UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

WASHINGTON, D.C. 20549

 

 

FORM 8-K

 

 

CURRENT REPORT

Pursuant to Section 13 or 15(d)

of the Securities Exchange Act of 1934

Date of Report (Date of earliest event reported): October 24, 2020

 

 

Aileron Therapeutics, Inc.

(Exact Name of Company as Specified in Charter)

 

 

 

Delaware   001-38130   13-4196017

(State or Other Jurisdiction

of Incorporation)

 

(Commission

File Number)

 

(IRS Employer

Identification No.)

 

490 Arsenal Way

Watertown, MA

  02472
(Address of Principal Executive Offices)   (Zip Code)

Registrant’s telephone number, including area code: (617) 995-0900

Not applicable

(Former Name or Former Address, if Changed Since Last Report)

 

 

Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions (see General Instruction A.2. below):

 

☐

Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)

 

☐

Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)

 

☐

Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))

 

☐

Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))

Securities registered pursuant to Section 12(b) of the Act:

 

Title of each class

 

Trading

Symbol

 

Name of each exchange

on which registered

Common Stock, $0.001 par value per share   ALRN   Nasdaq Capital Market

Indicate by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 (§230.405 of this chapter) or Rule 12b-2 of the Securities Exchange Act of 1934 (§240.12b-2 of this chapter).

Emerging growth company  ☒

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act.  ☒

 

 

 

Item 7.01

Regulation FD Disclosure.

On October 24, 2020, a poster titled Prevention of Chemotherapy-induced Myelosuppression in SCLC Patients Treated with the Dual MDMX/MDM2 Inhibitor ALRN-6924, which was submitted by Aileron Therapeutics, Inc. (the “Company”) for the 32nd EORTC-NCI-AACR Annual Symposium on Molecular Targets and Cancer Therapeutics (“ENA 2020”), was published on the ENA 2020 website (event.eortc.org/ena2020). A copy of the poster is attached as Exhibit 99.1 to this Current Report on Form 8-K and is incorporated herein by reference.

The information in this Item 7.01, including Exhibit 99.1 attached hereto, is furnished under Item 7.01 of Form 8-K, and shall not be deemed “filed” for purposes of Section 18 of the Securities Exchange Act of 1934 (the “Exchange Act”) or otherwise subject to the liabilities of that section, nor shall it be deemed incorporated by reference in any filing under the Securities Act of 1933 or the Exchange Act, except as expressly set forth by specific reference in such a filing.

 

Item 8.01

Other Events.

On October 24, 2020, the Company announced positive clinical data from its ongoing Phase 1b trial of ALRN-6924 demonstrating clinical proof of concept that treatment with ALRN-6924 prior to second-line topotecan administration resulted in a protective effect against severe anemia, thrombocytopenia and neutropenia in patients with p53-mutated small cell lung cancer (“SCLC”). The results were presented at ENA 2020.

As of August 31, 2020, the data cut-off date, a total of 26 adult patients were enrolled in the dose optimization part of the Phase 1b trial. Of these patients, 18 patients were enrolled across three ALRN-6924 dose levels (0.3 mg/kg, 0.6 mg/kg and 1.2 mg/kg) and eight patients were enrolled in a 0.3 mg/kg expansion cohort. 25 of the 26 total enrolled patients had completed the first treatment cycle and therefore met protocol-defined criteria for evaluability as of the August 31, 2020 data cut-off date. In this part of the trial, ALRN-6924 was administered 24 hours before each dose of topotecan. Topotecan (1.5 mg/m2) was administered on days 1 through 5 of every 21-day treatment cycle. In the trial, toxicities were evaluated using the National Cancer Institute’s (“NCI”) Common Terminology Criteria for Adverse Events (“CTCAE”). Per the Phase 1b trial protocol, patients were not permitted to receive prophylactic granulocyte-colony stimulating factor (“G-CSF”) treatment in cycle 1.

Key findings from data analysis include the following:

 

  •  

A protective effect against severe chemotherapy-induced toxicities was observed across all ALRN-6924 dose levels as compared to third party historical controls.

 

  •  

Across all ALRN-6924 dose levels, Grade 3/4 anemia, Grade 3/4 thrombocytopenia and Grade 4 neutropenia (defined as <500/µL) were limited to 24%, 36% and 48% of patients, respectively.

 

  •  

While chemoprotection effects were observed across all ALRN-6924 dose levels, the 0.3 mg/kg dose level showed the most robust chemoprotection results, with Grade 3/4 anemia, Grade 3/4 thrombocytopenia and Grade 4 neutropenia limited to 21%, 36% and 43% of patients, respectively.

 

  •  

None of the patients treated at 0.3 mg/kg dose level had hematological serious adverse events. One patient treated at 0.3 mg/kg dose level required one red blood cell transfusion and one platelet transfusion.

 

  •  

At the 0.3 mg/kg ALRN-6924 dose level, no patients required erythropoiesis-stimulating agents, and seven patients (50%) required G-CSF treatment.

 

  •  

Across all ALRN-6924 dose levels, no patients experienced febrile neutropenia which is a severe toxicity commonly observed with topotecan treatment in this patient population.

The key hematological toxicities from the Phase 1b dose optimization part of the trial as of the data cut-date of August 31, 2020 are shown in the table below. Four of the evaluable patients remained on treatment in the trial as of the data cut-off date.

 

     ALRN-6924 0.3 mg/kg +
Topotecan 1.5 mg/m2 		  ALRN-6924 (all dose levels) +
Topotecan 1.5 mg/m2

Adverse Events*

NCI CTCAE Grade ³3

  

N(%)

N=14

 

N(%)

N=25

All AEs    13 (93)   24 (96)
Anemia    3 (21)   6 (24)
Thrombocytopenia    5 (36)   9 (36)
Neutropenia    11 (79)   22 (88)
Febrile Neutropenia    0 (0)   0 (0)

Neutropenia

NCI CTCAE Grade 4**

   6 (43)**   12 (48)**

 

*

AEs based on laboratory values (as applicable)

 

**

For the first treatment cycle and for all treatment cycles

Enrollment in the dose optimization part of the Phase 1b trial, in which (ALRN-6924 is administered 24 hours before each dose of topotecan), is complete, and monitoring is ongoing with four of the evaluable patients continuing treatment past the data cut-off date.

The Company continues to enroll patients in a schedule optimization part of the Phase 1b trial intended to determine whether ALRN-6924 given six hours prior to topotecan could be an alternative dosing schedule that could provide patients and healthcare providers with additional flexibility as to when to administer ALRN-6924 before topotecan. The Company plans to report the final data for the Phase 1b trial, including data from the 6 hour-schedule part, in the first quarter of 2021.

In the fourth quarter of 2020, the Company plans to initiate a study of ALRN-6924 in healthy volunteers to characterize the time to onset, and the magnitude and duration of cell cycle arrest in human bone marrow relative to ALRN-6924 administration. Subject to the results of the healthy volunteer study and the final data from the Phase 1b trial, the Company expects to initiate a clinical program in patients with non-small cell lung cancer beginning with a Phase 1b trial in the fourth quarter of 2021 and a development program in a gastrointestinal cancer indication at a later point in time. The Company does not currently plan to conduct additional development of ALRN-6924 in patients with SCLC.

Forward-Looking Statements

Statements in this report [and Exhibit 99.1] about Company’s future expectations, plans and prospects, as well as any other statements regarding matters that are not historical facts, may constitute forward-looking statements within the meaning of The Private Securities Litigation Reform Act of 1995. These statements include, but are not limited to, statements about the Company’s strategy and clinical development plans. The words “anticipate,” “believe,” “continue,” “could,” “estimate,” “expect,” “intend,” “may,” “plan,” “potential,” “predict,” “project,” “should,” “target,” “would” and similar expressions are intended to identify forward-looking statements, although not all forward-looking statements contain these identifying words. Actual results may differ materially from those indicated by such forward-looking statements as a result of various important factors, including whether the Company’s cash resources will be sufficient to fund its continuing operations for the periods and/or trials anticipated; whether the Company will obtain sufficient cash resources to conduct its planned clinical trials; whether results obtained in clinical trials will be indicative of results obtained in future clinical trials; whether third party data would be indicative of the data that would be obtained in a randomized, head-to-head clinical trial; whether the Company’s product candidates will advance through the clinical trial process on a timely basis, or at all; whether the results of such trials will be accepted by and warrant submission for approval from the United States Food and Drug Administration or equivalent foreign regulatory agencies; whether the Company’s product candidates will receive approval from regulatory agencies on a timely basis or at all; whether, if product candidates obtain approval, they will be successfully distributed and marketed; what impact the coronavirus pandemic may have on the timing of our clinical development, clinical supply and our operations; and other factors discussed in the “Risk Factors” section of the Company’s quarterly report on Form 10-Q for the period ended June 30, 2020, and risks described in other filings that the Company may make with the Securities and Exchange Commission. Any forward-looking statements contained in this report and Exhibit 99.1 speak only as of the date hereof, and the Company specifically disclaims any obligation to update any forward-looking statement, whether because of new information, future events or otherwise.

 

Item 9.01.

Financial Statements and Exhibits.

(d) Exhibits:

 

Exhibit No.

   Description
99.1    Poster titled “Prevention of Chemotherapy-induced Myelosuppression in SCLC PatientsTreated with the Dual MDMX/MDM2 Inhibitor ALRN-6924”

SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, as amended, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.

 

    Aileron Therapeutics, Inc.
Date: October 26, 2020     By:  

/s/ Richard J. Wanstall

      Richard J. Wanstall
      Chief Financial Officer and Treasurer
Exhibit 99.1
LOGO

Prevention of Chemotherapy-induced Myelosuppression in SCLC Patients Treated with the Dual MDMX/MDM2 Inhibitor ALRN-6924 Zoran Andric1, Timur Ceric2, Mirko Stanetic3, Milan Rancic4, Marko Jakopovic5, Santiago Ponce Aix6, Rodryg Ramlau7, Egbert Smit8, Malgorzata Ulanska9, Christopher Caldwell10, Dora Ferrari10, Allen Annis10, Vojislav Vukovic10, Bojan Zaric11 1CHC Bezanijska Kosa, Belgrade, Serbia, 2Clinical Center University of Sarajevo, Sarajevo, Bosnia and Herzegovina, 3University Clinical Center Lung Clinic, Banja Luka, Bosnia and Herzegovina, 4Clinic for Pulmonary Diseases, Clinical Center Nis, Serbia, 5Clinic for Lung Disease Jordanovac, Zagreb, Croatia, 6Hospital Universitario 12 de Octubre, Madrid, Spain, 7Poznan University of Medical Sciences, Poland, 8Stichting Het Nederlands Kanker Instituut – Antoni van Leeuwenhoek Ziekenhuis, Amsterdam, Netherlands, 9Centrum Terapii Współczesnej, Lodz, Poland, 10Aileron Therapeutics Inc., Watertown, MA, 11Institute for Pulmonary Diseases of Vojvodina, Faculty of Medicine, University of Novi Sad, Novi Sad, Serbia Abstract Table 3: TEAEs Occurring in 10% of All Patients ALL AEs ALL AEs GRADE 3 Figure 2: ALRN-6924 Plasma Pharmacokinetics Figure 3: Dose-response Between ALRN-6924 and Serum MIC-1, a Biomarker of p53 Activation Background: ALRN-6924 is a cell-permeating, stabilized alpha-helical peptide that binds with high affinity to endogenous p53 inhibitors MDM2 and MDMX. Treatment with ALRN-6924 increases intracellular p53 levels and initiates its transcriptional activity, leading to cell cycle arrest. This effect is limited to cells with wild-type, functional p53; therefore, for patients with tumors 0.3 mg/kg (N=14) N (%) 0.6 mg/kg (N=5) N (%) 1.2 mg/kg (N=6) N (%) Total (N=25) N (%) 0.3 mg/kg (N=14) N (%) 0.6 mg/kg (N=5) N (%) 1.2 mg/kg (N=6) N (%) Total (N=25) N (%) PARAMETER (AVERAGE) 0.3 mg/kg 0.6 mg/kg 1.2 mg/kg A 60 55 50 >ZE Ğ ŵ Ŭ harboring mutated P53, pre-treatment with ALRN-6924 may selectively induce cell cycle arrest in normal cells allowing chemotherapy to selectively target cancer cells that are actively cycling. Materials and Methods: A Phase 1b study in extensive disease small-cell lung cancer (ED SCLC) patients with ECOG PS 0-2 receiving topotecan was conducted to evaluate the ability of ALRN-6924 to reduce bone marrow toxicity without impacting the efficacy of topotecan. Inclusion criteria included the presence of p53 mutations in tumor tissue as measured by next-generation sequencing. Prophylactic use of growth factors was not permitted in the first treatment cycle. ALRN-6924 was given at three dose levels: 0.3, 0.6 and 1.2 mg/kg on days 0-4 of each treatment cycle. Topotecan was administered 24 hrs after ALRN-6924 on days 1-5 at 1.5 ALL AEs 14 (100) 5 (100) 6 (100) 25 (100) 13 (93) 5 (100) 6 (100) 24 (96) NEUTROPENIA 11 (79) 5 (100) 6 (100) 22 (88) 11 (79) 5 (100) 6 (100) 22 (88) THROMBOCYTOPENIA 9 (64) 4 (80) 5 (83) 18 (72) 5 (36) 2 (40) 2 (33) 9 (36) LEUKOPENIA 6 (43) 4 (80) 4 (67) 14 (56) 2 (14) 4 (80) 4 (66) 10 (40) ANEMIA 5 (36) 4 (80) 3 (50) 12 (48) 3 (21) 2 (40) 1 (17) 6 (24) FATIGUE 3 (21) 2 (40) 2 (33) 7 (28) 0 1 (20) 0 1 (4) FEVER 2 (14) 1 (20) 0 3 (12) 0 0 0 0 45 > 40 ŵ Cmax µg/mL 5.0 9.9 21.9 Ő 35 Ŷ 30 25 / 20 D AUC0-24hr ng·hr/mL 35,862 83,030 250,519 15 ŵ 10 Ğ ^ 5 0 t½ hr 3.4 4.5 7.1 0 5 10 15 20 25 30 35 40 45 50 55 60 mg/m2 of each treatment cycle. Hematological laboratory values were coded as AEs based on NCI CTC v5.0. Plasma and serum samples were analyzed for ALRN-6924 pharmacokinetics and pharmacodynamic biomarkers of p53 activation. Table 4: Historical Controls Trial Phase N* Cycles 100000 Hematological Toxicity Grade 3 (%) B Note: Data points <5 ng/mL at 24 hrs not shown Ž Ğ 70 65 60 55 dŝŵ ŌĞ >ZE Ž Ğ Ś >ZE Ž Ğ ŵ Ŭ Results: As of 31-August-2020, 26 patients were enrolled (6 per dose level and 8 additional patients in the expansion cohort); Median Comments > > 50 ŵ 10000 ŵ 45 Ő Ő 25/26 patients were evaluable. Baseline characteristics were typical for this patient population (median age 67 years, 80% males, ECOG PS 0 60%, baseline LDH ULN 40%, chemosensitive population 48%). Median number of completed topotecan treatment cycles was 3. 12% of patients required topotecan dose reduction. Disease control rate was 64%. No patients reported Grade 3 Neutropenia Febrile Neutropenia Hematological Toxicity Reported by Laboratory Values Thrombo cytopeniaAnemia Ŷ Ŷ Ž Ă Ŷ 1000 Ŷ / D 40 35 30 25 events of nausea, vomiting, diarrhea, and 1 patient had fatigue Grade 3. Grade 3/4 anemia, thrombocytopenia and neutropenia were reported in 24%, 36% and 88% of patients and compare favorably to recent historical results of Grade 3/4 anemia, thrombocytopenia and neutropenia of 63%, 70% and 86%.1 JCO, 20191 2 28 3 86 17 70 63 Chemosensitive population not reported; GCSF not Hart, et al. Ğ 100 D prophylactic in C; Transfusions: Plt 31%, RBC 41% Ŷ Ž Hematological Toxicity Reported as AEs 10 JCO, 20142 3 213 5 54 3 54 31 Chemosensitive population 55%; RBC transfusions 53%; Pawel, et al. 20 ŵ 15 Ğ 10 ^ 5 0 0 10 20 30 0 10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 The 0.3 mgkg ALRN-6924 dose level showed the most consistent chemoprotection results, with NCI CTC Grade 3/4 anemia, Mandatory prophylactic growth factors Time (hr) Dose Ž Ğ JCO, 20073 3 151 4 88 5 43 31 Chemosensitive population 100%; RBC transfusions43%; dŝŵ ŌĞ >ZE Ž Ğ Ś Eckardt, et al. thrombocytopenia and neutropenia limited to 21%, 37% and 79% of patients, respectively, and a 43% rate of neutropenia Grade 4 GCSF 16% • Monophasic clearance, low patient-to-patient variability • Slightly less than dose-proportional exposure A) Serum MIC-1 following a single ALRN-6924 dose. B) Serum MIC-1 following fivedaily in the 1st treatment cycle (historical result: 76%); none of the patients treated at this dose level had hematological SAEs nor did they require RBC/platelet transfusions (historical result: 41% and 36%, respectively). Figure 1: ALRN-6924 Phase 1b StudySchema JCO, 20114 2 26 2 78 9 61 30 Chemosensitive population 100%; Growth factors as Jotte, et al. necessary; Worst toxicities in cycle #1 Inoue, et al. JCO, 20085 2 30 2 87 3 40 30 Chemosensitive population 63%;GCSF not prophylactic Table 5: Key Toxicities Relative to Recent Hisorical Control with AE’s Graded by Objective Laboratory Values • 3.4 to 7.1 hr half-life yields no accumulation on repeated dosing Figure 4: Radiological Evaluation of Tumor Response 40 ALRN-6924 doses. Data modelled from this trial and other ALRN-6924 clinical studies.6 Dose Optimization 24h ALRN-6924 Before Topotecan 3 Dose Levels Tested 0.3 mg/kg Expansion Enrollment Completed Dose Optimization Part of Phase 1b/2 Clinical Trial of ALRN-6924 as a ChemoprotectionAgent Topotecan ± Trilaciclib in SCLC Patients‡ s n o is e L te 35 30 25 AEs* NCI CTC GRADE 3 AEs* NCICTC GRADE 3 g 20 r Schedule Optimization 6h ALRN-6924 Before Topotecan Test up to 2 Dose Levels Ongoing ALRN-6924 0.3 mg/kg+ Topotecan N (%) N=14 ALRN-6924 + Topotecan, All Patients N (%) N=25 Placebo + Topotecan N (%) N=28 Trilaciclib + Topotecan N (%) N=32 a T r o f e n il e s a B 15 10 5 0 Color by Best Overall Response Stable Disease WĂ ZĞ ŽŶ Ğ Anemia Thrombocytopenia Neutropenia Endpoints ALL AEs 13 (93) 24 (96) 27 (96) 28 (88) m -5 NEUTROPENIA 11 (79) 22 (88) 24 (86) 22 (69) o r f THROMBOCYTOPENIA 5 (37) 9 (36) 20 (70) 22 (68) -10 e g ANEMIA 3 (21) 6 (24) 18 (63) 10 (39) n -15 a FEBRILE NEUTROPENIA 0 0 5 (17) 2 (6) h Progression % NCI CTC Gr 3 Table 1: Demographics and Key Baseline Characteristics % NCI CTC Gr 3 % NCI CTC Gr 3 Table 2: Study Drug Exposure C -20 FATIGUE 0 0 2 (7) 3 (9) e g NAUSEA 0 0 1 (4) 0 a -25 t n e -30 c r NEUTROPENIA e NCI CTC GRADE 4** 6 (43) 12 (48) 21 (76) 13 (41) P -35 t s *AEs based on laboratory values, as applicable e 0.3 mg/kg N (%) N=14 0.6 mg/kg N (%) N=5 1.2 mg/kg N (%) N=6 Total N (%) N=25 0.3 mg/kg N=14 0.6 mg/kg N=5 1.2 mg/kg N=6 -40 ** in the first treatment cycle Hart et al. ASCO, 2019 – G1 Therapeutics; Phase 2 Clinical Trial B Total -45 N=25 AGE Median 68.5 67 58 67 GENDER Male 14 (100) 2 (40) 4 (67) 20 (80) ECOG PS 0 10 (71) 2 (40) 3 (50) 15 (60) 1 4 (29) 3 (60) 3 (50) 10 (40) BASELINE LDH ULN 5 (36) 3 (60) 2 (33) 10 (40) TIME SINCE DURATION OF EXPOSURE (DAYS) Mean 62 41 61 57 Median (Min, Max) 59 (6, 204) 27 (6, 90) 42 (27, 157) 55 (6, 204) NUMBER OF CYCLES COMPLETED Mean 3.2 2 3.3 3 Median (Min, Max) 3 (1, 6) 1 (1, 4) 2.5 (1, 8) 3 (1, 8) Table 6: Other Results Support Chemoprotection Signal with ALRN-6924 Treatment SAEs 0.3 mg/kg, N (%), N=14 Total, N (%), N=25 NEUTROPENIA 0 3 (12) LEUKOPENIA 0 1 (4) THROMBOCYTOPENIA 0 2 (8) ANEMIA 0 1 (4) ANGINA PECTORIS 1 (7) 1 (4) Disease control rate (DCR) was 64%. In independent trials of SCLC patients receiving second-line topotecan the DCR ranged from 4% to 62%.2-5 Conclusions This is the first clinical study to demonstrate a chemoprotective effect of p53 activation via selective induction of cell cycle arrest in normal cells. This novel strategy has the potential to benefit the >50% of all cancer patients with tumors harboring p53 mutations. References PREVIOUS THERAPY STAGE AT INITIAL TUMOR DIAGNOSIS P53 MUTATION <60 days 7 (50) 1 (20) 5 (83) 13 (52) Extensive Disease 6 (100) 5 (100) 6 (100) 25 (100) TOPOTECAN DOSE REDUCTIONS Patients with any dose reductions, N (%) 2 (14) 0 1 (17) 3 (12) ALRN-6924 DOSE REDUCTIONS Patients with any dose TRANSFUSIONS 0.3 mg/kg, N (%), N=14 Total, N (%), N=25 RBC TRANSFUSIONS 1 (7) 7 (28) PLATELET TRANSUSIONS 1 (7) 4 (16) PERFORMANCE STATUS 0.3 mg/kg, N=14 Total, N=25 ECOG PS AT BASELINE (Mean, Median) 0.3, 0 0.4, 0 ECOG FINAL PS (Mean, Median) 0.6, 0 0.8, 0 1.Hart L.L., et al. Effect of trilaciclib, a CDK 4/6 inhibitor, on myelosuppression in patients with previously treated extensive-stage small cell lung cancer receiving topotecan. J. Clin. Oncol. 37(15): 8505, 2019. 2.Pawel J., et al. Randomized phase III trial of amrubicin versus topotecan as second-line treatment for patients with small-cell lung cancer. J. Clinical Oncol. 32(35): 4012-4019, 2014. 3. Eckhardt J.R., et al. Phase III study of oral compared with intravenous topotecan as second-line therapy in small-cell lung cancer. J. Clin. Oncol. 25(15): 2086-2092, 2007. 4.Jotte R., et al. Randomized phase II trial of single-agent amrubicin or topotecan as second-line treatment in patients with small-cell lung cancer sensitive to first-line platinum-based chemotherapy. J. Clin. Oncol. 29(3): 287-293, 2011. 5.Inoue A., et al. Randomized phase II trial comparing amrubicin with topotecan in patients with previously treated small-cell lung cancer: North Japan Lung Cancer Study Group Trial 0402. J. Clin. Oncol. 26(33): 5401-5406, 2008. STATUS Mutated 13 (93) 5 (100) 6 (100) 24 (96) reductions, N (%) 0 0 0 0 Following abstract submission, one patient was determined to have received one RBC and one platelet transfusion 6.Meric-Bernstam F., et al. Phase I trial of a novel stapled peptide ALRN-6924 disrupting MDMX and MDM2-mediated inhibition of WTp53 in patients with solid tumors and lymphomas. J. Clin. Oncol. 35(15): 2505, 2017. 32nd 490 Arsenal Way - Watertown, MA 02472, USA | Phone: 617-995-0900 | info@aileronrx.com EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics: October 24 – October 25, 2020 | Virtual Symposium Online