Exhibit 10.1

FOURTH AMENDMENT TO OFFICE LEASE

AND ASSIGNMENT AND ASSUMPTION OF LEASE

THIS FOURTH AMENDMENT TO OFFICE LEASE AND ASSIGNMENT AND ASSUMPTION OF LEASE (the “Fourth Amendment”) is executed this 29 ^th day of March, 2018 (the “Effective Date”), by and between BLUE ASH LANDINGS ACQUISITION, LLC, an Ohio limited liability company (“Landlord”), and AERPIO PHARMACEUTICALS, INC., a Delaware corporation (“Tenant”).

W I T N E S S E T H :

WHEREAS, Duke Realty Ohio, an Indiana general partnership (“Duke”), and Akebia Therapeutics, Inc. a Delaware corporation, as tenant (the “Original Tenant”) entered into a certain Office Lease dated September 29, 2009 (the “Original Lease”), whereby Tenant leased from Landlord that certain premises known as Suite 510 (the “Original Leased Premises”) in an office building commonly known as Pfeiffer Place located at 10300 Alliance Road, Cincinnati, Ohio 45242; and

WHEREAS, the Original Lease was amended by that certain First Lease Amendment dated April 23, 2010 (the “First Amendment”) whereby the Original Leased Premises was substituted for that certain space located at Suite 420 consisting of 7,580 rentable square feet (the “Leased Premises”) in an office building commonly known as Landings II located at 9987 Carver Road, Blue Ash, Ohio 45242 (the “Building”) ; and

WHEREAS, on or about April 1, 2011, DP Landings Building II, LLC, a Delaware limited liability company (“DP”) purchased the Building from Duke; and

WHEREAS, the Original Tenant, Aerpio Therapeutics, Inc., a Delaware corporation (“Aerpio Therapeutics”) and DP executed a certain Second Amendment and Assignment and Assumption of Lease dated April 25, 2012 (the “Second Amendment”) which included, among other things, the assumption of the obligations under the Original Lease, as amended, by Tenant; and

WHEREAS, on or about May 1, 2013, DP changed its name to RT Landings Building II, LLC, a Delaware limited liability company (“RT”); and

WHEREAS, Aerpio Therapeutics and RT executed a certain Third Amendment to Office Lease dated February 27, 2015 (the “Third Amendment”), which included, among other things, the extension of the Lease Term. The Original Lease, as amended by the First Amendment, the Second Amendment and the Third Amendment shall be collectively referred to herein as the “Lease”; and

WHEREAS, on or about February 8, 2016, Landlord purchased the building from RT; and is the successor-in-interest to the Original Landlord under the Lease; and

WHEREAS, Aerpio Therapeutics converted into a limited liability company and became a wholly-owned subsidiary of Tenant; and

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WHEREAS, Aerpio Therapeutics desires to assign all of its right, title and interest in and to the Lease to Tenant, and Tenant desires to assume all of the obligations under the Lease; and

WHEREAS, Landlord and Tenant otherwise desire to amend certain provisions of the Lease, including extension of the Lease Term, as set forth herein.

NOW, THEREFORE, in consideration of the foregoing premises, the mutual covenants herein contained and each act performed hereunder by the parties, Landlord and Tenant hereby agree that the Lease is amended as follows:

1. Incorporation of Recitals . The above recitals are hereby incorporated into this Fourth Amendment as if fully set forth herein.

2. Assignment of Assumption of Lease . Aerpio hereby assigns all of its right, title and interest in and to the Lease to Tenant, and Tenant hereby accepts the assignment and assumption of the Lease and hereby assumes and agrees to be bound by all of the rights and obligations of Aerpio Therapeutics as tenant under the Lease and acknowledges that all provisions of the Lease remain in full force and effect. Tenant agrees to indemnify, defend and hold Aerpio Therapeutics harmless from and against any and all liabilities, claims, demands, damages and causes of action that may now or hereafter be made or asserted against Aerpio Therapeutics arising out of or related to the Lease, and arising or accruing prior to or on the date of this Fourth Amendment.

3. Amendment to Section  1.01 of Lease. Basic Lease Provisions and Definitions .

(a) Lease Term . The parties hereto acknowledge that the Lease Term is currently scheduled to expire June 30, 2018. Landlord and Tenant hereby agree that the Lease Term will hereby be extended by an additional thirty-seven (37) months. Accordingly, upon the Effective Date of this Fourth Amendment, the Lease Term will expire on July  31, 2021. Section 1.01(h) is hereby amended and modified to reflect such extended Lease Term.

(b) Minimum Annual Rent . During the extended Lease Term, the Minimum Annual Rent shall be as follows:

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Section 1.01(e) is hereby modified and amended to reflect such Monthly Rental Installments during the extended Lease Term.

(d) Brokers: Colliers International representing Landlord and Cushman & Wakefield representing Tenant.

(e) Address for payments and notices are as follows:

3. Condition of Leased Premises . Tenant acknowledges that neither Landlord nor any agent, contractor or employee of Landlord has made any representation or warranty of any kind with respect to the Leased Premises, specifically including, but not limited to, any representation or warranty of suitability or fitness of the Leased Premises for any particular purpose, except as expressly set forth in the Lease, as amended herein. Except as provided in Section 4 of this Fourth Amendment, Tenant accepts the Leased Premises in an “AS IS - WHERE IS” condition.”

4. Landlord Improvements . Landlord will perform or cause to be performed, at Landlord’s sole cost and expense, the improvements to the Leased Premises set forth on Exhibit A attached hereto (the “Landlord Improvements”). Landlord shall provide Tenant with a proposed schedule for the construction and installation of the Landlord Improvements and will

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notify Tenant of any material changes to the schedule. Tenant will reasonably cooperate with Landlord in connection with the performance of the Landlord Improvements and will not materially interfere with Landlord’s completion of the same; provided, however, Landlord hereby acknowledges Tenant will be occupying the Leased Premises during the completion of the Landlord Improvements and hereby agrees to make commercially reasonable efforts not to unreasonably interfere with Tenant’s use and occupancy of the Leased Premises. Landlord will use commercially reasonable efforts to substantially complete the Landlord Improvements by July 1, 2018, subject to force majeure (as defined in Section 16.03 of the Lease) and delays caused by Tenant.

5. Controllable Expenses . The parties acknowledge and agree that the cap on Controllable Expenses, as provided in Section 3.06, shall remain in place and in full force and effect during the extended Lease Term.

6. Renewal Option . Provided that no Event of Default exists beyond any applicable notice and cure period, then Tenant is hereby granted the option to renew the Lease Term for all, but not part of, the Leased Premises for one (1) successive period of five (5) years (the “Renewal Term”), such Renewal Term to commence at the expiration of the extended Lease Term. Tenant shall exercise each option to renew by delivering written notice to Landlord at least nine (9) months prior to the expiration of the extended Lease Term. Any such renewal of this Lease shall be upon the same terms and conditions of the Lease, except the Minimum Annual Rent during the Renewal Term shall be the Fair Market Rent as of the commencement of the Renewal Term for the Leased Premises. Failure by Tenant to provide written notice to Landlord of its intent to renew by the period stated above shall nullify Tenant’s renewal rights. Within thirty (30) days after receiving notice from Tenant of its intention to renew, Landlord will provide Tenant with the Fair Market Rent for the Renewal Term and Tenant shall then have thirty (30) days from receipt of Landlord’s determination of Fair Market Rent to notify Landlord, in writing, that either (a) Tenant accepts Landlord’s determination of Fair Market Rent, in which case Tenant shall be obligated to renew the Lease at the Fair Market Rent rate determined by Landlord, (b) Tenant does not accept Landlord’s determination of the Fair Market Rent and withdraws the exercise of its renewal option, in which case Tenant’s renewal rights and obligations hereunder shall be forever terminated, or (c) Tenant does not accept Landlord’s determination of the Fair Market Rent, but that Tenant still desires to exercise its renewal option, in which case, Landlord and Tenant shall attempt to resolve their differences within thirty (30) days after Landlord’s receipt of Tenant’s notice. If the parties are unable to agree on the Fair Market Rent within the thirty (30) day period, then, within ten (10) days after the expiration of that period, each party, at its cost and by giving notice to the other party, shall appoint a qualified real estate appraiser or broker with at least ten years full time commercial appraisal experience in the Cincinnati, Ohio area to appraise and set the Fair Market Rent for the Leased Premises. The two appraisers or brokers appointed by the parties as stated in this paragraph shall meet promptly and attempt to establish the Fair Market Rent for the Leased Premises. If they are unable to agree within thirty (30) days after the second appraiser or broker has been appointed, they shall attempt to select a third appraiser or broker meeting the qualifications stated in this paragraph within ten (10) days after the last day the two appraiser or brokers are given to set the Fair Market Rent. Each of the parties shall bear one-half (1/2) of the cost of appointing the third appraiser or broker and of paying the third appraiser or broker’s fee. The third appraiser or broker, however selected, shall be a person who has not previously acted in any capacity for either party. Within thirty (30) days

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after the selection of the third appraiser or broker, a majority of the appraisers or brokers shall set the Fair Market Rent for the Leased Premises. If a majority of the appraisers or brokers are unable to set the Fair Market Rent within the stipulated period of time, the three appraisals shall be added together and their total divided by three; the resulting quotient shall be the Fair Market Rent for the Leased Premises.

For purposes of determining Fair Market Rent, the parties agree that “Fair Market Rent” shall be reasonably determined by Landlord, or the brokers or appraisers, if applicable, in accordance with this Section, based on comparable renewing tenants, including leasing concessions, then being offered for comparable office buildings, both in size and in quality, in the submarket for the Building. The Leased Premises will be provided in its then-existing condition (on an “as-is” basis) at the time the Renewal Term commences and Tenant shall not be entitled to any construction, build out or other allowances with respect to the Leased Premises during the Renewal Term except as may be included as part of the determination of Fair Market Rent. All other terms, covenants, and provisions of the Lease shall continue in full force and effect and be applicable to the Renewal Term.

7. Addition of Section  3.05. Landlord’s Options for Payment of Rent . As to the entire Leased Premises for the Lease Term from and after the date hereof, the following Section  3.05 is hereby added to the Lease:

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8. Amendment of Section  6.01. Services to be Provided . As to the entire Leased Premises for the Lease Term from and after the date hereof, Section  6.01 of the Lease is hereby amended by deleting subsections (a), (d), and (e), and substituting the following in lieu thereof:

9. Intentionally deleted .

10. Amendment of Section  7.03. Alterations . As to the entire Leased Premises for the Lease Term from and after the date hereof, Section  7.03 of the Lease is hereby amended by deleting the entirety of Section  7.03 and substituting the following in lieu thereof:

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11. Amendment of Section  8.05. Landlord’s Insurance . As to the entire Leased Premises for the Lease Term from and after the date hereof, Section  8.05(a) of the Lease is hereby amended by deleting the entirety of Section  8.05(a) and substituting the following in lieu thereof:

12. Reaffirmation of Section  16.16. Patriot Act . Landlord and Tenant hereby reaffirm Section  16.16 of the Lease.

13. Waiver of Option to Terminate . The parties hereto acknowledge and agree that the option to terminate as set forth in Section  16.17 of the Lease is hereby waived by Tenant and is null and void and of no force and effect.

14. Waiver of Right of First Refusal . The Right of First Refusal set forth in Paragraph 7 of the First Amendment is hereby waived by the Tenant and is hereby null and void and of no force and effect.

15. Exhibits .

(a) The Contractor’s and Vendors’ “Rules of Conduct” attached as Exhibit B-2 to the Lease are hereby deleted and replaced with the Contractor Rules attached as Exhibit B-2 to this Fourth Amendment.

(b) The Building Rules and Regulations attached as Exhibit E to the Lease are hereby deleted and replaced with the Building Rules attached as Exhibit E to this Fourth Amendment.

16. Broker . The parties represent and warrant that, the only real estate brokers involved in the negotiation and execution of this Lease are the Brokers and that no other party is entitled, as a result of the actions of the respective party, to a commission or other fee resulting from the execution of this Lease. Each party shall indemnify the other from any and all liability for the breach of this representation and warranty on its part and shall pay any compensation to any other broker or person who may be entitled thereto. Landlord shall pay any commissions due Brokers based on this Lease pursuant to separate agreements between Landlord and Brokers.

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17. Representations and Warranties .

(a) Tenant hereby represents and warrants that (i) Tenant is duly organized, validly existing and in good standing (if applicable) in accordance with the laws of the State under which it was organized; (ii) Tenant is authorized to do business in the State where the Building is located; and (iii) the individual(s) executing and delivering this Fourth Amendment on behalf of Tenant has been properly authorized to do so, and such execution and delivery shall bind Tenant to its terms.

(b) Landlord hereby represents and warrants that (i) Landlord is duly organized, validly existing and in good standing (if applicable) in accordance with the laws of the State under which it was organized; (ii) Landlord is authorized to do business in the State where the Building is located; and (iii) the individual(s) executing and delivering this Fourth Amendment on behalf of Landlord has been properly authorized to do so, and such execution and delivery shall bind Landlord to its terms.

18. Examination of Fourth Amendment . Submission of this instrument for examination or signature to Tenant does not constitute a reservation or option, and it is not effective until execution by and delivery to both Landlord and Tenant.

19. Definitions . Except as otherwise provided herein, the capitalized terms used in this Fourth Amendment shall have the definitions set forth in the Lease.

20. Incorporation . This Fourth Amendment shall be incorporated into and made a part of the Lease, and all provisions of the Lease not expressly modified or amended hereby shall remain in full force and effect.

[SIGNATURES CONTAINED ON THE FOLLOWING PAGES]

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IN WITNESS WHEREOF, the parties have caused this Fourth Amendment to be executed on the day and year first written above.

Before me, a Notary Public in and for said County and State, personally appeared David Harrison, by me known and by me known to be the President, VanTrust Real Estate, LLC, a Delaware limited liability company, as Agent of BLUE ASH LANDINGS ACQUISITION, LLC, an Ohio limited liability company, who acknowledged the execution of the foregoing “Fourth Amendment to Amended and Restated Office Lease” on behalf of said limited liability company.

WITNESS my hand and Notarial Seal this 29 day of March, 2018.

				/s/ Cynthia Aitken Notary Public   /s/ Cynthia Aitken Printed Signature

My commission Expires: 4-26-2019

Before me, a Notary Public in and for said County and State, personally appeared Joseph Gardner, by me known and by me known to be the President of AERPIO PHARMACEUTICALS, INC., a Delaware corporation, who acknowledged the execution of the foregoing “Fourth Amendment to Office Lease” on behalf of said limited liability company.

WITNESS my hand and Notarial Seal this 23 ^rd day of March, 2018.

/s/ Jennifer Alicia Tarvin

Notary Public

Printed Signature

My commission Expires: My Commission Expires August 2, 2020

EXHIBIT A

LANDLORD IMPROVEMENTS

[TO BE ATTACHED]

Exhibit A

Page 1 of 1

November 16, 2017

Re: Aerpio, 9987 Carver Rd. Suite 420

The Scope of Work below includes the complete installation of all required items defined below.

Scope of Work Inclusions:

General Conditions:

Cabinetry:

Flooring:

Paint and Coatings:

a2i Creative Building Solutions | 425 Walnut St. Ste 1250 | Cincinnati, OH 45202 | P: 513.252.2209 F: 513.297.2544

www.a2ibuild.com

Qualifications:

Payment Terms:

This proposal was based on a site visit with all responsible trades. All conditions are approximate and subject to field and drawing verification. Any changes resulting from new construction documents may result in additional construction costs or deductions dependent on scope modifications.

We appreciate the opportunity to provide you with this proposal and trust the contents contain the information you require to select a2i as your Design | Build partner.

Thank you,

Betsy Moore

Project Manager

EXHIBIT B-2

CONTRACTOR RULES

Contractors, subcontractors, suppliers, materialmen (hereinafter, each a “Contractor”), shall be advised of the following rules and regulations (the “Contractor Rules”) concerning their proper conduct within the building commonly known as Landings II, located at 9987 Carver Road, Blue Ash, Ohio 45242 (the “Building”), and that certain Leased Premises (as defined in the Lease, as amended by the Fourth Amendment). All referenced material, labor, services, taxes, after hour’s costs, shipping, permits, fees or construction and/or other reference processes performed by Contractor, shall be hereinafter referred to as the “Work.” Any defined terms not otherwise defined herein shall have the same meaning as set forth in the Lease (as defined above).

It is the Contractor’s responsibility to ensure its personnel, subcontractors, suppliers, and materialmen read and understand these Contractor Rules. Ignorance of these Contactor Rules is not a waiver of liability or responsibility. Failure to comply with these Contractor Rules may result in Contractor being asked to leave the job site. Contractor is ultimately responsible for the conduct of its personnel, subcontractors, suppliers, and materialmen. The signature on the last page of these Contractor Rules shall act as the written approval by the Contractor of these Contractor Rules.

1. Prior to starting any Work in the Building, Contractor, at its sole expense, shall procure and maintain during the term of its contract to perform the Work, insurance covering Contractor, its subcontractors and anyone directly or indirectly employed by any of them, issued by an insurance company which has an A.M. Best rating of A-VII or better and is authorized to transact business in the state which the Leased Premises is located. All policies are to protect the Landlord against liabilities arising out of the operations of Contractor and its subcontractors in the performance of the Work, including at least and in amount not less than the following and such other types and amounts of insurance as Landlord deems necessary:

a. Commercial General Liability Insurance. Commercial general liability insurance to protect against claims for bodily injury and property damage arising out of premises operations, products, and completed operations, and advertising and personal injury liability, written on an occurrence basis using ISO Form CG0001 (or its equivalent) with no amendments to the definition of an insured contract, in limits of not less than $1,000,000 inclusive, per occurrence, and $2,000,000 annual aggregate per project with a $2,000,000 Products/Completed Operations Aggregate, or such higher limits as Landlord may require. Completed Operations to remain in force for maintained for the duration of the applicable statute of repose following project completion. To the extent permitted by applicable law, such policy(ies) shall include a waiver of any right of subrogation of the insurers thereunder against Landlord, VanTrust Real Estate, LLC (“VTRE”), Property Manager, and all mortgagees of Landlord;

b. Commercial Automobile Liability Insurance. Commercial automobile liability insurance to include contractual liability insurance for the indemnities set forth in this Contract covering all owned, non-owned and hired automobiles, in limits of not less than $1,000,000 combined single limit (each accident), or such higher limits as Landlord may require. To the extent permitted by applicable law, such policy(ies) shall include a waiver of any right of subrogation of the insurers thereunder against Landlord, VTRE, Property Manager, and all mortgagees of Landlord;

Exhibit B-2

Page 1 of 8

c. Employer’s Liability Insurance and Workers Compensation. Employer’s Liability insurance, with minimum limits of not less than $1,000,000 bodily injury each accident, $1,000,000 bodily injury by disease policy limit and $1,000,000 bodily injury by disease each employee, and Worker’s Compensation, in form and amount as required by applicable state law. To the extent permitted by applicable law, such policy shall include a waiver of any right of subrogation of the insurers thereunder against the Landlord, VTRE, Property Manager, and all mortgagees of Landlord;

d. Umbrella Liability Insurance. Umbrella liability insurance over the primary general liability, automobile liability and employer’s liability insurance policies in limits of not less than $5,000,000 inclusive per occurrence, and $5,000,000 annual aggregate, per project, or such higher limits as Landlord may require. To the extent permitted by applicable law, such policy(ies) shall include a waiver of any right of subrogation of the insurers thereunder against Landlord, VTRE, Property Manager, and all mortgagees of Landlord; and

e. Builder’s Risk Insurance. Builder’s Risk insurance on a “Special Form” basis (including collapse) using a completed value (non-reporting) form for full replacement cost covering all work which Contractor is performing and all materials and equipment used or installed in or about the project, off site and in transit. This insurance shall include: (i) interests of Landlord, VTRE, Property Manager, all tenants, all mortgagees of Landlord, Contractor, subcontractors and sub-subcontractors; and (ii) a mutual release and waiver of subrogation for all parties. At Landlord’s option, Landlord may procure the insurance policy described in this subsection (e) (which may include loss of rents coverage), and Tenant shall reimburse Landlord, at Landlord’s option as either Additional Rent or a deduction from any applicable improvement allowance, all costs and expenses incurred by Landlord in connection therewith.

f. Certificates of insurance must be provided to Landlord prior to the start of the Work on the project site. Landlord, VTRE, Property Manager, all mortgagees, (and others who may be required, as evidenced by inclusion in an Acord Certificate as additional insureds), will be named as primary non-contributing additional insureds on the insurance coverages described in subsections (a) and (d) above, including completed operations with respect to all matters arising out of the performance of services under this Contract. It is Contractor’s sole responsibility to procure and maintain insurance covering its personal property located at the project site. All policies required above shall contain no exclusions for work expressly within the Contractor’s scope of work. It is Landlord’s sole responsibility to procure and maintain property insurance covering Landlord’s real property where the project is located (other than the Work) and Landlord’s personal property and the personal property of others located at the project site that are under Landlord’s care, custody or control.

Exhibit B-2

Page 2 of 8

2. If required pursuant to the Lease, Contractors working in or about the Building must have prior written approval from the Landlord before any type of Work may commence. A list of subcontractors must be provided by the Contractor to the Landlord and Property Manager along with suitable scheduling and delivery / stocking information before construction begins. Any persons not on the approved contractor list will be denied access to the Building–no exceptions. This list will include phone numbers and contacts for Contractor and its subcontractors, including home and emergency telephone numbers.

3. An initial walk through of the job site among Contractor’s superintendent, representatives of Contractor’s key subcontractors, the Property Manager, the Property Manager’s engineer, and any other Landlord representatives will be conducted prior to construction. The foregoing shall review these Contractor Rules, as well as check for existing conditions of the Leased Premises.

4. Contractors and all its subcontractors must be licensed in the state in which the Work is performed, and have work experience in commercial properties similar to the Building.

5. Where applicable, permits must be obtained, by Contractor, from the applicable municipal building department or other governing agency prior to the commencement of Work. Permits must be posted at the job site in accordance with local governmental requirements. All applicable construction Work will require a permit. Approval of drawings, details, schedules, etc., by Landlord or Property Manager shall not relieve the Contractor from the responsibility for compliance with local, county, state or federal laws, rules, ordinances, or rules and regulations of commissions, boards, or other authorities having jurisdiction.

6. Contractor shall keep the Leased Premises and improvements free and clear of all liens arising out of or claimed by reason of any Work performed, materials furnished or obligations incurred. Contractor is responsible for the payment of all bills for labor and materials furnished by or to it and its subcontractors performing Work at the Building.

7. No one shall be allowed to endanger the Building or its occupants in any manner whatsoever. If such a situation occurs, the Contractor shall immediately take steps to correct and eliminate the hazardous condition. In the event that the Contractor to eliminate the hazardous condition in a satisfactory manner, Landlord and Property Manager reserve the right to immediately take steps to remedy the hazardous condition at the Contractor’s sole expense.

8. Contractor is not permitted to post any sign on the job site advertising the name of the Contractor or its subcontractors.

9. It is imperative that good business/professional conduct be maintained by all Contractor’s personnel while they are at the Park and that they are properly dressed for the environment they are working in and the Work being performed. Contractor shall not employ any unfit person or anyone not skilled in the task assigned to Contractor. Respect must be shown to the Building tenants at all times. Rude and obscene behavior (harassment, sexual or otherwise), including foul and abusive language, will not be tolerated. Offenders will be asked to remove themselves from the Park and shall not be permitted to return.

Exhibit B-2

Page 3 of 8

10. All Contractors’ personnel will enter and exit through the South Building entrance (which will be the designated construction entrance), and will only use the designated elevator or designated stairwell except in the event of an emergency evacuation. Use of Building main floor, lobbies, or elevator lobbies is prohibited for storing material even on a temporary basis. Specific Building moving and freight policies are established and must be reviewed with Landlord and/or Property Manager. Where applicable such freight policies may include fines for breaking such policies.

11. Landlord and/or Property Manager, prior to the commencement of the project, must approve hours in which the Work will commence and end each day. No variation to the agreed upon hours will be permitted unless authorization is obtained from Landlord and/or Property Manager. These Contractor Rules as stated herein will further limit hours. Landlord and/or Property Manager must be notified of “after hours” Work in advance. “After hours” work is defined to be before 7 am and after 6 pm or as governed by the City where the project resides and their guidelines. All Contractors working over the weekend and after the normal hours shall provide Landlord and Property Manager a list of workers prior to the worker being on site or they will be denied access. The list should also include an estimated time the Contractors will be working, the location of the work to be done and a 24-hour emergency contact for the supervisor of the Work.

12. Contractor shall designate a superintendent to oversee all workmen at all times. Such superintendent may be given access cards and keys, these cards/keys will grant access to the Building for all workmen associated with the project. The superintendent issued the cards/keys not permitted to give such cards/keys to any workmen for access to the Building. In no event shall any workmen be unsupervised at any time.

13. All deliveries are to be accepted, moved and delivered to the contracted suite before 7 am and after 6 pm unless prior Landlord approval has been granted in writing; stocking will not be allowed during business hours once any tenant occupancy has taken place within the building. When accepting deliveries, masonite must be laid to protect walls and floor finishes and elevator pads must be installed prior to delivery. It is the Contractor’s responsibility to keep public areas clean at all times.

14. No windows shall be removed without prior approved permission provided by Property Manager or Landlord.

15. All construction waste and debris shall be removed between the hours of 6 pm to 7 am once any tenant occupancy within the Building has taken place. No construction waste or debris may be placed in the building dumpster /compactor. The Contractor will provide for removal of waste and debris from the building at his own expense. If a dumpster is required (space allowing), the location shall be authorized by the Landlord and Property Manager, must be in a safe location, and will meet the Building’s standard relating to aesthetics. It will be the responsibility of the Contractor to keep the area around the container neat and orderly daily. It will also be the Contractor’s responsibility to place plywood under the dumpster and to take other protective measures to protect the asphalt and concrete where the dumpster is to be place. It will be important to assure that a trail of debris is not left between the Work areas and refuse container.

Exhibit B-2

Page 4 of 8

16. Construction personnel shall at all times maintain the highest level of project cleanliness. All construction debris shall be removed through the service elevator or stairs on a daily basis and shall never be allowed to produce a fire hazard. In the event that the Contractor fails or refuses to keep the Leased Premises free of accumulated waste, Landlord and/or Property Manager reserve the right, but not the obligation, to enter the Leased Premises and remove the debris, on behalf of the Contractor, at the Contractor’s expense. In addition, all public areas, i.e., corridors, restrooms, janitor’s closets, etc. shall be maintained and kept free of construction debris, dust, etc.

17. No one is permitted to use the janitorial closets without permission. Contractor shall be responsible for stocking and re-stocking of restroom supplies as well as clean-up of the subject restrooms being utilized, provided such authorization of use has been granted by Landlord, throughout the duration of construction. Upon completion of each tenant improvement, the Contractor will be responsible for restoring the facility to its original state. All carpeted corridors will be properly protected by masonite or carpet mask (Polytech brand only) flush with the base, from the point of entry to the job site to the restroom. Contractor will provide walk-off mats to be placed at all locations where Contractors enter public areas of the building. These walk-off mats will be maintained and cleaned daily or more frequently if required, so that construction material is not transferred unto any other areas of the building. Any flammable or hazardous materials (i.e., paint) may only be stored on premises with permission of Landlord and Property Manager who shall designate an area for such storage.

18. Pre-filters shall be installed over all return air openings on floors under construction. If Building filters or equipment requires replacement or cleaning due to construction dust, the Contractor will be charged.

19. Contractor should cover air transfers when working next to tenanted space to control the transmission of dust and dirt. Covering must be removed at the completion of daily construction. All tenant entrance and exit doors must be kept closed to restrict the movement of dust or dirt. Temporary openings with polyurethane must be closed off. Due to local fire codes, no openings may be made on a tenanted floor to the corridor unless the door to be made on the tenanted floor to the corridor remains closed unless materials are being delivered. All HVAC filters in fan rooms shall also be delivered in operable condition at time of completion (thus a temporary filter should be added to the existing filter).

20. Electrical Panels must be closed up at the end of each working day. Interior panels can be covered or barricaded. Doors to all electrical rooms must remain locked when not occupied or protected by barrier. No storage is allowed in the electrical room. DO NOT TAPE OVER LOCKS TO LEAVE DOOR OPEN OR USE ANY MECHANICAL DEVICE TO PROP OPEN. REPEATED VIOLATIONS WILL BE FINED $500 PER EVENT.

Exhibit B-2

Page 5 of 8

21. Any and all safety equipment, such as traffic control, flagmen, barricades, rigging, fire extinguishers, first aid supplies, etc., as may be necessary or required by any agency having jurisdiction, shall be the sole responsibility of, and at the expense of, Contractor. It is the responsibility of the Contractor to protect all individuals surrounding the Work area. All liability shall be the responsibility of the Contractor. Contractor (and its subcontractors) shall inaugurate and maintain an accident prevention program and an employee safety-training program. Proof of compliance for the state and city where the project resides of your safety plan shall be maintained and followed. All employees on the job, regardless of whose direct payroll they are on, shall be required to respond to safety instructions from the Contractor’s supervision. Persons who do not respond shall be removed from the job. Contractor, its subcontractors, labor, agents and invitees shall be responsible for complying with all OSHA rules and regulations, including, without limitation, having all safety, first aid and Material Safety Data Sheet (MSDS) documentation on the jobsite at the Building.

22. All Contractors are to take precautions to prevent the accidental tripping of the fire alarm system. The smoke detectors must be covered during working hours and uncovered at the end of the working day.

False alarms shall be fined at:

First offense: $200

Second offense: $500

Third offense: $1000 and, at the Landlord’s discretion, may terminate Contractor.

23. No gasoline operated devices, i.e., concrete saws, coring machines, welding machines, etc., shall be permitted within the Building. All work requiring such devices shall be by means of electrically operated substitutes.

24. All approved gas and oxygen canisters shall be properly chained and supported to eliminate all potential hazards. At the completion of use, said containers shall be removed from the Building.

25. Please contact the Property Manager to schedule work on the following building systems 24- hours in advance (Any disruption of services will be scheduled at the Property Manager’s discretion):

a. Domestic water;

b. Fire alarm or speaker;

c. Electrical tie-ins to base building or the addition of equipment to any area other than the tenant suite except sub panels located within the Leased Premises;

d. Sprinkler system;

e. Any work that will take place outside the demised tenant space;

f. Work in occupied tenant spaces. This includes any core drilling, plumbing, and electrical, etc., where you will enter an adjacent tenant space;

g. Roof access. Any corrective work required in conjunction with or as a result of this Contractor’s scope of work shall be performed by a firm authorized as such by roofing manufacturer (Landlord and/or Property Manager will coordinate with Contractor in determining) for purposes of ensuring that the roofing warranty is not jeopardized in any way.

Exhibit B-2

Page 6 of 8

Note: If a utility or building alarm is turned off for Contractor’s work, Contractor must notify the Property Manager upon completion so the system can be turned back on as soon as possible.

26. Construction personnel are not permitted to block open stairway doors. These doors provide the fire protection required by code. A repeated violation of this provision shall be subject to a $500 fine. Doors to janitorial spaces shall be kept closed at all times.

27. No graffiti or vandalism will be tolerated. Any individual caught in the act shall be immediately removed from the Leased Premises and will not be allowed to return. In addition, all repairs will be at the Contractor’s expense.

28. No tobacco smoking or chewing will be permitted in the Building or on the roof. No radios or other sound producing equipment will be permitted in the Building or on the roof. No eating or drinking will be allowed in the Common Areas. Building management will either provide a designated smoking area or designate the property to be non-smoking.

29. Since Work may occur while other businesses in the Building are operating, noise is a major consideration. Therefore, excessive noise, which may disturb tenants, will force us to halt Work temporarily. No hammer drilling, core drilling or any tenant disturbances will be allowed between the hours of 7 am and 6 pm, Monday through Friday. It is the responsibility of the Contractor to instruct all construction personnel that noise will be minimized at all times. Landlord and Property Manager shall determine acceptable noise level.

30. Wet paint sign must be posted in all public areas when appropriate.

31. The odors, which arise when various construction procedures are done, can cause discomfort to the tenants of the Building. Examples of these odor concerns are carpet adhesive, wallpaper sizing, wood stains and finishes and painting. These activities which sometimes produce odor problems for tenants in the Building will be done during evening non-business hours, as approved by Landlord and/or Property Manager. Also, Landlord and/or Property Manager should be alerted to arrange for added ventilation. Cost associated with additional ventilation shall be at Contractor’s sole expense. In addition, all TI Contractors will cooperate with shell building contractor’s air quality reading measurements as is required by LEED, when applicable. This may include temporary shutdown of activity that jeopardizes air quality readings before and during actual testing of same.

32. Contractor shall provide temporary electrical devices within the Leased Premises for its subcontractor’s use. Contractor will not be permitted to run extension cords through public space on occupied floors or through occupied tenant spaces.

Exhibit B-2

Page 7 of 8

33. Contractor shall use reasonable measures to minimize energy consumption in the construction area when possible. The Building shall pay for normal electrical consumption during the construction process. All lights and equipment must be extinguished at the end of the Contractor’s business day. In the event that the Contractor continues to leave lights and equipment on during off-hours, Landlord reserves the right to receive just compensation for excessive electrical consumption.

34. Contractor/Sub-contractor may park in designated spaces only. This on-site parking is limited to that which is available on-site. Contractor shall be prepared to make additional arrangements should supplemental parking be required for any and all workforces working under their contracted scope. Any vehicles found in unauthorized spaces will be subject to posted parking rates, tickets, towing or other steps as may be needed to avoid conflicts with adjacent tenant and neighbor parking. Specific instructions should be obtained from Property Manager.

35. No work is to be performed, nor materials stored in any area other than the suite under construction without prior authorization. No staging of trucks or materials will be allowed in areas that may affect traffic flow.

36. Rubber wheels are required on all vehicles transporting materials in the Building.

37. All equipment and material will be designed and attached for seismic loading in accordance with governmental agencies having jurisdiction over the Work.

38. Commencement of any work shall constitute acceptance or contractor will take full responsibility for communicating these Contractor Rules to all Contractor’s personnel and subcontractors, and enforcing these Contractor Rules in regards to employees of Contractor and subcontractors.

Exhibit B-2

Page 8 of 8

EXHIBIT E

BUILDING RULES

Notwithstanding anything to the contrary contained herein, in the event of a conflict between the terms and conditions of the Building rules and regulations, now or hereafter promulgated by Landlord, and the terms and conditions of the Lease, the Lease shall control.

1. The sidewalks, entrances, passages, courts, elevators, vestibules, stairways, corridors or halls shall not be obstructed or used for any purpose other than ingress and egress. Landlord shall control the Common Areas.

2. No awnings or other projections shall be attached to the outside walls of the Building. No curtains, blinds, or screens shall be attached to or hung in, or used in connection with, any window or door of the Leased Premises other than Landlord standard window coverings without Landlord’s prior written approval. Neither the interior nor the exterior of any windows shall be coated or otherwise sunscreened without written consent of Landlord.

3. No sign, advertisement, notice or handbill shall be exhibited, distributed, painted or affixed by any tenant on, about or from any part of the Leased Premises, the Building or in the Common Areas including the parking area without the prior written consent of Landlord. In the event of the violation of the foregoing by any tenant, Landlord may remove or stop same without any liability, and may charge the expense incurred in such removal or stopping to tenant. The lobby directory will be provided exclusively for the display of the name and location of tenants only, and Landlord reserves the right to exclude any other names therefrom. Nothing may be placed on the exterior of corridor walls or corridor doors other than Landlord’s standard lettering.

4. The sashes, sash doors, windows, and doors that reflect or admit light and air into halls, passageways or other public places in the Building shall not be covered or obstructed by tenant.

5. The sinks and toilets and other plumbing fixtures shall not be used for any purpose other than those for which they were constructed, and no sweepings, rubbish, rags, or other substances shall be thrown therein. All damages resulting from any misuse of the fixtures shall be borne by the tenant who, or whose subtenants, assignees or any of their servants, employees, agents, visitors or licensees shall have caused the same.

6. No tenant shall mark, paint, drill into, or in any way deface any part of the Leased Premises or the Building (except for nails for the display of artwork). No boring, cutting or stringing of wires or laying of any floor coverings shall be permitted, except with the prior written consent of the Landlord and as the Landlord may direct. Landlord shall direct electricians as to where and how telephone or data cabling are to be introduced. No boring or cutting for wires or stringing of wires will be allowed without written consent of Landlord.

7. No bicycles, vehicles, birds or animals of any kind (except seeing eye dogs) shall be brought into or kept in or about the Leased Premises, and no cooking shall be done or permitted by any tenant on the Leased Premises, except microwave cooking, and the preparation of coffee, tea, hot chocolate and similar items for tenants and their employees. No tenant shall cause or permit any unusual or objectionable odors to be produced in or permeate from the Leased Premises.

Exhibit E

Page 1 of 4

8. The Leased Premises shall not be used for manufacturing or for the storage of merchandise except as such storage may be incidental to the Permitted Use of the Leased Premises. No tenant shall occupy or permit any portion of the Leased Premises to be occupied as an office for the manufacture or sale of liquor, narcotics, or tobacco in any form, or as a medical office, or as a barber or photographic or print shop or an employment bureau without the express written consent of Landlord. The Leased Premises shall not be used for lodging or sleeping or for any immoral or illegal purpose.

9. No tenant shall make, or permit to be made any unseemly, excessive or disturbing noises or disturb or interfere with occupants of this or neighboring buildings or premises or those having business with them, where by the use of any musical instrument, radio, phonograph, unusual noise, or in any other way. No tenant shall throw anything out of doors, windows or down the passageways.

10. No tenant, subtenant or assignee nor any of it servants, employees, agents, visitors, or licensees, shall at any time bring or keep upon the Leased Premises any flammable, combustible or explosive fluid, chemical or substance or firearm.

11. No additional locks or bolts of any kind shall be placed upon any of the doors or windows by any tenant, nor shall any changes be made to existing locks or the mechanism thereof.

12. No tenant shall overload the floors of the Leased Premises. All damage to the floor, structure or foundation of the Building due to improper positioning or storage items or materials shall be repaired by Landlord at the sole cost and expense of tenant, who shall reimburse Landlord immediately therefor upon demand. All removals or the carrying in or out of any safes, freight, furniture, of bulky matter of any description must take place during the hours that Landlord shall reasonably determine from time to time. The moving of safes or other fixtures or bulky matter of any kind must be done upon previous notice to Landlord and under Landlord’s supervision, and the persons employed by any tenant for such work must be acceptable to Landlord. Landlord reserves the right to inspect all safes, freight or other bulky articles to be brought into the Building and to exclude from the Building all safes, freight or other bulky articles which violate any of these Rules and Regulations or the Lease of which these Rules and Regulations are a part. The Landlord reserves the right to prescribe the weight and position of all safes, which must be placed upon supports approved by Landlord to distribute the weight.

13. Landlord shall have the right to prohibit any advertising by any tenant that, in Landlord’s reasonable opinion tends to impair the reputation of the Building or its desirability as an office location, and upon written notice from Landlord, any tenant shall refrain from or discontinue such advertising.

Exhibit E

Page 2 of 4

14. The business hours for the Building shall be 7:00 a.m. to 6:00 p.m. Monday through Friday and 8:00 a.m. to 1:00 p.m. on Saturday, excluding legal holidays. Landlord reserves the right to require all persons entering the Building between the hours of 6:00 p.m. to 7:00 a.m. and at all hours on Saturday, Sunday, and legal holidays to register with Landlord’s security personnel. Each tenant shall be responsible for all persons entering the Building at tenant’s invitation, express or implied. Landlord shall in no case be liable for damages for any error with regard to admission to or exclusion from the Building of any person. In case of an invasion, mob riot, public excitement or other circumstances rendering such action advisable in Landlord’s opinion, Landlord reserves the right without any abatement or rent to require all persons to vacate the Building and to prevent access to the Building during the continuance of the same for the safety of the tenants and the protection of the Building and the property in the Building.

15. No tenant shall purchase janitorial or maintenance of other like services, from any person or persons not approved by Landlord. Any persons employed by any tenant to do janitorial work or other work in the Leased Premises shall, while in the Building and outside of the Leased Premises, be subject to and under the control and direction of Landlord (but not as an agent or servant of Landlord), and tenant shall be responsible for all acts of such persons.

16. Canvassing, soliciting and peddling in the building are prohibited, and each tenant shall report and otherwise cooperate to prevent the same.

17. All office equipment of any electrical or mechanical nature shall be placed by tenant in the Leased Premises in setting that will, to the maximum extent possible, absorb or prevent any vibration, noise and annoyance.

18. No future air-conditioning unit or other similar apparatus shall be installed or used by any tenant without the written consent of Landlord.

19. There shall not be used in any space, or in the public halls of the Building, either by any tenant or others, any hand trucks except those equipped with rubber tires and rubber side guards.

20. The scheduling of tenant move-ins shall be before or after normal business hours and on weekends, subject to the reasonable discretion of Landlord.

21. The Building is a smoke-free Building. Smoking is strictly prohibited within the Building. Smoking shall only be allowed in areas designated as a smoking area by Landlord. Tenant and its employees, representatives, contractors or invitees shall not smoke within the Building or throw cigar or cigarette butts or other substances or litter of any kind in or about the Building, except in receptacles for that purpose. Landlord may, at its sole discretion, impose a charge against monthly rent of $50.00 per violation by tenant or any of its employees, representatives, contractors or invitees, of this smoking policy.

22. Tenants will insure that all doors are securely locked, and water faucets, electric lights and electric machinery are turned off before leaving the Building.

Exhibit E

Page 3 of 4

23. Parking spaces associated with the Building are intended for the exclusive use of passenger automobiles. Except for intermittent deliveries, no vehicles other than passenger automobiles may be parked in a parking space without the express written permission of Landlord. Tenant, its employees, customers, invitees and guests shall, when using the parking facilities in and around the Building, observe and obey all signs regarding fire lanes and no-parking and driving speed zones and designated handicapped and visitor spaces, and when parking always park between the designated lines. Landlord reserves the right to tow away, at the expense of the owner, any vehicle which is improperly parked or parked in a no-parking zone or in a designated handicapped area, and any vehicle which is left in any parking lot in violation of the foregoing regulation. All vehicles shall be parked at the sole risk of the owner, and Landlord assumes no responsibility for any damage to or loss of vehicles except to the extent arising out of the negligence or willful misconduct of Landlord, the managing agent or any of their respective partners, directors, officers, agents or employees.

24. Tenant shall be responsible for and cause the proper disposal of medical waste, including hypodermic needles, created by its employees.

25. It is Landlord’s desire to maintain in the Building and Common Areas the highest standard of dignity and good taste consistent with comfort and convenience for tenants. Any action or condition not meeting this high standard should be reported directly to Landlord. The Landlord reserved the right to make such other and further rules and regulations as in its judgment may from time to time be necessary for the safety, care and cleanliness of the Building and Common Areas, and for the preservation of good order therein.

Exhibit E

Page 4 of 4