☒ |
ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934
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☐ |
TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934
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Delaware
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36-4742850
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(State or other jurisdiction of
incorporation or organization)
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(I.R.S. Employer
Identification No.)
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Title of each class
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Trading
Symbol(s)
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Name of each exchange
on which registered
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||
Common Stock, $0.0001 Par Value Per Share
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ITCI
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The Nasdaq Global Select Market
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Large accelerated filer
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☒
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Accelerated filer
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☐
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Non-accelerated
filer
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☐
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Smaller reporting company
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☐
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Emerging growth company
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☐
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4
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Item 1.
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4
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Item 1A.
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25
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Item 1B.
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53
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Item 2.
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53
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Item 3.
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53
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Item 4.
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53
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54
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Item 5.
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54
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Item 6.
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55
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Item 7.
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56
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Item 7A.
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68
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Item 8.
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69
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Item 9.
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69
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Item 9A.
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69
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Item 9B.
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71
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72
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Item 10.
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72
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Item 11.
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72
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Item 12.
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72
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Item 13.
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72
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Item 14.
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72
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73
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Item 15
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73
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Item 16.
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78
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79
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Item 1.
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BUSINESS
|
• |
we seek to have the capability to develop
first-in-class
medications with novel mechanisms that have the potential to treat CNS diseases and other diseases for which there are no previously marketed drugs; and
|
• | we seek to develop drugs that either can differentiate themselves in competitive markets by addressing aspects of CNS diseases and other diseases which are not adequately treated by currently marketed drugs or can be effective with fewer side effects. |
• | initiate the commercialization of CAPLYTA, which was approved in December 2019 by the FDA for the treatment of schizophrenia in adults, in the United States; |
• | complete the development of lumateperone for additional neuropsychiatric indications, such as bipolar disorder, behavioral disturbances in dementia, including AD, residual symptoms in schizophrenia and major depressive disorder, or MDD; |
• | expand the commercial potential of lumateperone by investigating its usefulness in additional neurological areas, such as autism spectrum disorder, and in additional neuropsychiatric indications, such as sleep disorders associated with neuropsychiatric and neurological disorders; |
• |
continue to develop PDE inhibitor compounds, such as
ITI-214,
for the treatment of CNS and other disorders; and
|
• |
advance earlier stage product candidates in our pipeline, such as
ITI-333,
for substance use disorders, pain and psychiatric comorbidities including depression and anxiety.
|
Summary Description of Patent
or Patent Application
|
United States or Foreign
Jurisdiction
|
Expiration Date
|
||
Base
ITI-007
Patent (lumateperone tosylate)
|
Granted:
|
June 15, 2020
(does not include expected
6-month
extension in US for pediatric studies)
|
||
ITI-007
Product Patent (approved drug product—lumateperone tosylate—in any pharmaceutical form)
|
Granted:
Pending in AU, EP (allowed), IN JP, KR, and MX
|
March 12, 2028 (US: does not include expected
6-month
extension in US for pediatric studies)
|
||
ITI-007
Crystal Form Patent (approved drug product—lumateperone tosylate—in solid crystalline form)
|
Granted:
|
December 1, 2029 (US; does not include expected
6-month
extension for pediatric studies; additional patent term extension possible through 2033**);
March 12, 2029
(ex-US)
|
||
|
Pending in IL, IN
|
|
Summary Description of Patent
or Patent Application
|
United States or Foreign
Jurisdiction
|
Expiration Date
|
||
ITI-007
Dosage and Method of Treatment Patents (including schizophrenia, bipolar depression, sleep disorder indications)
|
Granted:
Pending: US (continuation), CA, (divisional), EP, IN, KR, MX (divisional)
|
December 28, 2029 (US; does not include expected
6-month
extension for pediatric studies; additional patent term extension possible through 2033**);
May 27, 2029
(ex-US)
|
||
ITI-007
Residual Symptoms Patent (treatment of negative/residual symptoms of schizophrenia)
|
Granted:
Pending: US (continuation), AU (divisional), JP (divisional), EP, IN, KR, MX, CA, BR IL, CN
|
December 3, 2034 (US and
ex-US;
does not include expected US
6-month
extension for pediatric studies;)
|
||
Patents for Additional Dosage Forms
|
Pending: US provisional, US national and/or PCT
|
2037-2039
|
||
Patents for Additional Indications (including post-traumatic stress disorder, impulse control disorder, symptoms associated with dementia, acute depression, and acute anxiety)
|
Granted
|
2033-2034
|
* | Orange-Book listed U.S. patents |
** | We have filed patent term extension applications on three U.S. patents. The U.S. Patent and Trademark Office, or USPTO, has not completed its review of these applications. In the United States, we are permitted to extend the term of one U.S. patent for lumateperone or the use thereof. Accordingly, on completion of the USPTO’s review of our patent term extension applications, we must select one of the three patents to which any patent term extension granted will attach. Patent terms may be subject to change not only due to potential patent term extensions but also to any terminal disclaimer that reduces patent term, as well as other factors. Because the U.S. patent laws and related judicial interpretations change, modifications or new interpretations of the laws may impact our patent terms. |
• | identifying and validating targets; |
• | screening compounds against targets; |
• | preclinical studies and clinical trials of potential pharmaceutical products; and |
• | obtaining FDA and other regulatory clearances. |
• | capital resources; |
• | research and development resources; |
• | manufacturing capabilities; and |
• | sales and marketing. |
• | completion of extensive preclinical laboratory tests, animal studies, and formulation studies in accordance with the FDA’s Good Laboratory Practice, or GLP, regulations; |
• | submission to the FDA of an IND for human clinical testing, which must become effective before human clinical trials may begin; |
• | performance of adequate and well-controlled human clinical trials to establish the safety and efficacy of the drug for each proposed indication; |
• | submission to the FDA of an NDA after completion of all clinical trials; |
• |
satisfactory completion of an FDA
pre-approval
inspection of the manufacturing facility or facilities at which the API and finished drug product are produced and tested to assess compliance with current Good Manufacturing Practices, or cGMPs;
|
• | satisfactory completion of FDA inspections of clinical trial sites to assure that data supporting the safety and effectiveness of product candidates has been generated in compliance with Good Clinical Practices; and |
• | FDA review and approval of the NDA prior to any commercial marketing or sale of the drug in the United States. |
• | Phase 1 usually involves the initial introduction of the investigational drug into a limited population, typically healthy humans, to evaluate its short-term safety, dosage tolerance, metabolism, pharmacokinetics and pharmacologic actions, and, if possible, to gain an early indication of its effectiveness. |
• | Phase 2 usually involves trials in a limited patient population to (i) evaluate dosage tolerance and appropriate dosage; (ii) identify possible adverse effects and safety risks; and (iii) evaluate preliminarily the efficacy of the drug for specific targeted indications. Multiple Phase 2 clinical trials may be conducted by the sponsor to obtain information prior to beginning larger and more expensive Phase 3 clinical trials. |
• | Phase 3 trials, commonly referred to as pivotal studies, are undertaken in an expanded patient population at multiple, geographically dispersed clinical trial centers to further evaluate clinical efficacy and test further for safety by using the drug in its final form. |
• | The federal Anti-Kickback Law, which prohibits, among other things, knowingly or willingly offering, paying, soliciting or receiving remuneration, directly or indirectly, in cash or in kind, to induce or reward the purchasing, leasing, ordering or arranging for or recommending the purchase, lease or order of any health care items or service for which payment may be made, in whole or in part, by federal health care programs such as Medicare and Medicaid; |
• | The federal civil False Claims Act, which prohibits, among other things, individuals or entities from knowingly presenting, or causing to be presented, a false or fraudulent claim for payment of |
government funds or knowingly making, using or causing to be made or used, a false record or statement material to an obligation to pay money to the government or knowingly concealing or knowingly and improperly avoiding, decreasing or concealing an obligation to pay money to the federal government; |
• | The federal Health Insurance Portability and Accountability Act of 1996, or HIPAA, which imposes criminal liability for knowingly and willfully executing a scheme to defraud any healthcare benefit program, knowingly and willfully embezzling or stealing from a health care benefit program, willfully obstructing a criminal investigation of a health care offense, or knowingly and willfully making false statements relating to healthcare matters; |
• | The federal Physician Payment Sunshine Act, being implemented as the Open Payments Program, requires certain pharmaceutical manufacturers to engage in extensive tracking of payments and other transfers of value to physicians and teaching hospitals, and to submit such data to the Centers for Medicare and Medicaid Studies (“CMS”), which will then make all of this data publicly available on the CMS website; and |
• | Analogous state laws and regulations, including state anti-kickback and false claims laws, which may apply to items or services reimbursed under Medicaid and other state programs or, in several states, apply regardless of the payer, as well as other state laws that require pharmaceutical companies to report expenses related to the marketing and promotion of pharmaceutical products, prohibit certain gifts or payments to health care providers in the state, and/or require pharmaceutical companies to implement compliance programs or marketing codes of conduct. |
Item 1A.
|
RISK FACTORS
|
• | the efficacy, cost, approved use, and side-effect profile of CAPLYTA regimens relative to competitive treatment regimens for the treatment of schizophrenia; |
• | the timing of the initiation of our commercial launch of CAPLYTA; |
• | the effectiveness of our commercial strategy for the launch and marketing of CAPLYTA, including our pricing strategy and the effectiveness of our efforts to obtain adequate third-party reimbursements; |
• | maintaining and successfully monitoring commercial manufacturing arrangements for CAPLYTA with third-party manufacturers to ensure they meet our standards and those of regulatory authorities, including the FDA, which extensively regulate and monitor pharmaceutical manufacturing facilities; |
• | our ability to meet the demand for commercial supplies of CAPLYTA; |
• | the acceptance of CAPLYTA by patients, the medical community and third-party payors; and |
• | the effect of recent or potential health care legislation in the United States. |
• | the costs of maintaining and developing our sales and marketing capabilities for lumateperone; |
• | the amount of product sales from lumateperone; |
• | the costs of preparing applications for regulatory approvals for lumateperone in additional indications other than in schizophrenia, and potentially in jurisdictions other than the United States, and for other product candidates, as well as the costs required to support review of such applications; |
• | the costs of manufacturing and distributing lumateperone for commercial use in the United States; |
• | our ability to obtain regulatory approval for, and subsequently generate product sales from, lumateperone in additional indications other than in schizophrenia or in jurisdictions other than the United States; |
• | the progress in, and the costs of, our preclinical studies and clinical trials and other research and development programs; |
• | the scope, prioritization and number of our research and development programs; |
• | the ability of any future collaborators and us to reach the milestones, and other events or developments, triggering payments under any future collaboration agreements or to otherwise make payments under such agreements; |
• | our ability to enter into new, and to maintain any existing, collaboration and license agreements; |
• | the extent to which any future collaborators are obligated to reimburse us for clinical trial costs under any future collaboration agreements; |
• | the costs involved in filing, prosecuting, enforcing and defending patent claims and other intellectual property rights; |
• | the costs of maintaining or securing manufacturing and supply arrangements for clinical or commercial production of lumateperone or our other product candidates; |
• | the costs of preparing applications for regulatory approvals for our product candidates; |
• | the costs of preparing for and establishing, or contracting for, sales and marketing capabilities if we obtain regulatory approvals for our product candidates; |
• | the costs involved in expanding the accounting and data management systems to support commercial operations; and |
• | the costs associated with litigation, including the costs incurred in defending against any product liability claims that may be brought against us related to lumateperone or our other product candidates. |
• | withdrawal of approval, addition of warnings or narrowing of the approved indication in the product label; |
• |
requirement of a Risk Evaluation and Mitigation Strategy to mitigate the risk of
off-label
use in populations where the FDA may believe that the potential risks of use may outweigh its benefits;
|
• | voluntary or mandatory recalls; |
• | warning letters; |
• | suspension of any ongoing clinical studies; |
• | refusal by the FDA or other regulatory authorities to approve pending applications or supplements to approved applications filed by us, or suspension or revocation of product approvals; |
• | restrictions on operations, including restrictions on the marketing or manufacturing of the product or the imposition of costly new manufacturing requirements; or |
• | seizure or detention, or refusal to permit the import or export of products. |
• | we may be required to conduct additional clinical trials or implement a Risk Evaluation and Mitigation Strategies program prior to or following approval; |
• | regulatory authorities may not approve our product candidates or, as a condition of approval, may require specific warnings and contraindications; |
• | regulatory authorities may withdraw their approval of the product and require us to take our drug off the market; |
• | we may have limitations on how we promote our drugs; |
• | sales of products may decrease significantly; |
• | we may be subject to litigation or product liability claims; and |
• | our reputation may suffer. |
• | we may not be able to control the amount and timing of resources that our collaborators may devote to the drug candidates; |
• | our collaborators may experience financial difficulties; |
• | we may be required to relinquish important rights, such as marketing and distribution rights; |
• | business combinations or significant changes in a collaborator’s business strategy may also adversely affect a collaborator’s willingness or ability to complete its obligations under any arrangement; |
• | a collaborator could independently move forward with a competing drug candidate developed either independently or in collaboration with others, including our competitors; and |
• | collaborative arrangements are often terminated or allowed to expire, which would delay the development and may increase the cost of developing our drug candidates. |
• | fail to receive the regulatory approvals required to market them as drugs; |
• | be subject to proprietary rights held by others requiring the negotiation of a license agreement prior to marketing; |
• | be difficult or expensive to manufacture on a commercial scale; |
• | have adverse side effects that make their use less desirable; or |
• | fail to compete with product candidates or other treatments commercialized by our competitors. |
• | our ability to provide acceptable evidence of safety and efficacy; |
• | the scope of the approved indication(s) for the product; |
• | the inclusion of any warnings or contraindications in the product label; |
• | pricing and cost effectiveness, which may be subject to regulatory control; |
• | our ability to obtain sufficient third-party insurance coverage or reimbursement; |
• | effectiveness of our or our collaborators’ sales and marketing strategy; |
• | relative convenience and ease of administration; |
• | patient adherence to treatment; |
• | prevalence and severity of any adverse side effects; and |
• | availability of alternative treatments. |
• | imposition of an annual, nondeductible fee on any entity that manufactures or imports certain branded prescription drugs and biologic agents, apportioned among these entities according to their market share in certain government health care programs; |
• | an increase in the statutory minimum rebates a manufacturer must pay under the Medicaid Drug Rebate Program, retroactive to January 1, 2010, to 23% and 13% of the average manufacturer price for most branded and generic drugs, respectively; |
• | expansion of health care fraud and abuse laws, including the False Claims Act and the Anti-Kickback Statute, new government investigative powers, and enhanced penalties for noncompliance; |
• |
a Medicare Part D coverage gap discount program, in which manufacturers agreed to offer 50%
point-of-sale
discounts off negotiated prices of applicable brand drugs to eligible beneficiaries during their coverage gap period, as a condition for the manufacturer’s outpatient drugs to be covered under Medicare Part D;
|
• | extension of manufacturers’ Medicaid rebate liability to covered drugs dispensed to individuals who are enrolled in Medicaid managed care organizations; |
• | expansion of eligibility criteria for Medicaid programs; |
• | expansion of the entities eligible for discounts under the Public Health Service pharmaceutical pricing program; |
• | requirements to report certain financial arrangements with physicians and teaching hospitals, including reporting any “payments or transfers of value” made or distributed to prescribers, teaching hospitals and other health care providers and reporting any ownership and investment interests held by physicians and their immediate family members and applicable group purchasing organizations during the preceding calendar year; |
• | a requirement to annually report drug samples that manufacturers and distributors provide to physicians; and |
• | a Patient-Centered Outcomes Research Institute to oversee, identify priorities in, and conduct comparative clinical effectiveness research, along with funding for such research. |
• | we may not have been the first to make the inventions covered by our pending patent applications or issued patents; |
• | we may not have been the first to file patent applications for our products, product candidates or the technologies we rely upon; |
• | others may independently develop similar or alternative technologies or duplicate any of our technologies; |
• | our disclosures in patent applications may not be sufficient to meet the statutory requirements for patentability; |
• | any or all of our pending patent applications may not result in issued patents; |
• | we may not seek or obtain patent protection in all countries that will eventually provide a significant business opportunity; |
• | any patents issued to us or our collaborators may not provide a basis for commercially viable products, may not provide us with any competitive advantages or may be challenged by third parties; |
• | our proprietary technologies may not be patentable; |
• | others may design around our patent claims to produce competitive products which fall outside of the scope of our patents; |
• | others may identify prior art which could invalidate our patents; and |
• | changes to patent laws may limit the exclusivity rights of patent holders. |
• | identifying and validating targets; |
• | screening compounds against targets; |
• | preclinical studies and clinical trials of potential pharmaceutical products; |
• | obtaining FDA and other regulatory approvals; and |
• | commercializing pharmaceutical products. |
• | decreased demand for our products or product candidates that we may develop; |
• | injury to our reputation; |
• | withdrawal of clinical trial participants; |
• | initiation of investigations by regulators; |
• | costs to defend the related litigation; |
• | a diversion of management’s time and our resources; |
• | substantial monetary awards to trial participants or patients; |
• | product recalls, withdrawals or labeling, marketing or promotional restrictions; |
• | loss of revenue; |
• | exhaustion of any available insurance and our capital resources; |
• | the inability to commercialize our products or product candidates; and |
• | a decline in our stock price. |
• | the success of our commercial launch and commercialization of CAPLYTA in the United States for the treatment of schizophrenia; |
• | timing and announcement of regulatory developments, submissions and approvals or preliminary, interim or final results of clinical trials; |
• | actual or anticipated quarterly variation in our results of operations or the results of our competitors; |
• | announcements of medical innovations or new products or product candidates by our competitors; |
• | issuance of new or changed securities analysts’ reports or recommendations for our stock; |
• | developments or disputes concerning our intellectual property or other proprietary rights; |
• | commencement of, or our involvement in, litigation; |
• | market conditions in the biopharmaceutical industry; |
• | any future sales of our common stock or other securities in connection with raising additional capital or otherwise; |
• | any major change to the composition of our board of directors or management; and |
• | general economic conditions and slow or negative growth of our markets. |
• | the accuracy of our estimates regarding expenses, future revenues, uses of cash, cash equivalents and investment securities, capital requirements and the need for additional financing; |
• | the initiation of the commercial launch of CAPLYTA for the treatment of schizophrenia in adults in the United States; |
• |
the initiation, cost, timing, progress and results of our development activities,
non-clinical
studies and clinical trials;
|
• | the timing of and our ability to obtain and maintain regulatory approval, or submit an application for regulatory approval, of lumateperone and our other existing product candidates, any product candidates that we may develop, and any related restrictions, limitations, and/or warnings in the label of any approved product candidates; |
• | our plans to research, develop and commercialize lumateperone and other current and future product candidates; |
• | the election by any collaborator to pursue research, development and commercialization activities; |
• | our ability to obtain future reimbursement and/or milestone payments from our collaborators; |
• | our ability to attract collaborators with development, regulatory and commercialization expertise; |
• | our ability to obtain and maintain intellectual property protection for lumateperone or our other product candidates; |
• | our ability to successfully commercialize lumateperone and our other product candidates; |
• | the size and growth of the markets for lumateperone and our other product candidates and our ability to serve those markets; |
• | the rate and degree of market acceptance of any future products; |
• | the success of competing drugs that are or become available; |
• | regulatory developments in the United States and other countries; |
• | the performance of our third-party suppliers and manufacturers and our ability to obtain alternative sources of raw materials; |
• | our ability to obtain additional financing; |
• | our use of the proceeds from our securities offerings; |
• | any restrictions on our ability to use our net operating loss carryforwards; |
• | our exposure to investment risk, interest rate risk and capital market risk; and |
• | our ability to attract and retain key scientific or management personnel. |
Item 1B.
|
UNRESOLVED STAFF COMMENTS
|
Item 2.
|
PROPERTIES
|
Item 3.
|
LEGAL PROCEEDINGS
|
Item 4.
|
MINE SAFETY DISCLOSURES
|
Item 5.
|
MARKET FOR REGISTRANT’S COMMON EQUITY, RELATED STOCKHOLDER MATTERS AND ISSUER PURCHASES OF EQUITY SECURITIES
|
Item 6.
|
SELECTED FINANCIAL DATA
|
|
2019
|
|
2018
|
|
2017
|
|
2016
|
|
2015
|
|
||||||||||
Statements of Operations:
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|||||
Revenues:
|
|
|
|
|
|
|||||||||||||||
License and collaboration revenue
|
$ |
—
|
$ |
—
|
$ |
—
|
$ |
—
|
$ |
30,659
|
||||||||||
Grant revenue
|
60,613
|
—
|
245,837
|
330,702
|
60,705
|
|||||||||||||||
Total Revenues
|
60,613
|
—
|
245,837
|
330,702
|
91,364
|
|||||||||||||||
Costs and expenses:
|
|
|
|
|
|
|||||||||||||||
Research and development
|
89,124,838
|
132,166,913
|
79,419,009
|
93,831,530
|
87,718,074
|
|||||||||||||||
General and administrative
|
64,947,625
|
30,099,855
|
23,666,957
|
24,758,063
|
18,187,286
|
|||||||||||||||
Total costs and expenses
|
154,072,463
|
162,266,768
|
103,085,966
|
118,589,593
|
105,905,360
|
|||||||||||||||
Loss from operations
|
(154,011,850
|
) |
(162,266,768
|
) |
(102,840,129
|
) |
(118,258,891
|
) |
(105,813,996
|
) | ||||||||||
Interest income
|
(6,291,272
|
) |
(7,140,957
|
) |
(4,005,864
|
) |
(2,935,077
|
) |
(1,022,455
|
) | ||||||||||
Interest expense
|
—
|
—
|
—
|
36,781
|
—
|
|||||||||||||||
Income tax expense (benefit)
|
1,600
|
1,600
|
(1,060,851
|
) |
1,065,673
|
1,600
|
||||||||||||||
Net Loss
|
$ |
(147,722,178
|
) | $ |
(155,127,411
|
) | $ |
(97,773,414
|
) | $ |
(116,426,268
|
) | $ |
(104,793,141
|
) | |||||
Net Loss per common share
|
$ |
(2.68
|
) | $ |
(2.84
|
) | $ |
(2.12
|
) | $ |
(2.69
|
) | $ |
(2.91
|
) | |||||
Weighted average number of common shares:
|
55,186,206
|
54,707,865
|
46,181,926
|
43,240,188
|
36,069,237
|
|||||||||||||||
|
December 31,
|
|||||||||||||||||||
|
2019
|
|
2018
|
|
2017
|
|
2016
|
|
2015
|
|
||||||||||
Balance Sheet data:
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|||||
Cash and cash equivalents
|
$ |
107,636,849
|
$ |
54,947,502
|
$ |
37,790,114
|
$ |
48,642,225
|
$ |
47,159,303
|
||||||||||
Investments
|
116,373,335
|
292,583,046
|
426,540,921
|
335,458,459
|
428,041,021
|
|||||||||||||||
Total assets
|
251,186,476
|
357,206,498
|
471,486,699
|
388,903,495
|
484,103,528
|
|||||||||||||||
Total liabilities
|
56,179,205
|
39,491,617
|
17,049,738
|
13,400,956
|
7,860,617
|
|||||||||||||||
Accumulated deficit
|
(710,098,369
|
) |
(562,376,191
|
) |
(407,248,780
|
) |
(309,475,366
|
) |
(193,049,098
|
) | ||||||||||
Total stockholders’ equity
|
195,007,271
|
317,714,881
|
454,436,961
|
375,502,539
|
476,242,911
|
Item 7.
|
MANAGEMENT’S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION AND RESULTS OF OPERATIONS
|
Discussions of year-over-year comparisons between 2018 and 2017 that are not included in this Form 10-K can be found in Part II, Item 7, “Management’s Discussion and Analysis of Financial Condition and Results of Operations” of the Company’s Annual Report on Form 10-K for the fiscal year ended December 31, 2018.
• | internal recurring costs, such as costs relating to labor and fringe benefits, materials, supplies, facilities and maintenance; and |
• |
fees paid to external parties who provide us with contract services, such as
pre-clinical
testing, manufacturing and related testing, clinical trial activities and license milestone payments.
|
• | salaries and related benefit costs; |
• | patent, legal, and professional costs; and |
• | office and facilities overhead. |
• | salaries and related benefit costs of a dedicated sales force; |
• | sales operation costs; and |
• | marketing and promotion expenses. |
|
For the Year Ended December 31,
|
|||||||||||
|
2019
|
|
2018
|
|
2017
|
|
||||||
Revenues
|
$
|
61
|
|
$ |
—
|
$ |
246
|
|||||
Expenses
|
|
|
|
|
|
|
|
|
|
|||
Research and Development
|
|
89,125
|
|
132,167
|
79,419
|
|||||||
General and Administrative
|
|
64,948
|
|
30,099
|
23,667
|
|||||||
Total costs & expenses
|
|
154,073
|
|
162,266
|
103,086
|
|||||||
Loss from operations
|
|
(154,012
|
)
|
(162,266
|
) |
(102,840
|
) | |||||
Interest income, net
|
|
(6,292
|
)
|
(7,141
|
) |
(4,006
|
) | |||||
Income tax expense (benefit)
|
|
2
|
|
2
|
(1,061
|
) | ||||||
Net Loss
|
$
|
(147,722
|
)
|
$ |
(155,127
|
) | $ |
(97,773
|
) | |||
|
2019
|
|
2018
|
|
||||
External Costs
|
$
|
59,141
|
|
$ |
110,700
|
|||
Internal Costs
|
|
29,984
|
|
21,467
|
||||
Total Research and Development Expenses
|
$
|
89,125
|
|
$ |
132,167
|
|||
|
2019
|
|
2018
|
|
||||
Lumateperone costs
|
$
|
37,121
|
|
$ |
82,288
|
|||
Manufacturing costs
|
|
20,684
|
|
22,741
|
||||
Stock based compensation
|
|
9,411
|
|
7,381
|
||||
Other projects and overhead
|
|
21,909
|
|
19,757
|
||||
Total Research and Development Expenses
|
$
|
89,125
|
|
$ |
132,167
|
|||
• |
completion of extensive
pre-clinical
laboratory tests, animal studies, and formulation studies in accordance with the FDA’s Good Laboratory Practice, or GLP, regulations;
|
• | submission to the FDA of an Investigational New Drug application, or IND, for human clinical testing, which must become effective before human clinical trials may begin; |
• | performance of adequate and well-controlled human clinical trials to establish the safety and efficacy of the drug for each proposed indication; |
• | submission to the FDA of a New Drug Application, or NDA, after completion of all clinical trials; |
• |
satisfactory completion of an FDA
pre-approval
inspection of the manufacturing facility or facilities at which the active pharmaceutical ingredient, or API, and finished drug product are produced and tested to assess compliance with current Good Manufacturing Practices, or cGMPs;
|
• | satisfactory completion of FDA inspections of clinical trial sites to assure that data supporting the safety and effectiveness of product candidates has been generated in compliance with Good Clinical Practices; and |
• | FDA review and approval of the NDA prior to any commercial marketing or sale of the drug in the United States. |
|
Payments Due By Period
|
|||||||||||||||||||
|
Total
|
|
2020
|
|
2021-2022
|
|
2023-2025
|
|
After 2025
|
|
||||||||||
Operating Lease Obligations
|
$ |
35,155
|
$ |
3,346
|
$ |
6,940
|
$ |
11,029
|
$ |
13,840
|
Item 7A.
|
QUANTITATIVE AND QUALITATIVE DISCLOSURES ABOUT MARKET RISK
|
Item 8.
|
FINANCIAL STATEMENTS AND SUPPLEMENTARY DATA
|
Index to Financial Statements and Financial Statement Schedules
|
Number
|
|||
F-
1
|
||||
F-
3
|
||||
F-
4
|
||||
F-
5
|
||||
F-
6
|
||||
F-
7
|
||||
F-
8
|
Item 9.
|
CHANGES IN AND DISAGREEMENTS WITH ACCOUNTANTS ON ACCOUNTING AND FINANCIAL DISCLOSURE
|
Item 9A.
|
CONTROLS AND PROCEDURES
|
• | pertain to the maintenance of records that, in reasonable detail, accurately and fairly reflect the transactions and dispositions of the assets of the Company; |
• | provide reasonable assurance that transactions are recorded as necessary to permit preparation of financial statements in accordance with generally accepted accounting principles, and that receipts and expenditures of the Company are being made only in accordance with authorizations of management and directors of the Company; and |
• | provide reasonable assurance regarding prevention or timely detection of unauthorized acquisition, use or disposition of the Company’s assets that could have a material effect on the financial statements. |
Item 9B.
|
OTHER INFORMATION
|
Item 10.
|
DIRECTORS, EXECUTIVE OFFICERS AND CORPORATE GOVERNANCE
|
Item 11.
|
EXECUTIVE COMPENSATION
|
Item 12.
|
SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENT AND RELATED STOCKHOLDER MATTERS
|
Item 13.
|
CERTAIN RELATIONSHIPS AND RELATED TRANSACTIONS, AND DIRECTOR INDEPENDENCE
|
Item 14.
|
PRINCIPAL ACCOUNTING FEES AND SERVICES
|
Item 15.
|
EXHIBITS, FINANCIAL STATEMENT SCHEDULES
|
|
Item 15(a).
|
The following documents are filed as part of this annual report on Form
10-K:
|
|
Item 15(a)(1)
and (2) |
See “Index to Consolidated Financial Statements and Financial Statement Schedules” at Item 8 to this Annual Report on Form
10-K.
Other financial statement schedules have not been included because they are not applicable or the information is included in the financial statements or notes thereto.
|
|
Item 15(a)(3)
|
Exhibits
|
Exhibit
Number |
|
|
|
Exhibit Description
|
Filed
Herewith |
Incorporated
by Reference herein from Form or Schedule |
Filing Date
|
SEC File/
Reg. Number |
|
|||||||||
2.1
|
|
|
8-K
(Exhibit 2.1)
|
8/29/2013
|
000-54896
|
|||||||||||||
2.2
|
|
|
8-K
(Exhibit 2.2)
|
9/5/2013
|
000-54896
|
|||||||||||||
3.1
|
|
|
S-1/A
(Exhibit 3.1)
|
11/26/13
|
333-191238
|
|||||||||||||
3.2
|
|
|
8-K
(Exhibit 3.3)
|
9/5/2013
|
000-54896
|
|||||||||||||
3.3
|
|
|
8-K
(Exhibit 3.4)
|
9/5/2013
|
000-54896
|
|||||||||||||
3.4
|
|
|
8-K
(Exhibit 3.5)
|
9/5/2013
|
000-54896
|
|||||||||||||
4.1
|
|
|
8-K
(Exhibit 4.1)
|
9/5/2013
|
000-54896
|
|||||||||||||
4.2
|
|
X
|
|
|
|
Exhibit
Number |
|
|
|
Exhibit Description
|
Filed
Herewith |
Incorporated
by Reference herein from Form or Schedule |
Filing Date
|
SEC File/
Reg. Number |
|
|||||||||
10.1
|
.1
|
|
8-K/A
(Exhibit 10.1.1)
|
10/31/2013
|
000-54896
|
|||||||||||||
|
.2
|
|
8-K
(Exhibit 10.1.2)
|
9/5/2013
|
000-54896
|
|||||||||||||
10.2
|
|
|
10-K
(Exhibit 10.3)
|
3/1/2017
|
001-36274
|
|||||||||||||
10.3
|
|
|
Form
S-3
(Exhibit 1.2)
|
8/30/2019
|
333-233537
|
|||||||||||||
10.4
|
|
|
8-K
(Exhibit 10.3)
|
9/5/2013
|
000-54896
|
|||||||||||||
10.5
|
.1
|
|
10-Q
(Exhibit 10.1)
|
11/5/2015
|
001-36274
|
|||||||||||||
|
.2
|
|
10-Q
(Exhibit 10.1)
|
11/9/2016
|
001-36274
|
|||||||||||||
10.6
|
|
|
8-K
(Exhibit 10.4)
|
9/5/2013
|
001-36274
|
|||||||||||||
10.7
|
.1
|
|
10-K
(Exhibit 10.6)
|
2/25/2016
|
001-36274
|
|||||||||||||
|
.2
|
|
10-Q
(Exhibit 10.2)
|
11/9/2016
|
001-36274
|
Exhibit
Number |
|
|
|
Exhibit Description
|
Filed
Herewith |
Incorporated
by Reference herein from Form or Schedule |
Filing Date
|
SEC File/
Reg. Number |
|
|||||||||
10.8
|
.1
|
|
10-K
(Exhibit 10.7)
|
2/25/2016
|
000-54896
|
|||||||||||||
|
.2
|
|
10-Q
(Exhibit 10.3)
|
11/9/2016
|
001-36274
|
|||||||||||||
10.9
|
|
|
10-K
(Exhibit 10.8)
|
3/1/2018
|
001-36274
|
|||||||||||||
10.10
|
|
|
10-K
(Exhibit 10.9)
|
2/27/2019
|
001-36274
|
|||||||||||||
10.11
|
|
|
8-K
(Exhibit 10.8)
|
9/5/2013
|
000-54896
|
|||||||||||||
10.12
|
|
|
10-K
(Exhibit 10.11)
|
3/12/2015
|
001-36274
|
|||||||||||||
10.13
|
|
|
8-K
(Exhibit 10.9)
|
9/5/2013
|
000-54896
|
|||||||||||||
10.14
|
|
|
10-K
(Exhibit 10.11)
|
2/25/2016
|
001-36274
|
|||||||||||||
10.15
|
|
|
8-K
(Exhibit 10.12)
|
9/5/2013
|
000-54896
|
Exhibit
Number |
|
|
|
Exhibit Description
|
Filed
Herewith |
Incorporated
by Reference herein from Form or Schedule |
Filing Date
|
SEC File/
Reg. Number |
|
|||||||||
10.16
|
|
|
10-K
(Exhibit 10.14)
|
3/1/2018
|
001-36274
|
|||||||||||||
10.17
|
|
|
10-K
(Exhibit 10.16)
|
2/27/2019
|
001-36274
|
|||||||||||||
10.18
|
|
|
8-K
(Exhibit 10.13)
|
9/5/2013
|
000-54896
|
|||||||||||||
10.19
|
|
|
8-K
(Exhibit 10.14)
|
9/5/2013
|
000-54896
|
|||||||||||||
10.20
|
|
|
8-K
(Exhibit 10.15)
|
9/5/2013
|
000-54896
|
|||||||||||||
10.21
|
|
|
8-K
(Exhibit 10.1)
|
6/18/2015
|
001-36274
|
|||||||||||||
10.22
|
|
|
10-K
(Exhibit 10.19)
|
3/25/2014
|
001-36274
|
|||||||||||||
10.23
|
|
|
8-K
(Exhibit 10.1)
|
6/21/2018
|
001-36274
|
|||||||||||||
10.24
|
|
|
8-K
(Exhibit 10.2)
|
6/21/2018
|
001-36274
|
|||||||||||||
10.25
|
|
|
8-K
(Exhibit 10.3)
|
6/21/2018
|
001-36274
|
|||||||||||||
10.26
|
|
|
8-K
(Exhibit 10.4)
|
6/21/2018
|
001-36274
|
|||||||||||||
10.27
|
|
|
8-K
(Exhibit 10.5)
|
6/21/2018
|
001-36274
|
|||||||||||||
10.28
|
|
X
|
|
|
|
Exhibit
Number |
|
|
|
Exhibit Description
|
Filed
Herewith |
Incorporated
by Reference herein from Form or Schedule |
Filing Date
|
SEC File/
Reg. Number |
|
|||||||||
10.29
|
|
|
8-K
(Exhibit 10.17)
|
9/5/2013
|
000-54896
|
|||||||||||||
10.30
|
|
|
8-K
(Exhibit 10.18)
|
9/5/2013
|
000-54896
|
|||||||||||||
10.31
|
|
|
8-K
(Exhibit 10.19)
|
9/5/2013
|
000-54896
|
|||||||||||||
10.32
|
|
X
|
|
|
|
|||||||||||||
10.33
|
|
X
|
|
|
|
|||||||||||||
10.34
|
|
X
|
|
|
|
|||||||||||||
21.1
|
|
|
10-K
(Exhibit 21.1)
|
3/1/2017
|
001-36274
|
|||||||||||||
23.1
|
|
X
|
|
|
|
|||||||||||||
31.1
|
|
X
|
|
|
|
|||||||||||||
31.2
|
|
X
|
|
|
|
|||||||||||||
32.1
|
|
X
|
|
|
|
|||||||||||||
101
|
.INS
|
Inline XBRL Instance Document—the instance document does not appear in the Interactive Data File because its XBRL tags are embedded within the Inline XBRL document.
|
X
|
|
|
|
||||||||||||
|
.SCH
|
Inline XBRL Taxonomy Extension Schema Document.
|
X
|
|
|
|
||||||||||||
|
.CAL
|
Inline XBRL Taxonomy Extension Calculation Linkbase Document.
|
X
|
|
|
|
||||||||||||
|
.DEF
|
Inline XBRL Taxonomy Extension Definition.
|
X
|
|
|
|
||||||||||||
|
.LAB
|
Inline XBRL Taxonomy Extension Label Linkbase Document.
|
X
|
|
|
|
Exhibit
Number |
|
|
|
Exhibit Description
|
Filed
Herewith |
Incorporated
by Reference herein from Form or Schedule |
Filing Date
|
SEC File/
Reg. Number |
|
|||||||||
|
.PRE
|
Inline XBRL Taxonomy Presentation Linkbase Document.
|
X
|
|
|
|
||||||||||||
104
|
|
Cover Page Interactive Date File (formatted as Inline XBRL and contained in Exhibit 101).
|
X
|
|
|
|
* | Management contract or compensatory plan or arrangement. |
** | Confidential treatment has been granted for portions of this Exhibit. Redacted portions filed separately with the Securities and Exchange Commission. |
Item 16.
|
FORM
10-K
SUMMARY
|
|
INTRA-CELLULAR THERAPIES, INC.
|
|||||
Date: March 2, 2020
|
By:
|
/s/ Sharon Mates, Ph.D.
|
||||
|
|
Sharon Mates, Ph.D.
|
||||
|
|
Chairman, President and Chief Executive Officer
|
Signatures
|
Title
|
Date
|
||||
By:
|
/s/ Sharon Mates, Ph.D.
Sharon Mates, Ph.D.
|
Chairman, President and Chief Executive Officer (principal executive officer)
|
March 2, 2020
|
|||
By:
|
/s/ Lawrence J. Hineline
Lawrence J. Hineline
|
Senior Vice President of Finance and Chief Financial Officer (principal financial officer and principal accounting officer)
|
March 2, 2020
|
|||
By:
|
/s/ Christopher Alafi, Ph.D.
Christopher Alafi, Ph.D.
|
Director
|
March 2, 2020
|
|||
By:
|
/s/ Richard Lerner, M.D.
Richard Lerner, M.D.
|
Director
|
March 2, 2020
|
|||
By:
|
/s/ Joel S. Marcus
Joel S. Marcus
|
Director
|
March 2, 2020
|
|||
By:
|
/s/ Rory B. Riggs
Rory B. Riggs
|
Director
|
March 2, 2020
|
|||
By:
|
/s/ Robert L. Van Nostrand
Robert L. Van Nostrand
|
Director
|
March 2, 2020
|
|
Clinical trial expenses
|
|
Description of the Matter
|
As described in Note 2 to the consolidated financial statements, at each consolidated balance sheet date the Company is required to estimate its expenses resulting from its obligations under contracts with vendors, clinical research organizations and consultants and under clinical site agreements in connection with conducting clinical trials. The Company recorded accrued expenses for the clinical trial accruals, which are included in accrued and other current liabilities on the December 31, 2019 consolidated balance sheet and also recorded prepaid clinical trial expenses, which are included in prepaid expenses and other current assets on the December 31, 2019 consolidated balance sheet. The amounts recorded for clinical trial accruals and for prepaid clinical trial expenses, within the aforementioned balance sheet captions represent the Company’s estimate of the unpaid and prepaid clinical trial expenses based on the
Auditing the Company’s clinical trial accruals and prepaid clinical trial expenses involved a high degree of subjectivity due to the significant estimation required in determining the progress to completion of specific tasks conducted under its clinical trials and the costs of those tasks that will be invoiced by the vendors, clinical research organizations and consultants and under clinical site agreements subsequent to the date that the consolidated financial statements are issued.
|
|
How We Addressed the Matter in Our Audit
|
We obtained an understanding, evaluated the design, and tested the operating effectiveness of controls over the Company’s estimation of the clinical trial expenses, including the process of estimating the expenses incurred to date based on the status of the clinical trials. For example, we tested controls over management’s review of the clinical trial expense calculation, the significant assumptions about the status of research and development services incurred, and the completeness and accuracy of the data used to calculate the estimates.
To test the clinical trial accruals and prepaid clinical trial expenses, we performed procedures that included, among others, reading each agreement and change order with the vendors, clinical research organizations and consultants, and under clinical site agreements, and evaluating the significant assumptions described above and the methods used in developing the clinical trial estimates and calculating the amounts that were unpaid and prepaid at the balance sheet date. We made direct inquiries of financial and clinical personnel on the status of the clinical trials, progress to completion of clinical trials, method of allocating contractual charges to specific tasks performed during the clinical trials, and the status of change orders. We compared the current estimate of expenses incurred to estimates previously made my management. We also assessed the historical accuracy of management’s estimates and examined payments made to service providers after the consolidated balance sheet date.
|
|
December 31,
|
|||||||
|
2019
|
|
2018
|
|||||
Assets
|
|
|
|
|
|
|
||
Current assets:
|
|
|
||||||
Cash and cash equivalents
|
$
|
107,636,849
|
|
$ |
54,947,502
|
|||
Investment securities,
available-for-sale
|
|
116,373,335
|
|
292,583,046
|
||||
Prepaid expenses and other current assets
|
|
6,313,785
|
|
7,908,133
|
||||
Total current assets
|
|
230,323,969
|
|
355,438,681
|
||||
Property and equipment, net
|
|
2,259,740
|
|
1,159,766
|
||||
Right of use assets, net
|
|
18,252,074
|
|
—
|
||||
Deferred tax asset, net
|
|
264,609
|
|
529,218
|
||||
Other assets
|
|
86,084
|
|
78,833
|
||||
Total assets
|
$
|
251,186,476
|
|
$ |
357,206,498
|
|||
Liabilities and stockholders’ equity
|
|
|
|
|
|
|
||
Current liabilities:
|
|
|
|
|
||||
Accounts payable
|
$
|
7,425,024
|
|
$ |
13,961,060
|
|||
Accrued and other current liabilities
|
|
16,138,909
|
|
20,044,866
|
||||
Lease liabilities, short-term
|
|
3,187,435
|
|
—
|
||||
Accrued employee benefits
|
|
9,472,651
|
|
2,293,259
|
||||
Total current liabilities
|
|
36,224,019
|
|
36,299,185
|
||||
Deferred rent
|
|
—
|
|
3,192,432
|
||||
Lease liabilities
|
|
19,955,186
|
|
—
|
||||
Total liabilities
|
|
56,179,205
|
|
39,491,617
|
||||
Stockholders’ equity:
|
|
|
|
|
||||
Common stock, $0.0001 par value: 100,000,000 shares authorized; 55,507,497 and 54,895,295 shares issued and outstanding at December 31, 2019 and December 31, 2018, respectively
|
|
5,551
|
|
5,490
|
||||
Additional
paid-in
capital
|
|
904,971,772
|
|
880,753,339
|
||||
Accumulated deficit
|
|
(710,098,369
|
)
|
(562,376,191
|
) | |||
Accumulated comprehensive gain/(loss)
|
|
128,317
|
|
(667,757
|
) | |||
Total stockholders’ equity
|
|
195,007,271
|
|
317,714,881
|
||||
Total liabilities and stockholders’ equity
|
$
|
251,186,476
|
|
$ |
357,206,498
|
|||
|
Years Ended December 31,
|
|||||||||||
|
2019
|
|
2018
|
|
2017
|
|
||||||
Grant revenue
|
$
|
60,613
|
|
$ |
—
|
$ |
245,837
|
|||||
Costs and expenses:
|
|
|
|
|
|
|||||||
Research and development
|
|
89,124,838
|
|
132,166,913
|
79,419,009
|
|||||||
General and administrative
|
|
64,947,625
|
|
30,099,855
|
23,666,957
|
|||||||
Total costs and expenses
|
|
154,072,463
|
|
162,266,768
|
103,085,966
|
|||||||
Loss from operations
|
|
(154,011,850
|
)
|
(162,266,768
|
) |
(102,840,129
|
) | |||||
Interest income
|
|
(6,291,272
|
)
|
(7,140,957
|
) |
(4,005,864
|
) | |||||
Loss before provision (benefit) for income taxes
|
|
(147,720,578
|
)
|
(155,125,811
|
) |
(98,834,265
|
) | |||||
Income tax expense (benefit)
|
|
1,600
|
|
1,600
|
(1,060,851
|
) | ||||||
Net loss
|
$
|
(147,722,178
|
)
|
$ |
(155,127,411
|
) | $ |
(97,773,414
|
) | |||
Net loss per common share:
|
|
|
|
|
|
|||||||
Basic & Diluted
|
(2.68
|
)
|
$ |
(2.84
|
) | $ |
(2.12
|
) | ||||
Weighted average number of common shares:
|
|
|
|
|
|
|||||||
Basic & Diluted
|
|
55,186,206
|
|
54,707,865
|
46,181,926
|
|
Years Ended December 31,
|
|||||||||||
|
2019
|
|
2018
|
|
|
2017
|
||||||
Net loss
|
$
|
(147,722,178
|
)
|
$ |
(155,127,411
|
) | $ |
(97,773,414
|
) | |||
Other comprehensive income (loss):
|
|
|
|
|||||||||
Unrealized gain (loss) on investment securities
|
|
796,074
|
|
131,467
|
(481,985
|
) | ||||||
Comprehensive loss
|
$
|
(146,926,104
|
)
|
$ |
(154,995,944
|
) | $ |
(98,255,399
|
) | |||
|
Common Stock
|
Additional
Paid-in
Capital |
|
Accumulated
Deficit |
|
Accumulated
Comprehensive Gain (Loss) |
|
Total
Stockholders’ Equity |
|
|||||||||||||||
|
Shares
|
|
Amount
|
|
||||||||||||||||||||
Balance at December 31, 2016
|
43,292,906
|
$ |
4,329
|
$ |
685,290,815
|
$ |
(309,475,366
|
) | $ |
(317,239
|
) | $ |
375,502,539
|
|||||||||||
Common shares issued October 2017
|
11,129,032
|
1,113
|
162,071,143
|
—
|
—
|
162,072,256
|
||||||||||||||||||
Exercise of stock options and vesting of restricted stock
|
162,642
|
17
|
285,143
|
—
|
—
|
285,160
|
||||||||||||||||||
Stock issued for services
|
13,099
|
1
|
190,884
|
—
|
—
|
190,885
|
||||||||||||||||||
Share-based compensation
|
—
|
—
|
14,641,520
|
—
|
—
|
14,641,520
|
||||||||||||||||||
Net loss
|
—
|
—
|
—
|
(97,773,414
|
) |
—
|
(97,773,414
|
) | ||||||||||||||||
Other comprehensive loss
|
—
|
—
|
—
|
—
|
(481,985
|
) |
(481,985
|
) | ||||||||||||||||
Balance at December 31, 2017
|
54,597,679
|
$ |
5,460
|
$ |
862,479,505
|
$ |
(407,248,780
|
) | $ |
(799,224
|
) | $ |
454,436,961
|
|||||||||||
Exercise of stock options and vesting of restricted stock
|
284,326
|
29
|
674,177
|
—
|
—
|
674,206
|
||||||||||||||||||
Stock issued for services
|
11,468
|
1
|
192,529
|
—
|
—
|
192,530
|
||||||||||||||||||
Share-based compensation
|
—
|
—
|
17,396,146
|
—
|
—
|
17,396,146
|
||||||||||||||||||
Stock warrant
|
1,822
|
—
|
10,982
|
—
|
—
|
10,982
|
||||||||||||||||||
Net loss
|
—
|
—
|
—
|
(155,127,411
|
) |
—
|
(155,127,411
|
) | ||||||||||||||||
Other comprehensive income
|
—
|
—
|
—
|
—
|
131,467
|
131,467
|
||||||||||||||||||
Balance at December 31, 2018
|
54,895,295
|
|
|
$
|
5,490
|
|
|
$
|
880,753,339
|
|
|
$
|
(562,376,191
|
)
|
|
$
|
(667,757
|
)
|
|
$
|
317,714,881
|
|||
Exercise of stock options and vesting of restricted stock
|
|
596,558
|
|
|
|
59
|
|
|
|
3,235,542
|
|
|
|
—
|
|
|
|
—
|
|
|
|
3,235,601
|
|
|
Stock issued for services
|
|
15,644
|
|
|
|
2
|
|
|
|
194,203
|
|
|
|
—
|
|
|
|
—
|
|
|
|
194,205
|
|
|
Share-based compensation
|
|
—
|
|
|
|
—
|
|
|
|
20,788,688
|
|
|
|
—
|
|
|
|
—
|
|
|
|
20,788,688
|
|
|
Net loss
|
|
—
|
|
|
|
—
|
|
|
|
—
|
|
|
|
(147,722,178
|
)
|
|
|
—
|
|
|
|
(147,722,178
|
)
|
|
Other comprehensive
income
|
|
—
|
|
|
|
—
|
|
|
|
—
|
|
|
|
—
|
|
|
|
796,074
|
|
|
|
796,074
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
||||
Balance at December 31, 2019
|
|
55,507,497
|
|
|
$
|
5,551
|
|
|
$
|
904,971,772
|
|
|
$
|
(710,098,369
|
)
|
|
$
|
128,317
|
|
|
$
|
195,007,271
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Years Ended December 31,
|
|||||||||||
|
2019
|
|
2018
|
|
|
2017
|
||||||
Operating activities
|
|
|
|
|
|
|
|
|
|
|||
Net loss
|
$
|
(147,722,178
|
)
|
$ |
(155,127,411
|
) | $ |
(97,773,414
|
) | |||
Adjustments to reconcile net loss to net cash used in operating activities:
|
|
|
|
|
|
|||||||
Depreciation expense
|
|
477,121
|
|
368,673
|
213,872
|
|||||||
Share-based compensation
|
|
20,788,688
|
|
17,396,146
|
14,641,520
|
|||||||
Stock issued for services
|
|
194,205
|
|
192,530
|
190,885
|
|||||||
Amortization of premiums and discounts on investment activities
|
|
(1,131,597
|
)
|
(943,239
|
) |
429,839
|
||||||
Changes in operating assets and liabilities:
|
|
|
|
|
|
|||||||
Accounts receivable
|
|
—
|
|
—
|
94,339
|
|||||||
Prepaid expenses and other assets
|
|
1,465,384
|
|
(3,026,908
|
) |
(879,200
|
) | |||||
Long term deferred tax asset, net
|
|
264,609
|
|
529,217
|
(1,058,435
|
) | ||||||
Accounts payable
|
|
(6,536,036
|
)
|
7,787,521
|
2,418,892
|
|||||||
Accrued liabilities and employee benefits
|
|
3,327,095
|
|
14,386,774
|
1,211,103
|
|||||||
Lease liabilities
, net
|
|
|
889,468
|
|
|
|
—
|
|
|
|
—
|
|
Deferred rent
|
|
—
|
|
267,584
|
18,787
|
|||||||
Net cash used in operating activities
|
|
(127,983,241
|
)
|
(118,169,113
|
) |
(80,491,812
|
) | |||||
Investing activities
|
|
|
|
|
|
|
|
|
|
|||
Purchases of investments
|
|
(80,720,301
|
)
|
(271,156,707
|
) |
(520,926,824
|
) | |||||
Maturities of investments
|
|
258,857,683
|
|
406,189,288
|
428,932,538
|
|||||||
Purchases of property and equipment
|
|
(700,395
|
)
|
(391,268
|
) |
(723,429
|
) | |||||
Net cash provided by (used in) investing activities
|
|
177,436,987
|
|
134,641,313
|
(92,717,715
|
) | ||||||
Financing activities
|
|
|
|
|
|
|
|
|
|
|||
Exercise of stock options
|
|
3,235,601
|
|
674,206
|
285,160
|
|||||||
Proceeds of public offerings, net
|
|
—
|
|
—
|
162,072,256
|
|||||||
Proceeds from stock warrant
|
|
—
|
|
10,982
|
—
|
|||||||
Net cash provided by financing activities
|
|
3,235,601
|
|
685,188
|
162,357,416
|
|||||||
Net increase (decrease) in cash and cash equivalents
|
|
52,689,347
|
|
17,157,388
|
(10,852,111
|
) | ||||||
Cash and cash equivalents at beginning of period
|
|
54,947,502
|
|
37,790,114
|
48,642,225
|
|||||||
Cash and cash equivalents at end of period
|
$
|
107,636,849
|
|
$ |
54,947,502
|
$ |
37,790,114
|
|||||
Cash paid for taxes
|
$
|
1,600
|
|
$ |
1,600
|
$ |
1,600
|
|||||
|
December 31, 2019
|
|||||||||||||||
|
Amortized
Cost |
|
Unrealized
Gains |
|
Unrealized
(Losses) |
|
Estimated
Fair Value |
|
||||||||
U.S. Government Agency Securities
|
$ |
35,462
|
$ |
35
|
$ |
(3
|
) | $ |
35,494
|
|||||||
Certificates of Deposit
|
3,000
|
—
|
—
|
3,000
|
||||||||||||
Commercial Paper
|
39,013
|
10
|
(5
|
) |
39,018
|
|||||||||||
Corporate Notes/Bonds
|
38,770
|
91
|
—
|
38,861
|
||||||||||||
|
$ |
116,245
|
$ |
136
|
$ |
(8
|
) | $ |
116,373
|
|||||||
|
December 31, 2018
|
|||||||||||||||
|
Amortized
Cost |
|
Unrealized
Gains |
|
Unrealized
(Losses) |
|
Estimated
Fair Value |
|
||||||||
U.S. Government Agency Securities
|
$ |
124,691
|
$ |
24
|
$ |
(289
|
) | $ |
124,426
|
|||||||
FDIC Certificates of Deposit (1)
|
245
|
—
|
—
|
245
|
||||||||||||
Certificates of Deposit
|
1,000
|
—
|
—
|
1,000
|
||||||||||||
Commercial Paper
|
41,317
|
—
|
(45
|
) |
41,272
|
|||||||||||
Corporate Notes/Bonds
|
125,998
|
7
|
(365
|
) |
125,640
|
|||||||||||
|
$ |
293,251
|
$ |
31
|
$ |
(699
|
) | $ |
292,583
|
|||||||
(1) | “FDIC Certificates of Deposit” consist of deposits that are $250,000 or less. |
• | Level 1—Fair value is determined by using unadjusted quoted prices that are available in active markets for identical assets and liabilities. |
• | Level 2—Fair value is determined by using inputs other than Level 1 quoted prices that are directly or indirectly observable. Inputs can include quoted prices for similar assets and liabilities in active markets or quoted prices for identical assets and liabilities in inactive markets. Related inputs can also include those used in valuation or other pricing models, such as interest rates and yield curves that can be corroborated by observable market data. |
• | Level 3—Fair value is determined by inputs that are unobservable and not corroborated by market data. Use of these inputs involves significant and subjective judgments to be made by a reporting entity—e.g., determining an appropriate adjustment to a discount factor for illiquidity associated with a given security. |
|
|
|
Fair Value Measurements at
Reporting Date Using |
|||||||||||||
|
December 31,
2019 |
|
Quoted Prices
in Active Markets for Identical Assets (Level 1) |
|
Significant
Other Observable Inputs (Level 2) |
|
Significant
Unobservable Inputs (Level 3) |
|
||||||||
Money market funds
|
$ |
49,882
|
$ |
49,882
|
$ |
—
|
$ |
—
|
||||||||
U.S. government agency securities
|
35,494
|
—
|
35,494
|
—
|
||||||||||||
Certificates of deposit
|
50,622
|
—
|
50,622
|
—
|
||||||||||||
Commercial paper
|
42,015
|
—
|
42,015
|
—
|
||||||||||||
Corporate bonds/notes
|
38,861
|
—
|
38,861
|
—
|
||||||||||||
|
$ |
216,874
|
$ |
49,882
|
$ |
166,992
|
$ |
—
|
||||||||
|
|
|
Fair Value Measurements at
Reporting Date Using |
|||||||||||||
|
December 31,
2018 |
|
Quoted Prices
in Active Markets for Identical Assets (Level 1) |
|
Significant
Other Observable Inputs (Level 2) |
|
Significant
Unobservable Inputs (Level 3) |
|
||||||||
Money market funds
|
$ |
39,591
|
$ |
39,591
|
$ |
—
|
$ |
—
|
||||||||
U.S. government agency securities
|
124,426
|
—
|
124,426
|
—
|
||||||||||||
FDIC certificates of deposit
|
245
|
—
|
245
|
—
|
||||||||||||
Certificates of deposit
|
8,500
|
—
|
8,500
|
—
|
||||||||||||
Commercial paper
|
41,272
|
—
|
41,272
|
—
|
||||||||||||
Corporate bonds/notes
|
125,640
|
—
|
125,640
|
—
|
||||||||||||
|
$ |
339,674
|
$ |
39,591
|
$ |
300,083
|
$ |
—
|
||||||||
|
Year Ended December 31,
|
|||||||||||
|
2019
|
|
2018
|
|
2017
|
|
||||||
Common Stock Equivalents
|
6,039,945
|
4,748,391
|
3,755,739
|
|||||||||
RSUs
|
1,268,679
|
647,411
|
190,933
|
|||||||||
TSR RSUs
|
67,080
|
206,484
|
347,199
|
|
December 31,
|
|||||||
|
201
9
|
|
2018
|
|
||||
Computer equipment
|
$ |
243,532
|
$ |
44,427
|
||||
Furniture and fixtures
|
423,097
|
341,582
|
||||||
Scientific equipment
|
3,861,227
|
3,658,209
|
||||||
Leasehold improvements
|
1,240,315
|
149,470
|
||||||
|
5,768,171
|
4,193,688
|
||||||
Less accumulated depreciation
|
(3,508,431
|
) |
(3,033,922
|
) | ||||
|
$ |
2,259,740
|
$ |
1,159,766
|
||||
Year ending December 31, 2020
|
3,346,375
|
|||
Year ending December 31, 2021
|
3,448,323
|
|||
Year ending December 31, 2022
|
3,491,166
|
|||
Year ending December 31, 2023
|
3,566,466
|
|||
Year ending December 31, 2024
|
3,675,196
|
|||
Thereafter
|
17,627,040
|
|||
Total
|
35,154,566
|
|||
Less: Present value discount
|
(12,011,945
|
) | ||
Total Lease liability
|
$ |
23,142,621
|
||
Less: current portion
|
(3,187,435
|
) | ||
Long-term lease liabilities
|
$ |
19,955,186
|
||
|
Years Ended December 31,
|
|||||||||||
|
2019
|
|
2018
|
|
|
2017
|
||||||
Research and development
|
$
|
9,411,056
|
|
$ |
7,380,814
|
$ |
5,082,823
|
|||||
General and administrative
|
|
11,377,632
|
|
10,015,332
|
9,558,697
|
|||||||
Total share-based compensation expense
|
$
|
20,788,688
|
|
$ |
17,396,146
|
$ |
14,641,520
|
|||||
|
2019
|
|
2018
|
|
2017
|
|
||||||
Dividend yield
|
|
0
|
%
|
0
|
% |
0
|
% | |||||
Expected volatility
|
|
85.7-96.5
|
%
|
85.2%-85.8
|
% |
87.4%-90.4
|
% | |||||
Weighted-average risk-free interest rate
|
|
2.32
|
%
|
2.48
|
% |
2.1
|
% | |||||
Expected term (in years)
|
|
6.0
|
|
6.0
|
6.0
|
|
Number of
Shares |
|
Weighted-
Average Exercise Price |
|
Weighted-
Average Contractual Life |
|
||||||
Outstanding at December 31, 2018
|
4,748,391
|
$ |
18.26
|
7.0 years
|
||||||||
Options granted
|
1,833,102
|
$ |
12.98
|
9.2 years
|
||||||||
Options exercised
|
(264,663
|
) | $ |
12.22
|
4.1 years
|
|||||||
Options canceled or expired
|
(276,885
|
) | $ |
20.82
|
6.8 years
|
|||||||
Outstanding at December 31, 2019
|
6,039,945
|
$ |
16.81
|
7.0 years
|
||||||||
Vested or expected to vest at December 31, 2019
|
6,039,945
|
$ |
16.81
|
|
||||||||
Exercisable at December 31, 2019
|
3,313,108
|
$ |
19.38
|
5.6 years
|
||||||||
|
Number of
Shares |
|
Weighted-
Average Grant Date Fair Value Per Share |
|
Weighted-
Average Contractual Life |
|
|
|||||
Outstanding at December 31, 2018
|
647,411
|
$ |
18.16
|
|
1.8 years
|
|
||||||
Time based RSUs granted in 2019
|
950,449
|
$ |
12.79
|
|
2.0 years
|
|
||||||
Time based RSUs vested in 2019
|
(267,143
|
) | $ |
21.64
|
|
0.7 years
|
|
|||||
Time based RSUs cancelled in 2019
|
(62,038
|
) | $ |
14.14
|
|
1.4 years
|
|
|||||
|
|
|
||||||||||
Outstanding at December 31, 2019
|
1,268,679
|
$ |
13.60
|
|
1.7 years
|
|
||||||
|
|
|
|
Number of
Shares |
Weighted-
Average
Grant Date Fair Value
Per Share
|
Weighted-
Average Contractual Life |
|||||||||
Outstanding at December 31, 2018
|
278,592
|
$ |
15.35
|
|
1.8 years
|
|
||||||
Milestone RSUs and TSR RSUs
vested
in 2019
|
(65,111
|
) | $ |
14.16
|
|
0.2 years
|
|
|||||
Milestone RSUs and TSR RSUs cancelled in 2019
|
(146,401
|
) | $ |
15.64
|
|
0.2 years
|
|
|||||
|
|
|
||||||||||
Outstanding at December 31, 2019
|
67,080
|
$ |
17.08
|
|
0.2 years
|
|
||||||
|
|
|
|
2019
|
|
2018
|
|
|
2017
|
||||||
U.S.
|
(56,121,258
|
)
|
$ |
(30,299,751
|
) | $ |
(20,486,935
|
) | ||||
Non-U.S.
|
|
(91,599,320
|
)
|
(124,826,060
|
) |
(78,347,330
|
) | |||||
Total loss before taxes
|
(147,720,578
|
)
|
$ |
(155,125,811
|
) | $ |
(98,834,265
|
) | ||||
|
|
2019
|
|
|
2018
|
|
|
2017
|
|
|||
Current
|
$
|
1,600
|
|
$ |
1,600
|
$ |
(2,416
|
) | ||||
Deferred
|
|
(8,484,822
|
)
|
(5,054,468
|
) |
13,713,987
|
||||||
Valuation allowance
|
|
8,484,822
|
|
5,054,468
|
(14,772,422
|
) | ||||||
Provision (benefit) for income taxes
|
$
|
1,600
|
|
$ |
1,600
|
$ |
(1,060,851
|
) | ||||
|
December 31,
|
|||||||||||
|
|
2019
|
|
|
2018
|
|
|
2017
|
|
|||
Income tax benefit at statutory federal rate
|
|
21.00
|
%
|
21.00
|
% |
35.00
|
% | |||||
Other Permanent differences
|
|
(0.67
|
)
|
(0.58
|
) |
(0.43
|
) | |||||
Foreign rate differential
|
|
(13.02
|
)
|
(16.90
|
) |
(27.75
|
) | |||||
2017 US Tax Reform impact
|
|
0.00
|
|
0.00
|
(21.89
|
) | ||||||
R&D Credit
|
|
0.00
|
|
0.00
|
(0.05
|
) | ||||||
Change in effective state tax rates
|
|
(0.16
|
)
|
(0.38
|
) |
0.84
|
||||||
State income tax expense
|
|
(1.40
|
)
|
0.12
|
0.40
|
|||||||
Change in valuation allowance
|
|
(5.75
|
)
|
(3.26
|
) |
14.95
|
||||||
Benefit for income taxes
|
|
0.0
|
%
|
0.00
|
% |
1.07
|
% | |||||
|
December 31,
|
|||||||
|
2019
|
|
2018
|
|
||||
Deferred tax assets:
|
|
|
||||||
Net operating loss carryforwards
|
$ |
49,668,232
|
$ |
43,872,566
|
||||
Accrued employee benefits
|
589,667
|
441,780
|
||||||
Research and development credit
|
9,321,214
|
9,321,214
|
||||||
Stock compensation
|
12,965,250
|
10,530,859
|
||||||
Federal AMT credit
|
264,609
|
529,218
|
||||||
Deferred rent
|
—
|
712,314
|
||||||
Capital lease
|
4,973,618
|
—
|
||||||
Unrealized comprehensive loss
|
—
|
146,531
|
||||||
Depreciation
|
—
|
1,082
|
||||||
|
|
|
|
|
|
|
|
|
Deferred tax liabilities:
|
|
|
||||||
Right of use asset—capital lease
|
(3,922,583
|
) |
—
|
|||||
Unrealized gains on investment
|
(27,577
|
) |
—
|
|||||
Depreciation
|
(230,760
|
) |
—
|
|||||
Net deferred tax asset before valuation allowance
|
73,601,670
|
65,555,564
|
||||||
Valuation allowance
|
(73,337,061
|
) |
(65,026,346
|
) | ||||
Net deferred tax asset
|
$ |
264,609
|
$ |
529,218
|
||||
|
December 31,
|
|||||||
|
2019
|
|
2018
|
|
||||
Balance at January 1,
|
$
|
1,738,815
|
|
$ |
1,738,815
|
|||
Current Year Uncertain Tax Positions:
|
|
|
|
|
||||
Gross
Change
|
|
—
|
|
—
|
||||
Balance at December 31,
|
$
|
1,738,815
|
|
$ |
1,738,815
|
|||
2019 Quarter Ended
|
December 31,
|
|
September 30,
|
|
June 30,
|
|
March 31,
|
|
||||||||
Net loss
|
(40,582,851
|
) |
(34,862,399
|
) |
(37,441,164
|
) |
(34,835,764
|
) | ||||||||
Basic and diluted net loss per share
|
$ |
(0.74
|
) | $ |
(0.63
|
) | $ |
(0.68
|
) | $ |
(0.63
|
) |
2018 Quarter Ended
|
December 31,
|
|
September 30,
|
|
June 30,
|
|
March 31,
|
|
||||||||
Net loss
|
(40,748,036
|
) |
(41,522,914
|
) |
(37,376,383
|
) |
(35,480,078
|
) | ||||||||
Basic and diluted net loss per share
|
$ |
(0.75
|
) | $ |
(0.76
|
) | $ |
(0.68
|
) | $ |
(0.65
|
) |
Exhibit 4.2
DESCRIPTION OF THE REGISTRANTS SECURITIES
REGISTERED PURSUANT TO SECTION 12 OF
THE SECURITIES EXCHANGE ACT OF 1934, AS AMENDED
Intra-Cellular Therapies, Inc. (the Company or we) has one class of securities registered under Section 12 of the Securities Exchange Act of 1934, as amended: our common stock, par value $0.0001 per share.
DESCRIPTION OF COMMON STOCK
We are authorized to issue 100,000,000 shares of common stock, par value $0.0001 per share, and 5,000,000 shares of preferred stock, par value $0.0001 per share.
The following summary of certain provisions of our common stock does not purport to be complete. You should refer to our restated certificate of incorporation and our restated bylaws, both of which are incorporated by reference as exhibits to the Companys Annual Report on Form 10-K of which this Exhibit is a part. The summary below is also qualified by provisions of applicable law.
General
Holders of our common stock are entitled to one vote for each share held on all matters submitted to a vote of stockholders and do not have cumulative voting rights. An election of directors by our stockholders shall be determined by a plurality of the votes cast by the stockholders entitled to vote on the election. Holders of common stock are entitled to receive proportionately any dividends as may be declared by our board of directors, subject to any preferential dividend rights of any series of preferred stock that we may designate and issue in the future.
In the event of our liquidation or dissolution, the holders of common stock are entitled to receive proportionately our net assets available for distribution to stockholders after the payment of all debts and other liabilities and subject to the prior rights of any outstanding preferred stock. Holders of common stock have no preemptive, subscription, redemption or conversion rights. There are no redemption or sinking fund provisions applicable to the common stock. Our outstanding shares of common stock are validly issued, fully paid and nonassessable. The rights, preferences and privileges of holders of common stock are subject to and may be adversely affected by the rights of the holders of shares of any series of preferred stock that we may designate and issue in the future.
Transfer Agent and Registrar
The transfer agent and registrar for our common stock is Computershare Trust Company, N.A., with offices at 250 Royall Street, Canton, Massachusetts 02021.
Stock Exchange Listing
Our common stock is listed for quotation on The Nasdaq Global Select Market under the symbol ITCI.
CERTAIN PROVISIONS OF DELAWARE LAW AND OF THE COMPANYS
CERTIFICATE OF INCORPORATION AND BYLAWS
Anti-Takeover Provisions
The provisions of Delaware law and our restated certificate of incorporation and restated bylaws could discourage or make it more difficult to accomplish a proxy contest or other change in our management or the acquisition of control by a holder of a substantial amount of our voting stock. It is possible that these provisions could make it more difficult to accomplish, or could deter, transactions that stockholders may otherwise consider to be in their best interests or in our best interests. These provisions are intended to enhance the likelihood of continuity and stability in the composition of our board of directors and in the policies formulated by the board of directors and to discourage certain types of transactions that may involve an actual or threatened change of our control. These provisions are designed to reduce our vulnerability to an unsolicited acquisition proposal and to discourage certain tactics that may be used in proxy fights. Such provisions also may have the effect of preventing changes in our management.
Delaware Statutory Business Combinations Provision
We are subject to the anti-takeover provisions of Section 203 of the Delaware General Corporation Law. Section 203 prohibits a publicly-held Delaware corporation from engaging in a business combination with an interested stockholder for a period of three years after the date of the transaction in which the person became an interested stockholder, unless the business combination is, or the transaction in which the person became an interested stockholder was, approved in a prescribed manner or another prescribed exception applies. For purposes of Section 203, a business combination is defined broadly to include a merger, asset sale or other transaction resulting in a financial benefit to the interested stockholder, and, subject to certain exceptions, an interested stockholder is a person who, together with his or her affiliates and associates, owns, or within three years prior, did own, 15% or more of the corporations voting stock.
Classified Board of Directors; Removal of Directors for Cause
Pursuant to our restated certificate of incorporation and restated bylaws, our board of directors is divided into three classes, with the term of office of the first class to expire at the first annual meeting of stockholders following the initial classification of directors, the term of office of the second class to expire at the second annual meeting of stockholders following the initial classification of directors, and the term of office of the third class to expire at the third annual meeting of stockholders following the initial classification of directors. At each annual meeting of stockholders, directors elected to succeed those directors whose terms expire, other than directors elected by the holders of any series of preferred stock under specified circumstances, will be elected for a three-year term of office. All directors elected to our classified board of directors will serve until the election and qualification of their respective successors or their earlier resignation or removal. Members of the board of directors may only be removed for cause and only by the affirmative vote of at least 80% of our outstanding voting stock. These provisions are likely to increase the time required for stockholders to change the composition of the board of directors. For example, at least two annual meetings will be necessary for stockholders to effect a change in a majority of the members of the board of directors.
Advance Notice Provisions for Stockholder Proposals and Stockholder Nominations of Directors
Our restated bylaws provide that, for nominations to the board of directors or for other business to be properly brought by a stockholder before a meeting of stockholders, the stockholder must first have given timely notice of the proposal in writing to our Secretary. For an annual meeting, a stockholders notice generally must be delivered not less than 90 days nor more than 120 days prior to the first anniversary of the previous years annual meeting date. For a special meeting, the notice must generally be delivered not earlier than the 90th day prior to the meeting and not later than the later of (1) the 60th day prior to the meeting or (2) the 10th day following the day on which public announcement of the meeting is first made. Detailed requirements as to the form of the notice and information required in the notice are specified in the restated bylaws. If it is determined that business was not properly brought before a meeting in accordance with our bylaw provisions, such business will not be conducted at the meeting.
Special Meetings of Stockholders
Special meetings of the stockholders may be called only by our board of directors pursuant to a resolution adopted by a majority of the total number of directors.
No Stockholder Action by Written Consent
Any action to be effected by our stockholders must be effected at a duly called annual or special meeting of the stockholders.
Super Majority Stockholder Vote Required for Certain Actions
The Delaware General Corporation Law provides generally that the affirmative vote of a majority of the shares entitled to vote on any matter is required to amend a corporations certificate of incorporation or bylaws, unless the corporations certificate of incorporation or bylaws, as the case may be, require a greater percentage. Our restated certificate of incorporation requires the affirmative vote of the holders of at least 80% of our outstanding voting stock to amend or repeal any of the provisions discussed in this section of this Exhibit. This 80% stockholder vote would be in addition to any separate class vote that might in the future be required pursuant to the terms of any preferred stock that might then be outstanding. An 80% vote is also required for any amendment to, or repeal of, our restated bylaws by the stockholders. Our restated bylaws may be amended or repealed by a simple majority vote of the board of directors.
Exhibit 10.28
INTRA-CELLULAR THERAPIES, INC.
NON-EMPLOYEE DIRECTOR COMPENSATION POLICY
(adopted June 30, 2014; amended March 30, 2016, December 14, 2017, June 18, 2018 and February 26, 2020)
The Board of Directors of Intra-Cellular Therapies, Inc. (the Company) has approved the following Non-Employee Director Compensation Policy (this Policy), which establishes compensation to be paid to non-employee directors of the Company, to provide an inducement to obtain and retain the services of qualified persons to serve as members of the Companys Board of Directors.
Applicable Persons
This Policy shall apply to each director of the Company who is not an employee of, or compensated consultant to, the Company or any Affiliate (each, an Outside Director). Affiliate shall mean an entity which is a direct or indirect parent or subsidiary of the Company, as determined pursuant to Section 424 of the Internal Revenue Code of 1986, as amended.
Compensation
A. |
Equity Grants |
1. |
Annual Stock Option Grants |
Each Outside Director shall be granted, automatically and without any action on the part of the Board of Directors, under the Companys 2013 Equity Incentive Plan or any successor plan (the Equity Plan), (i) a non-qualified stock option (the Annual Option Grant) to purchase 20,000 shares of the Companys common stock, par value $0.0001 per share (Common Stock), or (ii) at such Outside Directors written election at least 30 days prior to the date of grant, the number of restricted stock units of the Company (the Annual Restricted Stock Unit Grant, and together with the Annual Option Grant, the Annual Equity Grant) having equivalent value (using the applicable Black Scholes valuation methodology) to the Annual Option Grant, each year on the date of the Companys annual meeting of stockholders; provided, however, that if there has been no annual meeting of stockholders held by the first business day of the third fiscal quarter, each Outside Director shall be granted, automatically and without any action on the part of the Board of Directors such Annual Equity Grant on the first business day of the third fiscal quarter of such year.
The foregoing Annual Equity Grants shall commence with the 2018 Annual Meeting of Stockholders.
2. |
Initial Stock Option Grants for Newly Appointed or Elected Directors |
Each new Outside Director shall be granted, automatically and without any action on the part of the Board of Directors, under the Equity Plan, a non-qualified stock option to purchase 20,000 shares of Common Stock on the date that the Outside Director is first appointed or elected to the Board of Directors.
3. |
Terms of Equity Grants |
All Annual Option Grants and initial stock option grants to Outside Directors under this Policy shall vest in one year on the anniversary of the date of grant, subject to the Outside Directors continued service on the Board of Directors, shall have a term of ten years, and shall have an exercise price equal to the fair market value of the Companys Common Stock as determined under the Equity Plan on the date of grant. The stock options shall become fully vested immediately prior to a Change of Control (as defined below).
All Annual Restricted Stock Unit Grants to Outside Directors under this Policy shall vest in one year on the anniversary of the date of grant, subject to the Outside Directors continued service on the Board of Directors. Annual Restricted Stock Unit Grants shall become fully vested immediately prior to a Change of Control (as defined below).
Change of Control means the occurrence of any of the following events: (i) any Person (as such term is used in Sections 13(d) and 14(d) of the Securities Exchange Act of 1934, as amended (the Exchange Act)) becomes the Beneficial Owner (as defined in Rule 13d-3 under the Exchange Act), directly or indirectly, of securities of the Company representing 50% or more of the total voting power represented by the Companys then outstanding voting securities (excluding for this purpose any such voting securities held by the Company or its affiliates or by any employee benefit plan of the Company) pursuant to a transaction or a series of related transactions; or (ii)(a) a merger or consolidation of the Company whether or not approved by the Board of Directors, other than a merger or consolidation which would result in the voting securities of the Company outstanding immediately prior thereto continuing to represent (either by remaining outstanding or by being converted into voting securities of the surviving entity or the parent of such corporation) more than 50% of the total voting power represented by the voting securities of the Company or such surviving entity or parent of such corporation, as the case may be, outstanding immediately after such merger or consolidation; or (b) the sale or disposition by the Company of all or substantially all of the Companys assets in a transaction requiring stockholder approval.
B. |
Cash Fees or Fully-Vested Stock or Fully Vested Stock Options in Lieu of Cash Fees |
1. |
Annual Cash Fees |
The following annual cash fees shall be paid to the Outside Directors serving on the Board of Directors and the Audit Committee, Compensation Committee and Nominating and Governance Committee, as applicable.
Board of Directors or Committee of Board of Directors |
Annual Retainer
Amount for Chair (or Lead Independent Director, as applicable) |
Annual Retainer
Amount for Other Members |
||||||
Board of Directors |
$ | 65,000 | $ | 45,000 | ||||
|
|
|
|
|||||
Audit Committee |
$ | 20,000 | $ | 10,000 | ||||
|
|
|
|
|||||
Compensation Committee |
$ | 15,000 | $ | 8,000 | ||||
|
|
|
|
|||||
Nominating and Governance Committee |
$ | 10,000 | $ | 5,000 | ||||
|
|
|
|
2. |
Payment Terms for All Cash Fees |
Cash fees payable to Outside Directors shall be paid quarterly in arrears as of the last business day of each fiscal quarter.
Following an Outside Directors first election or appointment to the Board of Directors, such Outside Director shall receive his or her cash compensation pro-rated during the first fiscal quarter in which he or she was initially appointed or elected for the number of days during which he or she provides service. If an Outside Director dies, resigns or is removed during any quarter, he or she shall be entitled to a cash payment on a pro-rated basis through his or her last day of service that shall be paid on the last business day of the fiscal quarter.
3. |
Election to Receive Fully-Vested Shares of Common Stock or Fully Vested Stock Options in Lieu of Annual Cash Fees |
In lieu of all or a portion of the annual cash fees, an Outside Director may elect by prior written notice to the Company to receive fully-vested shares of Common Stock (a Stock Award) or fully-vested non-qualified stock options under the Equity Plan on the last business day of each fiscal quarter for the equivalent value of the cash fees due. Such grant shall be made automatically and without any action on the part of the Board of Directors under the Equity Plan. The number of shares with respect to a Stock Award shall be calculated by dividing the cash fees as determined above by the fair market value of the Common Stock as determined under the Equity Plan on the last business day of each fiscal quarter. Should the Outside Director elect to receive stock options, the number of shares underlying a stock option shall be calculated by determining the number of shares that is equivalent to the cash fees due as determined above using the Black Scholes value applicable to the Companys stock option grants calculated on the last business day of each fiscal quarter. Each stock option grant shall have a term of ten years, unless the Director ceases serving as a member of the Board of Directors and shall have an exercise price equal to the fair market value of the Companys Common Stock as determined under the Equity Plan on the date of grant.
Expenses
Upon presentation of documentation of such expenses reasonably satisfactory to the Company, each Outside Director shall be reimbursed for his or her reasonable out-of-pocket business expenses incurred in connection with attending meetings of the Board of Directors and Committees thereof or in connection with other business related to the Board of Directors. Each Outside Director shall abide by the Companys travel and other expense policies applicable to Company personnel.
Amendments
The Compensation Committee or the Board of Directors shall review this Policy from time to time to assess whether any amendments in the type and amount of compensation provided herein should be adjusted in order to fulfill the objectives of this Policy.
Exhibit 10.32
INTRA-CELLULAR THERAPIES, INC.
2019 INDUCEMENT AWARD PLAN
ADOPTED BY THE COMPENSATION COMMITTEE: DECEMBER 16, 2019
EFFECTIVE DATE: DECEMBER 16, 2019
1. GENERAL.
(a) Eligible Award Recipients. Awards may only be granted to Employees who satisfy the standards for inducement grants under Rule 5635(c)(4) of the Nasdaq Listing Rules. A person who previously served as an Employee or Director will not be eligible to receive Awards, other than following a bona fide period of non-employment.
(b) Available Awards. The Plan provides for the grant of the following types of Awards: (i) Nonstatutory Stock Options, (ii) Stock Appreciation Rights, (iii) Restricted Stock Awards, (iv) Restricted Stock Unit Awards, and (v) Other Stock Awards.
(c) Purpose. The Plan, through the granting of Stock Awards, is intended to help the Company secure and retain the services of eligible award recipients, provide an inducement material for such persons to enter into employment with the Company or an Affiliate within the meaning of Rule 5635(c)(4) of the Nasdaq Listing Rules, provide incentives for such persons to exert maximum efforts for the success of the Company and any Affiliate and provide a means by which the eligible recipients may benefit from increases in value of the Common Stock.
2. ADMINISTRATION.
(a) Administration by Board. The Board will administer the Plan. The Board may delegate administration of the Plan to a Committee or Committees, as provided in Section 2(c). However, notwithstanding the foregoing or anything in the Plan to the contrary, the grant of Awards will be approved by the Companys independent compensation committee or a majority of the Companys independent directors (as defined in Rule 5605(a)(2) of the Nasdaq Listing Rules) in order to comply with the exemption from the stockholder approval requirement for inducement grants provided under Rule 5635(c)(4) of the Nasdaq Listing Rules.
(b) Powers of Board. The Board will have the power, subject to, and within the limitations of, the express terms of the Plan:
(i) To determine (A) who will be granted Awards; (B) when and how each Award will be granted; (C) what type of Award will be granted; (D) the terms of each Award, which need not be identical, including when the Participant will be permitted to exercise or otherwise receive Common Stock under the Award; (E) the number of shares of Common Stock subject to an Award; and (F) the Fair Market Value applicable to a Stock Award.
1
(ii) To construe and interpret the Plan and Awards granted under it, and to establish, amend and revoke rules and regulations for administration of the Plan and Awards. The Board, in the exercise of these powers, may correct any defect, omission or inconsistency in the Plan or in any Award Agreement, in a manner and to the extent it determines necessary or expedient to make the Plan or Award fully effective.
(iii) To settle all controversies regarding the Plan and Stock Awards granted under it.
(iv) To accelerate, in whole or in part, the time at which a Stock Award may be exercised or vest, or at which shares of Common Stock may be issued.
(v) To suspend or terminate the Plan at any time. Except as otherwise provided in the Plan or an Award Agreement, suspension or termination of the Plan will not materially impair a Participants rights under his or her then-outstanding Award without the Participants written consent except as provided in Section 2(b)(viii).
(vi) To amend the Plan in any respect the Board determines necessary or advisable, including, without limitation, by adopting amendments relating to nonqualified deferred compensation under Section 409A of the Code, and/or to make the Plan or Awards granted under the Plan exempt from or compliant with the requirements for nonqualified deferred compensation under Section 409A of the Code, subject to the limitations, if any, of applicable law. If required by applicable law or listing requirements, and except as provided in Section 9(a) relating to Capitalization Adjustments, the Company will seek stockholder approval of any amendment of the Plan. Except as provided in Section 9(a) relating to Capitalization Adjustments, the Board may not without stockholder approval reduce the exercise price of an Option or Stock Appreciation Right or cancel any outstanding Option or Stock Appreciation Right in exchange for a replacement option or stock appreciation right having a lower exercise or strike price, or any other Stock Award or for cash. In addition, the Board shall not take any other action that is considered a direct or indirect repricing for purposes of the stockholder approval rules of the applicable securities exchange or inter-dealer quotation system on which the Common Stock is listed, including any action that is treated as a repricing under generally accepted accounting principles. Except as provided in the Plan (including Section 2(b)(viii)) or an Award Agreement, no amendment of the Plan will materially impair a Participants rights under an outstanding Award without the Participants written consent.
(vii) To submit any amendment to the Plan for stockholder approval, including, without limitation, amendments to the Plan intended to satisfy the requirements of Rule 16b-3.
(viii) To approve forms of Award Agreements for use under the Plan and to amend the terms of any one or more Awards, including, without limitation, amendments to provide terms more favorable to the Participant than previously provided in the Award Agreement, subject to any applicable law or listing requirements and any specified limits in the Plan that are not subject to Board discretion; provided, however, that a Participants rights under any Award will not be impaired by any such amendment unless (A) the Company requests the affected Participants consent, and (B) the Participant consents in writing. Notwithstanding the
2
foregoing, (1) a Participants rights will not be deemed to have been impaired by any such amendment if the Board, in its sole discretion, determines that the amendment, taken as a whole, does not materially impair the Participants rights; and (2) subject to the limitations of applicable law or listing requirements, if any, the Board may amend the terms of any one or more Stock Awards without the affected Participants consent: (A) to clarify the manner of exemption from, or to bring the Award into compliance with, Section 409A of the Code; or (B) to comply with other applicable laws or listing requirements.
(ix) Generally, to exercise the powers and to perform the acts the Board determines necessary or expedient to promote the best interests of the Company and that are not in conflict with the terms of the Plan or Awards.
(x) To adopt any procedures and sub-plans as are necessary or appropriate to permit participation in the Plan by Employees who are foreign nationals or employed outside the United States; provided, however, that Board approval will not be necessary for immaterial modifications to the Plan or any Award Agreement that are required for compliance with the laws of the relevant foreign jurisdiction.
(c) Delegation to a Committee.
(i) General. The Board may delegate some or all of the administration of the Plan to a Committee or Committees. If administration of the Plan is delegated to a Committee, the Committee will have, in connection with the administration of the Plan, the powers theretofore possessed by the Board that have been delegated to the Committee, including the power to delegate to a subcommittee of the Committee any of the administrative powers the Committee is authorized to exercise and references in this Plan to the Board will thereafter be to the Committee or subcommittee, as applicable. Any delegation of administrative powers will be reflected in resolutions, not inconsistent with the terms of the Plan, that the Board or the Committee adopts from time to time. The Committee may, at any time, abolish the subcommittee and revest in the Committee any powers delegated to the subcommittee. The Board may retain the authority to concurrently administer the Plan with the Committee and may, at any time, revest in the Board some or all of the powers previously delegated.
(ii) Rule 16b-3 Compliance. The Committee may consist solely of two or more Non-Employee Directors in accordance with Rule 16b-3.
(d) Effect of the Boards Decision. All determinations, interpretations and constructions made by the Board in good faith will not be subject to review by any person and will be final, binding and conclusive on all persons.
(e) Dividends and Dividend Equivalents. Dividends or dividend equivalents may be paid or credited, as applicable, with respect to any shares of Common Stock subject to an Award, as determined by the Board and contained in the applicable Award Agreement; provided, however, that (i) no dividends or dividend equivalents may be paid with respect to any such shares before the date such shares have vested under the terms of such Award Agreement, (ii) any dividends or dividend equivalents that are credited with respect to any such shares will be
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subject to all of the terms and conditions applicable to such shares under the terms of such Award Agreement (including, but not limited to, any vesting conditions), and (iii) any dividends or dividend equivalents that are credited with respect to any such shares will be forfeited to the Company on the date, if any, such shares are forfeited to or repurchased by the Company due to a failure to meet any vesting conditions under the terms of such Award Agreement.
3. SHARES SUBJECT TO THE PLAN.
(a) Share Reserve. Subject to Section 9(a) relating to Capitalization Adjustments, the aggregate number of shares of Common Stock that may be issued pursuant to Stock Awards will not exceed 1,000,000 shares (the Share Reserve).
(b) Reversion of Shares to the Share Reserve.
(i) Shares Available for Subsequent Issuance. The following shares of Common Stock will become available again for issuance under the Plan: (A) any shares subject to a Stock Award that are not issued because such Stock Award or any portion thereof expires or otherwise terminates without all of the shares covered by such Stock Award having been issued; (B) any shares subject to a Stock Award that are not issued because such Stock Award or any portion thereof is settled in cash; and (C) any shares issued pursuant to a Stock Award that are forfeited back to or repurchased by the Company because of the failure to meet a contingency or condition required for the vesting of such shares.
(ii) Shares Not Available for Subsequent Issuance. Any shares reacquired or withheld (or not issued) by the Company in satisfaction of tax withholding obligations on a Stock Award or as consideration for the exercise or purchase price of a Stock Award will not again become available for issuance under the Plan. Upon exercise of SARs, the gross number of shares exercised shall be deducted from the total number of shares remaining available for issuance under the Plan. Any shares repurchased by the Company on the open market with the proceeds of the exercise or purchase price of a Stock Award will not again become available for issuance under the Plan.
(c) Source of Shares. The stock issuable under the Plan will be shares of authorized but unissued or reacquired Common Stock, including shares repurchased by the Company on the open market or otherwise.
4. ELIGIBILITY.
(a) Eligibility for Awards. Awards may only be granted to persons who are Employees described in Section 1(a), where the Award is an inducement material to the individuals entering into employment with the Company or an Affiliate within the meaning of Rule 5635(c)(4) of the Nasdaq Listing Rules. For clarity, Awards may not be granted to (1) Consultants or Directors, for service in such capacities, or (2) any individual who was previously an Employee or Director, other than following a bona fide period of non-employment. Notwithstanding the foregoing, Awards may not be granted to Employees who are providing Continuous Service only to any parent of the Company, as this term is defined in Rule 405 of
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the Securities Act, unless (i) the stock underlying such Awards is treated as service recipient stock under Section 409A of the Code (for example, because the Awards are granted in connection with a corporate transaction such as a spin off transaction), or (ii) the Company, in consultation with its legal counsel, has determined that such Awards are otherwise exempt from or alternatively comply with the distribution requirements of Section 409A of the Code.
(b) Approval Requirements. All Awards must be granted either by a majority of the Companys independent directors or by the Companys compensation committee comprised of independent directors within the meaning of Rule 5605(a)(2) of the Nasdaq Listing Rules.
5. OPTIONS AND STOCK APPRECIATION RIGHTS.
The Board will determine the form and the terms and conditions of each Option or SAR. All Options will be Nonstatutory Stock Options. The terms of separate Options or SARs need not be identical; provided, however, that each Stock Award Agreement will conform to (through incorporation of provisions of the Plan by reference in the applicable Stock Award Agreement or otherwise) the substance of each of the following terms:
(a) Term. No Option or SAR will be exercisable after the expiration of ten years from the date of its grant or a shorter period specified in the Stock Award Agreement.
(b) Exercise Price. The exercise or strike price of each Option or SAR will be not less than 100% of the Fair Market Value of the Common Stock subject to the Option or SAR on the date the Award is granted. Notwithstanding the foregoing, an Option or SAR may be granted with an exercise or strike price lower than 100% of the Fair Market Value of the Common Stock subject to such Award if the Award is granted pursuant to an assumption of or substitution for another option or stock appreciation right in connection with a Corporate Transaction and in a manner consistent with the provisions of Section 409A of the Code. Each SAR will be denominated in shares of Common Stock equivalents.
(c) Exercise Price for Options. The exercise price of Common Stock acquired upon the exercise of an Option may be paid, to the extent permitted by applicable law and as determined by the Board in its sole discretion, by any combination of the following methods of payment. The Board will have the authority to grant Options that permit any one or more of the following methods of payment (or to restrict the ability to use any particular method or methods) and to grant Options that require the Companys consent to use a particular method of payment. The permitted methods of payment are:
(i) by cash, check, bank draft or money order payable to the Company;
(ii) pursuant to a program developed under Regulation T as promulgated by the Federal Reserve Board that, prior to the issuance of the Common Stock, results in the Companys receipt of cash or check or the receipt of irrevocable instructions to pay the aggregate purchase price to the Company from the sales proceeds;
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(iii) by delivery to the Company (either by actual delivery or attestation) of shares of Common Stock;
(iv) by a net exercise arrangement pursuant to which the Company will reduce the number of shares of Common Stock issuable upon exercise by the largest whole number of shares with a Fair Market Value that does not exceed the aggregate exercise price; provided, however, that the Company will accept cash or other payment from the Participant to the extent of any remaining balance of the aggregate exercise price not satisfied by a reduction in the number of whole shares to be issued. Shares of Common Stock will no longer be subject to an Option and will not be exercisable after a net exercise to the extent that (A) shares issuable upon the exercise are used to pay the exercise price pursuant to the net exercise, (B) shares are delivered to the Participant as a result of the exercise, and (C) shares are withheld to satisfy tax withholding obligations; or
(v) in any other form of legal consideration that the Board determines acceptable and specifies in the applicable Stock Award Agreement.
(d) Exercise and Payment of a SAR. To exercise any outstanding SAR, the Participant must provide written notice of exercise to the Company in compliance with the terms of the Stock Appreciation Right Agreement evidencing the SAR. The appreciation distribution payable on the exercise of a SAR will be not greater than an amount equal to the excess of (A) the aggregate Fair Market Value (on the date of the exercise of the SAR) of a number of shares of Common Stock equal to the number of Common Stock equivalents in which the Participant is vested under the SAR, and with respect to which the Participant is exercising the SAR on the applicable exercise date, over (B) the aggregate strike price of the number of Common Stock equivalents with respect to which the Participant is exercising the SAR on such date. The appreciation distribution may be paid in Common Stock, or in any other form of consideration, as the Board determines and describes in the applicable Award Agreement evidencing such SAR.
(e) Transferability of Options and SARs. The Board may, in its sole discretion, impose limitations on the transferability of Options and SARs as the Board determines. In the absence of a determination by the Board to the contrary, the following restrictions on the transferability of Options and SARs will apply:
(i) Restrictions on Transfer. An Option or SAR will not be transferable except by will or by the laws of descent and distribution (and pursuant to Sections 5(e)(ii) and 5(e)(iii)), and will be exercisable during the lifetime of the Participant only by the Participant. The Board may permit a transfer of the Option or SAR in a manner that is permissible under applicable tax and securities laws. Except as explicitly provided in the Plan, neither an Option nor a SAR may be transferred for consideration.
(ii) Domestic Relations Orders. Subject to the approval of the Board or a duly authorized Officer, an Option or SAR may be transferred pursuant to the terms of a domestic relations order, official marital settlement agreement or other divorce or separation instrument.
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(iii) Beneficiary Designation. Subject to the approval of the Board or a duly authorized Officer, a Participant may, by delivering written notice to the Company, in a form approved by the Company (or its designated broker), designate a third party who, on the Participants death, will thereafter be entitled to exercise the Option or SAR and receive the Common Stock or other consideration resulting from the exercise. In the absence of a designation, the executor or administrator of the Participants estate will be entitled to exercise the Option or SAR and receive the Common Stock or other consideration resulting from the exercise. However, the Company may prohibit designation of a beneficiary at any time, including due to any conclusion by the Company that a designation would be inconsistent with applicable law.
(f) Vesting Generally. The total number of shares of Common Stock subject to an Option or SAR may vest and therefore become exercisable in periodic installments that may or may not be equal. The Board will determine whether the Option or SAR is subject to other terms and conditions on the time or times when the Award may or may not be exercised, which may be based on the satisfaction of performance goals or other criteria. The vesting terms of individual Options or SARs may vary. The provisions of this Section 5(f) are subject to any term in an Option or SAR specifying the minimum number of shares of Common Stock as to which the Option or SAR may be exercised.
(g) Termination of Continuous Service. Except as otherwise provided in the applicable Award Agreement or other agreement between the Participant and the Company, if a Participants Continuous Service terminates (other than for Cause and other than upon the Participants death or Disability), the Participant may exercise his or her Option or SAR (to the extent that the Participant was entitled to exercise such Award as of the date of termination of Continuous Service) within the period of time ending on the earlier of (i) the date three months following the termination of the Participants Continuous Service (or such longer or shorter period specified in the applicable Award Agreement, which period will not be less than 30 days if necessary to comply with applicable law unless the Participants termination is for Cause); and (ii) the expiration of the term of the Option or SAR as set forth in the applicable Award Agreement. If, after termination of Continuous Service, the Participant does not exercise his or her Option or SAR within the designated time frame, the Option or SAR will terminate.
(h) Extension of Termination Date. Except as otherwise provided in the applicable Award Agreement or other agreement between the Participant and the Company or an Affiliate, if the exercise of an Option or SAR following the termination of the Participants Continuous Service (other than for Cause and other than upon the Participants death or Disability) would be prohibited at any time solely because the issuance of shares of Common Stock would violate the registration requirements under the Securities Act, then the Option or SAR will terminate on the earlier of (i) the expiration of a total period of time (which need not be consecutive) equal to the applicable post termination exercise period after the termination of the Participants Continuous Service during which the exercise of the Option or SAR would not be in violation of such registration requirements, and (ii) the expiration of the term of the Option or SAR as set forth in the applicable Award Agreement. In addition, unless otherwise provided in a Participants Award Agreement, if the sale of any Common Stock received upon exercise of an Option or
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SAR following the termination of the Participants Continuous Service (other than for Cause) would violate the Companys insider trading policy, then the Option or SAR will terminate on the earlier of (i) the expiration of a period of months (which need not be consecutive) equal to the applicable post-termination exercise period after the termination of the Participants Continuous Service during which the sale of the Common Stock received upon exercise of the Option or SAR would not be in violation of the Companys insider trading policy, or (ii) the expiration of the term of the Option or SAR as set forth in the applicable Stock Award Agreement.
(i) Disability of Participant. Except as otherwise provided in the applicable Award Agreement or other agreement between the Participant and the Company or an Affiliate, if a Participants Continuous Service terminates as a result of the Participants Disability, the Participant may exercise his or her Option or SAR (to the extent that the Participant was entitled to exercise the Option or SAR as of the date of termination of Continuous Service), but only within the period of time ending on the earlier of (i) the date 12 months following the termination of the Participants Continuous Service (or such longer or shorter period specified in the Stock Award Agreement, which period will not be less than six months if necessary to comply with applicable law), and (ii) the expiration of the term of the Option or SAR as set forth in the Stock Award Agreement. If, after termination of Continuous Service, the Participant does not exercise his or her Option or SAR within the applicable time frame, the Option or SAR (as applicable) will terminate.
(j) Death of Participant. Except as otherwise provided in the applicable Award Agreement or other agreement between the Participant and the Company, if (i) a Participants Continuous Service terminates as a result of the Participants death, or (ii) the Participant dies within the period, if any, specified in the Award Agreement for exercisability after the termination of the Participants Continuous Service (for a reason other than death), then the Option or SAR may be exercised (to the extent the Participant was entitled to exercise the Option or SAR as of the date of death) by the Participants estate, by a person who acquired the right to exercise the Option or SAR by bequest or inheritance, or by a person designated to exercise the Option or SAR upon the Participants death, but only within the period ending on the earlier of (A) the date 18 months following the date of the Participants death (or such longer or shorter period specified in the Award Agreement, which period will not be less than six months if necessary to comply with applicable laws), and (B) the expiration of the term of the Option or SAR as set forth in the Award Agreement. If, after the Participants death, the Option or SAR is not exercised within the applicable time frame, the Option or SAR will terminate.
(k) Termination for Cause. Except as otherwise provided in the applicable Award Agreement or other agreement or other individual written agreement between the Participant and the Company or any Affiliate, if a Participants Continuous Service is terminated for Cause, the Option or SAR will terminate immediately upon the Participants notification of a termination of Continuous Service for Cause and the Participant will be prohibited from exercising the Option or SAR from and after the time of the Participants notification of a termination of Continuous Service for Cause.
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(l) Non-Exempt Employees. If an Option or SAR is granted to an Employee who is a non-exempt employee for purposes of the Fair Labor Standards Act of 1938, as amended, the Option or SAR will not be first exercisable for any shares of Common Stock until at least six months following the date of grant (although the Award may vest prior to that date). Consistent with the provisions of the Worker Economic Opportunity Act, (i) if a non-exempt Employee dies or suffers a Disability; (ii) upon a Corporate Transaction in which the Option or SAR is not assumed, continued, or substituted; or (iii) upon the Participants retirement (as that term may be defined in the applicable Award Agreement in another agreement between the Participant and the Company or an Affiliate, or, if no definition exists, in accordance with the Companys then-current employment policies and guidelines), the vested portion of any Option and SAR held by the Employee may be exercised earlier than six months following the date of grant. This Section 5(l) is intended to operate so that any income derived by a non-exempt employee in connection with the exercise, vesting or issuance of any shares under an Option or SAR will be exempt from the employees regular rate of pay. To the extent permitted and/or required for compliance with the Worker Economic Opportunity Act, to ensure that any income derived by a non-exempt employee in connection with the exercise, vesting or issuance of any shares under any other Stock Award will be exempt from the employees regular rate of pay, this Section 5(l) will apply to all Stock Awards and is incorporated by reference into the applicable Stock Award Agreements.
6. STOCK AWARDS OTHER THAN OPTIONS AND SARS.
(a) Restricted Stock Awards. The Board will determine the form and terms and conditions of each Restricted Stock Agreement. To the extent consistent with the Companys bylaws, at the Boards election, shares of Common Stock may be (i) held in book entry form subject to the Companys instructions until any restrictions relating to the Restricted Stock Award lapse; or (ii) evidenced by a certificate, which certificate will be held in the form and manner the Board determines. The terms and conditions of Restricted Stock Agreements may change from time to time, and the terms and conditions of separate Restricted Stock Agreements need not be identical. Each Restricted Stock Agreement will conform to (through incorporation of the provisions hereof by reference in the agreement or otherwise) the substance of each of the following terms:
(i) Consideration. A Restricted Stock Award may be granted in consideration for (A) cash, check, bank draft or money order payable to the Company; or (B) any other form of legal consideration (including future services) that may be acceptable to the Board, in its sole discretion, and permissible under applicable law.
(ii) Vesting. Shares of Common Stock granted under the Restricted Stock Award Agreement may be subject to forfeiture to the Company in accordance with a vesting schedule determined by the Board.
(iii) Termination of Participants Continuous Service. If a Participants Continuous Service terminates, the Company may receive, through a forfeiture condition or a repurchase right, any or all of the shares of Common Stock held by the Participant that have not vested as of the date of termination of Continuous Service under the terms of the Restricted Stock Award Agreement.
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(iv) Transferability. Shares of Common Stock granted to a Participant under a Restricted Stock Award Agreement will be transferable by the Participant only upon the terms and conditions as the Board will determine, in its sole discretion, and described in the Restricted Stock Award Agreement, so long as the shares of Common Stock granted under the Restricted Stock Award Agreement remain subject to the terms of the Restricted Stock Award Agreement.
(b) Restricted Stock Unit Awards. Each Restricted Stock Unit Award Agreement will be in such form and will contain such terms and conditions as the Board will deem appropriate. The terms and conditions of Restricted Stock Unit Award Agreements may change from time to time, and the terms and conditions of separate Restricted Stock Unit Award Agreements need not be identical. Each Restricted Stock Unit Award Agreement will conform to (through incorporation of the provisions hereof by reference in the Agreement or otherwise) the substance of each of the following provisions:
(i) Consideration. At the time of grant of a Restricted Stock Unit Award, the Board will determine the consideration, if any, to be paid by the Participant upon delivery of each share of Common Stock subject to the Restricted Stock Unit Award. The consideration to be paid (if any) by the Participant for each share of Common Stock subject to a Restricted Stock Unit Award may be paid in any form of legal consideration that may be acceptable to the Board, in its sole discretion, and permissible under applicable law.
(ii) Vesting. At the time of the grant of a Restricted Stock Unit Award, the Board may impose such restrictions on or conditions to the vesting of the Restricted Stock Unit Award as it, in its sole discretion, deems appropriate.
(iii) Payment. A Restricted Stock Unit Award may be settled by the delivery of shares of Common Stock or in any other form of consideration, as determined by the Board and contained in the Restricted Stock Unit Award Agreement.
(iv) Additional Restrictions. At the time of the grant of a Restricted Stock Unit Award, the Board, as it deems appropriate, may impose such restrictions or conditions that delay the delivery of the shares of Common Stock subject to a Restricted Stock Unit Award to a time after the vesting of such Restricted Stock Unit Award.
(v) Termination of Participants Continuous Service. Except as otherwise provided in the applicable Restricted Stock Unit Award Agreement, such portion of the Restricted Stock Unit Award that has not vested will be forfeited upon the Participants termination of Continuous Service.
(c) Other Stock Awards. Other forms of Stock Awards valued in whole or in part by reference to, or otherwise based on, the Common Stock may be granted either alone or in addition to other Stock Awards granted under Section 5 and this Section 6. Subject to the terms of the Plan (including, but not limited to, Section 2(e)), the Board will have sole and complete authority to determine the persons to whom and the time or times at which Other Stock Awards will be granted, the number of shares of Common Stock to be granted pursuant to Other Stock Awards, and all other terms and conditions of Other Stock Awards.
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7. COVENANTS OF THE COMPANY.
(a) Availability of Shares. The Company will keep available at all times the number of shares of Common Stock reasonably required to satisfy then-outstanding Awards.
(b) Securities Law Compliance. The Company will seek to obtain from each regulatory commission or agency having jurisdiction over the Plan the authority as may be required to grant Stock Awards and to issue and sell shares of Common Stock upon exercise of the Stock Awards; provided, however, that this undertaking will not require the Company to register under the Securities Act the Plan, any Stock Award or any Common Stock issued or issuable pursuant to any Stock Award. If, after reasonable efforts and at a reasonable cost, the Company is unable to obtain from any regulatory commission or agency the authority that counsel for the Company determines necessary for the lawful issuance and sale of Common Stock under the Plan, the Company will be relieved from any liability for failure to issue and sell Common Stock upon exercise of Stock Awards unless and until such authority is obtained. A Participant will not be eligible to receive a grant of an Award or be issued shares of Common Stock pursuant to the Award if the grant or issuance would be in violation of any applicable securities law.
(c) No Obligation to Notify or Minimize Taxes. The Company will have no duty or obligation to any Participant to advise the Participant as to the time or manner of exercising any Stock Award. Further, the Company will have no duty or obligation to warn or otherwise advise the Participant of a pending termination or expiration of an Award or a possible period in which the Award may not be exercised. The Company has no duty or obligation to minimize the tax consequences of an Award to any Participant.
8. MISCELLANEOUS.
(a) Use of Proceeds from Sales of Common Stock. Proceeds from the sale of shares of Common Stock pursuant to Stock Awards will constitute general funds of the Company.
(b) Corporate Action Constituting Grant of Stock Awards. Corporate action constituting a grant by the Company of an Award to any Participant will be deemed completed as of the date of such corporate action, unless otherwise determined by the Board, regardless of when the instrument, certificate, or letter evidencing the Award is communicated to, or actually received or accepted by, the Participant. In the event that the corporate records (e.g., Board consents, resolutions or minutes) documenting the corporate action constituting the grant contain terms (e.g., exercise price, vesting schedule or number of shares) that are inconsistent with those in the Award Agreement or related grant documents as a result of a clerical error in the papering of the Award Agreement or related grant documents, the corporate records will control and the Participant will have no legally binding right to the incorrect term in the Award Agreement or related grant documents.
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(c) Stockholder Rights. No Participant will be deemed to be the holder of, or to have any of the rights of a holder with respect to, any shares of Common Stock subject to an Award unless and until (i) the Participant has satisfied all requirements for exercise of, or the issuance of shares of Common Stock under, the Award pursuant to its terms, and (ii) the issuance of the Common Stock subject to the Award has been entered into the books and records of the Company.
(d) No Employment or Other Service Rights. Nothing in the Plan, any Award Agreement or any other instrument executed thereunder or in connection with any Award granted pursuant thereto will confer upon any Participant any right to continue to serve the Company or an Affiliate in the capacity in effect at the time the Award was granted or will affect the right of the Company or an Affiliate to terminate (i) the employment of an Employee with or without notice and with or without cause, (ii) the service of a Consultant pursuant to the terms of such Consultants agreement with the Company or an Affiliate, or (iii) the service of a Director pursuant to the bylaws of the Company or an Affiliate, and any applicable provisions of the corporate law of the state in which the Company or the Affiliate is incorporated, as the case may be.
(e) Change in Time Commitment. If a Participants regular level of time commitment in the performance of his or her services for the Company and any Affiliates is reduced (for example, and without limitation, if the Participant is an Employee of the Company and the Employee has a change in status from a full-time Employee to a part-time Employee or takes an extended leave of absence) after the date of grant of any Award to the Participant, the Board has the right in its sole discretion to (i) make a corresponding reduction in the number of shares subject to any portion of the Award that is scheduled to vest or become payable after the date of the Participants change in time commitment, and (ii) in lieu of or in combination with a reduction, extend the vesting or payment schedule applicable to the Award. In the event of any reduction or modification of the vesting or payment schedule, the Participant will have no right with respect to any portion of the Award that is reduced or modified.
(f) Investment Assurances. The Company may require a Participant, as a condition of exercising or acquiring Common Stock under any Award, (i) to give written assurances satisfactory to the Company as to the Participants knowledge and experience in financial and business matters and/or to employ a purchaser representative reasonably satisfactory to the Company who is knowledgeable and experienced in financial and business matters and that he or she is capable of evaluating, alone or together with the purchaser representative, the merits and risks of exercising the Award; and (ii) to give written assurances satisfactory to the Company stating that the Participant is acquiring the Common Stock subject to the Award for the Participants own account and not with any present intention of selling or otherwise distributing the Common Stock. The foregoing requirements, and any assurances given pursuant to the requirements, will be inoperative if (A) the issuance of the shares upon the exercise or acquisition of Common Stock under the Award has been registered under a then currently effective registration statement under the Securities Act, or (B) as to any particular requirement, counsel for the Company determines that the requirement need not be met in the particular circumstances under then applicable securities laws. The Company may, upon advice of Company counsel, place legends on stock certificates issued under the Plan as Company counsel determines necessary or appropriate to comply with applicable securities laws, including, without limitations, legends restricting the transfer of the Common Stock.
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(g) Withholding Obligations. The Company may, in its sole discretion, satisfy any federal, state or local tax withholding obligation relating to an Award by any of the following means (in addition to the Companys right to withhold from any compensation the Company paid to the Participant) or by a combination of the following means: (i) causing the Participant to tender a cash payment; (ii) withholding shares of Common Stock from the shares of Common Stock issued or otherwise issuable to the Participant in connection with the Award; provided, however, that the Company may not withhold shares of Common Stock with a value exceeding the maximum amount of tax required to be withheld by law (or such other amount as may be necessary to avoid classification of the Award as a liability for financial accounting purposes); (iii) withholding payment from any amounts otherwise payable to the Participant; or (iv) by any other method as may be described in the Award Agreement.
(h) Electronic Delivery. Any reference in the Plan to a written agreement or document will include any agreement or document delivered electronically, filed publicly at www.sec.gov (or any successor website thereto) or posted on the Companys intranet (or other shared electronic medium that the Company controls and to which the Participant has access).
(i) Deferrals. To the extent permitted by applicable law, the Board, in its sole discretion, may determine that the delivery of Common Stock upon the exercise, vesting or settlement of all or a portion of an Award may be deferred and may establish programs and procedures for Participants to make deferral elections. Deferrals by Participants will be made in accordance with Section 409A of the Code. Consistent with Section 409A of the Code, the Board may provide for distributions while a Participant is still an employee or otherwise providing services to the Company. The Board is authorized to make deferrals of Awards and determine when, and in what annual percentages, Participants may receive payments (including lump sum payments) following the Participants termination of Continuous Service, and implement any other terms and conditions consistent with the terms of the Plan and in accordance with applicable law.
(j) Compliance with Section 409A. Unless otherwise expressly provided for in an Award Agreement, the Plan and Award Agreements will be interpreted to the greatest extent possible in a manner that makes the Plan and the Awards granted hereunder exempt from Section 409A of the Code, and, to the extent not so exempt, in compliance with Section 409A of the Code. If the Board determines that any Award granted hereunder is not exempt from and is therefore subject to Section 409A of the Code, the Award Agreement evidencing such Award will incorporate the terms and conditions necessary to avoid the consequences specified in Section 409A(a)(1) of the Code, and to the extent an Award Agreement is silent on terms necessary for compliance, such terms are hereby incorporated by reference into the Award Agreement. Notwithstanding anything to the contrary in this Plan (and unless the Award Agreement specifically provides otherwise), if the shares of Common Stock are publicly traded, and if a Participant holding an Award that constitutes deferred compensation under Section
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409A of the Code is a specified employee for purposes of Section 409A of the Code, no distribution or payment of any amount that is due because of a separation from service (as defined in Section 409A of the Code without regard to alternative definitions thereunder) will be issued or paid before the date that is six months following the date of such Participants separation from service or, if earlier, the date of the Participants death, unless such distribution or payment can be made in a manner that complies with Section 409A of the Code, and any amounts so deferred will be paid in a lump sum on the day after such six month period elapses, with the balance paid thereafter on the original schedule.
(k) Clawback/Recovery. All Awards granted under the Plan will be subject to recoupment in accordance with any clawback policy that the Company is required to adopt pursuant to the listing standards of any national securities exchange or association on which the Companys securities are listed or as is otherwise required by the Dodd-Frank Wall Street Reform and Consumer Protection Act or other applicable law. In addition, the Board may impose such other clawback, recovery or recoupment provisions in an Award Agreement as the Board determines necessary or appropriate, including but not limited to a reacquisition right in respect of previously acquired shares of Common Stock or other cash or property upon the occurrence of Cause. No recovery of compensation under such a clawback policy will be an event giving rise to a right to resign for good reason or constructive termination (or similar term) under any agreement with the Company.
9. ADJUSTMENTS UPON CHANGES IN COMMON STOCK; OTHER CORPORATE EVENTS.
(a) Capitalization Adjustments. In the event of a Capitalization Adjustment, the Board will appropriately and proportionately adjust: (i) the classes and maximum number of securities subject to the Plan under Section 3(a), (ii) the classes and number of securities and price per share of Common Stock subject to outstanding Stock Awards and (iii) performance conditions applicable to outstanding Stock Awards. The Board will make such adjustments, and its determination will be final, binding and conclusive.
(b) Dissolution or Liquidation. Except as otherwise provided in the Stock Award Agreement, in the event of a dissolution or liquidation of the Company, all outstanding Stock Awards (other than Stock Awards consisting of vested and outstanding shares of Common Stock not subject to a forfeiture condition or the Companys right of repurchase) will terminate immediately prior to the completion of the dissolution or liquidation, and the shares of Common Stock subject to the Companys repurchase rights or subject to a forfeiture condition may be repurchased or reacquired by the Company notwithstanding the fact that the Participant is providing Continuous Service; provided, however, that the Board may, in its sole discretion, cause some or all Stock Awards to become fully vested, exercisable and/or no longer subject to repurchase or forfeiture (to the extent such Stock Awards have not previously expired or terminated) before the dissolution or liquidation is completed but contingent on its completion.
(c) Corporate Transaction. The following provisions will apply to Stock Awards in the event of a Corporate Transaction unless otherwise provided in the instrument evidencing the Stock Award, in any other written agreement between the Company or any Affiliate and the Participant, or in any director compensation policy of the Company, or unless otherwise expressly provided by the Board at the time of grant of a Stock Award.
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(i) Stock Awards May Be Assumed. In the event of a Corporate Transaction, any surviving corporation or acquiring corporation (or the surviving or acquiring corporations parent company) may assume or continue any or all outstanding Stock Awards or may substitute similar stock awards for any or all outstanding Stock Awards (including, but not limited to, awards to acquire the same consideration paid to the stockholders of the Company pursuant to the Corporate Transaction), and any reacquisition or repurchase rights held by the Company in respect of Common Stock issued pursuant to any outstanding Stock Awards may be assigned by the Company to the surviving corporation or acquiring corporation (or the surviving or acquiring corporations parent company). For clarity, in the event of a Corporate Transaction, any surviving corporation or acquiring corporation (or the surviving or acquiring corporations parent company) may choose to assume or continue only a portion of an outstanding Stock Award, to substitute a similar stock award for only a portion of an outstanding Stock Award, or to assume or continue, or substitute similar stock awards for, the outstanding Stock Awards held by some, but not all, Participants. The terms of any such assumption, continuation or substitution will be set by the Board.
(ii) Stock Awards Held by Current Participants. In the event of a Corporate Transaction in which the surviving corporation or acquiring corporation (or the surviving or acquiring corporations parent company) does not assume or continue outstanding Stock Awards, or substitute similar stock awards for outstanding Stock Awards, then with respect to any such Stock Awards that have not been assumed, continued or substituted and that are held by Participants whose Continuous Service has not terminated prior to the effective time of the Corporate Transaction (referred to as the Current Participants), the vesting (and exercisability, if applicable) of such Stock Awards will be accelerated in full to a date prior to the effective time of the Corporate Transaction (contingent upon the closing or completion of the Corporate Transaction) as the Board will determine (or, if the Board does not determine such a date, to the date that is five days prior to the effective time of the Corporate Transaction), and such Stock Awards will terminate if not exercised (if applicable) prior to the effective time of the Corporate Transaction in accordance with the exercise procedures determined by the Board, and any reacquisition or repurchase rights held by the Company with respect to such Stock Awards will lapse (contingent upon the closing or completion of the Corporate Transaction).
(iii) Stock Awards Held by Participants other than Current Participants. In the event of a Corporate Transaction in which the surviving corporation or acquiring corporation (or the surviving or acquiring corporations parent company) does not assume or continue outstanding Stock Awards, or substitute similar stock awards for outstanding Stock Awards, then with respect to any such Stock Awards that have not been assumed, continued or substituted and that are held by Participants other than Current Participants, such Stock Awards will terminate if not exercised (if applicable) prior to the effective time of the Corporate Transaction in accordance with the exercise procedures determined by the Board; provided, however, that any reacquisition or repurchase rights held by the Company with respect to such Stock Awards will not terminate and may continue to be exercised notwithstanding the Corporate Transaction.
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(iv) Payment for Stock Awards in Lieu of Exercise. Notwithstanding the foregoing, in the event any outstanding Stock Award held by a Participant will terminate if not exercised prior to the effective time of a Corporate Transaction, the Board may provide, in its sole discretion, that the Participant may not exercise such Stock Award but instead will receive a payment, in such form as may be determined by the Board, equal in value to the excess, if any, of (A) the value of the property the Participant would have received upon the exercise of such Stock Award immediately prior to the effective time of the Corporate Transaction (including, at the discretion of the Board, any unvested portion of such Stock Award), over (B) any exercise price payable by the Participant in connection with such exercise. For clarity, such payment may be zero if the value of such property is equal to or less than the exercise price. Payments under this provision may be delayed to the same extent that payment of consideration to the holders of the Common Stock in connection with the Corporate Transaction is delayed as a result of escrows, earn outs, holdbacks or any other contingencies.
10. TERMINATION OR SUSPENSION OF THE PLAN.
The Board may suspend or terminate the Plan at any time. No Awards may be granted under the Plan while the Plan is suspended or after it is terminated. Termination of the Plan shall not affect any Stock Awards theretofore granted.
11. EFFECTIVE DATE OF PLAN.
The Plan will become effective on the Effective Date.
12. CHOICE OF LAW.
The law of the State of Delaware will govern all questions concerning the construction, validity and interpretation of the Plan, without regard to that states conflict of laws rules.
13. DEFINITIONS. As used in the Plan, the following definitions will apply to the capitalized terms indicated below:
(a) Affiliate means, at the time of determination, any parent or subsidiary of the Company, as these terms are defined in Rule 405 of the Securities Act. The Board will have the authority to determine the time or times at which parent or subsidiary status is determined within the foregoing definition.
(b) Award means a Stock Award.
(c) Award Agreement means a written agreement between the Company and a Participant evidencing the terms and conditions of an Award.
(d) Board means the Board of Directors of the Company.
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(e) Capitalization Adjustment means any change that is made in, or other events that occur with respect to, the Common Stock subject to the Plan or subject to any Stock Award after the Effective Date without the receipt of consideration by the Company through merger, consolidation, reorganization, recapitalization, reincorporation, stock dividend, dividend in property other than cash, large nonrecurring cash dividend, stock split, reverse stock split, liquidating dividend, combination of shares, exchange of shares, change in corporate structure, or any similar equity restructuring transaction, as that term is used in Statement of Financial Accounting Standards Board Accounting Standards Codification Topic 718 (or any successor thereto). Notwithstanding the foregoing, the conversion of any convertible securities of the Company will not be treated as a Capitalization Adjustment.
(f) Cause will have the meaning ascribed to the term in any written agreement between the Participant and the Company or an Affiliate defining the term and, in the absence of such an agreement, the term means, with respect to a Participant, the occurrence of any of the following events: (i) the Participants commission of any felony or any crime involving fraud, dishonesty or moral turpitude under the laws of the United States or any state thereof; (ii) such Participants attempted commission of, or participation in, a fraud or act of dishonesty against the Company; (iii) such Participants intentional, material violation of any contract or agreement between the Participant and the Company or of any statutory duty owed to the Company; (iv) such Participants unauthorized use or disclosure of the Companys confidential information or trade secrets; or (v) such Participants gross misconduct. The determination that a termination of the Participants Continuous Service is either for Cause or without Cause will be made by the Board or Committee, as applicable, in its sole and exclusive judgment and discretion. Any determination by the Company that the Continuous Service of a Participant was terminated with or without Cause for the purposes of outstanding Awards held by such Participant will have no effect upon any determination of the rights or obligations of the Company or such Participant for any other purpose.
(g) Code means the Internal Revenue Code of 1986, as amended, including any applicable regulations and guidance thereunder.
(h) Committee means a committee of two or more Directors to whom the Board has delegated authority in accordance with Section 2(c).
(i) Common Stock means the common stock of the Company.
(j) Company means Intra-Cellular Therapies, Inc., a Delaware corporation.
(k) Consultant means any person, including an advisor, who is (i) engaged by the Company or an Affiliate to render consulting or advisory services and is compensated for those services, or (ii) serving as a member of the board of directors of an Affiliate and is compensated for those services. However, service solely as a Director, or payment of a fee for such service, will not cause a Director to be considered a Consultant for purposes of the Plan. Notwithstanding the foregoing, a person is treated as a Consultant under this Plan only if a Form S-8 Registration Statement under the Securities Act is available to register either the offer or the sale of the Companys securities to such person. Consultants are not eligible to receive Awards under the Plan with respect to their service in such capacity.
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(l) Continuous Service means that the Participants service with the Company or an Affiliate, whether as an Employee, Director or Consultant, is not interrupted or terminated. A change in the capacity in which the Participant renders service to the Company or an Affiliate as an Employee, Consultant or Director or a change in the Entity for which the Participant renders service, provided that there is no interruption or termination of the Participants service with the Company or an Affiliate, will not terminate a Participants Continuous Service; provided, however, that if the Entity for which a Participant is rendering services ceases to qualify as an Affiliate, as determined by the Board in its sole discretion, the Participants Continuous Service will be considered to have terminated on the date the Entity ceases to qualify as an Affiliate. For example, a change in status from an Employee of the Company to a Consultant of an Affiliate or to a Director will not constitute an interruption of Continuous Service. To the extent permitted by law, the Board or the chief executive officer of the Company, in that partys sole discretion, may determine whether Continuous Service will be considered interrupted in the case of (i) any leave of absence approved by the Board or chief executive officer, including sick leave, military leave or any other personal leave; or (ii) transfers between the Company, an Affiliate, or their successors. Notwithstanding the foregoing, a leave of absence will be treated as Continuous Service for purposes of vesting in an Award only to such extent as may be provided in the Companys leave of absence policy, in the written terms of any leave of absence agreement or policy applicable to the Participant, or as otherwise required by law.
(m) Corporate Transaction means the consummation, in a single transaction or in a series of related transactions, of any one or more of the following events:
(i) a sale or other disposition of all or substantially all, as determined by the Board, in its sole discretion, of the consolidated assets of the Company and its Subsidiaries;
(ii) a sale or other disposition of at least 90% of the outstanding securities of the Company;
(iii) a merger, consolidation or similar transaction following which the Company is not the surviving corporation; or
(iv) a merger, consolidation or similar transaction following which the Company is the surviving corporation but the shares of Common Stock outstanding immediately preceding the merger, consolidation or similar transaction are converted or exchanged by virtue of the merger, consolidation or similar transaction into other property, whether in the form of securities, cash or otherwise.
(n) Director means a member of the Board. Directors are not eligible to receive Awards under the Plan with respect to their service in such capacity.
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(o) Disability means, with respect to a Participant, the inability of the Participant to engage in any substantial gainful activity by reason of any medically determinable physical or mental impairment that can be expected to result in death or that has lasted or can be expected to last for a continuous period of not less than 12 months as provided in Sections 22(e)(3) and 409A(a)(2)(c)(i) of the Code, and will be determined by the Board on the basis of any medical evidence the Board determines warranted under the circumstances.
(p) Effective Date means December 16, 2019 which is the date this Plan was originally approved by the Compensation Committee of the Board.
(q) Employee means any person employed by the Company or an Affiliate. However, service solely as a Director, or payment of a fee for such services, will not cause a Director to be considered an Employee for purposes of the Plan.
(r) Entity means a corporation, partnership, limited liability company or other entity.
(s) Exchange Act means the Securities Exchange Act of 1934, as amended, and the rules and regulations promulgated thereunder.
(t) Fair Market Value means, as of any date, the value of the Common Stock determined as follows:
(i) If the Common Stock is listed on any established stock exchange or traded on any established market, the Fair Market Value of a share of Common Stock will be, unless otherwise determined by the Board, the closing sales price for such stock as quoted on such exchange or market (or the exchange or market with the greatest volume of trading in the Common Stock) on the date of determination, as reported in a source the Board deems reliable.
(ii) Unless otherwise provided by the Board, if there is no closing sales price for the Common Stock on the date of determination, then the Fair Market Value will be the closing selling price on the last preceding date for which such quotation exists.
(iii) In the absence of such markets for the Common Stock, the Fair Market Value will be determined by the Board in good faith and in a manner that complies with Section 409A of the Code.
(u) Non-Employee Director means a Director who either (i) is not a current employee or officer of the Company or an Affiliate, does not receive compensation, either directly or indirectly, from the Company or an Affiliate for services rendered as a consultant or in any capacity other than as a Director (except for an amount as to which disclosure would not be required under Item 404(a) of Regulation S-K promulgated pursuant to the Securities Act (Regulation S-K)), does not possess an interest in any other transaction for which disclosure would be required under Item 404(a) of Regulation S-K, and is not engaged in a business relationship for which disclosure would be required pursuant to Item 404(b) of Regulation S-K; or (ii) is otherwise considered a non-employee director for purposes of Rule 16b-3.
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(v) Nonstatutory Stock Option means any option granted pursuant to Section 5 of the Plan that does not qualify as an incentive stock option within the meaning of Section 422 of the Code.
(w) Officer means a person who is an officer of the Company within the meaning of Section 16 of the Exchange Act.
(x) Option means a Nonstatutory Stock Option to purchase shares of Common Stock granted under the Plan.
(y) Option Agreement means a written agreement between the Company and an Optionholder evidencing the terms and conditions of an Option. Each Option Agreement will be subject to the terms and conditions of the Plan.
(z) Optionholder means a person to whom an Option is granted pursuant to the Plan or, if applicable, any other person who holds an outstanding Option.
(aa) Other Stock Award means an award based in whole or in part by reference to the Common Stock that is granted pursuant to the terms and conditions of Section 6(c).
(bb) Other Stock Award Agreement means a written agreement between the Company and a holder of an Other Stock Award evidencing the terms and conditions of an Other Stock Award grant. Each Other Stock Award Agreement will be subject to the terms and conditions of the Plan.
(cc) Participant means a person to whom an Award is granted under the Plan or, if applicable, any other person who holds an outstanding Award.
(dd) Plan means this Intra-Cellular Therapies, Inc. 2019 Inducement Award Plan.
(ee) Restricted Stock Award means an award of shares of Common Stock that is granted pursuant to the terms and conditions of Section 6(a).
(ff) Restricted Stock Award Agreement means a written agreement between the Company and a holder of a Restricted Stock Award evidencing the terms and conditions of a Restricted Stock Award. Each Restricted Stock Award Agreement will be subject to the terms and conditions of the Plan.
(gg) Restricted Stock Unit Award means a right to receive shares of Common Stock which is granted pursuant to the terms and conditions of Section 6(b).
(hh) Restricted Stock Unit Award Agreement means a written agreement between the Company and a holder of a Restricted Stock Unit Award evidencing the terms and conditions of a Restricted Stock Unit Award grant. Each Restricted Stock Unit Award Agreement will be subject to the terms and conditions of the Plan.
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(ii) Rule 16b-3 means Rule 16b-3 promulgated under the Exchange Act or any successor to Rule 16b-3, as in effect from time to time.
(jj) Securities Act means the Securities Act of 1933, as amended.
(kk) Stock Appreciation Right or SAR means a right to receive the appreciation on Common Stock that is granted pursuant to the terms and conditions of Section 5.
(ll) Stock Appreciation Right Agreement means a written agreement between the Company and a holder of a Stock Appreciation Right evidencing the terms and conditions of a Stock Appreciation Right. Each Stock Appreciation Right Agreement will be subject to the terms and conditions of the Plan.
(mm) Stock Award means any right to receive Common Stock granted under the Plan, including a Nonstatutory Stock Option, a Restricted Stock Award, a Restricted Stock Unit Award, a Stock Appreciation Right, or any Other Stock Award.
(nn) Stock Award Agreement means a written agreement between the Company and a Participant evidencing the terms and conditions of a Stock Award grant. Each Stock Award Agreement will be subject to the terms and conditions of the Plan.
(oo) Subsidiary means, with respect to the Company, (i) any corporation of which more than 50% of the outstanding capital stock having ordinary voting power to elect a majority of the board of directors of such corporation (irrespective of whether, at the time, stock of any other class or classes of such corporation will have or might have voting power by reason of the happening of any contingency) is at the time, directly or indirectly, owned by the Company; and (ii) any partnership, limited liability company or other Entity in which the Company has a direct or indirect interest (whether in the form of voting or participation in profits or capital contribution) of more than 50%.
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Exhibit 10.33
Restricted Stock Unit No.________
INTRA-CELLULAR THERAPIES, INC.
Restricted Stock Unit Award Grant Notice
Restricted Stock Unit Award Grant under the Companys
2019 Inducement Award Plan
1. |
Name and Address of Participant: |
|||
2. | Date of Grant of Restricted Stock Unit Award: | |||
3. | Maximum Number of Shares underlying Restricted Stock Unit Award: | |||
4. | Vesting Commencement Date: | |||
5. | Vesting Schedule: Subject to Section 2 of the Restricted Stock Unit Award Agreement, the Restricted Stock Unit Award will vest as follows: [_________]. |
The Participant acknowledges receipt of this Restricted Stock Unit Award Grant Notice and agrees to the terms of the Restricted Stock Unit Award Agreement attached hereto and incorporated by reference herein, the Companys 2019 Inducement Award Plan and the terms of this Restricted Stock Unit Award as set forth above.
INTRA-CELLULAR THERAPIES, INC. |
By: | ||
Name: | ||
Title: |
|
Participant |
ATTACHMENTS: Restricted Stock Unit Award Agreement and 2019 Inducement Award Plan
INTRA-CELLULAR THERAPIES, INC.
2019 INDUCEMENT AWARD PLAN
RESTRICTED STOCK UNIT AWARD AGREEMENT
This Restricted Stock Unit Award Agreement (this Agreement) is made as of the date of grant set forth in the Restricted Stock Unit Award Grant Notice between INTRA-CELLULAR THERAPIES, INC. (the Company), a Delaware corporation, and the individual whose name appears on the Restricted Stock Unit Award Grant Notice (the Participant).
WHEREAS, the Company has adopted the Intra-Cellular Therapies, Inc. 2019 Inducement Award Plan (the Plan) to promote the interests of the Company by providing an incentive for Employees of the Company and its Affiliates;
WHEREAS, pursuant to the provisions of the Plan, the Company desires to grant to the Participant restricted stock units (RSUs) related to the Companys Common Stock, in accordance with the provisions of the Plan, all on the terms and conditions hereinafter set forth; and
WHEREAS, the Company and the Participant understand and agree that any terms used and not defined herein have the meanings ascribed to such terms in the Plan.
NOW, THEREFORE, in consideration of the promises and the mutual covenants contained herein and for other good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, the parties hereto hereby agree as follows:
1. Grant of Award. The Company hereby grants to the Participant an award for the number of RSUs set forth in the Restricted Stock Unit Award Grant Notice (the Award). Each RSU represents a contingent entitlement of the Participant to receive one share of Common Stock, on the terms and conditions and subject to all the limitations set forth herein and in the Plan, which is incorporated herein by reference. The Participant acknowledges receipt of a copy of the Plan.
2. Vesting of Award.
(a) Subject to the terms and conditions set forth in this Agreement and the Plan, the Award granted hereby shall vest as set forth in the Restricted Stock Unit Award Grant Notice, provided that vesting shall cease upon the termination of the Participants Continuous Service.
(b) Except as otherwise set forth in this Agreement, if the Participant ceases to be in Continuous Service for any reason prior to a vesting date set forth in the Restricted Stock Unit Award Grant Notice, then as of the date on which the Participants Continuous Service terminates, all unvested RSUs shall immediately be forfeited to the Company and this Agreement shall terminate and be of no further force or effect. Notwithstanding the foregoing, if (a) the Participant is an Employee at the level of Vice President or above at the time of a termination of the Participants Continuous Service and, at any time within ninety (90) days prior to or twelve (12) months following the effective date of a Change in Control (or such other period as is, or may be, set forth in an employment, severance or other similar written agreement between the Participant and the Company or any of its Affiliates), or (b) the Participant is an Employee below the level of Vice President or a Consultant at the time of a termination of the
Participants Continuous Service and, at any time within twelve (12) months following the effective date of a Change in Control, the Participants Continuous Service terminates by reason of (i) a resignation for Good Reason or (ii) an involuntary termination of the Participants Continuous Service without Cause (each, a Qualifying Termination), then any RSUs underlying this Award that have not become vested and that are outstanding at the time of the Qualifying Termination (whether pursuant to this Agreement or other action of the Board or the Committee) shall become fully vested as of (x) the effective date of the Change in Control if the Participants Qualifying Termination occurs prior to the effective date of the Change in Control and (y) the date of such Qualifying Termination if the Participants Qualifying Termination occurs on or after the effective date of the Change in Control. In order to give effect to the intent of such accelerated vesting, if the Participants Qualifying Termination occurs prior to the effective date of a Change in Control, then notwithstanding anything to the contrary in this Agreement or the Plan, in no event will any portion of this Award or Agreement be forfeited or terminate any earlier than the effective date of the Change in Control.
The following terms shall have the following meanings for purposes of this Section 2:
Change in Control means the occurrence of any of the following events: (i) any Person (as such term is used in Sections 13(d) and 14(d) of the Exchange Act) becomes the Beneficial Owner (as defined in Rule 13d-3 under the Exchange Act), directly or indirectly, of securities of the Company representing 50% or more of the total voting power represented by the Companys then outstanding voting securities (excluding for this purpose any such voting securities held by the Company or its affiliates or by any employee benefit plan of the Company) pursuant to a transaction or a series of related transactions; or (ii)(a) a merger or consolidation of the Company whether or not approved by the Board, other than a merger or consolidation which would result in the voting securities of the Company outstanding immediately prior thereto continuing to represent (either by remaining outstanding or by being converted into voting securities of the surviving entity or the parent of such corporation) more than 50% of the total voting power represented by the voting securities of the Company or such surviving entity or parent of such corporation, as the case may be, outstanding immediately after such merger or consolidation; or (b) the sale or disposition by the Company of all or substantially all of the Companys assets in a transaction requiring stockholder approval.
Good Reason means the occurrence of (a) any event constituting Good Reason (or an analogous term) as set forth in any employment, consulting, severance or other similar written agreement between the Participant and the Company or any of its Affiliates and (b) any of the following events without the consent of the Participant: (i) if the Participant is an Employee at the level of Vice President or above, a material reduction or change in job duties, responsibilities or authority inconsistent with the Participants position with the Company and the Participants prior duties, responsibilities or authority immediately prior to the Change in Control; (ii) for any Employee or Consultant, a relocation of the Participants primary workplace by more than 25 miles; or (iii) for any Employee or Consultant, a material reduction of the Participants base compensation; provided, however, that any event described in clause (b) above shall constitute Good Reason only if (x) the Participant provides the Company with written notice specifying the event alleged to constitute Good Reason within 60 days following the first occurrence of such event, (y) the Company fails to cure such event within
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30 days after the Companys receipt from the Participant of such written notice, and (z) the Participants termination of Continuous Service occurs within 30 days following the Companys failure to cure such event (and in no event later than 120 days following the first occurrence of such event).
3. Issuance of Shares.
(a) The issuance of any shares of Common Stock in respect of this Award is (i) subject to satisfaction of the tax withholding obligations set forth in Section 9 and (ii) intended to comply with Treasury Regulations Section 1.409A-1(b)(4) and will be construed and administered in such a manner. The form of such issuance (e.g., a stock certificate or electronic entry evidencing such shares) will be determined by the Company.
(b) In the event one or more RSUs subject to this Award vests, the Company will issue to the Participant, on the applicable vesting date, one share of Common Stock for each RSU that vests on such date (and for purposes of this Agreement, such issuance date is referred to as the Original Issuance Date); provided, however, that if the Original Issuance Date falls on a date that is not a business day, such shares will instead be issued to the Participant on the next following business day.
(c) Notwithstanding the foregoing, if:
(i) this Award is otherwise subject to withholding taxes (as described in Section 9) on the Original Issuance Date,
(ii) the Original Issuance Date does not occur (x) during an open window period applicable to the Participant, as determined by the Company in accordance with the Companys then-effective policy on trading in Company securities, or (y) on a date when the Participant is otherwise permitted to sell shares of Common Stock on an established stock exchange or stock market, and
(iii) the Company elects, prior to the Original Issuance Date, (x) not to satisfy such withholding taxes by withholding shares of Common Stock from the shares of Common Stock otherwise due, on the Original Issuance Date, to the Participant under this Award, (y) not to permit the Participant to enter into a same day sale commitment with a broker-dealer pursuant to Section 9 (including, but not limited to, under a previously established 10b5-1 trading plan entered into in compliance with the Companys policies), and (z) not to permit the Participant to pay such withholding taxes in cash,
then the shares that would otherwise be issued to the Participant on the Original Issuance Date will not be issued to the Participant on the Original Issuance Date and will instead be issued to the Participant on the first business day when the Participant is not prohibited from selling shares of Common Stock on an established stock exchange or stock market, but in no event later than December 31 of the calendar year in which the Original Issuance Date occurs (that is, the last day of the Participants taxable year in which the Original Issuance Date occurs), or, if permitted in a manner that complies with Treasury Regulations Section 1.409A-1(b)(4), no later than the date that is the 15th day of the third calendar month of the year following the year in which the shares of Common Stock in respect of this Award are no longer subject to a substantial risk of forfeiture within the meaning of Treasury Regulations Section 1.409A-1(d).
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4. Prohibitions on Transfer and Sale. This Award (including any additional RSUs received by the Participant as a result of stock dividends, stock splits or any other similar transaction affecting the Companys securities without receipt of consideration) shall not be transferable by the Participant otherwise than (i) by will or by the laws of descent and distribution, or (ii) pursuant to a qualified domestic relations order as defined by the Internal Revenue Code or Title I of the Employee Retirement Income Security Act or the rules thereunder. Except as provided in the previous sentence, the shares of Common Stock to be issued pursuant to this Agreement shall be issued, during the Participants lifetime, only to the Participant (or, in the event of legal incapacity or incompetence, to the Participants guardian or representative). This Award shall not be assigned, pledged or hypothecated in any way (whether by operation of law or otherwise) and shall not be subject to execution, attachment or similar process. Any attempted transfer, assignment, pledge, hypothecation or other disposition of this Award or of any rights granted hereunder contrary to the provisions of this Section 4, or the levy of any attachment or similar process upon this Award shall be null and void.
5. Adjustments. The Plan contains provisions covering the treatment of RSUs and shares of Common Stock in a number of contingencies such as Capitalization Adjustments and Corporate Transactions. Provisions in the Plan for adjustment with respect to this Award and the related provisions with respect to successors to the business of the Company are hereby made applicable hereunder and are incorporated herein by reference.
6. Securities Law Compliance. The Participant specifically acknowledges and agrees that any sales of shares of Common Stock shall be made in accordance with the requirements of the Securities Act. The Company currently has an effective registration statement on file with the Securities and Exchange Commission with respect to the Common Stock to be granted hereunder. The Company intends to maintain this registration statement but has no obligation to do so. If the registration statement ceases to be effective for any reason, Participant will not be able to transfer or sell any of the shares of Common Stock issued to the Participant pursuant to this Agreement unless exemptions from registration or filings under applicable securities laws are available. Furthermore, despite registration, applicable securities laws may restrict the ability of the Participant to sell his or her Common Stock, including due to the Participants affiliation with the Company. The Company shall not be obligated to either issue the Common Stock or permit the resale of any shares of Common Stock if such issuance or resale would violate any applicable securities law, rule or regulation.
7. Rights as a Stockholder. The Participant shall have no right as a stockholder, including voting and dividend rights, with respect to the RSUs subject to this Agreement.
8. Incorporation of the Plan. The Participant specifically understands and agrees that the RSUs and the shares of Common Stock to be issued under the Plan will be issued to the Participant pursuant to the Plan, a copy of which Plan the Participant acknowledges he or she has read and understands and by which Plan he or she agrees to be bound. The provisions of the Plan are incorporated herein by reference. In addition, this RSU (and any compensation paid or shares issued pursuant to this Agreement) is subject to recoupment in accordance with The DoddFrank Wall Street Reform and Consumer Protection Act and any implementing regulations thereunder, any clawback policy adopted by the Company and any compensation recovery policy otherwise required by applicable law. No recovery of compensation under such a clawback policy will be an event giving rise to a right to resign for good reason or for a constructive termination (or similar term) under any agreement with the Company.
9. Tax Liability of the Participant and Payment of Taxes. The Participant acknowledges and agrees that any income or other taxes due from the Participant with respect to this Award or the shares of Common Stock to be issued pursuant to this Agreement or otherwise sold shall be the Participants responsibility. Without limiting the foregoing, the Participant
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agrees that if under applicable law the Participant will owe taxes at each vesting or settlement date on the portion of the Award then vested or settled, as applicable, the Company shall be entitled to immediate payment from the Participant of the amount of any tax or other amounts required to be withheld by the Company by applicable law or regulation. Any taxes or other amounts due shall be paid as follows:
(a) subject to approval by the Board or Committee, as applicable, through reducing the number of shares of Common Stock entitled to be issued to the Participant on the applicable settlement date in an amount not in excess of the maximum amount of tax required to be withheld by law (or such other amount as may be necessary to avoid classification of this Award as a liability for financial accounting purposes). Fractional shares will not be retained to satisfy any portion of the Companys withholding obligation. Accordingly, the Participant agrees that in the event that the amount of withholding required would result in a fraction of a share being owed, that amount will be satisfied by withholding the fractional amount from the Participants paycheck;
(b) at the option of the Company, by requiring the Participant to deposit with the Company an amount of cash equal to the amount determined by the Company to be required to be withheld with respect to the statutory minimum amount of the Participants total tax and other withholding obligations due and payable by the Company or otherwise withholding from the Participants paycheck an amount equal to such amounts due and payable by the Company; or
(c) if the Company believes that the sale of shares can be made in compliance with applicable securities laws, authorizing, at a time when the Participant is not in possession of material nonpublic information, the sale by the Participant on the applicable vesting date of such number of shares of Common Stock as necessary to sell to satisfy the Companys withholding obligation, after deduction of the brokers commission, and the broker shall be required to remit to the Company the cash necessary in order for the Company to satisfy its withholding obligation. To the extent the proceeds of such sale exceed the Companys withholding obligation, the Company agrees to pay such excess cash to the Participant as soon as practicable. In addition, if such sale is not sufficient to pay the Companys withholding obligation, the Participant agrees to pay to the Company as soon as practicable, including through additional payroll withholding, the amount of any withholding obligation that is not satisfied by the sale of shares of Common Stock. The Participant agrees to hold the Company and the broker harmless from all costs, damages or expenses relating to any such sale. The Participant acknowledges that the broker is under no obligation to arrange for such sale at any particular price. In connection with such sale of shares of Common Stock, the Participant shall execute any such documents requested by the broker in order to effectuate the sale of shares of Common Stock and payment of the withholding obligation to the Company. The Participant acknowledges that this paragraph is intended to comply with Section 10b5-1(c)(1)(i)(B) under the Exchange Act.
The Company shall not deliver any shares of Common Stock to the Participant until it is satisfied that all required withholdings have been made.
10. Participant Acknowledgements and Authorizations.
The Participant acknowledges the following:
(a) The Company is not by the Plan or this Award obligated to continue the Participant as an employee, director or consultant of the Company or an Affiliate.
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(b) The Plan is discretionary in nature and may be suspended or terminated by the Company at any time.
(c) The grant of this Award is considered a one-time benefit and does not create a contractual or other right to receive any other award under the Plan, benefits in lieu of awards or any other benefits in the future.
(d) The Plan is a voluntary program of the Company and future awards, if any, will be at the sole discretion of the Company, including, but not limited to, the timing of any grant, the amount of any award, vesting provisions and the purchase price, if any.
(e) The value of this Award is an extraordinary item of compensation outside of the scope of the Participants employment or consulting contract, if any. As such the Award is not part of normal or expected compensation for purposes of calculating any severance, resignation, redundancy, end of service payments, bonuses, long-service awards, pension or retirement benefits or similar payments. The future value of the shares of Common Stock is unknown and cannot be predicted with certainty.
(f) The Participant (i) authorizes the Company and each Affiliate and any agent of the Company or any Affiliate administering the Plan or providing Plan recordkeeping services, to disclose to the Company or any of its Affiliates such information and data as the Company or any such Affiliate shall request in order to facilitate the grant of the Award and the administration of the Plan; and (ii) authorizes the Company and each Affiliate to store and transmit such information in electronic form for the purposes set forth in this Agreement.
11. Notices. Any notices required or permitted by the terms of this Agreement or the Plan shall be given by recognized courier service, facsimile, registered or certified mail, return receipt requested, addressed as follows:
If to the Company:
430 East 29th Street
New York, New York 10016
Attn: General Counsel
If to the Participant at the address set forth on the Restricted Stock Unit Award Grant Notice or to such other address or addresses of which notice in the same manner has previously been given.
Any such notice shall be deemed to have been given on the earliest of receipt, one business day following delivery by the sender to a recognized courier service, or three business days following mailing by registered or certified mail.
12. Assignment and Successors.
(a) This Agreement is personal to the Participant and without the prior written consent of the Company shall not be assignable by the Participant otherwise than by will or the laws of descent and distribution. This Agreement shall inure to the benefit of and be enforceable by the Participants legal representatives.
(b) This Agreement shall inure to the benefit of and be binding upon the Company and its successors and assigns.
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13. Governing Law. This Agreement shall be construed and enforced in accordance with the laws of the State of Delaware, without giving effect to the conflict of law principles thereof. For the purpose of litigating any dispute that arises under this Agreement, whether at law or in equity, the parties hereby consent to exclusive jurisdiction in the state of New York and agree that such litigation shall be conducted in the state courts of the state of New York or the federal courts of the United States for the District of Manhattan.
14. Severability. If any provision of this Agreement is held to be invalid or unenforceable by a court of competent jurisdiction, then such provision or provisions shall be modified to the extent necessary to make such provision valid and enforceable, and to the extent that this is impossible, then such provision shall be deemed to be excised from this Agreement, and the validity, legality and enforceability of the rest of this Agreement shall not be affected thereby.
15. Entire Agreement. This Agreement, together with the Plan, constitutes the entire agreement and understanding between the parties hereto with respect to the subject matter hereof and supersedes all prior oral or written agreements and understandings relating to the subject matter hereof. No statement, representation, warranty, covenant or agreement not expressly set forth in this Agreement shall affect or be used to interpret, change or restrict the express terms and provisions of this Agreement; provided, however, in any event, this Agreement shall be subject to and governed by the Plan.
16. Modifications and Amendments; Waivers and Consents. The terms and provisions of this Agreement may be modified or amended as provided in the Plan. Except as provided in the Plan, the terms and provisions of this Agreement may be waived, or consent for the departure therefrom granted, only by written document executed by the party entitled to the benefits of such terms or provisions. No such waiver or consent shall be deemed to be or shall constitute a waiver or consent with respect to any other terms or provisions of this Agreement, whether or not similar. Each such waiver or consent shall be effective only in the specific instance and for the purpose for which it was given, and shall not constitute a continuing waiver or consent.
17. Section 409A. The Award of RSUs evidenced by this Agreement is intended to be exempt from the nonqualified deferred compensation rules of Section 409A of the Code as a short term deferral (as that term is used in the final regulations and other guidance issued under Section 409A of the Code, including Treasury Regulation Section 1.409A-1(b)(4)(i)), and shall be construed accordingly. However, if (i) this Award fails to satisfy the requirements of the short-term deferral rule and is otherwise not exempt from, and therefore deemed to be deferred compensation subject to, Section 409A of the Code, (ii) the Participant is deemed by the Company at the time of the Participants separation from service (as such term is defined in Treasury Regulations Section 1.409A-1(h) without regard to any alternative definition thereunder) to be a specified employee for purposes of Section 409A(a)(2)(B)(i) of the Code, and (iii) any of the payments set forth herein are issuable upon such separation from service, then to the extent delayed commencement of any portion of such payments is required to avoid a prohibited distribution under Section 409A(a)(2)(B)(i) of the Code and the related adverse taxation under Section 409A of the Code, such payments will not be provided to the Participant prior to the earliest of (a) the date that is six (6) months and one (1) day after the date of such separation from service, (b) the date of the Participants death, or (c) such earlier date as permitted under Section 409A of the Code without the imposition of adverse taxation. Upon the first business day following the expiration of such applicable Code Section 409A(a)(2)(B)(i) period, all payments deferred pursuant to this Section 17 will be paid in a lump sum to the Participant, and any remaining payments due will be paid as otherwise provided herein. Each installment of RSUs that vests under this Award is a separate payment for purposes of Treasury Regulations Section 1.409A-2(b)(2).
[REMAINDER OF PAGE INTENTIONALLY LEFT BLANK]
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Exhibit 10.34
INTRA-CELLULAR THERAPIES, INC.
2019 INDUCEMENT AWARD PLAN
OPTION GRANT NOTICE
Intra-Cellular Therapies, Inc. (the Company), pursuant to its 2019 Inducement Award Plan (the Plan), hereby grants to Optionholder an option to purchase the number of shares of Common Stock set forth below (the Option). The Option is subject to all of the terms and conditions set forth in this Option Grant Notice (Notice), in the Option Agreement and the Plan, both of which are attached to this Notice and incorporated into this Notice in their entirety. Capitalized terms not explicitly defined in this Notice but defined in the Plan or the Option Agreement will have the same definitions as in the Plan or the Option Agreement. If there is any conflict between the terms in this Notice and the Plan, the terms of the Plan will control.
Optionholder: | ||
Date of Grant: | ||
Vesting Commencement Date: | ||
Number of Shares Subject to Option: | ||
Exercise Price (Per Share): | ||
Total Exercise Price: | ||
Expiration Date: |
Type of Grant: Nonstatutory Stock Option
Vesting Schedule: Subject to Section 1 of the Option Agreement, the Option will vest as follows: [ ].
Additional Terms/Acknowledgements: Optionholder acknowledges receipt of, and understands and agrees to, this Notice, the Option Agreement, the Plan and the stock plan prospectus for the Plan. Optionholder acknowledges and agrees that this Notice and the Option Agreement may not be modified, amended or revised except as provided in the Plan. Optionholder further acknowledges that as of the Date of Grant, this Notice, the Option Agreement, and the Plan set forth the entire understanding between Optionholder and the Company regarding the Option and supersede all prior oral and written agreements, promises and representations on that subject.
INTRA-CELLULAR THERAPIES, INC.: | OPTIONHOLDER: | |||||||
By: | ||||||||
Signature | Signature | |||||||
Title: | Date: | |||||||
Date: |
ATTACHMENTS: Option Agreement and 2019 Inducement Award Plan
INTRA-CELLULAR THERAPIES, INC.
2019 INDUCEMENT AWARD PLAN
OPTION AGREEMENT
(NONSTATUTORY STOCK OPTION)
Pursuant to your Option Grant Notice (the Grant Notice) and this Option Agreement, Intra-Cellular Therapies, Inc. (the Company) has granted you an option under its 2019 Inducement Award Plan (the Plan) to purchase the number of shares of Common Stock indicated in your Grant Notice at the exercise price indicated in your Grant Notice. The option is granted to you effective as of the date of grant set forth in the Grant Notice (the Date of Grant). If there is any conflict between the terms in this Option Agreement and the Plan, the terms of the Plan will control. Capitalized terms not explicitly defined in this Option Agreement or in the Grant Notice but defined in the Plan will have the same definitions as in the Plan.
The details of your option, in addition to those set forth in the Grant Notice and the Plan, are as follows:
1. VESTING. Your option will vest as provided in your Grant Notice. Vesting will cease upon the termination of your Continuous Service and the number of shares of Common Stock which are unvested as of such date shall be forfeited. Notwithstanding the foregoing, if (a) you are an Employee at the level of Vice President or above at the time of a termination of your Continuous Service and, at any time within ninety (90) days prior to or twelve (12) months following the effective date of a Change in Control (or such other period as is, or may be, set forth in an employment, severance or other similar written agreement between you and the Company or any of its Affiliates), or (b) you are an Employee below the level of Vice President or a Consultant at the time of a termination of your Continuous Service and, at any time within twelve (12) months following the effective date of a Change in Control, your Continuous Service terminates by reason of (i) a resignation for Good Reason or (ii) an involuntary termination of your Continuous Service without Cause (each, a Qualifying Termination), then any shares underlying this Option that have not become vested and that are outstanding at the time of the Qualifying Termination (whether pursuant to this Option Agreement or other action of the Board or the Committee) shall become fully vested and exercisable as of (x) the effective date of the Change in Control if your Qualifying Termination occurs prior to the effective date of the Change in Control and (y) the date of such Qualifying Termination if your Qualifying Termination occurs on or after the effective date of the Change in Control. In order to give effect to the intent of such accelerated vesting, if your Qualifying Termination occurs prior to the effective date of a Change in Control, then notwithstanding anything to the contrary in this Option Agreement or the Plan, in no event will any portion of your option or this Option Agreement be forfeited or terminate any earlier than the effective date of the Change in Control.
The following terms shall have the following meanings for purposes of this Section 1:
Change in Control means the occurrence of any of the following events: (i) any Person (as such term is used in Sections 13(d) and 14(d) of the Exchange Act) becomes the Beneficial Owner (as defined in Rule 13d-3 under the Exchange Act), directly or indirectly, of securities of the Company representing 50% or more of the total voting power represented by the Companys then outstanding voting securities (excluding for this purpose any such voting securities held by the Company or its affiliates or by any employee benefit plan of the Company) pursuant to a transaction or a series of related transactions; or (ii)(a) a merger or consolidation of the Company whether or not approved by the Board, other than a merger or consolidation which would result in the voting
1.
securities of the Company outstanding immediately prior thereto continuing to represent (either by remaining outstanding or by being converted into voting securities of the surviving entity or the parent of such corporation) more than 50% of the total voting power represented by the voting securities of the Company or such surviving entity or parent of such corporation, as the case may be, outstanding immediately after such merger or consolidation; or (b) the sale or disposition by the Company of all or substantially all of the Companys assets in a transaction requiring stockholder approval.
Good Reason means the occurrence of (a) any event constituting Good Reason (or an analogous term) as set forth in any employment, consulting, severance or other similar written agreement between you and the Company or any of its Affiliates and (b) any of the following events without your consent: (i) if you are an Employee at the level of Vice President or above, a material reduction or change in job duties, responsibilities or authority inconsistent with your position with the Company and your prior duties, responsibilities or authority immediately prior to the Change in Control; (ii) for any Employee or Consultant, a relocation of your primary workplace by more than 25 miles; or (iii) for any Employee or Consultant, a material reduction of your base compensation; provided, however, that any event described in clause (b) above shall constitute Good Reason only if (x) you provide the Company with written notice specifying the event alleged to constitute Good Reason within 60 days following the first occurrence of such event, (y) the Company fails to cure such event within 30 days after the Companys receipt from you of such written notice, and (z) your termination of Continuous Service occurs within 30 days following the Companys failure to cure such event (and in no event later than 120 days following the first occurrence of such event).
2. NUMBER OF SHARES AND EXERCISE PRICE. The number of shares of Common Stock subject to your option and your exercise price per share in your Grant Notice will be adjusted for Capitalization Adjustments as provided in the Plan.
3. METHOD OF PAYMENT. You must pay the full amount of the exercise price for the shares you wish to exercise. You may pay the exercise price as follows:
(a) In cash or by check, bank draft or money order payable to the Company.
(b) Provided that at the time of exercise the Common Stock is publicly traded, pursuant to a program developed under Regulation T as promulgated by the Federal Reserve Board that, prior to the issuance of Common Stock, results in either the receipt of cash or check by the Company or the receipt of irrevocable instructions to pay the aggregate exercise price to the Company from the sales proceeds. This manner of payment is also known as a broker-assisted exercise, same day sale, or sell to cover.
(c) Provided that at the time of exercise the Common Stock is publicly traded, by delivery to the Company (either by actual delivery or attestation) of already-owned shares of Common Stock that are owned free and clear of any liens, claims, encumbrances or security interests, with a Fair Market Value on the date of exercise that does not exceed the aggregate exercise price. You must pay any remaining balance of the aggregate exercise price not satisfied by such delivery in cash or other permitted form of payment. Delivery for these purposes, in the sole discretion of the Company at the time you exercise your option, will include delivery to the Company of your attestation of ownership of the shares of Common Stock in a form the Company approves. You may not exercise your option by delivery to the Company of Common Stock if doing so would violate the provisions of any law, regulation or agreement restricting the redemption of the Companys stock.
2.
(d) Subject to the consent of the Board or Committee, as applicable, prior to exercise, by a net exercise arrangement pursuant to which the Company will reduce the number of shares of Common Stock otherwise issuable to you upon exercise of your option by the largest whole number of shares with a Fair Market Value on the date of exercise that does not exceed the aggregate exercise price. You must pay any remaining balance of the aggregate exercise price not satisfied by the net exercise in cash or other permitted form of payment.
4. WHOLE SHARES. You may exercise your option only for whole shares of Common Stock.
5. SECURITIES LAW COMPLIANCE. In no event may you exercise your option unless the shares of Common Stock issuable upon exercise are then registered under the Securities Act or, if not registered, the Company has determined that your exercise and the issuance of the shares would be exempt from the registration requirements of the Securities Act. The exercise of your option also must comply with all other applicable laws and regulations governing your option, and you may not exercise your option if the Company determines that the exercise would not be in material compliance with applicable laws and regulations.
6. TERM. The term of your option expires upon the earliest of the following:
(a) immediately upon notification to you of a termination of your Continuous Service for Cause;
(b) three months after the termination of your Continuous Service for any reason other than Cause, your Disability or your death, except as otherwise provided in Sections 6(d) and 6(e) below; provided, however, that if during any part of such three month period your option is not exercisable solely because doing so would violate the registration requirements under the Securities Act, your option will not expire until the earlier of the Expiration Date or until it has been exercisable for an aggregate period of three months (which need not be consecutive) after the termination of your Continuous Service; provided further, if during any part of such three month period, the sale of any Common Stock received upon exercise of your option would violate the Companys insider trading policy, then your option will not expire until the earlier of the Expiration Date or until it has been exercisable for an aggregate period of three months (which need not be consecutive) after the termination of your Continuous Service during which the sale of the Common Stock received upon exercise of your option would not be in violation of the Companys insider trading policy;
(c) twelve months after the termination of your Continuous Service due to your Disability, except as otherwise provided in Sections 6(d) and 6(e) below;
(d) eighteen months after your death if you die either (i) during your Continuous Service, (ii) within three months after the termination of your Continuous Service for any reason other than Cause or your Disability, or (iii) within twelve months after the termination of your Continuous Service due to your Disability, in each case except as otherwise provided in Section 6(e) below;
3.
(e) if your Qualifying Termination occurs prior to the effective date of a Change in Control, the later of the following (the Qualifying Termination Period): (i) the period determined under Section 6(b), 6(c) or 6(d) above, as applicable, or (ii) one month after the effective date of the Change in Control; provided, however, that if the Qualifying Termination Period is the one-month period after the effective date of the Change in Control and you die during such Qualifying Termination Period, such Qualifying Termination Period will be extended until eighteen months after your death; or
(f) the Expiration Date indicated in your Grant Notice.
7. EXERCISE. You may exercise the vested portion of your option during its term by (i) delivering a Notice of Exercise (in a form designated by the Company) or making the required electronic election with the Companys designated broker, and (ii) paying the exercise price and any applicable withholding taxes to the Companys Secretary, stock plan administrator, or such other person as the Company may designate, together with any additional documents as the Company may then require.
8. TRANSFERABILITY OF OPTION. Except as otherwise provided in this Section 8, your option is not transferable except by will or by the laws of descent and distribution, and is exercisable during your life only by you.
(a) Domestic Relations Orders. Upon receiving written permission from the Board or its duly authorized designee, and provided that you and the designated transferee enter into transfer and other agreements required by the Company, you may transfer your option pursuant to the terms of a domestic relations order, official marital settlement agreement or other divorce or separation instrument that contains the information required by the Company to effectuate the transfer. You are encouraged to discuss the proposed terms of any division of this option with the Company prior to finalizing the domestic relations order or marital settlement agreement to help ensure the required information is contained within the domestic relations order or marital settlement agreement.
(b) Beneficiary Designation. Upon receiving written permission from the Board or its duly authorized designee, you may, by delivering written notice to the Company in a form approved by the Company and any broker designated by the Company to handle option exercises, designate a third party who, after your death, will be entitled to exercise the option and receive the Common Stock or other consideration resulting from the exercise. In the absence of such a designation, in the event of your death, your executor or administrator of your estate will be entitled to exercise the option and receive, on behalf of your estate, the Common Stock or other consideration resulting from such exercise.
9. OPTION NOT A SERVICE CONTRACT. Your option is not an employment or service contract, and nothing in your option will be deemed to create in any way whatsoever any obligation on your part to continue in the service of the Company or an Affiliate, or of the Company or an Affiliate to continue your service. In addition, nothing in your option will obligate the Company or an Affiliate, their respective stockholders, boards of directors, officers or employees to continue any relationship that you might have as an Employee, Director or Consultant for the Company or an Affiliate.
10. WITHHOLDING OBLIGATIONS.
(a) At the time you exercise your option, in whole or in part, and at any time thereafter as requested by the Company, you hereby authorize withholding from payroll and any other amounts payable to you, and otherwise agree to make adequate provision for
4.
(including by means of a same day sale pursuant to a program developed under Regulation T as promulgated by the Federal Reserve Board), any sums required to satisfy the federal, state, local and foreign tax withholding obligations of the Company or an Affiliate, if any, which arise in connection with the exercise of your option.
(b) Upon your request and subject to approval by the Board or Committee, as applicable, and compliance with any applicable legal conditions or restrictions, the Company may withhold from fully vested shares of Common Stock otherwise issuable to you upon the exercise of your option a number of whole shares of Common Stock having a Fair Market Value, determined by the Company as of the date of exercise, not in excess of the maximum amount of tax required to be withheld by law (or such other amount as may be necessary to avoid classification of your option as a liability for financial accounting purposes). Any adverse consequences to you arising in connection with such share withholding procedure will be your sole responsibility.
(c) You may not exercise your option unless the tax withholding obligations of the Company and any Affiliate are satisfied. Accordingly, you may not be able to exercise your option when desired even though your option is vested, and the Company will have no obligation to issue a certificate for such shares of Common Stock or release such shares of Common Stock from any escrow provided for herein, if applicable, unless such obligations are satisfied.
11. TAX CONSEQUENCES. You hereby agree that the Company does not have a duty to design or administer the Plan or its other compensation programs in a manner that minimizes your tax liabilities. You will not make any claim against the Company, or any of its Officers, Directors, Employees or Affiliates related to tax liabilities arising from your option or your other compensation. In particular, you acknowledge that this option is exempt from Section 409A of the Code only if the exercise price per share specified in the Grant Notice is at least equal to the fair market value per share of the Common Stock on the Date of Grant and there is no other impermissible deferral of compensation associated with the option.
12. NOTICES. Any notices provided for in your option or the Plan will be given in writing (including electronically) and will be deemed effectively given upon receipt or, in the case of notices delivered by mail by the Company to you, five days after deposit in the U.S. mail, postage prepaid, addressed to you at the last address you provided to the Company. The Company may, in its sole discretion, decide to deliver any documents related to participation in the Plan and this option by electronic means or to request your consent to participate in the Plan by electronic means. By accepting this option, you consent to receive such documents by electronic delivery and to participate in the Plan through an online or electronic system established and maintained by the Company or another third party designated by the Company.
13. GOVERNING PLAN DOCUMENT. Your option is subject to all the terms of the Plan, which are hereby made a part of your option, and is further subject to all interpretations, amendments, rules and regulations, which may from time to time be promulgated and adopted pursuant to the Plan. In addition, your option (and any compensation paid or shares issued under your option) is subject to recoupment in accordance with The DoddFrank Wall Street Reform and Consumer Protection Act and any implementing regulations thereunder, any clawback policy adopted by the Company and any compensation recovery policy otherwise required by applicable law. No recovery of compensation under such a clawback policy will be an event giving rise to a right to resign for good reason or for a constructive termination (or similar term) under any agreement with the Company.
5.
14. EFFECT ON OTHER EMPLOYEE BENEFIT PLANS. The value of your option will not be included as compensation, earnings, salaries, or other similar terms used when calculating your benefits under any employee benefit plan sponsored by the Company or any Affiliate, except as such plan otherwise expressly provides. The Company expressly reserves its rights to amend, modify, or terminate any of the Companys or any Affiliates employee benefit plans.
15. VOTING RIGHTS. You will not have voting or any other rights as a stockholder of the Company with respect to the shares to be issued pursuant to your option until such shares are issued to you. Upon such issuance, you will obtain full voting and other rights as a stockholder of the Company. Nothing contained in your option, and no action taken pursuant to its provisions, will create or be construed to create a trust of any kind or a fiduciary relationship between you and the Company or any other person.
16. SEVERABILITY. If all or any part of this Option Agreement or the Plan is declared by any court or governmental authority to be unlawful or invalid, such unlawfulness or invalidity will not invalidate any portion of this Option Agreement or the Plan not declared to be unlawful or invalid. Any Section of this Option Agreement (or part of such a Section) so declared to be unlawful or invalid shall, if possible, be construed in a manner which will give effect to the terms of such Section or part of a Section to the fullest extent possible while remaining lawful and valid.
17. MISCELLANEOUS.
(a) The rights and obligations of the Company under your option will be transferable to any one or more persons or entities, and all covenants and agreements hereunder will inure to the benefit of, and be enforceable by the Companys successors and assigns.
(b) You agree upon request to execute any further documents or instruments necessary or desirable in the sole determination of the Company to carry out the purposes or intent of your option.
(c) This Option Agreement will be subject to all applicable laws, rules, and regulations, and to such approvals by any governmental agencies or national securities exchanges as may be required.
* * *
This Option Agreement will be deemed to be signed by you upon the signing by you of the Option Grant Notice to which it is attached.
6.
ATTACHMENT
INTRA-CELLULAR THERAPIES, INC.
2019 INDUCEMENT AWARD PLAN
[ATTACH A COPY OF THE PLAN WHEN DISTRIBUTING TO OPTIONHOLDERS]
Exhibit 23.1
Consent of Independent Registered Public Accounting Firm
We consent to the incorporation by reference in the following Registration Statements:
(1) Registration Statement (Form S-3 No. 333-235817) of Intra-Cellular Therapies, Inc.,
(2) Registration Statement (Form S-3 No. 333-233537) of Intra-Cellular Therapies, Inc.,
(3) Registration Statement (Form S-8 No. 333-225799) pertaining to the Intra-Cellular Therapies, Inc. 2018 Equity Incentive Plan of Intra-Cellular Therapies, Inc.,
(4) Registration Statement (Form S-8 No. 333-205070) pertaining to the Intra-Cellular Therapies, Inc. Amended and Restated 2013 Equity Incentive Plan of Intra-Cellular Therapies, Inc.,
(5) Registration Statement (Post-Effective Amendment No. 3 to Form S-1 on Form S-3 No. 333-191238) of Intra-Cellular Therapies, Inc., and
(6) Registration Statement (Form S-8 No. 333-193310) pertaining to the ITI, Inc. 2003 Equity Incentive Plan, as amended, and the Intra-Cellular Therapies, Inc. 2013 Equity Incentive Plan of Intra-Cellular Therapies, Inc.;
of our reports dated March 2, 2020, with respect to the consolidated financial statements of Intra-Cellular Therapies, Inc. and the effectiveness of internal control over financial reporting of Intra-Cellular Therapies, Inc. included in this Annual Report (Form 10-K) of Intra-Cellular Therapies, Inc. for the year ended December 31, 2019.
/s/ Ernst & Young LLP
Baltimore, Maryland
March 2, 2020
Exhibit 31.1
CERTIFICATIONS UNDER SECTION 302
I, Sharon Mates, Ph.D., certify that:
1. I have reviewed this annual report on Form 10-K of Intra-Cellular Therapies, Inc.;
2. Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this report;
3. Based on my knowledge, the financial statements, and other financial information included in this report, fairly present in all material respects the financial condition, results of operations and cash flows of the registrant as of, and for, the periods presented in this report;
4. The registrants other certifying officer(s) and I are responsible for establishing and maintaining disclosure controls and procedures (as defined in Exchange Act Rules 13a-15(e) and 15d-15(e)) and internal control over financial reporting (as defined in Exchange Act Rules 13a-15(f) and 15d-15(f)) for the registrant and have:
a) Designed such disclosure controls and procedures, or caused such disclosure controls and procedures to be designed under our supervision, to ensure that material information relating to the registrant, including its consolidated subsidiaries, is made known to us by others within those entities, particularly during the period in which this report is being prepared;
b) Designed such internal control over financial reporting, or caused such internal control over financial reporting to be designed under our supervision, to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external purposes in accordance with generally accepted accounting principles;
c) Evaluated the effectiveness of the registrants disclosure controls and procedures and presented in this report our conclusions about the effectiveness of the disclosure controls and procedures, as of the end of the period covered by this report based on such evaluation; and
d) Disclosed in this report any change in the registrants internal control over financial reporting that occurred during the registrants most recent fiscal quarter (the registrants fourth fiscal quarter in the case of an annual report) that has materially affected, or is reasonably likely to materially affect, the registrants internal control over financial reporting; and
5. The registrants other certifying officer(s) and I have disclosed, based on our most recent evaluation of internal control over financial reporting, to the registrants auditors and the audit committee of the registrants board of directors (or persons performing the equivalent functions):
a) All significant deficiencies and material weaknesses in the design or operation of internal control over financial reporting which are reasonably likely to adversely affect the registrants ability to record, process, summarize and report financial information; and
b) Any fraud, whether or not material, that involves management or other employees who have a significant role in the registrants internal control over financial reporting.
Date: March 2, 2020
/s/ Sharon Mates, Ph.D. |
Sharon Mates, Ph.D. |
Chairman, President and Chief Executive Officer (principal executive officer) |
Exhibit 31.2
CERTIFICATIONS UNDER SECTION 302
I, Lawrence J. Hineline, certify that:
1. I have reviewed this annual report on Form 10-K of Intra-Cellular Therapies, Inc.;
2. Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this report;
3. Based on my knowledge, the financial statements, and other financial information included in this report, fairly present in all material respects the financial condition, results of operations and cash flows of the registrant as of, and for, the periods presented in this report;
4. The registrants other certifying officer(s) and I are responsible for establishing and maintaining disclosure controls and procedures (as defined in Exchange Act Rules 13a-15(e) and 15d-15(e)) and internal control over financial reporting (as defined in Exchange Act Rules 13a-15(f) and 15d-15(f)) for the registrant and have:
a) Designed such disclosure controls and procedures, or caused such disclosure controls and procedures to be designed under our supervision, to ensure that material information relating to the registrant, including its consolidated subsidiaries, is made known to us by others within those entities, particularly during the period in which this report is being prepared;
b) Designed such internal control over financial reporting, or caused such internal control over financial reporting to be designed under our supervision, to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external purposes in accordance with generally accepted accounting principles;
c) Evaluated the effectiveness of the registrants disclosure controls and procedures and presented in this report our conclusions about the effectiveness of the disclosure controls and procedures, as of the end of the period covered by this report based on such evaluation; and
d) Disclosed in this report any change in the registrants internal control over financial reporting that occurred during the registrants most recent fiscal quarter (the registrants fourth fiscal quarter in the case of an annual report) that has materially affected, or is reasonably likely to materially affect, the registrants internal control over financial reporting; and
5. The registrants other certifying officer(s) and I have disclosed, based on our most recent evaluation of internal control over financial reporting, to the registrants auditors and the audit committee of the registrants board of directors (or persons performing the equivalent functions):
a) All significant deficiencies and material weaknesses in the design or operation of internal control over financial reporting which are reasonably likely to adversely affect the registrants ability to record, process, summarize and report financial information; and
b) Any fraud, whether or not material, that involves management or other employees who have a significant role in the registrants internal control over financial reporting.
Date: March 2, 2020
/s/ Lawrence J. Hineline |
Lawrence J. Hineline |
Senior Vice President of Finance and Chief Financial Officer (principal financial officer and principal accounting officer) |
Exhibit 32.1
CERTIFICATIONS UNDER SECTION 906
Pursuant to section 906 of the Sarbanes-Oxley Act of 2002 (subsections (a) and (b) of section 1350, chapter 63 of title 18, United States Code), each of the undersigned officers of Intra-Cellular Therapies, Inc., a Delaware corporation (the Company), does hereby certify, to such officers knowledge, that:
The Annual Report for the year ended December 31, 2019 (the Form 10-K) of the Company fully complies with the requirements of Section 13(a) or 15(d) of the Securities Exchange Act of 1934, and the information contained in the Form 10-K fairly presents, in all material respects, the financial condition and results of operations of the Company.
Dated: March 2, 2020 |
/s/ Sharon Mates, Ph.D. |
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Sharon Mates, Ph.D. | ||||
Chairman, President and Chief Executive Officer (principal executive officer) |
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Dated: March 2, 2020 |
/s/ Lawrence J. Hineline |
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Lawrence J. Hineline | ||||
Senior Vice President of Finance and Chief Financial Officer (principal financial officer and principal accounting officer) |