carrying out its functions, a co-transfer
agent may require evidence of authority and compliance with applicable laws and other requirements by Owners or persons entitled
to American Depositary Shares and will be entitled to protection and indemnity to the same extent as the Depositary. The Depositary
shall notify the Company if it appoints a co-transfer agent under this paragraph.
SECTION 2.5.
Surrender
of American Depositary Shares and Withdrawal of Deposited Securities.
Upon surrender of American
Depositary Shares for the purpose of withdrawal of the Deposited Securities represented thereby and payment of the fee of the Depositary
for the surrender of American Depositary Shares as provided in Section 5.9 and payment of all taxes and governmental charges payable
in connection with that surrender and withdrawal of the Deposited Securities, and subject to the terms and conditions of this Deposit
Agreement, the Owner of those American Depositary Shares shall be entitled to delivery (to the extent delivery can then be lawfully
and practicably made), to or as instructed by that Owner, of the amount of Deposited Securities at the time represented by those
American Depositary Shares,
but not
any money or other property as to which a record date for distribution to Owners has
passed (since money or other property of that kind will be delivered or paid on the scheduled payment date to the Owner as of that
record date),
and except that
the Depositary shall not be required to accept surrender of American Depositary Shares for
the purpose of withdrawal to the extent it would require delivery of a fraction of a Deposited Security. That delivery shall be
made, as provided in this Section, without unreasonable delay.
As a condition of accepting
a surrender of American Depositary Shares for the purpose of withdrawal of Deposited Securities, the Depositary may require (i)
that each surrendered Receipt be properly endorsed in blank or accompanied by proper instruments of transfer in blank and (ii)
that the surrendering Owner execute and deliver to the Depositary a written order directing the Depositary to cause the Deposited
Securities being withdrawn to be delivered to or upon the written order of a person or persons designated in that order.
Thereupon, the Depositary
shall direct the Custodian to deliver, subject to Sections 2.6, 3.1 and 3.2, the other terms and conditions of this Deposit Agreement
and local market rules and practices, to the surrendering Owner or to or upon the written order of the person or persons designated
in the order delivered to the Depositary as above provided, the amount of Deposited Securities represented by the surrendered American
Depositary Shares, and the Depositary may charge the surrendering Owner a fee and its expenses for giving that direction by cable
(including SWIFT) or facsimile transmission.
If Deposited Securities
are delivered physically upon surrender of American Depositary Shares for the purpose of withdrawal, that delivery will be made
at the Custodian’s office,
except that
, at the request, risk and expense of an Owner surrendering American Depositary
Shares for withdrawal of Deposited Securities, and for the account of that Owner, the Depositary shall direct the Custodian to
forward any cash or other property comprising, and forward a certificate or certificates, if applicable, and other proper documents
of title, if any, for, the Deposited Securities represented by the surrendered American Depositary Shares to the Depositary for
delivery at the Depositary’s Office or to another address specified in the order received from the surrendering Owner.
SECTION 2.6.
Limitations
on Delivery, Transfer and Surrender of American Depositary Shares.
As a condition precedent
to the delivery, registration of transfer or surrender of any American Depositary Shares or split-up or combination of any Receipt
or withdrawal of any Deposited Securities, the Depositary, Custodian or Registrar may require payment from the depositor of Shares
or the presenter of the Receipt or instruction for registration of transfer or surrender of American Depositary Shares not evidenced
by a Receipt of a sum sufficient to reimburse it for any tax or other governmental charge and any stock transfer or registration
fee with respect thereto (including any such tax or charge and fee with respect to Shares being deposited or withdrawn) and payment
of any applicable fees as provided in this Deposit Agreement, may require the production of proof satisfactory to it as to the
identity and genuineness of any signature and may also require compliance with any regulations the Depositary may establish consistent
with the provisions of this Deposit Agreement, including, without limitation, this Section 2.6.
The delivery of American
Depositary Shares against deposit of Shares generally or against deposit of particular Shares may be suspended, or the registration
of transfer of American Depositary Shares in particular instances may be refused, or the registration of transfer of outstanding
American Depositary Shares generally may be suspended, during any period when the transfer books of the Depositary are closed,
or if any such action is deemed necessary or advisable by the Depositary or the Company at any time or from time to time because
of any requirement of law or of any government or governmental body or commission, or under any provision of this Deposit Agreement,
or for any other reason. Notwithstanding anything to the contrary in this Deposit Agreement, the surrender of outstanding American
Depositary Shares and withdrawal of Deposited Securities may not be suspended, subject only to (i) temporary delays caused by closing
of the transfer books of the Depositary or the Company or the Foreign Registrar, if applicable, or the deposit of Shares in connection
with voting at a shareholders’ meeting, or the payment of dividends, (ii) the payment of fees, taxes and similar charges,
and (iii) compliance with any U.S. or foreign laws or governmental regulations relating to the American Depositary Shares or to
the withdrawal of the Deposited Securities.
The Depositary shall
not knowingly accept for deposit under this Deposit Agreement any Shares that, at the time of deposit, are Restricted Securities
or for which the Depositary has received written instructions from the Company that the deposit of those Shares would violate applicable
law or regulation.
SECTION 2.7.
Lost
Receipts, etc.
If a Receipt is mutilated,
destroyed, lost or stolen, the Depositary shall deliver to the Owner the American Depositary Shares evidenced by that Receipt in
uncertificated form or, if requested by the Owner, execute and deliver a new Receipt of like tenor in exchange and substitution
for such mutilated Receipt, upon surrender and cancellation of that mutilated Receipt, or in lieu of and in substitution for that
destroyed, lost or stolen Receipt.
However
, before the Depositary will deliver American Depositary Shares in uncertificated
form or execute and deliver a new Receipt, in substitution for a destroyed, lost or stolen Receipt, the Owner must (a) file with
the Depositary (i) a request for that replacement before the Depositary has notice that the Receipt has been acquired by a bona
fide purchaser and (ii) a sufficient indemnity bond and (b) satisfy any other reasonable requirements imposed by the Depositary.
SECTION 2.8.
Cancellation
and Destruction of Surrendered Receipts.
The Depositary shall
cancel all Receipts surrendered to it and is authorized to destroy Receipts so cancelled.
SECTION 2.9.
DTC
Direct Registration System and Profile Modification System.
(a) Notwithstanding
the provisions of Section 2.4, the parties acknowledge that DTC’s Direct Registration System (“
DRS
”) and
Profile Modification System (“
Profile
”) apply to the American Depositary Shares upon acceptance thereof to DRS
by DTC. DRS is the system administered by DTC that facilitates interchange between registered holding of uncertificated securities
and holding of security entitlements in those securities through DTC and a DTC participant. Profile is a required feature of DRS
that allows a DTC participant, claiming to act on behalf of an Owner of American Depositary Shares, to direct the Depositary to
register a transfer of those American Depositary Shares to DTC or its nominee and to deliver those American Depositary Shares to
the DTC account of that DTC participant without receipt by the Depositary of prior authorization from the Owner to register that
transfer.
(b) In
connection with DRS/Profile, the parties acknowledge that the Depositary will not determine whether the DTC participant that is
claiming to be acting on behalf of an Owner in requesting a registration of transfer and delivery as described in paragraph (a)
above has the actual authority to act on behalf of that Owner (notwithstanding any requirements under the Uniform Commercial Code).
For the avoidance of doubt, the provisions of Sections 5.3 and 5.8 apply to the matters arising from the use of the DRS/Profile.
The parties agree that the Depositary’s reliance on and compliance with instructions received by the Depositary through the
DRS/Profile system and otherwise in accordance with this Deposit Agreement shall not constitute negligence or bad faith on the
part of the Depositary.
ARTICLE
3. CERTAIN OBLIGATIONS OF OWNERS AND HOLDERS OF AMERICAN DEPOSITARY
SHARES
SECTION 3.1.
Filing
Proofs, Certificates and Other Information.
Any person presenting
Shares for deposit or any Owner or Holder may be required from time to time to file with the Depositary or the Custodian such proof
of citizenship or residence, exchange control approval, or such information relating to the registration on the books of the Company
or the Foreign Registrar, if applicable, to execute such certificates and to make such representations and warranties, as the Depositary
may deem necessary or proper. The Depositary may withhold the delivery or registration of transfer of American Depositary Shares,
the distribution of any dividend or other distribution or of the proceeds thereof or the delivery of any Deposited Securities until
that proof or other information is filed or those certificates are executed or those representations and warranties are made.
Upon the reasonable written
request and at the expense of the Company, the Depositary shall, as promptly as practicable, provide to the Company copies or originals,
if necessary or appropriate, of any proofs of citizenship or residence, taxpayer status, exchange control approval, information,
certificate or other representations and warranties that the Depositary receives under this Section 3.1 from the Owner or Holder
or any person presenting Shares for deposit, to the extent that disclosure is permitted under applicable law. Each Owner and Holder
agrees to provide any information reasonably requested by the Company or the Depositary pursuant to this Section 3.1. Neither the
Company nor the Depositary is responsible for monitoring the Owners’ or the Holders’ compliance with applicable laws
and regulations or their legal right to acquire Shares or American Depositary Shares.
SECTION 3.2.
Liability
of Owner for Taxes.
If any tax or other governmental
charge shall become payable by the Custodian or the Depositary with respect to or in connection with any American Depositary Shares
or any Deposited Securities represented by any American Depositary Shares or in connection with a transaction to which Section
4.8 applies, that tax or other governmental charge shall be payable by the Owner of those American Depositary Shares to the Depositary.
The Depositary may refuse to register any transfer of those American Depositary Shares or any withdrawal of Deposited Securities
represented by those American Depositary Shares until that payment is made, and may withhold any dividends or other distributions
or the proceeds thereof, or may sell for the account of the Owner any part or all of the Deposited Securities represented by those
American Depositary Shares and apply those dividends or other distributions or the net proceeds of any sale of that kind in payment
of that tax or other governmental charge
but
, even after a sale of that kind, the Owner of those American Depositary Shares
shall remain liable for any deficiency. The Depositary shall distribute any net proceeds of a sale made under this Section that
are not used to pay taxes or governmental charges to the Owners entitled to them in accordance with Section 4.1. If the number
of Shares represented by each American Depositary Share decreases as a result of a sale of Deposited Securities under this Section,
the Depositary may call for surrender of the American Depositary Shares to be exchanged on a mandatory basis for a lesser number
of American Depositary Shares and may sell American Depositary Shares to the extent necessary to avoid distributing fractions of
American Depositary Shares in that exchange and distribute the net proceeds of that sale to the Owners entitled to them.
SECTION 3.3.
Warranties
on Deposit of Shares.
Every person depositing
Shares under this Deposit Agreement shall be deemed thereby to represent and warrant that those Shares and each certificate therefor,
if applicable, are validly issued, fully paid and nonassessable and were not issued in violation of any preemptive or similar rights
of the holders of outstanding securities of the Company and that the person making that deposit is duly authorized so to do. Every
depositing person shall also be deemed to represent that the Shares, at the time of deposit, are not Restricted Securities. All
representations and warranties deemed made under this Section shall survive the deposit of Shares and delivery of American Depositary
Shares.
SECTION 3.4.
Disclosure
of Interests.
When required in order
to comply with applicable laws and regulations or the articles of association or similar document of the Company, the Company may
from time to time request each Owner and Holder to provide to the Depositary information relating to: (a) the capacity
in which it holds American Depositary Shares, (b) the identity of any Holders or other persons or entities then
or previously interested in those American Depositary Shares and the nature of those interests and (c) any other matter
where disclosure of such matter is, in the Company’s reasonable opinion, required for that compliance. Each Owner
and Holder agrees to provide all information known to it in response to a request made pursuant to this Section. Each Holder consents
to the disclosure by the Depositary and the Owner or any other Holder through which it holds American Depositary Shares, directly
or indirectly, of all information responsive to a request made pursuant to this Section relating to that Holder that is known
to that Owner or other Holder. The Depositary agrees to use reasonable efforts to comply with written instructions requesting
that the Depositary forward any request authorized under this Section to the Owners and to forward to the Company any responses
it receives in response to that request. The Depositary may charge the Company a fee and its expenses for complying with requests
under this Section 3.4.
As of the date of this
Deposit Agreement, each Owner and Holder agrees, if it instructs the Depositary to exercise voting rights with respect to Deposited
Shares, that it will comply with any applicable Israeli law requiring it to, inter alia, disclose any personal interest it might
have in the matter on the agenda of the general meeting. The Company undertakes no obligations to update this Section to reflect
changes in law that occur after the date of this Deposit Agreement.
ARTICLE 4. THE
DEPOSITED SECURITIES
SECTION 4.1.
Cash
Distributions.
Whenever the Depositary
receives any cash dividend or other cash distribution on Deposited Securities, the Depositary shall, subject to the provisions
of Section 4.5, convert that dividend or other distribution into Dollars and distribute the amount thus received (net of the fees
and expenses of the Depositary as provided in Section 5.9) to the Owners entitled thereto, in proportion to the number of
American Depositary Shares representing those Deposited Securities held by them respectively;
provided
,
however
,
that if the Custodian or the Depositary shall be required to withhold and does withhold from that cash dividend or other cash distribution
an amount on account of taxes or other governmental charges, the amount distributed to the Owners of the American Depositary Shares
representing those Deposited Securities shall be reduced accordingly.
However
, the Depositary will not pay any Owner a fraction
of one cent, but will round each Owner’s entitlement to the nearest whole cent.
The Company or its agent
will remit to the appropriate governmental agency in each applicable jurisdiction all amounts withheld and owing to such agency.
The Depositary will forward to the Company or its agent such information from its records as the Company may reasonably request
to enable the Company or its agent to file necessary reports with governmental agencies.
If a cash distribution
would represent a return of all or substantially all the value of the Deposited Securities underlying American Depositary Shares,
the Depositary may, after consultation with the Company to the extent practicable, require surrender of those American Depositary
Shares and may require payment of or deduct the fee for surrender of American Depositary Shares (whether or not it is also requiring
surrender of American Depositary Shares) as a condition of making that cash distribution. A distribution of that kind shall be
a
Termination Option Event
.
SECTION 4.2.
Distributions
Other Than Cash, Shares or Rights.
Subject to the provisions
of Sections 4.11 and 5.9, whenever the Depositary receives any distribution other than a distribution described in Section 4.1,
4.3 or 4.4 on Deposited Securities (but not in exchange for or in conversion or in lieu of Deposited Securities), the Depositary
shall cause the securities or property received by it to be distributed to the Owners entitled thereto, after deduction or upon
payment of any fees and expenses of the Depositary and any taxes or other governmental charges, in proportion to the number of
American Depositary Shares representing such Deposited Securities held by them respectively, in any manner that the Depositary
deems equitable and practicable for accomplishing that distribution (which may be a distribution of depositary shares representing
the securities received);
provided
,
however
, that if in the opinion of the Depositary such distribution cannot be
made proportionately among the Owners entitled thereto, or if for any other reason (including, but not limited to, any requirement
that the Company or the Depositary withhold an amount on account of taxes or other governmental charges or that securities received
must be registered under the Securities Act of 1933 in order to be distributed to Owners or Holders) the Depositary deems such
distribution not to be lawful and feasible, the Depositary may, after consultation with the Company to the extent practicable,
adopt such other method as it may deem equitable and practicable for the purpose of effecting such distribution, including, but
not limited to, the public or private sale of the securities or property thus received, or any part thereof, and distribution of
the net proceeds of any such sale (net of the fees and expenses of the Depositary as provided in Section 5.9) to the Owners entitled
thereto, all in the manner and subject to the conditions set forth in Section 4.1. The Depositary may withhold any distribution
of securities under this Section 4.2 if it has not received satisfactory assurances from the Company that the distribution does
not require registration under the Securities Act of 1933. The Depositary may sell, by public or private sale, an amount of securities
or other property it would otherwise distribute under this Section 4.2 that is sufficient to pay its fees and expenses in respect
of that distribution.
If a distribution under
this Section 4.2 would represent a return of all or substantially all the value of the Deposited Securities underlying American
Depositary Shares, the Depositary may require surrender of those American Depositary Shares and may require payment of or deduct
the fee for surrender of American Depositary Shares (whether or not it is also requiring surrender of American Depositary Shares)
as a condition of making that distribution. A distribution of that kind shall be a
Termination Option Event
.
SECTION 4.3.
Distributions
in Shares.
Whenever the Depositary
receives any distribution on Deposited Securities consisting of a dividend in, or free distribution of, Shares, the Depositary
may and, if so requested in writing by the Company, shall, deliver to the Owners entitled thereto, in proportion to the number
of American Depositary Shares representing those Deposited Securities held by them respectively, an aggregate number of American
Depositary Shares representing the amount of Shares received as that dividend or free distribution, subject to the terms and conditions
of this Deposit Agreement with respect to the deposit of Shares and issuance of American Depositary Shares, including withholding
of any tax or governmental charge as provided in Section 4.11 and payment of the fees and expenses of the Depositary as provided
in Section 5.9 (and the Depositary may sell, by public or private sale, an amount of the Shares received (or American Depositary
Shares representing those Shares) sufficient to pay its fees and expenses in respect of that distribution). In lieu of delivering
fractional American Depositary Shares, the Depositary may sell the amount of Shares represented by the aggregate of those fractions
(or American Depositary Shares representing those Shares) and distribute the net proceeds, all in the manner and subject to the
conditions described in Section 4.1. If and to the extent that additional American Depositary Shares are not delivered and Shares
or American Depositary Shares are not sold, each American Depositary Share shall thenceforth also represent the additional Shares
distributed on the Deposited Securities represented thereby.
If the Company declares
a distribution in which holders of Deposited Securities have a right to elect whether to receive cash, Shares or other securities
or a combination of those things, or a right to elect to have a distribution sold on their behalf, the Depositary may, after consultation
with the Company, make that right of election available for exercise by Owners in any manner the Depositary considers to be lawful
and practical. As a condition of making a distribution election right available to Owners, the Depositary may require satisfactory
assurances from the Company that doing so does not require registration of any securities under the Securities Act of 1933.
SECTION 4.4.
Rights.
(a) If
rights are granted to the Depositary in respect of deposited Shares to purchase additional Shares or other securities, the Company
and the Depositary shall endeavor to consult as to the actions, if any, the Depositary should take in connection with that grant
of rights. The Depositary may, to the extent deemed by it to be lawful and practical (i) if requested in writing by the Company,
grant to all or certain Owners rights to instruct the Depositary to purchase the securities to which the rights relate and deliver
those securities or American Depositary Shares representing those securities to Owners, (ii) if requested in writing by the Company,
deliver the rights to or to the order of certain Owners, or (iii) sell the rights to the extent practicable and distribute the
net proceeds of that sale to Owners entitled to those proceeds. To the extent rights are not exercised, delivered or disposed of
under (i), (ii) or (iii) above, the Depositary shall permit the rights to lapse unexercised.
(b) If
the Depositary will act under (a)(i) above, the Company and the Depositary will enter into a separate agreement setting forth the
conditions and procedures applicable to the particular offering. Upon instruction from an applicable Owner in the form the Depositary
specified and upon payment by that Owner to the Depositary of an amount equal to the purchase price of the securities to be received
upon the exercise of the rights, the Depositary shall, on behalf of that Owner, exercise the rights and purchase the securities.
The purchased securities shall be delivered to, or as instructed by, the Depositary. The Depositary shall (i) deposit the purchased
Shares under this Deposit Agreement and deliver American Depositary Shares representing those Shares to that Owner or (ii) deliver
or cause the purchased Shares or other securities to be delivered to or to the order of that Owner. The Depositary will not act
under (a)(i) above unless the offer and sale of the securities to which the rights relate are registered under the Securities Act
of 1933 or the Depositary has received an opinion of United States counsel that is satisfactory to it to the effect that those
securities may be sold and delivered to the applicable Owners without registration under the Securities Act of 1933.
(c) If
the Depositary will act under (a)(ii) above, the Company and the Depositary will enter into a separate agreement setting forth
the conditions and procedures applicable to the particular offering. Upon (i) the request of an applicable Owner to deliver the
rights allocable to the American Depositary Shares of that Owner to an account specified by that Owner to which the rights can
be delivered and (ii) receipt of such documents as the Company and the Depositary agreed to require to comply with applicable law,
the Depositary will deliver those rights as requested by that Owner.
(d) If
the Depositary will act under (a)(iii) above, the Depositary will use reasonable efforts to sell the rights in proportion to the
number of American Depositary Shares held by the applicable Owners and pay the net proceeds to the Owners otherwise entitled to
the rights that were sold, upon an averaged or other practical basis without regard to any distinctions among such Owners because
of exchange restrictions or the date of delivery of any American Depositary Shares or otherwise.
(e) Payment
or deduction of the fees of the Depositary as provided in Section 5.9 and payment or deduction of the expenses of the Depositary
and any applicable taxes or other governmental charges shall be conditions of any delivery of securities or payment of cash proceeds
under this Section 4.4.
(f) The
Depositary shall not be responsible for any failure to determine that it may be lawful or feasible to make rights available to
or exercise rights on behalf of Owners in general or any Owner in particular, or to sell rights.
SECTION 4.5.
Conversion
of Foreign Currency.
Whenever the Depositary
or the Custodian receives foreign currency, by way of dividends or other distributions or the net proceeds from the sale of securities,
property or rights, and if at the time of the receipt thereof the foreign currency so received can in the judgment of the Depositary
be converted on a reasonable basis into Dollars and the resulting Dollars transferred to the United States, the Depositary shall
convert or cause to be converted by sale or in any other manner that it may determine that foreign currency into Dollars, and those
Dollars shall be distributed to the Owners entitled thereto. A cash distribution may be made upon an averaged or other practicable
basis without regard to any distinctions among Owners based on exchange restrictions, the date of delivery of any American Depositary
Shares or otherwise and shall be net of any expenses of conversion into Dollars incurred by the Depositary as provided in Section 5.9.
If a conversion of foreign
currency or the repatriation or distribution of Dollars can be effected only with the approval or license of any government or
agency thereof, the Depositary may, but will not be required to, file an application for that approval or license.
If the Depositary determines
that in its judgment any foreign currency received by the Depositary or the Custodian is not convertible on a reasonable basis
into Dollars transferable to the United States, or if any approval or license of any government or agency thereof that is required
for such conversion is not filed or sought by the Depositary or is not obtained within a reasonable period as determined by the
Depositary, the Depositary may distribute the foreign currency received by the Depositary to, or in its discretion may hold such
foreign currency uninvested and without liability for interest thereon for the respective accounts of, the Owners entitled to receive
the same.
If any conversion of
foreign currency, in whole or in part, cannot be effected for distribution to some of the Owners entitled thereto, the Depositary
may in its discretion make that conversion and distribution in Dollars to the extent practicable and permissible to the Owners
entitled thereto and may distribute the balance of the foreign currency received by the Depositary to, or hold that balance uninvested
and without liability for interest thereon for the account of, the Owners entitled thereto.
The Depositary may convert
currency itself or through any of its affiliates and, in those cases, acts as principal for its own account and not as agent, advisor,
broker or fiduciary on behalf of any other person and earns revenue, including, without limitation, transaction spreads, that it
will retain for its own account. The revenue is based on, among other things, the difference between the exchange rate assigned
to the currency conversion made under this Deposit Agreement and the rate that the Depositary or its affiliate receives when buying
or selling foreign currency for its own account. The Depositary makes no representation that the exchange rate used or obtained
in any currency conversion under this Deposit Agreement will be the most favorable rate that could be obtained at the time or that
the method by which that rate will be determined will be the most favorable to Owners, subject to the Depositary’s obligations
under Section 5.3. The methodology used to determine exchange rates used in currency conversions is available upon request.
SECTION 4.6.
Fixing
of Record Date.
Whenever a cash dividend,
cash distribution or any other distribution is made on Deposited Securities or rights to purchase Shares or other securities are
issued with respect to Deposited Securities (which rights will be delivered to or exercised or sold on behalf of Owners in accordance
with Section 4.4) or the Depositary receives notice that a distribution or issuance of that kind will be made, or whenever the
Depositary receives notice that a meeting of holders of Shares will be held in respect of which the Company has requested the Depositary
to send a notice under Section 4.7, or whenever the Depositary will assess a fee or charge against the Owners, or whenever the
Depositary causes a change in the number of Shares that are represented by each American Depositary Share, or whenever the Depositary
otherwise finds it necessary or convenient, the Depositary shall fix a record date, which shall be the same as, or as near as practicable
to, any corresponding record date set by the Company with respect to Shares, (a) for the determination of the Owners (i) who shall
be entitled to receive the benefit of that dividend or other distribution or those rights, (ii) who shall be entitled to give instructions
for the exercise of voting rights at that meeting or (iii) who shall be responsible for that fee or charge or (iv) for any other
purpose for which the record date was set, or (b) on or after which each American Depositary Share will represent the changed number
of Shares. Subject to the provisions of Sections 4.1 through 4.5 and to the other terms and conditions of this Deposit Agreement,
the Owners on a record date fixed by the Depositary shall be entitled to receive the amount distributable by the Depositary with
respect to that dividend or other distribution or those rights or the net proceeds of sale thereof in proportion to the number
of American Depositary Shares held by them respectively, to give voting instructions or to act in respect of the other matter for
which that record date was fixed, or be responsible for that fee or charge, as the case may be.
SECTION 4.7.
Voting
of Deposited Shares.
(a) Upon
receipt of notice from the Company of any meeting of holders of Shares at which holders of Shares will be entitled to vote, if
requested in writing by the Company, the Depositary shall, as soon as practicable thereafter, Disseminate to the Owners a
notice, the form of which shall be prepared by the Depositary and approved by the Company, that shall contain (i) the information
contained in the notice of meeting received by the Depositary, (ii) a statement that the Owners as of the close of business
on a specified record date will be entitled, subject to any applicable provision of Israeli law and of the articles of association
or similar documents of the Company, to instruct the Depositary as to the exercise of the voting rights pertaining to the amount
of Shares represented by their respective American Depositary Shares, (iii) a statement as to the manner in which those instructions
may be given and (iv) the last date on which the Depositary will accept instructions (the “
Instruction Cutoff Date
”).
(b) Upon
the written request of an Owner of American Depositary Shares, as of the date of the request or, if a record date was specified
by the Depositary, as of that record date, received on or before any Instruction Cutoff Date established by the
Depositary, the Depositary may, and if the Depositary sent a notice under the preceding paragraph shall, endeavor, in so far as
practicable, to vote or cause to be voted the amount of deposited Shares represented by those American Depositary Shares in accordance
with the instructions set forth in that request. The Depositary shall not vote or attempt to exercise the right to vote that attaches
to the deposited Shares other than in accordance with instructions given by Owners and received by the Depositary.
(c) There
can be no assurance that Owners generally or any Owner in particular will receive the notice described in paragraph (a) above
in time to enable Owners to give instructions to the Depositary prior to the Instruction Cutoff Date.
(d) In
order to give Owners a reasonable opportunity to instruct the Depositary as to the exercise of voting rights relating to Shares,
if the Company will request the Depositary to Disseminate a notice under paragraph (a) above, the Company shall give the Depositary
notice of the meeting, details concerning the matters to be voted upon and copies of materials to be made available to holders
of Shares in connection with the meeting not less than 45 days prior to the meeting date.
SECTION 4.8.
Tender
and Exchange Offers; Redemption, Replacement or Cancellation of Deposited Securities.
(a) The
Depositary shall not tender any Deposited Securities in response to any voluntary cash tender offer, exchange offer or similar
offer made to holders of Deposited Securities (a “
Voluntary Offer
”), except when instructed in writing to do
so by an Owner surrendering American Depositary Shares and subject to any conditions or procedures the Depositary may require.
(b) If
the Depositary receives a written notice that Deposited Securities have been redeemed for cash or otherwise purchased for cash
in a transaction that is mandatory and binding on the Depositary as a holder of those Deposited Securities (a “
Redemption
”),
the Depositary, at the expense of the Company, shall (i) if required, surrender Deposited Securities that have been redeemed to
the issuer of those securities or its agent on the redemption date, (ii) Disseminate a notice to Owners (A) notifying them of that
Redemption, (B) calling for surrender of a corresponding number of American Depositary Shares and (C) notifying them that the called
American Depositary Shares have been converted into a right only to receive the money received by the Depositary upon that Redemption
and those net proceeds shall be the Deposited Securities to which Owners of those converted American Depositary Shares shall be
entitled upon surrenders of those American Depositary Shares in accordance with Section 2.5 or 6.2 and (iii) distribute the money
received upon that Redemption to the Owners entitled to it upon surrender by them of called American Depositary Shares in accordance
with Section 2.5 (and, for the avoidance of doubt, Owners shall not be entitled to receive that money under Section 4.1). If the
Redemption affects less than all the Deposited Securities, the Depositary shall call for surrender a corresponding portion of the
outstanding American Depositary Shares and only those American Depositary Shares will automatically be converted into a right to
receive the net proceeds of the Redemption. The Depositary shall allocate the American Depositary Shares converted under the preceding
sentence among the Owners pro-rata to their respective holdings of American Depositary Shares immediately prior to the Redemption,
except that
the allocations may be adjusted so that no fraction of a converted American Depositary Share is allocated to
any Owner. A Redemption of all or substantially all of the Deposited Securities shall be a
Termination Option Event
.
(c) If
the Depositary is notified of or there occurs any change in nominal value or any subdivision, combination or any other reclassification
of the Deposited Securities or any recapitalization, reorganization, sale of assets substantially as an entirety, merger or consolidation
affecting the issuer of the Deposited Securities or to which it is a party that is mandatory and binding on the Depositary as a
holder of Deposited Securities and, as a result, securities or other property have been or will be delivered in exchange, conversion,
replacement or in lieu of, Deposited Securities (a “
Replacement
”), the Depositary shall, if required, surrender
the old Deposited Securities affected by that Replacement of Shares and hold, as new Deposited Securities under this Deposit Agreement,
the new securities or other property delivered to it in that Replacement.
However
, the Depositary may elect to sell those
new Deposited Securities if in the opinion of the Depositary it is not lawful or not practical for it to hold those new Deposited
Securities under this Deposit Agreement because those new Deposited Securities may not be distributed to Owners without registration
under the Securities Act of 1933 or for any other reason, at public or private sale, at such places and on such terms as it deems
proper and proceed as if those new Deposited Securities had been Redeemed under paragraph (b) above. A Replacement shall be a
Termination
Option Event
.
(d) In
the case of a Replacement where the new Deposited Securities will continue to be held under this Deposit Agreement, the Depositary
may call for the surrender of outstanding Receipts to be exchanged for new Receipts specifically describing the new Deposited Securities
and the number of those new Deposited Securities represented by each American Depositary Share. If the number of Shares represented
by each American Depositary Share decreases as a result of a Replacement, the Depositary may call for surrender of the American
Depositary Shares to be exchanged on a mandatory basis for a lesser number of American Depositary Shares and may sell American
Depositary Shares to the extent necessary to avoid distributing fractions of American Depositary Shares in that exchange and distribute
the net proceeds of that sale to the Owners entitled to them.
(e) If
there are no Deposited Securities with respect to American Depositary Shares, including if the Deposited Securities are cancelled,
or the Deposited Securities with respect to American Depositary Shares have become apparently worthless, the Depositary may call
for surrender of those American Depositary Shares or may cancel those American Depositary Shares, upon notice to Owners, and that
condition shall be a
Termination Option Event
.
SECTION 4.9.
Reports.
The Depositary shall
make available for inspection by Owners at its Office any reports and communications, including any proxy solicitation material,
received from the Company which are both (a) received by the Depositary as the holder of the Deposited Securities and (b) made
generally available to the holders of those Deposited Securities by the Company. The Company shall furnish reports and communications,
including any proxy soliciting material to which this Section applies, to the Depositary in English, to the extent those materials
are required to be translated into English pursuant to any regulations of the Commission.
SECTION 4.10.
Lists
of Owners.
Upon written request
by the Company, the Depositary shall, at the expense of the Company, furnish to it a list, as of a recent date, of the names, addresses
and American Depositary Share holdings of all Owners.
SECTION 4.11.
Withholding.
If the Depositary determines
that any distribution received or to be made by the Depositary (including Shares and rights to subscribe therefor) is subject to
any tax or other governmental charge that the Depositary is obligated to withhold, the Depositary may sell, by public or private
sale, all or a portion of the distributed property (including Shares and rights to subscribe therefor) in the amounts and manner
the Depositary deems necessary and practicable to pay those taxes or charges, and the Depositary shall distribute the net proceeds
of that sale, after deduction of those taxes or charges, to the Owners entitled thereto in proportion to the number of American
Depositary Shares held by them respectively.
Services for Owners and
Holders that may permit them to obtain reduced rates of tax withholding at source or reclaim excess tax withheld, and the fees
and costs associated with using services of that kind, are not provided under, and are outside the scope of, this Deposit Agreement.
Each Owner and Holder
agrees to indemnify the Company, the Depositary, the Custodian and their respective directors, employees, agents and affiliates
for, and hold each of them harmless against, any claim by any governmental authority with respect to taxes, additions to tax, penalties
or interest arising out of any refund of taxes, reduced withholding at source or other tax benefit received by it.
The Depositary shall,
to the extent required by U.S. law, report to the Owners any taxes or governmental charges withheld from or paid out of a distribution
on Deposited Securities by it, the Custodian or, to the extent such information is received from the Company, the Company.
ARTICLE 5. THE
DEPOSITARY, THE CUSTODIANS AND THE COMPANY
SECTION 5.1.
Maintenance
of Office and Transfer Books by the Depositary.
Until termination of
this Deposit Agreement in accordance with its terms, the Depositary shall maintain facilities for the execution and delivery, registration,
registration of transfers and surrender of American Depositary Shares in accordance with the provisions of this Deposit Agreement.
The Depositary shall
keep books for the registration of American Depositary Shares, which shall be open for inspection by the Owners at the Depositary’s
Office during regular business hours,
provided
that such inspection is not for the purpose of communicating with Owners
in the interest of a business or object other than the business of the Company or a matter related to this Deposit Agreement or
the American Depositary Shares.
The Depositary may close
the transfer books, at any time or from time to time, when deemed expedient by it in connection with the performance of its duties
under this Deposit Agreement.
If any American Depositary
Shares are listed on one or more stock exchanges, the Depositary shall act as Registrar or appoint a Registrar or one or more co-registrars
for registry of those American Depositary Shares in accordance with any requirements of that exchange or those exchanges.
The Company shall have
the right, at all reasonable times, to inspect the transfer and registration records of the Depositary relating to the American
Depositary Shares, to make copies thereof and to request the Depositary and the Registrar in writing to supply, at the Company’s
expense, copies of such portions of such records as the Company may reasonably request.
SECTION 5.2.
Prevention
or Delay of Performance by the Company or the Depositary.
Neither the Depositary
nor the Company nor any of their respective directors, employees, agents or affiliates shall incur any liability to any Owner or
Holder:
(i) if by reason of (A)
any provision of any present or future law or regulation or other act of the government of the United States, any State of the
United States or any other state or jurisdiction, or of any governmental or regulatory authority or stock exchange; (B) (in the
case of the Depositary only) any provision, present or future, of the articles of association or similar document of the Company,
or by reason of any provision of any securities issued or distributed by the Company, or any offering or distribution thereof;
or (C) any event or circumstance, whether natural or caused by a person or persons, that is beyond the ability of the Depositary
or the Company, as the case may be, to prevent or counteract by reasonable care or effort (including, but not limited to earthquakes,
floods, severe storms, fires, explosions, war, terrorism, civil unrest, labor disputes or criminal acts; interruptions or malfunctions
of utility services, Internet or other communications lines or systems; unauthorized access to or attacks on computer systems or
websites; or other failures or malfunctions of computer hardware or software or other systems or equipment), the Depositary or
the Company is, directly or indirectly, prevented from, forbidden to or delayed in, or could be subject to any civil or criminal
penalty on account of doing or performing and therefore does not do or perform, any act or thing that, by the terms of this Deposit
Agreement or the Deposited Securities, it is provided shall be done or performed;
(ii) for any exercise
of, or failure to exercise, any discretion provided for in this Deposit Agreement (including any determination by the Depositary
to take, or not take, any action that this Deposit Agreement provides the Depositary may take);
(iii) for the inability
of any Owner or Holder to benefit from any distribution, offering, right or other benefit that is made available to holders of
Deposited Securities but is not, under the terms of this Deposit Agreement, made available to Owners or Holders; or
(iv) for any special,
consequential or punitive damages for any breach of the terms of this Deposit Agreement.
Where, by the terms of
a distribution to which Section 4.1, 4.2 or 4.3 applies, or an offering to which Section 4.4 applies, or for any other
reason, that distribution or offering may not be made available to Owners, and the Depositary may not dispose of that distribution
or offering on behalf of Owners and make the net proceeds available to Owners, then the Depositary shall not make that distribution
or offering available to Owners, and shall allow any rights, if applicable, to lapse.
SECTION 5.3.
Obligations
of the Depositary and the Company.
Neither the Company nor
any of its directors, officers, employees, agents, controlling persons or affiliates assumes any obligation nor shall any of them
be subject to any liability under this Deposit Agreement to any Owner or Holder, except that the Company agrees to perform its
obligations specifically set forth in this Deposit Agreement without negligence or bad faith.
Neither the Depositary
nor any of its directors, officers, employees, agents, controlling persons or affiliates assumes any obligation nor shall any of
them be subject to any liability under this Deposit Agreement to any Owner or Holder (including, without limitation, liability
with respect to the validity or worth of the Deposited Securities), except that the Depositary agrees to perform its obligations
specifically set forth in this Deposit Agreement without negligence or bad faith, and the Depositary shall not be a fiduciary or
have any fiduciary duty to Owners or Holders.
Neither the Depositary
nor the Company nor any of their respective directors, officers, employees, agents, controlling persons or affiliates shall be
under any obligation to appear in, prosecute or defend any action, suit or other proceeding in respect of any Deposited Securities
or in respect of the American Depositary Shares on behalf of any Owner or Holder or any other person.
Each of the Depositary
and the Company may rely, and shall be protected in relying upon, any written notice, request, direction or other document believed
by it to be genuine and to have been signed or presented by the proper party or parties.
Neither the Depositary
nor the Company nor any of their respective directors, officers, employees, agents, controlling persons or affiliates shall be
liable for any action or non-action by it in reliance upon the advice of or information from legal counsel, accountants, any person
presenting Shares for deposit, any Owner or any other person believed by it in good faith to be competent to give such advice or
information.
The Depositary shall
not be liable for any acts or omissions made by a successor depositary whether in connection with a previous act or omission of
the Depositary or in connection with any matter arising wholly after the removal or resignation of the Depositary, provided that
in connection with the issue out of which such potential liability arises the Depositary performed its obligations without negligence
or bad faith while it acted as Depositary.
Neither the Company nor
the Depositary shall be liable for the acts or omissions of any securities depository, clearing agency or settlement system in
connection with or arising out of book-entry settlement of American Depositary Shares or Deposited Securities or otherwise.
In the absence of bad
faith on its part, the Depositary shall not be responsible for any failure to carry out any instructions to vote any of the Deposited
Securities, or for the manner in which any such vote is cast or the effect of any such vote.
The Depositary shall
have no duty to make any determination or provide any information as to the tax status of the Company or any liability for any
tax consequences that may be incurred by Owners or Holders as a result of owning or holding American Depositary Shares. The Depositary
shall not be liable for the inability or failure of an Owner or Holder to obtain the benefit of a foreign tax credit, reduced rate
of withholding or refund of amounts withheld in respect of tax or any other tax benefit.
No disclaimer of liability
under the United States federal securities laws is intended by any provision of this Deposit Agreement.
SECTION 5.4.
Resignation
and Removal of the Depositary.
The Depositary may at
any time resign as Depositary hereunder by written notice of its election so to do delivered to the Company, to become effective
upon the appointment of a successor depositary and its acceptance of that appointment as provided in this Section. The effect of
resignation if a successor depositary is not appointed is provided for in Section 6.2.
The Depositary may at
any time be removed by the Company by 90 days’ prior written notice of that removal, to become effective upon the later of
(i) the 90th day after delivery of the notice to the Depositary and (ii) the appointment of a successor depositary and its acceptance
of its appointment as provided in this Section.
If the Depositary resigns
or is removed, the Company shall use its best efforts to appoint a successor depositary, which shall be a bank or trust company
having an office in the Borough of Manhattan, The City of New York. Every successor depositary shall execute and deliver to the
Company an instrument in writing accepting its appointment under this Deposit Agreement. If the Depositary receives notice from
the Company that a successor depositary has been appointed following its resignation or removal, the Depositary, upon payment of
all sums due it from the Company, shall deliver to its successor a register listing all the Owners and their respective holdings
of outstanding American Depositary Shares and shall deliver the Deposited Securities to or to the order of its successor. When
the Depositary has taken the actions specified in the preceding sentence (i) the successor shall become the Depositary and shall
have all the rights and shall assume all the duties of the Depositary under this Deposit Agreement and (ii) the predecessor depositary
shall cease to be the Depositary and shall be discharged and released from all obligations under this Deposit Agreement, except
for its duties under Section 5.8 with respect to the time before that discharge. A successor Depositary shall notify the Owners
of its appointment as soon as practical after assuming the duties of Depositary.
Any corporation or other
entity into or with which the Depositary may be merged or consolidated shall be the successor of the Depositary without the execution
or filing of any document or any further act.
SECTION 5.5.
The
Custodian.
The Custodian shall be
subject at all times and in all respects to the directions of the Depositary and shall be responsible solely to it. The Depositary
in its discretion may at any time appoint a substitute or additional custodian or custodians, each of which shall thereafter be
one of the Custodians under this Deposit Agreement. If the Depositary receives notice that a Custodian is resigning and, upon the
effectiveness of that resignation there would be no Custodian acting under this Deposit Agreement, the Depositary shall, as promptly
as practicable after receiving that notice, appoint a substitute custodian or custodians, each of which shall thereafter be a Custodian
under this Deposit Agreement. The Depositary shall require any Custodian that resigns or is removed to deliver all Deposited Securities
held by it to another Custodian.
SECTION 5.6.
Notices
and Reports.
If the Company takes
or decides to take any corporate action of a kind that is addressed in Sections 4.1 to 4.4, or 4.6 to 4.8, or that effects or will
effect a change of the name or legal structure of the Company, or that effects or will effect a change to the Shares, the Company
shall notify the Depositary and the Custodian of that action or decision as soon as it is lawful and practical to give that notice.
The notice shall be in English and shall include all details that the Company is required to include in any notice to any governmental
or regulatory authority or securities exchange or is required to make available generally to holders of Shares by publication or
otherwise.
The Company will arrange
for the translation into English, if not already in English, to the extent required pursuant to any regulations of the Commission,
and the prompt transmittal by the Company to the Depositary and the Custodian of all notices and any other reports and communications
which are made generally available by the Company to holders of its Shares. If requested in writing by the Company, the Depositary
will Disseminate, at the Company’s expense, those notices, reports and communications to all Owners or otherwise make them
available to Owners in a manner that the Company specifies as substantially equivalent to the manner in which those communications
are made available to holders of Shares and compliant with the requirements of any securities exchange on which the American Depositary
Shares are listed. The Company will timely provide the Depositary with the quantity of such notices, reports, and communications,
as requested by the Depositary from time to time, in order for the Depositary to effect that Dissemination.
The Company represents
that as of the date of this Deposit Agreement, the statements in Article 11 of the Receipt with respect to the Company’s
obligation to file periodic reports under the United States Securities Exchange Act of 1934, as amended, are true and correct.
The Company agrees to promptly notify the Depositary upon becoming aware of any change in the truth of any of those statements.
SECTION 5.7.
Distribution
of Additional Shares, Rights, etc.
If the Company or any
affiliate of the Company determines to make any issuance or distribution of (1) additional Shares, (2) rights to subscribe
for Shares, (3) securities convertible into Shares, or (4) rights to subscribe for such securities (each a “
Distribution
”),
the Company shall notify the Depositary in writing in English as promptly as practicable and in any event before the Distribution
starts and, if requested in writing by the Depositary, the Company shall promptly furnish to the Depositary either (i) evidence
reasonably satisfactory to the Depositary that the Distribution is registered under the Securities Act of 1933 or (ii) a written
opinion from U.S. counsel for the Company that is reasonably satisfactory to the Depositary, stating that the Distribution does
not require, or, if made in the United States, would not require, registration under the Securities Act of 1933.
The Company agrees with
the Depositary that neither the Company nor any company controlled by, controlling or under common control with the Company will
at any time deposit any Shares that, at the time of deposit, are Restricted Securities.
Nothing in this Deposit
Agreement shall create any obligation on the part of the Company to file a registration statement under the Securities Act of 1933
with respect to any Distribution. To the extent the Company in its sole discretion deems it necessary or advisable in order to
avoid any requirement to register securities under the Securities Act of 1933, it may prevent Owners in the United States from
purchasing securities and may instruct the Depositary not to accept certain Shares reasonably identified in such instruction for
deposit for such period of time following the issuance of such additional securities or to adopt such other specific measures as
the Company may reasonably request.
SECTION 5.8.
Indemnification.
The Company agrees to
indemnify the Depositary, its directors, employees, agents and affiliates and each Custodian against, and hold each of them harmless
from, any liability or expense (including, but not limited to any fees and expenses incurred in seeking, enforcing or collecting
such indemnity and the reasonable fees and expenses of counsel) that may arise out of or in connection with (a) any registration
with the Commission of American Depositary Shares or Deposited Securities or the offer or sale thereof in the United States or
(b) acts performed or omitted, pursuant to the provisions of or in connection with this Deposit Agreement and the American Depositary
Shares, as the same may be amended, modified or supplemented from time to time, (i) by either the Depositary or a Custodian or
their respective directors, employees, agents and affiliates, except for any liability or expense arising out of the negligence
or bad faith of either of them, or (ii) by the Company or any of its directors, employees, agents and affiliates.
The indemnities contained
in the preceding paragraph shall not extend to any Losses arising out of information relating to the Depositary or any Custodian,
as the case may be, furnished in writing by the Depositary to the Company expressly for use in any registration statement, proxy
statement, prospectus or preliminary prospectus or any other offering documents relating to the American Depositary Share, the
Shares or any other Deposited Securities (it being acknowledged that, as of the date of this Deposit Agreement, the Depositary
has not furnished any information of that kind).
The Depositary agrees
to indemnify the Company, its directors, employees, agents and affiliates and hold them harmless from any liability or expense
that may arise out of acts performed or omitted by the Depositary or any Custodian or their respective directors, employees, agents
and affiliates due to their negligence or bad faith.
SECTION 5.9.
Charges
of Depositary.
The following charges
shall be incurred by any party depositing or withdrawing Shares or by any party surrendering American Depositary Shares or to whom
American Depositary Shares are issued (including, without limitation, issuance pursuant to a stock dividend or stock split declared
by the Company or an exchange of stock regarding the American Depositary Shares or Deposited Securities or a delivery of American
Depositary Shares pursuant to Section 4.3), or by Owners, as applicable: (1) taxes and other governmental charges, (2) such registration
fees as may from time to time be in effect for the registration of transfers of Shares generally on the Share register of the Company
or Foreign Registrar and applicable to transfers of Shares to or from the name of the Depositary or its nominee or the Custodian
or its nominee on the making of deposits or withdrawals hereunder, (3) such cable (including SWIFT) and facsimile transmission
fees and expenses as are expressly provided in this Deposit Agreement, (4) such expenses as are incurred by the Depositary in the
conversion of foreign currency pursuant to Section 4.5, (5) a fee of $5.00 or less per 100 American Depositary Shares (or portion
thereof) for the delivery of American Depositary Shares pursuant to Section 2.3, 4.3 or 4.4 and the surrender of American Depositary
Shares pursuant to Section 2.5 or 6.2, (6) a fee of $.05 or less per American Depositary Share (or portion thereof) for any cash
distribution made pursuant to this Deposit Agreement, including, but not limited to Sections 4.1 through 4.4 and Section 4.8, (7)
a fee for the distribution of securities pursuant to Section 4.2 or of rights pursuant to Section 4.4 (where the Depositary will
not exercise or sell those rights on behalf of Owners), such fee being in an amount equal to the fee for the execution and delivery
of American Depositary Shares referred to above which would have been charged as a result of the deposit of such securities under
this Deposit Agreement (for purposes of this item 7 treating all such securities as if they were Shares) but which securities are
instead distributed by the Depositary to Owners, (8) in addition to any fee charged under item 6 above, a fee of $.05 or less per
American Depositary Share (or portion thereof) per annum for depositary services, which will be payable as provided in item 9 below,
and (9) any other charges payable by the Depositary or the Custodian, any of the Depositary's or Custodian’s agents or the
agents of the Depositary's or Custodian’s agents, in connection with the servicing of Shares or other Deposited Securities
(which charges shall be assessed against Owners as of the date or dates set by the Depositary in accordance with Section 4.6 and
shall be payable at the sole discretion of the Depositary by billing those Owners for those charges or by deducting those charges
from one or more cash dividends or other cash distributions).
The Depositary may collect
any of its fees by deduction from any cash distribution payable, or by selling a portion of any securities to be distributed, to
Owners that are obligated to pay those fees.
In performing its duties
under this Deposit Agreement, the Depositary may use brokers, dealers, foreign currency dealers or other service providers that
are owned by or affiliated with the Depositary and that may earn or share fees, spreads or commissions.
The Depositary may own
and deal in any class of securities of the Company and its affiliates and in American Depositary Shares.
SECTION 5.10.
Retention
of Depositary Documents.
The Depositary is authorized
to destroy those documents, records, bills and other data compiled during the term of this Deposit Agreement at the times permitted
by the laws or regulations governing the Depositary, unless the Company requests that such papers be retained for a longer period
or turned over to the Company or to a successor depositary.
SECTION 5.11.
Exclusivity.
Without prejudice to
the Company’s rights under Section 5.4, the Company agrees not to appoint any other depositary for issuance of depositary
shares, depositary receipts or any similar securities or instruments so long as The Bank of New York Mellon is acting as Depositary
under this Deposit Agreement.
SECTION 5.12.
Information
for Regulatory Compliance.
Each of the Company and
the Depositary shall provide to the other, as promptly as practicable, information from its records or otherwise available to it
that is reasonably requested by the other to permit the other to comply with applicable law or requirements of governmental or
regulatory authorities.
ARTICLE 6. AMENDMENT
AND TERMINATION
SECTION 6.1.
Amendment.
The form of the Receipts
and any provisions of this Deposit Agreement may at any time and from time to time be amended by agreement between the Company
and the Depositary without the consent of Owners or Holders in any respect that they may deem necessary or desirable. Any amendment
that would impose or increase any fees or charges (other than taxes and other governmental charges, registration fees, cable, telex
or facsimile transmission costs, delivery costs or other such expenses), or that would otherwise prejudice any substantial existing
right of Owners, shall, however, not become effective as to outstanding American Depositary Shares until the expiration of 30 days
after notice of that amendment has been Disseminated to the Owners of outstanding American Depositary Shares. Every Owner and Holder,
at the time any amendment so becomes effective, shall be deemed, by continuing to hold American Depositary Shares or any interest
therein, to consent and agree to that amendment and to be bound by this Deposit Agreement as amended thereby. Upon the effectiveness
of an amendment to the form of Receipt, including a change in the number of Shares represented by each American Depositary Share,
the Depositary may call for surrender of Receipts to be replaced with new Receipts in the amended form or call for surrender of
American Depositary Shares to effect that change of ratio. In no event shall any amendment impair the right of the Owner to surrender
American Depositary Shares and receive delivery of the Deposited Securities represented thereby, except in order to comply with
mandatory provisions of applicable law.
Notwithstanding the foregoing,
if any governmental body should adopt new laws, rules or regulations which would require an amendment of this Deposit Agreement
to ensure compliance therewith, the Company and the Depositary may amend this Deposit Agreement at any time in accordance with
such changed laws, rules and regulations. Such amendment to this Deposit Agreement in such circumstances may become effective before
a notice of such amendment or supplement is given to Owners or within any other period of time as required for compliance with
such laws, rules or regulations.
SECTION 6.2.
Termination.
(a) The
Company may initiate termination of this Deposit Agreement by notice to the Depositary. The Depositary may initiate termination
of this Deposit Agreement if (i) at any time 90 days shall have expired after the Depositary delivered to the Company a written
resignation notice and a successor depositary has not been appointed and accepted its appointment as provided in Section 5.4, (ii)
an Insolvency Event or Delisting Event occurs with respect to the Company or (iii) a Termination Option Event has occurred or will
occur. If termination of this Deposit Agreement is initiated, the Depositary shall Disseminate a notice of termination to the Owners
of all American Depositary Shares then outstanding setting a date for termination (the “
Termination Date
”),
which shall be at least 90 days after the date of that notice, and this Deposit Agreement shall terminate on that Termination Date.
(b) After
the Termination Date, the Company shall be discharged from all obligations under this Deposit Agreement except for its obligations
to the Depositary under Sections 5.8 and 5.9.
(c) At
any time after the Termination Date, the Depositary may sell the Deposited Securities then held under this Deposit Agreement and
may thereafter hold uninvested the net proceeds of any such sale, together with any other cash then held by it hereunder, unsegregated
and without liability for interest, for the pro rata benefit of the Owners of American Depositary Shares that remain outstanding,
and those Owners will be general creditors of the Depositary with respect to those net proceeds and that other cash. After making
that sale, the Depositary shall be discharged from all obligations under this Deposit Agreement,
except
(i) to account for
the net proceeds and other cash (after deducting, in each case, the fee of the Depositary for the surrender of American Depositary
Shares, any expenses for the account of the Owner of such American Depositary Shares in accordance with the terms and conditions
of this Deposit Agreement and any applicable taxes or governmental charges) and (ii) for its obligations under Section 5.8 and
(iii) to act as provided in paragraph (d) below.
(d) After
the Termination Date, if any American Depositary Shares remain outstanding, the Depositary shall continue to receive dividends
and other distributions pertaining to Deposited Securities (that have not been sold), may sell rights and other property as provided
in this Deposit Agreement and shall deliver Deposited Securities (or sale proceeds) upon surrender of American Depositary Shares
(after payment or upon deduction, in each case, of the fee of the Depositary for the surrender of American Depositary Shares, any
expenses for the account of the Owner of those American Depositary Shares in accordance with the terms and conditions of this Deposit
Agreement and any applicable taxes or governmental charges). After the Termination Date, the Depositary shall not accept deposits
of Shares or deliver American Depositary Shares. After the Termination Date, (i) the Depositary may refuse to accept surrenders
of American Depositary Shares for the purpose of withdrawal of Deposited Securities (that have not been sold) or reverse previously
accepted surrenders of that kind that have not settled if in its judgment the requested withdrawal would interfere with its efforts
to sell the Deposited Securities, (ii) the Depositary will not be required to deliver cash proceeds of the sale of Deposited Securities
until all Deposited Securities have been sold and (iii) the Depositary may discontinue the registration of transfers of American
Depositary Shares and suspend the distribution of dividends and other distributions on Deposited Securities to the Owners and need
not give any further notices or perform any further acts under this Deposit Agreement except as provided in this Section.
ARTICLE 7. MISCELLANEOUS
SECTION 7.1.
Counterparts;
Signatures.
This Deposit Agreement
may be executed in any number of counterparts, each of which shall be deemed an original and all of those counterparts shall constitute
one and the same instrument. Copies of this Deposit Agreement shall be filed with the Depositary and the Custodians and shall be
open to inspection by any Owner or Holder during regular business hours.
Any manual signature
on this Deposit Agreement that is faxed, scanned or photocopied, and any electronic signature valid under the Electronic Signatures
in Global and National Commerce Act, 15 U.S.C. § 7001,
et. seq
., shall for all purposes have the same validity, legal
effect and admissibility in evidence as an original manual signature, and the parties hereby waive any objection to the contrary.
SECTION 7.2.
No
Third Party Beneficiaries.
This Deposit Agreement
is for the exclusive benefit of the Company, the Depositary, the Owners and the Holders and their respective successors and shall
not be deemed to give any legal or equitable right, remedy or claim whatsoever to any other person.
SECTION 7.3.
Severability.
In case any one or more
of the provisions contained in this Deposit Agreement or in a Receipt should be or become invalid, illegal or unenforceable in
any respect, the validity, legality and enforceability of the remaining provisions contained in this Deposit Agreement or that
Receipt shall in no way be affected, prejudiced or disturbed thereby.
SECTION 7.4.
Owners
and Holders as Parties; Binding Effect.
The Owners and Holders
from time to time shall be parties to this Deposit Agreement and shall be bound by all of the terms and conditions of this Deposit
Agreement and of the Receipts by acceptance of American Depositary Shares or any interest therein.
SECTION 7.5.
Notices.
Any and all notices to
be given to the Company shall be in writing and shall be deemed to have been duly given if personally delivered or sent by domestic
first class or international air mail or air courier or sent by facsimile transmission or email attaching a pdf or similar bit-mapped
image of a signed writing,
provided
that receipt of the facsimile transmission or email has been confirmed by the recipient,
addressed to Anchiano Therapeutics Ltd., 1/3 High-Tech Village, Givat Ram, Jerusalem, Israel, Attention: Jonathan Burgin, or any
other place to which the Company may have transferred its principal office with notice to the Depositary, with a copy to Mayer
Brown LLP, 1221 Avenue of the Americas, New York, New York 10020, Attention: Anna T. Pinedo.
Any and all notices to
be given to the Depositary shall be in writing and shall be deemed to have been duly given if in English and personally delivered
or sent by first class domestic or international air mail or air courier or sent by facsimile transmission or email attaching a
pdf or similar bit-mapped image of a signed writing, addressed to The Bank of New York Mellon, 240 Greenwich Street, New York,
New York 10286, Attention: Depositary Receipt Administration, or any other place to which the Depositary may have transferred
its Office with notice to the Company.
Delivery of a notice
to the Company or Depositary by mail or air courier shall be deemed effected when deposited, postage prepaid, in a post-office
letter box or received by an air courier service. Delivery of a notice to the Company or Depositary sent by facsimile transmission
or email shall be deemed effected when the recipient acknowledges receipt of that notice.
A notice to be given
to an Owner shall be deemed to have been duly given when Disseminated to that Owner. Dissemination in paper form will be effective
when personally delivered or sent by first class domestic or international air mail or air courier, addressed to that Owner at
the address of that Owner as it appears on the transfer books for American Depositary Shares of the Depositary, or, if that Owner
has filed with the Depositary a written request that notices intended for that Owner be mailed to some other address, at the address
designated in that request. Dissemination in electronic form will be effective when sent in the manner consented to by the Owner
to the electronic address most recently provided by the Owner for that purpose.
SECTION 7.6.
Appointment
of Agent for Service of Process; Submission to Jurisdiction; Jury Trial Waiver.
The Company hereby (i)
designates and appoints the person named in Exhibit A to this Deposit Agreement, located in the United States, as the Company's
authorized agent upon which process may be served in any suit or proceeding arising out of or relating to the Shares or Deposited
Securities, the American Depositary Shares, the Receipts or this Deposit Agreement (a “Proceeding”), (ii) consents
and submits to the jurisdiction of any state or federal court in the State of New York in which any Proceeding may be instituted
and (iii) agrees that service of process upon said authorized agent shall be deemed in every respect effective service of process
upon the Company in any Proceeding. The Company agrees to deliver to the Depositary, upon the execution and delivery of this Deposit
Agreement, a written acceptance by the agent named in Exhibit A to this Deposit Agreement of its appointment as process agent.
The Company further agrees to take any and all action, including the filing of any and all such documents and instruments, as may
be necessary to continue that designation and appointment in full force and effect, or to appoint and maintain the appointment
of another process agent located in the United States as required above, and to deliver to the Depositary a written acceptance
by that agent of that appointment, for so long as any American Depositary Shares or Receipts remain outstanding or this Deposit
Agreement remains in force. In the event the Company fails to maintain the designation and appointment of a process agent in the
United States in full force and effect, the Company hereby waives personal service of process upon it and consents that a service
of process in connection with a Proceeding may be made by certified or registered mail, return receipt requested, directed to the
Company at its address last specified for notices under this Deposit Agreement, and service so made shall be deemed completed five
(5) days after the same shall have been so mailed.
EACH PARTY TO THIS DEPOSIT
AGREEMENT (INCLUDING, FOR AVOIDANCE OF DOUBT, EACH OWNER AND HOLDER) HEREBY IRREVOCABLY WAIVES, TO THE FULLEST EXTENT PERMITTED
BY APPLICABLE LAW, ANY RIGHT IT MAY HAVE TO A TRIAL BY JURY IN ANY SUIT, ACTION OR PROCEEDING AGAINST THE COMPANY AND/OR THE DEPOSITARY
DIRECTLY OR INDIRECTLY ARISING OUT OF OR RELATING TO THE SHARES OR OTHER DEPOSITED SECURITIES, THE AMERICAN DEPOSITARY SHARES OR
THE RECEIPTS, THIS DEPOSIT AGREEMENT OR ANY TRANSACTION CONTEMPLATED HEREIN OR THEREIN, OR THE BREACH HEREOF OR THEREOF, INCLUDING,
WITHOUT LIMITATION, ANY QUESTION REGARDING EXISTENCE, VALIDITY OR TERMINATION (WHETHER BASED ON CONTRACT, TORT OR ANY OTHER THEORY).
SECTION 7.7.
Waiver
of Immunities.
To the extent that the
Company or any of its properties, assets or revenues may have or may hereafter become entitled to, or have attributed to it, any
right of immunity, on the grounds of sovereignty or otherwise, from any legal action, suit or proceeding, from the giving of any
relief in any respect thereof, from setoff or counterclaim, from the jurisdiction of any court, from service of process, from attachment
upon or prior to judgment, from attachment in aid of execution or judgment, or from execution of judgment, or other legal process
or proceeding for the giving of any relief or for the enforcement of any judgment, in any jurisdiction in which proceedings may
at any time be commenced, with respect to its obligations, liabilities or any other matter under or arising out of or in connection
with the Shares or Deposited Securities, the American Depositary Shares, the Receipts or this Deposit Agreement, the Company, to
the fullest extent permitted by law, hereby irrevocably and unconditionally waives, and agrees not to plead or claim, any immunity
of that kind and consents to relief and enforcement as provided above.
SECTION 7.8.
Governing
Law.
This Deposit Agreement
and the Receipts shall be interpreted in accordance with and all rights hereunder and thereunder and provisions hereof and thereof
shall be governed by the laws of the State of New York.
IN WITNESS WHEREOF, ANCHIANO
THERAPEUTICS LTD. and THE BANK OF NEW YORK MELLON have duly executed this Deposit Agreement as of the day and year first set forth
above and all Owners and Holders shall become parties hereto upon acceptance by them of American Depositary Shares or any interest
therein.
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ANCHIANO THERAPEUTICS LTD.
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By:
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/s/
Dr. Frank G. Haluska
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Name: Dr. Frank G. Haluska
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Title: Chief Executive Officer
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THE BANK OF NEW YORK MELLON,
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as Depositary
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By:
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/s/ Robert Goad
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Name: Robert Goad
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Title: Managing Director
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EXHIBIT A
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AMERICAN DEPOSITARY SHARES
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(Each American Depositary Share represents
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five deposited Shares)
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THE BANK OF NEW YORK MELLON
AMERICAN DEPOSITARY RECEIPT
FOR ORDINARY SHARES OF
ANCHIANO THERAPEUTICS LTD.
(INCORPORATED UNDER THE LAWS OF ISRAEL)
The Bank of New York
Mellon, as depositary (hereinafter called the “Depositary”), hereby certifies that_________________________________________,
or registered assigns IS THE OWNER OF _____________________________
AMERICAN DEPOSITARY SHARES
representing deposited ordinary shares
(herein called “Shares”) of Anchiano Therapeutics Ltd., incorporated under the laws of Israel (herein called the “
Company
”).
At the date hereof, each American Depositary Share represents five Shares deposited or subject to deposit under the Deposit Agreement
(as such term is hereinafter defined) with a custodian for the Depositary (herein called the “
Custodian
”) that,
as of the date of the Deposit Agreement, was Bank Leumi and Bank Hapoalim located in Israel. The Depositary's Office and its principal
executive office are located at 240 Greenwich Street, New York, N.Y. 10286.
THE DEPOSITARY'S OFFICE ADDRESS IS
240 GREENWICH STREET, NEW YORK, N.Y. 10286
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1.
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THE DEPOSIT AGREEMENT.
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This American Depositary
Receipt is one of an issue (herein called “
Receipts
”), all issued and to be issued upon the terms and conditions
set forth in the Deposit Agreement dated as of February 14, 2019 (herein called the “
Deposit Agreement
”) among
the Company, the Depositary, and all Owners and Holders from time to time of American Depositary Shares issued thereunder, each
of whom by accepting American Depositary Shares agrees to become a party thereto and become bound by all the terms and conditions
thereof. The Deposit Agreement sets forth the rights of Owners and Holders and the rights and duties of the Depositary in respect
of the Shares deposited thereunder and any and all other securities, property and cash from time to time received in respect of
those Shares and held thereunder (those Shares, securities, property, and cash are herein called “
Deposited Securities
”).
Copies of the Deposit Agreement are on file at the Depositary's Office in New York City and at the office of the Custodian.
The statements made
on the face and reverse of this Receipt are summaries of certain provisions of the Deposit Agreement and are qualified by and subject
to the detailed provisions of the Deposit Agreement, to which reference is hereby made. Capitalized terms defined in the Deposit
Agreement and not defined herein shall have the meanings set forth in the Deposit Agreement.
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2.
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SURRENDER OF AMERICAN DEPOSITARY SHARES AND WITHDRAWAL
OF SHARES.
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Upon surrender of American
Depositary Shares for the purpose of withdrawal of the Deposited Securities represented thereby and payment of the fee of the Depositary
for the surrender of American Depositary Shares as provided in Section 5.9 of the Deposit Agreement and payment of all taxes and
governmental charges payable in connection with that surrender and withdrawal of the Deposited Securities, and subject to the terms
and conditions of the Deposit Agreement, the Owner of those American Depositary Shares shall be entitled to delivery (to the extent
delivery can then be lawfully and practicably made), to or as instructed by that Owner, of the amount of Deposited Securities at
the time represented by those American Depositary Shares,
but not
any money or other property as to which a record date
for distribution to Owners has passed (since money or other property of that kind will be delivered or paid on the scheduled payment
date to the Owner as of that record date),
and except that
the Depositary shall not be required to accept surrender of American
Depositary Shares for the purpose of withdrawal to the extent it would require delivery of a fraction of a Deposited Security.
The Depositary shall direct the Custodian with respect to delivery of Deposited Securities and may charge the surrendering Owner
a fee and its expenses for giving that direction by cable (including SWIFT) or facsimile transmission. If Deposited Securities
are delivered physically upon surrender of American Depositary Shares for the purpose of withdrawal, that delivery will be made
at the Custodian’s office,
except that
, at the request, risk and expense of the surrendering Owner, and for the account
of that Owner, the Depositary shall direct the Custodian to forward any cash or other property comprising, and forward a certificate
or certificates, if applicable, and other proper documents of title, if any, for, the Deposited Securities represented by the surrendered
American Depositary Shares to the Depositary for delivery at the Depositary’s Office or to another address specified in the
order received from the surrendering Owner.
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3.
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REGISTRATION OF TRANSFER OF AMERICAN DEPOSITARY SHARES;
COMBINATION AND SPLIT-UP OF RECEIPTS; INTERCHANGE OF CERTIFICATED AND UNCERTIFICATED AMERICAN DEPOSITARY SHARES.
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The Depositary, subject
to the terms and conditions of the Deposit Agreement, shall register a transfer of American Depositary Shares on its transfer books
upon (i) in the case of certificated American Depositary Shares, surrender of the Receipt evidencing those American Depositary
Shares, by the Owner or by a duly authorized attorney, properly endorsed or accompanied by proper instruments of transfer or (ii)
in the case of uncertificated American Depositary Shares, receipt from the Owner of a proper instruction (including, for the avoidance
of doubt, instructions through DRS and Profile as provided in Section 2.9 of that Agreement), and, in either case, duly stamped
as may be required by the laws of the State of New York and of the United States of America. Upon registration of a transfer, the
Depositary shall deliver the transferred American Depositary Shares to or upon the order of the person entitled thereto.
The Depositary, subject
to the terms and conditions of the Deposit Agreement, shall upon surrender of a Receipt or Receipts for the purpose of effecting
a split-up or combination of such Receipt or Receipts, execute and deliver a new Receipt or Receipts for any authorized number
of American Depositary Shares requested, evidencing the same aggregate number of American Depositary Shares as the Receipt or Receipts
surrendered.
The Depositary, upon
surrender of certificated American Depositary Shares for the purpose of exchanging for uncertificated American Depositary Shares,
shall cancel the Receipt evidencing those certificated American Depositary Shares and send the Owner a statement confirming that
the Owner is the owner of the same number of uncertificated American Depositary Shares. The Depositary, upon receipt of a proper
instruction (including, for the avoidance of doubt, instructions through DRS and Profile as provided in Section 2.9 of the Deposit
Agreement) from the Owner of uncertificated American Depositary Shares for the purpose of exchanging for certificated American
Depositary Shares, shall cancel those uncertificated American Depositary Shares and register and deliver to the Owner a Receipt
evidencing the same number of certificated American Depositary Shares.
As a condition precedent
to the delivery, registration of transfer, or surrender of any American Depositary Shares or split-up or combination of any Receipt
or withdrawal of any Deposited Securities, the Depositary, the Custodian, or Registrar may require payment from the depositor of
the Shares or the presenter of the Receipt or instruction for registration of transfer or surrender of American Depositary Shares
not evidenced by a Receipt of a sum sufficient to reimburse it for any tax or other governmental charge and any stock transfer
or registration fee with respect thereto (including any such tax or charge and fee with respect to Shares being deposited or withdrawn)
and payment of any applicable fees as provided in the Deposit Agreement, may require the production of proof satisfactory to it
as to the identity and genuineness of any signature and may also require compliance with any regulations the Depositary may establish
consistent with the provisions of the Deposit Agreement.
The delivery of American
Depositary Shares against deposit of Shares generally or against deposit of particular Shares may be suspended, or the registration
of transfer of American Depositary Shares in particular instances may be refused, or the registration of transfer of outstanding
American Depositary Shares generally may be suspended, during any period when the transfer books of the Depositary are closed,
or if any such action is deemed necessary or advisable by the Depositary or the Company at any time or from time to time because
of any requirement of law or of any government or governmental body or commission, or under any provision of the Deposit Agreement,
or for any other reason. Notwithstanding anything to the contrary in the Deposit Agreement or this Receipt, the surrender of outstanding
American Depositary Shares and withdrawal of Deposited Securities may not be suspended subject only to (i) temporary delays caused
by closing the transfer books of the Depositary or the Company or the Foreign Registrar, if applicable, or the deposit of Shares
in connection with voting at a shareholders’ meeting, or the payment of dividends, (ii) the payment of fees, taxes and similar
charges, and (iii) compliance with any U.S. or foreign laws or governmental regulations relating to the American Depositary Shares
or to the withdrawal of the Deposited Securities. The Depositary shall not knowingly accept for deposit under the Deposit Agreement
any Shares that, at the time of deposit, are Restricted Securities.
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4.
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LIABILITY OF OWNER FOR TAXES.
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If any tax or other
governmental charge shall become payable by the Custodian or the Depositary with respect to or in connection with any American
Depositary Shares or any Deposited Securities represented by any American Depositary Shares or in connection with a transaction
to which Section 4.8 of the Deposit Agreement applies, that tax or other governmental charge shall be payable by the Owner of those
American Depositary Shares to the Depositary. The Depositary may refuse to register any transfer of those American Depositary Shares
or any withdrawal of Deposited Securities represented by those American Depositary Shares until that payment is made, and may withhold
any dividends or other distributions or the proceeds thereof, or may sell for the account of the Owner any part or all of the Deposited
Securities represented by those American Depositary Shares, and may apply those dividends or other distributions or the net proceeds
of any sale of that kind in payment of that tax or other governmental charge but, even after a sale of that kind, the Owner shall
remain liable for any deficiency. The Depositary shall distribute any net proceeds of a sale made under Section 3.2 of the Deposit
Agreement that are not used to pay taxes or governmental charges to the Owners entitled to them in accordance with Section 4.1
of the Deposit Agreement. If the number of Shares represented by each American Depositary Share decreases as a result of a sale
of Deposited Securities under Section 3.2 of the Deposit Agreement, the Depositary may call for surrender of the American Depositary
Shares to be exchanged on a mandatory basis for a lesser number of American Depositary Shares and may sell American Depositary
Shares to the extent necessary to avoid distributing fractions of American Depositary Shares in that exchange and distribute the
net proceeds of that sale to the Owners entitled to them.
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5.
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WARRANTIES ON DEPOSIT OF SHARES.
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Every person depositing
Shares under the Deposit Agreement shall be deemed thereby to represent and warrant that those Shares and each certificate therefor,
if applicable, are validly issued, fully paid and nonassessable and were not issued in violation of any preemptive or similar rights
of the holders of outstanding securities of the Company and that the person making that deposit is duly authorized so to do. Every
depositing person shall also be deemed to represent that the Shares, at the time of deposit, are not Restricted Securities. All
representations and warranties deemed made under Section 3.3 of the Deposit Agreement shall survive the deposit of Shares and delivery
of American Depositary Shares.
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6.
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FILING PROOFS, CERTIFICATES, AND OTHER INFORMATION.
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Any person presenting
Shares for deposit or any Owner or Holder may be required from time to time to file with the Depositary or the Custodian such proof
of citizenship or residence, exchange control approval, or such information relating to the registration on the books of the Company
or the Foreign Registrar, if applicable, to execute such certificates and to make such representations and warranties, as the Depositary
may deem necessary or proper. The Depositary may withhold the delivery or registration of transfer of any American Depositary Shares,
the distribution of any dividend or other distribution or of the proceeds thereof or the delivery of any Deposited Securities until
that proof or other information is filed or those certificates are executed or those representations and warranties are made. As
conditions of accepting Shares for deposit, the Depositary may require (i) any certification required by the Depositary or the
Custodian in accordance with the provisions of the Deposit Agreement, (ii) a written order directing the Depositary to deliver
to, or upon the written order of, the person or persons stated in that order, the number of American Depositary Shares representing
those Deposited Shares, (iii) evidence satisfactory to the Depositary that those Shares have been re-registered in the books of
the Company or the Foreign Registrar in the name of the Depositary, a Custodian or a nominee of the Depositary or a Custodian,
(iv) evidence satisfactory to the Depositary that any necessary approval has been granted by any governmental body in each applicable
jurisdiction and (v) an agreement or assignment, or other instrument satisfactory to the Depositary, that provides for the prompt
transfer to the Custodian of any dividend, or right to subscribe for additional Shares or to receive other property, that any person
in whose name those Shares are or have been recorded may thereafter receive upon or in respect of those Shares, or, in lieu thereof,
such agreement of indemnity or other agreement as shall be satisfactory to the Depositary.
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7.
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CHARGES OF DEPOSITARY.
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The following charges
shall be incurred by any party depositing or withdrawing Shares or by any party surrendering American Depositary Shares or to whom
American Depositary Shares are issued (including, without limitation, issuance pursuant to a stock dividend or stock split declared
by the Company or an exchange of stock regarding the American Depositary Shares or Deposited Securities or a delivery of American
Depositary Shares pursuant to Section 4.3 of the Deposit Agreement), or by Owners, as applicable: (1) taxes and other governmental
charges, (2) such registration fees as may from time to time be in effect for the registration of transfers of Shares generally
on the Share register of the Company or Foreign Registrar and applicable to transfers of Shares to or from the name of the Depositary
or its nominee or the Custodian or its nominee on the making of deposits or withdrawals hereunder, (3) such cable (including SWIFT)
and facsimile transmission fees and expenses as are expressly provided in the Deposit Agreement, (4) such expenses as are incurred
by the Depositary in the conversion of foreign currency pursuant to Section 4.5 of the Deposit Agreement, (5) a fee of $5.00 or
less per 100 American Depositary Shares (or portion thereof) for the delivery of American Depositary Shares pursuant to Section
2.3, 4.3 or 4.4 of the Deposit Agreement and the surrender of American Depositary Shares pursuant to Section 2.5 or 6.2 of the
Deposit Agreement, (6) a fee of $.05 or less per American Depositary Share (or portion thereof) for any cash distribution made
pursuant to the Deposit Agreement, including, but not limited to Sections 4.1 through 4.4 and 4.8 of the Deposit Agreement, (7)
a fee for the distribution of securities pursuant to Section 4.2 of the Deposit Agreement or of rights pursuant to Section 4.4
of that Agreement (where the Depositary will not exercise or sell those rights on behalf of Owners), such fee being in an amount
equal to the fee for the execution and delivery of American Depositary Shares referred to above which would have been charged as
a result of the deposit of such securities under the Deposit Agreement (for purposes of this item 7 treating all such securities
as if they were Shares) but which securities are instead distributed by the Depositary to Owners, (8) in addition to any fee charged
under item 6, a fee of $.05 or less per American Depositary Share (or portion thereof) per annum for depositary services, which
will be payable as provided in item 9 below, and (9) any other charges payable by the Depositary or the Custodian, any of the Depositary's
or Custodian’s agents or the agents of the Depositary's or Custodian’s agents, in connection with the servicing of
Shares or other Deposited Securities (which charges shall be assessed against Owners as of the date or dates set by the Depositary
in accordance with Section 4.6 of the Deposit Agreement and shall be payable at the sole discretion of the Depositary by billing
those Owners for those charges or by deducting those charges from one or more cash dividends or other cash distributions).
The Depositary may
collect any of its fees by deduction from any cash distribution payable, or by selling a portion of any securities to be distributed,
to Owners that are obligated to pay those fees.
The Depositary may
own and deal in any class of securities of the Company and its affiliates and in American Depositary Shares.
From time to time,
the Depositary may make payments to the Company to reimburse the Company for costs and expenses generally arising out of establishment
and maintenance of the American Depositary Shares program, waive fees and expenses for services provided by the Depositary or share
revenue from the fees collected from Owners or Holders. In performing its duties under the Deposit Agreement, the Depositary may
use brokers, dealers, foreign currency dealers or other service providers that are owned by or affiliated with the Depositary and
that may earn or share fees, spreads or commissions.
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8.
|
DISCLOSURE OF INTERESTS.
|
When required in order
to comply with applicable laws and regulations or the articles of association or similar document of the Company, the Company may
from time to time request each Owner and Holder to provide to the Depositary information relating to: (a) the capacity in which
it holds American Depositary Shares, (b) the identity of any Holders or other persons or entities then or previously interested
in those American Depositary Shares and the nature of those interests and (c) any other matter where disclosure of such matter
is required for that compliance. Each Owner and Holder agrees to provide all information known to it in response to a request made
pursuant to Section 3.4 of the Deposit Agreement. Each Holder consents to the disclosure by the Depositary and the Owner or other
Holder through which it holds American Depositary Shares, directly or indirectly, of all information responsive to a request made
pursuant to that Section relating to that Holder that is known to that Owner or other Holder.
As of the date of the
Deposit Agreement, each Owner and Holder agrees, if it instructs the Depositary to exercise voting rights with respect to Deposited
Shares, that it will comply with any applicable Israeli law requiring it to, inter alia, disclose any personal interest it might
have in the matter on the agenda of the general meeting. The Company undertakes no obligations to update this Section to reflect
changes in law that occur after the date of the Deposit Agreement.
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9.
|
TITLE TO AMERICAN DEPOSITARY SHARES.
|
It is a condition of
the American Depositary Shares, and every successive Owner and Holder of American Depositary Shares, by accepting or holding the
same, consents and agrees that American Depositary Shares evidenced by a Receipt, when the Receipt is properly endorsed or accompanied
by proper instruments of transfer, shall be transferable as certificated registered securities under the laws of the State of New
York, and that American Depositary Shares not evidenced by Receipts shall be transferable as uncertificated registered securities
under the laws of the State of New York. The Depositary, notwithstanding any notice to the contrary, may treat the Owner of American
Depositary Shares as the absolute owner thereof for the purpose of determining the person entitled to distribution of dividends
or other distributions or to any notice provided for in the Deposit Agreement and for all other purposes, and neither the Depositary
nor the Company shall have any obligation or be subject to any liability under the Deposit Agreement to any Holder of American
Depositary Shares, but only to the Owner.
This Receipt shall
not be entitled to any benefits under the Deposit Agreement or be valid or obligatory for any purpose, unless this Receipt shall
have been (i) executed by the Depositary by the manual signature of a duly authorized officer of the Depositary or (ii) executed
by the facsimile signature of a duly authorized officer of the Depositary and countersigned by the manual signature of a duly authorized
signatory of the Depositary or the Registrar or a co-registrar.
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11.
|
REPORTS; INSPECTION OF TRANSFER BOOKS.
|
The Company is subject
to the periodic reporting requirements of the Securities Exchange Act of 1934 and, accordingly, files certain reports with the
Securities and Exchange Commission. Those reports will be available for inspection and copying through the Commission's EDGAR system
or at public reference facilities maintained by the Commission in Washington, D.C.
The Depositary will
make available for inspection by Owners at its Office any reports, notices and other communications, including any proxy soliciting
material, received from the Company which are both (a) received by the Depositary as the holder of the Deposited Securities
and (b) made generally available to the holders of those Deposited Securities by the Company. The Company shall furnish reports
and communications, including any proxy soliciting material to which Section 4.9 of the Deposit Agreement applies, to the Depositary
in English, to the extent such materials are required to be translated into English pursuant to any regulations of the Commission.
The Depositary will
keep books for the registration of American Depositary Shares and transfers of American Depositary Shares, which shall be open
for inspection by the Owners at the Depositary’s Office during regular business hours,
provided
that such inspection
shall not be for the purpose of communicating with Owners in the interest of a business or object other than the business of the
Company or a matter related to the Deposit Agreement or the American Depositary Shares.
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12.
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DIVIDENDS AND DISTRIBUTIONS.
|
Whenever the Depositary
receives any cash dividend or other cash distribution on Deposited Securities, the Depositary will, if at the time of receipt thereof
any amounts received in a foreign currency can in the judgment of the Depositary be converted on a reasonable basis into Dollars
transferable to the United States, and subject to the Deposit Agreement, convert that dividend or other cash distribution into
Dollars and distribute the amount thus received (net of the fees and expenses of the Depositary as provided in Article 7 hereof
and Section 5.9 of the Deposit Agreement) to the Owners entitled thereto;
provided
,
however
, that if the Custodian
or the Depositary is required to withhold and does withhold from that cash dividend or other cash distribution an amount on account
of taxes or other governmental charges, the amount distributed to the Owners of the American Depositary Shares representing those
Deposited Securities shall be reduced accordingly. If a cash distribution would represent a return of all or substantially all
the value of the Deposited Securities underlying American Depositary Shares, the Depositary may require surrender of those American
Depositary Shares and may require payment of or deduct the fee for surrender of American Depositary Shares (whether or not it is
also requiring surrender of American Depositary Shares) as a condition of making that cash distribution. A distribution of that
kind shall be a
Termination Option Event
.
Subject to the provisions
of Section 4.11 and 5.9 of the Deposit Agreement, whenever the Depositary receives any distribution other than a distribution
described in Section 4.1, 4.3 or 4.4 of the Deposit Agreement on Deposited Securities (but not in exchange for or in conversion
or in lieu of Deposited Securities), the Depositary will cause the securities or property received by it to be distributed to the
Owners entitled thereto, after deduction or upon payment of any fees and expenses of the Depositary and any taxes or other governmental
charges, in any manner that the Depositary deems equitable and practicable for accomplishing that distribution (which may be a
distribution of depositary shares representing the securities received);
provided
,
however
, that if in the opinion
of the Depositary such distribution cannot be made proportionately among the Owners of Receipts entitled thereto, or if for any
other reason the Depositary deems such distribution not to be lawful and feasible, the Depositary may adopt such other method as
it may deem equitable and practicable for the purpose of effecting such distribution, including, but not limited to, the public
or private sale of the securities or property thus received, or any part thereof, and distribution of the net proceeds of any such
sale (net of the fees and expenses of the Depositary as provided in Article 7 hereof and Section 5.9 of the Deposit Agreement)
to the Owners entitled thereto all in the manner and subject to the conditions set forth in Section 4.1 of the Deposit Agreement.
The Depositary may withhold any distribution of securities under Section 4.2 of the Deposit Agreement if it has not received satisfactory
assurances from the Company that the distribution does not require registration under the Securities Act of 1933. The Depositary
may sell, by public or private sale, an amount of securities or other property it would otherwise distribute under this Article
that is sufficient to pay its fees and expenses in respect of that distribution. If a distribution under Section 4.2 of the Deposit
Agreement would represent a return of all of substantially all the value of the Deposited Securities underlying American Depositary
Shares, the Depositary may require surrender of those American Depositary Shares and may require payment of or deduct the fee for
surrender of American Depositary Shares (whether or not it is also requiring surrender of American Depositary Shares) as a condition
of making that distribution. A distribution of that kind shall be a
Termination Option Event
.
Whenever the Depositary
receives any distribution consisting of a dividend in, or free distribution of, Shares, the Depositary may deliver to the Owners
entitled thereto, an aggregate number of American Depositary Shares representing the amount of Shares received as that dividend
or free distribution, subject to the terms and conditions of the Deposit Agreement with respect to the deposit of Shares and issuance
of American Depositary Shares, including the withholding of any tax or other governmental charge as provided in Section 4.11 of
the Deposit Agreement and the payment of the fees and expenses of the Depositary as provided in Article 7 hereof and Section 5.9
of the Deposit Agreement (and the Depositary may sell, by public or private sale, an amount of Shares received (or American Depositary
Shares representing those Shares) sufficient to pay its fees and expenses in respect of that distribution). In lieu of delivering
fractional American Depositary Shares, the Depositary may sell the amount of Shares represented by the aggregate of those fractions
(or American Depositary Shares representing those Shares) and distribute the net proceeds, all in the manner and subject to the
conditions described in Section 4.1of the Deposit Agreement. If and to the extent that additional American Depositary Shares are
not delivered and Shares or American Depositary Shares are not sold, each American Depositary Share shall thenceforth also represent
the additional Shares distributed on the Deposited Securities represented thereby.
If the Company declares
a distribution in which holders of Deposited Securities have a right to elect whether to receive cash, Shares or other securities
or a combination of those things, or a right to elect to have a distribution sold on their behalf, the Depositary may, after consultation
with the Company, make that right of election available for exercise by Owners any manner the Depositary considers to be lawful
and practical. As a condition of making a distribution election right available to Owners, the Depositary may require satisfactory
assurances from the Company that doing so does not require registration of any securities under the Securities Act of 1933.
If the Depositary determines
that any distribution received or to be made by the Depositary (including Shares and rights to subscribe therefor) is subject to
any tax or other governmental charge that the Depositary is obligated to withhold, the Depositary may sell, by public or private
sale, all or a portion of the distributed property (including Shares and rights to subscribe therefor) in the amounts and manner
the Depositary deems necessary and practicable to pay any those taxes or charges, and the Depositary shall distribute the net proceeds
of that sale, after deduction of those taxes or charges, to the Owners entitled thereto in proportion to the number of American
Depositary Shares held by them respectively.
Each Owner and Holder
agrees to indemnify the Company, the Depositary, the Custodian and their respective directors, employees, agents and affiliates
for, and hold each of them harmless against, any claim by any governmental authority with respect to taxes, additions to tax, penalties
or interest arising out of any refund of taxes, reduced withholding at source or other tax benefit received by it. Services for
Owners and Holders that may permit them to obtain reduced rates of tax withholding at source or reclaim excess tax withheld, and
the fees and costs associated with using services of that kind, are not provided under, and are outside the scope of, the Deposit
Agreement.
(a) If
rights are granted to the Depositary in respect of deposited Shares to purchase additional Shares or other securities, the Company
and the Depositary shall endeavor to consult as to the actions, if any, the Depositary should take in connection with that grant
of rights. The Depositary may, to the extent deemed by it to be lawful and practical (i) if requested in writing by the Company,
grant to all or certain Owners rights to instruct the Depositary to purchase the securities to which the rights relate and deliver
those securities or American Depositary Shares representing those securities to Owners, (ii) if requested in writing by the Company,
deliver the rights to or to the order of certain Owners, or (iii) sell the rights to the extent practicable and distribute the
net proceeds of that sale to Owners entitled to those proceeds. To the extent rights are not exercised, delivered or disposed of
under (i), (ii) or (iii) above, the Depositary shall permit the rights to lapse unexercised.
(b) If
the Depositary will act under (a)(i) above, the Company and the Depositary will enter into a separate agreement setting forth the
conditions and procedures applicable to the particular offering. Upon instruction from an applicable Owner in the form the Depositary
specified and upon payment by that Owner to the Depositary of an amount equal to the purchase price of the securities to be received
upon the exercise of the rights, the Depositary shall, on behalf of that Owner, exercise the rights and purchase the securities.
The purchased securities shall be delivered to, or as instructed by, the Depositary. The Depositary shall (i) deposit the purchased
Shares under the Deposit Agreement and deliver American Depositary Shares representing those Shares to that Owner or (ii) deliver
or cause the purchased Shares or other securities to be delivered to or to the order of that Owner. The Depositary will not act
under (a)(i) above unless the offer and sale of the securities to which the rights relate are registered under the Securities Act
of 1933 or the Depositary has received an opinion of United States counsel that is satisfactory to it to the effect that those
securities may be sold and delivered to the applicable Owners without registration under the Securities Act of 1933.
(c) If
the Depositary will act under (a)(ii) above, the Company and the Depositary will enter into a separate agreement setting forth
the conditions and procedures applicable to the particular offering. Upon (i) the request of an applicable Owner to deliver the
rights allocable to the American Depositary Shares of that Owner to an account specified by that Owner to which the rights can
be delivered and (ii) receipt of such documents as the Company and the Depositary agreed to require to comply with applicable law,
the Depositary will deliver those rights as requested by that Owner.
(d) If
the Depositary will act under (a)(iii) above, the Depositary will use reasonable efforts to sell the rights in proportion to the
number of American Depositary Shares held by the applicable Owners and pay the net proceeds to the Owners otherwise entitled to
the rights that were sold, upon an averaged or other practical basis without regard to any distinctions among such Owners because
of exchange restrictions or the date of delivery of any American Depositary Shares or otherwise.
(e) Payment
or deduction of the fees of the Depositary as provided in Section 5.9 of the Deposit Agreement and payment or deduction of the
expenses of the Depositary and any applicable taxes or other governmental charges shall be conditions of any delivery of securities
or payment of cash proceeds under Section 4.4 of that Agreement.
(f) The
Depositary shall not be responsible for any failure to determine that it may be lawful or feasible to make rights available to
or exercise rights on behalf of Owners in general or any Owner in particular, or to sell rights.
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14.
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CONVERSION OF FOREIGN CURRENCY.
|
Whenever the Depositary
or the Custodian receives foreign currency, by way of dividends or other distributions or the net proceeds from the sale of securities,
property or rights, and if at the time of the receipt thereof the foreign currency so received can in the judgment of the Depositary
be converted on a reasonable basis into Dollars and the resulting Dollars transferred to the United States, the Depositary shall
convert or cause to be converted by sale or in any other manner that it may determine that foreign currency into Dollars, and those
Dollars shall be distributed to the Owners entitled thereto. A cash distribution may be made upon an averaged or other practicable
basis without regard to any distinctions among Owners based on exchange restrictions, the date of delivery of any American Depositary
Shares or otherwise and shall be net of any expenses of conversion into Dollars incurred by the Depositary as provided in Section 5.9
of the Deposit Agreement.
If a conversion of
foreign currency or the repatriation or distribution of Dollars can be effected only with the approval or license of any government
or agency thereof, the Depositary may, but will not be required to, file an application for that approval or license.
If the Depositary determines
that in its judgment any foreign currency received by the Depositary or the Custodian is not convertible on a reasonable basis
into Dollars transferable to the United States, or if any approval or license of any government or agency thereof that is required
for such conversion is not filed or sought by the Depositary or is not obtained within a reasonable period as determined by the
Depositary, the Depositary may distribute the foreign currency received by the Depositary to, or in its discretion may hold such
foreign currency uninvested and without liability for interest thereon for the respective accounts of, the Owners entitled to receive
the same.
If any conversion of
foreign currency, in whole or in part, cannot be effected for distribution to some of the Owners entitled thereto, the Depositary
may in its discretion make that conversion and distribution in Dollars to the extent practicable and permissible to the Owners
entitled thereto and may distribute the balance of the foreign currency received by the Depositary to, or hold that balance uninvested
and without liability for interest thereon for the account of, the Owners entitled thereto.
The Depositary may
convert currency itself or through any of its affiliates and, in those cases, acts as principal for its own account and not as
agent, advisor, broker or fiduciary on behalf of any other person and earns revenue, including, without limitation, transaction
spreads, that it will retain for its own account. The revenue is based on, among other things, the difference between the
exchange rate assigned to the currency conversion made under the Deposit Agreement and the rate that the Depositary or its affiliate
receives when buying or selling foreign currency for its own account. The Depositary makes no representation that the exchange
rate used or obtained in any currency conversion under the Deposit Agreement will be the most favorable rate that could be obtained
at the time or that the method by which that rate will be determined will be the most favorable to Owners, subject to the Depositary’s
obligations under Section 5.3 of that Agreement. The methodology used to determine exchange rates used in currency conversions
is available upon request.
Whenever a cash dividend,
cash distribution or any other distribution is made on Deposited Securities or rights to purchase Shares or other securities are
issued with respect to Deposited Securities (which rights will be delivered to or exercised or sold on behalf of Owners in accordance
with Section 4.4 of the Deposit Agreement) or the Depositary receives notice that a distribution or issuance of that kind will
be made, or whenever the Depositary receives notice that a meeting of holders of Shares will be held in respect of which the Company
has requested the Depositary to send a notice under Section 4.7 of the Deposit Agreement, or whenever the Depositary will assess
a fee or charge against the Owners, or whenever the Depositary causes a change in the number of Shares that are represented by
each American Depositary Share, or whenever the Depositary otherwise finds it necessary or convenient, the Depositary shall fix
a record date, which shall be the same as, or as near as practicable to, any corresponding record date set by the Company with
respect to Shares, (a) for the determination of the Owners (i) who shall be entitled to receive the benefit of that dividend or
other distribution or those rights, (ii) who shall be entitled to give instructions for the exercise of voting rights at that meeting,
(iii) who shall be responsible for that fee or charge or (iv) for any other purpose for which the record date was set, or (b) on
or after which each American Depositary Share will represent the changed number of Shares. Subject to the provisions of Sections
4.1 through 4.5 of the Deposit Agreement and to the other terms and conditions of the Deposit Agreement, the Owners on a record
date fixed by the Depositary shall be entitled to receive the amount distributable by the Depositary with respect to that dividend
or other distribution or those rights or the net proceeds of sale thereof in proportion to the number of American Depositary Shares
held by them respectively, to give voting instructions or to act in respect of the other matter for which that record date was
fixed, or be responsible for that fee or charge, as the case may be.
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16.
|
VOTING OF DEPOSITED SHARES.
|
(a) Upon
receipt of notice from the Company of any meeting of holders of Shares at which holders of Shares will be entitled to vote, if
requested in writing by the Company, the Depositary shall, as soon as practicable thereafter, Disseminate to the Owners a notice,
the form of which shall be prepared by the Depositary and approved by the Company, that shall contain (i) the information contained
in the notice of meeting received by the Depositary, (ii) a statement that the Owners as of the close of business on a specified
record date will be entitled, subject to any applicable provision of Israeli law and of the articles of association or similar
documents of the Company, to instruct the Depositary as to the exercise of the voting rights pertaining to the amount of Shares
represented by their respective American Depositary Shares, (iii) a statement as to the manner in which those instructions may
be given and (iv) the last date on which the Depositary will accept instructions (the “Instruction Cutoff Date”).
(b) Upon
the written request of an Owner of American Depositary Shares, as of the date of the request or, if a record date was specified
by the Depositary, as of that record date, received on or before any Instruction Cutoff Date established by the Depositary, the
Depositary may, and if the Depositary sent a notice under the preceding paragraph shall, endeavor, in so far as practicable, to
vote or cause to be voted the amount of deposited Shares represented by those American Depositary Shares in accordance with the
instructions set forth in that request. The Depositary shall not vote or attempt to exercise the right to vote that attaches to
the deposited Shares other than in accordance with instructions given by Owners and received by the Depositary.
(c) There
can be no assurance that Owners generally or any Owner in particular will receive the notice described in paragraph (a) above in
time to enable Owners to give instructions to the Depositary prior to the Instruction Cutoff Date.
(d) In
order to give Owners a reasonable opportunity to instruct the Depositary as to the exercise of voting rights relating to Shares,
if the Company will request the Depositary to Disseminate a notice under paragraph (a) above, the Company shall give the Depositary
notice of the meeting, details concerning the matters to be voted upon and copies of materials to be made available to holders
of Shares in connection with the meeting not less than 45 days prior to the meeting date.
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17.
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TENDER AND EXCHANGE OFFERS; REDEMPTION, REPLACEMENT OR
CANCELLATION OF DEPOSITED SECURITIES.
|
(a) The
Depositary shall not tender any Deposited Securities in response to any voluntary cash tender offer, exchange offer or similar
offer made to holders of Deposited Securities (a “
Voluntary Offer
”), except when instructed in writing to do
so by an Owner surrendering American Depositary Shares and subject to any conditions or procedures the Depositary may require.
(b) If
the Depositary receives a written notice that Deposited Securities have been redeemed for cash or otherwise purchased for cash
in a transaction that is mandatory and binding on the Depositary as a holder of those Deposited Securities (a “
Redemption
”),
the Depositary, at the expense of the Company, shall (i) if required, surrender Deposited Securities that have been redeemed to
the issuer of those securities or its agent on the redemption date, (ii) Disseminate a notice to Owners (A) notifying them of that
Redemption, (B) calling for surrender of a corresponding number of American Depositary Shares and (C) notifying them that the called
American Depositary Shares have been converted into a right only to receive the money received by the Depositary upon that Redemption
and those net proceeds shall be the Deposited Securities to which Owners of those converted American Depositary Shares shall be
entitled upon surrenders of those American Depositary Shares in accordance with Section 2.5 or 6.2 of the Deposit Agreement and
(iii) distribute the money received upon that Redemption to the Owners entitled to it upon surrender by them of called American
Depositary Shares in accordance with Section 2.5 of that Agreement (and, for the avoidance of doubt, Owners shall not be entitled
to receive that money under Section 4.1 of that Agreement). If the Redemption affects less than all the Deposited Securities, the
Depositary shall call for surrender a corresponding portion of the outstanding American Depositary Shares and only those American
Depositary Shares will automatically be converted into a right to receive the net proceeds of the Redemption. The Depositary shall
allocate the American Depositary Shares converted under the preceding sentence among the Owners pro-rata to their respective holdings
of American Depositary Shares immediately prior to the Redemption,
except that
the allocations may be adjusted so that no
fraction of a converted American Depositary Share is allocated to any Owner. A Redemption of all or substantially all of the Deposited
Securities shall be a
Termination Option Event
.
(c) If
the Depositary is notified of or there occurs any change in nominal value or any subdivision, combination or any other reclassification
of the Deposited Securities or any recapitalization, reorganization, sale of assets substantially as an entirety, merger or consolidation
affecting the issuer of the Deposited Securities or to which it is a party that is mandatory and binding on the Depositary as a
holder of Deposited Securities and, as a result, securities or other property have been or will be delivered in exchange, conversion,
replacement or in lieu of, Deposited Securities (a “
Replacement
”), the Depositary shall, if required, surrender
the old Deposited Securities affected by that Replacement of Shares and hold, as new Deposited Securities under the Deposit Agreement,
the new securities or other property delivered to it in that Replacement.
However
, the Depositary may elect to sell those
new Deposited Securities if in the opinion of the Depositary it is not lawful or not practical for it to hold those new Deposited
Securities under the Deposit Agreement because those new Deposited Securities may not be distributed to Owners without registration
under the Securities Act of 1933 or for any other reason, at public or private sale, at such places and on such terms as it deems
proper and proceed as if those new Deposited Securities had been Redeemed under paragraph (b) above. A Replacement shall be a
Termination
Option Event
.
(d) In
the case of a Replacement where the new Deposited Securities will continue to be held under the Deposit Agreement, the Depositary
may call for the surrender of outstanding Receipts to be exchanged for new Receipts specifically describing the new Deposited Securities
and the number of those new Deposited Securities represented by each American Depositary Share. If the number of Shares represented
by each American Depositary Share decreases as a result of a Replacement, the Depositary may call for surrender of the American
Depositary Shares to be exchanged on a mandatory basis for a lesser number of American Depositary Shares and may sell American
Depositary Shares to the extent necessary to avoid distributing fractions of American Depositary Shares in that exchange and distribute
the net proceeds of that sale to the Owners entitled to them.
(e) If
there are no Deposited Securities with respect to American Depositary Shares, including if the Deposited Securities are cancelled,
or the Deposited Securities with respect to American Depositary Shares become apparently worthless, the Depositary may call for
surrender of those American Depositary Shares or may cancel those American Depositary Shares, upon notice to Owners, and that condition
shall be a
Termination Option Event
.
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18.
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LIABILITY OF THE COMPANY AND DEPOSITARY.
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Neither the Depositary
nor the Company nor any of their respective directors, employees, agents or affiliates shall incur any liability to any Owner or
Holder:
(i) if by reason of
(A) any provision of any present or future law or regulation or other act of the government of the United States, any State of
the United States or any other state or jurisdiction, or of any governmental or regulatory authority or stock exchange; (B) (in
the case of the Depositary only) any provision, present or future, of the articles of association or similar document of the Company,
or by reason of any provision of any securities issued or distributed by the Company, or any offering or distribution thereof;
or (C) any event or circumstance, whether natural or caused by a person or persons, that is beyond the ability of the Depositary
or the Company, as the case may be, to prevent or counteract by reasonable care or effort (including, but not limited to earthquakes,
floods, severe storms, fires, explosions, war, terrorism, civil unrest, labor disputes or criminal acts; interruptions or malfunctions
of utility services, Internet or other communications lines or systems; unauthorized access to or attacks on computer systems or
websites; or other failures or malfunctions of computer hardware or software or other systems or equipment), the Depositary or
the Company is, directly or indirectly, prevented from, forbidden to or delayed in, or could be subject to any civil or criminal
penalty on account of doing or performing and therefore does not do or perform, any act or thing that, by the terms of the Deposit
Agreement or the Deposited Securities, it is provided shall be done or performed;
(ii) for any exercise
of, or failure to exercise, any discretion provided for in the Deposit Agreement (including any determination by the Depositary
to take, or not take, any action that the Deposit Agreement provides the Depositary may take);
(iii) for the inability
of any Owner or Holder to benefit from any distribution, offering, right or other benefit that is made available to holders of
Deposited Securities but is not, under the terms of the Deposit Agreement, made available to Owners or Holders; or
(iv) for any special,
consequential or punitive damages for any breach of the terms of the Deposit Agreement.
Where, by the terms
of a distribution to which Section 4.1, 4.2 or 4.3 of the Deposit Agreement applies, or an offering to which Section 4.4 of that
Agreement applies, or for any other reason, that distribution or offering may not be made available to Owners, and the Depositary
may not dispose of that distribution or offering on behalf of Owners and make the net proceeds available to Owners, then the Depositary
shall not make that distribution or offering available to Owners, and shall allow any rights, if applicable, to lapse.
Neither the Company
nor the Depositary assumes any obligation or shall be subject to any liability under the Deposit Agreement to Owners or Holders,
except that they agree to perform their obligations specifically set forth in the Deposit Agreement without negligence or bad faith.
The Depositary shall not be a fiduciary or have any fiduciary duty to Owners or Holders. The Depositary shall not be subject to
any liability with respect to the validity or worth of the Deposited Securities. Neither the Depositary nor the Company shall be
under any obligation to appear in, prosecute or defend any action, suit, or other proceeding in respect of any Deposited Securities
or in respect of the American Depositary Shares, on behalf of any Owner or Holder or other person. Neither the Depositary nor the
Company shall be liable for any action or non-action by it in reliance upon the advice of or information from legal counsel, accountants,
any person presenting Shares for deposit, any Owner or Holder, or any other person believed by it in good faith to be competent
to give such advice or information. Each of the Depositary and the Company may rely, and shall be protected in relying upon, any
written notice, request, direction or other document believed by it to be genuine and to have been signed or presented by the proper
party or parties. The Depositary shall not be liable for any acts or omissions made by a successor depositary whether in connection
with a previous act or omission of the Depositary or in connection with a matter arising wholly after the removal or resignation
of the Depositary, provided that in connection with the issue out of which such potential liability arises, the Depositary performed
its obligations without negligence or bad faith while it acted as Depositary. The Depositary shall not be liable for the acts or
omissions of any securities depository, clearing agency or settlement system in connection with or arising out of book-entry settlement
of American Depositary Shares or Deposited Securities or otherwise. In the absence of bad faith on its part, the Depositary shall
not be responsible for any failure to carry out any instructions to vote any of the Deposited Securities or for the manner in which
any such vote is cast or the effect of any such vote. The Depositary shall have no duty to make any determination or provide any
information as to the tax status of the Company or any liability for any tax consequences that may be incurred by Owners or Holders
as a result of owning or holding American Depositary Shares. The Depositary shall not be liable for the inability or failure of
an Owner or Holder to obtain the benefit of a foreign tax credit, reduced rate of withholding or refund of amounts withheld in
respect of tax or any other tax benefit. No disclaimer of liability under the United States federal securities laws is intended
by any provision of the Deposit Agreement.
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19.
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RESIGNATION AND REMOVAL OF THE DEPOSITARY; APPOINTMENT
OF SUCCESSOR CUSTODIAN.
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The Depositary may
at any time resign as Depositary under the Deposit Agreement by written notice of its election so to do delivered to the Company,
to become effective upon the appointment of a successor depositary and its acceptance of such appointment as provided in the Deposit
Agreement. The Depositary may at any time be removed by the Company by 120 days’ prior written notice of that removal, to
become effective upon the later of (i) the 120th day after delivery of the notice to the Depositary and (ii) the appointment of
a successor depositary and its acceptance of its appointment as provided in the Deposit Agreement. The Depositary in its discretion
may at any time appoint a substitute or additional custodian or custodians.
The form of the Receipts
and any provisions of the Deposit Agreement may at any time and from time to time be amended by agreement between the Company and
the Depositary without the consent of Owners or Holders in any respect which they may deem necessary or desirable. Any amendment
that would impose or increase any fees or charges (other than taxes and other governmental charges, registration fees, cable, telex
or facsimile transmission costs, delivery costs or other such expenses), or that would otherwise prejudice any substantial existing
right of Owners, shall, however, not become effective as to outstanding American Depositary Shares until the expiration of 30 days
after notice of that amendment has been Disseminated to the Owners of outstanding American Depositary Shares. Every Owner and Holder,
at the time any amendment so becomes effective, shall be deemed, by continuing to hold American Depositary Shares or any interest
therein, to consent and agree to that amendment and to be bound by the Deposit Agreement as amended thereby. Upon the effectiveness
of an amendment to the form of Receipt, including a change in the number of Shares represented by each American Depositary Share,
the Depositary may call for surrender of Receipts to be replaced with new Receipts in the amended form or call for surrender of
American Depositary Shares to effect that change of ratio. In no event shall any amendment impair the right of the Owner to surrender
American Depositary Shares and receive delivery of the Deposited Securities represented thereby, except in order to comply with
mandatory provisions of applicable law.
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21.
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TERMINATION OF DEPOSIT AGREEMENT.
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(a) The
Company may initiate termination of the Deposit Agreement by notice to the Depositary. The Depositary may initiate termination
of the Deposit Agreement if (i) at any time 60 days shall have expired after the Depositary delivered to the Company a written
resignation notice and a successor depositary has not been appointed and accepted its appointment as provided in Section 5.4 of
that Agreement, (ii) an Insolvency Event or Delisting Event occurs with respect to the Company or (iii) a Termination Option Event
has occurred or will occur. If termination of the Deposit Agreement is initiated, the Depositary shall Disseminate a notice of
termination to the Owners of all American Depositary Shares then outstanding setting a date for termination (the “
Termination
Date
”), which shall be at least 90 days after the date of that notice, and the Deposit Agreement shall terminate on that
Termination Date.
(b) After
the Termination Date, the Company shall be discharged from all obligations under the Deposit Agreement except for its obligations
to the Depositary under Sections 5.8 and 5.9 of that Agreement.
(c) At
any time after the Termination Date, the Depositary may sell the Deposited Securities then held under the Deposit Agreement and
may thereafter hold uninvested the net proceeds of any such sale, together with any other cash then held by it hereunder, unsegregated
and without liability for interest, for the pro rata benefit of the Owners of American Depositary Shares that remain outstanding,
and those Owners will be general creditors of the Depositary with respect to those net proceeds and that other cash. After making
that sale, the Depositary shall be discharged from all obligations under the Deposit Agreement, except (i) to account for the net
proceeds and other cash (after deducting, in each case, the fee of the Depositary for the surrender of American Depositary Shares,
any expenses for the account of the Owner of such American Depositary Shares in accordance with the terms and conditions of the
Deposit Agreement and any applicable taxes or governmental charges) and (ii) for its obligations under Section 5.8 of that Agreement
and (iii) to act as provided in paragraph (d) below.
(d) After
the Termination Date, the Depositary shall continue to receive dividends and other distributions pertaining to Deposited Securities
(that have not been sold), may sell rights and other property as provided in the Deposit Agreement and shall deliver Deposited
Securities (or sale proceeds) upon surrender of American Depositary Shares (after payment or upon deduction, in each case, of the
fee of the Depositary for the surrender of American Depositary Shares, any expenses for the account of the Owner of those American
Depositary Shares in accordance with the terms and conditions of the Deposit Agreement and any applicable taxes or governmental
charges). After the Termination Date, the Depositary shall not accept deposits of Shares or deliver American Depositary Shares.
After the Termination Date, (i) the Depositary may refuse to accept surrenders of American Depositary Shares for the purpose of
withdrawal of Deposited Securities (that have not been sold) or reverse previously accepted surrenders of that kind that have not
settled if in its judgment the requested withdrawal would interfere with its efforts to sell the Deposited Securities, (ii) the
Depositary will not be required to deliver cash proceeds of the sale of Deposited Securities until all Deposited Securities have
been sold and (iii) the Depositary may discontinue the registration of transfers of American Depositary Shares and suspend the
distribution of dividends and other distributions on Deposited Securities to the Owners and need not give any further notices or
perform any further acts under the Deposit Agreement except as provided in Section 6.2 of that Agreement.
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22.
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DTC DIRECT REGISTRATION SYSTEM AND PROFILE MODIFICATION
SYSTEM.
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(a) Notwithstanding
the provisions of Section 2.4 of the Deposit Agreement, the parties acknowledge that DTC’s Direct Registration System (“
DRS
”)
and Profile Modification System (“
Profile
”) apply to the American Depositary Shares upon acceptance thereof
to DRS by DTC. DRS is the system administered by DTC that facilitates interchange between registered holding of uncertificated
securities and holding of security entitlements in those securities through DTC and a DTC participant. Profile is a required feature
of DRS that allows a DTC participant, claiming to act on behalf of an Owner of American Depositary Shares, to direct the Depositary
to register a transfer of those American Depositary Shares to DTC or its nominee and to deliver those American Depositary Shares
to the DTC account of that DTC participant without receipt by the Depositary of prior authorization from the Owner to register
that transfer.
(b) In
connection with DRS/Profile, the parties acknowledge that the Depositary will not determine whether the DTC participant that is
claiming to be acting on behalf of an Owner in requesting registration of transfer and delivery described in paragraph (a) above
has the actual authority to act on behalf of that Owner (notwithstanding any requirements under the Uniform Commercial Code). For
the avoidance of doubt, the provisions of Sections 5.3 and 5.8 of the Deposit Agreement apply to the matters arising from the use
of the DRS/Profile. The parties agree that the Depositary’s reliance on and compliance with instructions received by the
Depositary through the DRS/Profile system and otherwise in accordance with the Deposit Agreement, shall not constitute negligence
or bad faith on the part of the Depositary.
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23.
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APPOINTMENT OF AGENT FOR SERVICE OF PROCESS; SUBMISSION
TO JURISDICTION; JURY TRIAL WAIVER; WAIVER OF IMMUNITIES.
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The Company has (i)
appointed Anchiano Therapeutics, Inc., which currently maintains an office at One Kendall Square, Building 600, Suite 6-106, Cambridge,
Massachusetts 02139, United States of America, as the Company's authorized agent upon which process may be served in any suit or
proceeding arising out of or relating to the Shares or Deposited Securities, the American Depositary Shares, the Receipts or this
Agreement, (ii) consented and submitted to the jurisdiction of any state or federal court in the State of New York in which any
such suit or proceeding may be instituted, and (iii) agreed that service of process upon said authorized agent shall be deemed
in every respect effective service of process upon the Company in any such suit or proceeding.
EACH PARTY TO THE DEPOSIT
AGREEMENT (INCLUDING, FOR AVOIDANCE OF DOUBT, EACH OWNER AND HOLDER) THEREBY IRREVOCABLY WAIVES, TO THE FULLEST EXTENT PERMITTED
BY APPLICABLE LAW, ANY RIGHT IT MAY HAVE TO A TRIAL BY JURY IN ANY SUIT, ACTION OR PROCEEDING AGAINST THE COMPANY AND/OR THE DEPOSITARY
DIRECTLY OR INDIRECTLY ARISING OUT OF OR RELATING TO THE SHARES OR OTHER DEPOSITED SECURITIES, THE AMERICAN DEPOSITARY SHARES OR
THE RECEIPTS, THE DEPOSIT AGREEMENT OR ANY TRANSACTION CONTEMPLATED HEREIN OR THEREIN, OR THE BREACH HEREOF OR THEREOF, INCLUDING
WITHOUT LIMITATION ANY QUESTION REGARDING EXISTENCE, VALIDITY OR TERMINATION (WHETHER BASED ON CONTRACT, TORT OR ANY OTHER THEORY).
To the extent that
the Company or any of its properties, assets or revenues may have or hereafter become entitled to, or have attributed to it, any
right of immunity, on the grounds of sovereignty or otherwise, from any legal action, suit or proceeding, from the giving of any
relief in any respect thereof, from setoff or counterclaim, from the jurisdiction of any court, from service of process, from attachment
upon or prior to judgment, from attachment in aid of execution or judgment, or other legal process or proceeding for the giving
of any relief or for the enforcement of any judgment, in any jurisdiction in which proceedings may at any time be commenced, with
respect to its obligations, liabilities or any other matter under or arising out of or in connection with the Shares or Deposited
Securities, the American Depositary Shares, the Receipts or the Deposit Agreement, the Company, to the fullest extent permitted
by law, hereby irrevocably and unconditionally waives, and agrees not to plead or claim, any such immunity and consents to such
relief and enforcement.
