As filed with the Securities and Exchange Commission on February 14, 2012
 
REGISTRATION NO. 333-_________
 
UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
WASHINGTON, D.C. 20549

FORM S-1

REGISTRATION STATEMENT

UNDER THE SECURITIES ACT OF 1933

CALDERA PHARMACEUTICALS, INC.
(Exact name of registrant as specified in its charter)
 
Delaware
 
3826
 
20-0982060
(State or jurisdiction of incorporation or organization)
 
(Primary Standard Industrial Classification Code Number)
 
(I.R.S. Employer Identification No.)

278 DP Road, Suite D
Los Alamos, New Mexico 87544
(505) 661-2420
(Address and telephone number of principal executive offices and principal place of business)

Hank Gracin, Esq.
Leslie Marlow, Esq.
Gracin & Marlow, LLP
405 Lexington Avenue, 26 th Floor
New York, New York 10174
Telephone (212) 907-6457
(Name, address and telephone number of agent for service)

Approximate Date of Proposed Sale to the Public: From time to time after the date this registration statement becomes effective.
 
If any of the securities being registered on this Form are to be offered on a delayed or continuous basis pursuant to Rule 415 under the Securities Act of 1933, check the following box. x

If this Form is filed to register additional securities for an offering pursuant to Rule 462(b) under the Securities Act, check the following box and list the Securities Act registration statement number of the earlier effective registration statement for the same offering.
 
If this Form is a post-effective amendment filed pursuant to Rule 462(c) under the Securities Act, check the following box and list the Securities Act registration statement number of the earlier effective registration statement for the same offering. o
  
If delivery of the prospectus is expected to be made pursuant to Rule 424, check the following box. o

Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, or a smaller reporting company.  See the definitions of “large accelerated filer,” “accelerated filer” and “smaller reporting company” in Rule 12b-2 of the Exchange Act.
 
 Large accelerated filer
o
Accelerated filer
o
Non-accelerated filer
o
Smaller reporting company
x
(Do not check if a smaller reporting company)
   
 

 
CALCULATION OF REGISTRATION FEE
 
Title of Each Class of Securities to be Registered
 
 
Amount to be
Registered (1)
   
Proposed Maximum Offering Price Per Share  (2)
   
Proposed Maximum Aggregate Offering Price
   
Amount of Registration Fee
 
Shares of common stock, par value $0.001
   
765,120
   
$
$5.00
   
$
3,825,600
   
$
438.42
 
Shares of common stock, par value $0.001 to be issued upon the exercise of outstanding warrants and convertible preferred stock
   
633,144
   
$
$5.00
   
$
3,165,750
   
$
362.79
 
Total shares being registered
   
1,398,264
           
$
6,991,350
   
$
801.21
 
 
(1) In accordance with Rule 416(a), the registrant is also registering hereunder an indeterminate number of shares that may be issued and resold resulting from stock splits, stock dividends or similar transactions.
 
(2) Estimated in accordance with Rule 457(c) of the Securities Act of 1933 solely for the purpose of computing the amount of the registration fee based on the recent sales of unregistered securities on February 13, 2012.
 
(3) Calculated under Section 6(b) of the Securities Act of 1933 as .00011460 of the aggregate offering price.
 
The registrant hereby amends this registration statement on such date or dates as may be necessary to delay its effective date until the registrant shall file a further amendment which specifically states that this registration statement shall thereafter become effective in accordance with Section 8(a) of the Securities Act of 1933 or until the registration statement shall become effective on such date as the Commission, acting pursuant to said Section 8(a), may determine.

 
THE INFORMATION CONTAINED IN THIS PROSPECTUS IS NOT COMPLETE AND MAY BE CHANGED. THESE SECURITIES MAY NOT BE SOLD UNTIL THE REGISTRATION STATEMENT FILED WITH THE SECURITIES AND EXCHANGE COMMISSION IS DECLARED EFFECTIVE. THIS PROSPECTUS IS NOT AN OFFER TO SELL THESE SECURITIES AND IT IS NOT SOLICITING AN OFFER TO BUY THESE SECURITIES IN ANY STATE WHERE THE OFFER OR SALE IS NOT PERMITTED.

SUBJECT TO COMPLETION, DATED FEBRUARY 14, 2012
 
PRELIMINARY PROSPECTUS
 
CALDERA PHARMACEUTICALS, INC.
 
1,398,264 SHARES OF COMMON STOCK
 
This prospectus relates to the resale and other disposition from time to time of up to 1,398,264 shares of our common stock by the selling stockholders identified under the section entitled “Selling Stockholders” on page 27. The shares of common stock offered consist of: (i) 765,120 shares of our common stock and (ii) 633,144 shares of our common stock issuable upon exercise of outstanding warrants to purchase common stock or conversion of Series A preferred shares into common stock. We issued all of the issued securities described above in private placement transactions completed prior to the filing of this registration statement.
 
The shares included in this prospectus may be reoffered and sold directly by the selling shareholders in accordance with one or more of the methods described in the plan of distribution, which begins on page 31 of this prospectus. We are not selling any shares of our common stock in this offering and therefore we will not receive any proceeds from the sales by the selling stockholders. Instead the shares may be offered and sold from time to time by the selling shareholders at a fixed price of $5.00 per share until the shares are quoted, if ever, on the OTC Bulletin Board or another exchange and thereafter at prevailing market prices or privately negotiated prices. We may receive proceeds from any exercise of outstanding warrants if and when such warrants are exercised for cash.
 
Our common stock does not presently trade on any exchange or electronic medium. Although we hope to be quoted on the OTC Bulletin Board, which is maintained by NASDAQ, no assurance can be given that our common stock will be quoted on the OTC Bulletin Board or any other quotation service.
 
Investing in the Company’s securities involves a high degree of risk. You should carefully consider the risks and uncertainties described under the heading “Risk Factors” which begin on page 7 of this prospectus before making a decision whether to purchase our common stock.

Neither the Securities and Exchange Commission nor any state securities commission has approved or disapproved of these securities or determined if this prospectus is truthful or complete. Any representation to the contrary is a criminal offense.

The date of this prospectus is ____________, 2012.
 

 
 
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II-1
 
 
You should rely only on the information that we have provided in this prospectus. We have not authorized anyone to provide you with different information and you must not rely on any unauthorized information or representation. We are not making an offer to sell these securities in any jurisdiction where an offer or sale is not permitted. This document may only be used where it is legal to sell these securities. You should assume that the information appearing in this prospectus is accurate only as of the date on the front of this prospectus, regardless of the time of delivery of this prospectus, or any sale of our common stock. Our business, financial condition and results of operations may have changed since the date on the front of this prospectus. We urge you to carefully read this prospectus before deciding whether to invest in any of the common stock being offered.
 
PROSPEC TUS SUMMARY
 
The following summary highlights material contained in this prospectus. This summary does not contain all the information you should consider before investing in our securities. Before making an investment decision, you should read the entire prospectus carefully, including the "Risk Factors" section, the financial statements and the notes to the financial statements that appear elsewhere in this prospectus.

Business Overview

Our Company, Caldera Pharmaceuticals, Inc. (“Caldera,” “Company,” Our”, “we”), is a research and development company engaged in various aspects of drug discovery. The cornerstone of our business is our unique technology based on direct chemical analysis of protein-drug combinations by means of micro X-ray fluorescence spectroscopy. We currently offer our customers analytical services using our technology to evaluate drug candidates for safety and efficacy. We believe that our technology can reduce the cost of drug discovery by detecting safety and efficacy issues at an early stage of development.  To date, substantially all of our revenue has been derived from our analytical services that we have performed for United States governmental agencies.  However, we expect that our future revenue will be derived from three lines of business: (i) provision of our analytical drug discovery services to both the government sector and private sector; (ii) sale or lease of new drug candidates that we may identify using the XRpro® drug discovery instruments that we are currently developing and commercialization; and (iii) sale of our drug discovery instruments. We intend to expand our customer base by offering our analytical services to biotechnical and pharmaceutical customers in addition to the government sector.  In an effort to increase revenue, we are currently developing  stand- alone units, our XRpro® drug discovery instruments, that can be licensed or sold to customers to allow them to use our technology to conduct the same analytical services that we provide.  We also anticipate deriving revenue from the development of drugs that are presented to us when conducting our chemical analysis.
 
We were incorporated in the State of Delaware on November 12, 2003.  On March 14, 2011, the Company filed a First Amended and Restated Certificate of Incorporation with the Secretary of State of Delaware increasing the authorized common shares from 10,000,000 to 50,000,000 and the issuance of up to 10,000,000 preferred shares. Subsequently, we filed a Certificate of Designations on March 14, 2011, which designated all of our 10,000,000 shares of preferred stock as Series A preferred stock.   The Company has reserved up to 3,000,000 shares for issuance to employees, directors and others in accordance with the terms of our 2005 Stock Option Plan.
 
Our principal executive offices are located at 278 DP Road Suite D Los Alamos, New Mexico 87544 our telephone number is (505) 661-2420.  We maintain a corporate website at www.cpsci.com .  Information found on our website is not part of this prospectus.

 
 
The Offering

     
Shares of our common stock offered for re-sale by the selling stockholders pursuant to this prospectus
 
1,398,264
     
Common stock currently outstanding
 
4,291,620
   
 
Proceeds to the Company
 
We will not receive any proceeds from the resale or other disposition of the shares covered by this prospectus by any selling shareholder.  We will receive net proceeds from the exercise of the warrants to purchase shares of our common stock covered by this prospectus which would total $1,834,460 if all the warrants were exercised for cash payment.
     
Risk Factors
 
There are significant risks involved in investing in our Company.  For a discussion of risk factors you should consider before buying our common stock see “Risk Factors” beginning on page 7

 
RISK FA CT ORS
 
Investment in our common stock involves a high degree of risk. You should carefully consider the risks described below together with all of the other information included herein before making an investment decision.  If any of the following risks actually occur, our business, financial condition or results of operations could suffer. In that case, the market price of our common stock could decline, and you may lose all or part of your investment.  

RISKS RELATED TO OUR BUSINESS

We have a history of losses and there can be no assurance that we will generate or sustain positive earnings.

For the years ended December 31, 2010 and December 31, 2009, we had a net loss of ($864,881) and ($144,549), respectively, and for the nine months ended September 30, 2011 and September 30, 2010, we had a net loss of ($1,358,791) and ($683,613), respectively.  We cannot be certain that our business strategy will ever be successful. Our likelihood of success must be considered in light of the problems, expenses, difficulties, complications and delays frequently encountered in connection with any emerging business operations. If we fail to address any of these risks or difficulties adequately, our business will likely suffer. Future revenues and profits, if any, will depend upon various factors, including the success, if any, of our expansion plans, marketability of our instruments and services, our ability to maintain favorable relations with manufacturers and customers, and general economic conditions. There is no assurance that we can operate profitably or that we will successfully implement our plans. There can be no assurance that we will ever generate positive earnings.

Substantially all of our net revenue has been generated from services provided to governmental agencies.  If such agencies were to no longer use our services, our net revenue and results of operations would be adversely affected.
 
To date we have derived substantially all of our revenue from services we performed for two governmental agencies.  For the year ended December 31, 2010 all of our revenue was derived from nine (9) different research projects for two governmental agencies and for the year ended December 31, 2009 all of our revenue was derived from ten (10) different research projects for the same two governmental agencies.  For the nine months ended September 30, 2011 ninety six percent (96%) of our revenue was derived from six (6) different research projects for the same two governmental agencies and for the nine months ended September 30, 2010 all of our revenue was derived from nine (9) different research projects for the same two governmental agencies. If there were to be a decline in the demand for our services from governmental agencies,  or the two governmental agencies from which we have received funding were required to reduce spending, our net revenue would be significantly impacted, which would negatively affect our business, financial condition and results of operations and may affect our ability to continue operations.

If we cannot establish profitable operations, we will need to raise additional capital to continue our operations, which may not be available on commercially reasonable terms, or at all, and which may dilute your investment.

We incurred a net loss for the year ended December 31, 2010 of ($864,881). Achieving and sustaining profitability will require us to increase our revenues and manage our product, operating and administrative expenses. We cannot guarantee that we will be successful in achieving profitability. If we are unable to generate sufficient revenues to pay our expenses and our existing sources of cash and cash flows are otherwise insufficient to fund our activities, we will need to raise additional funds to continue our operations. Other than our $750,000 funding facility, we do not have any arrangements in place for additional funds. If needed, additional funds may not be available on favorable terms, or at all. Furthermore, if we issue equity or debt securities to raise additional funds, our existing stockholders may experience dilution, and the new equity or debt securities may have rights, preferences and privileges senior to those of our existing stockholders. If we are unsuccessful in achieving profitability and we cannot obtain additional funds on commercially reasonable terms or at all, we may be required to curtail significantly or cease our operations, which could result in the loss of all of your investment in our stock.

Our financial statements had been prepared assuming that the Company will continue as a going concern.
 
We have generated losses to date and have limited working capital. We incurred a net loss of ($864,881) and ($144,549) for the years ended December 31, 2010 and 2009, respectively. At December 31, 2010 we had an accumulated deficit of ($3,659,878) and a working capital deficiency of ($224,771). These factors raise substantial doubt about our ability to continue as a going concern. Our financial statements do not include any adjustments that might result from this uncertainty. The report of our independent registered public accounting firm for the years ended December 31, 2010 and 2009 when originally issued included an explanatory paragraph expressing substantial doubt about our ability to continue as a going concern in their audit report included herein. If we cannot generate the required revenues and gross margin to achieve profitability or obtain additional capital on acceptable terms, we will need to substantially revise our business plan or cease operations and an investor could suffer the loss of a significant portion or all of his investment in our Company.
 
We may not receive the benefit of the use of our net operating loss carryforward.

Although our financial statements reflect a net operating loss carryforward, we may not receive benefit of its use.  Internal Revenue Code Section 382, and similar state rules, place a limitation on the amount of taxable income that can be offset by carry-forwards after a change in control (generally greater than a 50% change in ownership.

There is uncertainty as to market acceptance of our technology and products.

Until recently, our business has been solely dependent upon revenue derived from government agencies for services performed by us. We have not yet sold our XRpro® instruments to third parties nor have any drug candidates been commercialized from our technology. There can be no assurance that our XRpro® instruments will be accepted in the market or that our commercialization efforts will be successful.
 
The life sciences research instrumentation market is characterized by rapid technological change and frequent new product introductions. Our future success may depend on our ability to enhance our current products and to develop and introduce, on a timely basis, new products that address the evolving needs of our customers. We may experience difficulties or delays in our development efforts with respect to new products and the provision of our services, and we may not ultimately be successful in developing or commercializing them, which would harm our business. Any significant delay in releasing products or providing services could cause our revenues to suffer, adversely affect our reputation, give a competitor a first-to-market advantage or cause a competitor to achieve greater market share. In addition, our future success depends on our continued ability to develop new applications for our existing products and continuing to provide our current services. If we are not able to complete the development of these applications, or if we experience difficulties or delays, we may lose our current customers and may not be able to attract new customers, which could seriously harm our business and our future growth prospects.
 
We rely heavily on a single source for a major part of our product, and the partial or complete loss of this supplier could cause customer supply or production delays and a substantial loss of revenues.

We rely on one outside vendor, Bruker Nano GmbH, to manufacture substantial portions of critical hardware that will be used with or included in our XRpro® instruments. We have an agreement with Bruker Nano GmbH for an indefinite period of time to develop a product that incorporates our technology with a product already produced by Bruker. Our agreement with Bruker provides that we will not develop, manufacture, or distribute products that compete directly or indirectly with the product that is supplied by Bruker and incorporated into the XRPro® instruments during the term of the agreement and for a period of three years subsequent to the termination of the agreement if we should terminate the agreement for any reason. Our agreement with Bruker may be terminated by either party without cause upon six (6) months prior written notice.  Bruker is located in Berlin, Germany and its ability to perform the agreement will be affected by the quality controls in Germany, which may be different than those in the Unites States, as well as the regional or worldwide economic, political or governmental conditions.  Disruptions in international trade and finance or in transportation may have a material adverse effect on our business, financial condition and results of operation.  Any significant disruption in those operations for any reason, such as regulatory requirements, scheduling delays, quality control problems, loss of certifications, power interruptions, fires, hurricanes, war or threats of terrorism, labor strikes, contract disputes, could adversely affect our sales and customer relationships. There can be no assurances that a third party contract manufacturer will be able to meet the design specifications of our technology.

Our reliance on one manufacturer is expected to continue and involve several other risks including limited control over the availability of components, delivery schedules, pricing and product quality. We may experience delays, additional expenses and lost sales because of our dependency upon a single manufacturer. If Bruker cannot supply us with adequate equipment in a timely manner, or if we are unable to locate a suitable alternative supplier or at favorable terms, our business could be materially adversely impacted.  While we believe alternative manufacturers exist, we have not specifically identified any alternative manufacturer and may not be able to replace Bruker if we need to in a timely fashion.

Our reliance on a sole supplier involves several risks, including the following:

·  
our supplier of required parts may cease or interrupt production or otherwise fail to supply us with an adequate supply of required parts for a number of reasons, including contractual disputes with our supplier or adverse financial developments at or affecting the supplier;

·  
we have reduced control over the pricing of third party-supplied materials, and our supplier may be unable or unwilling to supply us with required materials on commercially acceptable terms, or at all;

·  
we have reduced control over the timely delivery of third party-supplied materials; and

·  
our supplier may be unable to develop technologically advanced products to support our growth and development of new systems.




In addition, i n the event of a breach of law by us or a breach of a contractual obligation that has an adverse effect upon our operations, we will have little or no recourse because all of our manufacturer’s assets are located in Germany. In addition, it may not be possible to effect service of process in Germany and uncertainty exists as to whether the courts in Germany would recognize or enforce judgments of U.S. courts obtained against a German company.

We must expend a significant amount of time and resources to develop new products, and if these products do not achieve commercial acceptance, our operating results may suffer.

We expect to spend a significant amount of time and resources to develop new products and refine existing products, and have spent significant time and money developing our XRpro® instruments . In light of the long product development cycles inherent in our industry, these expenditures will be made well in advance of the prospect of deriving revenues from the sale of new products. Our ability to commercially introduce and successfully market new products is subject to a wide variety of challenges during this development cycle that could delay introduction of these products. In addition, since our potential customers are not expected to be obligated by long-term contracts to purchase our products, our anticipated product orders may not materialize, or orders that do materialize may be canceled. As a result, if we do not achieve market acceptance of new products, our operating results will suffer. Our products may also be priced higher than competitive products, which may impair commercial acceptance. We cannot predict whether new products that we expect to introduce will achieve commercial acceptance.
 
Our Chief Executive Officer  beneficially owns and  controls a substantial portion of our outstanding common stock, which may limit your ability and the ability of our other stockholders, whether acting alone or together, to propose or direct the management or overall direction of our Company.
 
The concentration of ownership of our stock could discourage or prevent a potential takeover of our Company that might otherwise result in an investor receiving a premium over the market price for his shares. A substantial portion of our outstanding shares of common stock is beneficially owned and controlled by our Chief Executive Officer a. Accordingly, our Chief Executive Officer would have the power to control the election of our directors and the approval of actions for which the approval of our stockholders is required. If you acquire shares of our common stock, you may have no effective voice in the management of our Company. Such concentrated control of our Company may adversely affect the price of our common stock. Our principal stockholders may be able to control matters requiring approval by our stockholders, including the election of directors, mergers or other business combinations. Such concentrated control may also make it difficult for our stockholders to receive a premium for their shares of our common stock in the event we merge with a third party or enter into different transactions which require stockholder approval. These provisions could also limit the price that investors might be willing to pay in the future for shares of our common stock.
 
If we deliver products with defects, our credibility will be harmed and the sales and market acceptance of our products will decrease.

Our products are complex and may at times contain errors, defects and bugs when introduced. If we deliver products with errors, defects or bugs, our credibility and the market acceptance and sales of our products would be harmed. Further, if our products contain errors, defects or bugs, we may be required to expend significant capital and resources to alleviate such problems. Defects could also lead to product liability as a result of product liability lawsuits against us or against our customers. We may agree to indemnify our customers in some circumstances against liability arising from defects in our products. In the event of a successful product liability claim, we could be obligated to pay significant damages.

Most of our potential customers are from the pharmaceutical and biotechnology industries and are subject to risks faced by those industries.

We expect to derive a significant portion of our future revenues from sales to pharmaceutical and biotechnology companies. As a result, we will be subject to risks and uncertainties that affect the pharmaceutical and biotechnology industries, such as availability of capital and reduction and delays in research and development expenditures by companies in these industries, pricing pressures as third-party payers continue challenging the pricing of medical products and services, government regulation, and the uncertainty resulting from technological change.

In addition, our future revenues may be adversely affected by the ongoing consolidation in the pharmaceutical and biotechnology industries, which would reduce the number of our potential customers. Furthermore, we cannot assure you that the pharmaceutical and biotechnology companies that may be our customers will not develop their own competing products or capabilities, or choose our competitors’ technology instead of our technology.
 
 
We will need to depend on credit terms and lines of credit from our contract manufacturers.

In order for us to achieve our business plan, we may require significant lines of credit and credit terms with our third party contract manufacturer of our XRpro® instruments. If we are unable to secure lines of credit and credit terms with our third party contract manufacturers we will have significant difficulties manufacturing and marketing our XRpro® instruments and achieving our business plan.

Many of our current and potential competitors have significantly greater resources than we do, and increased competition could impair sales of our products and services.

We operate in a highly competitive industry and face competition from companies that design, manufacture and market instruments for use in the life sciences research industry, from genomic, pharmaceutical, biotechnology and diagnostic companies and from academic and research institutions and government or other publicly-funded agencies, both in the United States and elsewhere. We may not be able to compete effectively with all of these competitors. Many of these companies and institutions have greater financial, engineering, manufacturing, marketing and customer support resources than we do. As a result, our competitors may be able to respond more quickly to new or emerging technologies or market developments by devoting greater resources to the development, promotion and sale of products, which could impair sales of our products. Moreover, there has been significant merger and acquisition activity among our competitors and potential competitors. These transactions by our competitors and potential competitors may provide them with a competitive advantage over us by enabling them to rapidly expand their product offerings and service capabilities to meet a broader range of customer needs. Many of our potential customers are large companies that require global support and service, which may be easier for our larger competitors to provide.

We believe that competition within the markets we serve is primarily driven by the need for innovative products that address the needs of customers. We attempt to counter competition by seeking to develop new products and provide quality, cost-effective products and services that meet customers’ needs. We cannot assure you, however, that we will be able to successfully develop new products or that our existing or new products and services will adequately meet our potential customers’ needs.

Rapidly changing technology, evolving industry standards, changes in customer needs, emerging competition and frequent new product and service introductions characterize the markets for our products. To remain competitive, we may be required to develop new products and periodically enhance our existing products in a timely manner. We may face increased competition as new companies enter the market with new technologies that compete with our products and future products, and our services and future services. We cannot assure you that one or more of our competitors will not succeed in developing or marketing technologies,  products or services that are more effective or commercially attractive than our products or future products, or our services or future services, or that would render our technologies and products obsolete or uneconomical. Our future success will depend in large part on our ability to maintain a competitive position with respect to our current and future technologies, which we may not be able to do. In addition, delays in the launch of our new products or the provision of our services may result in loss of market share due to our customers’ purchases of competitors’ products or services during any delay.

We depend on our key personnel, the loss of whom would impair our ability to compete.

We are highly dependent on the employment services of Dr. Benjamin Warner, our Chief Executive Officer. The loss of Dr. Warner’s services could adversely affect us. We are also dependent on the other members of our management, engineering and scientific staff. The loss of the service of any of these persons could seriously harm our product development and commercialization efforts. In addition, research, product development and commercialization will require additional skilled personnel in areas such as chemistry and biology, and software and electronic engineering. Our corporate headquarters are located in Los Alamos, New Mexico, where recruitment and retention of skilled personnel are difficult. As a result, recruitment and retention of personnel, particularly for employees with technical expertise, is uncertain. If we are unable to hire, train and retain a sufficient number of qualified employees, our ability to conduct and expand our business could be seriously reduced. The inability to retain and hire qualified personnel could also hinder the planned expansion of our business and may result in us relocating some or all of our operations.

We are dependent on our licensed technology from the Los Alamos National Security.

Our success will depend in part upon the use of patents, pending patents, and technology licensed from the managers of the Los Alamos National Security (“LANS”) pursuant to an exclusive Patent License Agreement. Under this agreement, we have the exclusive rights to a set of issued and pending patents. The agreement imposes royalty payment requirements, reporting requirements, commercialization milestones and other obligations upon us, and there is no assurance that we will be able to operate sufficiently to satisfy these royalty payments, commercialization milestones and other obligations, which could result in loss of license rights to the technology. Our license to the technology is terminable by the managers of LANS upon written notice to us in the event of the failure by us to meet any of our royalty payment or reporting obligations or in the event of any breach by us of any material term of the license agreement.
 
 
We believe the managers of LANS have not fully complied with their responsibilities under the Patent License Agreement (See Business-Legal Proceedings). This has compromised our ability to protect our licensed intellectual property rights and maintain exclusive rights to the licensed technology. Accordingly, our ability to realize the full value of the licensed patents and technology may be compromised, and may dissuade potential customers of our technology and make it easier for competitors to compete with us. We are currently in litigation with the managers of LANS in order to attempt recovery of damages, however there can be no assurance of success in this effort. In addition, there can be no assurance that the managers of LANS will further comply with their responsibilities under the Patent License Agreement.
 
In addition to patents and patent applications that we have licensed from the managers of LANS, we have pending patent applications that have been assigned to us from our current and former employees as inventors. There can be no assurances that the patents will ever be issued for our applications, or that any patents that do get issued will be upheld.

We have initiated and may in the future need to initiate lawsuits to protect or enforce our patents, which would be expensive and, if we lose, may cause us to lose some of our intellectual property rights, which would reduce our ability to compete in the market.

Our success will depend in part upon protecting our technology from infringement, misappropriation, duplication and discovery, and avoiding infringement and misappropriation of third party rights. We intend to rely, in part, on a combination of patent and contract law to protect our technology in the United States and abroad.

The risks and uncertainties that we face with respect to our patents and other proprietary rights include the following:

·  
the pending patent applications we have filed or to which we have exclusive rights may not result in issued patents or may take longer than we expect to result in issued patents;
·  
the claims of any patents which are issued may not provide meaningful protection;
·  
we may not be able to develop additional proprietary technologies that are patentable;
·  
the patents licensed or issued to us or our customers may not provide a competitive advantage;
·  
other companies may challenge patents licensed or issued to us or our customers;
·  
patents issued to other companies may harm our ability to do business;
·  
other companies may independently develop similar or alternative technologies or duplicate our technologies; and
·  
other companies may design around the technologies we have licensed or developed.

There can be no assurance that any of our patent applications or licensed patent applications will issue or that any patents that may issue will be valid and enforceable. We may not be successful in securing or maintaining proprietary patent protection for our products and technologies that we develop or license. In addition, our competitors may develop products similar to ours using methods and technologies that are beyond the scope of our intellectual property protection, which could reduce our anticipated sales. While some of our products have proprietary patent protection, a challenge to these patents can subject us to expensive litigation. Litigation concerning patents, other forms of intellectual property, and proprietary technology is becoming more widespread and can be protracted and expensive and distract management and other personnel from performing their duties.

We also rely upon trade secrets, unpatented proprietary know-how, and continuing technological innovation to develop a competitive position.   If these measures do not protect our rights, third parties could use our technology, and our ability to compete in the market would be reduced. In addition, employees, consultants and others who participate in the development of our products may breach their agreements with us regarding our intellectual property, and we may not have adequate remedies for the breach. We also may not be able to effectively protect our intellectual property rights in some foreign countries and our trade secrets may become known through other means not currently foreseen by us . We cannot assure you that others will not independently develop substantially equivalent proprietary technology and techniques or otherwise gain access to our trade secrets and technology, or that we can adequately protect our trade secrets and technology.

There can be no assurance that third parties will not assert infringement or other claims against us with respect to rights to any of our products. Litigation to protect and defend the rights to our licensed technology or to determine the validity of any third party claims could result in significant expense to us and divert the efforts of our technical and management personnel, whether or not such litigation is determined in our favor. If we determine that additional rights are necessary for the development of our product(s) and further determine that a license to additional third party rights is needed, there can be no assurance that we can obtain a license from the relevant party or parties on commercially reasonable terms, if at all. We could be sued for infringing patents or other intellectual property that purportedly cover products and/or methods of using such products held by persons other than us. Litigation arising from an alleged infringement could result in removal from the market, or a substantial delay in, or prevention of, the introduction of our products, any of which could have a material adverse effect on our business, financial condition, results of operations, and cash flows.

Additionally, in order to protect or enforce our patent rights, we may initiate patent litigation against third parties, such as infringement suits or interference proceedings. Litigation may be necessary to:

 
·  
assert claims of infringement;
·  
enforce our patents;
·  
protect our trade secrets or know-how; or
·  
determine the enforceability, scope and validity of the proprietary rights of others.

Lawsuits could be expensive, take significant time and divert management’s attention from other business concerns. They would put our licensed patents at risk of being invalidated or interpreted narrowly and our patent applications at risk of not issuing. We may also provoke third parties to assert claims against us. Patent law relating to the scope of claims in the technology fields in which we operate is still evolving and, consequently, patent positions in our industry are generally uncertain. If initiated, we cannot assure you that we would prevail in any of these suits or that the damages or other remedies awarded, if any, would be commercially valuable. During the course of these suits, there could be public announcements of the results of hearings, motions and other interim proceedings or developments in the litigation. If securities analysts or investors were to perceive any of these results to be negative, our stock price could decline.

We may incur substantial liabilities and may be required to limit commercialization of our products in response to product liability lawsuits.

We could be the subject of complaints or litigation from customers alleging product quality or operational concerns. Litigation or adverse publicity resulting from these allegations could materially and adversely affect our business, regardless of whether the allegations are valid or whether we are liable. We currently do not have product liability insurance coverage, and even if there was such coverage, there would be no assurance that such coverage would be sufficient to properly protect us. Further, claims of this type, whether substantiated or not, may divert our financial and management resources from revenue generating activities and the business operation.

We may be subject to the risks of doing business internationally.

We plan to offer our products outside of the United States, intend to manufacture products at Bruker’s facility in Germany and may in the future manufacture all or a portion of our products outside of the United States. Because we intend to do so, our business is subject to risks associated with doing business internationally , including:

·  
political, social and economic instability;
·  
trade restrictions and changes in tariffs;
·  
the impact of business cycles and downturns in economies outside of the United States;
·  
unexpected changes in regulatory requirements that may limit our ability to export our products or sell into particular jurisdictions;
·  
import and export license requirements and restrictions;
·  
difficulties and costs of staffing, managing and monitoring geographically disparate operations;
·  
difficulties in maintaining effective communications with employees and customers due to distance, language and cultural barriers;
·  
disruptions in international transport or delivery;
·  
difficulties in protecting our intellectual property rights, particularly in countries where the laws and practices do not protect proprietary rights to as great an extent as do the laws and practices of the United States;
·  
difficulties in enforcing agreements through non-U.S. legal systems;
·  
longer payment cycles and difficulties in collecting receivables; and
·  
potentially adverse tax consequences.

If any of these risks materialize, our international sales could decrease and our foreign operations could suffer.
 
 
If equity research analysts do not publish research or reports about our business or if they issue unfavorable research or downgrade our common stock, the price of our common stock could decline.
 
The trading market for our common stock will rely in part on the research and reports that equity research analysts publish about us and our business. We do not control these analysts. Equity research analysts may elect not to provide research coverage of our common stock, which may adversely affect the market price of our common stock. If equity research analysts do provide research coverage of our common stock, the price of our common stock could decline if one or more of these analysts downgrade our common stock or if they issue other unfavorable commentary about us or our business. If one or more of these analysts ceases coverage of our company, we could lose visibility in the market, which in turn could cause our stock price to decline.

Future sales of our common stock by our existing shareholders could cause our stock price to decline.
 
The Company will have a significant number of restricted shares that will become eligible for sale shortly after this registration statement is declared effective. We currently have 4,291,620 shares of our common stock outstanding, all of which are restricted securities. Of such amount, the shares being registered herein (1,398,264 shares) will be eligible for sale immediately upon the effectiveness of this registration statement. All of the remaining shares will be eligible for resale under Rule 144 within ninety days of us being a reporting company under Section 13 or 15 of the Securities Exchange Act of 1934 (the “Exchange Act”); however  3,340,700 will be held by affiliates and will be subject to the limitations described under “Shares Eligible For Future Sale.” It is conceivable that following the holding period, many shareholders may wish to sell some or all of their shares. If our shareholders sell substantial amounts of our common stock in the public market at the same time, the market price of our common stock could decrease significantly due to an imbalance in the supply and demand of our common stock. Even if they do not actually sell the stock, the perception in the public market that our shareholders might sell significant shares of our common stock could also depress the market price of our common stock.
 
A decline in the price of shares of our common stock might impede our ability to raise capital through the issuance of additional shares of our common stock or other equity securities, and may cause you to lose part or all of your investment in our shares of common stock.

Shareholders purchasing shares in this offering do not have pre-emptive rights, which will cause them to experience dilution if we issue additional securities.

At any time or times after this offering, we may issue and sell additional shares of our authorized but previously unissued shares of common stock, preferred stock, or common stock warrants on such terms and conditions as our Board of Directors, in its sole discretion, may determine without consent of our shareholders. Our shareholders do not have pre-emptive rights to acquire additional shares should we in the future issue or sell additional securities. Thus, we are not required to offer any existing shareholder the right to purchase his or her pro rata portion of any future issuance of securities and, therefore, upon the issuance of any additional securities by us hereafter, our shareholders will not be able to maintain their then existing pro rata ownership in our outstanding shares of common stock, preferred stock, or common stock warrants without additional purchases of securities at the price then set internally by us.

We do not expect to pay dividends on our common stock in the foreseeable future.

We do not expect to pay dividends on common stock for the foreseeable future, and we may never pay dividends.  Consequently, the only opportunity for investors to achieve a return on their investment may be if a trading market develops and investors are able to sell their shares for a profit or if our business is sold at a price that enables investors to recognize a profit. However, our Series A preferred stockholders are entitled to an annual dividend of $.46 per share of preferred stock payable in cash or stock at the option of the holder We currently intend to retain any future earnings other than those paid as dividends to Series A preferred holders to support the development and expansion of our business and do not anticipate paying cash dividends for the foreseeable future. Our payment of any future dividends will be at the discretion of our Board of Directors after taking into account various factors, including but not limited to our financial condition, operating results, cash needs, growth plans and the terms of any credit agreements that we may be a party to at the time. In addition, our ability to pay dividends on our common stock may be limited by state law. Accordingly, we cannot assure investors any return on their investment, other than in connection with a sale of their shares or a sale of our business. At the present time there is a limited trading market for our shares. Therefore, holders of our securities may be unable to sell them. We cannot assure investors that an active trading market will develop or that any third party will offer to purchase our business on acceptable terms and at a price that would enable our investors to recognize a profit.

We have no independent audit committee nor do we have an audit committee financial expert at this time. Our full board of directors functions as our audit committee. This may hinder our board of directors’ effectiveness in fulfilling the functions of the audit committee.

Currently, we have no independent audit committee nor do we have an audit committee financial expert at this time. Our full board of directors functions as our audit committee and is comprised of three directors, two of whom are not considered to be "independent" in accordance with the requirements of Rule 10A-3 under the Exchange Act. An independent audit committee plays a crucial role in the corporate governance process, assessing our Company's processes relating to our risks and control environment, overseeing financial reporting, and evaluating internal and independent audit processes. The lack of an independent audit committee may prevent the board of directors from being independent from management in its judgments and decisions and its ability to pursue the committee's responsibilities without undue influence. We may have difficulty attracting and retaining directors with the requisite qualifications. If we are unable to attract and retain qualified, independent directors, the management of our business could be compromised. In addition, no director on our board of directors is considered to be a “financial expert”.

Our board of directors acts as our compensation committee, which presents the risk that compensation and benefits paid to those executive officers who are board members and other officers may not be commensurate with our financial performance.

A compensation committee consisting of independent directors is a safeguard against self-dealing by company executives. Our board of directors acts as the compensation committee and determines the compensation and benefits of our executive officers, administers our employee stock and benefit plans, and reviews policies relating to the compensation and benefits of our employees. Although all board members have fiduciary obligations in connection with compensation matters, our lack of an independent compensation committee presents the risk that our executive officer on the board may have influence over his personal compensation and benefits levels that may not be commensurate with our financial performance.


Limitations on director and officer liability and indemnification of our Company’s officers and directors by us may discourage stockholders from bringing suit against an officer or director.

Our Company’s certificate of incorporation and bylaws provide, with certain exceptions as permitted by governing state law, that a director or officer shall not be personally liable to us or our stockholders for breach of fiduciary duty as a director or officer, except for acts or omissions which involve intentional misconduct, fraud or knowing violation of law, or unlawful payments of dividends. These provisions may discourage stockholders from bringing suit against a director or officer for breach of fiduciary duty and may reduce the likelihood of derivative litigation brought by stockholders on our behalf against a director or officer.

We are responsible for the indemnification of our officers and directors.

Should our officers and/or directors require us to contribute to their defense, we may be required to spend significant amounts of our capital. Our certificate of incorporation and bylaws also provide for the indemnification of our directors, officers, employees, and agents, under certain circumstances, against attorney's fees and other expenses incurred by them in any litigation to which they become a party arising from their association with or activities on behalf of our Company. This indemnification policy could result in substantial expenditures, which we may be unable to recoup. If these expenditures are significant, or involve issues which result in significant liability for our key personnel, we may be unable to continue operating as a going concern.
 
The rights of our preferred stock could negatively affect holders of common stock and make it more difficult to effect a change of control.
 
Our board of directors is authorized by our charter to create and issue preferred stock. Certain of the rights of holders of preferred stock take precedence over the rights of holders of common stock.  We have issued 341,607 shares of  Series A preferred stock   The holders of  the Series A preferred stock are entitled to a dividend of $.46 per share each year payable in cash or stock at the option of the holder and is entitled to a preference upon our liquidation, dissolution or winding up. The shares are convertible voluntarily at the election of the holder and automatically ten trading days after delivery to the holder by us of a notice that the volume-weighted average closing price of our common stock over the ten trading days immediately preceding the date of notice is at least $10.00 per share. The holders are also entitled to registration rights with respect to such shares.   We may issue additional shares of Series A preferred stock in addition to other preferred stock. As future tranches of capital are received by the Company, additional preferred stock may be issued which such terms and preferences as are determined in the sole discretion of our board of directors. The rights of future preferred stockholders could delay, defer or prevent a change of control, even if the holders of common stock are in favor of that change of control, as well as enjoy preferential treatment on matters like distributions, liquidation preferences and voting.

Our common stock may be thinly traded, so you may be unable to sell at or near ask prices or at all if you need to sell your shares to raise money or otherwise desire to liquidate your shares.

Prior to this offering, you could not buy or sell our common stock publicly. We cannot predict the extent to which investors’ interests will lead to an active trading market for our common stock or whether the market price of our common stock will be volatile following this offering. If an active trading market does not develop, investors may have difficulty selling any of our common stock that they buy. There may be limited market activity in our stock and we are likely to be too small to attract the interest of many brokerage firms and analysts. We cannot give you any assurance that a public trading market for our common stock will develop or be sustained. If we trade on OTC markets, the trading volume we will develop may be limited by the fact that many major institutional investment funds, including mutual funds as well as individual investors, follow a policy of not investing in OTC stocks and certain major brokerage firms restrict their brokers from recommending OTC stocks because they are considered speculative, volatile, thinly traded and the market price of the common stock may not accurately reflect the underlying value of our Company. The market price of our common stock could be subject to wide fluctuations in response to quarterly variations in our revenues and operating expenses, announcements of new products or services by us, significant sales of our common stock, including “short” sales, the operating and stock price performance of other companies that investors may deem comparable to us, and news reports relating to trends in our markets or general economic conditions.


The application of the “penny stock” rules to our common stock could limit the trading and liquidity of the common stock, adversely affect the market price of our common stock and increase your transaction costs to sell those shares.

As long as the trading price of our common stock is below $5 per share, the open-market trading of our common stock will be subject to the “penny stock” rules, unless we otherwise qualify for an exemption from the “penny stock” definition. The “penny stock” rules impose additional sales practice requirements on certain broker-dealers who sell securities to persons other than established customers and accredited investors (generally those with assets in excess of $1,000,000 or annual income exceeding $200,000 or $300,000 together with their spouse). These regulations, if they apply, require the delivery, prior to any transaction involving a penny stock, of a disclosure schedule explaining the penny stock market and the associated risks. Under these regulations, certain brokers who recommend such securities to persons other than established customers or certain accredited investors must make a special written suitability determination regarding such a purchaser and receive such purchaser’s written agreement to a transaction prior to sale. These regulations may have the effect of limiting the trading activity of our common stock, reducing the liquidity of an investment in our common stock and increasing the transaction costs for sales and purchases of our common stock as compared to other securities. The stock market in general and the market prices for penny stock companies in particular, have experienced volatility that often has been unrelated to the operating performance of such companies. These broad market and industry fluctuations may adversely affect the price of our stock, regardless of our operating performance. Stockholders should be aware that, according to Securities and Exchange Commission (“SEC”) Release No. 34-29093, the market for penny stocks has suffered in recent years from patterns of fraud and abuse. Such patterns include: (i) control of the market for the security by one or a few broker-dealers that are often related to the promoter or issuer; (ii) manipulation of prices through prearranged matching of purchases and sales and false and misleading press releases; (iii) boiler room practices involving high-pressure sales tactics and unrealistic price projections by inexperienced sales persons; (iv) excessive and undisclosed bid-ask differential and markups by selling broker-dealers; and (v) the wholesale dumping of the same securities by promoters and broker-dealers after prices have been manipulated to a desired level, along with the resulting inevitable collapse of those prices and with consequent investor losses. The occurrence of these patterns or practices could increase the volatility of our share price.

We may not be able to attract the attention of major brokerage firms, which could have a material adverse impact on the market value of our common stock. 

Security analysts of major brokerage firms may not provide coverage of our common stock since there is no incentive to brokerage firms to recommend the purchase of our common stock. The absence of such coverage limits the likelihood that an active market will develop for our common stock. It will also likely make it more difficult to attract new investors at times when we require additional capital.

Future sales of our equity securities could put downward selling pressure on our securities, and adversely affect the stock price.

There is a risk that this downward pressure may make it impossible for an investor to sell his securities at any reasonable price, if at all. Future sales of substantial amounts of our equity securities in the public market, or the perception that such sales could occur, could put downward selling pressure on our securities, and adversely affect the market price of our common stock.

USE OF PR O CEEDS

We will not receive any proceeds from the sale of the common stock by the selling security holders pursuant to this prospectus. All proceeds from the sale of the shares will be for the account of the selling security holders.
 
BUSIN ES S
 
We were incorporated in the State of Delaware on November 12, 2003.  On March 14, 2011, the Company filed a First Amended and Restated Certificate of Incorporation with the Secretary of State of Delaware increasing the authorized common shares from 10,000,000 to 50,000,000 and the issuance of up to 10,000,000 preferred shares. Subsequently, we filed a Certificate of Designations on March 14, 2011, which designated all of our 10,000,000 shares of preferred stock as Series A preferred stock.   See “Risk Factors – Issuance of preferred stock could hurt holders of common stock on page 15.   The Company has reserved up to 3,000,000 shares for issuance to employees, directors and others in accordance with the terms of our 2005 Stock Option Plan.
 
History

Caldera was founded by Dr. Benjamin Warner in 2003 at the request of the then director of Los Alamos National Laboratory (“LANL”) for the purpose of commercializing previous work done by Dr. Warner at LANL regarding the use of x-ray fluorescence to measure the chemical composition of pharmaceuticals. Dr. Warner earned his PhD in Chemistry from the Massachusetts Institute of Technology (“MIT”) in 1995. After MIT, Dr. Warner joined LANL where he held various positions including the position of Project Leader for National Security Programs from 2000 until 2004.


While at LANL, Dr. Warner patented through the auspices of the University of California (then the manager of LANL) his improvement to x-ray fluorescence technology that allowed it to be used to measure nanograms of material. This improvement made x-ray fluorescence economically feasible to measure the chemical composition of pharmaceuticals.

Dr. Warner has won numerous awards from Los Alamos National Laboratory for his commercialization and patenting work, including the Distinguished Licensing Award, the Distinguished Entrepreneurial Award, the Distinguished Patent Award, and the Federal Laboratory Consortium Distinguished Service Award. Jointly with LANL, Caldera Pharmaceuticals won the 2007 Federal Laboratory Consortium Award for Excellence in Technology Transfer and an R&D100 Award. Caldera has won multiple Technology Ventures Corporation awards for top technology companies in New Mexico.

Our Current and Future Business

We are a research and development firm engaged in various aspects of drug discovery. The cornerstone of our business is our unique technology that is based on direct chemical analysis of protein-drug combinations by means of micro X-ray fluorescence spectroscopy. We currently offer our customers analytical services using our technology to evaluate drug candidates for safety and efficacy. We believe that our technology can reduce the cost of drug discovery by detecting safety and efficacy issues at an early stage of development.  To date, substantially all of our revenue has been derived from our analytical services that we have performed for United States governmental agencies.  However, we expect that our future revenue will be derived from three lines of business: (i) provision of our analytical drug discovery services; (ii) sale of our drug discovery instruments; and (iii) sale of new drug candidates that we identify using the XRpro® drug discovery instruments that we are currently developing and commercialization. We intend to expand our customer base to begin providing our analytical services to biotechnical and pharmaceutical customers in addition to the government sector.   We have developed a stand-alone unit, of our XRpro® drug discovery instrument that can be sold to customers, such as pharmaceutical and biotech companies that would allow them to use our technology to conduct the same analytical services that we provide for the United States government.  We also anticipate deriving revenue from the development of drugs that are presented to us when conducting our chemical analysis.

XRpro® Drug Discovery Services

We currently derive substantially all of our revenue from the provision of our analytical drug discovery services to the federal government. The Company believes that due to the unique properties of its technology there is the potential to expand its customer base to include private enterprises, such as pharmaceutical companies which conduct large-scale research and development of new drug candidates.  As a result, the Company plans to expand its outsourced drug discovery and screening services to include a larger customer base, primarily targeting pharmaceutical companies.

XRpro® Drug Discovery Instruments

The   XRpro® instrument is a high-throughput x-ray fluorescence microscope. In July 2011, we entered into an exclusive contract with Bruker Nano GmbH, a German company engaged in the manufacture and sale of components and systems for micro and nanoanalysis of electron microscopes, to customize its desk top analyzer by incorporating our improvements and intellectual property into its already existing product. The agreement is for an indefinite term but may be terminated by either party without cause upon six months notice or immediately upon the happening of certain events, including bankruptcy, violation of export laws and nonpayment of commitments of $100,000 or more.  The agreement includes a non-competition provision specifying that we cannot copy the product manufactured by Bruker and that Bruker will not sell such product to any third party or end user that competes with us.

We have not sold any XRpro® instruments; however, we have begun initial marketing of the XRpro® instrument. Although the Company has not shipped XRpro® instruments to the private sector, we believe that use of the XRopro instrument can demonstrate significant cost savings by allowing pharmaceutical companies to combine multiple safety and efficacy tests in the drug discovery process at a price substantially lower than current industry standards without the need to modify the drug, protein, or cell, or use expensive reagents.

New Drug Candidates

We are developing new drug candidates, primarily paid for by Federal contracts. We have developed new molecules including new MRI contrast agents, radiopharmaceuticals, anti-infectives, and therapies for heavy metal toxicity. These chemicals have been developed using our XRpro® technology and have been tested using in vitro safety and efficacy models. We plan to further develop these molecules as far as possible using Federal contracts and grants that pay for substantially all the research and development costs. We obtained a $3,000,000 grant in August 2011 to conduct animal trials for one of our drug candidates.

 
Our Analysis Technology

Our XRpro® technology quantifies drug/protein interactions without the need to modify the drug, protein, or cell, or use expensive reagents.  Many technologies require that expensive reagents (substances that are added to a system in order to bring about a  chemical reaction  or is added to see if a reaction occurs) or “labels” be used to measure the properties of drug candidates during the drug discovery process. These reagents are expensive, and can introduce experimental errors, wasting billions of dollars each year. Label-free technologies are particularly sought by the pharmaceutical industry because it is believed that they provide superior data at lower cost. Our high-throughput XRpro® technology measures approximately 2,000,000 compounds per month. Our technology measures multiple parameters for both drugs and proteins. This allows, for example, the ability to measure multiple interactions between a single drug and multiple proteins in a single measurement.  We therefore measure on-target (i.e., efficacy) and off-target ( i.e. side effects/toxicity) properties simultaneously.

Our high-throughput XRpro® technology does not require the use of expensive reagents, chemical dyes or radiological labels, which are commonly required for competing techniques. The use of a reagent in the analysis process, for a typical high-throughput campaign, can typically cost up to $0.50 per compound. Based on such costs, we believe that our XRpro® technology saves the customer approximately $500,000 per month for a typical high-throughput screening rate of 1,000,000 compounds per month.

We believe that our ability to provide our services in a cost and time efficient manner will allow us to profitably offer and expand our XRpro® drug discovery services to biotech and pharmaceutical companies as well as to cost-effectively continue our development of new drug candidates.

Scientific Advantages of XRpro ®

The pharmaceutical industry uses assays to measure the properties of experimental medicines. XRpro® allows multiple assays to be conducted at significantly lower costs than existing techniques.  XRpro® assays include:

•  
Functional Assays, or to what extent a drug inhibits a protein target;
•  
Binding Assays, or whether a drug binds to a protein;
•  
Cell Assays, such as whether a drug acts upon a cell model for a disease;
•  
Ion Channel Assays, or whether a drug inhibits hERG protein, which is associated with cardiotoxicity;

Some of the key features of XRpro® are the following:

•  
Price of the instrument - XRpro® is priced similar to other instruments that have large monthly reagent or label costs;
•  
Monthly costs - XRpro® dramatically reduces costs by eliminating the need for reagents, antibodies and labels, allowing savings of approximately $500K per month;
•  
Fast -. XRpro® currently runs at a rate of 2,000,000 measurements per month;
•  
Sensitive - XRpro® measures nanograms of material, which has allowed us to reduce protein consumption tenfold in some cases;
•  
Precise - XRpro® has demonstrated Z-Factors, which are a common measurement of assay precision, above 0.8. This is roughly equivalent to 12 standard deviations between an assay and a blank;
•  
Durable - XRpro® allows samples to be read dry, months after assay, in contrast to most competing assays which must be read wet, and shortly after the assay was run; and
•  
Data Rich - XRpro® allows simultaneous on-target and cross-target functional assays, which gives an estimate of both safety and toxicity.

The underlying science of XRpro® is similar to the more commonly used optical fluorescence. In optical fluorescence, light having energy of 2-3 electron volts (eV) is shone on a sample, which then emits another wavelength of light. The amount of light that is emitted and its wavelength provide information about what chemicals are present, and in what quantities.  In optical fluorescence, the fluorophore, or potion of the molecule that emits light, is large and often expensive.

XRpro®, on the other hand, uses x-rays, which have different properties than the light used in optical fluorescence. The most important of these properties is that the portion of the molecule that emits photons is an atom. XRpro® directly quantifies atoms that are present in many drugs, proteins, and functional assays. This feature is what produces the huge cost savings of XRpro®.

Market

According to a March 16, 2010 article published by www.phrma.org , analyses performed by the Pharmaceutical Research and Manufacturers of America (PhRMA), which represents many pharmaceutical research and biotechnology companies, and Burrill & Company, a global financial services firm focused on the life sciences industry, US pharmaceutical companies invested $67.4 billion in 2010 in the research and development of medicines and vaccines.  Further, global R&D spending is expected to grow by about 5.2% to more than $1.4 trillion in 2012, according to the 2012 Global R&D Funding Forecast published by Battelle, an independent research and development organization.  According to Battelle, most of the global funding growth is being driven by Asian economies, which are expected to increase nearly 9% in 2012, while European R&D will grow by about 3.5% and North American R&D by 2.8%. U.S. R&D is forecast to grow 2.1% in 2012 to $436 billion.

According to PhRMA, only one of every 10,000 potential medicines investigated by America's research-based pharmaceutical companies makes it through the research and development pipeline and is approved for patient use by the Food and Drug Administration (FDA). On average, according to PhRMA, approval requires 15 years of R&D and costs more than $1 billion. Potential new medicines pass through several crucial stages on their way from research laboratories to the pharmacy shelf. These stages begin with discovery , which includes determining the biological mechanism to treat an illness, and creating and testing chemicals to counteract that mechanism of the illness. The next stage is preclinical development , which includes creating and testing hundreds of chemical analogs of the chemicals identified in discovery to identify those chemicals that are both safe and effective enough to test in human volunteers. The final stage before approval is clinical trials , which includes testing the medicine on volunteers for safety and then efficacy.  Our proprietary XRpro® technology focuses on the preclinical stage. We believe that the XRpro® will significantly reduce the costs of preclinical tests, and allow multiple tests to be performed simultaneously, reducing the time and costs required to evaluate drug candidates for safety and efficacy.
 
 
According to research data collected by Frost & Sullivan, an international marketing and growth consulting firm, worldwide revenue for all laboratory products reached $36.2 billion in 2010, and the US laboratory products market was approximately $13.7 billion in 2010. Instruments and equipment comprise about one-third of this market, and chemicals and reagents comprise about one quarter of this market. The overall marketplace in which the Company’s XRPro® drug discovery instruments and XRpro® drug discovery services competes is therefore approximately $8 billion per year in the US alone.

Competition

The life sciences research market is very competitive and includes a number of companies, such as Affymetrix ,Agilent Technologies Inc., Bio-Tek Instruments, Inc., Danaher, ForteBio (acquired by Pall), GE Healthcare, Illumina, PerkinElmer, Spectris, Tecan Group Ltd. and Thermo Fisher Scientific, that offer, or may in the future offer, products with performance capabilities generally similar to those offered by our products. We expect that competition is likely to increase in the future, as several current and potential competitors who have the technological and financial ability to enter the markets that we serve enter the markets. Many of our life sciences research products are priced at a premium; in these markets, we compete primarily on the basis of performance and productivity. Many companies, research institutions and government organizations that might otherwise be customers for our products employ methods for analysis that are internally developed.

Many of our competitors have significantly greater financial, technical, marketing, sales and other resources than we do. In addition to competing with us with respect to product sales, these companies and institutions compete with us in recruiting and retaining highly qualified scientific and management personnel.

We offer what we believe to be a superior technology to measure the properties of drug candidates. Our major competing technology is drug labeling which is currently the most used technique for measuring the binding of drugs to proteins. While commonly used, it produces results of inconsistent reliability because of the added reagents that can bias the test results, thereby diminishing the value of test. Companies providing these technologies include DiscoveRx, PerkinElmer and Promega.

Another competing technology is surface plasmon resonance. This technology moves the label from the drug to the protein, which partially – but not completely – mitigates the reliability problems. The label on the protein often interferes with protein function. It is also expensive and currently not very high-throughput. Companies providing SPR include GE Healthcare, SRU, Graffinity and Corning.

A final group of potential competitors may be companies that manufacture X-Ray fluorescence equipment based upon similar technology to ours that also does not require the use of any reagents. These include EDAX, Horiba and PANalytical. We believe that our intellectual property portfolio and our partnership with Bruker place us in a favorable position in relation to these potential competitors.

Intellectual Property Rights
 
In September 2005, we entered into an agreement with The Regents of the University of California which was subsequently assigned to the Los Alamos National Security, LLC. The license grants to us the exclusive right to hold, use and sell inventions under a portfolio of issued patents and pending patents for our current technology, a method for detecting binding constants using micro x-ray fluorescence. The University retained the right to use the technology for noncommercial purposes and the United States government has a nonexclusive license to have practiced the technology.  We also agreed to allow the University to use all improvements on the technology developed by us. The agreement was effective upon execution and terminates after the expiration of the last patent unless terminated earlier.  The agreement provides that the University can terminate the agreement if, after a 60 day cure period, we fail to deliver any required reports, make any required payments or if we breach any material terms of the agreement.  It also provides for immediate termination upon receipt of a notice of our filing of a bankruptcy petition. We have the right to terminate the agreement upon 90 days notice; however a termination does not relieve us of any payment or other obligations that were already due.  Upon execution of the agreement we paid a $40,000 upfront nonrefundable fee, in addition to our issuance of shares of our common stock representing three percent (3%) of our outstanding equity, which was later assigned by the University to Los Alamos National Security LLC.  Such stock is nondilutable and the holder has the right to publicly sell shares if we complete an initial public offering.  We are also obligated to make annual payments to the University of $25,000 each year until 2011 and then $50,000 until 2020, and  royalty payments of 2% of Net Sales (as defined in the agreement), additional fees on sublicensed revenue and $20,000 per each United States patent that is issued. Under the license, Caldera has the exclusive commercial rights to the following patents, patent applications, and any divisional and continuation patents:
 
 
·  
Patent Application 09/859,701, Method for Detecting Binding Events Using Micro X-Ray Fluorescence Spectrometry;
·  
Patent Application 10/206,524, Flow Method and Apparatus for Screening Chemicals Using Micro X-Ray Fluorescence;
·  
Patent Application 10/621,825, Method and Apparatus for Detecting Chemical Binding; and
·  
Patent Application 10/880,388, Drug Development and Manufacturing..

 We have filed the following published patent applications to further buttress our intellectual property position:

·  
Patent application 20100003697, Method and Apparatus for Measuring Analyte Transport Across Barriers;
·  
Patent application 20090087919, Method and Apparatus for Measuring Protein Post- Translational Modification;
·  
Patent application 20090046832, Well Plate; and
·  
Patent application 20080220441, Advanced drug development and manufacturing (held jointly with the manager of Los Alamos National Laboratory)

We continue to file additional patent applications periodically.

Employees  

As of February 1, 2012, the Company employs seven full-time employees and two part-time employees. None of our employees are subject to collective bargaining agreements.

Backlog

We do not have any material order backlog as of the date of this registration statement.   

Seasonality

We do not expect that our business will experience significant seasonality.  

Property

We lease approximately 5,100 square feet at 278 DP Road, Suite D, Los Alamos, New Mexico 87544, where our corporate offices and laboratory are located. This lease is for a term of 36 months with a six month termination clause, which commenced in November 2010. The current monthly rental payment including utilities and operating expenses for the facility is approximately $6,000 per month. The Company also has an office at 175 West Jackson Blvd. Suite 2230, Chicago, Illinois 60604.We believe these facilities are in good condition and adequate to meet our current and anticipated requirements.

Legal Proceedings

Los Alamos National Security Suit

In October 2010, the Company filed suit against Los Alamos National Security LLC (“LANS”) and seven other co-defendants in the United States District Court For the Northern District of Illinois Eastern Division alleging the following: (i) Breach of Contract; (ii) Fraud; (iii) Intentional Interference with Contractual Relations; (iii) Legal Malpractice; and other related claims in connection with an exclusive Patent Licensing Agreement (the “Agreement”) originally entered into between the Company and the Regents of the University of California (the “Regents”) in September 2005. In April 2006, the Regents assigned the Agreement to LANS. The Company believes the defendants made false representations that were critical to its decision to enter into the Agreement including: (i) the Regents was the lawful owner of the patent rights covered by the Agreement; and (ii) the Regents would prosecute and maintain these patent rights and notify the Company if it decided to abandon them. The Company also believes that LANS and other co-defendants improperly competed with the Company. In addition, the Company believes that two of the co-defendants, both in-house patent attorneys for LANS, breached their professional duties. The Company believes it has suffered substantial damages from the defendants’ actions. The Company also filed suit against the Regents and LANS in California Superior Court in San Francisco in December 2007. This suit was dismissed for reason of lack of subject matter jurisdiction by the Court. We believe that this dismissal was made incorrectly, and are appealing this ruling. The defendants filed countersuits, which were also dismissed. Should LANS or other defendants file or re-file countersuits, the Company intends to vigorously defend itself. In January 2012, this case was ordered to be transferred to Federal Court in New Mexico.


In September 2011, the Company filed suit against the Regents of the University of California and LANS in the Circuit Court of Cook County. LANS removed the case to federal court, Case # ll-CV-07259. The Company's complaint alleges the following: (i) Breach of Contract; (ii) Breach of the Implied Covenant of Good Faith; (iii) Fraud; and (iv) Fraudulent Inducement, in connection with an exclusive Patent Licensing Agreement (the "Agreement") originally entered into between the Company and the Regents of the University of California (the "Regents") in September 2005 and assigned to LANS in April 2006. The Company believes the defendants breached a License Agreement, and made false representations that were critical to the Company's decision to enter into the Agreement. The Company believes it has suffered substantial damages from the Defendants' actions.

Seddie Bastanipour and Joel Bellows Suit

In October 2008, Seddie Bastanipour and Joel Bellows filed suit against the Company, our Chief Executive Officer, Dr. Benjamin Warner, and a former consultant to the Company, Sigmund Eisenchenk. Joel Bellows provided legal services to the Company through his legal firm, Bellows and Bellows P.C. The suit was filed in the Circuit Court of Cook County, Illinois and alleged the following: (i) Violation of Illinois Securities Act of 1953; (ii) Violation of Illinois Consumer Fraud Act; and (iii) Common Law Fraud, in connection with aggregate investments of $218,000 in the Company’s common stock claimed by Bastanipour and Bellows. They are seeking compensatory damages, costs and expenses. The Company does not believe Bellows will prevail on any of the alleged complaints. In December 2011, the Company completed an amicable settlement with Bastanipour.

In March, 2010, the Company filed suit against Joel Bellows and Bellows and Bellows P.C. in the United States District Court for the District of New Mexico alleging the following: (i) Breach of Contract; (ii) Negligence; (iii) Breach of Fiduciary Duty; (iv) Fraud; and (v) Tortious Interference with Contract. The aforementioned complaints relate to legal services provided by Bellows and Bellows P.C. for the Company. The Company is seeking compensatory damages, punitive damages, interest, costs and fees.

In December 2010, the Company filed suit against Seddie Bastanipour and Peter Baltrus for breach of contract and negligence when they were performing accounting services on behalf of the Company which resulted in an IRS penalty. In December, 2011, the Company completed an amicable settlement with Bastanipour and she is no longer party to either suit. Baltrus claims to have been working for Bellows (see above) at all relevant times; the case against Peter Baltrus continues. The Company has entered into further settlement discussions with Peter Baltrus.

Holders

As of February 1, 2012, there were approximately 63 stockholders of record of our common stock.

Dividends
 
We have never declared or paid a cash dividend for common stock. Any future decisions regarding dividends will be made by our board of directors. However, our Series A preferred stockholders are entitled to an annual dividend of $.46 per share of preferred stock payable in cash or stock at the option of the holder. We currently intend to retain and use any future earnings other than those paid to Series A preferred holders as dividends for the development and expansion of our business and do not anticipate paying any cash dividends in the foreseeable future. Our board of directors has complete discretion on whether to pay dividends on our common stock.  Even if our board of directors decides to pay dividends on our common stock , the form, frequency and amount will depend upon our future operations and earnings, capital requirements and surplus, general financial condition, contractual restrictions and other factors that the board of directors may deem relevant.  

Equity Compensation Plans

In 2005 our board of directors adopted the 2005 Stock Option/Stock Issuance Plan (the “Plan”) that was approved by a vote of the majority of our shareholders. The Plan is intended to promote the interests of our Company by providing eligible person with the opportunity to acquire a proprietary interest, or otherwise increase their proprietary interest, in the Company as an incentive for them to be employed by or remain in the service of the Company.  The Plan provides for issuance of incentive stock options or nonqualified stock options.  The maximum number of shares available to be issued under the Plan is currently 3,000,000 shares, subject to adjustments for any stock splits, stock dividends or other specified adjustments which may take place in the future and there are currently 518,445 options issued and outstanding.  The Plan continues until the earlier of termination by the board of directors or when all shares of common stock available for issuance has been issued and all restrictions on such shares under the terms of the Plan have lapsed.
 
 
The Plan is administered by our Company’s board of directors.  Persons eligible to participate in the Plan are: employees; officers, directors, consultants, investors, and service providers to our Company.  All grants under the Plan are intended to comply with the requirements under Internal Revenue Code and activities under the Plan will be administered accordingly.  Options granted under the Plan are evidenced by agreement between the recipient and our Company, subject to the following general provisions: (i) the exercise price shall not be less than 100% of the fair market value per share of our Company’s common stock on the date of grant (110% in the case of 10% or greater shareholders); and (ii) the term of stock options shall be limited to a maximum of ten years.  A complete description of the Plan is included as an exhibit to this registration statement.  
 
SECURITIES AUTHORIZED FOR ISSUANCE UNDER EQUITY COMPENSATION PLANS

The following table provides information regarding the status of our existing equity compensation plans at February 1, 2012.

  
 
Number of securities to be issued upon exercise of outstanding options, warrants and rights
   
Weighted-average exercise price of outstanding options, warrants and rights
   
Number of securities remaining available for future issuance under equity compensation plans
 
                   
Equity compensation plans approved by security holders
   
518,445
     
3.54
     
2,481,555
 
                         
Equity compensation plans not approved by security holders
   
0
     
0
     
0
 
                         
Total
   
518,445
     
3.54
     
2,481,555
 

The number of securities remaining available for future issuance under equity compensation plans approved by security holders totaled 2,481,555 shares at February 8, 2012.
 
MANAGEMENT'S DISCUSSION AND AN ALYS IS OF FINANCIAL CONDITION AND RESULTS OF OPERATIONS
 
The following discussion and analysis is intended as a review of significant factors affecting our financial condition and results of operations for the periods indicated.  The discussion should be read in conjunction with our consolidated financial statements and the notes presented herein. In addition to historical information, the following Management's Discussion and Analysis of Financial Condition and Results of Operations contains forward-looking statements that involve risks and uncertainties. Our actual results could differ significantly from those anticipated in these forward-looking statements as a result of certain factors discussed herein and any other periodic reports filed and to be filed with the Securities and Exchange Commission.

Overview and Financial Condition
 
Discussions with respect to our Company’s operations included herein include the operations of  our operating subsidiary, XRPRO Corp. Our Company formed XRPRO Corp. on July 9, 2010. We have no other operations than those of Caldera Pharmaceuticals, Inc. and XRPRO Corp.
 
Results of Operations for the year ended December 31, 2010 and the year ended December 31, 2009.

Revenues

Our Company had revenues totaling $1,641,582 and $1,600,906 for the years ended December 31, 2010 and 2009, respectively, an increase of approximately 2.5%. Substantially all of our revenues to date have been from Federal government contracts.  Going forward, we plan to heavily market our XRPRO® equipment and services and educate potential customers concerning the advantages and value propositions of the XRPRO® technology.  While we are optimistic about the prospects for our Company, since this is a relatively new product offering with significantly different characteristics compared with existing equipment on the market (and we have not recognized significant revenues to date), there can be no assurance about whether or when our products will generate sufficient revenues with adequate margins in order for our Company to be profitable.
 
 
Cost of goods sold

Cost of goods sold were relatively stable and totaled $760,728 and $755,992 for the years ended December 31, 2010 and 2009, respectively. Cost of goods sold is comprised primarily of direct expenses related to providing our services under government contracts.  These expenses include salary expenses directly related to research contracts, outside consultants and direct materials used on Government contracts.

Gross Profit

Gross margin was $880,854 and $844,914 for the years ended December 31, 2010 and 2009, respectively.   The gross margin percentages of 53.6% and 52.8% for the years ended December 31, 2010 and 2009, respectively, relate to our Federal government contracts and may not be indicative of anticipated future results due to the Company’s plan to diversify its source of revenues into equipment sales and services.  

General and administrative expenses
 
General and administrative expenses totaled $1,609,846 and $858,477 for the years ended December 31, 2010 and 2009, respectively, an increase of 87.5%.  Payroll expenses totaled $337,579 and $348,743 in 2010 and 2009, respectively, Stock based compensation costs, primarily related to stock options amounted to $500,503 and $199,662 in 2010 and 2009, respectively. The increase in our stock based compensation charge was primarily due to stock issued to consultants for services performed to raise equity funding and an increase in the number of options outstanding to employees. Legal expenses totaled $539,786 and $156,512 in 2010 and 2009, respectively. The increase in our legal expenses was primarily due to our funding of expenses related to our suits against Los Alamos National Security LLC. (LANS) and the Regents of the University of California as well as the Bellows litigation (see Business- Legal Proceedings).  While the Company has negotiated a partial contingency fee agreement in the LANS case, the Company will still face significant continuing legal expenses should it continue to pursue its actions. Our legal expenses are not connected with our regular business activities and while still ongoing should be viewed as non operating expenses.  We are plaintiffs in two lawsuits and therefore to some extent we have some degree of control as to whether we will continue to fund this litigation.  At present it is our judgment that the potential for recovery of damages outweighs the costs we are expending on these cases.   We therefore intend to continue pursuing this litigation but there is no assurance we will continue to do so or ultimately prevail should these cases go to trial.
 
Depreciation and Amortization

We recognized depreciation expenses of $64,012 and $60,921 for the years ended December 31, 2010 and 2009, respectively, which relate primarily to the depreciation of our laboratory equipment, which makes up the vast majority of our capital equipment and spending.  Amortization expenses were $51,683 in each of 2010 and 2009.  Amortization expenses relates to the amortization of license fees paid to Los Alamos National Laboratories for the use of certain patents.

Interest expense

Interest expense totaled $20,203 and $21,878 for the years ended December 31, 2010 and 2009, respectively. Interest expense was primarily paid on loans from the Los Alamos County and the revolving draw loan with Los Alamos National Bank.

Other Income

Other Income was $0 and $3,460 for the years ended December 31, 2010 and 2009, respectively. Other income was derived primarily from refunds received from Government agencies.

Net loss

Net loss totaled ($864,881) and ($144,549), representing a net loss per share of ($0.19) and ($.03) per share for the years ended December 31, 2010 and 2009, respectively.   Included in the net loss for the years ended December 31, 2010 and December 31, 2009 were stock based compensation payments of $500,503 and $199,662, respectively.  If such non cash payments had not been incurred our net loss for the years ended December 31, 2010 would have been ($364,377) and we would have had a profit of $55,113 for the year ended December 31, 2009.
 
Results of Operations for the Nine Months ended September 30, 2011 and 2010

Revenues

Our Company had revenues totaling $416,164 and $1,016,906 for the nine months ended September 30, 2011 and 2010, respectively,   a 59.1% decrease. The decline in our revenues is primarily attributable to the fact that a number of our government contracts ended in early 2011 and were only replaced with new ones in the last quarter of 2011. Due to our current back log of government contracts, we expect that our revenues will increase in 2012.  Our revenues to date have been primarily from Federal government contracts.  Going forward, we plan to heavily market our XRpro® equipment and services and educate potential customers concerning the advantages and value propositions of the XRpro® technology.  While we are optimistic about the prospects for our Company, since this is a relatively new product offering with significantly different characteristics compared with existing equipment on the market (and we have not recognized significant revenues to date), there can be no assurance about whether or when our products will generate sufficient revenues with adequate margins in order for our Company to be profitable.
 
 
 
Cost of goods sold

Cost of goods sold decreased 65.6% to $206,167 from $600,144 for the nine months ended September 30, 2011 and 2010, respectively. Cost of goods sold is comprised primarily of direct expenses related to providing our services under government contracts.  These expenses include salary expenses directly related to research contracts, outside consultants and direct materials used on Government contracts.

Gross Profit

Gross profit was $209,997 and $416,762 and gross margin was 50.5% and 41.0% for the nine months ended September 30, 2011 and 2010, respectively.  This increase in gross margin is primarily attributable to lower payroll costs incurred in performing the government contracts in 2011.  The gross margin percentages relate to our Federal government contracts and may not be indicative of anticipated future results due to the Company’s plan to diversify its source of revenues into equipment sales and services.  

General and administrative expenses

General and administrative expenses increased 47.8% and totaled $1,475,735 and $998,569 for the nine months ended September 30, 2011 and 2010, respectively.  Payroll expenses totaled $449,216 and $250,517 in 2011 and 2010 respectively. The increase in payroll expenses is directly related to the decrease in payroll costs charged to cost of sales as there were fewer Government contracts during 2011. Stock based compensation costs, primarily related to stock options amounts to $300,128 and $240,182 in 2011 and 2010 respectively. The increase in our stock based compensation charge is primarily due to an increase in the number of options outstanding to employees. Legal expenses totaled $478,164 and $142,546 in 2011 and 2010 respectively. The increase in our legal expenses was primarily due to our funding of expenses related to our suits against Los Alamos National Security LLC. (LANS) and the Regents of the University of California as well as the Bellow litigation (see Legal Proceedings).  While the Company has negotiated a partial contingency fee agreement in the LANS case, the Company will still face significant continuing legal expenses should it continue to pursue its actions. Our legal expenses are not connected with our regular business activities and while still ongoing should be viewed as non operating expenses.  We are plaintiffs in two lawsuits and therefore to some extent we have some degree of control as to whether we will continue to fund this litigation.  At present it is our judgment that the potential for recovery of damages outweighs the costs we are expending on these cases.   We therefore intend to continue pursuing this litigation but there is no assurance we will continue to do so or ultimately prevail should these cases go to trial

Depreciation and Amortization

We recognized depreciation expenses of $49,783 and $47,994 for the nine months ended September 30, 2011 and 2010 respectively.  Depreciation expenses relate primarily to the depreciation of our laboratory equipment, which makes up the vast majority of our capital equipment and spending.  Amortization expenses were $38,763 and $38,763 for the nine months ended September 30, 2011 and 2010 respectively. Amortization expenses relates to the amortization of license fees paid to Los Alamos National Laboratories for the use of certain patents.

Interest expense
 
Interest expense totaled $12,918 and $15,058 in for the nine months ended September 30, 2011 and 2010 respectively.  Interest expense was primarily paid on loans from the Los Alamos County and the revolving draw loan with Los Alamos National Bank that was repaid in full in 2011. The reduction in interest expense was primarily due to the repayment of the revolving draw line in 2011 without drawing down on additional facilities available to us
 
Other Income

Other Income was $7,988 and $0 for the nine months ended September 30, 2011 and 2010 respectively.  Other income was derived primarily from refunds from Government agencies.

Net loss

Net loss totaled ($1,358,791) and ($683,613) or ($0.29) and ($0.15) per share for the nine months ended September 30, 2011 and 2010 respectively.  Included in the net loss for the nine months ended September 30, 2011 and September 30, 2010 were stock based compensation payments of $300,128 and $240,182, respectively.  If such non cash payments had not been incurred our net loss for the nine months ended September 30, 2011 and September 30, 2010 would have been ($1,058,663) and ($443,431), respectively.
 
 
Liquidity and Capital Resources

We have primarily financed our operations from our inception in 2003 through the sale of unregistered equity and the cash flow generated by operations.  As of September 30, 2011, our Company had cash totaling $916,653 and other current assets totaling $65,055, and total assets of $1,894,621.  We had total current liabilities of $601,875 and net working capital of $379,833. Total liabilities were $850,322 resulting in a stockholders’ equity of $1,044,299 at September 30, 2011.  
 
 
Net cash flows consumed by operating activities totaled $661,052 for the nine months ended September 30, 2011. Net cash flows used in investing activities for the same period was $48,412.  Cash flows received from financing activities totaled $1,508,207 and the overall change in cash was an increase of $798,743, of which $1,640,150 in gross proceeds was raised in a private placement which was used to repay our line of credit, repayment of a loan payable to a third party and a stockholder.

Given estimates of our Company’s future operating results and our expectations regarding the sale of our XRPRO® machines and commercial services, we believe that we have adequate financial resources to achieve cash flow break-even.  We have nevertheless included a discussion concerning the presentation of our financial statements on a going concern basis in the notes to our financial statements and our independent public accountants have included a similar discussion in their opinion on our financial statements through December 31, 2010.  

Should we not achieve our forecasted operating results or should strategic opportunities present themselves such that additional financial resources would present attractive investing opportunities for our Company, we may decide in the future to issue debt or sell our Company’s equity securities in order to raise additional cash.  There are no arrangements in place for any such financing at this time.  We cannot provide any assurances as to whether we will be able to secure any necessary financing, or the terms of any such financing transaction if one were to occur. We currently have a $750,000 funding facility available to us from the Los Alamos National Bank.  The facility expires on May 22, 2012 unless demand for repayment is made earlier and currently bears interest at a coupon of the Wall Street Journal Prime rate plus 1% with a floor of 3.25% per annum.  The loan is secured by inventory, accounts receivable and other rights to payments, instruments, documents and other chattel paper, general intangibles and fixed assets. To date, no funds have been drawn from this facility.  The loan is personally guaranteed by Benjamin Warner, our Chief Executive Officer.  The loan agreement provides that we cannot incur or assume: (i) any debt other than existing debt of the date the loan agreements were executed or accounts payable incurred in the ordinary course of business or (ii) any liens other than inconsequential lines incurred in the ordinary course of business.

As of September 30, 2011, we owed $278,134 in accordance with the terms of a Project Participation Agreement with the Incorporated County of Los Alamos that we entered into in September 2006.  The loan bears interest at a rate of 5% per annum, is for a 13 year term and required no repayments for 36 months with 120 monthly repayments commencing on September 21, 2009.

Capital Expenditures

Our current plans do not call for our Company to expend significant amounts for capital expenditures for the foreseeable future beyond a potential additional XRPRO® X-ray fluorescence microscope as well as office furniture and information technology related equipment as we add employees and sales offices to our Company.  Bruker produces the XRPRO products that we market and our corporate facilities are contracted for with third parties (and therefore do not require us to make capital purchases in this area).  

Critical Accounting Policies

Use of estimates

The preparation of these financial statements in accordance with US GAAP requires us to make estimates and judgments that affect the reported amounts of assets, liabilities, revenues and expenses, and related disclosure of contingent assets and liabilities. We continually evaluate our estimates, including those related to bad debts, inventories, recovery of long-lived assets. We base our estimates on historical experience and on various other assumptions that we believed to be reasonable under the circumstances, the results of which form the basis for making judgments about the carrying values of assets and liabilities that are not readily apparent from other sources. Any future changes to these estimates and assumptions could cause a material change to our reported amounts of revenues, expenses, assets and liabilities. Actual results may differ from these estimates under different assumptions or conditions. We believe the following critical accounting policies affect our more significant judgments and estimates used in the preparation of the financial statements. Significant estimates include the allowance for doubtful accounts, the allowance for obsolete inventory, the useful life of property and equipment and intangible assets, and assumptions used in assessing impairment of long-term assets.
 
 
Revenue recognition

Revenue sources consist of government grants, government contracts and commercial development contracts.

Revenues from government grants and contracts are for research and development purposes and are recognized in accordance with the terms of the award and the government agency. Grant revenue is recognized in one of two different ways depending on the grant. Cost reimbursement grants require us to submit proof of costs incurred that are invoiced by us to the government agency, which then pays the invoice. In this case, grant revenue is recognized during the period that the costs were incurred according to the terms of the government grant. Fixed cost grants require no proof of costs at the time of invoicing, but proof is required for audit purposes and grant revenue is recognized during the period that the costs were incurred according to the terms of the government grant. The grant revenue under these fixed costs grants is recognized using a percentage-of-completion method, which uses assumptions and estimates. These assumptions and estimates are developed in coordination with the principal investigator performing the work under the government fixed-cost grants to determine key milestones, expenses incurred, and deliverables to perform a percentage-of-completion analysis to ensure that revenue is appropriately recognized. Critical estimates involved in this process include total costs incurred and anticipated to be incurred during the remaining life of the grant.

Government contract revenue is recognized as allowable research and development expenses are incurred during the period and according to the terms of the government contract.

Commercial revenue is recognized when the service or development is delivered or upon complying with the relevant terms of the commercial agreement.

Intangible assets

a)   License Agreements

License agreements acquired by the Company are reported at acquisition value less accumulated amortization and impairments.
 
b)   Amortization

Amortization is reported in the income statement straight-line over the estimated useful life of the intangible assets, unless the useful life is indefinite. Amortizable intangible assets are amortized from the date that they are available for use. The estimated useful life of the license agreement is twenty years which is the term of the patent supporting the underlying license agreements

Assessment of an intangible asset’s residual value and useful life is performed annually.

Plant and equipment

Plant and equipment is stated at cost less accumulated depreciation.  Depreciation is computed using straight-line method over the estimated useful lives of the assets. The estimated useful lives of the assets are as follows:

Leasehold improvements                                                                    5 Years
Laboratory equipment                                                                         7 Years
Furniture and fixtures                                                                          10 Years
Computer equipment                                                                           3 Years

The cost of repairs and maintenance is expensed as incurred; major replacements and improvements are capitalized. When assets are retired or disposed of, the cost and accumulated depreciation are removed from the accounts, and any resulting gains or losses are included in income in the year of disposition.

We examine the possibility of decreases in the value of fixed assets when events or changes in circumstances reflect the fact that their recorded value may not be recoverable. We recognize an impairment loss when the sum of expected undiscounted future cash flows is less than the carrying amount of the asset. The amount of impairment is measured as the difference between the asset’s estimated fair value and its book value.

Share-Based Compensation
 
Share-based compensation cost is measured at the grant date, based on the estimated fair value of the award and is recognized as expense over the employee's requisite service period on a straight-line basis. Share-based compensation expense recognized in the consolidated statements of operations  and is based on awards ultimately expected to vest and has been reduced for estimated forfeitures. This estimate will be revised in subsequent periods if actual forfeitures differ from those estimates. We have no awards with market or performance conditions.
 
 
Net loss per share

We calculate basic earnings per share (“EPS”) by dividing our net loss by the weighted average number of common shares outstanding for the period, without considering common stock equivalents.  Diluted EPS is computed by dividing net income or net loss by the weighted average number of common shares outstanding for the period and the weighted average number of dilutive common stock equivalents, such as options and warrants.  Options and warrants are only included in the calculation of diluted EPS when their effect is dilutive.  

Contingencies

Certain conditions may exist as of the date the financial statements are issued, which may result in a loss to the Company but which will only be resolved when one or more future events occur or fail to occur. The Company’s management assesses such contingent liabilities, and such assessment inherently involves an exercise of judgment. In assessing loss contingencies related to legal proceedings that are pending against and by the Company or unasserted claims that may result in such proceedings, the Company’s management evaluates the perceived merits of any legal proceedings or unasserted claims as well as the perceived merits of the amount of relief sought or expected to be sought.
 
If the assessment of a contingency indicates that it is probable that a material loss has been incurred and the amount of the liability can be estimated, then the estimated liability would be accrued in the Company’s financial statements. If the assessment indicates that a potential material loss contingency is not probable but is reasonably possible, or is probable but cannot be estimated, then the nature of the contingent liability, together with an estimate of the range of possible loss if determinable and material would be disclosed. Loss contingencies considered to be remote by management are generally not disclosed unless they involve guarantees, in which case the guarantee would be disclosed.
 
Recent accounting pronouncements
 
For discussion of recently issued and adopted accounting pronouncements, please see Note 2 to the Caldera Pharmaceuticals financial statements included herein.  
 
DIRECTORS, EXECUTIVE OFFICERS, PRO MO TERS AND CONTROL PERSONS

Directors and Executive Officers
 
The following table sets forth the name, age and position held by each of our executive officers and directors.

Name
Age
Office(s) Held
Dr. Benjamin Warner
43
President, Chief Executive Officer, Treasurer, Director
Edward Roffman
62
Director
Jeremiel Zimmerman
62
Director

Dr. Benjamin Warner - President, Chief Executive Officer, Treasurer and Director

Since its incorporation in 2003, Dr. Warner has served as our President, Chief Executive Officer, Treasurer and a director. Before founding the Company, Dr. Warner worked in technology development, patenting, and marketing at the Los Alamos National Laboratory and in the development of “dual use” government / commercial technologies. Dr. Warner has co-developed technologies that have led to the formation of several technology companies. Dr. Warner holds a Ph.D. in Chemistry from MIT and a BS from the University of the South. Dr. Warner is the co-inventor on 30+ patents/pending patents.   After MIT, Dr. Warner joined Los Alamos National Laboratory where he held the position of Project Leader for National Security Programs from 2000 until 2004.

Dr. Warner has won numerous awards from Los Alamos National Laboratory for his commercialization and patenting work, including the Distinguished Licensing Award, the Distinguished Entrepreneurial Award, the Distinguished Patent Award, and the Federal Laboratory Consortium Distinguished Service Award. Jointly with LANL, Caldera Pharmaceuticals won the 2007 Federal Laboratory Consortium Award for Excellence in Technology Transfer and an R&D100 Award. Caldera has won multiple Technology Ventures Corporation awards for top technology companies in New Mexico.

Dr. Warner has been associated with the Company since its inception and brings to the board extensive knowledge about our business operations and in particular our licenses and products.     Having developed our technology Dr. Warner brings to the board significant strategic, business and financial experience related to the business and financial issues facing pharmaceutical companies and particularly our company. Dr. Warner has a broad understanding of the operational, financial and strategic issues facing pharmaceutical companies. 
 
 
Ed Roffman, Director  

Mr. Roffman has been a director since December 2011. Mr. Roffman   served as Chief Financial Officer of Red Mile Entertainment, Inc. from January 2005 until April 2006 and at Fluent Entertainment, Inc. from February 2003 to December 2004. Both companies are consumer software developers and publishers. Mr. Roffman has also been a principal of Creekside, LLC, a consulting firm which specializes in the software, internet and consumer products industries. From August 1995 to January 1999, Mr. Roffman served as Chief Financial Officer and Chief Operating Officer at Palladium Interactive, Inc., a consumer software company. Mr. Roffman served on the board and audit committee of Silverstar Holdings (NASDAQ: SSTR) a publisher and developer of interactive entertainment software and Adex Media (NASDAQ: ADXM) an Internet marketing and lead generation publisher and developer, manufacturer, and marketer of consumer products and Westinghouse Solar, Inc., (formerly Akeena Solar), a designer and distributor of solar modules (NASDAQ).  Mr. Roffman is a CPA with over 30 years of experience in accounting and finance. Mr. Roffman earned a BBA in accounting from Temple University.
 
Mr. Roffman’s achievements in financial and accounting matters, his overall business understanding, as well as his familiarity and knowledge regarding public companies and corporate governance issues that public companies face make him an ideal board candidate.

Jeremiel Zimmerman – Director

Mr. Zimmerman co-founded Caldera and has been a director since August 2005.    Mr. Zimmerman has been a commodity trading advisor and a drafter of newsletter regarding commodities and other securities since 1991.  He currently prepares for AMMO Trading Group a news letter with a daily analysis of the e-Mini S&P in addition to hosting an Internet discussion group regarding commodity futures trading .  He is registered as a Series 3 broker with the NFA

Mr. Zimmerman’s understanding of the financial markets as well as his overall business understanding make him an attractive board member.
 
Two of our directors, Dr. Benjamin Warner and Jeremiel Zimmerman, are first cousins, once removed.
 
Term of Office
 
Our directors hold office until the next annual general meeting of our shareholders or until removed from office in accordance with our bylaws.  Our officers are appointed by our board of directors and hold office until removed by the board.
 
EXECUTIVE COMPENSA TION AND OTHER INFORMATION
 
Executive Compensation
 
The following table sets forth all compensation awarded, earned or paid for services rendered to our principal executive officer, principal financial officer and each executive officer whose compensation exceeded $100,000 during each of the fiscal years ended December 31, 2011 and 2010.

Summary Compensation Table

Name and Principal Position
 
Year
   
Salary ($)
   
Bonus ($)
   
Option Awards ($)
   
Non-Equity Incentive Plan Compensation ($)
   
Nonqualified
Deferred
Compensation
Earnings ($)
   
All Other Compensation ($)
   
Total ($)
 
Dr. Benjamin Warner,
President and Chief Executive Officer, Treasurer
   
2011
2010
     
199,700
193,442
      -       -       -       -      
24,196
28,917
     
223,896
222,359
 
                                                                 
Lori Peterson
Chief Operating Officer*
   
2011
  2010
     
144,000
119,641
      -       -       -       -      
12,319
7,933
     
156,319
127,547
 

*Lori Peterson resigned as Chief Operating Officer in November 2011.
 
 
Employment Agreements
 
On October 25, 2006, we entered into an Employment Agreement with Dr. Benjamin Warner pursuant to which Dr. Warner was appointed our Chief Executive Officer to serve in such role until the agreement is terminated.  For such services, the agreement provides that Dr. Warner is to be paid a base salary of $200,000 in addition to certain bonuses and benefits.  If Dr. Warner is terminated for cause (as defined in the agreement), he is only entitled to accrued amounts owed to him; however if he is terminated without cause he is entitled to three months base salary and accrued benefits.

From 2009 through 2011, Lori Peterson served as our Chief Operating Officer.  She currently serves as our Program Manager/ Molecular Epidemiologist.   On August 17, 2006, we entered into an Employment Agreement with Lori Peterson to serve as our Program Manager/ Molecular Epidemiologist until the agreement is terminated.  For such services, the agreement provides that Ms. Peterson is to be paid a base salary of $100,000 in addition to certain bonuses and benefits.
 
Outstanding Equity Awards at Fiscal Year End
 
The table below summarizes all unexercised options, stock that has not vested, and equity incentive plan awards for each named executive officer as of December 31, 2011.
 
OUTSTANDING EQUITY AWARDS AT FISCAL YEAR-END
 
   
OPTION AWARDS
   
STOCK AWARDS
 
 
 
 
 
 
 
 
 
Name
 
 
Number of Securities Underlying Unexercised Options
(#)
Exercisable
   
Number of Securities Underlying Unexercised Options
 (#)
Unexercisable
   
 Equity Incentive  
Plan Awards: Number of Securities Underlying Unexercised Unearned Options
(#)
   
 
 
 
 
Option Exercise  Price
($)
   
 
 
 
 
 
 
 
Option
Expiration Date
   
Number of
Shares or
Units of Stock
That Have
 Not Vested
(#)
   
Market Value of Shares or Units of Stock That Have Not Vested
($)
   
Equity
Incentive  
Plan Awards:  
Number of
Unearned  
Shares,
Units or Other
Rights That
Have  
Not Vested
(#)
   
Equity Incentive Plan Awards: Market or Payout Value of Unearned Shares, Units or Other Rights That Have Not  Vested
(#)
 
Dr. Benjamin Warner
   
-
     
-
     
-
     
-
     
-
     
-
     
-
     
-
      -  
                                                                       
Lori Peterson
   
50,000
     
-
     
-
     
5.71
     
8/16
     
-
     
-
     
-
      -  
     
220,000
                     
1.10
 
2
 
2/21
                               
 
 
Director Compensation
 
The table below summarizes all compensation of our directors for the year ended December 31, 2011.
 
DIRECTOR COMPENSATION*
 
 
Name
 
Fees Earned or
Paid in Cash
($)
   
 
Stock Awards
($)
   
 
 
Option Awards
($)
   
Non-Equity Incentive Plan Compensation
($)
   
Non-Qualified Deferred Compensation Earnings
($)
 
All
Other Compensation
($)
 
 
 
 
Total
($)
 
Dr. Benjamin Warner
   
0
     
0
     
0
     
0
     
0
 
0
   
0
 
                                                   
Lori Peterson**    
0
     
0
     
0
     
0
     
0
 
0
   
0
 
                                                   
Jeremiel Zimmerman
   
0
     
0
     
0
     
0
     
0
 
0
   
0
 

* Does not include compensation received for services provided as executive officers
**Lori Peterson resigned from the Board of Directors on November 15, 2011, effective upon the election of an outside director to replace her.

Corporate Governance
 
Leadership Structure
 
Our Chief Executive Officer Dr. Benjamin Warner also serves as Chairman of the Board. Our Board of Directors does not have a lead independent director. Our Board of Directors has determined that its leadership structure was appropriate and effective for the Company given its stage of operations.  
 
Board Committees
 
We presently do not have an audit committee, compensation committee or nominating committee or committee performing similar functions, as our management believes that until this point it has been premature at the early stage of our management and business development to form an audit, compensation or nominating committee.
 
Director Independence
 
The Board has determined that Messrs. Zimmerman and Rothman are “independent” in accordance with the requirements of Rule 10A-3 under the Exchange Act.
 
SECURITY OWNERSHIP OF CERTAIN B ENE FICIAL OWNERS AND MANAGEMENT
 
The following table sets forth, as of February 8, 2012, information with respect to the securities holdings of: (i) our officers and directors; and (ii) all persons (currently none) which, pursuant to filings with the SEC and our stock transfer records, we have reason to believe may be deemed the beneficial owner of more than five percent (5%) of our common stock.  The securities "beneficially owned" by an individual are determined in accordance with the definition of "beneficial ownership" set forth in the regulations promulgated under the Exchange Act and, accordingly, may include securities owned by or for, among others, the spouse and/or minor children of an individual and any other relative who resides in the same home as such individual, as well as other securities as to which the individual has or shares voting or investment power or which each person has the right to acquire within 60 days through the exercise of options or otherwise.  Beneficial ownership may be disclaimed as to certain of the securities.  This table has been prepared based on the number of shares outstanding totaling 4,291,620, adjusted individually as shown below.
 

 
Name and Address of Beneficial Owner 
 
Amount and
Nature of Beneficial Ownership
   
Percentage
of Class
Beneficially
Owned  (1)
 
             
Ed Roffman
    20,000       *  
                 
Dr. Benjamin Warner(2)
    3,236,570       74.5 %
                 
Jeremiel Zimmerman
    104,000       2.4 %
                 
All directors and executive officers as a group (3 persons)
    3,360,570       77.4 %
 
* Less than 1%
 
(1)  
Percentage of class beneficially owned is calculated by dividing the amount and nature of beneficial ownership by the total shares of common stock outstanding plus the shares subject to warrants and options that are currently exercisable or exercisable within 60 days of February 1, 2012.  
(2)  
Includes 25,035 shares of Series A preferred stock which is convertible into 25,035 shares of common stock.  Also includes warrants to purchase 25,035 shares of common stock. The Series A preferred stock and the warrants are held by jointly by Dr. Warner and his wife, Ellen McBee.
 
SELLING ST OC KHOLDERS
 
The shares to be offered by the selling security holders were issued in private placement transactions by us, each of which was exempt from the registration requirements of the Securities Act. The shares offered hereby are “restricted” securities under applicable federal and state securities laws and are being registered under the Securities Act, to give the selling security holders the opportunity to publicly sell these shares. This prospectus is part of a registration statement on Form S-1 filed by us with the Securities and Exchange Commission under the Securities Act covering the resale of such shares of our common stock from time to time by the selling security holders. No estimate can be given as to the amount or percentage of our common stock that will be held by the selling security holders after any sales made pursuant to this prospectus because the selling security holders are not required to sell any of the shares being registered under this prospectus. The following table assumes that the selling security holders will sell all of the shares listed in this prospectus.
  
The following table sets forth the name of each person who is offering for resale shares of common stock covered by this prospectus, the beneficial ownership of each selling security holder, the number of shares of common stock that may be sold in this offering and the number of shares of common stock each will own after the offering, assuming they sell all of the shares offered. The term “selling security holder” or “selling security holders” includes the stockholders listed below and their respective successors. Beneficial ownership is determined in accordance with the rules of the Securities and Exchange Commission and generally includes voting or investment power with respect to securities.
 

 
Shareholder and Name of Person Controlling
 
Number of Shares Before Offering
   
Number of Shares Offered
   
Date Acquired
   
Amount of Shares Owned After Offering
   
Percent of Shares Held After Offering
 
                               
Eight Family Trust
    27,000 (1)     27,000    
3/22/2011
      0       0  
Chang-Tai Hsieh
    19,756 (2)     19,756    
3/24/2011
      0       0  
Joseph Amato Revocable Trust
    52,632 (3)     52,632    
4/7/2011
      0       0  
Sin Fa Wang and Mei Wang
    17,544 (4)     17,544    
4/11/2011
      0       0  
S/L Trilling Trust
    35,088 (5)     35,088    
4/14/2011
      0       0  
Douglas Jensen
    27,500 (6)     27,500    
4/18/2011
      0       0  
Mark Litwin
    35,088 (7)     35,088    
4/26/2011
      0       0  
Robert S. Colman
    17,544 (8)     17,544    
4/27/2011
      0       0  
2030 Investors LLC/401K Plan
    50,000 (9)     50,000    
5/12/2011
      0       0  
Sarah Abrams
    42,544 (10)     42,544    
5/12/2011
      0       0  
Matthew Abrams
    92,544 (11)     92,544    
5/12/2011
      0       0  
Joseph W. and Patricia G. Family Trust
    158,220 (12)     158,220    
5/16/2011
      0       0  
James Jensen
   
70,000
(13)    
70,000
   
6/7/2011
      0       0  
Chan Kei Blu
    52,632 (14)     52,632    
9/8/2011
      0       0  
Louitt & V. Hannan, Inc. Salary Deferral Plan FBO J. Thomas Hannan
    17,544 (15)     17,544    
9/13/2011
      0       0  
George Mainas
    17,544 (16)     17,544    
10/13/2011
      0       0  
Saunders and Diane Kohn
    70,000 (17)     70,000    
10/17/2011
      0       0  
David Steinhardt and Tobi B Richman Steinhardt Trust
    20,176 (18)     20,176    
1/22/2012
      0       0  
Los Alamos National Security, LLC
    157,500 (19)     157,500       (19 )     0       0  
Richard Scott Lane
    73,571 (20)     73,571       (20 )     0       0  
Aldermon Holdings
    17,500 (21)     17,500       (21 )     0       0  
TRV, LLC
    8,750       8,750    
4/6/2006
      0       0  
David Clark
    8,750       8,750    
5/9/2006
      0       0  
CO 51 AIC Holdings LLC
    87,565       87,565    
9/22/2006
      0       0  
Jack Warner
    10,000       10,000    
10/10/2006
      0       0  
Cirrus Advisors, Inc.
    26,250 (22)     26,250       (22 )     0       0  
Michael Lyon Profit Sharing Plan
    25,715 (22)     25,715       (22 )     0       0  
Susan Gerard
    26,250 (22)     26,250       (22 )     0       0  
Susan Gerard IRA
    25,714 (22)     25,714       (22 )     0       0  
Nathan H. Zahler
    2,418 (23)     2,418       (23 )     0       0  
Gregg Rzepczynski
    2,459 (24)     2,459       (24 )     0       0  
Emelia A. Solomon
    1,830 (25)     1,830       (25 )     0       0  
Pratima Bharti
    636 (26)     636       (26 )     0       0  
First South Africa Management
    100,000 (27)     100,000       (27 )    
0
      0  
Total
   
1,398,264
     
1,398,264
             
0
     
0
 
                                         
                                         

(1)  
Includes 13,500 shares of common stock which are convertible upon conversion of the Series A Preferred Stock and 13,500 shares of common stock which are issuable upon exercise of the warrant
(2)  
Includes (i) 8,772 shares of common stock which are convertible upon conversion of the Series A Preferred Stock; (ii) 8,772 shares of common stock which are issuable upon exercise of the warrant; (iii) 324 shares of common stock issued upon exercise stock options that were exercised on March 3, 2011; (iv) 420 shares of common stock issued upon exercise stock options that were exercised on March 17, 2011; (v) 420  shares of common stock issued upon exercise stock options that were exercised on March 31, 2011; (vi) 419  shares of common stock issued upon exercise stock options that were exercised on April 14, 2011; (vii) 420  shares of common stock issued upon exercise stock options that were exercised on April 28, 2011; and (viii) 209 stock options that were exercised on May 26, 2011.
(3)  
 Includes 26,316 shares of common stock which are convertible upon conversion of the Series A Preferred Stock and 26,316 shares of common stock which are issuable upon exercise of the warrant
(4)  
Includes 8,772 shares of common stock which are convertible upon conversion of the Series A Preferred Stock and 8,772 shares of common stock which are issuable upon exercise of the warrant
(5)  
Includes 17,544 shares of common stock which are convertible upon conversion of the Series A Preferred Stock and 17,544 shares of common stock which are issuable upon exercise of the warrant
(6)  
Includes (i) 5,000 shares of common stock which are convertible upon conversion of the Series A Preferred Stock; (ii) 5,000 shares of common stock which are issuable upon exercise of the warrant; (iii) 10,500 shares of common stock that were issued on February 6, 2006; and (iv) 7,000 shares of common stock that were issued on July 19, 2006.
(7)  
Includes 17,544 shares of common stock which are convertible upon conversion of the Series A Preferred Stock and 17,544 shares of common stock which are issuable upon exercise of the warrant
(8)  
Includes 8,772 shares of common stock which are convertible upon conversion of the Series A Preferred Stock and 8,772 shares of common stock which are issuable upon exercise of the warrant
(9)  
Includes 25,000 shares of common stock which are convertible upon conversion of the Series A Preferred Stock and 25,000 shares of common stock which are issuable upon exercise of the warrant
 
 
 
(10)  
Includes: (i) 8,772 shares of common stock which are convertible upon conversion of the Series A Preferred Stock; (ii) 8,772 shares of common stock which are issuable upon exercise of the warrant; and (iii) 25,000 shares of common stock that were issued on October 26, 2010 for services rendered..
(11)  
Includes (i) 8,772 shares of common stock which are convertible upon conversion of the Series A Preferred Stock;  (ii) 8,772 shares of common stock which are issuable upon exercise of the warrant; (iii) 75,000 shares of common stock that were issued on October 26, 2010 for services rendered.
(12)  
Includes (i) 43,860 shares of common stock which are convertible upon conversion of the Series A Preferred Stock; (ii) 43,860 shares of common stock which are issuable upon exercise of the warrant; and (ii) 70,500 shares of common stock that were issued on October 26, 2010 for services rendered.
(13)  
Includes (i) 35,000 shares of common stock which are convertible upon conversion of the Series A Preferred Stock; (ii) 35,000 shares of common stock which are issuable upon exercise of the warrant.
(14)  
Includes 26,316 shares of common stock which are convertible upon conversion of the Series A Preferred Stock and 26,316 shares of common stock which are issuable upon exercise of the warrant
(15)  
Includes 8,772 shares of common stock which are convertible upon conversion of the Series A Preferred Stock and 8,772 shares of common stock which are issuable upon exercise of the warrant
(16)  
Includes 8,772 shares of common stock which are convertible upon conversion of the Series A Preferred Stock and 8,772 shares of common stock which are issuable upon exercise of the warrant
(17)  
Includes 35,000 shares of common stock which are convertible upon conversion of the Series A Preferred Stock and 35,000 shares of common stock which are issuable upon exercise of the warrant
(18)  
Includes 10,088 shares of common stock which are convertible upon conversion of the Series A Preferred Stock and 10,088 shares of common stock which are issuable upon exercise of the warrant.
(19)  
  Shares issued on June 15, 2006 in connection with a license agreement.
(20)  
Includes (i) 35,000 shares of common stock that were issued on January 23, 2006; and (ii) 38,571 shares of common stock that were issued on October 22, 2010 in connection with a settlement agreement.
(21)  
Includes (i) 8,750 shares of common stock that were issued on March 27, 2006; and (ii) 8,750 shares of common stock that were issued on May 19, 2006.
(22)  
Includes (i) 52,500 shares of common stock that were issued on August 1, 2006 for services rendered of which 26,250 shares were transferred to Cirrus Advisors, Inc. a company which Mr. Lyons has a controlling interest and 26,250 were transferred on August 3, 2011 to Susan Gerard as part of a divorce settlement; and (ii) 51,429 shares of common stock that were issued on October 22, 2010 of which 25,715 shares were transferred to the Michael T. Lyon Profit Sharing Plan and 25,714 shares were transferred on August 3, 2011 to the Susan Gerard IRA as part of a divorce settlement between Lyon and Gerard.
(23)  
Includes (i) 381 shares of common stock issued upon exercise stock options that were exercised on March 3, 2011; (ii) 453 shares of common stock issued upon exercise stock options that were exercised on March 17, 2011; (iii) 453 shares of common stock issued upon exercise stock options that were exercised on March 31, 2011; (iv) 452 shares of common stock issued upon exercise stock options that were exercised on April 14, 2011; (v) 453 shares of common stock issued upon exercise stock options that were exercised on April 28, 2011; and (vi) 226 shares of common stock issued upon exercise stock options that were exercised on May 26, 2011.
(24)  
Includes (i) 326 shares of common stock issued upon exercise stock options that were exercised on March 3, 2011; (ii) 474 shares of common stock issued upon exercise stock options that were exercised on March 17, 2011; (iii) 474 shares of common stock issued upon exercise stock options that were exercised on March 31, 2011; (iv) 474 shares of common stock issued upon exercise stock options that were exercised on April 14, 2011; (v) 474 shares of common stock issued upon exercise stock options that were exercised on April 28, 2011; and (vi) 237 shares of common stock issued upon exercise stock options that were exercised on May 26, 2011.
(25)  
Includes (i) 333 shares of common stock issued upon exercise stock options that were exercised on March 3, 2011; (ii) 333 shares of common stock issued upon exercise stock options that were exercised on March 17, 2011; (iii) 333 shares of common stock issued upon exercise stock options that were exercised on March 31, 2011; (iv) 332 shares of common stock issued upon exercise stock options that were exercised on April 14, 2011; (v) 333 shares of common stock issued upon exercise stock options that were exercised on April 28, 2011; and (vi) 166 shares of common stock issued upon exercise stock options that were exercised on May 26, 2011.
(26)  
Includes (i) 178 shares of common stock issued upon exercise stock options that were exercised on March 17, 2011; (ii) 154 shares of common stock issued upon exercise stock options that were exercised on March 31, 2011; (iii) 165 shares of common stock issued upon exercise stock options that were exercised on April 14, 2011; and (iv) 139 shares of common stock issued upon exercise stock options that were exercised on April 28, 2011.
(27)  
Shares issued on December 2011 and February 2012  for services rendered.
 
 
 
PLAN OF DIS TR IB UTION

Each selling security holder of our common stock and any of their transferees, pledgees, assignees, donees, and successors-in-interest may, from time to time, sell any or all of their shares of common stock on the stock exchange on which they are listed on the OTC Bulletin Board, if quoted on the OTC Bulletin Board, or in private transactions. These sales will be at a fixed price of $5.00 per share until the shares of common stock are listed on the OTC Bulletin Board, after which sales may be at prevailing market prices or privately negotiated prices. Selling security holders may use any one or more of the following methods when selling shares:
 
ordinary brokerage transactions and transactions in which the broker-dealer solicits purchasers;
   
block trades in which the broker-dealer will attempt to sell the shares as agent but may position and resell a portion of the block as principal to facilitate the transaction;
   
purchases by a broker-dealer as principal and resale by the broker-dealer for its account;
   
an exchange distribution in accordance with the rules of the applicable exchange;
   
privately negotiated transactions;
   
broker-dealers may agree with the selling security holders to sell a specified number of such shares at a stipulated price per share;
   
a combination of any such methods of sale; or
   
any other method permitted pursuant to applicable law.
 
The selling security holders may also sell shares under Rule 144 under the Securities Act, if available, rather than under this prospectus.
 
Broker-dealers engaged by the selling security holders may arrange for other brokers-dealers to participate in sales. Broker-dealers may receive commissions or discounts from the selling security holders (or, if any broker-dealer acts as agent for the purchaser of shares, from the purchaser) in amounts to be negotiated. Each selling security holder does not expect these commissions and discounts relating to its sales of shares to exceed what is customary in the types of transactions involved.
 
The selling security holders and any broker-dealers or agents that are involved in selling the shares of common stock may be deemed to be “underwriters” within the meaning of the Securities Act in connection with such sales. In such event, any commissions received by such broker-dealers or agents and any profit on the resale of the shares purchased by them may be deemed to be underwriting commissions or discounts under the Securities Act. Because selling security holders may be deemed to be underwriters within the meaning of the Securities Act, they will be subject to the prospectus delivery requirements of the Securities Act. Discounts, concessions, commissions and similar selling expenses, if any, that can be attributed to the sale of common stock will be paid by the selling security holders and/or the purchasers. Each selling security holder has represented and warranted to us that it acquired the securities subject to this registration statement in the ordinary course of such selling security holder’s business and, at the time of its purchase of such securities such selling security holder had no agreements or understandings, directly or indirectly, with any person to distribute any such securities.
 
There is no underwriter or coordinating broker acting in connection with the proposed sale of the resale shares by the selling security holders. We are required to pay certain fees and expenses incurred by us incident to the registration of the shares. We have agreed to indemnify the selling security holders against certain losses, claims, damages and liabilities, including liabilities under the Securities Act.
 
The selling securityholders may from time to time pledge or grant a security interest in some or all of the shares owned by them and, if they default in the performance of their secured obligations, the pledgees or secured parties may offer and sell shares of common stock from time to time under this prospectus, or under an amendment to this prospectus under Rule 424(b)(3) or other applicable provision of the Securities Act amending the list of selling securityholders to include the pledgee, transferee or other successors-in-interest as selling security holders under this prospectus. Upon our company being notified in writing by a selling security holder that any material arrangement has been entered into with a broker-dealer for the sale of common stock through a block trade, special offering, exchange distribution or secondary distribution or a purchase by a broker or dealer, a supplement to this prospectus will be filed, if required, pursuant to Rule 424(b) under the Securities Act, disclosing (i) the name of each such selling securityholder and of the participating broker-dealer(s), (ii) the number of shares involved, (iii) the price at which such the shares of common stock were sold, (iv) the commissions paid or discounts or concessions allowed to such broker-dealer(s), where applicable, (v) that such broker-dealer(s) did not conduct any investigation to verify the information set out or incorporated by reference in this prospectus, and (vi) other facts material to the transaction. In addition, upon our company being notified in writing by a selling securityholder that a donee or pledgee intends to sell more than 500 shares of common stock, a supplement to this prospectus will be filed if then required in accordance with applicable securities law.
 
 
 
Under applicable rules and regulations under the Exchange Act, any person engaged in the distribution of the resale shares may not simultaneously engage in market making activities with respect to our common stock for a period of two business days prior to the commencement of the distribution. In addition, the selling security holders will be subject to applicable provisions of the Exchange Act and the rules and regulations thereunder, including Regulation M, which may limit the timing of purchases and sales of shares of our common stock by the selling security holders or any other person. We will make copies of this prospectus available to the selling securityholders and have informed them of the need to deliver a copy of this prospectus to each purchaser at or prior to the time of the sale.
 
CERTAIN RELATIONSHIPS AND RELATED TRANSACTIONS
 
Our Chief Executive Officer is a guarantor on our revolving loan from Los Alamos National Bank, pursuant to which there is currently no outstanding amount.

During the year ended December 31, 2010 we had an outstanding loan from our Chief Executive Officer of $77,600.  At April 30, 2011 the loan amount was $102,600.  The loan was not evidenced by a written instrument, did not accrued interest and had no fixed repayment terms.  In April 2011, the amounts owed under the loan were exchanged for 18,000 additional shares of our Series A Preferred Stock and a warrant exercisable for 18,000 shares of our common stock.

DESCRIPTION OF SECURITIES
 
General

Following the consummation of the Offering, assuming that the Offering is fully subscribed, the Company will have 4,291,620 shares of common stock outstanding.  The Company currently has outstanding 4,291,620 shares of Common Stock, 341,607 shares of Series A convertible stock outstanding, warrants exercisable for 399,406 shares of common stock and options exercisable for 518,445 shares of common stock.

Preferred Stock

The Company is authorized to issue 500,000 shares of Series A preferred stock and currently has 341,607 Shares of Series A preferred stock outstanding.

The preferred stock has the following designations, preferences, and rights.

Dividend Rights. Holders of Shares of Series A preferred stock are entitled to receive a dividend of $0.46 for each share of Series A preferred stock on January 1 of each year (subject to pro-rations for any short year) payable in (i) cash; or (ii) fully paid and non-assessable shares of Common Stock of the Company at a price of $5.70 per Common Share, at the option of the holder. Holders shall be entitled to additional dividends only when, as and if declared by the Board of Directors of the Company.

Voting Rights. On any matter presented to the common stockholders of the Company for their action or consideration at any meeting of stockholders of the Company (or by written consent of the stockholders in lieu of a meeting), each holder of outstanding Shares of Series A preferred stock is entitled to cast one vote for each share of Series A preferred stock held by such holder as of the record date for determining Stockholders entitled to vote on such matter. Except as provided by law, holders of Series A preferred stock shall vote together with holders of the Common Stock of the Company as a single class.

Liquidation Rights. In the event of any termination, liquidation, dissolution or winding up of the Company either voluntary or involuntary (a “Liquidation Event”), the holders of Shares of Series A preferred stock are entitled to be paid out of the assets of the Company available for distribution to its stockholders before any payment shall be made to the holders of Common Stock by reason of their ownership thereof, an amount per share equal to the greater of: (i) $5.70 per share, plus any dividends declared but unpaid thereon, or (ii) such amount per share as would have been payable had all shares of Series A preferred stock been converted into Common Stock immediately prior to such Liquidation Event.  If upon any such Liquidation Event the assets of the Company available for distribution to its stockholders shall be insufficient to pay the holders of shares of Series A preferred stock the full amount to which they shall be entitled under their liquidation rights, the holders of shares of Series A preferred stock shall share ratably in any distribution of the assets available for distribution in proportion to the respective amounts which would otherwise be payable in respect of the shares held by them upon such distribution if all amounts payable on or with respect to such shares were paid in full.

Conversion Rights

Voluntary Conversion . Holders of Series A preferred stock may, at its election, convert each share of Series A preferred stock into that number of fully paid and non-assessable shares of Common Stock (or such other equity security of the Company for which all of its Common Stock has been exchanged or into which all of its Common Stock has been converted) equal to $5.70 per share.
 
A utomatic (Mandatory) Conversion . Ten (10) trading days after delivery to the holders of written notice of conversion by the Company, each share of Series A preferred stock then outstanding shall, by virtue of such conditions and without any action on the part of a holder thereof, be deemed automatically converted into one (1) fully paid and non-assessable share of Common Stock (or such other equity security of the Company for which all of its Common Stock has been exchanged or into which all of its Common Stock has been converted), provided that the volume weighted average closing price of the Company’s Common Stock over the ten (10) trading days immediately preceding the date of the Company’s Notice is at least $10.00 per share.
 
 
Redemption Rights

Voluntary Redemption . At any time after the date that the Company receives net cash proceeds of at least three million ($3,000,000) from litigation proceedings against the Managers of Los Alamos National Laboratory, a holder of Series A preferred stock may, at its election, redeem each share of Series A preferred stock at a price of $7.41 for each share of Series A preferred stock.

Involuntary Redemption . Thirty (30) days after delivery to the holders of written notice of redemption by the Company (the “Company’s Redemption Notice”) each share of Series A preferred stock then outstanding shall, by virtue of such conditions and without any action on the part of a holder thereof, be redeemed at a price of $7.41 for each share of Series A preferred stock.

Registration Rights . Not less than twenty one (21) days before Company files a Registration Statement (the “Company’s Registration Notice”), whether or not for sale for Company’s own account, on a form and in a manner that would permit registration of registrable securities, the Company shall deliver to holder written notice of intent to file such Registration Statement. Holder may, at its election, elect to include the underlying shares of Common Stock from such holder’s shares of Series A preferred stock in such Registration Statement.

Common Stock

We are authorized to issue 50,000,000 shares of common stock, of which 4,291,620 are issued and outstanding.

Dividend Rights . The holders of the Common Stock are entitled to receive such dividends as may be declared from time to time by the Company’s Board of Directors out of funds legally available therefore. The sole source of funds available for the payment of dividends will be from any excess funds of the Company. The Company does not believe that there will be excess funds for the foreseeable future.

Voting Rights . The holders of the Common Stock are entitled to one vote per share on all matters to be voted upon by the Company’s stockholders and do not have cumulative voting rights in the election of directors.

Redemption and No Pre-emptive Rights . The Common Stock is not subject to redemption and stockholders of the Company do not have pre-emptive rights.

Liquidation Rights . Upon any Liquidation Event, after the payment of all debts and preferential amounts required to be paid to the holders of Shares of Series A preferred stock, the remaining assets of the Company available for distribution to its stockholders shall be distributed among the holders of shares of Common Stock, pro rata based on the number of shares held by each such holder.

Warrants
 
As of the date hereof there are warrants exercisable for 399,406 shares of common stock outstanding.  Of such warrants, warrants exercisable for: (i) 334,571 shares of common stock were issued to investors in private placements in connection with the issuance of our Series A preferred stock; (ii) 42,800 shares of common stock were issued as fees in connection with the private placement; (iii) 15,000 shares of common stock were issued as fees for services and (iv) 25,035 shares of common stock were issued to Benjamin Warner in partial exchange for amounts owed to him.  The warrants, except for the 15,000 warrants issued as fees for services, which are exercisable at $2.00 per share, are exercisable at a price of $5.70 per share for a period of five years from issuance.
 
Options
 
As of the date hereof, there are options exercisable for 518,445 shares of our common stock issued under the 2005 Stock Option Plan..  All of the options were issued in consideration with the performance of services. All of the options have a ten year life with the exception of one option exercisable for 250 shares of common stock issued in August 2008 that has a 4 year life and three options issued in 2011 that have a two year life. All of the options are exercisable at a price of $5.71 per share with the exception of two options granted in 2005 which are exercisable for an aggregate of $30,000 shares of common stock at an exercise price of $2.00 per share and one option issued in February 2011 exercisable for 220,000 shares of common stock of at an exercise price of $1.10 per share. Options exercisable for 478,570 shares of common stock are vested, and the remaining options fully vest at various times throughout 2012 and 2013. In accordance with the terms of the 2005 Stock Option Plan options granted to employees that are not vested at the time of termination of employment shall terminate upon such termination and all options vested at the time of termination are exercisable for an additional one year from the date of termination unless otherwise extended by the Board of Directors.
 
Transfer Agent and Registrar
 
Our transfer agent and registrar is Corporate Stock Transfer, Inc., 3200 Cherry Creek Drive South, Suite 430, Denver, Colorado 80209.
 
 
EXP ERT S

The consolidated financial statements of Caldera Pharmaceuticals, Inc. as of December 31, 2010 and 2009 and for the year ended December 31, 2010 included in this Preliminary Prospectus and in the Registration Statement have been so included in reliance on the reports of Sherb & Co., an independent registered public accounting firm, appearing elsewhere herein and in the Registration Statement, given on the authority of said firm as experts in auditing and accounting.
 
DISCLOSURE OF COMMISSION POSI TION OF INDEMNIFICATION FOR SECURITIES ACT LIABILITIES

Pursuant to our Second Amended and Restated Articles of Incorporation, our Board of Directors may issue additional shares of common or preferred stock. Any additional issuance of common stock or the issuance of preferred stock could have the effect of impeding or discouraging the acquisition of control of us by means of a merger, tender offer, proxy contest or otherwise, including a transaction in which our stockholders would receive a premium over the market price for their shares, and thereby protects the continuity of our management.  Specifically, if in the due exercise of its fiduciary obligations, the Board of Directors was to determine that a takeover proposal was not in our best interest, shares could be issued by the Board of Directors without stockholder approval in one or more transactions that might prevent or render more difficult or costly the completion of the takeover by:

·  
diluting the voting or other rights of the proposed acquirer or insurgent stockholder group;
·  
putting a substantial voting block in institutional or other hands that might undertake to support the incumbent board of directors; or
·  
effecting an acquisition that might complicate or preclude the takeover.
 
The Delaware Corporations and Associations Act (“Delaware Corporate Law”), with certain exceptions, permits a Delaware corporation to indemnify a present or former director or officer of the corporation (and certain other persons serving at the request of the corporation in related capacities) for liabilities, including legal expenses, arising by reason of service in such capacity if such person shall have acted in good faith and in a manner he reasonably believed to be in, or not opposed, to the best interests of the corporation, and in any criminal proceeding if such person had no reasonable cause to believe his conduct was unlawful. However, in the case of actions brought by or in the right of the corporation, no indemnification may be made with respect to any matter as to which such director or officer shall have been adjudged liable, except in certain limited circumstances.
 
Our Second Amended and Restated Articles of Incorporation provide that we shall indemnify our directors and executive officers to the fullest extent now or hereafter permitted by Delaware Corporate Law. The indemnification provided by Delaware Corporate Law and our Second Amended and Restated Certificate of Incorporation is not exclusive of any other rights to which a director or officer may be entitled.  The general effect of the foregoing provisions may be to reduce the circumstances under which an officer or director may be required to bear the economic burden of the foregoing liabilities and expense.
 
We may also purchase and maintain insurance for the benefit of any director or officer that may cover claims for which we could not indemnify such person.
 
Insofar as indemnification for liabilities arising under the Securities Act of 1933 (the “Securities Act”) may be permitted to our directors, officers and controlling persons, we have been advised that, in the opinion of the SEC, such indemnification is against public policy as expressed in the Securities Act and is, therefore, unenforceable.
 
In the event that a claim for indemnification against such liabilities is asserted by one of our directors, officers, or controlling persons in connection with the securities being registered, we will, unless in the opinion of our legal counsel the matter has been settled by controlling precedent, submit the question of whether such indemnification is against public policy to court of appropriate jurisdiction. We will then be governed by the court's decision.
 
LEGAL MATTERS
 
The validity of our common stock offered hereby will be passed upon for us by Gracin & Marlow, LLP, New York, New York.

 
WHERE YOU CAN FIN D MORE INFORMATION
 
We have filed with the SEC a registration statement on Form S-1 under the Securities Act for the common stock offered under this prospectus. It is our intent to become a reporting company under the Exchange Act, upon effectiveness of this prospectus. You may obtain reports, proxy statements and other information filed by Caldera Pharmaceuticals, Inc. with the SEC at the SEC’s Public Reference Room at 100 F Street, N.W., Washington, D.C. 20549. You may obtain information on the operation of the Public Reference Room by calling the Commission at 1-800-SEC-0330.
 
The SEC also maintains a website that contains reports, proxy statements, information statements and other information concerning Internal Fixation Systems, Inc. located at http://www.sec.gov. This prospectus does not contain all the information required to be in the registration statement (including the exhibits), which we have filed with the SEC under the Securities Act and to which reference is made in this prospectus.
 
 
-34-

 
CALDERA PHARMACEUTICALS, INC.

CONSOLIDATED BALANCE SHEETS
 
   
September 30,
2011
(Unaudited)
   
 
December 31,
2010
 
ASSETS
           
             
Current assets:
           
Cash
  $ 916,653     $ 117,910  
Accounts receivable, net
    64,180       264,488  
Prepaid expenses
    875       3,010  
                 
Total current assets
    981,708       385,408  
                 
Non-current assets:
               
Intangible assets, net
    659,179       697,942  
Plant and equipment, net
    253,734       255,105  
                 
      912,913       953,047  
                 
TOTAL ASSETS
  $ 1,894,621     $ 1,338,455  
                 
                 
LIABILITIES AND STOCKHOLDERS’ EQUITY
               
                 
Current liabilities:
               
Accounts payable and accrued expenses
  $ 523,117     $ 416,495  
Preferred stock dividends payable
    49,071       -  
Loans payable
    29,687       116,084  
Loans from related parties
    -       77,600  
                 
Total current liabilities
    601,875       610,179  
                 
Non-current liabilities:
               
Loans payable
    248,447       270,952  
                 
      248,447       270,952  
                 
TOTAL LIABILITIES
    850,322       881,131  
                 
Stockholders’ equity:
               
Series A Convertible Preferred Stock, $0.001 par value, Authorized: 10,000,000 shares, 287,747 shares issued and outstanding as of September 30, 2011
        288         -  
Common stock, $0.001 par value, authorized 50,000,000  shares, 4,895,620 and 4,886,065 shares issued and outstanding as of December 31, 2010 and 2009, respectively
        4,896           4,886  
Additional paid in capital
    6,106,855       4,112,316  
Accumulated deficit
    (5,067,740 )     (3,659,878 )
                 
Total stockholder’s equity
    1,044,299       457,324  
                 
TOTAL LIABILITIES AND STOCKHOLDERS EQUITY
  $ 1,894,621     $ 1,338,455  
 
See notes to the financial statements on pages F-5 through F-24
 
 
CALDERA PHARMACEUTICALS, INC.
 
CONSOLIDATED STATEMENTS OF OPERATIONS
(UNAUDITED)
   
Nine months ended
September 30,
2011
   
Nine months ended September 30,
2010
 
             
Sales, net
  $ 416,164     $ 1,016,906  
                 
Cost of sales
    206,167       600,144  
Gross profit
    209,997       416,762  
                 
Operating expenses:
               
General and administrative expenses
    1,475,735       998,569  
Depreciation
    49,783       47,994  
Amortization
    38,763       38,763  
Total operating expenses
    1,564,281       1,085,326  
                 
Operating loss
    (1,354,284 )     (668,564 )
                 
Other income/(expense)
               
Other income
    7,988       -  
Interest income
    423       9  
Interest expense
    (12,918 )     (15,058 )
Total other income/(expense)
    (4,507 )     (15,049 )
Loss before income tax
    (1,358,791 )     (683,613 )
                 
Provision for income taxes
    -       -  
                 
Net loss
    (1,358,791 )     (683,613 )
                 
Deemed preferred stock dividends
    (49,071 )     -  
                 
Net loss applicable to common stock
  $ (1,407,862 )   $ (683,613 )
                 
Net loss per common stock:-
               
Basic and diluted
  $ (0.29 )   $ (0.15 )
                 
Weighted average number of common stock outstanding:-
               
Basic and diluted
    4,892,692       4,473,565  
 
See notes to the financial statements on pages F-5 through F-24
 
 
F-2

 
CALDERA PHARMACEUTICALS, INC.

CONSOLIDATED STATEMENT OF CHANGES IN STOCKHOLDER’S EQUITY
(UNAUDITED)
 
   
Preferred Stock
   
Common Stock
                   
   
Number
of
shares
   
 
 
Amount
   
Number
of
shares
   
 
 
Amount
   
 
Additional
paid in capital
   
 
Accumulated deficit
   
Total Stockholder’s Equity
 
                                           
Balance at December 31, 2010
    -     $ -       4,886,065     $ 4,886     $ 4,112,316     $ (3,659,878 )   $ 457,324  
                                                         
Unaudited:
                                                       
                                                         
Stock options exercised
    -       -       9,555       10       54,549       -       54,559  
                                                         
Issuance of Series A Convertible Preferred Stock and Common stock purchase Warrants
      287,747         288         -         -         1,639,862         -         1,640,150  
                                                         
Fair value of stock options issued to employees
    -       -       -       -       300,128       -       300,128  
                                                         
Net loss
    -       -       -       -       -       (1,358,791 )     (1,358,791 )
                                                         
Deemed preferred stock dividend
    -       -       -       -       -       (49,071 )     (49,071 )
                                                         
Balance at September 30, 2011 (Unaudited)
    287,747     $ 288       4,895,620     $ 4,896     $ 6,106,855     $ (5,067,740 )   $ 1,044,299  

See notes to the financial statements on pages F-5 through F-24
 
 
F-3

 
CALDERA PHARMACEUTICALS, INC.

CONSOLIDATED STATEMENTS OF CASH FLOWS
(UNAUDITED)
 
   
Nine months ended
September 30,
2011
   
Nine months ended
September 30,
2010
 
             
Cash flow from operating activities
           
Net loss
  $ (1,358,791 )   $ (683,613 )
Adjustments for non-cash items:
               
Depreciation
    49,783       47,994  
Amortization
    38,763       38,763  
Stock based compensation payments
    300,128       240,182  
                 
Changes in operating assets and liabilities:
               
Decrease in accounts receivable
    200,308       177,293  
Decrease in prepaid expenses
    2,135       45,692  
Increase in accounts payable and accrued expenses
    106,622       69,869  
                 
Net cash used in operating activities
    (661,052 )     (63,820 )
                 
Investing activities
               
Purchase of plant and equipment
    (48,412 )     (4,552 )
                 
Net cash used in investing activities
    (48,412 )     (4,552 )
                 
Financing activities
               
(Repayment)/Advance on line of credit
    (87,784 )     36,051  
Repayment of loan payable
    (21,118 )     (23,650 )
Repayment of stockholders loan
    (77,600 )     (7,339 )
Loan advanced by stockholder
    -       54,000  
Stock options exercised
    54,559       -  
Issuance of series A preferred stock and Warrants
    1,640,150       -  
                 
Net cash provided by financing activities
    1,508,207       59,062  
                 
Net increase/(decrease) in cash
    798,743       (9,310 )
                 
Cash at the beginning of the period
    117,910       45,936  
                 
Cash at the end of the period
  $ 916,653     $ 36,626  
                 
Supplemental disclosure of cash flow information
               
Cash paid for:
               
Interest
  $ 12,918     $ 15,058  
 
See notes to the financial statements on pages F-5 through F-24
 
 
F-4

 
CALDERA PHARMACEUTICALS, INC.

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS
 

1.  
GENERAL INFORMATION

Caldera Pharmaceuticals, Inc. (“the Company”) is a Delaware corporation with principal offices in Los Alamos, New Mexico and Chicago, Illinois. The Company was incorporated in November 2003.

The Company is a drug discovery and pharmaceutical instrument company which is based on a proprietary x-ray fluorescence technology, called XRpro®. Caldera offers what it believes to be uniquely broad and simple technologies to evaluate drug molecules, which increases the efficiency of analyzing and evaluating drug molecules for safety and efficacy at an early and less expensive stage.

The Company has generated the majority of its revenues to date through Government research contracts and Government grants utilizing its proprietary x-ray fluorescence technology.
 
2.  
ACCOUNTING POLICIES AND ESTIMATES

Basis of Presentation
The accompanying financial statements have been prepared in conformity with accounting principles generally accepted in the United States of America (“US GAAP”).

Consolidation
The consolidated financial statements include the financial statements of the Company and its subsidiaries in which it has a majority voting interest. Investments in affiliates are accounted for under the cost method of accounting, where appropriate. All significant inter-company accounts and transactions have been eliminated in the consolidated financial statements. The entities included in these consolidated financial statements are as follows:

Caldera Pharmaceuticals, Inc (Parent Company)
XRpro Corp.

Estimates
The preparation of these financial statements in accordance with US GAAP requires us to make estimates and judgments that affect the reported amounts of assets, liabilities, revenues and expenses, and related disclosure of contingent assets and liabilities. We continually evaluate our estimates, including those related to bad debts, inventories, recovery of long-lived assets. We base our estimates on historical experience and on various other assumptions that we believed to be reasonable under the circumstances, the results of which form the basis for making judgments about the carrying values of assets and liabilities that are not readily apparent from other sources. Any future changes to these estimates and assumptions could cause a material change to our reported amounts of revenues, expenses, assets and liabilities. Actual results may differ from these estimates under different assumptions or conditions. We believe the following critical accounting policies affect our more significant judgments and estimates used in the preparation of the financial statements. Significant estimates include the allowance for doubtful accounts, the allowance for obsolete inventory, the useful life of property and equipment and intangible assets, and assumptions used in assessing impairment of long-term assets.

All amounts referred to in the notes to the financial statements are in United States Dollars ($) unless stated otherwise.

 
CALDERA PHARMACEUTICALS, INC.

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS

 
2.  
ACCOUNTING POLICIES AND ESTIMATES (continued)

Contingencies
Certain conditions may exist as of the date the financial statements are issued, which may result in a loss to the Company but which will only be resolved when one or more future events occur or fail to occur. The Company’s management assesses such contingent liabilities, and such assessment inherently involves an exercise of judgment. In assessing loss contingencies related to legal proceedings that are pending against and by the Company or unasserted claims that may result in such proceedings, the Company’s management evaluates the perceived merits of any legal proceedings or unasserted claims as well as the perceived merits of the amount of relief sought or expected to be sought.
 
If the assessment of a contingency indicates that it is probable that a material loss has been incurred and the amount of the liability can be estimated, then the estimated liability would be accrued in the Company’s financial statements. If the assessment indicates that a potential material loss contingency is not probable but is reasonably possible, or is probable but cannot be estimated, then the nature of the contingent liability, together with an estimate of the range of possible loss if determinable and material would be disclosed. Loss contingencies considered to be remote by management are generally not disclosed unless they involve guarantees, in which case the guarantee would be disclosed.
 
Fair value of financial instruments
The Company adopted the guidance of Accounting Standards Codification (“ASC”) 820 for fair value measurements which clarifies the definition of fair value, prescribes methods for measuring fair value, and establishes a fair value hierarchy to classify the inputs used in measuring fair value as follows:

Level 1-Inputs are unadjusted quoted prices in active markets for identical assets or liabilities available at the measurement date.
 
Level 2-Inputs are unadjusted quoted prices for similar assets and liabilities in active markets, quoted prices for identical or similar assets and liabilities in markets that are not active, inputs other then quoted prices that are observable, and inputs derived from or corroborated by observable market data.
 
Level 3-Inputs are unobservable inputs which reflect the reporting entity’s own assumptions on what assumptions the market participants would use in pricing the asset or liability based on the best available information.

The carrying amounts reported in the balance sheets for cash, accounts receivable, loans payable, accounts payable and accrued expenses, and advances to suppliers approximate their fair market value based on the short-term maturity of these instruments. The Company did not identify any assets or liabilities that are required to be presented on the balance sheets at fair value in accordance with the accounting guidance.
 
ASC 825-10 “ Financial Instruments ”, allows entities to voluntarily choose to measure certain financial assets and liabilities at fair value (fair value option). The fair value option may be elected on an instrument-by-instrument basis and is irrevocable, unless a new election date occurs. If the fair value option is elected for an instrument, unrealized gains and losses for that instrument should be reported in earnings at each subsequent reporting date. The Company did not elect to apply the fair value option to any outstanding instruments.
 
 
CALDERA PHARMACEUTICALS, INC.

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS
 
 
2.  
ACCOUNTING POLICIES AND ESTIMATES (continued)

Recent accounting pronouncements

In October 2009, the FASB issued ASU No. 2009-14, “Certain Revenue Arrangements That Include Software Elements.” This ASU changes the accounting model for revenue arrangements that include both tangible products and software elements that are “essential to the functionality,” and scopes these products out of current software revenue guidance. The new guidance will include factors to help companies determine what software elements are considered “essential to the functionality.” The amendments will now subject software-enabled products to other revenue guidance and disclosure requirements, such as guidance surrounding revenue arrangements with multiple-deliverables. The amendments in this ASU are effective prospectively for revenue arrangements entered into or materially modified in the fiscal years beginning on or after June 15, 2010. Early application is permitted. The adoption of the new ASU did not have any important impact on the Company’s financial statements.

In January 2010, the FASB issued guidance to amend the disclosure requirements related to fair value measurements. The guidance requires the disclosure of roll forward activities on purchases, sales, issuance, and settlements of the assets and liabilities measured using significant unobservable inputs (Level 3 fair value measurements). The guidance will become effective for us with the reporting period beginning July 1, 2011. Other than requiring additional disclosures, the adoption of this new guidance will not have a material impact on our financial statements.

In January 2010, the FASB issued Accounting Standards Update ("ASU") No. 2010-06 for Fair Value Measurements and Disclosures (Topic 820):  Improving Disclosures about Fair Value Measurements . This Update requires new disclosures for transfers in and out of Level 1 and 2 and activity in Level 3. This Update also clarifies existing disclosures for level of disaggregation and requires additional disclosures about inputs and valuation techniques. The new disclosures are effective for interim and annual periods beginning after December 15, 2009, except for the Level 3 disclosures, which are effective for fiscal years beginning after December 15, 2010 and for interim periods within those years. Other than requiring additional disclosures, adoption of this new guidance did not have a material impact on the Company's financial statements and is not expected to have a significant impact on the reporting of the Company's financial condition or results of operations.

In February 2010, the FASB (Financial Accounting Standards Board) issued Accounting Standards Update 2010-09 (ASU 2010-09), Subsequent Events (Topic 855): Amendments to Certain Recognition and Disclosure Requirements.  This amendment addresses both the interaction of the requirements of this Topic with the SEC’s reporting requirements and the intended breadth of the reissuance disclosure provision related to subsequent events (paragraph 855-10-50-4).  All of the amendments in this Update are effective upon issuance of the final Update, except for the use of the issued date for conduit debt obligors. That amendment is effective for interim or annual periods ending after June 15, 2010.  The adoption of the new ASU did not have any important impact on the Company’s financial statements.

In March 2010, the FASB ratified the milestone method of revenue recognition. Under this standard, an entity can recognize contingent consideration earned from the achievement of a substantive milestone in its entirety in the period in which the milestone is achieved. A milestone is defined as an event (i) that can only be achieved based in whole or in part on either the entity's performance or on the occurrence of a specific outcome resulting from the entity's performance (ii) for which there is substantive uncertainty at the date the arrangement is entered into that the event will be achieved and (iii) that would result in additional payments being due to the entity. This guidance is effective for years beginning after June 15, 2010. This guidance did not have any important impact on the Company’s financial statements.

In   March 2010, the FASB issued ASU 2010-11, Derivatives and Hedging (Topic 815): Scope Exception Related to Embedded Credit Derivatives.  The amendments in this Update are effective for each reporting entity at the beginning of its first fiscal quarter beginning after June 15, 2010.  Early adoption is permitted at the beginning of each entity’s first fiscal quarter beginning after issuance of this Update.  The Company does not expect the provisions of ASU 2010-11 to have a material effect on the financial position, results of operations or cash flows of the Company.
 
 
CALDERA PHARMACEUTICALS, INC.

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS

 
2.  
ACCOUNTING POLICIES AND ESTIMATES (continued)

Recent accounting pronouncements (continued)

In   April 2010, the FASB issued ASU 2010-13, Compensation-Stock Compensation (Topic 718): Effect of Denominating the Exercise Price of a Share-Based Payment Award in the Currency of the Market in Which the Underlying Equity Security Trades – a consensus of the FASB Emerging Issues Task Force.  The amendments in this Update are effective for fiscal years, and interim periods within those fiscal years, beginning on or after December 15, 2010.  Earlier application is permitted.  The Company does not expect the provisions of ASU 2010-13 to have a material effect on the financial position, results of operations or cash flows of the Company.

In May 2010, the FASB issued ASU 2010-19, Foreign Currency (Topic 830): Foreign Currency Issues: Multiple Foreign Currency Exchange Rates.  The amendments in this Update are effective as of the announcement date of March 18, 2010. The Company does not expect the provisions of ASU 2010-19 to have a material effect on the financial position, results of operations or cash flows of the Company.
 
In May 2011, the FASB issued guidance to amend the accounting and disclosure requirements on fair value measurements. The new guidance limits the highest-and-best-use measure to nonfinancial assets, permits certain financial assets and liabilities with offsetting positions in market or counterparty credit risks to be measured at a net basis, and provides guidance on the applicability of premiums and discounts. Additionally, the new guidance expands the disclosures on Level 3 inputs by requiring quantitative disclosure of the unobservable inputs and assumptions, as well as description of the valuation processes and the sensitivity of the fair value to changes in unobservable inputs. The new guidance will be effective for us beginning January 1, 2012. Other than requiring additional disclosures, we do not anticipate material impacts on our financial statements upon adoption.
 
In June 2011, the FASB issued guidance on presentation of comprehensive income. The new guidance eliminates the current option to report other comprehensive income and its components in the statement of changes in equity. Instead, an entity will be required to present either a continuous statement of net income and other comprehensive income or in two separate but consecutive statements. The new guidance will be effective for us beginning July 1, 2012 and will have presentation changes only.
 
  Other accounting standards that have been issued or proposed by FASB that do not require adoption until a future date are not expected to have a material impact on the consolidated financial statements upon adoption.
 
Reporting by segment
No segmental information is presented as the Company only has one significant reporting segment which is Government Revenues.

Intangible assets

c)  
License Agreements
License agreements acquired by the Company are reported at acquisition value less accumulated amortization and impairments.
 
  b) Amortization
Amortization is reported in the income statement straight-line over the estimated useful life of the intangible assets, unless the useful life is indefinite. Amortizable intangible assets are amortized from the date that they are available for use. The estimated useful life of the license agreement is twenty years which is the term of the patent supporting the underlying license agreements

Assessment of an intangible asset’s residual value and useful life is performed annually.
 
 
CALDERA PHARMACEUTICALS, INC.

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS
 
 
2.  
ACCOUNTING POLICIES AND ESTIMATES (continued)

Plant and equipment
Plant and equipment is stated at cost less accumulated depreciation.  Depreciation is computed using straight-line method over the estimated useful lives of the assets. The estimated useful lives of the assets are as follows:

Leasehold improvements                                                                    5 Years
Laboratory equipment                                                                         7 Years
Furniture and fixtures                                                                          10 Years
Computer equipment                                                                           3 Years

The cost of repairs and maintenance is expensed as incurred; major replacements and improvements are capitalized. When assets are retired or disposed of, the cost and accumulated depreciation are removed from the accounts, and any resulting gains or losses are included in income in the year of disposition.

We examine the possibility of decreases in the value of fixed assets when events or changes in circumstances reflect the fact that their recorded value may not be recoverable. We recognize an impairment loss when the sum of expected undiscounted future cash flows is less than the carrying amount of the asset. The amount of impairment is measured as the difference between the asset’s estimated fair value and its book value.

Concentrations of credit risk
The Company’s operations are carried out in the USA. Accordingly, the Company’s business, financial condition and results of operations may be influenced by the political, economic and legal environment in the USA and by the general state of the economy. The Company’s results may be adversely affected by changes in governmental policies with respect to laws and regulations, anti-inflationary measures, and rates and methods of taxation, among other things.

Concentration of major customers
The Company currently derives substantially all of its revenues from Government research contracts.

During the nine months ended September 30, 2011, the Company recorded revenues from six different research projects from Government agencies totaling 96% of its revenues. During the nine months ended September 30, 2009, the Company recorded revenues from nine different research projects from Government agencies totaling 100% of its revenues.

Accounts receivable and other receivables
We have a policy of reserving for uncollectible accounts based on our best estimate of the amount of probable credit losses in our existing accounts receivable.  We periodically review our accounts receivable and other receivables to determine whether an allowance is necessary based on an analysis of past due accounts and other factors that may indicate that the realization of an account may be in doubt.  Account balances deemed to be uncollectible are charged to the allowance after all means of collection have been exhausted and the potential for recovery is considered remote.

The amount charged to bad debt provision for the nine months ended September 30, 2011 and 2010 was $nil.

As a basis for accurately estimating the likelihood of collection has been established, we consider a number of factors when determining reserves for uncollectable accounts.   We believe that we use a reasonably reliable methodology to estimate the collectability of our accounts receivable. We review our allowances for doubtful accounts on a regular basis. We also consider whether the historical economic conditions are comparable to current economic conditions. If the financial condition of our customers or other parties that we have business relations with were to deteriorate, resulting in an impairment of their ability to make payments, additional allowances may be required.
 
 
CALDERA PHARMACEUTICALS, INC.

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS

 
2.  
ACCOUNTING POLICIES AND ESTIMATES (continued)

Cash and cash equivalents
For purposes of the statements of cash flows, the Company considers all highly liquid instruments purchased with a maturity of three months or less and money market accounts to be cash equivalents. The Company maintains cash and cash equivalents with two financial institutions in the USA.  

Revenue recognition
Revenue sources consist of government grants, government contracts and commercial development contracts.
 
Revenues from government grants and contracts are for research and development purposes and are recognized in accordance with the terms of the award and the government agency. Grant revenue is recognized in one of two different ways depending on the grant. Cost reimbursement grants require us to submit proof of costs incurred that are invoiced by us to the government agency, which then pays the invoice. In this case, grant revenue is recognized during the period that the costs were incurred according to the terms of the government grant. Fixed cost grants require no proof of costs at the time of invoicing, but proof is required for audit purposes and grant revenue is recognized during the period that the costs were incurred according to the terms of the government grant. The grant revenue under these fixed costs grants is recognized using a percentage-of-completion method, which uses assumptions and estimates. These assumptions and estimates are developed in coordination with the principal investigator performing the work under the government fixed-cost grants to determine key milestones, expenses incurred, and deliverables to perform a percentage-of-completion analysis to ensure that revenue is appropriately recognized. Critical estimates involved in this process include total costs incurred and anticipated to be incurred during the remaining life of the grant.

Government contract revenue is recognized as allowable research and development expenses are incurred during the period and according to the terms of the government contract.

Commercial revenue is recognized when the service or development is delivered or upon complying with the relevant terms of the commercial agreement.

Sales and Marketing
Sales and marketing expenses are minimal at present. These costs, if any, are expensed as incurred and included in Selling, general and administrative expenses. The Company expects to incur substantial sales and marketing expenses in future periods to promote its x-ray florescence equipment to drug discovery enterprises.

Research and Development
The remuneration of the Company’s research and development staff, materials used in internal research and development activities, and payments made to third parties in connection with collaborative research and development arrangements, are all expensed as incurred.  Where the company makes a payment to a third party to acquire the right to use a product formula which has received regulatory approval, that payment is accounted for as the acquisition of a license or patent and is capitalized as an intangible asset and amortized over the shorter of the remaining license period or patent life.

The amount expensed for research costs during the nine months ended September 30, 2011 and 2010 is immaterial.

Patent Costs
Legal costs in connection with approved patents and patent applications are expensed as incurred and classified as selling, general and administrative expense in our consolidated statement of operations.
 
 
CALDERA PHARMACEUTICALS, INC.

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS

 
2.  
ACCOUNTING POLICIES AND ESTIMATES (continued)

Share-Based Compensation
Share-based compensation cost is measured at the grant date, based on the estimated fair value of the award and is recognized as expense over the employee's requisite service period on a straight-line basis. Share-based compensation expense recognized in the consolidated statements of operations for the years ended December 31, 2010 and 2009 is based on awards ultimately expected to vest and has been reduced for estimated forfeitures. This estimate will be revised in subsequent periods if actual forfeitures differ from those estimates. We have no awards with market or performance conditions.

Income Taxes
The Company utilizes SFAS No. 109, Accounting for Income Taxes, included in the Codification as ASC 740, Income Taxes, which requires the recognition of deferred tax assets and liabilities for the expected future tax consequences of events that have been included in the financial statements or tax returns. Under this method, deferred income taxes are recognized for the tax consequences in future years of differences between the tax bases of assets and liabilities and their financial reporting amounts at each period end based on enacted tax laws and statutory tax rates applicable to the periods in which the differences are expected to affect taxable income. Valuation allowances are established, when necessary, to reduce deferred tax assets to the amount expected to be realized.

Net Loss per Share
Basic net loss per share is computed on the basis of the weighted average number of common stock outstanding during the period.

Diluted net income per share is computed on the basis of the weighted average number of common stock and common stock equivalents outstanding. Dilutive securities having an anti-dilutive effect on diluted net income per share are excluded from the calculation.

Dilution is computed by applying the treasury stock method for options and warrants. Under this method, options and warrants are assumed to be exercised at the beginning of the period (or at the time of issuance, if later), and as if funds obtained thereby were used to purchase common stock at the average market price during the period.

Dilution is computed by applying the if-converted method for convertible preferred stocks. Under this method, convertible preferred stock is assumed to be converted at the beginning of the period (or at the time of issuance, if later), and preferred dividends (if any) will be added back to determine income applicable to common stock. The shares issuable upon conversion will be added to weighted average number of common stock outstanding. Conversion will be assumed only if it reduces earnings per share (or increases loss per share).

Comprehensive income
Comprehensive income is defined as the change in equity of a company during a period from transactions and other events and circumstances excluding transactions resulting from investments from owners and distributions to owners. For the Company, comprehensive income for the periods presented includes net income.
 
 
CALDERA PHARMACEUTICALS, INC.

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS
 
2.  
ACCOUNTING POLICIES AND ESTIMATES (continued)

Related parties
Parties are considered to be related to the Company if the parties that, directly or indirectly, through one or more intermediaries, control, are controlled by, or are under common control with the Company. Related parties also include principal owners of the Company, its management, members of the immediate families of principal owners of the Company and its management and other parties with which the Company may deal if one party controls or can significantly influence the management or operating policies of the other to an extent that one of the transacting parties might be prevented from fully pursuing its own separate interests. The Company shall disclose all related party transactions. All transactions shall be recorded at fair value of the goods or services exchanged. Property purchased from a related party is recorded at the cost to the related party and any payment to or on behalf of the related party in excess of the cost is reflected as a distribution to related party.
 
3.  
GOING CONCERN

As shown in the accompanying financial statements, the Company incurred a net loss of $1,358,791 and $683,613 during the nine months ended September 30, 2011 and 2010, respectively. As of September 30, 2011, the Company had an accumulated deficit of $5,067,740. The Company had a working capital of $379,833 at September 30, 2011. These operating losses create an uncertainty about the Company’s ability to continue as a going concern. Although no assurances can be given, management of the Company believes that potential additional issuances of equity or other potential financing will provide the necessary funding for the Company to continue as a going concern. The financial statements do not include any adjustments that might be necessary if the Company is unable to continue as a going concern. The Company is economically dependent upon future capital contributions or financing to fund ongoing operations.

4.  
INTANGIBLE ASSETS

Licenses
In terms of an Exclusive Patent License agreement covering national and international patents entered into with the Los Alamos National Security LLC. Dated September 8, 2005, the Company has the exclusive right to the use of certain patents covering the following:

·  
Method for Detecting Binding Events Using Micro X-Ray Fluorescence Spectrometry;
·  
Flow Method and Apparatus for Screening Chemicals Using Micro X-Ray Fluorescence;
·  
Method and Apparatus for Detecting Chemical Binding;
·  
Drug Development and Manufacturing.

The agreement provides for a term as long as the last surviving patent which is generally a twenty year period from the date of first application.

In terms of the agreement, The Company issued shares to the Licensor equal to 3% of the issued equity of the Company. The agreement contains anti-dilutive clauses which will ensure that the Licensor maintains at least a 3% shareholding in the Company until the Company achieves equity financing of at least $20 million.  As of December 31, 2010, the Company has not yet raised the requisite amount of financing.  The Licensor continued to hold, at a minimum, 3% of the Company’s common stock.
 
 
CALDERA PHARMACEUTICALS, INC.

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS

 
4.  
INTANGIBLE ASSETS (continued)

The agreement further provides for an annual royalty to be paid to the Licensee at a rate of 2% per annum on net sales, excluding any sales to Government agencies. The agreement provided for a minimum royalty payment of $25,000 per annum for the financial years ended December 31, 2006 to December 31, 2010. Thereafter the minimum royalty payment increases to $50,000 per annum up until December 31, 2022.

   
September 30,
2011
   
December 31,
2010
 
             
Licenses, at cost
  $ 972,000     $ 972,000  
Less: Accumulated amortization
    (312,821 )     (274,058 )
                 
    $ 659,179     $ 697,942  

The aggregate amortization expense charged to operations was $38,763 and $38,763 for the nine months ended September 30, 2011 and 2010, respectively. The amortization policies followed by the company are described in Note (2).

Amortization expense for the future years is summarized as follows:

   
Amount
 
       
2011
  $ 12,921  
2012
    51,684  
2013
    51,684  
2014
    51,684  
2015
    51,684  
2016 and thereafter
    439,522  
Total
  $ 659,179  

Patents

The Company has various patents pending or registered in its name. These patents have been internally generated and all costs associated with the research and development of these patents has been expensed.

The patents assigned to Caldera are as follows:

·  
Well Plate – apparatus for preparing samples for measurement by x-ray fluorescence spectrometry. Patent filed August 15, 2008
·  
Method and Apparatus for measuring Protein Post Translational Modification. Patent filed September 26, 2008.
·  
Method and Apparatus for Measuring Analyte Transport across barriers. Patent filed July 1, 2009.
 
 
F-13

 
CALDERA PHARMACEUTICALS, INC.

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS
 
 
5.  
PLANT AND EQUIPMENT

Plant and equipment consists of the following at September 30, 2011 and December 31, 2010.

   
September 30,
2011
   
December 31,
2010
 
             
Leasehold improvements
  $ 6,393     $ 6,393  
Furniture and fittings
    7,114       7,114  
Laboratory equipment
    455,742       413,269  
Computer equipment
    28,378       22,439  
                 
Total
    497,627       449,215  
Accumulated depreciation
    (243,893 )     (194,110 )
    $ 253,734     $ 255,105  

The aggregate depreciation charge to operations was $49,783 and $47,994 for the nine months ended September 30, 2011 and 2010 respectively. The depreciation policies followed by the company are described in Note (2).

6.  
ACCOUNTS PAYABLE AND ACCRUED EXPENSES

   
September 30,
2011
   
December 31,
2010
 
             
Accounts payable
  $ 363,536     $ 290,891  
Credit card liabilities
    17,025       2,342  
Vacation and Sick Pay accrual
    123,255       85,228  
Payroll liabilities
    12,701       28,489  
Other
    6,600       9,545  
                 
    $ 523,117     $ 416,495  
 
 
CALDERA PHARMACEUTICALS, INC.

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS

 
7.  
INCOME TAXES

Due to our historical net loss position, and valuation allowance against deferred tax assets, there is no provision or benefit for income taxes recorded for the nine months ended September 30, 2011 and 2010.

The income tax provision/ (benefit) is different from that which would be obtained by applying the statutory Federal income tax rate of 35% to income before income tax expense. The items causing this difference for the nine months ended September 30, 2011 and 2010 are as follows:

   
September 30,
2011
   
September 30,
2010
 
             
Income tax benefit at federal statutory rate
  $ (475,577 )   $ (239,265 )
State taxes, net of federal benefit
    (67,949 )     (34,181 )
Other
    13,775       -  
Stock based compensation
    120,051       96,073  
      (409,700 )     (177,373 )
Valuation allowances
    409,700       177,373  
    $ -     $ -  

Deferred income taxes reflect the net tax effect of temporary differences between the carrying amount of assets and liabilities for financial reporting purposes and the amounts used for income tax purposes. Significant components of deferred tax assets and liabilities at September 30, 2011 and December 31, 2010 are as follows:
 
   
September 30,
2011
   
December 31,
2010
 
Deferred tax assets
           
Accrual to cash adjustments
  $ 168,700     $ 60,000  
Plant and equipment
    10,500       10,500  
Net operating loss
    1,001,000       697,000  
      1,180,200       767,500  
Valuation allowances
    (1,105,200 )     (695,500 )
      75,000       72,000  
Amortization accrual to cash basis
    (75,000 )     (72,000 )
Total deferred tax assets, net of valuation allowances
  $ -     $ -  

We have established a valuation allowance against our gross deferred tax assets sufficient to bring our net deferred tax assets to zero due to the uncertainty surrounding the realization of such assets. Management has determined it is more likely than not that the deferred tax assets are not realizable due to our historical loss position. The valuation allowance at September 30, 2011 and December 31, 2010 was $1,105,500 and $695,500, respectively. The valuation allowance increased by $409,700 during the nine months ended September 30, 2011

At September 30, 2011, we had tax loss carry forwards of approximately $2,503,000. These net operating loss carry forwards begin to expire in 2023, if unused.
 
 
CALDERA PHARMACEUTICALS, INC.

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS

 
7.  
INCOME TAXES (continued)

Pursuant to the Internal Revenue Code of 1986, as amended, ("IRC") §382, our ability to use net operating loss  carry forwards to offset future taxable income is limited if we experience a cumulative change in ownership of more than 50% within a three-year period.

The Company’s 2009 and 2010 Federal income tax returns have been examined by the Internal Revenue Service (“IRS”) and the adjustments proposed by the IRS were agreed to by the Company. The Company’s tax provision reflects the IRS’ audit adjustments and the Company believes that there are no remaining uncertain tax positions requiring recognition.

8.  
LOANS PAYABLE

   
September 30,
2011
   
December 31,
2010
 
Short term  portion
           
Los Alamos County Loan
  $ 29,687     $ 28,300  
Los Alamos National Bank
    -       87,784  
                 
      29,687       116,084  
Long term portion
               
                 
Los Alamos County Loan
    248,447       270,952  
                 
    $ 278,134     $ 387,036  

Los Alamos County Loan

The Company entered into a Project Participation Agreement (as Amended) and a Loan Agreement with the Incorporated County of Los Alamos as of September 21, 2006. The Agreement provided for funding up to a maximum of $2,200,000 for the construction of a building and purchase of equipment. The maximum amount of equipment to be funded out of the total available loan of $2,200,000 was $625,000. The term of the loan is 13 years. The loan agreement provided for no repayments for 36 months with 120 equal monthly repayments commencing on September 21, 2009. The interest rate on the loan is 5% per annum. The assets funded in terms of the Project Participation Agreement and the Loan Agreement is to be used as security for the balance of the loan outstanding.

The Company made use of the loan to purchase assets amounting to $302,009 during the 2007 financial year. Repayments of the loan commenced on September 21, 2009 at an interest rate of 5% per annum with equal monthly repayments of $3,546.87.

 
CALDERA PHARMACEUTICALS, INC.

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS

 
8.  
LOANS PAYABLE (continued)

Los Alamos National Bank
The Company entered into a one year revolving draw loan with Los Alamos National Bank as of April 23, 2010 with a principal available of $300,000. The Company drew $86,800 on the loan on April 23, 2010, utilizing $50,000 to repay the balance outstanding on loan 1 above. The loan bears interest at a coupon of the Wall Street Journal Prime rate plus 1% with a floor of 6% per annum. This loan is secured by inventory, accounts receivable and other rights to payments, instruments, documents and other Chattel paper, general intangibles and fixed assets. Interest is payable quarterly. The loan was repaid in full on May 23, 2011.

The Los Alamos National Bank has provided a further facility to Caldera Pharmaceuticals of $750,000 as of May 23, 2011 for a period of one year. The loan bears interest at a coupon of the Wall Street Journal Prime rate plus 1% with a floor of 4.75% per annum. This loan is secured by inventory, Accounts and other rights to payments, instruments, documents and other Chattel paper, general intangibles and fixed assets. Interest is payable quarterly. No funds have been drawn under this facility during the current year.

9.  
COMMON STOCK

Common stock consists of 50,000,000 authorized shares of $0.001 each.
 
The Company has raised funding through debt and equity financings. The following provides a description of the Company's equity financings in connection with such equity financings.
 
In terms of  settlement agreement entered into between three existing shareholders of the Company and a further settlement agreement entered into between the Company and these shareholders, a further 90,000 shares were issued to two existing shareholders in exchange for their judgment and settlement agreement obtained against the third shareholder. The agreement entitles the Company to redeem 177,500 shares of common stock of the third shareholder and a forgiveness of a debt owing to the third shareholder of $34,040. The cancellation of the 177,500 shares will only take place in 2011 once a Stay and Collection Judgment obtained against Caldera Pharmaceuticals by our previous legal counsel has been dismissed. This dismissal was obtained in November 2011.
 
A further 324,500 shares of common stock were issued for $178,475 for consulting services rendered by a third party. The consulting agreement includes business development and capital raising to fund the future expansion of the Company.

During the nine months ended September 30, 2011, certain employees of the Company exercised options over 9,555 shares of common stock at an exercise price of $5.71 per share, thereby receiving 9,555 shares of common stock.
 
 
CALDERA PHARMACEUTICALS, INC.

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS

 
10.  
SERIES A 8% CONVERTIBLE PREFERRED STOCK AND COMMON STOCK PURCHASE WARRANTS

In terms of a private placement memorandum dated June 24, 2011, 287,746 units of series A convertible preferred stock (“Preferred Stock”) and common stock purchase warrants were issued to Series A preferred stockholders at a par value of $0.001 per share for a total consideration of $1,640,150. A further 40,000 warrants were issued to advisors to acquire shares of common stock at a price of $5.71 per share in conjunction with the private placement. The Preferred Stock will convert to common stock of the Company at a price of $5.70 per Common Stock subject to adjustment for stock splits, stock dividends and any further recapitalizations. The Preferred Stock is subject to voluntary conversion at the option of the stockholder at any time and is mandatory convertible at the option of the Company provided the Company’s common stock is trading on a recognized stock exchange or Over the Counter Bulletin Board and the volume weighted average price of the Company’s common stock is at least $10 per share, subject to stock splits, stock dividends and recapitalizations.

The Preferred Stock Holders will receive warrants to purchase shares of the Company’s common stock equal to 100% of the number of shares that they would receive upon conversion of the Preferred stock into common stock at an exercise price of $5.70 per share. The Warrants will expire five years after date of issuance. The Warrants are not transferable separately from the Preferred Stock without the consent of the Company and an opinion of Counsel satisfactory to the Company.

Should the Company receive net proceeds of at least $3 million from litigation proceedings against the managers of Los Alamos National Laboratory; the Preferred Stock holder will have the option to redeem the Preferred Stock equal to 130% of the price per share of $5.70. The Company also has the option to redeem the Preferred Stock at a price equal to 130% of the price per share of $5.70 at any time after giving the investors notice and allowing them to exercise their conversion rights into common stock 30 days after notice has been received.

The Preferred stock carries an 8% cumulative, non-compounded dividend payable on January 31, each year. In cash or in kind at the option of the Preferred Stock holder. For any other dividends or distributions, the Preferred Stock is treated on an as converted basis.
 
 
 
F-18

 
CALDERA PHARMACEUTICALS, INC.

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS
 
 
11.  
WARRANTS

During the current year, warrants were issued to investors in conjunction with the Series A Preferred Stock. In addition, warrants were also issued to the placement agent in the Preferred Stock financing. See details of the equity financings above.

At September 30, 2011, outstanding warrants to purchase shares of common stock are as follows:

Warrants
   
Exercise Price
 
Expiration Date
           
  22,272     $ 5.70  
March 2016
  108,982     $ 5.70  
April 2016
  86,404     $ 5.70  
May 2016
  35,000     $ 5.70  
June 2016
  40,000     $ 5.70  
July 2016
  35,088     $ 5.70  
September 2016
               
  327,746            

12.  
STOCK BASED COMPENSATION
 
In October 2005, the Company's Board of Directors adopted the Caldera Pharmaceuticals, Inc. 2005 Stock Option Plan (the "Plan"), which permits awards of incentive and nonqualified stock options and other forms of incentive compensation to employees and non-employees such as directors and consultants. The Board has 3,000,000 shares of common stock for issuance upon exercise of grants made under the Plan. Options granted under the Plan vest either immediately or over a period of up to two years, and expire 4 years to 10 years from the grant date. At September 30, 2011, 466,555 shares were available for future grant under the Incentive Plan.
 
Stock-based compensation expense totaled $300,128 and $240,182 for the nine months ended September 30, 2011 and 2010 respectively. The Company expenses the value of stock options as earned. The fair value of the options granted is determined using the Black-Scholes option-pricing model. The following weighted average assumptions were used:
 
   
Nine months ended
September 30,
2011
   
Nine months ended
September 30,
2010
 
             
Risk-free interest rate
 
0.01% to 0.15%
      0.15% - 0.14%  
Expected life of the options    5 Years     5 Years  
Expected volatility of the underlying stock
    128%       128%  
Expected dividend rate
    0%       0%  
 
 
CALDERA PHARMACEUTICALS, INC.

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS

12.  
STOCK BASED COMPENSATION (continued)
 
As noted above, the fair value of stock options is determined by using the Black-Scholes option pricing model. For all options granted since October 1, 2005 the Company has generally used option terms of between 4 to 10 years, with 5 years representing the estimated life of options granted. The volatility of the common stock is estimated using historical data of companies similar in size and in the same industry as Caldera Pharmaceuticals.  The risk-free interest rate used in the Black-Scholes option pricing model is determined by reference to historical U.S. Treasury constant maturity rates with short term maturities of no more than three months. An expected dividend yield of zero is used in the option valuation model, because the Company does not expect to pay any cash dividends in the foreseeable future. At December 31, 2010, the Company does not anticipate any awards will be forfeited in the calculation of compensation expense due to the limited number of employees that receive stock option grants.
 
During the nine months ended September 30, 2011, 9,555 options were exercised at an exercise price of $5.71 per share of common stock at a value of $54,559.
 
During the nine months ended September 30, 2011 we cancelled options over 220,000 shares of common stock. These options were issued during the year with expiry dates of three months after termination of employment by the company. No options were cancelled for the nine months ended September 30, 2010 The shares underlying such options were returned to and are available for re-issuance under the 2005 Plan pursuant to the terms described above.
 
During the nine months ended  September 30, 2011 and the year ended December 31, 2010, all awards granted under the Plan were incentive stock options. A summary of all of our option activity as of September 30, 2011 and December 31, 2010 and of changes in options outstanding under the plans during the nine months ended September 30, 2011 are as follows:
 
   
 
Shares
   
Exercise price per share
   
Weighted average exercise price
 
                   
Outstanding January 1, 2010
    277,688     $ 2.00 - $5.71     $ 4.77  
Granted
    65,000     $ 5.71     $ 5.71  
Forfeited/Cancelled
    (57,188 )   $ 2.00 - $5.71     $ 4.09  
Exercised
    -       -       -  
                         
Outstanding December 31, 2010
    285,500     $ 2.00 - $5.71     $ 5.13  
Granted
    477,500     $ 1.10 - $5.71       1.77  
Forfeited/Cancelled
    (220,000 )   $ 1.10       1.10  
Exercised
    (9,555 )   $ 5.71     $ 5.71  
                         
Outstanding September 30, 2011
    533,445     $ 1.10 - $5.71     $ 3.50  
 
 
CALDERA PHARMACEUTICALS, INC.

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS
 
 
12.  
STOCK BASED COMPENSATION (continued)

The following tables summarize information about stock options outstanding at September 30, 2011:
 
     
Options Outstanding
   
Options Exercisable
 
 
 
 
 
Exercise Price
   
 
 
 
Number of shares
   
Weighted average remaining contractual years
   
 
 
Weighted Average Exercise Price
   
 
 
 
Number of Shares
   
 
 
Weighted Average exercise Price
 
                                 
$ 1.10       220,000       9.42     $ 1.10       220,000     $ 1.10  
$ 2.00       45,000       4.11     $ 2.00       45,000     $ 2.00  
$ 5.71       268,445       7.24     $ 5.71       214,445     $ 5.71  
                                             
          533,445       7.88     $ 3.50       479,445     $ 3.25  

The weighted-average grant-date fair values of options granted during the nine months ended September 2011 and the year ended December 31, 2010 were $0.43 and $4.84 respectively. As of September 30, 2011 there were unvested options to purchase 54,000 shares of common stock. Total expected unrecognized compensation cost related to such unvested options is $85,884 which is expected to be recognized over a weighted–average period of 8 months.

13.  
NET LOSS PER COMMON SHARE
 
Basic loss per share is based on the weighted-average number of common shares outstanding during each period. Diluted loss per share is based on basic shares as determined above plus the incremental shares that would be issued upon the assumed exercise of in-the-money stock options and warrants using the treasury stock method. The computation of diluted net loss per share does not assume the issuance of common shares that have an anti-dilutive effect on net loss per share. For the nine months ended September 30, 2011 and 2010, all stock options, Series A Preferred Stock and Warrants were excluded from the computation of diluted net loss per share. Dilutive shares which could exist pursuant to the exercise of outstanding stock instruments and which were not included in the calculation because their affect would have been anti-dilutive are as follows:
 
   
Nine months ended
September 30,
2011
(Shares)
   
Nine months ended
September 30,
2010
(Shares)
 
             
Series A Convertible Preferred stock
    287,746       -  
Warrants
    327,746       -  
Options to purchase shares of common stock
    533,445       285,500  
                 
      1,148,937       285,500  
 
 
CALDERA PHARMACEUTICALS, INC.

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS
 
 
14.  
RELATED PARTY TRANSACTIONS

The majority of the share in the Company is owned by Benjamin Warner, the Chief Executive Officer. As at September 30, 2011 and December 31, 2010, Benjamin Warner owned 65.6% and 65.7% respectively.

Loans from related parties

   
September 30,
2011
   
December 31,
2010
 
             
Benjamin P Warner
    -       77,600  
                 
    $ -     $ 77,600  

The loan from Benjamin Warner is interest free and has no fixed repayment terms.

15.  
OPERATING LEASES

The Company extended its existing office lease effective November 1, 2010. The monthly rent amounts to $4,784 per month and the lease terminates in October 2013.

The Company entered into an office sub-lease agreement with Greg Rzepczynski & Associates, LTD effective September1, 2011. The monthly rent amounts to $4,000 per month and the lease expires in September 2012.

Future annual minimum payments required under operating lease obligations at September 30, 2011, are as follows:

   
Amount
 
       
2011
  $ 26,639  
2012
    95,426  
2013
    50,753  
Total
  $ 172,818  
 
 
CALDERA PHARMACEUTICALS, INC.

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS
 
 
16.  
LITIGATION

Los Alamos National Security Suit

In October 2010, the Company filed suit against Los Alamos National Security LLC (“LANS”) and seven other co-defendants in the United States District Court For the Northern District of Illinois Eastern Division alleging the following: (i) Breach of Contract; (ii) Fraud; (iii) Intentional Interference with Contractual Relations; (iii) Legal Malpractice; and other related claims in connection with an exclusive Patent Licensing Agreement (the “Agreement”) originally entered into between the Company and the Regents of the University of California (the “Regents”) in September 2005. In April 2006, the Regents assigned the Agreement to LANS. The Company believes the defendants made false representations that were critical to its decision to enter into the Agreement including: (i) the Regents was the lawful owner of the patent rights covered by the Agreement; and (ii) the Regents would prosecute and maintain these patent rights and notify the Company if it decided to abandon them. The Company also believes that LANS and other co-defendants improperly competed with the Company. In addition, the Company believes that two of the co-defendants, both in-house patent attorneys for LANS, breached their professional duties. The Company believes it has suffered substantial damages from the defendants’ actions. The Company also filed suit against the Regents and LANS in California Superior Court in San Francisco in December 2007. This suit was dismissed for reason of lack of subject matter jurisdiction by the Court. We believe that this dismissal was made incorrectly, and are appealing this ruling. The defendants filed countersuits, which were also dismissed. Should LANS or other defendants file or re-file countersuits, the Company intends to vigorously defend itself.

In September 2011, the Company filed suit against the Regents of the University of California and Los Alamos National Security LLC ("LANS") in the Circuit Court of Cook County. LANS removed the case to federal court, Case # ll-CV-07259. The Company's complaint alleges the following: (i) Breach of Contract; (ii) Breach of the Implied Covenant of Good Faith; (iii) Fraud; and (iv) Fraudulent Inducement, in connection with an exclusive Patent Licensing Agreement (the "Agreement") originally entered into between the Company and the Regents of the University of California (the "Regents") in September 2005 and assigned to LANS in April 2006. The Company believes the defendants breached a License Agreement, and made false representations that were critical to the Company's decision to enter into the Agreement. The Company believes it has suffered substantial damages from the Defendants' actions.

Seddie Bastanipour and Joel Bellows Suit

In October 2008, Seddie Bastanipour and Joel Bellows filed suit against the Company, our Chief Executive Officer, Dr. Benjamin Warner, and a former consultant to the Company, Sigmund Eisenchenk. Joel Bellows provided legal services to the Company through his legal firm, Bellows and Bellows P.C. The suit was filed in the Circuit Court of Cook County, Illinois and alleged the following: (i) Violation of Illinois Securities Act of 1953; (ii) Violation of Illinois Consumer Fraud Act; and (iii) Common Law Fraud, in connection with aggregate investments of $218,000 in the Company’s common stock claimed by Bastanipour and Bellows. They are seeking compensatory damages, costs and expenses. The Company does not believe Bastanipour and Bellows will prevail on any of the alleged complaints.

In March, 2010, the Company filed suit against Joel Bellows and Bellows and Bellows P.C. in the United States District Court for the District of New Mexico alleging the following: (i) Breach of Contract; (ii) Negligence; (iii) Breach of Fiduciary Duty; (iv) Fraud; and (v) Tortious Interference with Contract. The aforementioned complaints relate to legal services provided by Bellows and Bellows P.C. for the Company. The Company is seeking compensatory damages, punitive damages, interest, costs and fees.
 
 
CALDERA PHARMACEUTICALS, INC.

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS

16.  
LITIGATION (continued)

Seddie Bastanipour and Joel Bellows Suit (continued)

In December 2010, the Company filed suit against Seddie Bastanipour and Peter Baltrus for breach of contract and negligence when they were performing accounting services on behalf of the Company which resulted in an IRS penalty. In December, 2011, the Company completed an amicable settlement with Bastanipour and she is no longer party to either suit. Baltrus claims to have been working for Bellows (see above) at all relevant times; the case against Peter Baltrus continues. The Company has entered into further settlement discussions with Peter Baltrus .

17.  
SUBSEQUENT EVENTS

Series A 8% Convertible Preferred Stock and Common Stock Purchase Warrants
Subsequent to year end and in terms of a private placement memorandum dated June 24, 2011, a further  53,860 units of series A convertible preferred stock (“Preferred Stock”) and common stock purchase warrants were issued to Series A preferred stockholders at a par value of $0.001 per share for a total consideration of $307,000. A further 17,800 warrants were issued to advisors to acquire shares of common stock at a price of $5.70 per share in conjunction with the private placement.

Other than disclosed above, the Company has evaluated subsequent events through the date the financial statements were issued, and has concluded that no such events or transactions took place which would require disclosure herein.
 
 
F-24

 
REPORT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM


To the Board of Directors
Caldera Pharmaceuticals, Inc.


We have audited the accompanying balance sheets of Caldera Pharmaceuticals, Inc. as of December 31, 2010 and 2009 and the related statements of operations and changes in stockholders’ equity, and cash flows for the years then ended.  These financial statements are the responsibility of the Company's management. Our responsibility is to express an opinion on these financial statements based on our audits.

We conducted our audits in accordance with the standards of the Public Company Accounting Oversight Board (United States). Those standards require that we plan and perform the audit to obtain reasonable assurance about whether the financial statements are free of material misstatement. The Company is not required to have, nor were we engaged to perform, an audit of its internal control over financial reporting. Our audit included consideration of internal control over financial reporting as a basis for designing audit procedures that are appropriate in the circumstances, but not for the purpose of expressing an opinion on the effectiveness of the Company's internal control over financial reporting. Accordingly we express no such opinion. An audit includes examining, on a test basis, evidence supporting the amounts and disclosures in the financial statements. An audit also includes assessing the accounting principles used and significant estimates made by management, as well as evaluating the overall financial statement presentation. We believe that our audits provide a reasonable basis for our opinion.

In our opinion, the financial statements referred to above present fairly, in all material respects, the financial position of Caldera Pharmaceuticals, Inc. as of December 31, 2010 and 2009 and the results of their operations and their cash flows for the years then ended in conformity with accounting principles generally accepted in the United States of America.

 
 
/s/Sherb & Co., LLP
 
Certified Public Accountants
 
                                                   
Boca Raton, Florida
February 13, 2012
 
CALDERA PHARMACEUTICALS, INC.

CONSOLIDATED BALANCE SHEETS

   
December 31,
2010
   
December 31,
2009
 
ASSETS
           
             
Current assets:
           
Cash
  $ 117,910     $ 45,936  
Accounts receivable, net
    264,488       234,120  
Prepaid expenses
    3,010       46,728  
                 
Total current assets
    385,408       326,784  
                 
Non-current assets:
               
Intangible assets, net
    697,942       749,625  
Plant and equipment, net
    255,105       312,973  
                 
      953,047       1,062,598  
                 
TOTAL ASSETS
  $ 1,338,455     $ 1,389,382  
                 
                 
LIABILITIES AND STOCKHOLDERS’ EQUITY
               
                 
Current liabilities:
               
Accounts payable and accrued expenses
  $ 416,495     $ 167,833  
Loans payable
    116,084       82,257  
Loans from related parties
    77,600       -  
                 
Total current liabilities
    610,179       250,090  
                 
Non-current liabilities:
               
Loans payable
    270,952       299,251  
Loans from related parties
    -       11,000  
Loans from stockholders
    -       41,379  
                 
      270,952       351,630  
                 
TOTAL LIABILITIES
    881,131       601,720  
                 
Commitments and contingencies
               
                 
Stockholders’ equity:
               
Common stock, $0.001 par value, authorized 10,000,000  shares, 4,886,065 and 4,471,565 shares issued and outstanding as of December 31, 2010 and 2009, respectively.
        4,886           4,472  
Additional paid in capital
    4,112,316       3,578,187  
Accumulated deficit
    (3,659,878 )     (2,794,997 )
                 
Total stockholder’s equity
    457,324       787,662  
                 
TOTAL LIABILITIES AND STOCKHOLDERS EQUITY
  $ 1,338,455     $ 1,389,382  

See notes to the financial statements on pages F-5 through F-23
 
 
CALDERA PHARMACEUTICALS, INC.
 
CONSOLIDATED STATEMENTS OF OPERATIONS

   
Year ended
December 31,
2010
   
Year ended
December 31,
2009
 
             
Sales, net
  $ 1,641,582     $ 1,600,906  
                 
Cost of sales
    760,728       755,992  
Gross profit
    880,854       844,914  
                 
Operating expenses:
               
General and administrative expenses
    1,609,846       858,477  
Depreciation
    64,012       60,921  
Amortization
    51,683       51,683  
Total operating expenses
    1,725,541       971,081  
                 
Operating loss
    (844,687 )     (126,167 )
                 
Other income/(expense)
               
Other income
    -       3,460  
Interest income
    9       36  
Interest expense
    (20,203 )     (21,878 )
                 
Total other income/(expense)
    (20,194 )     (18,382 )
Loss before income tax
    (864,881 )     (144,549 )
                 
Provision for income taxes
    -       -  
                 
Net loss
  $ (864,881 )   $ (144,549 )
                 
Net loss per common stock:-
               
Basic and diluted
  $ (0.19 )   $ (0.03 )
                 
Weighted average number of common stock outstanding:-
               
Basic and diluted
    4,549,502       4,471,565  

See notes to the financial statements on pages F-5 through F-23
 
 
F-3

 
CALDERA PHARMACEUTICALS, INC.

CONSOLIDATED STATEMENT OF CHANGES IN STOCKHOLDER’S EQUITY
 
 
         
Common Stock
             
   
Number
of
shares
   
 
 
Amount
   
 
Additional
paid in capital
   
 
Accumulated deficit
   
Total Stockholder’s Equity
 
                               
Balance at January 1, 2009
    4,471,565     $ 4,472     $ 3,378,525     $ (2650,448 )   $ 732,549  
                                         
Fair value of stock options issued to employees
    -       -       199,662       -       199,662  
                                         
Net loss
            -       -       (144,549 )     (144,549 )
                                         
Balance at December 31, 2009
    4,471,565       4,472       3,578,187       (2,794,997 )     787,662  
                                         
Stock issued in terms of settlement agreement between shareholders  during October 2010
      90,000         90         33,950         -         34,040  
                                         
Issuance of common stock as compensation for consulting fees
    324,500       324       178,151       -       178,475  
                                         
Fair value of stock options issued to employees
    -       -       322,028       -       322,028  
                                         
Net loss
    -       -       -       (864,881 )     (864,881 )
                                         
Balance at December 31, 2010
    4,886,065     $ 4,886     $ 4,112,316     $ (3,659,878 )   $ 457,324  
 
See notes to the financial statements on pages F-5 through F-23
 
 
CALDERA PHARMACEUTICALS, INC.
 
CONSOLIDATED STATEMENTS OF CASH FLOWS
 
   
Year ended
December 31,
2010
   
Year ended
December 31,
2009
 
             
Cash flow from operating activities
           
Net loss
  $ (864,881 )   $ (144,549 )
Adjustments for non-cash items:
               
Depreciation
    64,012       60,921  
Amortization
    51,683       51,683  
Stock based compensation payments
    500,503       199,662  
                 
Changes in operating assets and liabilities:
               
Increase in accounts receivable
    (30,368 )     (130,926 )
Decrease in prepaid expenses
    43,718       15,087  
Increase in accounts payable and accrued expenses
    248,662       54,438  
                 
Net cash provided by operating activities
    13,329       106,316  
                 
Investing activities
               
Purchase of plant and equipment
    (6,144 )     (205,188 )
                 
Net cash used in investing activities
    (6,144 )     (205,188 )
                 
Financing activities
               
Advance on line of credit, net
    35,997       51,787  
Advance on loan payable
    -       4,956  
Repayment of loan payable
    (30,469 )     -  
Repayment of stockholders loan
    (7,339 )     (13,611 )
Loan advanced by stockholder
    66,600       -  
                 
Net cash provided by financing activities
    64,789       43,132  
                 
Net increase/(decrease) in cash
    71,974       (55,740 )
                 
Cash at the beginning of the period
    45,936       101,676  
                 
Cash at the end of the period
  $ 117,910     $ 45,936  
                 
Supplemental disclosure of cash flow information
               
Cash paid for:
               
Interest
  $ 20,203     $ 21,878  
                 
 
See notes to the financial statements on pages F-5 through F-23
 
 
CALDERA PHARMACEUTICALS, INC.
 
NOTES TO THE CONSOLIDATED FINANCIAL STATEMENTS
 
 
1.  
GENERAL INFORMATION

Caldera Pharmaceuticals, Inc. (“the Company”) is a Delaware corporation with principal offices in Los Alamos, New Mexico and Chicago, Illinois. The Company was incorporated in November 2003.

The Company is a drug discovery and pharmaceutical instrument company which is based on a proprietary x-ray fluorescence technology, called XRpro®. Caldera offers what it believes to be uniquely broad and simple technologies to evaluate drug molecules, which increases the efficiency of analyzing and evaluating drug molecules for safety and efficacy at an early and less expensive stage.

The Company has generated the majority of its revenues to date through Government research contracts and Government grants utilizing its proprietary x-ray fluorescence technology.
 
2.  
ACCOUNTING POLICIES AND ESTIMATES

Basis of Presentation
The accompanying financial statements have been prepared in conformity with accounting principles generally accepted in the United States of America (“US GAAP”).

Consolidation
The consolidated financial statements include the financial statements of the Company and its subsidiaries in which it has a majority voting interest. Investments in affiliates are accounted for under the cost method of accounting, where appropriate. All significant inter-company accounts and transactions have been eliminated in the consolidated financial statements. The entities included in these consolidated financial statements are as follows:

Caldera Pharmaceuticals, Inc (Parent Company)
XRpro Corp.

Estimates
The preparation of these financial statements in accordance with US GAAP requires us to make estimates and judgments that affect the reported amounts of assets, liabilities, revenues and expenses, and related disclosure of contingent assets and liabilities. We continually evaluate our estimates, including those related to bad debts, inventories, recovery of long-lived assets. We base our estimates on historical experience and on various other assumptions that we believed to be reasonable under the circumstances, the results of which form the basis for making judgments about the carrying values of assets and liabilities that are not readily apparent from other sources. Any future changes to these estimates and assumptions could cause a material change to our reported amounts of revenues, expenses, assets and liabilities. Actual results may differ from these estimates under different assumptions or conditions. We believe the following critical accounting policies affect our more significant judgments and estimates used in the preparation of the financial statements. Significant estimates include the allowance for doubtful accounts, the allowance for obsolete inventory, the useful life of property and equipment and intangible assets, and assumptions used in assessing impairment of long-term assets.

All amounts referred to in the notes to the financial statements are in United States Dollars ($) unless stated otherwise.

 
CALDERA PHARMACEUTICALS, INC.
 
NOTES TO THE CONSOLIDATED FINANCIAL STATEMENTS

 
2.  
ACCOUNTING POLICIES AND ESTIMATES (continued)

Contingencies
Certain conditions may exist as of the date the financial statements are issued, which may result in a loss to the Company but which will only be resolved when one or more future events occur or fail to occur. The Company’s management assesses such contingent liabilities, and such assessment inherently involves an exercise of judgment. In assessing loss contingencies related to legal proceedings that are pending against and by the Company or unasserted claims that may result in such proceedings, the Company’s management evaluates the perceived merits of any legal proceedings or unasserted claims as well as the perceived merits of the amount of relief sought or expected to be sought.
 
If the assessment of a contingency indicates that it is probable that a material loss has been incurred and the amount of the liability can be estimated, then the estimated liability would be accrued in the Company’s financial statements. If the assessment indicates that a potential material loss contingency is not probable but is reasonably possible, or is probable but cannot be estimated, then the nature of the contingent liability, together with an estimate of the range of possible loss if determinable and material would be disclosed.

Loss contingencies considered to be remote by management are generally not disclosed unless they involve guarantees, in which case the guarantee would be disclosed.

Fair value of financial instruments
The Company adopted the guidance of Accounting Standards Codification (“ASC”) 820 for fair value measurements which clarifies the definition of fair value, prescribes methods for measuring fair value, and establishes a fair value hierarchy to classify the inputs used in measuring fair value as follows:

Level 1-Inputs are unadjusted quoted prices in active markets for identical assets or liabilities available at the measurement date.
 
Level 2-Inputs are unadjusted quoted prices for similar assets and liabilities in active markets, quoted prices for identical or similar assets and liabilities in markets that are not active, inputs other then quoted prices that are observable, and inputs derived from or corroborated by observable market data.
 
Level 3-Inputs are unobservable inputs which reflect the reporting entity’s own assumptions on what assumptions the market participants would use in pricing the asset or liability based on the best available information.

The carrying amounts reported in the balance sheets for cash, accounts receivable, loans payable, accounts payable and accrued expenses, and advances to suppliers approximate their fair market value based on the short-term maturity of these instruments. The Company did not identify any assets or liabilities that are required to be presented on the balance sheets at fair value in accordance with the accounting guidance.
 
ASC 825-10 “ Financial Instruments ”, allows entities to voluntarily choose to measure certain financial assets and liabilities at fair value (fair value option). The fair value option may be elected on an instrument-by-instrument basis and is irrevocable, unless a new election date occurs. If the fair value option is elected for an instrument, unrealized gains and losses for that instrument should be reported in earnings at each subsequent reporting date. The Company did not elect to apply the fair value option to any outstanding instruments.
 
 
CALDERA PHARMACEUTICALS, INC.
 
NOTES TO THE CONSOLIDATED FINANCIAL STATEMENTS

 
2.  
ACCOUNTING POLICIES AND ESTIMATES (continued)

Recent accounting pronouncements
In October 2009, the FASB issued ASU No. 2009-14, “Certain Revenue Arrangements That Include Software Elements.” This ASU changes the accounting model for revenue arrangements that include both tangible products and software elements that are “essential to the functionality,” and scopes these products out of current software revenue guidance. The new guidance will include factors to help companies determine what software elements are considered “essential to the functionality.” The amendments will now subject software-enabled products to other revenue guidance and disclosure requirements, such as guidance surrounding revenue arrangements with multiple-deliverables. The amendments in this ASU are effective prospectively for revenue arrangements entered into or materially modified in the fiscal years beginning on or after June 15, 2010. Early application is permitted. The adoption of the new ASU did not have any important impact on the Company’s financial statements.

In January 2010, the FASB issued guidance to amend the disclosure requirements related to fair value measurements. The guidance requires the disclosure of roll forward activities on purchases, sales, issuance, and settlements of the assets and liabilities measured using significant unobservable inputs (Level 3 fair value measurements). The guidance will become effective for us with the reporting period beginning July 1, 2011. Other than requiring additional disclosures, the adoption of this new guidance will not have a material impact on our financial statements.

In January 2010, the FASB issued Accounting Standards Update ("ASU") No. 2010-06 for Fair Value Measurements and Disclosures (Topic 820):  Improving Disclosures about Fair Value Measurements . This Update requires new disclosures for transfers in and out of Level 1 and 2 and activity in Level 3. This Update also clarifies existing disclosures for level of disaggregation and requires additional disclosures about inputs and valuation techniques. The new disclosures are effective for interim and annual periods beginning after December 15, 2009, except for the Level 3 disclosures, which are effective for fiscal years beginning after December 15, 2010 and for interim periods within those years. Other than requiring additional disclosures, adoption of this new guidance did not have a material impact on the Company's financial statements and is not expected to have a significant impact on the reporting of the Company's financial condition or results of operations.

In February 2010, the FASB (Financial Accounting Standards Board) issued Accounting Standards Update 2010-09 (ASU 2010-09), Subsequent Events (Topic 855): Amendments to Certain Recognition and Disclosure Requirements.  This amendment addresses both the interaction of the requirements of this Topic with the SEC’s reporting requirements and the intended breadth of the reissuance disclosure provision related to subsequent events (paragraph 855-10-50-4).  All of the amendments in this Update are effective upon issuance of the final Update, except for the use of the issued date for conduit debt obligors. That amendment is effective for interim or annual periods ending after June 15, 2010.  The adoption of the new ASU did not have any important impact on the Company’s financial statements.

In March 2010, the FASB ratified the milestone method of revenue recognition. Under this standard, an entity can recognize contingent consideration earned from the achievement of a substantive milestone in its entirety in the period in which the milestone is achieved. A milestone is defined as an event (i) that can only be achieved based in whole or in part on either the entity's performance or on the occurrence of a specific outcome resulting from the entity's performance (ii) for which there is substantive uncertainty at the date the arrangement is entered into that the event will be achieved and (iii) that would result in additional payments being due to the entity. This guidance is effective for years beginning after June 15, 2010. This guidance did not have any important impact on the Company’s financial statements.

In   March 2010, the FASB issued ASU 2010-11, Derivatives and Hedging (Topic 815): Scope Exception Related to Embedded Credit Derivatives.  The amendments in this Update are effective for each reporting entity at the beginning of its first fiscal quarter beginning after June 15, 2010.  Early adoption is permitted at the beginning of each entity’s first fiscal quarter beginning after issuance of this Update.  The Company does not expect the provisions of ASU 2010-11 to have a material effect on the financial position, results of operations or cash flows of the Company.
 
 
CALDERA PHARMACEUTICALS, INC.
 
NOTES TO THE CONSOLIDATED FINANCIAL STATEMENTS
 
 
2.  
ACCOUNTING POLICIES AND ESTIMATES (continued)

Recent accounting pronouncements (continued)
In   April 2010, the FASB issued ASU 2010-13, Compensation-Stock Compensation (Topic 718): Effect of Denominating the Exercise Price of a Share-Based Payment Award in the Currency of the Market in Which the Underlying Equity Security Trades – a consensus of the FASB Emerging Issues Task Force.  The amendments in this Update are effective for fiscal years, and interim periods within those fiscal years, beginning on or after December 15, 2010.  Earlier application is permitted.  The Company does not expect the provisions of ASU 2010-13 to have a material effect on the financial position, results of operations or cash flows of the Company.

In May 2010, the FASB issued ASU 2010-19, Foreign Currency (Topic 830): Foreign Currency Issues: Multiple Foreign Currency Exchange Rates.  The amendments in this Update are effective as of the announcement date of March 18, 2010. The Company does not expect the provisions of ASU 2010-19 to have a material effect on the financial position, results of operations or cash flows of the Company.

In May 2011, the FASB issued guidance to amend the accounting and disclosure requirements on fair value measurements. The new guidance limits the highest-and-best-use measure to nonfinancial assets, permits certain financial assets and liabilities with offsetting positions in market or counterparty credit risks to be measured at a net basis, and provides guidance on the applicability of premiums and discounts. Additionally, the new guidance expands the disclosures on Level 3 inputs by requiring quantitative disclosure of the unobservable inputs and assumptions, as well as description of the valuation processes and the sensitivity of the fair value to changes in unobservable inputs. The new guidance will be effective for us beginning January 1, 2012. Other than requiring additional disclosures, we do not anticipate material impacts on our financial statements upon adoption.
 
In June 2011, the FASB issued guidance on presentation of comprehensive income. The new guidance eliminates the current option to report other comprehensive income and its components in the statement of changes in equity. Instead, an entity will be required to present either a continuous statement of net income and other comprehensive income or in two separate but consecutive statements. The new guidance will be effective for us beginning July 1, 2012 and will have presentation changes only.
 
Other accounting standards that have been issued or proposed by FASB that do not require adoption until a future date are not expected to have a material impact on the consolidated financial statements upon adoption.
 
Reporting by segment
No segmental information is presented as the Company only has one significant reporting segment which is Government Revenues.

Intangible assets

d)  
License Agreements
License agreements acquired by the Company are reported at acquisition value less accumulated amortization and impairments.
 
  b)   Amortization
Amortization is reported in the income statement straight-line over the estimated useful life of the intangible assets, unless the useful life is indefinite. Amortizable intangible assets are amortized from the date that they are available for use. The estimated useful life of the license agreement is twenty years which is the term of the patent supporting the underlying license agreements

Assessment of an intangible asset’s residual value and useful life is performed annually.

 
CALDERA PHARMACEUTICALS, INC.
 
NOTES TO THE CONSOLIDATED FINANCIAL STATEMENTS

 
2.  
ACCOUNTING POLICIES AND ESTIMATES (continued)

Plant and equipment
Plant and equipment is stated at cost less accumulated depreciation.  Depreciation is computed using straight-line method over the estimated useful lives of the assets. The estimated useful lives of the assets are as follows:

Leasehold improvements                                                                     5 Years
Laboratory equipment                                                                          7 Years
Furniture and fixtures                                                                           10 Years
Computer equipment                                                                            3 Years

The cost of repairs and maintenance is expensed as incurred; major replacements and improvements are capitalized. When assets are retired or disposed of, the cost and accumulated depreciation are removed from the accounts, and any resulting gains or losses are included in income in the year of disposition.

We examine the possibility of decreases in the value of fixed assets when events or changes in circumstances reflect the fact that their recorded value may not be recoverable. We recognize an impairment loss when the sum of expected undiscounted future cash flows is less than the carrying amount of the asset. The amount of impairment is measured as the difference between the asset’s estimated fair value and its book value.

Concentrations of credit risk
The Company’s operations are carried out in the USA. Accordingly, the Company’s business, financial condition and results of operations may be influenced by the political, economic and legal environment in the USA and by the general state of the economy. The Company’s results may be adversely affected by changes in governmental policies with respect to laws and regulations, anti-inflationary measures, and rates and methods of taxation, among other things.

Concentration of major customers
The Company currently derives substantially all of its revenues from Government research contracts.

During the year ended December 31, 2010, the Company recorded revenues from nine different research projects from Government agencies totaling 100% of its revenues. During the year ended December 31, 2009, the Company recorded revenues from ten different research projects from Government agencies totaling 100% of its revenues.

Accounts receivable and other receivables
We have a policy of reserving for uncollectible accounts based on our best estimate of the amount of probable credit losses in our existing accounts receivable.  We periodically review our accounts receivable and other receivables to determine whether an allowance is necessary based on an analysis of past due accounts and other factors that may indicate that the realization of an account may be in doubt.  Account balances deemed to be uncollectible are charged to the allowance after all means of collection have been exhausted and the potential for recovery is considered remote.

The amount charged to bad debt provision for the years ended December 31, 2010 and 2009 was $nil.

As a basis for accurately estimating the likelihood of collection has been established, we consider a number of factors when determining reserves for uncollectable accounts.   We believe that we use a reasonably reliable methodology to estimate the collectability of our accounts receivable. We review our allowances for doubtful accounts on a regular basis. We also consider whether the historical economic conditions are comparable to current economic conditions. If the financial condition of our customers or other parties that we have business relations with were to deteriorate, resulting in an impairment of their ability to make payments, additional allowances may be required.

 
CALDERA PHARMACEUTICALS, INC.
 
NOTES TO THE CONSOLIDATED FINANCIAL STATEMENTS

 
2.  
ACCOUNTING POLICIES AND ESTIMATES (continued)

Cash and cash equivalents
For purposes of the statements of cash flows, the Company considers all highly liquid instruments purchased with a maturity of three months or less and money market accounts to be cash equivalents. The Company maintains cash and cash equivalents with two financial institutions in the USA.  

Revenue recognition
Revenue sources consist of government grants, government contracts and commercial development contracts.
 
Revenues from government grants and contracts are for research and development purposes and are recognized in accordance with the terms of the award and the government agency. Grant revenue is recognized in one of two different ways depending on the grant. Cost reimbursement grants require us to submit proof of costs incurred that are invoiced by us to the government agency, which then pays the invoice. In this case, grant revenue is recognized during the period that the costs were incurred according to the terms of the government grant. Fixed cost grants require no proof of costs at the time of invoicing, but proof is required for audit purposes and grant revenue is recognized during the period that the costs were incurred according to the terms of the government grant. The grant revenue under these fixed costs grants is recognized using a percentage-of-completion method, which uses assumptions and estimates. These assumptions and estimates are developed in coordination with the principal investigator performing the work under the government fixed-cost grants to determine key milestones, expenses incurred, and deliverables to perform a percentage-of-completion analysis to ensure that revenue is appropriately recognized. Critical estimates involved in this process include total costs incurred and anticipated to be incurred during the remaining life of the grant.

Government contract revenue is recognized as allowable research and development expenses are incurred during the period and according to the terms of the government contract.

Commercial revenue is recognized when the service or development is delivered or upon complying with the relevant terms of the commercial agreement.

Sales and Marketing
Sales and marketing expenses are minimal at present. These costs, if any, are expensed as incurred and included in Selling, general and administrative expenses. The Company expects to incur substantial sales and marketing expenses in future periods to promote its x-ray florescence equipment to drug discovery enterprises.

Research and Development
The remuneration of the Company’s research and development staff, materials used in internal research and development activities, and payments made to third parties in connection with collaborative research and development arrangements, are all expensed as incurred.  Where the company makes a payment to a third party to acquire the right to use a product formula which has received regulatory approval, that payment is accounted for as the acquisition of a license or patent and is capitalized as an intangible asset and amortized over the shorter of the remaining license period or patent life.

The amount expensed for research costs during the year and the prior year is immaterial.

Patent Costs
Legal costs in connection with approved patents and patent applications are expensed as incurred and classified as selling, general and administrative expense in our consolidated statement of operations.
 
 
F-11

 
CALDERA PHARMACEUTICALS, INC.
 
NOTES TO THE CONSOLIDATED FINANCIAL STATEMENTS
 
 
2.  
ACCOUNTING POLICIES AND ESTIMATES (continued)

Share-Based Compensation
Share-based compensation cost is measured at the grant date, based on the estimated fair value of the award and is recognized as expense over the employee's requisite service period on a straight-line basis. Share-based compensation expense recognized in the consolidated statements of operations for the years ended December 31, 2010 and 2009 is based on awards ultimately expected to vest and has been reduced for estimated forfeitures. This estimate will be revised in subsequent periods if actual forfeitures differ from those estimates. We have no awards with market or performance conditions.

Income Taxes
The Company utilizes SFAS No. 109, Accounting for Income Taxes, included in the Codification as ASC 740, Income Taxes, which requires the recognition of deferred tax assets and liabilities for the expected future tax consequences of events that have been included in the financial statements or tax returns. Under this method, deferred income taxes are recognized for the tax consequences in future years of differences between the tax bases of assets and liabilities and their financial reporting amounts at each period end based on enacted tax laws and statutory tax rates applicable to the periods in which the differences are expected to affect taxable income. Valuation allowances are established, when necessary, to reduce deferred tax assets to the amount expected to be realized.

Net Loss per Share
Basic net loss per share is computed on the basis of the weighted average number of common stock outstanding during the period.

Diluted net income per share is computed on the basis of the weighted average number of common stock and common stock equivalents outstanding. Dilutive securities having an anti-dilutive effect on diluted net income per share are excluded from the calculation.

Dilution is computed by applying the treasury stock method for options and warrants. Under this method, options and warrants are assumed to be exercised at the beginning of the period (or at the time of issuance, if later), and as if funds obtained thereby were used to purchase common stock at the average market price during the period.

Dilution is computed by applying the if-converted method for convertible preferred stocks. Under this method, convertible preferred stock is assumed to be converted at the beginning of the period (or at the time of issuance, if later), and preferred dividends (if any) will be added back to determine income applicable to common stock. The shares issuable upon conversion will be added to weighted average number of common stock outstanding. Conversion will be assumed only if it reduces earnings per share (or increases loss per share).

Comprehensive income
Comprehensive income is defined as the change in equity of a company during a period from transactions and other events and circumstances excluding transactions resulting from investments from owners and distributions to owners. For the Company, comprehensive income for the periods presented includes net income.

 
F-12

 
CALDERA PHARMACEUTICALS, INC.
 
NOTES TO THE CONSOLIDATED FINANCIAL STATEMENTS
 
 
2.  
ACCOUNTING POLICIES AND ESTIMATES (continued)

Related parties
Parties are considered to be related to the Company if the parties that, directly or indirectly, through one or more intermediaries, control, are controlled by, or are under common control with the Company. Related parties also include principal owners of the Company, its management, members of the immediate families of principal owners of the Company and its management and other parties with which the Company may deal if one party controls or can significantly influence the management or operating policies of the other to an extent that one of the transacting parties might be prevented from fully pursuing its own separate interests. The Company shall disclose all related party transactions. All transactions shall be recorded at fair value of the goods or services exchanged. Property purchased from a related party is recorded at the cost to the related party and any payment to or on behalf of the related party in excess of the cost is reflected as a distribution to related party.

3.  
GOING CONCERN

As shown in the accompanying financial statements, the Company incurred a net loss of $864,881 and $144,549 during the years ended December 31, 2010 and 2009, respectively. As of December 31, 2010, the Company had an accumulated deficit of $3,659,878. The Company had a working capital deficiency of $224,771 at December 31, 2010. These operating losses and working capital deficiency create an uncertainty about the Company’s ability to continue as a going concern. Although no assurances can be given, management of the Company believes that potential additional issuances of equity or other potential financing will provide the necessary funding for the Company to continue as a going concern. The financial statements do not include any adjustments that might be necessary if the Company is unable to continue as a going concern. The Company is economically dependent upon future capital contributions or financing to fund ongoing operations.

4.  
INTANGIBLE ASSETS

Licenses
In terms of an Exclusive Patent License agreement covering national and international patents entered into with the Los Alamos National Security LLC. Dated September 8, 2005, the Company has the exclusive right to the use of certain patents covering the following:

·  
Method for Detecting Binding Events Using Micro X-Ray Fluorescence Spectrometry;
·  
Flow Method and Apparatus for Screening Chemicals Using Micro X-Ray Fluorescence;
·  
Method and Apparatus for Detecting Chemical Binding;
·  
Drug Development and Manufacturing.

The agreement provides for a term as long as the last surviving patent which is generally a twenty year period from the date of first application.

 
CALDERA PHARMACEUTICALS, INC.
 
NOTES TO THE CONSOLIDATED FINANCIAL STATEMENTS
 

4.  
INTANGIBLE ASSETS (continued)

In terms of the agreement, The Company issued shares to the Licensor equal to 3% of the issued equity of the Company. The agreement contains anti-dilutive clauses which will ensure that the Licensor maintains at least a 3% shareholding in the Company until the Company achieves equity financing of at least $20 million.  As of December 31, 2010, the Company has not yet raised the requisite amount of financing.  The Licensor continued to hold, at a minimum, 3% of the Company’s common stock.
 
The agreement further provides for an annual royalty to be paid to the Licensee at a rate of 2% per annum on net sales, excluding any sales to Government agencies. The agreement provided for a minimum royalty payment of $25,000 per annum for the financial years ended December 31, 2006 to December 31, 2010. Thereafter the minimum royalty payment increases to $50,000 per annum up until December 31, 2022.

   
December 31,
2010
   
December 31,
2009
 
             
Licenses, at cost
  $ 972,000     $ 972,000  
Less: Accumulated amortization
    (274,058 )     (222,375 )
                 
    $ 697,942     $ 749,625  

The aggregate amortization expense charged to operations was $51,683 and $51,683 for the years ended December 31, 2010 and 2009, respectively. The amortization policies followed by the company are described in Note (2).

Amortization expense for the future years is summarized as follows:

   
Amount
 
       
2011
  $ 51,684  
2012
    51,684  
2013
    51,684  
2014
    51,684  
2015
    51,684  
2016 and thereafter
    439,522  
Total
  $ 697,942  

Patents
The Company has various patents pending or registered in its name. These patents have been internally generated and all costs associated with the research and development of these patents has been expensed.

The patents assigned to Caldera are as follows:

·  
Well Plate – apparatus for preparing samples for measurement by x-ray fluorescence spectrometry. Patent filed August 15, 2008
·  
Method and Apparatus for measuring Protein Post Translational Modification. Patent filed September 26, 2008.
·  
Method and Apparatus for Measuring Analyte Transport across barriers. Patent filed July 1, 2009.
 
 
CALDERA PHARMACEUTICALS, INC.
 
NOTES TO THE CONSOLIDATED FINANCIAL STATEMENTS
 
 
5.  
PLANT AND EQUIPMENT

Plant and equipment consists of the following at December 31, 2010 and 2009.

   
December 31,
2010
   
December 31,
2009
 
             
Leasehold improvements
  $ 6,393     $ 6,393  
Furniture and fittings
    7,114       7,114  
Laboratory equipment
    413,269       411,676  
Computer equipment
    22,439       17,888  
                 
Total
    449,215       443,071  
Accumulated depreciation
    (194,110 )     (130,098 )
    $ 255,105     $ 312,973  

The aggregate depreciation charge to operations was $64,012 and $60,921 for the years ended December 31, 2010 and 2009 respectively. The depreciation policies followed by the company are described in Note (2).

6.  
ACCOUNTS PAYABLE AND ACCRUED EXPENSES

   
December 31,
2010
   
December 31,
2009
 
             
Accounts payable
  $ 290,891     $ 57,753  
Credit card liabilities
    2,342       25,502  
Vacation and Sick Pay accrual
    85,228       64,339  
Payroll liabilities
    28,489       20,239  
Other
    9,545       -  
                 
    $ 416,495     $ 167,833  
 
 
CALDERA PHARMACEUTICALS, INC.
 
NOTES TO THE CONSOLIDATED FINANCIAL STATEMENTS

7.  
INCOME TAXES

Due to our historical net loss position, and  valuation allowance against deferred tax assets, there is no provision or benefit for income taxes recorded for the years ended December 31, 2010 and 2009.

The income tax provision/ (benefit) is different from that which would be obtained by applying the statutory Federal income tax rate of 35% to income before income tax expense. The items causing this difference for the years ended December 31, 2010 and 2009 are as follows:

   
December 31,
2010
   
December 31,
2009
 
             
Income tax benefit at federal statutory rate
  $ (302,709 )   $ (50,592 )
State taxes, net of federal benefit
    (43,244 )     (7,227 )
Other
    (53,748 )     -  
 Stock based compensation
    200,201       79,864  
      (199,500 )     22,045  
Valuation allowances
    199,500       (22,045 )
    $ -     $ -  

Deferred income taxes reflect the net tax effect of temporary differences between the carrying amount of assets and liabilities for financial reporting purposes and the amounts used for income tax purposes. Significant components of deferred tax assets and liabilities at December 31, 2010 and 2009 are as follows:

   
December 31,
2010
   
December 31,
2009
 
Deferred tax assets
           
Accrual to cash adjustments
  $ 60,000     $ -  
Plant and equipment
    10,500       28,000  
Net operating loss
    697,000       580,000  
      767,500       608,000  
Valuation allowance
    (695,500 )     (496,000 )
Net Amortization
    72,000       112,000  
Deferred tax liabilities
               
Accrual to cash adjustments
    (72,000 )     (67,000 )
    $ -     $ -  
                 
 
 
CALDERA PHARMACEUTICALS, INC.
 
NOTES TO THE CONSOLIDATED FINANCIAL STATEMENTS
 
 
7.  
INCOME TAXES (continued)

We have established a valuation allowance against our gross deferred tax assets sufficient to bring our net deferred tax assets to zero due to the uncertainty surrounding the realization of such assets. Management has determined it is more likely than not that the deferred tax assets are not realizable beyond our deferred tax liabilities due to our historical loss position.

At December 31, 2010, we had tax loss carry forwards of approximately $1,743,000. These net operating loss carry forwards begin to expire in 2023, if unused.

Pursuant to the Internal Revenue Code of 1986, as amended, ("IRC") §382, our ability to use net operating loss carry forwards to offset future taxable income is limited if we experience a cumulative change in ownership of more than 50% within a three-year period.

The Company’s 2009 and 2010 Federal income tax returns have been examined by the Internal Revenue Service (“IRS”) and the adjustments proposed by the IRS were agreed to by the Company. The Company’s tax provision reflects the IRS’ audit adjustments and the Com,pany believes that there are no remaining uncertain tax positions requiring recognition.

8.  
LOANS PAYABLE

   
December 31,
2010
   
December 31,
2009
 
Short term  portion
           
Los Alamos County Loan
  $ 28,300     $ 30,469  
Los Alamos National Bank – Loan 1
    -       51,788  
Los Alamos National Bank – Loan 2
    87,784       -  
                 
      116,084       82,257  
Long term portion
               
Los Alamos County Loan
    270,952       299,251  
                 
    $ 387,036     $ 381,508  
 
 
 
CALDERA PHARMACEUTICALS, INC.
 
NOTES TO THE CONSOLIDATED FINANCIAL STATEMENTS

8.  
LOANS PAYABLE (continued)

Los Alamos County Loan
The Company entered into a Project Participation Agreement (as Amended) and a Loan Agreement with the Incorporated County of Los Alamos as of September 21, 2006. The Agreement provided for funding up to a maximum of $2,200,000 for the construction of a building and purchase of equipment. The maximum amount of equipment to be funded out of the total available loan of $2,200,000 was $625,000. The term of the loan is 13 years. The loan agreement provided for no repayments for 36 months with 120 equal monthly repayments commencing on September 21, 2009. The interest rate on the loan is 5% per annum. The assets funded in terms of the Project Participation Agreement and the Loan Agreement is to be used as security for the balance of the loan outstanding.

The Company made use of the loan to purchase assets amounting to $302,009 during the 2007 financial year. Repayments of the loan commenced on September 21, 2009 at an interest rate of 5% per annum with equal monthly repayments of $3,546.87.

Los Alamos National Bank – Loan 1
The Company entered into a one year revolving draw loan with Los Alamos National Bank as of April 23, 2009 with a principal available of $300,000. The Company drew $50,000 on the loan on April 23, 2009, a further $50,000 on May 24, 2009 a further $60,000 on June 29, 2009 and a further $40,000 on July 13, 2009. The Company made repayments on the loan on October 27, 2009 of $50,000 , a further repayment of $100,000 was made on December 31, 2009 and a final repayment of $50, 000 on April 23, 2010. The loan bears interest at a coupon of the Wall Street Journal Prime rate plus 1% with a floor of 6% per annum. This loan is secured by inventory, Accounts receivable and other rights to payments, instruments, documents and other Chattel paper, general intangibles and fixed assets. Interest is payable quarterly.

Los Alamos National Bank – Loan 2
The Company entered into a one year revolving draw loan with Los Alamos National Bank as of April 23, 2010 with a principal available of $300,000. The Company drew $86,800 on the loan on April 23, 2010, utilizing $50,000 to repay the balance outstanding on loan 1 above. The loan bears interest at a coupon of the Wall Street Journal Prime rate plus 1% with a floor of 6% per annum. This loan is secured by inventory, accounts receivable and other rights to payments, instruments, documents and other Chattel paper, general intangibles and fixed assets. Interest is payable quarterly.

9.  
LOANS FROM STOCKHOLDERS

The loan from shareholders represents a loan from one shareholder; the loan is interest free and has no fixed terms of repayment.

In terms of a settlement agreement reached between shareholders of the Company and the Company, the remaining balance of the loan of $34,040 in October 2010 was forgiven. (See note 9 below).
 
 
CALDERA PHARMACEUTICALS, INC.
 
NOTES TO THE CONSOLIDATED FINANCIAL STATEMENTS

10.  
COMMON STOCK

Common stock consists of 10,000,000 authorized shares of $0.001 each.

In terms of  settlement agreement entered into between three existing shareholders of the company and a further settlement agreement entered into between The Company and these shareholders, a further 90,000 shares were issued to two existing shareholders in exchange for their judgment and settlement agreement obtained against the third shareholder. The agreement entitles the company to redeem 177,500 shares of common stock of the third shareholder and a forgiveness of a debt owing to the third shareholder of $34,040. The cancellation of the 177,500 shares will only take place in 2011 once a Stay and Collection Judgment obtained against Caldera Pharmaceuticals by our previous legal counsel has been dismissed. This dismissal was obtained in November 2011.

11.  
STOCK BASED COMPENSATION
 
In October 2005, the Company's Board of Directors adopted the Caldera Pharmaceuticals, Inc. 2005 Stock Option Plan (the "Plan"), which permits awards of incentive and nonqualified stock options and other forms of incentive compensation to employees and non-employees such as directors and consultants. The Board has 3,000,000 shares of common stock for issuance upon exercise of grants made under the Plan. Options granted under the Plan vest either immediately or over a period of up to two years, and expire 4 years to 10 years from the grant date. At December 31, 2010, 2,064,500 shares were available for future grant under the Incentive Plan.
 
Stock-based compensation expense totaled $322,028 and $199,662 in 2010 and 2009, respectively. The Company expenses the value of stock options as earned. The fair value of the options granted is determined using the Black-Scholes option-pricing model. The following weighted average assumptions were used:

   
Year ended
December 31,
2010
   
Year ended
December 31,
2009
 
             
Risk-free interest rate
 
0.04% to 0.15%
      0.15% - 0.17%  
Expected life of the options   5 Years     5 Years  
Expected volatility of the underlying stock
    128%       129%  
Expected dividend rate
    0%       0%  
 
As noted above, the fair value of stock options is determined by using the Black-Scholes option pricing model. For all options granted since October 1, 2005 the Company has generally used option terms of between 4 to 10 years, with 5 years representing the estimated life of options granted. The volatility of the common stock is estimated using historical data of companies similar in size and in the same industry as Caldera Pharmaceuticals.  The risk-free interest rate used in the Black-Scholes option pricing model is determined by reference to historical U.S. Treasury constant maturity rates with short term maturities of no more than three months. An expected dividend yield of zero is used in the option valuation model, because the Company does not expect to pay any cash dividends in the foreseeable future. At December 31, 2010, the Company does not anticipate any awards will be forfeited in the calculation of compensation expense due to the limited number of employees that receive stock option grants.
 
 
CALDERA PHARMACEUTICALS, INC.
 
NOTES TO THE CONSOLIDATED FINANCIAL STATEMENTS
 
 
11.  
STOCK BASED COMPENSATION (continued)

No options were exercised during the 2010 or the 2009 periods.

We canceled options exercisable for 57,188 and 10,312 shares of common stock in the years ended December 31, 2010 and 2009, respectively, held by employees whose service to our company terminated during those respective periods. The shares underlying such options were returned to and are available for re-issuance under the 2005 Plan pursuant to the terms described above.
 
During the years ended December 31, 2010 and 2009, all awards granted under the Plan were incentive stock options. A summary of all of our option activity as of December 31, 2010 and 2009 and of changes in options outstanding under the plans during the year ended December 31, 2010 are as follows:
 
   
 
Shares
   
Exercise price per share
   
Weighted average exercise price
 
                   
Outstanding, January 1, 2009
    218,000     $ 2.00 – $5.71     $ 4.52  
Granted
    70,000     $ 5.71     $ 5.71  
Forfeited/Cancelled
    (10,312 )   $ 5.71     $ 5.71  
Exercised
    -       -       -  
                         
Outstanding December 31, 2009
    277,688     $ 2.00 - $5.71     $ 4.77  
Granted
    65,000     $ 5.71     $ 5.71  
Forfeited/Cancelled
    (57,188 )   $ 2.00 - $5.71     $ 4.09  
Exercised
    -       -       -  
                         
Outstanding December 31, 2010
    285,500     $ 2.00 - $5.71     $ 5.13  

The following tables summarize information about stock options outstanding at December 31, 2010:
 
     
Options Outstanding
   
Options Exercisable
 
 
 
 
 
Exercise Price
   
 
 
 
Number of shares
   
Weighted average remaining contractual years
   
 
 
Weighted Average Exercise Price
   
 
 
 
Number of Shares
   
 
 
Weighted Average exercise Price
 
                                 
$ 2.00       45,000       4.86     $ 2.00       45,000     $ 2.00  
$ 5.71       240,500       7.67     $ 5.71       155,500     $ 5.71  
                                             
          285,500       7.23     $ 5.13       200,500     $ 4.88  

The weighted-average grant-date fair values of options granted during 2010 and 2009 were $4.84 and $4.86, respectively. As of December 31, 2010 there were unvested options to purchase 85,000 shares of common stock. Total expected unrecognized compensation cost related to such unvested options is $333,516, which is expected to be recognized over a weighted–average period of 8 months
 
 
CALDERA PHARMACEUTICALS, INC.
 
NOTES TO THE CONSOLIDATED FINANCIAL STATEMENTS
 
 
12.  
NET LOSS PER COMMON SHARE

Basic loss per share is based on the weighted-average number of common shares outstanding during each period. Diluted loss per share is based on basic shares as determined above plus the incremental shares that would be issued upon the assumed exercise of in-the-money stock options and warrants using the treasury stock method. The computation of diluted net loss per share does not assume the issuance of common shares that have an anti-dilutive effect on net loss per share. For the years ended December 31, 2010 and 2009, all stock options were excluded from the computation of diluted net loss per share. Dilutive shares which could exist pursuant to the exercise of outstanding stock instruments and which were not included in the calculation because their affect would have been anti-dilutive are as follows:
 
   
Year ended
December 31,
2010
(Shares)
   
Year ended
December 31,
2009
(Shares)
 
             
Options to purchase shares of common stock
    285,500       277,688  

13.  
RELATED PARTY TRANSACTIONS

The majority of the share in the Company is owned by Benjamin Warner, the Chief Executive Officer. As at December 31, 2010 and 2009 respectively, Benjamin Warner owned 65.7% and 71.8% respectively.

Loans from related parties

   
December 31,
2010
   
December 31,
2009
 
Short term loans
           
Benjamin P Warner
  $ 77,600     $ -  
                 
Long term loans
               
Benjamin P Warner
    -       11,000  
    $ 77,600     $ 11,000  

The loan from Benjamin Warner is interest free and has no fixed repayment terms. Subsequent to year end, the balance outstanding on the loan was converted to units consisting of Preferred stock and warrants.
 
 
CALDERA PHARMACEUTICALS, INC.
 
NOTES TO THE CONSOLIDATED FINANCIAL STATEMENTS
 
 
14.  
OPERATING LEASES

The Company extended its existing office lease effective November 1, 2010. The monthly rent amounts to $4,784 per month and the lease terminates in October 2013.

The Company entered into an office sub-lease agreement with Greg Rzepczynski & Assiciates, LTD effective September1, 2011. The monthly rent amounts to $4,000 per month and the lease expires in September 2012.

Future annual minimum payments required under operating lease obligations at December 31, 2010, are as follows:

   
Amount
 
       
2011
  $ 73,695  
2012
    95,426  
2013
    50,753  
Total
  $ 219,874  

15.  
LITIGATION

Los Alamos National Security Suit

In October 2010, the Company filed suit against Los Alamos National Security LLC (“LANS”) and seven other co-defendants in the United States District Court For the Northern District of Illinois Eastern Division alleging the following: (i) Breach of Contract; (ii) Fraud; (iii) Intentional Interference with Contractual Relations; (iii) Legal Malpractice; and other related claims in connection with an exclusive Patent Licensing Agreement (the “Agreement”) originally entered into between the Company and the Regents of the University of California (the “Regents”) in September 2005. In April 2006, the Regents assigned the Agreement to LANS. The Company believes the defendants made false representations that were critical to its decision to enter into the Agreement including: (i) the Regents was the lawful owner of the patent rights covered by the Agreement; and (ii) the Regents would prosecute and maintain these patent rights and notify the Company if it decided to abandon them. The Company also believes that LANS and other co-defendants improperly competed with the Company. In addition, the Company believes that two of the co-defendants, both in-house patent attorneys for LANS, breached their professional duties. The Company believes it has suffered substantial damages from the defendants’ actions. The Company also filed suit against the Regents and LANS in California Superior Court in San Francisco in December 2007. This suit was dismissed for reason of lack of subject matter jurisdiction by the Court. We believe that this dismissal was made incorrectly, and are appealing this ruling. The defendants filed countersuits, which were also dismissed. Should LANS or other defendants file or re-file countersuits, the Company intends to vigorously defend itself.
 
 
CALDERA PHARMACEUTICALS, INC.
 
NOTES TO THE CONSOLIDATED FINANCIAL STATEMENTS
 
 
15.  
LITIGATION (continued)

Los Alamos National Security Suit (continued)

In September 2011, the Company filed suit against the Regents of the University of California and Los Alamos National Security LLC ("LANS") in the Circuit Court of Cook County. LANS removed the case to federal court, Case # ll-CV-07259. The Company's complaint alleges the following: (i) Breach of Contract; (ii) Breach of the Implied Covenant of Good Faith; (iii) Fraud; and (iv) Fraudulent Inducement, in connection with an exclusive Patent Licensing Agreement (the "Agreement") originally entered into between the Company and the Regents of the University of California (the "Regents") in September 2005 and assigned to LANS in April 2006. The Company believes the defendants breached a License Agreement, and made false representations that were critical to the Company's decision to enter into the Agreement. The Company believes it has suffered substantial damages from the Defendants' actions.

Seddie Bastanipour and Joel Bellows Suit

In October 2008, Seddie Bastanipour and Joel Bellows filed suit against the Company, our Chief Executive Officer, Dr. Benjamin Warner, and a former consultant to the Company, Sigmund Eisenchenk. Joel Bellows provided legal services to the Company through his legal firm, Bellows and Bellows P.C. The suit was filed in the Circuit Court of Cook County, Illinois and alleged the following: (i) Violation of Illinois Securities Act of 1953; (ii) Violation of Illinois Consumer Fraud Act; and (iii) Common Law Fraud, in connection with aggregate investments of $218,000 in the Company’s common stock claimed by Bastanipour and Bellows. They are seeking compensatory damages, costs and expenses. The Company does not believe Bastanipour and Bellows will prevail on any of the alleged complaints.

In March, 2010, the Company filed suit against Joel Bellows and Bellows and Bellows P.C. in the United States District Court for the District of New Mexico alleging the following: (i) Breach of Contract; (ii) Negligence; (iii) Breach of Fiduciary Duty; (iv) Fraud; and (v) Tortious Interference with Contract. The aforementioned complaints relate to legal services provided by Bellows and Bellows P.C. for the Company. The Company is seeking compensatory damages, punitive damages, interest, costs and fees.

In December 2010, the Company filed suit against Seddie Bastanipour and Peter Baltrus for breach of contract and negligence when they were performing accounting services on behalf of the Company which resulted in an IRS penalty. In December, 2011, the Company completed an amicable settlement with Bastanipour and she is no longer party to either suit. Baltrus claims to have been working for Bellows (see above) at all relevant times; the case against Peter Baltrus continues. The Company has entered into further settlement discussions with Peter Baltrus .
 
 
 
CALDERA PHARMACEUTICALS, INC.
 
NOTES TO THE CONSOLIDATED FINANCIAL STATEMENTS

16.  
SUBSEQUENT EVENTS

Series A 8% Convertible Preferred Stock and Common Stock Purchase Warrants
Subsequent to year end and in terms of a private placement memorandum dated June 24, 2011, 341,607 units of series A convertible preferred stock (“Preferred Stock”) and common stock purchase warrants were issued to Series A preferred stockholders at a par value of $0.001 per share for a total consideration of $1,947,150. A further 57,800 warrants were issued to advisors to acquire shares of common stock at a price of $5.70 per share in conjunction with the private placement. The Preferred Stock will convert to common stock of the company at a price of $5.70 per Common Stock subject to adjustment for stock splits, stock dividends and any further recapitalizations. The Preferred Stock is subject to voluntary conversion at the option of the stockholder at any time and is mandatory convertible at the option of the Company provided the Company’s common stock is trading on a recognized stock exchange or Over the Counter Bulletin Board and the volume weighted average price of the Company’s common stock is at least $10 per share, subject to stock splits, stock dividends and recapitalizations.

The Preferred Stock Holders will receive warrants to purchase shares of the Company’s common stock equal to 100% of the number of shares that they would receive upon conversion of the Preferred stock into common stock at an exercise price of $5.70 per share. The Warrants will expire five years after date of issuance. The Warrants are not transferable separately from the Preferred Stock without the consent of the Company and an opinion of Counsel satisfactory to the Company.

Should the Company receive net proceeds of at least $3 million from litigation proceedings against the managers of Los Alamos National Laboratory; the Preferred Stock holder will have the option to redeem the Preferred Stock equal to 130% of the price per share of $5.70. The Company also has the option to redeem the Preferred Stock at a price equal to 130% of the price per share of $5.70 at any time after giving the investors notice and allowing them to exercise their conversion rights into common stock 30 days after notice has been received.

The Preferred stock carries an 8% cumulative, non-compounded dividend payable on January 31, each year. In cash or in kind at the option of the Preferred Stock holder. For any other dividends or distributions, the Preferred Stock is treated on an as converted basis.

Other than disclosed above, the Company has evaluated subsequent events through the date the financial statements were issued, and has concluded that no such events or transactions took place which would require disclosure herein.


 
 
PA RT II
 
INFORMATION NOT REQUIRED IN PROSPECTUS
 

Item 13.   Other Expenses of Issuance and Distribution.
 
We estimate that expenses in connection with the distribution described in this registration statement (other than brokerage commissions, discounts or other expenses relating to the sale of the shares by the selling security holders) will be as set forth below. We will pay all of the expenses with respect to the distribution, and such amounts, with the exception of the Securities and Exchange Commission (“SEC”) registration fee, are estimates.
 
SEC registration fee
 
$
772.55
 
Accounting fees and expenses
   
10,000
 
Legal fees and expenses
 
25,000
 
Printing and related expenses
 
$
5,000
 
Transfer agent fees and expenses
   
2,000
 
Miscellaneous
   
2,227.45
 
Total
 
$
45,000
 
 
Item 14.   Indemnification of Directors and Officers.
 
Pursuant to our Second Amended and Restated Articles of Incorporation, our Board of Directors may issue additional shares of common or preferred stock. Any additional issuance of common stock or the issuance of preferred stock could have the effect of impeding or discouraging the acquisition of control of us by means of a merger, tender offer, proxy contest or otherwise, including a transaction in which our stockholders would receive a premium over the market price for their shares, and thereby protects the continuity of our management.  Specifically, if in the due exercise of its fiduciary obligations, the Board of Directors was to determine that a takeover proposal was not in our best interest, shares could be issued by the Board of Directors without stockholder approval in one or more transactions that might prevent or render more difficult or costly the completion of the takeover by:
 
·  
diluting the voting or other rights of the proposed acquirer or insurgent stockholder group;
   
·  
putting a substantial voting block in institutional or other hands that might undertake to support the incumbent board of directors; or
   
·  
effecting an acquisition that might complicate or preclude the takeover.
 
The Delaware Corporations and Associations Act (“Delaware Corporate Law”), with certain exceptions, permits a Delaware corporation to indemnify a present or former director or officer of the corporation (and certain other persons serving at the request of the corporation in related capacities) for liabilities, including legal expenses, arising by reason of service in such capacity if such person shall have acted in good faith and in a manner he reasonably believed to be in, or not opposed, to the best interests of the corporation, and in any criminal proceeding if such person had no reasonable cause to believe his conduct was unlawful. However, in the case of actions brought by or in the right of the corporation, no indemnification may be made with respect to any matter as to which such director or officer shall have been adjudged liable, except in certain limited circumstances.
 
Our Second Amended and Restated Articles of Incorporation provide that we shall indemnify our directors and executive officers to the fullest extent now or hereafter permitted by Delaware Corporate Law. The indemnification provided by Delaware Corporate Law and our Second Amended and Restated Certificate of Incorporation is not exclusive of any other rights to which a director or officer may be entitled. The general effect of the foregoing provisions may be to reduce the circumstances under which an officer or director may be required to bear the economic burden of the foregoing liabilities and expense.
 
We may also purchase and maintain insurance for the benefit of any director or officer that may cover claims for which we could not indemnify such person.
 
 
Insofar as indemnification for liabilities arising under the Securities Act of 1933 (the “Securities Act”) may be permitted to our directors, officers and controlling persons, we have been advised that, in the opinion of the SEC, such indemnification is against public policy as expressed in the Securities Act and is, therefore, unenforceable.
 
In the event that a claim for indemnification against such liabilities is asserted by one of our directors, officers, or controlling persons in connection with the securities being registered, we will, unless in the opinion of our legal counsel the matter has been settled by controlling precedent, submit the question of whether such indemnification is against public policy to court of appropriate jurisdiction. We will then be governed by the court's decision.
  
Item 15.   Recent Sales and Issuances of Unregistered Securities.
 
In April 2009 we issued options to one individual (the “April 2009 Options”) for services rendered exercisable for a period of ten years for 50,000 shares of common stock and in October 2009 we issued options (the “October 2009 Options”) to one individual for services rendered exercisable for ten years for 20,000 shares of common stock.  The exercise price of both issuances was $5.71 per share.  The options vested 50% after one year and 12.5% quarterly thereafter, with all options vesting in 2011. The issuance of the options qualified for exemption under Section 4(2) of the Securities Act since the issuance by the Company did not involve a public offering. The issuance was not a public offering as defined in Section 4(2) because the offer and sale was made to an insubstantial number of persons and because of the manner of the offering. In addition, the investors had the necessary investment intent as required by Section 4(2) since they agreed to, and received, certificates bearing a legend stating that such options and the underlying shares are restricted. This restriction ensured that these securities will not be immediately redistributed into the market and therefore be part of a public offering. This issuance was done with no general solicitation or advertising by the Company. Based on an analysis of the above factors, the Company met the requirements to qualify for exemption under Section 4(2) of the Securities Act for the transactions.
 
In January 2010 we issued options to two individuals (the “January 2010 Options”) for services rendered exercisable for a period of ten years for an aggregate of 40,000 shares of common stock and in July 2010 we issued options(the “July 2010 Options”) to two individuals for services rendered exercisable for ten years for an aggregate of 25,000 shares of common stock. The exercise price of both issuances was $5.71 per share. The options vested 50% after one year and 12.5% quarterly thereafter, with all of the January 2010 Options being fully vested and the July 2010 Options being fully vested in July 2012. The issuance of the options qualified for exemption under Section 4(2) of the Securities Act since the issuance by the Company did not involve a public offering. The issuance was not a public offering as defined in Section 4(2) because the offer and sale was made to an insubstantial number of persons and because of the manner of the offering. In addition, the investors had the necessary investment intent as required by Section 4(2) since they agreed to, and received, certificates bearing a legend stating that such options and underlying shares are restricted. This restriction ensured that these securities will not be immediately redistributed into the market and therefore be part of a public offering. This issuance was done with no general solicitation or advertising by the Company. Based on an analysis of the above factors, the Company met the requirements to qualify for exemption under Section 4(2) of the Securities Act for the transactions.
 
On October 26, 2010 we issued 324,500 shares of common stock to three related parties in consideration of $178,475 of consulting services rendered by a third party. The issuance of the shares of common stock qualified for exemption under Section 4(2) of the Securities Act since the issuance by the Company did not involve a public offering. The issuance was not a public offering as defined in Section 4(2) because the offer and sale was made to an insubstantial number of persons and because of the manner of the offering. In addition, the investors had the necessary investment intent as required by Section 4(2) since they agreed to, and received, share certificates bearing a legend stating that such shares are restricted. This restriction ensured that these shares will not be immediately redistributed into the market and therefore be part of a public offering. This issuance was done with no general solicitation or advertising by the Company. Based on an analysis of the above factors, the Company met the requirements to qualify for exemption under Section 4(2) of the Securities Act for the transactions.
 
In February 2011 we issued options to three individuals for 460,000 shares of common stock exercisable for a period of ten years.  The exercise price of options exercisable for 20,000 shares of common stock was $5.71 per share and the exercise price of options exercisable for 440,000 shares of common stock was $1.10 per share.  The options exercisable for 20,000 shares of common stock vested 50% after one year and 12.5% quarterly thereafter, with all of such options being fully vested February 2013 and the 440,000 options vested immediately subject to forfeiture.   Options exercisable for 220,000 shares of common stock expired. The issuance of the options qualified for exemption under Section 4(2) of the Securities Act since the issuance by the Company did not involve a public offering. The issuance was not a public offering as defined in Section 4(2) because the issuance was made to an insubstantial number of persons and because of the manner of the offering. In addition, the investors had the necessary investment intent as required by Section 4(2) since they agreed to, and received, certificates bearing a legend stating that such options and the underlying shares are restricted. This restriction ensured that these securities will not be immediately redistributed into the market and therefore be part of a public offering. This issuance was done with no general solicitation or advertising by the Company. Based on an analysis of the above factors, the Company met the requirements to qualify for exemption under Section 4(2) of the Securities Act for the transactions.
 
 
In May 2011 we issued options to two individuals for services rendered exercisable for a period of ten years for an aggregate of 12,500 shares of common stock.  The exercise price of both issuances was $5.71 per share.  Of such options, 12,000 vested on a monthly basis of 1,000 options per month  and 500 vested 50% after one year and 12.5% quarterly thereafter, with all of the January 2010 Options being fully vested and the July 2010 Options being fully vested in July 2012. The issuance of the options qualified for exemption under Section 4(2) of the Securities Act since the issuance by the Company did not involve a public offering. The issuance was not a public offering as defined in Section 4(2) because the issuance was made to an insubstantial number of persons and because of the manner of the offering. In addition, the investors had the necessary investment intent as required by Section 4(2) since they agreed to, and received, certificates bearing a legend stating that such options and underlying shares are restricted. This restriction ensured that these securities will not be immediately redistributed into the market and therefore be part of a public offering. This issuance was done with no general solicitation or advertising by the Company. Based on an analysis of the above factors, the Company met the requirements to qualify for exemption under Section 4(2) of the Securities Act for the transactions.

On October 22, 2010, the Company issued 90,000 shares to two existing shareholders in exchange for their judgment and settlement agreement obtained against the third shareholder.  The issuance of the shares of common stock qualified for exemption under Section 4(2) of the Securities Act since the issuance by the Company did not involve a public offering. The issuance was not a public offering as defined in Section 4(2) because the offer and sale was made to an insubstantial number of persons and because of the manner of the offering. In addition, the investors had the necessary investment intent as required by Section 4(2) since they agreed to, and received, share certificates bearing a legend stating that such shares are restricted. This restriction ensured that these shares will not be immediately redistributed into the market and therefore be part of a public offering. This issuance was done with no general solicitation or advertising by the Company. Based on an analysis of the above factors, the Company met the requirements to qualify for exemption under Section 4(2) of the Securities Act for the transactions.

From March 2011 through January 2012, the Company raised $1,947,150 from the sale of securities to 19 investors in a private placement in which it sold units at a price of $5.70 per share for an aggregate of 341,607 shares of series A convertible preferred stock (“Preferred Stock”) and five-year warrants to purchase shares of the Company’s common stock equal to 100% of the number of shares that they would receive upon conversion of the Preferred Stock into common stock.  In connection with the private placement, the Company issued warrants exercisable for an aggregate of 42,800 shares of common stock to two different placement agents. The offering and sale of the shares of the securities qualified for exemption under Section 4(2) of the Securities Act and Regulation D promulgated thereunder since the issuance by the Company did not involve a public offering. The offering was not a public offering as defined in Section 4(2) because the offer and sale was made to an insubstantial number of persons and because of the manner of the offering. In addition, the investors had the necessary investment intent as required by Section 4(2) since they agreed to, and received, certificates bearing a legend stating that such securities are restricted. This restriction ensured that these securities will not be immediately redistributed into the market and therefore be part of a public offering. This offering was done with no general solicitation or advertising by the Company. Based on an analysis of the above factors, the Company met the requirements to qualify for exemption under Section 4(2) of the Securities Act for the transactions.
 
In April 2011 we issued 25,053 shares of Series A Preferred Stock and a warrant exercisable for 25,053 shares of common stock to our Chief Executive Officer in lieu of repayment of loans that he and entities contolled by him had made to the Company. The issuance of the essecurities qualified for exemption under Section 4(2) of the Securities Act and Regulation D promulgated thereunder since the issuance by the Company did not involve a public offering. The issuance was not a public offering as defined in Section 4(2) because the offer and sale was made to an insubstantial number of persons and because of the manner of the offering. In addition, the investor had the necessary investment intent as required by Section 4(2) since the investor agreed to, and received, share certificates and warrant certificates bearing a legend stating that such shares are restricted. This restriction ensured that these securities will not be immediately redistributed into the market and therefore be part of a public offering. This offering was done with no general solicitation or advertising by the Company. Based on an analysis of the above factors, the Company met the requirements to qualify for exemption under Section 4(2) of the Securities Act for the transactions.
 
On October 31, 2011, the Company issued five-year warrants exercisable for 15,000 shares of common stock to a consultant for services performed. The warrants are exercisable at a price of $2.00 per share. The issuance of the warrants qualified for exemption under Section 4(2) of the Securities Act since the issuance by the Company did not involve a public offering. The issuance was not a public offering as defined in Section 4(2) because the offer and sale was made to an insubstantial number of persons and because of the manner of the offering. In addition, the investors had the necessary investment intent as required by Section 4(2) since they agreed to, and received, certificates bearing a legend stating that such warrants and the underlying shares are restricted. This restriction ensured that these securities will not be immediately redistributed into the market and therefore be part of a public offering. This issuance was done with no general solicitation or advertising by the Company. Based on an analysis of the above factors, the Company met the requirements to qualify for exemption under Section 4(2) of the Securities Act for the transactions.

From March 2011 through May 2011 we issued 2,459 shares of common stock to one individual upon exercise of the April 2009 Options, 2,212 shares of common stock to another individual  upon exercise of the October 2009 Options, 1,830 shares of common stock to another individual  upon exercise of the January 2010 Options, 2,418   shares of common stock to another individual  upon exercise of the January 2010 Options and 636 shares of common stock to another individual  upon exercise of the July 2010 Options.  The issuances of common stock were exempt from registration under Section 3(a)(9) of the Securities Act.
 
 
In August and September 2011 we issued options to five individuals for services rendered exercisable for a period of ten years for an aggregate of 5,000 shares of common stock.  The exercise price of both issuances was $5.71 per share.  The options vested 50% after one year and 12.5% quarterly thereafter, with all of the August options being fully vested in August 2013 and all of the September options being fully vested in September 2013. The issuance of the options qualified for exemption under Section 4(2) of the Securities Act since the issuance by the Company did not involve a public offering. The issuance was not a public offering as defined in Section 4(2) because the offer and sale was made to an insubstantial number of persons and because of the manner of the offering. In addition, the investors had the necessary investment intent as required by Section 4(2) since they agreed to, and received, certificates bearing a legend stating that such options and the underlying shares are restricted. This restriction ensured that these securities will not be immediately redistributed into the market and therefore be part of a public offering. This issuance was done with no general solicitation or advertising by the Company. Based on an analysis of the above factors, the Company met the requirements to qualify for exemption under Section 4(2) of the Securities Act for the transactions.
 
In each of December 2011 and February 2012, we issued 50,000 shares of common stock to one entity in consideration of services rendered. The issuance of the shares of common stock qualified for exemption under Section 4(2) of the Securities Act since the issuance by the Company did not involve a public offering. The issuance was not a public offering as defined in Section 4(2) because the offer and sale was made to an insubstantial number of persons and because of the manner of the offering. In addition, the investors had the necessary investment intent as required by Section 4(2) since they agreed to, and received, share certificates bearing a legend stating that such shares are restricted. This restriction ensured that these shares will not be immediately redistributed into the market and therefore be part of a public offering. This issuance was done with no general solicitation or advertising by the Company. Based on an analysis of the above factors, the Company met the requirements to qualify for exemption under Section 4(2) of the Securities Act for the transactions.
 
Item 16.   Exhibits.
 
Exhibit No.
Description
   
3.1
Certificate of Incorporation dated November 12, 2003*
3.2
First Amended and Restated Certificate of Incorporation dated March 8, 2011*
3.3
Certificate of Designations dated March 14, 2011*
3.4
By-Laws *
4.1
Form of Warrant to Purchase Common Stock*
4.2   
Promissory Note, dated September 21, 2006, in the principal amount of $2,200,000 payable to the Incorporated County of Los Alamos*
4.3
Stock Option Plan*
4.4
List of Warrant Holders*
5.1
Opinion of Gracin & Marlow, LLP
10.1
Employment Agreement with Dr. Benjamin Warner*
10.2
Employment Agreement with Lori Peterson (nee Court) *
10.3
Exclusive Patent License Agreement, dated September 8, 2005, by and between the Company and The Regents of the University of California*
10.4
Project Participation Agreement, dated as of September 21, 2006, by and between the Company and the Incorporated County of Los Alamos*
10.5
Amendment No. 1 to Participation Agreement, dated as of February 21, 2007, by and between the Company and the Incorporated County of Los Alamos*
10.6 OEM Agreement, dated July 5, 2011, by and between the Company and Bruker Nano GmbH*
21.1
List of subsidiaries*
23.1
Consent of Registered Public Accounting Firm*
23.2
Consent of Gracin & Marlow, LLP (included in Exhibit 5.1)*

*Filed herewith
**To be filed by amendment
 
 
Item 17.   Undertakings
 
A. Rule 415 Offering
 
The undersigned registrant hereby undertakes:
 
(1)   To file, during any period in which offers or sales are being made, a post-effective amendment to this registration statement:
 
(i) To include any prospectus required by Section 10(a)(3) of the Securities Act of 1933;
 
(ii) To reflect in the prospectus any facts or events arising after the effective date of the registration statement (or the most recent post-effective amendment thereof) which, individually or in the aggregate, represent a fundamental change in the information set forth in the registration statement. Notwithstanding the foregoing, any increase or decrease in volume of securities offered (if the total dollar value of securities offered would not exceed that which was registered) and any deviation from the low or high end of the estimated maximum offering range may be reflected in the form of prospectus filed with the Commission pursuant to Rule 424(b) if, in the aggregate, the changes in volume and price represent no more than  20 percent  change in the maximum aggregate offering price set forth in the “Calculation of Registration Fee” table in the effective registration statement.
 
(iii) To include any material information with respect to the plan of distribution not previously disclosed on the registration statement or any material change to such information in the registration statement;

(2) That, for the purpose of determining any liability under the Securities Act of 1933,  each such post-effective amendment shall be deemed to be  a new registration statement relating to  the securities offered therein, and the offering of such securities at that time shall be deemed to be the initial bona fide offering thereof.
 
(3) To remove from registration by means of a post-effective amendment any of the securities being registered which remain unsold at the termination of the offering.
 
(4) That, for the purpose of determining liability under the Securities Act of 1933 to any purchaser in the initial distribution of the securities:

The undersigned registrant undertakes that in a primary offering of the securities of the undersigned registrant pursuant to this registration statement, regardless of the underwriting method used to sell the securities to the purchaser, if the securities are offered or sold to such purchaser by means of any of the following communications, the undersigned registrant will be a seller and will be considered to offer or sell such securities to such purchaser:
 
(i) Any preliminary prospectus or prospectus of the undersigned registrant relating to the offering required to be filed pursuant to Rule 424 (§230.424 of this chapter);
 
(ii) Any free writing prospectus relating to the offering prepared by or on behalf of the undersigned registrant or used or referred to by the undersigned registrant;
 
(iii) The portion of any other free writing prospectus relating to the offering containing material information about the undersigned registrant or its securities provided by or on behalf of the undersigned registrant; and
 
(iv) Any other communication that is an offer in the offering made by the undersigned registrant to the purchaser.
 
B. Request for Acceleration of Effective Date
 
Insofar as indemnification for liabilities arising under the Securities Act may be permitted to directors, officers and controlling persons of the Company pursuant to the foregoing provisions, or otherwise, the Company has been advised that in the opinion of the Securities and Exchange Commission such indemnification is against public policy as expressed in the Securities Act and is, therefore, unenforceable. In the event that a claim for indemnification against such liabilities (other than the payment by the Company of expenses incurred or paid by a director, officer or controlling person of the Company in the successful defense of any action, suit or proceeding) is asserted by such director, officer or controlling person in connection with the securities being registered, the Company will, unless in the opinion of its counsel the matter has been settled by controlling precedent, submit to a court of appropriate jurisdiction the question whether such indemnification by it is against public policy as expressed in the Securities Act and will be governed by the final adjudication of such issue.


SIGNATURES
 
Pursuant to the requirements of the Securities Act of 1933, the registrant has duly authorized this registration statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the city of Los Alamos, New Mexico, on February 14, 2012.
 
CALDERA PHARMACEUTICALS, INC.
 
     
By: 
/s/ Dr. Benjamin Warner
 
 
Dr. Benjamin Warner, Chief Executive Officer and Director
 

Pursuant to the requirements of the Securities Act of 1933, this registration statement has been signed by the following persons in the capacities and on the dates indicated.
 
Signature
 
Title
 
Date
         
/s/ Dr. Benjamin Warner
 
Chief Executive Officer and Director
 
February 14, 2012
Dr. Benjamin Warner
 
(Principal Executive Officer)
   
         
/s/ Jeremiel Zimmerman
 
Director
 
February 14, 2012
Jeremiel Zimmerman
       
 
/s/ Edward Roffman
 
Director
 
February 14, 2012
Edward Roffman
       

 
 II-6

 
 
Exhibit 3.1
 
CÈRÍTFICATE OF INCORPORATION OF
CALDERA PHARMACEUTICALS, INC.



ARTICLE I

The name of the corporation is Caldera Pharmaceuticals, Inc. (the “Company"),

ARTICLE II

The address of the Company’s registered office in the Stale of Delaware is Corporation Trust Center, 1209 Orange Street, Wilmington, New Castle County, Delaware 19801. The name of its registered agent at such address is The Corporation Trust Company.

ARTICLE III

The purpose of the Company is to engage in any act or activity for which corporations may be organized under the General Corporation Law of Delaware as the same exists or may hereafter be amended.

ARTICLE IV

This Company is authorized to issue one class of shares to be designated Common Stock. The total number of shares of Common Stock the Company has authority to issue is l0,000,000 with par value of $0.001 per share.

ARTICLE V

The name and mailing address of the incorporator are as follows:

David J. McCraigh
2795 East Cottonwood Parkway, Suite 300
Salt Lake City. UT 84121

ARTICLE Vl

In furtherance and not in limitation of the powers conferred by statute, the board of directors of the Company is expressly authorized to make, alter, amend or repeal the bylaws of the Company.

ARTICLE VII

Elections of directors need not be by written ballot unless otherwise provided in the bylaws of the Company.
 
 
 
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ARTICLE VIII

To the fullest extent permitted by the Delaware General Corporation Law, or any other applicable law, as the same exists or may be amended, a director of the Company shall not be personally liable to the Company or its stockholders for monetary damages for any action taken, or any failure to take any action, as a director.

The corporation shall indemnify and hold harmless, to the fullest extent permitted by the Delaware General Corporation Law, or any other applicable law, as the same exists or may hereafter be amended, any director or officer of the Company who was or is made or is threatened to he made a party or is otherwise involved in any action, suit or proceeding, whether civil, criminal, administrative or investigative (a “Proceeding”) by reason of the fact that he or she, or a person for whom he or she is the legal representative,. is or was a director, officer, employee or agent of the Company or is or was serving at the request of the Company as a director, officer, employee or agent of another corporation or of a  joint venture, trust, enterprise or non-profit entity, including service with respect to employee benefit plans, against all liability and loss suffered and expenses reasonably incurred by such person in connection with any such Proceeding. The Company shall be required to indemnify a person in connection with a Proceeding initiated by such person only if the Proceeding was authorized by the Board.

The Company shall have the power to indemnify and hold harmless, to the extent permitted by the Delaware General Corporation Law, or any other applicable law, as the same exists or may hereafter be amended, any employee or agent of the Company who was or is made or is threatened to be made a party or is otherwise involved in any Proceeding by reason of the fact that he or she, or a person for whom he or she is the legal representative, is or was an employee or agent of the Company or is or was serving at the request of the Company as a director, officer, employee or agent of another corporation or of a partnership, joint venture, trust, enterprise or non-profit entity, including service with respect to employee benefit plans, against all liability and loss suffered and expenses reasonably incurred by such person in connection with any such Proceeding.

Neither any amendment nor repeal of this Article, nor the adoption of any provision of this
Certificate of Incorporation inconsistent with this Article, shall eliminate or reduce the effect of this Article in respect of any matter occurring, or any cause of action, suit or claim accruing or arising or that, but for this Article, would accrue or arise, prior to such amendment, repeal or adoption of an inconsistent provision.

ARTICLE VIII

Except as provided in Article VIII above, the Company reserves the right to amend, alter, change or repeal any provision contained in this Certificate of Incorporation, in the manner now or hereafter prescribed by statute, and all rights conferred upon stockholders herein are granted subject to this reservation,
 
 
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I, the undersigned, as the sole incorporator of the Company, have signed this certificate of incorporation on November 12, 2003.



/s/ David J. McCraigh/
___________________________________

David J. McCraigh
Incorporator
 
 
 

Exhibit 3.2
 
FIRST AMENDED AND RESTATED CERTIFICATE OF INCORPORATION
 
OF
 
CALDERA PHARMACEUTICALS, INC.
 

Caldera Pharmaceuticals, Inc., a Delaware corporation (the “Corporation”), hereby certifies:

1.   The name of the Corporation is Caldera Pharmaceuticals, Inc. and the original certificate of incorporation of the Corporation was filed with the Secretary of State for the State of Delaware on November 12, 2003.

2.   This First Amended and Restated Certificate of Incorporation amends and restates the original Certificate of Incorporation, as corrected.

3.   This First Amended and Restated Certificate of Incorporation has been duly adopted by the Corporation’s Board of Directors and stockholders in accordance with Sections 228, 242 and 245 of the Delaware General Corporation Law.

4.   This First Amended and Restated Certificate of Incorporation restates, integrates and further amends the provisions of the Corporation’s certificate of incorporation in its entirety to read as follows:

FIRST : The name of this corporation shall be: CALDERA PHARMACEUTICALS, INC.
 
SECOND : The corporation’s registered office in the State of Delaware is to be located at 1209 Orange Street, Wilmington, County of New Castle, Delaware, 19801. The name of its registered agent at such address is Corporation Trust Company.
 
THIRD : The purpose or purposes of the corporation shall be:
 
To engage in any lawful act or activity for which corporations may be organized under the General Corporation Law of Delaware.
 
FOURTH : The total number of shares of stock which this corporation is authorized to issue is: Fifty million (50,000,000) shares of common stock with $0.001 par value and Ten million (10,000,000) shares of preferred stock with $0.001 par value.

FIFTH : The Board of Directors is authorized, subject to limitations prescribed by law and the provisions of Article Fourth, to provide for the issuance of the shares of preferred stock in series, and by filing a certificate pursuant to the applicable law of the State of Delaware, to establish from time to time the number of shares to be included in each series, and to fix the designations, preferences and relative, participating optional or other special rights, and qualifications, limitations or restrictions thereof.

The authority of the Board of Directors with respect to each series of preferred stock shall include, but not be limited to, determination of the following:

A.  
The number of shares constituting that series and the distinctive designation of that series;

B.  
Whether dividends are to be paid on shares of that series, and if so, the dividend rate, whether dividends shall be cumulative, and if so, from which data or dates, and the relative rights of priority, if any, of payment of dividends on shares of that series;

C.  
Whether that series shall have voting rights, in addition to the voting rights required by law, and if so, the terms of such voting rights;
 
 
 

 
 
D.  
Whether that series shall have conversion privileges, and if so, the terms and conditions of such conversion privileges, including provision for adjustment of the conversion rate in such events as the Board of Directors shall determine;

E.  
Whether the shares of that series shall be redeemable, and if so, the terms and conditions of such redemption, including the date or dates upon or after which they shall be redeemable; the amount per share payable on redemption, which amount may vary under different conditions and at different redemption dates; and whether a sinking fund shall be established for the redemption of shares of that series, and if so, the terms of such sinking fund;

F.  
The rights and preferences of the shares of that series in the event of voluntary or involuntary liquidation, dissolution or winding up of the Corporation, and the relative rights of priority, if any, of payment of shares of that series; and

G.  
Any other relative rights, preferences and limitations of that series.

SIXTH : The Board of Directors shall have the power to adopt, amend or repeal the by-laws.
 
SEVENTH : No director shall be personally liable to the Corporation or its stockholders for monetary damages for any breach of fiduciary duty by such director as a director. Notwithstanding the foregoing sentence, a director shall be liable to the extent provided by applicable law, (i) for breach of the directors duty of loyalty to the Corporation or its stockholders, (ii) for acts or omissions not in good faith or which involve intentional misconduct or a knowing violation of law, (iii) pursuant to Section 174 of the Delaware General Corporation Law or (iv) for any transaction from which the director derived an improper personal benefit. No amendment to or repeal of this Article Seventh shall apply to or have any effect on the liability or alleged liability of any director of the Corporation for or with respect to any acts or omissions of such director occurring prior to such amendment.

IN WITNESS WHEREOF, the Corporation hereby declares that the facts stated herein are true and correct and has caused this certificate to be signed by its duly authorized officer this March 8, 2011.
 
 
  Caldera Pharmaceuticals, Inc.  
       
 
By:
/s/  Benjamin Warner  
  Title: President and Chief Executive Officer  
       
       
                 
           
Exhibit 3.3
CERTIFJCATE OF DESIGNATIONS, PREFERENCES AND RIGHTS
 
OF
 
SERIES A CONVERTIBLE PREFERRED STOCK
 
OF
 
CALDERA PHARMACEUTICALS, INC.
 
CALDERA PHARMACEUTICALS, Inc. (the "Corporation"), a corporation organized and existing under the General Corporation law of the State of Delaware (the "DGCL"), hereby certifies that, pursuant to authority conferred upon the Board of Directors of the Corporation by the Certificate of Incorporation as amended, of the Corporation, and pursuant to Section 151 of the, the Board of Directors of the Corporation has duly adopted the following resolution:
 
RESOLVED, that the Board of Directors, pursuant to authority expressly vested in it by the provisions of the First Amended and Restated Certificate of Incorporation of the Corporation (the "Certificate of Incorporation"'), hereby designates a series of preferred stock as Series A Preferred Stock, par value $0.001 (the "Series A Preferred Stock"), authorizes the Corporation to issue up to Ten Million (10,000,000) shares of Series A Preferred Stock and fixes the relative rights, powers, preferences, limitations, qualifications and restrictions of the Series A Preferred Stock as follows:
 
(1) Dividends. Holders of shares of Series A Preferred Stock shall be entitled to receive a dividend of $0.46 for each share of Series A Preferred Stock on January 1 of each year payable in (i) cash; or (ii) fully paid and non-assessable shares of Common Stock of the Corporation at a price of$5.70 per Common Share, at the option of the Holder. Holders shall be entitled to additional dividends only when, as and if declared by the Board of Directors of the Corporation.
 
(2) Voting Rights. On any matter presented to the stockholders of the Corporation for their action or consideration at any meeting of stockholders of the Corporation (or by written consent of the stockholders in lieu of a meeting), each Holder of outstanding shares of Series A Preferred Stock shall be entitled to cast one vote for each share of Series A Preferred Stock held by such Holder as of the record date for determining stockholders el1titled to vote on such matter. Except as provided by Law or by the other provisions of the Certificate of Incorporation, Holders of Series A Preferred Stock shall vote together with holders of the Common Stock of the Corporation, $0.001 par value (the "Common Stock"), as a single class.
 
(3) Liquidation. Dissolution. Winding-Up.
 
(a) Payments to Holders of Series A Preferred Stock. In the event of any Liquidation Event, the Holders of shares of Series A Preferred Stock then outstanding shall be entitled to be paid out of the assets of the Corporation available for distribution to its stockholders before any payment shall be made to the holders of Common Stock by reason of their ownership thereof, an amount per share equal to the greater of (i) $5.70 per share, plus any dividends declared but unpaid thereon, or (ii) such amount per share as would have been paya.ble had all shares of Series A Preferred Stock been converted into Common Stock pursuant to Section 4 below immediately prior to such Liquidation Event. If upon any such Liquidation Event the assets of the Corporation available for distribution to its stockholders shall be insufficient to pay the Holders of shares of Series A Preferred Stock the full amount to which they shall be entitled under this Section 3(a), the Holders of shares of Series A Preferred Stock shall share ratably in any distribution of the assets available for distribution in proportion to the respective amounts which would otherwise be payable in respect of the shares held by them upon such distribution if all amounts payable on or with respect to such shares were paid in full. "Liquidation Event" means any termination, liquidation, dissolution or winding up of the Corporation. either volW1tary or involuntary.

(b) Payments to Holders of Common Stock. Upon any Liquidation Event, after the payment of all preferential amounts required to be paid to the Holders of shares of Series A Preferred Stock, the remaining assets of the Corporation available for distribution to its stockholders shall be distributed among the holders of shares of Common Stock, pro rata based on the number of shares held by each such holder.
 
(4) Conversion Right.
 
(a) Voluntary Conversion. At any time after the date that a Holder purchases shares of Series A Preferred Stock. such Holder may, at its election, convert each share of Series A Preferred Stock into that number of fully paid and non-assessable shares of Common Stock (or such other equity security of the Corporation for which all of its Common Stock has been exchanged or into which all of its Common Stock has been converted) equal to (i) the Series A Original Purchase Price, divided by (ii) the Conversion Price, subject to adjustments as set forth in this Section 4.
 
(b) Automatic Mandatory Conversion. Ten trading days after delivery to the Holders of written notice of conversion by the Corporation (the "Corporation's Conversion Notice"). each share of Series A Preferred Stock then outstanding shall, by virtue of such conditions and without any action on the part of a Holder thereof, be deemed automatically converted into one fully paid and non-assessable share of Common Stock (or such other equity security of the Corporation for which all or its Common Stock has been exchanged or into which all of its Common Stock has been converted), provided that the volume weighted average closing price of the Corporation's Common Stock over the ten trading days immediately preceding the date of the Corporation's Notice is at least $10.00 per share.
 
 
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(c) Mechanics of Conversion. If a Holder of Series A Preferred Stock desires to convert its Series A Preferred Stock, such Holder shall deliver to the Corporation's Chief Financial Officer written notice expressly to that effect and duly executed by or on behalf of the Holder (a "'Conversion Notice"). The date that the Corporation's Chief Financial Officer actually receives a Conversion Notice shall be deemed to be the conversion date, unless the Holder of Series A Preferred Stock and the Corporation expressly agree to another such date in writing. From and after such conversion date, and assuming rightful and due delivery of a Conversion Notice, the Holder's shares of Series A Preferred Stock shall represent and be enforceable only as the right to receive the shares of Common Stock or other securities issuable in accordance with this Section 4~ Promptly after its receipt of a Conversion Notice, the Corporation shan issue and deliver to such Holder, but only against delivery of and only after receiving the certificates issued to Holder representing the Holder's shares of Series A Preferred Stock, One Or more certificates representing shares of Common Stock issued and registered in the name of such Holder. Thereupon, the Corporation shall have no further obligation to the Holder under or based on the Series A Preferred Stock. Upon any increase or decrease in the number of issued shares of Common Stock resulting from the splitting or consolidation of such shares or the payment of a stock dividend, the number of shares of Common Stock issuable upon conversion of shares of Series A Preferred Stock shall be proportionately adjusted so that the Holder of shares of Series A Preferred Stock surrendered for conversion after the record date of such split, consolidation or dividend shall be entitled to receive the number of shares of Common Stock which such Holder would have been entitled to receive had such Series A Preferred Stock been converted immediately prior to such date.
(5) Redemption Rights
 
(a) Voluntary Redemption. At any time after the date that Corporation receives net cash proceeds of at least three million (S3MM) from litigation proceedings against the Managers of Los Alamos National Laboratory, such Holder may, at its election, redeem each share of Series A Preferred Stock at a price of $7.41 for each share of Series A Preferred Stock.

(b) Involuntary Redemption, Thirty days after delivery to the Holden of written notice of redemption by the Corporation (the "Corporation's Redemption Notice") allowing for Holder to convert each share of Series A Preferred Stock into that number of fully paid and non-assessable shares of Common Stock. each share of Series A Preferred Stock then outstanding shall, by virtue of such conditions and without any action on the part of a Holder herof be redeemed at a price of $7.41 for each share of Series A Preferred Stock.
 
(6) Registration Rights. Not less than twenty one days before Corporation tiles a Registration Statement (the "Corporation's Registration Notice"), whether or not for sale for Corporations own account, on a form and in a manner that would permit registration of Registrable Securities, Corporation shall deliver to Holder written notice of intent to file such Registration Statement. Holder may, at its election, elect to include the underlying shares of Common Stock from Holders shares of Series A Preferred Stock in such Registration Statement.
 
(7) Lost or Stolen Certificates, Upon receipt by the Corporation of evidence reasonably satisfactory to the Corporation of the loss, theft, destruction or mutilation of any certificates representing shares of Series A Preferred Stock, and, in the case of loss, theft or destruction, of an indemnification undertaking by the Holder thereof to the Corporation in customary form and, in the case of mutilation, upon surrender and cancellation of the certificate(s), the Corporation shall execute and deliver new certificate(s) of like tenor and amount.
 
(8) Notice. Any notice required or permitted to be given to a Holder under this Certificate of Designations shall be mailed, postage prepaid, to the post office address last shown on the records of the Corporation, or given by electronic communication in compliance with the provisions of the DGCL, and shall be deemed sent upon such mailing or electronic transmission.
 
(9) Preferred Share Register. The Corporation and/or its transfer agent may treat the Person in whose name any share of Series A Preferred Stock is registered on the register of the Corporation as the owner and holder of such shares of Series A Preferred Stock for all purposes, notwithstanding any notice to the contrary: but in all events recognizing any properly made transfers.

(10) Reservation of Stock Issuable Upon Conversion-The Corporation shall at all times reserve and keep available out of its authorized but unissued shares of Common Stock, solely for the purpose of effecting the conversion of the Series A Preferred Stock, such number: of its shares of Common Stock as shall from time to time be sufficient to effect the conversion of all outstanding shares of Series A Preferred Stock and if at any time the number of authorized but unissued shares of Common Stock shall not be sufficient to effect the conversion of all then outstanding shares of the Series A Preferred Stock, the Corporation will take such corporate action as may, in the opinion of its counsel, be necessary to increase its authorized but unissued shares of Common Stock to such number of shares as shall be sufficient for such purpose, including, without limitation, engaging in best efforts to obtain the requisite stockholder approval of any necessary amendment to this Certificate of Designation.

(11) Fractional Shares. No fractional share shall be issued upon the conversion of any share or shares of Series A Preferred Stock. All shares of Common Stock (including fractions thereof) issuable upon conversion of more than one share of Series A Preferred Stock by a Holder shall be aggregated for purposes of determining whether the conversion would result in the issuance of any fractional share. If, after the aforementioned aggregation, the conversion would result ill the issuance of a fraction of a share of Common Stock l the Corporation shall, in lieu of issuing any fractional share, round such fractional share up to the next whole share of Common Stock and issue such whole share of Common Stock to the Holder upon such conversion.
 
(12) No Other Rights. Shares of Series A Preferred Stock (a) shall not have any rights of preemption as to any securities of the Corporation, or any warrants: rights or options issued or granted with respect thereto, regardless of how such securities, or such warrants, rights or options. may be designated, issued or granted; (b) shall not be redeemable; and (c) shall not have any other rights., preferences, privileges or voting powers or relative, participating, optional or other special rights, or qualifications, limitations or restrictions thereof not set: forth herein or in the Certificate of Incorporation, as amended, or as provided by applicable law.
 
 
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(13) Certain Defined Terms. For purposes of this Certificate of Designations, the following terms shall have the following meanings:


(a) "Certificate of Designations" means this Certificate of Designations, Preferences and Rights of Series A Preferred Stock of CALDERA PHARMACEUTICALS, INC.
 
(b) "Conversion Price" initially means $5.70 per share of Series A Preferred Stock, subject to adjustments set forth in Section 4.
 
(c) "Holder" means any record holder of Series A Preferred Stock as shall appear on the stock register of the Corporation.
 
(e) "Person" means an individual, a limited liability company, a partnership a joint venture, a corporation, a trust. an unincorporated organization and a government or any department or agency thereof.
 
(f) "Securities Purchase Agreement" means that certain Series A Convertible Preferred Stock and Warrant Purchase Agreement by and among the Corporation and for the initial Holders, as such agreement may be amended from time to time as provided in such agreement.

(g) "'Series A Original Issue Date " means the date on which the first share of Series A Preferred Stock was issued to any Holder pursuant to the Securities Purchase Agreement.
 
(h) "Series A Original Purchase Price" means $5.70 per share of Series A Preferred Stock.
 
(i) "Subsidiary" means any Person in which the Corporation, directly or indirectly, has at least a majority ownership interest or majority voting power.

  [REMAINDER OF PAGE INTENTIONALLY LEFT BLANK SIGNATURE PAGE FOLLOWS]
 
 
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IN WITNESS WHEREOF, the Corporation has caused this Certificate of Designations to be duly executed by Ben Warner, its President and Chief Executive Officer, as of the 14 th day of March,2011
 
 
  CALDERA PHARMACEUTICALS, INC.
 
By:   /s/ Benjamin Warner     
Name: Benjamin Warner
Title: President and Chief Executive Officer
 
 
 

Exhibit 3.4
AMENDED AND RESTATED BY-LAWS

OF

CALDERA PHARMACEUTICALS, INC.

 
ARTICLE I

STOCKHOLDERS

 
Section 1.1   Annual Meetings .  An annual meeting of stockholders shall be held for the election of Directors at such date, time and place either within or without the State of Delaware as may be designated by the Board of Direc­tors from time to time.  Any other proper business may be transacted at the annual meeting.
 
Section 1.2   Special Meetings .  Special meetings of stockholders may be called at any time by the Chairman of the Board, if any, the Vice Chairman of the Board, if any, or the President to be held at such date, time and place either within or without the State of Delaware as may be stated in the notice of the meeting.  A special meeting of stockholders shall be called by the Sec­retary upon the written request, stating the purpose of the meeting, of stockholders who together own of record a major­ity of the outstanding shares of each class of stock entitled to vote at such meeting.
 
Section 1.3   Notice of Meetings .  Whenever stock­holders are required or permitted to take any action at a meeting, a written notice of the meeting shall be given which shall state the place, date and hour of the meeting, and, in the case of a special meeting, the purpose or purposes for which the meeting is called.  Unless otherwise provided by law, the written notice of any meeting shall be given not less than ten nor more than sixty days before the date of the meeting to each stockholder entitled to vote at such meeting.  If mailed, such notice shall be deemed to be given when depo­sited in the United States mail, postage prepaid, directed to the stockholder at such stockholder's address as it appears on the records of the Corporation.
 
Section 1.4   Adjournments .  Any meeting of stock­holders, annual or special, may adjourn from time to time to reconvene at the same or some other place, and notice need not be given of any such adjourned meeting if the time and place thereof are announced at the meeting at which the adjournment is taken.  At the adjourned meeting the Cor­poration may transact any business which might have been transacted at the original meeting.  If the adjournment is for more than thirty days, or if after the adjournment a new record date is fixed for the adjourned meeting, a notice of the adjourned meeting shall be given to each stockholder of record entitled to vote at the meeting.
 
Section 1.5   Quorum .  At each meeting of stock­holders, except where otherwise provided by law or the cer­tificate of incorporation or these by-laws, the holders of a majority of the outstanding shares of each class of stock entitled to vote at the meeting, present in person or repre­sented by proxy, shall constitute a quorum.  For purposes of the foregoing, two or more classes or series of stock shall be considered a single class if the holders thereof are enti­tled to vote together as a single class at the meeting.  In the absence of a quorum the stockholders so present may, by majority vote, adjourn the meeting from time to time in the manner provided by Section 1.4 of these by-laws until a quorum shall attend.  Shares of its own capital stock belonging on the record date for the meeting to the Corporation or to another corporation, if a majority of the shares entitled to vote in the election of directors of such other corporation is held, directly or indirectly, by the Corporation, shall neither be entitled to vote nor be counted for quorum pur­poses; provided, however, that the foregoing shall not limit the right of the Corporation to vote stock, including but not limited to its own stock, held by it in a fiduciary capacity.
 
 
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Section 1.6   Organization .  Meetings of stock­holders shall be presided over by the Chairman of the Board, if any, or in the absence of the Chairman of the Board by the Vice Chairman of the Board, if any, or in the absence of the Vice Chairman of the Board by the President, or in the absence of the President by a Vice President, or in the absence of the foregoing persons by a chairman designated by the Board of Directors, or in the absence of such designation by a chairman chosen at the meeting.  The Secretary, or in the absence of the Secretary an Assistant Secretary, shall act as secretary of the meeting, but in the absence of the Secretary and any Assistant Secretary the chairman of the meeting may appoint any person to act as secretary of the meeting.
 
Section 1.7   Voting; Proxies .  Unless otherwise provided in the certificate of incorporation, each stock­holder entitled to vote at any meeting of stockholders shall be entitled to one vote for each share of stock held by such stockholder which has voting power upon the matter in question.  If the certificate of incorporation provides for more or less than one vote for any share on any matter, every reference in these by-laws to a majority or other proportion of stock shall refer to such majority or other proportion of the votes of such stock.  Each stockholder entitled to vote at a meeting of stockholders or to express consent or dissent to corporate action in writing without a meeting may authorize another person or persons to act for such stockholder by proxy, but no such proxy shall be voted or acted upon after three years from its date, unless the proxy provides for a longer period.  A duly executed proxy shall be irrevocable if it states that it is irrevocable and if, and only as long as, it is coupled with an interest suffi­cient in law to support an irrevocable power.  A stockholder may revoke any proxy which is not irrevocable by attending the meeting and voting in person or by filing an instrument in writing revoking the proxy or another duly executed proxy bearing a later date with the Secretary of the Corporation.  Voting at meetings of stockholders need not be by written ballot and need not be conducted by inspectors unless the holders of a majority of the outstanding shares of all classes of stock entitled to vote thereon present in person or by proxy at such meeting shall so determine.  At all meetings of stockholders for the election of directors a plurality of the votes cast shall be sufficient to elect.  With respect to other matters, unless otherwise provided by law or by the certificate of incorporation or these by-laws, the affirmative vote of the holders of a majority of the shares of all classes of stock present in person or represented by proxy at the meeting and entitled to vote on the subject matter shall be the act of the stockholders, provided that (except as other­wise required by law or by the certificate of incorporation) the Board of Directors may require a larger vote upon any such matter.  Where a separate vote by class is required, the affirmative vote of the holders of a majority of the shares of each class present in person or represented by proxy at the meeting shall be the act of such class, except as otherwise provided by law or by the certificate of incorporation or these by-laws.
 
 
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Section 1.8   Fixing Date for Determination of Stockholders of Record .  In order that the Corporation may determine the stockholders entitled to notice of or to vote at any meeting of stockholders or any adjournment thereof, or to express consent to corporate action in writing without a meeting, or entitled to receive payment of any dividend or other distribution or allotment of any rights, or entitled to exercise any rights in respect of any change, conversion or exchange of stock or for the purpose of any other lawful action, the Board of Directors may fix, in advance, a record date, which shall not be more than sixty nor less than ten days before the date of such meeting, nor more than sixty days prior to any other action.  If no record date is fixed: (1) the record date for determining stockholders entitled to notice of or to vote at a meeting of stockholders shall be at the close of business on the day next preceding the day on which notice is given, or, if notice is waived, at the close of business on the day next preceding the day on which the meeting is held; (2) the record date for determining stockholders entitled to express consent to corporate action in writing without a meeting, when no prior action by the Board is necessary, shall be the day on which the first written consent is expressed; and (3) the record date for determining stockholders for any other purpose shall be at the close of business on the day on which the Board adopts the resolution relating thereto.  A determination of stock­holders of record entitled to notice of or to vote at a meet­ing of stockholders shall apply to any adjournment of the meeting; provided, however, that the Board may fix a new record date for the adjourned meeting.
 
Section 1.9   List of Stockholders Entitled to Vote .  The Secretary shall prepare and make, at least ten days before every meeting of stockholders, a complete list of the stock­holders entitled to vote at the meeting, arranged in alpha­betical order, and showing the address of each stockholder and the number of shares registered in the name of each stock­holder.  Such list shall be open to the examination of any stockholder, for any purpose germane to the meeting, during ordinary business hours, for a period of at least ten days prior to the meeting, either at a place within the city where the meeting is to be held, which place shall be specified in the notice of the meeting, or, if not so specified, at the place where the meeting is to be held.  The list shall also be produced and kept at the time and place of the meeting during the whole time thereof and may be inspected by any stockholder who is present.
 
Section 1.10   Consent of Stockholders in Lieu of Meeting .  Any action required by law to be taken at any annual or special meeting of stockholders of the Corporation, or any action which may be taken at any annual or special meeting of such stockholders, may be taken without a meeting, without prior notice and without a vote, if a consent in writing, setting forth the action so taken, shall be signed by the holders of outstanding stock having not less than the minimum number of votes that would be necessary to authorize or take such action at a meeting at which all shares entitled to vote thereon were present and voted.  Prompt notice of the taking of the corporate action without a meeting by less than unanimous written consent shall be given to those stockholders who have not consented in writing.
 
 
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ARTICLE II

BOARD OF DIRECTORS
 
Section 2.1   Powers; Number; Qualifications .  The business and affairs of the Corporation shall be managed by or under the direction of the Board of Directors, except as may be otherwise provided by law or in the certificate of incorporation.  The Board shall consist of one or more members, the number thereof to be determined from time to time by the Board.  Directors need not be stockholders.
 
Section 2.2   Election; Term of Office; Resignation; Removal; Vacancies .  Each director shall hold office until the annual meeting of stockholders next succeeding his or her election and until his or her successor is elected and qualified or until his or her earlier resignation or removal.  Any director may resign at any time upon written notice to the Board of Directors or to the President or the Secretary of the Corporation.  Such resignation shall take effect at the time specified therein, and unless otherwise specified therein no acceptance of such resignation shall be necessary to make it effective.  Any director or the entire Board of Directors may be removed, with or without cause, by the holders of a majority of the shares then entitled to vote at an election of directors; except that, if the certificate of incorporation provides for cumulative voting and less than the entire Board is to be removed, no director may be removed without cause if the votes cast against his or her removal would be sufficient to elect him or her if then cumulatively voted at an election of the entire Board, or, if there be classes of directors, at an election of the class of directors of which he or she is a part.  Whenever the holders of any class or series of stock are entitled to elect one or more directors by the provisions of the certifi­cate of incorporation, the provisions of the preceding sentence shall apply, in respect to the removal without cause of a director or directors so elected, to the vote of the holders of the outstanding shares of that class or series and not to the vote of the outstanding shares as a whole.  Unless otherwise provided in the certificate of incorporation or these by-laws, vacancies and newly created directorships resulting from any increase in the authorized number of directors elected by all of the stockholders having the right to vote as a single class or from any other cause may be filled by a majority of the directors then in office, although less than a quorum, or by the sole remaining director.  Whenever the holders of any class or classes of stock or series thereof are entitled to elect one or more directors by the provisions of the certificate of incorporation, vacancies and newly created directorships of such class or classes or series may be filled by a majority of the directors elected by such class or classes or series thereof then in office, or by the sole remaining director so elected.
 
Section 2.3   Regular Meetings .  Regular meetings of the Board of Directors may be held at such places within or without the State of Delaware and at such times as the Board may from time to time determine, and if so determined notice thereof need not be given.
 
Section 2.4   Special Meetings .  Special meetings of the Board of Directors may be held at any time or place within or without the State of Delaware whenever called by the Chairman of the Board, if any, by the Vice Chairman of the Board, if any, by the President or by any two directors.  Reasonable notice thereof shall be given by the person or persons calling the meeting.
 
 
 
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Section 2.5   Participation in Meetings by Con­ference Telephone Permitted .  Unless otherwise restricted by the certificate of incorporation or these by-laws, members of the Board of Directors, or any committee designated by the Board, may participate in a meeting of the Board or of such committee, as the case may be, by means of conference telephone or similar communications equipment by means of which all persons participating in the meeting can hear each other, and participation in a meeting pursuant to this by-law shall constitute presence in person at such meeting.
 
Section 2.6   Quorum; Vote Required for Action .  At all meetings of the Board of Directors one-third of the entire Board shall constitute a quorum for the transaction of busi­ness.  The vote of a majority of the directors present at a meeting at which a quorum is present shall be the act of the Board unless the certificate of incorporation or these by-laws shall require a vote of a greater number.  In case at any meeting of the Board a quorum shall not be present, the members of the Board present may adjourn the meeting from time to time until a quorum shall attend.
 
Section 2.7   Organization .  Meetings of the Board of Directors shall be presided over by the Chairman of the Board, if any, or in the absence of the Chairman of the Board by the Vice Chairman of the Board, if any, or in the absence of the Vice Chairman of the Board by the President, or in their absence by a chairman chosen at the meeting.  The Secretary, or in the absence of the Secretary an Assistant Secretary, shall act as secretary of the meeting, but in the absence of the Secretary and any Assistant Secretary the chairman of the meeting may appoint any person to act as secretary of the meeting.
 
Section 2.8   Action by Directors Without a Meeting .  Any action required or permitted to be taken at any meeting of the Board of Directors, or of any committee thereof, may be taken without a meeting if all members of the Board or of such committee, as the case may be, consent thereto in writing, and the writing or writings are filed with the minutes of proceedings of the Board or committee.
 
Section 2.9   Compensation of Directors .  The Board of Directors shall have the authority to fix the compensation of directors.
 
ARTICLE III

COMMITTEES
 
Section 3.1   Committees .  The Board of Directors may, by resolution passed by a majority of the whole Board, designate one or more committees, each committee to consist of one or more of the directors of the Corporation.  The Board may designate one or more directors as alternate members of any committee, who may replace any absent or disqualified member at any meeting of the committee.  In the absence or disqualification of a member of a committee, the member or members thereof present at any meeting and not disqualified from voting, whether or not such member or members constitute a quorum, may unanimously appoint another member of the Board to act at the meeting in place of any such absent or disqualified member.  Any such committee, to the extent provided in the resolution of the Board, shall have and may exercise all the powers and authority of the Board in the management of the business and affairs of the Corporation, and may authorize the seal of the Corporation to be affixed to all papers which may require it; but no such committee shall have power or authority in reference to amending the certificate of incorporation, adopting an agreement of merger or consolidation, recommending to the stockholders the sale, lease or exchange of all or substantially all of the Corporation's property and assets, recommending to the stockholders a dissolution of the Corporation or a revoca­tion of dissolution, removing or indemnifying directors or amending these by-laws; and, unless the resolution expressly so provides, no such committee shall have the power or authority to declare a dividend or to authorize the issuance of stock.
 
 
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Section 3.2   Committee Rules .  Unless the Board of Directors otherwise provides, each committee designated by the Board may adopt, amend and repeal rules for the conduct of its business.  In the absence of a provision by the Board or a provision in the rules of such committee to the contrary, a majority of the entire authorized number of members of such committee shall constitute a quorum for the transaction of business, the vote of a majority of the members present at a meeting at the time of such vote if a quorum is then present shall be the act of such committee, and in other respects each committee shall conduct its business in the same manner as the Board conducts its business pursuant to Article II of these by-laws.
 
ARTICLE IV

OFFICERS
 
Section 4.1   Officers; Election .  As soon as practicable after the annual meeting of stockholders in each year, the Board of Directors shall elect a President and a Secretary, and it may, if it so determines, elect from among its members a Chairman of the Board and a Vice Chairman of the Board.  The Board may also elect one or more Vice Presidents, one or more Assistant Vice Presidents, one or more Assistant Secretaries, a Treasurer and one or more Assistant Treasurers and such other officers as the Board may deem desirable or appropriate and may give any of them such further designations or alternate titles as it con­siders desirable.  Any number of offices may be held by the same person.
 
Section 4.2   Term of Office; Resignation; Removal; Vacancies .  Except as otherwise provided in the resolution of the Board of Directors electing any officer, each officer shall hold office until the first meeting of the Board after the annual meeting of stockholders next succeeding his or her election, and until his or her suc­cessor is elected and qualified or until his or her earlier resignation or removal.  Any officer may resign at any time upon written notice to the Board or to the President or the Secretary of the Corporation.  Such resignation shall take effect at the time specified therein, and unless otherwise specified therein no acceptance of such resignation shall be necessary to make it effective.  The Board may remove any officer with or without cause at any time.  Any such removal shall be without prejudice to the contractual rights of such officer, if any, with the Corporation, but the election of an officer shall not of itself create contractual rights.  Any vacancy occurring in any office of the Corporation by death, resignation, removal or otherwise may be filled for the unexpired portion of the term by the Board at any regular or special meeting.
 
 
 
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Section 4.3   Chairman of the Board .  The Chairman of the Board, if any, shall preside at all meetings of the Board of Directors and of the stockholders at which he or she shall be present and shall have and may exercise such powers as may, from time to time, be assigned to him or her by the Board and as may be provided by law.
 
Section 4.4   Vice Chairman of the Board .  In the absence of the Chairman of the Board, the Vice Chairman of the Board, if any, shall preside at all meetings of the Board of Directors and of the stockholders at which he or she shall be present and shall have and may exercise such powers as may, from time to time, be assigned to him or her by the Board and as may be provided by law.
 
Section 4.5   President .  In the absence of the Chairman of the Board and Vice Chairman of the Board, the President shall preside at all meetings of the Board of Directors and of the stockholders at which he or she shall be present.  The President shall be the chief executive officer and shall have general charge and supervision of the business of the Corporation and, in general, shall perform all duties incident to the office of president of a corporation and such other duties as may, from time to time, be assigned to him or her by the Board or as may be provided by law.
 
Section 4.6   Vice Presidents .  The Vice President or Vice Presidents, at the request or in the absence of the President or during the President's inability to act, shall perform the duties of the President, and when so acting shall have the powers of the President.  If there be more than one Vice President, the Board of Directors may deter­mine which one or more of the Vice Presidents shall perform any of such duties; or if such determination is not made by the Board, the President may make such determination; otherwise any of the Vice Presidents may perform any of such duties.  The Vice President or Vice Presidents shall have such other powers and shall perform such other duties as may, from time to time, be assigned to him or her or them by the Board or the President or as may be provided by law.
 
Section 4.7   Secretary .  The Secretary shall have the duty to record the proceedings of the meetings of the stockholders, the Board of Directors and any committees in a book to be kept for that purpose, shall see that all notices are duly given in accordance with the provisions of these by-laws or as required by law, shall be custodian of the records of the Corporation, may affix the corporate seal to any document the execution of which, on behalf of the Corporation, is duly authorized, and when so affixed may attest the same, and, in general, shall perform all duties incident to the office of secretary of a corporation and such other duties as may, from time to time, be assigned to him or her by the Board or the President or as may be provided by law.
 
Section 4.8   Treasurer .  The Treasurer shall have charge of and be responsible for all funds, securities, receipts and disbursements of the Corporation and shall deposit or cause to be deposited, in the name of the Cor­poration, all moneys or other valuable effects in such banks, trust companies or other depositories as shall, from time to time, be selected by or under authority of the Board of Directors.  If required by the Board, the Treasurer shall give a bond for the faithful discharge of his or her duties, with such surety or sureties as the Board may determine.  The Treasurer shall keep or cause to be kept full and accurate records of all receipts and disbursements in books of the Corporation, shall render to the President and to the Board, whenever requested, an account of the financial condition of the Corporation, and, in general, shall perform all the duties incident to the office of treasurer of a corporation and such other duties as may, from time to time, be assigned to him or her by the Board or the President or as may be provided by law.
 
 
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Section 4.9   Other Officers .  The other officers, if any, of the Corporation shall have such powers and duties in the management of the Corporation as shall be stated in a resolution of the Board of Directors which is not inconsistent with these by-laws and, to the extent not so stated, as generally pertain to their respective offices, subject to the control of the Board.  The Board may require any officer, agent or employee to give security for the faithful performance of his or her duties.
 
ARTICLE V

STOCK
 
Section 5.1   Certificates .  Every holder of stock in the Corporation shall be entitled to have a certificate signed by or in the name of the Corporation by the Chairman or Vice Chairman of the Board of Directors, if any, or the President or a Vice President, and by the Treasurer or an Assistant Treasurer, or the Secretary or an Assistant Secre­tary, of the Corporation, certifying the number of shares owned by such holder in the Corporation.  If such certificate is manually signed by one officer or manually countersigned by a transfer agent or by a registrar, any other signature on the certificate may be a facsimile.  In case any officer, transfer agent or registrar who has signed or whose facsimile signature has been placed upon a certificate shall have ceased to be such officer, transfer agent or registrar before such certificate is issued, it may be issued by the Corpora­tion with the same effect as if such person were such officer, transfer agent or registrar at the date of issue.
 
Section 5.2   Lost, Stolen or Destroyed Stock Certificates; Issuance of New Certificates .  The Corporation may issue a new certificate of stock in the place of any cer­tificate theretofore issued by it, alleged to have been lost, stolen or destroyed, and the Corporation may require the owner of the lost, stolen or destroyed certificate, or such owner's legal representative, to give the Corporation a bond suffi­cient to indemnify it against any claim that may be made against it on account of the alleged loss, theft or destruc­tion of any such certificate or the issuance of such new certificate.
 
ARTICLE VI

MISCELLANEOUS

 
Section 6.1   Fiscal Year .  The fiscal year of the Corporation shall be determined by the Board of Directors.
 
Section 6.2   Seal .  The Corporation may have a corporate seal which shall have the name of the Corporation inscribed thereon and shall be in such form as may be approved from time to time by the Board of Directors.  The corporate seal may be used by causing it or a facsimile thereof to be impressed or affixed or in any other manner reproduced.
 
 
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Section 6.3   Waiver of Notice of Meetings of Stockholders, Directors and Committees .  Whenever notice is required to be given by law or under any provision of the cer­tificate of incorporation or these by-laws, a written waiver thereof, signed by the person entitled to notice, whether before or after the time stated therein, shall be deemed equiv­alent to notice.  Attendance of a person at a meeting shall constitute a waiver of notice of such meeting, except when the person attends a meeting for the express purpose of objecting, at the beginning of the meeting, to the transaction of any business because the meeting is not lawfully called or con­vened.  Neither the business to be transacted at, nor the purpose of, any regular or special meeting of the stockholders, directors, or members of a committee of directors need be specified in any written waiver of notice unless so required by the certificate of incorporation or these by-laws.
 
Section 6.4   Indemnification of Directors, Officers and Employees .  The Corporation shall indemnify to the full extent authorized by law any person made or threatened to be made a party to any action, suit or proceeding, whether criminal, civil, administrative or investigative, by reason of the fact that such person or such person's testator or intestate is or was a director, officer or employee of the Corporation or serves or served at the request of the Corporation any other enterprise as a director, officer or employee.  For purposes of this by-law, the term “Corporation” shall include any predecessor of the Corporation and any constituent corporation (including any constituent of a constituent) absorbed by the Corporation in a consolidation or merger; the term "other enterprise" shall include any corporation, partnership, joint venture, trust or employee benefit plan; service "at the request of the Corporation" shall include service as a director, officer or employee of the Corporation which imposes duties on, or involves ser­vices by, such director, officer or employee with respect to an employee benefit plan, its participants or beneficiaries; any excise taxes assessed on a person with respect to an employee benefit plan shall be deemed to be indemnifiable expenses; and action by a person with respect to an employee benefit plan which such person reasonably believes to be in the interest of the participants and beneficiaries of such plan shall be deemed to be action not opposed to the best interests of the Corporation.
 
Section 6.5   Interested Directors or Officers; Quorum .  No contract or transaction between the Corporation and one or more of its directors or officers, or between the Corporation and any other corporation, partnership, association or other organization in which one or more of its directors or officers are directors or officers, or have a financial interest, shall be void or voidable solely for this reason, or solely because the director or officer is present at or participates in the meeting of the Board of Directors or committee thereof which authorizes the contract or trans­action, or solely because his or her or their votes are counted for such purpose, if: (1) the material facts as to his or her relationship or interest and as to the contract or transaction are disclosed or are known to the Board or the committee, and the Board or committee in good faith authorizes the contract or transaction by the affirmative votes of a majority of the disinterested directors, even though the disinterested directors be less than a quorum; or (2) the material facts as to his or her relationship or interest and as to the contract or transaction are disclosed or are known to the stockholders entitled to vote thereon, and the contract or transaction is specifically approved in good faith by vote of the stockholders; or (3) the contract or transaction is fair as to the Corporation as of the time it is authorized, approved or ratified, by the Board, a committee thereof or the stockholders.  Common or interested directors may be counted in determining the presence of a quorum at a meeting of the Board or of a committee which authorizes the contract or transaction.
 
 
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Section 6.6   Form of Records .  Any records main­tained by the Corporation in the regular course of its busi­ness, including its stock ledger, books of account and minute books, may be kept on, or be in the form of, punch cards, magnetic tape, photographs, microphotographs or any other information storage device, provided that the records so kept  can be converted into clearly legible form within a reasonable time.  The Corporation shall so convert any records so kept upon the request of any person entitled to inspect the same.
 
Section 6.7   Amendment of By-Laws .  These by-laws may be amended or repealed, and new by-laws adopted, by the Board of Directors, but the stockholders entitled to vote may adopt additional by-laws and may amend or repeal any by-law whether or not adopted by them.
 
 
 
 
 
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Exhibit 4.1
 
THIS WARRANT AND THE SECURITIES ISSUABLE UPON EXERCISE OF THIS WARRANT HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “ACT”) OR UNDER ANY STATE SECURITIES LAWS.  THIS WARRANT AND THE COMMON STOCK ISSUABLE UPON EXERCISE OF THIS WARRANT MAY NOT BE OFFERED, SOLD, OR OTHERWISE TRANSFERRED IN THE ABSENCE OF AN EFFECTIVE REGISTRATION STATEMENT FOR THE SECURITIES UNDER APPLICABLE SECURITIES LAWS OR UNLESS OFFERED, SOLD OR TRANSFERRED PURSUANT TO AN AVAILABLE EXEMPTION FROM THE REGISTRATION REQUIREMENTS OF THOSE LAWS.  THE SECURITIES REPRESENTED BY THIS CERTIFICATE ARE ALSO SUBJECT TO RESTRICTIONS ON TRANSFER PURSUANT TO AN AGREEMENT BETWEEN THE HOLDER AND THE CORPORATION, A COPY OF WHICH MAY BE OBTAINED FROM THE CORPORATION.
 
WARRANT TO PURCHASE COMMON STOCK
OF
CALDERA PHARMACEUTICALS, INC.
 
Date of Issuance:  __________, 2011                                                                                     Number of Warrant: WC- _____
 
THIS WARRANT (“ Warrant ”) certifies that, for value received,  _____________, a/an individual or corporation, or its permitted assigns registered on the books (collectively, the “ Holder ”) of Caldera Pharmaceuticals, Inc., a Delaware corporation (the “ Company ”), having its principal place of business at 278 DP Road Suite D, Los Alamos, NM 87544, is entitled to purchase at any time during the Exercise Period (as defined below), _____________ whole shares (the “ Warrant Shares ”) of the Company’s common stock, par value $0.001 per share (the “ Common Stock ”) at an exercise price per share equal to $5.70  (the “ Exercise Price ”).
 
This Warrant is issued pursuant to, and is subject to the terms and conditions of a Series A Convertible Preferred Stock and Warrant Purchase Agreement (the “ Purchase Agreement ”) dated ____________ between the Company and Holder, a copy of which is attached hereto as Exhibit A .  Capitalized terms not defined herein shall have the meanings set forth in the Purchase Agreement.
 
1.   Exercise .
 
1.1   Manner of Exercise . Pursuant to the terms and conditions set forth in this Warrant, the Holder may exercise this Warrant at any time during the Exercise Period, at the option of the Holder, upon surrender of this Warrant to the Company together with a duly completed Notice of Exercise, in the form attached hereto as Exhibit B , and payment of an amount equal to the Exercise Price multiplied by the number of Warrant Shares to be exercised.  Subject to Section 1.2, in the case of exercise of less than all the Warrant Shares represented by this Warrant, the Company shall cancel this Warrant upon the surrender thereof and shall execute and deliver a new warrant for the balance of such Warrant Shares.
 
 
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1.2   Effective Time of Exercise .  Each exercise of this Warrant shall be deemed to have been effected immediately prior to the close of business on the day on which this Warrant shall have been surrendered to the Company as provided in Section 1.1 above.  At such time, the person or persons in whose name or names any certificates for Warrant Shares shall be issuable upon such exercise as provided in Section 1.4 below shall be deemed to have become the holder or holders of record of the Warrant Shares for which this Warrant has been exercised.
 
1.3   Delivery to Holder .  As soon as practicable after the exercise of this Warrant in whole or in part, and in any event within twenty days thereafter, the Company will cause to be issued in the name of, and delivered to, the Holder, or as such Holder (upon payment by such Holder of any applicable transfer taxes) may direct:
 
1.4   a certificate or certificates for the Warrant Shares to which such Holder shall be entitled, and
 
1.5   in case such exercise is in part only, a new warrant or warrants (dated the date hereof) of like tenor, calling in the aggregate on the face or faces thereof for the number of shares of Warrant Shares equal (without giving effect to any adjustment therein) to the number of such shares called for on the face of this Warrant minus the number of such shares purchased by the Holder upon such exercise.
 
2.   Exercise Period .  The “ Exercise Period ” means a period beginning on the date of issuance and ending on the fifth anniversary thereof, or if such ending date shall be a holiday or a day on which banks are authorized to close, then the next following date which is not a holiday or a day on which banks are not authorized to close (the “ Termination Date ”).  If the Holder does not exercise this Warrant with respect to all Warrant Shares during the Exercise Period, if any, this Warrant will automatically expire on the Termination Date.
3.   Agreement of Holder .  The Holder acknowledges that this Warrant and the Warrant Shares represented by this Warrant have not been registered under the Securities Act of 1933, as amended (the “ Securities Act ”) or any applicable state securities laws and accordingly that they will not be transferred or sold except pursuant to (i) an effective registration statement or qualification under the Securities Act or any applicable state securities law, or (ii) an opinion of counsel, satisfactory to the Company and Company’s counsel, that such registration and qualification are not required.
 
4.   Loss or Mutilation .  Upon receipt by the Company of reasonable evidence of the ownership of and the loss, theft, destruction or mutilation of this Warrant and, in the case of loss, theft or destruction, of indemnity reasonably satisfactory to the Company, or, in the case of mutilation, upon surrender and cancellation of the mutilated Warrant, the Company shall execute and deliver in lieu thereof a new warrant representing an equal number of Warrant Shares.
 
 
 
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5.   Adjustment of Exercise Price and Number of Warrant Shares .  The number and kind of Warrant Shares purchasable upon the exercise of this Warrant and the Exercise Price shall be subject to adjustment from time to time upon the occurrence of certain events, as follows:
 
5.1   Splits, Combinations, Reclassifications .  If, during the Exercise Period, the Company (i) subdivides its outstanding shares of Warrant Shares through stock split or otherwise, or (ii) combines its outstanding shares of Warrant Shares into a smaller number of shares of Warrant Shares, then the number and/or nature of Warrant Shares purchasable upon exercise of this Warrant immediately prior thereto shall be adjusted so that the Holder shall be entitled to receive the kind and number of Warrant Shares or other securities of the Company which Holder would have owned or have been entitled to receive after the happening of any of the events described above, had this Warrant been exercised immediately prior to the effective date of such event or any record date with respect thereto.  Upon each adjustment in the number of Warrant Shares purchasable hereunder pursuant to this Section 5.1, the Exercise Price shall be proportionately increased or decreased, as the case may be, in a manner that is the inverse of the manner in which the number of Warrant Shares purchasable hereunder shall be adjusted, as determined in good faith by the Board of Directors of the Company.
 
5.2   Notice of Capital Changes .  If at any time the Company shall effect any of the events described in Section 5.1 or any Additional Issuances described in Section 5.2 above, or there shall be a voluntary or involuntary dissolution, liquidation or winding up of the Company, then, in any one or more of said cases, the Company shall give the Holder written notice, by registered or certified mail, postage prepaid, of the date on which (i) a record shall be taken for such dividends, distributions and the like, (ii) the Additional Issuances shall close, or (ii) such reorganization, reclassification, consolidation, merger, sale, dissolution, liquidation or winding up shall take place, as the case may be.  Such written notice shall be given at least ten days prior to the relevant event.
 
5.3   Certificates of Adjustments .  Whenever the Exercise Price or the number of Warrant Shares purchasable hereunder shall be adjusted pursuant to this Section 5, the Company shall prepare a certificate signed by the Chief Financial Officer of the Company setting forth, in reasonable detail, the event requiring the adjustment, the amount of the adjustment, the method by which such adjustment was calculated, and the Exercise Price and the number of Warrant Shares purchasable hereunder after giving effect to such adjustment, and shall cause copies of such certificate to be mailed, by first class mail, postage prepaid, to the Holder.
 
6.   No Rights as Shareholder .  Until the exercise of this Warrant, the Holder of this Warrant shall not have or exercise any rights by virtue hereof as a shareholder of the Company.  This Warrant shall not be deemed to confer upon the Holder any right to vote or to consent to or receive notice as a shareholder of the Company, in respect of any matters whatsoever, prior to the exercise hereof.
 
 
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7.   Transfers .
 
7.1   Unregistered Security .  Each holder of this Warrant acknowledges that this Warrant and the Warrant Shares of the Company have not been registered under the Securities Act or any applicable state securities law, and agrees not to sell, pledge, distribute, offer for sale, transfer or otherwise dispose of this Warrant or any Warrant Shares issued upon its exercise in the absence of (i) an effective registration statement under the Securities Act as to this Warrant or such Warrant Shares and registration or qualification of this Warrant or such Warrant Shares under any applicable U.S. federal or state securities law then in effect, or (ii) an opinion of counsel, satisfactory to the Company, that such registration and qualification are not required.  Each certificate or other instrument for Warrant Shares issued upon the exercise of this Warrant shall bear a legend substantially to the foregoing effect.  The foregoing notwithstanding, Holder may transfer this Warrant for bona fide estate planning purposes in which no consideration is paid for such transfer, either during Holder’s lifetime or on death, by will or intestacy, to Holder’s spouse, children, parents, or siblings, or any custodian or trustee of any trust, partnership or limited liability company for the benefit of, or the ownership interests of which are wholly owned by, Holder or any such family members, provided that Holder shall deliver prior written notice to the Company of any such transfer and this Warrant shall at all times remain subject to the terms and restrictions set forth in this Agreement and each transferee, shall, as a condition to such transfer, deliver a counterpart signature page to the Purchase Agreement as confirmation that such transferee shall be bound by all the terms and conditions thereof.
 
7.2   Transferability .  Subject to the provision of Section 7.1 hereof, this Warrant and all rights hereunder are transferable, in whole or in part, only upon surrender of this Warrant with a properly executed assignment (in the form of Exhibit C hereto) at the principal office of the Company.
 
7.3   Warrant Register .  The Company will maintain a register containing the names and addresses of the Holders of this Warrant.  Until any transfer of this Warrant is made in the warrant register, the Company may treat the Holder of this Warrant as the absolute owner hereof for all purposes; provided, however , that if this Warrant is properly assigned in blank, the Company may (but shall not be required to) treat the bearer hereof as the absolute owner hereof for all purposes, notwithstanding any notice to the contrary.  Any Holder may change such Holder’s address as shown on the warrant register by written notice to the Company requesting such change.
 
8.   Fractional Shares .  Notwithstanding that the number of Warrant Shares purchasable upon the exercise of this Warrant may have been adjusted pursuant to the terms hereof, the Company shall nonetheless not be required to issue fractions of shares upon the exercise of the Warrants or to distribute certificates that evidence fractional shares nor shall the Company be required to make any cash payments in lieu thereof upon exercise of the Warrants.  Holder hereby waives any right to receive fractional shares.
 
 
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9.   Notices .  Except as otherwise expressly provided herein, all notices and other communications required or permitted hereunder shall be effective upon receipt and shall be in writing and may be delivered in person, by telecopy, overnight delivery service or United States mail, in which event it may be mailed by first-class, certified or registered, postage prepaid, addressed (i) if to a Holder, to the address appearing on the books of the Company, or at such other address as the Holder shall have furnished to the Company in writing, or (ii) if to the Company, at 278 DP Road Suite D, Los Alamos, NM 87544, attention: Chief Financial Officer; or at such other address as the Company shall have furnished to the Investor in writing.
 
10.   Successors and Assigns .  This Warrant shall be binding on and inure to the benefit of the heirs, executors, administrators, successors, and assigns of the respective parties.
 
11.   Amendment or Waiver .  Any term of this Warrant may be amended or waived only by an instrument in writing signed by the Company and the Holders of at least a majority in interest of the then-outstanding Warrants. Any amendment or waiver affected in accordance with this Section 11 shall be binding upon the Company, the Holders of the Warrants and each transferee of a Warrant.
 
12.   Governing Law .  This Warrant shall be governed by and construed in accordance with the laws of the State of Delaware, without regard to the conflicts of law provisions of the State of Delaware or of any other state.
 
13.   Severability .  If any provision of the Warrant is determined to be invalid, illegal or unenforceable, in whole or in part, the validity, legality and enforceability of any of the remaining provisions or portions of the Warrant shall not in any way be affected or impaired thereby and the Warrant shall nevertheless be binding between the Company and the Holder.
 
14.   Headings . The descriptive headings in the Warrant are inserted for convenience only and do not constitute a part of the Warrant.
 
15.   Entire Agreement .  This Warrant and the Purchase Agreement constitute the full and complete agreement of the parties with respect to the subject matter hereof, and supersede any prior agreements between the parties with respect thereto.
 
[Signature on following page]
 
 
 
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IN WITNESS WHEREOF, this Warrant has been executed as of ________________, 2009.
 
 
  CALDERA PHARMACEUTICALS, INC.
a Delaware corporation
 
 
By:           __________________________
Name:      __________________________
Title:         __________________________
 
 
 
 
 

 
 
EXHIBIT A
 
SERIES A CONVERTIBLE PREFERRED STOCK AND WARRANT PURCHASE AGREEMENT
 
 
 
 
 
 
 
 

 
 
 
EXHIBIT B
 
NOTICE OF EXERCISE
 
 
 
To:  Caldera Pharmaceuticals, Inc.
 
The undersigned, pursuant to the provisions set forth in the attached Warrant No. _____, hereby irrevocably elects to purchase _______ shares of Common Stock of the Company covered by such Warrant and herewith makes payment of $_________, representing the full purchase price for such shares at the price per share provided for in such Warrant.
 
 
Date: ____________________
  ____________________________
Name of Holder
 
____________________________
Signature
 
____________________________
Address
____________________________
 
____________________________
 
 
 
 
 
 

 
 
 
EXHIBIT C
 
ASSIGNMENT FORM
 
FOR VALUE RECEIVED, _________________________________________ hereby sells, assigns and transfers all of the rights of the undersigned under the attached Warrant with respect to the number of shares of Common Stock of the Company covered thereby set forth below, unto:
 
Name of Assignee:                               __________________________
Address of Assignee:                          __________________________
 __________________________
Facsimile Number:                                 __________________________
No. of Shares:                                        __________________________
 
 
 
 

Exhibit 4.2
 
SECURED PROMISSORY NOTE
 
$2,200,000.00  Los Alamos, New Mexico
  September 21, 2006
 
For value received, Caldera Pharmaceuticals Inc., a Delaware corporation qualified to do business in New Mexico, ("Borrower"), promises to pay to the order of the Incorporated County of Los Alamos, an incorporated County of the State of New Mexico, (the "County"), with memo reference to "Caldera Pharmaceuticals Loan No. 1" at the County's offices located at: Los Alamos County; Attention: Finance Department; Post Office Box 30; 2300 Trinity Drive; Los Alamos, New Mexico 87544, or at such other place as the County may hereafter designate in writing, the principal amount not to exceed Two Million Two Hundred Thousand Dollars ($2,200,000) (the "Loan Amount"), or so much thereof as may from time to time be owing hereunder by reason of advance by the County to or for the benefit or account of Borrower under the terms of the Loan Agreement (the "Loan Agreement") or the Participation Agreement (the "Participation Agreement") both between Borrower and the County executed of even date herewith.

The County shall disburse the loan proceeds as Borrower may request in amounts consistent with Loan Agreement, the Participation Agreement, and Los Alamos County Ordinance No. 512, and such disbursements shall commence on or after the effective date of this Promissory Note and shall continue in no event later than the close of business on September 21, 2008 in an aggregate amount not to exceed the Loan Amount. If, at close of business on September 21, 2008 the County has not disbursed the entire Loan Amount, the County will prepare a new Amortization Schedule reflecting the amount of the loan proceeds actually disbursed and Borrower shall be required to repay the principal amount of the loan actually disbursed at the interest rate provided herein and in such amounts as the new Amortization Schedule shall provide. Any new Amortization Schedule prepared pursuant to the requirements of this provision shall become a part of the Loan Agreement replacing Attachment A thereto and incorporated by reference as if fully set forth therein.

This Promissory Note bears interest at five percent (5%) per annum and shall be amortized over a ten year term with one hundred twenty (120) equal monthly installments of TWENTY FOUR THOUSAND SEVEN HUNDRED NINETY-TWO DOLLARS AND EIGHTY-ONE CENTS ($24,792.81) due beginning September 21, 2009 and the first of each month thereafter until paid in full. All past due installments of principal and interest, including the unpaid balance of principal and interest during the existence of any default and maturity of the Promissory Note shall bear interest at the rate of the prime rate plus two percent (2%). This Promissory Note may be prepaid in whole or in part at any time without premium or penalty.

No partial prepayment shall affect the obligation of Borrower to pay the regular installments due hereunder until this Promissory Note has been paid in full. The outstanding principal balance of this Promissory Note, together with all accrued and unpaid interest, shall be due and payable in full no later than September 21, 2019.

This Promissory Note shall be secured by, among other things, all building and including any and all equipment, furnishings, computing and telecommunications infrastructure, or other items of tangible, personal property, furnished or purchased in whole or in part by the proceeds of the Loan Agreement; The security described in shall remain in Los Alamos County. Default, as used herein, shall mean the occurrence of any one or more of the following events:

(a) Failure by the Borrower to pay principal of or interest on this Promissory Note when due.

(b) Failure of Borrower to punctually and properly perform, observe or comply with any covenant, agreement, undertaking, or condition contained in this Promissory Note, or any renewal, modification, rearrangement, amendment, or extension thereof or in the Loan Agreement or Participation Agreement.

(c)  Relocation by the Borrower of its research, design, and development activities outside of or otherwise ceasing its operations in Los Alamos County.
 
 
 

 
 
(d) The filing of a petition, case, proceeding, or other action against Borrower as a debtor under any debtor relief law or seeking appointment of a receiver, trustee, custodian, or liquidator of Borrower or of any property financed or purchased in whole or in part from the proceeds of this Promissory Note, or seeking to effect a suspension or having the effect of suspending any of the rights of the County granted or referred to in this Promissory Note or the loan documents relating thereto and (i) Borrower admits, acquiesces in, or fails to contest diligently the material allegations thereof; (ii) the petition, case, proceeding, or other action results in entry of an order for relief or order granting relief sought against Borrower; or (iii) the petition, case, proceeding, or other action not permanently dismissed or discharged on or before ninety (90) days» following the dam of its filing.

(e) The abandonment by Borrower of all or any portion of the property financed in whole or in part by the proceeds of this Promissory Note or the abandonment by Borrower of its leased premises in Los Alamos County.

(f) The discovery by the County that any representation, warranty or covenant made by Borrower in connection with the indebtedness evidenced by this Promissory Note or in the Loan Agreement or Participation Agreement or in any loan document relating thereto in connection with the obligations secured hereby is or becomes false, misleading, erroneous, or breached in any material respect.

(g) Any default under the Loan Agreement or Participation Agreement shall be a default under this Promissory Note.

Upon any default by Borrower in its obligations under this Promissory Note, the Loan Agreement, or the Participation Agreement, the County at its option may declare all or any part of the indebtedness evidenced by this Promissory Note to be immediately due and payable. Default determination and resolution will be as provided in this Promissory Note, the Loan Agreement, and the Participation Agreement.

If this Promissory Note or any instrument securing or collateral to it is given to an attorney for collection or enforcement, or if suit is brought for collection or enforcement, or if it is collected or enforced through probate, bankruptcy, or other judicial proceeding, Borrower shall pay the County all costs of collection and enforcement, including reasonable attorneys‘ fees, filing fees, recording fees, and court costs, together with interest thereon at the rate charged in the Loan Agreement on matured, unpaid amounts with such interest to begin accruing upon the date request for payment is made. No assignment by the County of the right to receive payments under this Promissory Note shall effect Borrower's obligations or rights under this Promissory Note other than to make payments under this Note at the address designated by the County to the Borrower in writing.

Borrower shall upon demand pay to the County the amount of any and all expenses, including the fees and disbursements of the County's counsel and of any experts and agents, which the County may incur in connection with (i) the custody, preservation, use or operation of or sale of, collection from, or other realization upon any of the property financed in whole or in part by the proceeds of this Promissory Note; (ii) the exercise or enforcement of any of the rights of the County hereunder or (iii) the failure by Borrower to perform or observe any of the provisions hereof.

At the option of the County, any amount paid by the County for the collection of amounts due from the Borrower under this Promissory Note or to preserve or protect the County's rights under the Loan Agreement or Participation Agreement, both incorporated by reference as if fully set forth herein, shall become a part of, and bear interest at the interest rates as set forth in the Loan Agreement and this Promissory Note and shall become immediately due and payable by Borrower to the County upon demand by the County.

The failure of the County to insist, in any one or more instances, upon performance of any of the terms or covenants of this Promissory Note shall not be construed as a waiver or relinquishment of the County's right to the future performance of any such terms and covenants, and the obligations of Caldera With respect to such future performance shall continue in full force and effect. Time is of the essence with respect to every provision hereof. This Promissory Note shall be governed by the laws of the State of New Mexico (without giving effect to the State of New Mexico's choice of law provisions).

 
 

 

This Promissory Note is authorized by the Local Economic Development Act (Sections 5-10-1 to 5-10-13, NMSA 1978), Los Alamos County Ordinance No. 501, and Los Alamos County Ordinance No. 512.

IN WITNESS WHEREOF, Borrower has caused this Promissory Note to be executed for and on its behalf by its authorized representative signed below.

Caldera Pharmaceuticals, Inc., a Delaware corporation
/s/ Benjamin Warner/
Benjamin Warner,
Ph.D. President
 
Exhibit 4.3




CALDERA PHARMACEUTICALS, INC.

2005 STOCK OPTION PLAN

(Adopted Effective October 1, 2005)




 
 

 
 
TABLE OF CONTENTS
 
ARTICLE I     ESTABLISHMENT AND PURPOSE  1
1.1 Establishment  1
1.2 Purpose  1
1.3 Type of Plan  1
1.4 Term of Plan  1
ARTICLE II     DEFINITIONS  1
2.1 “Affiliate”   1
2.2 “Agreement”  1
2.3 “Beneficiary”  1
2.4 “Board”  2
2.5 “Cause”  2
2.6 “Change in Control”  2
2.7 “Code”  2
2.8 “Commission”  2
2.9 “Committee”  2
2.10 “Common Stock”  2
2.11 “Company”  2
2.12 “Disability”  2
2.13 “Exchange Act”  2
2.14 “Fair Market Value”   2
2.15 “Grant Date”  3
2.16 “Incentive Stock Option”  3
2.17 “Nonqualified Stock Option”  3
2.18 “Option”  3
2.19 “Option Period”   3
2.20 “Option Price”  3
2.21 “Participant”  3
2.22 “Plan”  3
2.23 “Representative”  3
2.24 “Retirement”  4
2.25 “Rule 16b-3”   4
2.26 “Securities Act”  4
2.27 “Termination of Employment”  4
2.28 “Transfer”  4
ARTICLE III     ADMINISTRATION  4
3.1 Structure  4
3.2 Authority  5
3.3 Liability and Indemnification  6
ARTICLE IV      STOCK SUBJECT TO PLAN   7
4.1 Number of Shares Available  7
4.2 Release of Shares  7
4.3 Conditions on Issuance of Shares  7
4.4 Shareholder Rights  7
4.5 Adjustment for Corporate Changes  8
ARTICLE V      ELIGIBILITY AND SELECTION   8
5.1 Eligibility  8
5.2 Selection of Participants  8
5.3 Options in Substitution  8
ARTICLE VI      STOCK OPTIONS   9
6.1 General  9
6.2 Grant of Options  9
6.3 Terms and Conditions  9
 
 
 

 
 
6.4 Effect of Termination of Employment  11
6.5 Information Available to Participants  12
6.6 Exercise of Options  12
6.7 Withholding on Exercise  12
6.8 Cash-Out of Option  12
ARTICLE VII      PROVISIONS APPLICABLE TO ACQUIRED STOCK  12
7.1 General Restriction on Transfer  12
7.2 Transfer On Change in Control  12
7.3 Estate Planning Transfers  13
7.4 Binding Effect of Plan  13
7.5 Limited Transfer During Offering  13
7.6 Rights of Repurchase  13
ARTICLE VIII       CHANGE IN CONTROL PROVISIONS   14
8.1 Consent to Board Action  14
8.2 Transfer of Shares  14
8.3 Accelerated Vesting  14
8.4 Definition of Change in Control  14
ARTICLE IX      MISCELLANEOUS   14
9.1 Amendment and Termination  14
9.2 Fail-Safe for Rule 16b-3  15
9.3 Fail-Safe for Mitigation of Excise Tax  15
9.4 No Creditor Rights  15
9.5 No Rights with Respect to Employment  15
9.6 Relationship to Other Benefits  15
9.7 Controlling Law  16
9.8 Waiver, Cumulative Rights  16
9.9 Notices  16
9.10 Successors and Assigns  16
9.11 Headings  16
9.12 Severability  16
9.13 Entire Agreement  16

 
 

 
 
CALDERA PHARMACEUTICALS, INC. 2005 STOCK OPTION PLAN
 
ARTICLE I      ESTABLISHMENT AND PURPOSE
 

1.1 Establishment. This instrument, and the plan of compensation hereby established, shall be known as the Caldera Pharmaceuticals, Inc. 2005 Stock Option Plan and shall be hereinafter referred to as the “Plan.” The Plan is hereby promulgated by Caldera Pharmaceuticals, Inc. (hereinafter referred to as the “Company”), effective as of October 1, 2005, as adopted by the Board of Directors of the Company.

1.2 Purpose. The purpose of the Plan is to provide additional incentive to persons who can make or are making, and can continue to make. substantial contributions to the growth and success of the Company, in order to attract and retain the employment and services of such persons and to encourage and reward such contributions, by providing these individuals with the opportunity to directly, on a long-term basis, participate in the Company’s growth and success through stock ownership; it being the judgment of the Board of Directors of the Company that so providing such additional incentive to such persons advances the overall interests of the Company’s business and enhances the value of the Company for all of its shareholders.

1.3 Type of Plan. Options granted under the Plan shall be either (i) Incentive Stock Options within the meaning of Section 422(b) of the Code, or (ii) nonqualified stock options, meaning options to purchase Common Stock in the Company which do not qualify as incentive stock options within the meaning of Section 422(b) of the Code. The Plan is intended to be an “unfunded” plan of compensation. It shall not constitute any type of “employee benefit plan” subject to the Employee Retirement Income Security Act of 1974 (“ERISA”). Options shall not be granted at a discounted Option Price under the Plan, so the Plan and options thereunder are intended to be exempt from Section 409A of the Internal Revenue Code.

1.4 Term of Plan. The Plan shall continue in effect from the effective date set forth in Section 1.1 hereof until the earlier of the Plan’s termination by the Board of Directors of the Company or otherwise, as provided in Section 9.1 hereof, or the date on which all shares of Common Stock available for issuance under the Plan have been issued and all restrictions on such shares under the terms of the Plan have lapsed.

 
ARTICLE II      DEFINITIONS
 

For purposes of the Plan, the following terms shall be defined as set forth below:

2.1 “Affiliate” shall mean any individual, corporation, partnership, association, joint-stock company, trust, unincorporated association or other entity (other than the Company) that directly, or indirectly through one or more intermediaries, controls, is controlled by, or is under common control with, the Company including, without limitation, any member of an affiliated group of which the Company is a common parent corporation as provided in Section 1504 of the Code.

2.2 “Agreement” shall mean, individually or collectively, any agreement entered into pursuant to Section 6.2 hereof, pursuant to which an Option is granted to a Participant, including any amendments thereto made pursuant to Section 9.1 hereof.

2.3 “Beneficiary” shall mean the person, persons, trust or trusts which have been designated by a Participant in his or her most recent written beneficiary designation filed with the Company to receive the benefits specified under the Plan upon such Participant’s death or to which Options or other rights are transferred if and to the extent permitted hereunder. If, upon a Participant’s death, there is no designated Beneficiary or surviving designated Beneficiary, then the term Beneficiary shall mean the person. persons, trust or trusts entitled by will or the laws of descent and distribution to receive such benefits.
 
 
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2.4 “Board” shall mean the Board of Directors of the Company.

2.5 “Cause” shall mean, for purposes of whether and when a Participant has incurred a Termination of Employment for Cause, any act or omission which permits the Company or an Affiliate to terminate the written agreement or arrangement between the Participant and the Company or the Affiliate, as the case may be, for “cause” as defined in such agreement or arrangement, or in the event there is no such agreement or arrangement or the agreement or arrangement does not define the term "cause" or a substantially equivalent term, then Cause shall mean (a) any act or omission which constitutes cause under the established practices, policies or guidelines of the Company or the Affiliate, as the case may be, applicable to the Participant; (b) the material breach of a fiduciary duty owing to the Company or the Affiliate, as the case may be, including, without limitation, fraud and embezzlement; (c) conduct or the omission of conduct on the part of the Participant which constitutes a material breach of any statutory or common-law duty of loyalty to the Company or the Affiliate, as the case may be; (d) failure to substantially perform the duties assigned by the Company to the reasonable satisfaction of the Board; or (e) serious misconduct, or negligence in the performance of duties to the Company, which is demonstrably and substantially injurious to the Company, any of its personnel or any of its business relationships.

2.6 “Change in Control” shall have the meaning set forth in Section 8.4.


2.7 “Code” shall mean the Internal Revenue Code of 1986, as amended or replaced from time to time, and the regulations thereunder.

2.8 “Commission” shall mean the Securities and Exchange Commission or any successor thereto.

2.9 “Committee” shall mean any person or persons who may be appointed or designated by the Board to administer the Plan, as described in Section 3.1 below.

2.10 “Common Stock” shall mean the shares of the Company’s regular voting common stock, no par value, whether presently or hereafter issued, and any other stock or security resulting from adjustment thereof as described hereinafter or the common stock of any successor to the Company which is designated for the purposes of the Plan.

2.11 “Company” shall mean Caldera Pharmaceuticals, Inc., a Delaware corporation, and includes any successor or assignee corporation or corporations into which the Company may be merged, changed or consolidated.

2.12 “Disability” shall mean a mental or physical illness that entitles the Participant to receive benefits under the long-term disability plan of the Company, or if the Participant is not covered by such a plan or the Participant is not an employee of the Company, a mental or physical illness that renders a Participant totally and permanently incapable of performing the Participant’s duties for the Company. Notwithstanding the foregoing, a Disability shall not qualify under this Plan if it is the result of (i) a willfully self-inflicted injury or willfully self-induced sickness; or (ii) an injury or disease contracted, suffered, or incurred while participating in a felony criminal offense. The determination of Disability shall be made by the Board. The determination of Disability for purposes of this Plan shall not be construed to be an admission of disability by any entity or person for any other purpose.

2.13 “Exchange Act” shall mean the Securities Exchange Act of 1934, as amended, and the rules and regulations promulgated thereunder.

2.14 “Fair Market Value” shall mean, as of any date, the value of one share of Common Stock, determined pursuant to the applicable method described below:

 
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(a) if the Common Stock is listed on a national securities exchange or quoted on NASDAQ, the closing price of the Common Stock on the relevant date (or, if such date is not a business day or a day on which quotations are reported, then on the immediately preceding date on which quotations were reported), as reported by the principal national exchange on which such shares are traded (in the case of an exchange) or by NASDAQ, as the case may be;

(b) if the Common Stock is not listed on a national securities exchange or quoted on NASDAQ, but is actively traded in the over-the-counter market, the average of the closing bid and asked prices for the Common Stock on the relevant date (or, if such date is not a business day or a day on which quotations are reported, then on the immediately preceding date on which quotations were reported), or the most recent preceding date for which such quotations are reported; and

(c) if, on the relevant date, the Common Stock is not publicly traded or reported as described in (a) or (b) above, the value determined in good faith by the Board.

2.15 “Grant Date” shall mean the date as of which the Board makes a grant of an Option to a person eligible to participate in the Plan, or any other date determined by the Board.

2.16 “Incentive Stock Option” means an Option intended to qualify as an incentive stock option within the meaning of section 422 of the Code and the regulations promulgated thereunder.

2.17 “Nonqualified Stock Option” means an Option not intended to qualify as an Incentive Stock Option.

2.18 “Option” shall mean a right, granted to a Participant under Section 6.1 hereof, to purchase Common Stock at a specified price during specified time periods.

2.19 “Option Period” shall mean the period during which an Option shall be exercisable in accordance with the related Agreement and Article VI.

2.20 “Option Price” shall mean the price at which the Common Stock may be purchased under an Option as provided in Section 6.3(b).

2.21 “Participant” shall mean a person who satisfies the eligibility conditions of Article V and with whom an Agreement has been entered into and remains effective under the Plan, and in the event a Representative is appointed for a Participant or another person becomes a Representative, then the term “Participant” shall mean such Representative. The term shall also include a trust for the benefit of the Participant, the Participant’s parents, spouse or descendants, or a custodian under a uniform gifts to minors act or similar statute for the benefit of the Participant’s descendants, to the extent permitted by the Board and not inconsistent with Rule 16b-3. Notwithstanding the foregoing, the term “Termination of Employment” shall mean the Termination of Employment of the person to whom the Option was originally granted.

2.22 “Plan” shall mean this Caldera Pharmaceuticals, Inc. 2005 Stock Option Plan, as herein set forth and as may be amended from time to time.

2.23 “Representative” shall mean (a) the person or entity acting as the executor or administrator of a Participant’s estate pursuant to the last will and testament of a Participant or pursuant to the laws of the jurisdiction in which the Participant had the Participant’s primary residence at the date of the Participant’s death; (b) the person or entity acting as the guardian or temporary guardian of a Participant subject to court supervision; (c) the person or entity which is the Beneficiary of the Participant upon or following the Participant’s death; or (d) any person to whom an Option has been permissibly transferred; provided that only one of the foregoing shall be the Representative at any point in time as determined under applicable law and recognized by the Board. Any Representative shall be subject to all terms and conditions applicable to the Participant.
 
 
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2.24 “Retirement” shall mean the Participant’s Termination of Employment upon or after attaining either the normal retirement age or the early retirement age as defined in the principal (as determined by the Board) tax-qualified plan of the Company, if the Participant is covered by such a plan, or if the Participant is not covered by such a plan, then age sixty-five (65).

2.25 “Rule 16b-3” shall mean Rule 16b-3, as from time to time in effect and applicable to the Plan and Participants, promulgated by the Commission under Section l6 of the Exchange Act.

2.26 “Securities Act” shall mean the Securities Act of 1933. as amended, and the rules and regulations promulgated thereunder.

2.27 “Termination of Employment” shall mean the occurrence of any act or event that actually or effectively causes or results in a person ceasing, for whatever reason, to be an employee, officer, director, consultant or other service provider of the Company, including, without limitation, Retirement, death, Disability, cessation at the election of the Participant, or dismissal by the Company. A transfer of employment from the Company to an entity which is an Affiliate as defined in Section 2.1 or from such an entity to the Company, shall not be a Termination of Employment, unless expressly determined by the Board. With respect to any person who is not an employee of the Company, the Board may determine and include in such person‘s Agreement more detailed or particular provisions concerning what act or event shall constitute a Termination of Employment with respect to that person.

2.28 “Transfer” shall mean any sale, gift, assignment, distribution, conveyance, pledge, hypothecation, encumbrance or other transfer of title, whether by operation of law or otherwise.

In addition, certain other terms used herein shall have the definitions given to such terms in the first place in which the terms are used.

 
ARTICLE III      ADMINISTRATION
 

3.1 Structure. The Plan shall be administered by the Board. The Board may appoint a committee (the “Committee”) comprised of one or more members of the Board to exercise designated functions of the Board under the Plan.

In the event that the Board appoints a Committee, the term “Board" shall be deemed to refer to the Committee to the extent required and consistent with the specific terms of the B0ard’s appointment of the Committee. A majority of the members of an appointed Committee shall constitute a quorum, and the acts of a majority of the members present at any meeting at which a quorum is present, or acts approved in writing by all of the members, shall be the acts of the Committee. A member of the Committee shall not exercise any discretion respecting himself or herself under the Plan. The Board shall have the authority to remove, replace or fill any vacancy of any member of the Committee upon notice to the Committee and the affected member. Any member of the Committee may resign upon notice to the Board. The Committee may allocate among one or more of its members, or may delegate to one or more of its agents, such duties and responsibilities as it determines.

Notwithstanding anything herein to the contrary, with respect to grants of Options to individuals who are and “Directors” (as such terms are defined for purposes of Section 16 of the Exchange Act) of the Company, at such time or in such circumstances as such individuals are subject to Section l6 of the Exchange Act, such grants shall be made and administered by a “Rule Committee” appointed by the Board. Such Rule l6b-3 Committee shall consist solely of two (2) or more “Non-Employee Directors” (as defined for purposes of Rule 16b-3) and shall otherwise be constituted and act in such manner as to permit such grants to Officers and Directors and related transactions under the Plan to be exempt from Section l6(b) of the Exchange Act in accordance with Rule 16b-3.

 
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Further notwithstanding anything herein to the contrary, with respect to grants of Options to individuals who are “Covered Employees” (as defined for purposes of Section 162(m) of the Code), at such time or in such circumstances as Section l62(m) of the Code may be applicable to the Company as a “Publicly Held Company” (as defined for purposes of Section l62(m) of the Code), such grants shall be made and administered by a “Section l62(m) Committee” appointed by the Board. Such Section l62(m) Committee shall consist solely of two (2) or more “Outside Directors” and shall otherwise be constituted and act in such manner as to permit such grants to Covered Employees to qualify as “Performance-Based Compensation” excludable from “Applicable Employee Remuneration” (as said terms are defined for purposes of Section 162(m) of the Code) in order that the Company not be subject to the limitation on deductions allowed for Applicable Employee Remuneration set forth in Section 162(m) of the Code.

Any Rule 16b-3 Committee or Section 162(m) Committee appointed by the Board shall function and have authority, and be subject to the constitutional and procedural provisions, as herein provided with respect to any Committee appointed by the Board, applicable to the making and administration of the grants of Options with respect to which the Committee is appointed. A Rule 16b-3 Committee or Section 162(m) Committee may be a subcommittee of a Committee otherwise appointed by the Board.

3.2 Authority. Subject to the terms of the Plan, the Board, and any Committee appointed by the Board subject to the specific terms of the Board’s appointment of the Committee, shall have the authority:

(a) to select those persons to whom Options may be granted from time to time; to determine whether to what extent Options are to be granted hereunder; to determine the number of shares of Common Stock to be covered by each Option granted hereunder; and to designate the type of Option to be granted in each instance;

(b) to determine the terms and conditions of any Option granted hereunder (including, but not limited to, the Option Price, the Option Period, any exercise restriction or limitation and any exercise acceleration, forfeiture, waiver or transfer condition or restriction regarding any Option or any shares of Common Stock relating thereto, any performance criteria and the satisfaction of such criteria);

(c) to determine the Fair Market Value of one share of Common Stock as of any date;

(d) to adjust the terms and conditions, at any time or from time to time, of any Option, subject to the limitations of Section 9.1;

(e) to provide for the forms of Agreements to be utilized in connection with the Plans and to include suitable confidentiality, non-solicitation, noncompetition and similar conditions in such Agreements as deemed necessary or desirable;

(f) to prescribe the manner in which and the form on which Participants may designate a Beneficiary;

(g) to determine the identity of a Participant’s Beneficiary or Representative for purposes of the Plan;

(h) to determine whether a Participant has a Disability or a Retirement; and to determine whether and with what effect a Participant has incurred a Termination of Employment;

(i) to determine what securities law requirements are applicable to the Plan, Options and the issuance of shares of Common Stock under the Plan and to require of a Participant that appropriate action be taken with respect to such requirements;

(j) to cancel, with the consent of the Participant or as otherwise provided in the Plan or an Agreement, outstanding Options;
 
 
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(k) to interpret and make final determinations with respect to the remaining number of shares of Common Stock available under the Plan;

(1) to determine the restrictions or limitations on the transfer of Common Stock; and to determine whether the Company or any other person has a right or obligation to purchase Common Stock from a Participant and, if so, the terms and conditions on which such Common Stock is to be purchased;

(m) to determine whether an Option is to be adjusted, modified or purchased, or is to become fully exercisable, under the Plan or the terms of an Agreement;

(n) to determine the permissible methods of Option exercise and payment;

(0) to adopt, amend and rescind such rules, guidelines, procedures and practices as, in its opinion, may be advisable in the administration of the Plan (and which may differ with respect to Options granted at different times or to different Participants);

(p) to suspend or delay any time period described in the Plan or any Agreement if the Board (or, as the case may be. Committee) determines the applicable action may constitute a violation of any law, or result in liability under any law to the Company or a shareholder of the Company, until such time as the action required or permitted shall not constitute such violation of law or result in such liability;

(q) to appoint and compensate agents, counsel, auditors or other specialists to aid it in the discharge of its duties; and

(r) to otherwise interpret and apply the terms and provisions of the Plan and any Option issued under the Plan (and any Agreement), and to otherwise supervise the administration of the Plan.

Any determination made by the Board (or, as the case may be, Committee) pursuant to the provisions of the Plan shall be made in its sole discretion, and in the case of any determination relating to an Option, may be made at the time of the grant of the Option or, unless in contravention of any express term of the Plan or an Agreement, at any time thereafter. All determinations and decisions made, and actions undertaken, by the Board (or, as the case may be, Committee) pursuant to the provisions of the Plan shall be final and binding for all purposes and on all persons, including the Company and Participants. No determination shall be subject to de novo review if challenged in court; instead, an arbitrary and capricious standard of review shall apply.

3.3 Liability and Indemnification.   No member of the Board or any Committee shall be liable for any action or determination made or taken by the member, or the Board or Committee, in good faith with respect to the Plan. Each member of the Board or any Committee shall be fully justified in relying or acting in good faith upon any report made by the independent public accountants of the Company, and upon any other information furnished in connection with the Plan. In no event shall any person who is or shall have been a member of the Board or any Committee be liable for any determination made or other action taken or any omission to act in reliance upon any such report or information, or for any action taken, including the furnishing of information, or failure to act, if in good faith.

Each person who is or at any time serves as a member of the Board or any Committee shall be indemnified and held harmless by the Company against and from (i) any loss, cost, liability, or expense that may be imposed upon or reasonably incurred by such person in connection with or resulting from any claim, action, suit or proceeding to which such person may be a party or in which such person may be involved by reason of any action or failure to act under the Plan, and (ii) any and all amounts paid by such person in satisfaction of judgment in any such action, suit. or proceeding relating to the Plan. Each person covered by this indemnification shall give the Company an opportunity, at its expense, to handle and defend such claim, action, suit or proceeding before such person undertakes to handle and defend the same on such pers0n’s own behalf. The foregoing right of indemnification shall not be exclusive of any other rights or indemnification to which such persons may be entitled under the articles or certificate of incorporation or by-laws of the Company. as a matter of law or otherwise, or any power that the Company may have to indemnify such persons or hold such persons harmless.
 
 
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ARTICLE IV      STOCK SUBJECT TO PLAN
 
 
4.1 Number of Shares Available. Subject to adjustment under Section 4.5, the total number of shares of Common Stock reserved and available for distribution pursuant to the exercise of Options under the Plan shall be 350,000* shares of Common Stock. Such shares may consist, in whole or in part, of authorized and unissued shares or treasury shares.

4.2 Release of Shares. Subject to Section 6.3(e), if any shares of Common Stock that are subject to any Option cease to be subject to an Option or are forfeited or repurchased, if any Option otherwise terminates without issuance of shares of Common Stock being made to the Participant, or if any shares (whether or not restricted) of Common Stock are received by the Company in connection with the exercise of an Option, including the satisfaction of tax withholding, such shares, in the discretion of the Board, may again be available for distribution in connection with Options under the Plan.

4.3 Conditions on Issuance of Shares. Shares of Common Stock issued in conjunction with an Option shall be subject to the terms and conditions specified herein and to such other terms, conditions and restrictions as the Board in its discretion may determine or provide in an Agreement.

The Company shall not be required to issue or deliver any certificates for shares of Common Stock, cash or other property prior to (i) the listing of such shares on any stock exchange or The NASDAQ Stock Market (or other public market) on which the Common Stock may then be listed (or regularly traded), (ii) the completion of any registration or qualification of such shares under Federal or state law, or any ruling or regulation of any government body which the Board determines to be necessary or advisable, and (iii) the satisfaction of any applicable withholding obligation.

The Board may require any person exercising an Option to make such representations, furnish such information and execute such other documents as it may consider appropriate in connection with the issuance or delivery of the shares of Common Stock in compliance with applicable law or otherwise; including, but not limited to, requiring each person purchasing shares to represent to and agree with the Company in writing that such person is acquiring the shares without a view to the distribution thereof.

The Company may cause any certificate for any share of Common Stock to be delivered on exercise of an Option to be properly marked with a legend or other notation reflecting the limitations on Transfer of such Common Stock as provided in this Plan or as the Board may otherwise require.

Fractional shares shall not be delivered, but shall be rounded to the next lower whole number of shares. No cash settlements shall be made with respect to fractional shares eliminated by rounding.

Any amounts owed to the Company or an Affiliate by the Participant of whatever nature may be offset by the Company from the value of any shares of Common Stock, cash or other thing of value under this Plan or an Agreement to be transferred to the Participant, and no shares of Common Stock, cash or other thing of value under this Plan or an Agreement shall be transferred unless and until all disputes between the Company, its Affiliates and the Participant have been fully and finally resolved and the Participant has waived all claims to such against the Company and its Affiliates to the satisfaction of the Board.

4.4 Shareholder Rights. No person shall have any rights of a shareholder as to shares of Common Stock subject to an Option until (i) after proper exercise of the Option, (ii) after such other action is taken by the person as may be required pursuant to the Agreement evidencing such Option, and (iii) such shares shall have been recorded on the Company’s official shareholder records as having been issued or transferred. Upon exercise of an Option or any portion thereof, the Company shall have sixty (60) days in which to issue the shares, and the Participant will not be treated as a shareholder for any purpose prior to such issuance. No adjustment shall be made for cash dividends or other rights for which the record date is prior to the date such shares are recorded as issued or transferred in the Company’s official shareholder records, except as provided herein or in an Agreement.
 
 

*As amended by the Board to 3,000,000
 
 
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4.5 Adjustment for Corporate Changes. In the event of any Company stock dividend, stock split, combination or exchange of shares, recapitalization or other change in the capital structure of the Company or any Affiliate, corporate separation or division of the Company (including, but not limited to, a split-up. spin-off, split-off or distribution to Company shareholders other than a normal cash dividend), sale by the Company of all or a substantial portion of its assets, reorganization, rights offering, a partial or complete liquidation, or any other corporate transaction or event involving the Company or its Affiliates, then the Board shall adjust or substitute, as the case may be, the number of shares of Common Stock available for Options under the Plan, the number of shares of Common Stock covered by outstanding Options, the exercise price per share of outstanding Options, and performance conditions and any other characteristics or terms of the Options as the Board shall deem necessary or appropriate to reflect equitably the effects of such changes to the Participants; provided, however, that any fractional shares resulting from such adjustment shall be eliminated by rounding to the next lower whole number of shares (and no cash settlements shall be made with respect to fractional shares eliminated by rounding).

 
ARTICLE V      ELIGIBILITY AND SELECTION
 
 
5.1 Eligibility. The persons eligible to participate in the Plan and be granted Options shall be employees, officers, directors, consultants, investors or other service providers of the Company or any Affiliate.
For purposes of this Section 5.1, prospective employees, officers, directors, consultants, investors or other service providers of the Company or any Affiliate shall be eligible to participate in the Plan and be granted Options in connection with and in furtherance of written offers of employment, retention or engagement, prior to the date any such person commences employment or first performs services for the Company or the Affiliate; provided that any Option granted to such person shall be granted contingent on such person commencing employment or performance of services for the Company or the Affiliate, and shall be exercisable no earlier than the date on which such person commences employment or first performs service for the Company or the Affiliate.

5.2 Selection of Participants. Of those persons eligible to participate in the Plan as described in Section 5.1, the Board shall, from time to time and in its sole discretion, select the persons to be granted Options and shall determine the terms and conditions with respect thereto. The Board may give consideration to such factors as deemed relevant by the Board to making such selection and determination. Only employees and prospective employees shall be eligible to receive grants of Incentive Stock Options.

5.3 Options in Substitution. Options (including cash in respect of fractional shares) may be granted under the Plan from time to time in substitution for options held by employees, officers, directors, consultants or service providers of other corporations who are about to become employees. officers, directors, consultants, investors or service providers of the Company or an Affiliate as the result of a merger or consolidation of the employing corporation with the Company or an Affiliate, or the acquisition by the Company or an Affiliate of the assets of the employing corporation, or the acquisition by the Company or an Affiliate of the stock of the employing corporation, as the result of which it becomes an Affiliate. The terms and conditions of the Options so granted may vary from the terms and conditions set forth in this Plan at the time of such grant as the Board may deem appropriate to conform, in whole or in part, to the provisions of the options in substitution for which they are granted.
 
 
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ARTICLE VI STOCK OPTIONS
 
 
6.1 General. The Board shall have authority to grant Options under the Plan at any time or from time to time. An Option shall entitle the Participant to receive shares of Common Stock upon exercise of such Option, subject to the Participant’s satisfaction in full of the conditions, restrictions or limitations imposed in accordance with the Plan and an Agreement (which may differ from other Agreements), including, without limitation, payment of the Option Price.

6.2 Grant of Options. The grant of an Option shall occur as of the date the Board determines. Each Option granted under the Plan shall be evidenced by an Agreement, in a form prescribed or approved by the Board, which shall embody the terms and conditions of such Option and which shall be subject to the express terms and conditions set forth in the Plan. A person selected by the Board to receive an Option shall not become a Participant and have any rights with respect to such Option unless and until a fully executed copy of the Agreement has been delivered to the person or office designated by the Board and the recipient of the Option grant has otherwise complied with any and all applicable requirements set forth by the Board as part of the grant of the Option.

Each Option shall be designated in the Option Agreement as either an Incentive Stock Option or a Nonqualified Stock Option. However, notwithstanding such designation, to the extent that the aggregate Fair Market Value of the shares of Common Stock with respect to which Incentive Stock Options are exercisable for the first time by the Optionee during any calendar year (under all plans of the Company and any Parent or Subsidiary) exceeds $100,000, such Options shall be treated as Nonqualified Stock Options. For purposes of this Section 6.2, Incentive Stock Options shall be taken into account in the order in which they were granted. The Fair Market Value of the shares of Common Stock shall be determined as of the time the Option with respect to such shares is granted.

Neither the Plan nor any Option shall confer upon an Optionee any right with respect to continuing the Optionee’s relationship as a Service Provider with the Company, nor shall they interfere in any way with the Optionee’s right or the Company’s right to terminate such relationship at any time, with or without cause.

6.3 Terms and Conditions. Options shall be subject to such terms and conditions as shall be determined by the Board (or the Committee acting for the Board pursuant to Section 3.2), including the following:
(a) Option Period. The Option Period of each Option shall be fixed by the Board. Notwithstanding anything herein to the contrary, unless otherwise determined by the Board and provided in an Agreement, the Option Period of each Option shall be ten (10) years from the Grant Date of the Option. Moreover, in the case of an Incentive Stock Option granted to a Participant who, at the time of the grant, owns stock representing more than ten percent (10%) of the total combined voting power of all classes of stock of the Company or any Affiliate, the term of the Incentive Stock Option shall be five (5) years from the Grant Date or such shorter term as may be provided in the Agreement.

(b) Option Price. The Option Price per share of the Common Stock purchasable under an Option shall be determined by the Board. The Option Price per share shall not be less than the F air Market Value of a share of Common Stock made subject to the Option, determined as of the Grant Date. Moreover, in the case of an Incentive Stock Option granted to a Participant who, at the time of the grant owns stock representing more than ten percent (10%) of the total combined voting power of all classes of stock of the Company or any Affiliate, the per share Option Price shall be no less than l 10% of the Fair Market Value per share on the Grant Date.

(c) Execution of Related Documents. A Participant shall be required to enter into such non-competition, non-solicitation and confidentiality agreement or agreements as the Board shall specify, or such provisions may be included in the Option Agreement.
 
 
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(d) Vesting and Exercisability. Options shall become vested and be exercisable as determined by the Board and set forth in each Agreement. An Agreement shall state, with respect to all or designated portions of the shares of Common Stock subject thereto, the time at which, the conditions upon which, or the installments in which the Option shall become vested and be exercisable during the Option Period. The Board may establish requirements for vesting and exercisability based on (i) periods of employment or rendering of services, (ii) the satisfaction of performance criteria with respect to the Company or the Participant (or both), or (iii) both periods of employment or rendering of services and satisfaction of performance criteria.
Notwithstanding anything herein to the contrary, unless otherwise determined by the Board and provided in the Agreement, each Option shall become vested and be exercisable according to the following provisions:

(1) Prior to the second anniversary of the Grant Date, no portion of the Option shall be vested and the Option shall be forfeitable in its entirety.
(2) On the second anniversary of the Grant Date, 25% of the Option
shall be vested and nonforfeitable.
(3) On the third anniversary of the Grant Date, 50% of the Option shall
be vested and nonforfeitable.
(4) On the fourth anniversary of the Grant Date. 75% of the Option shall be vested and nonforfeitable.
(5) On the fifth anniversary of the Grant Date, the entire Option shall be vested and nonforfeitable.

In the case of any Option which, at the Grant Date, is granted with provisions for vesting and exercisability at a later date or in installments, whether by determination of the Board or by operation of the preceding paragraph, the Board may thereafter, at any time and in its sole discretion, waive or modify such vesting requirements with respect to such Option, in whole or in part, and accelerate the exercisability of all or a portion of the Option.

(e) Method of Payment. Unless otherwise determined by the Board and provided in an Agreement, payment of the Option Price under each Option shall be made in full or in part by cash or by check. No shares of Common Stock shall be issued on exercise of an Option until full payment therefore has been made and all other applicable conditions have been satisfied, as determined by the Board. Alterative methods of payment the Board may consider shall include: (i) tendering other shares of Common Stock Which have either been owned by the Participant for more than six months on the date of surrender or were acquired upon exercise of the Option for which payment is being made and which, in either case, have a Fair Market Value on the date of surrender equal to the aggregate Option Price of the shares for which the Option is being exercised; (ii) consideration received by the Company under a broker-assisted cashless exercise program implemented by the Company with respect to the Plan; (iii) a loan from the Company on terms acceptable to the Board; or (iv) any combination of the foregoing methods of payment. Any method of payment, such as cashless exercise and tendering of shares just then being acquired, shall not be available for the exercise of Incentive Stock Options where such method of payment would adversely affect the federal income tax treatment of such exercise.

(f) Nontransferability of Options. Except as specifically provided herein or in an Agreement, no Option or interest therein shall be transferable by the Participant other than by will or by the laws of descent and distribution, and an Option shall be exercisable during the Participant’s lifetime only by the Participant.

(g) Designation of Beneficiary. A Participant may designate a Beneficiary who may exercise the Participant’s Option after the Participant’s death, subject to the provisions of the Plan. Such designation shall be made in such manner and on such form as shall be prescribed by the Company.
 
 
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6.4 Effect of Termination of Employment. Except as otherwise determined by the Board and set forth in an Agreement, if a Participant incurs a Termination of Employment for any reason prior to the expiration of the Option Period of any Option, the Option, if not vested and exercisable on the date of Termination of Employment, or any portion of the Option that is not vested and exercisable on the date of the Termination of Employment, shall expire and be forfeited, and shall be void for all purposes, immediately on the date of Termination of Employment.
Except as otherwise determined by the Board and set forth in an Agreement, in the case of a Participant who incurs a Termination of Employment prior to the expiration of the Option Period of any Option, the Option, if vested and exercisable on the date of Termination of Employment, or any portion of the Option that is vested and exercisable on the date of Termination of Employment, shall continue to be exercisable only for the applicable extended time period following such Termination of Employment set forth hereinafter and shall otherwise cease to be exercisable as of the close of business on the date of Termination of Employment.

(a) In the event of Termination of Employment constituting Retirement, such Option or such portion thereof may be exercised by the Participant until the end of the ninety (90) day period commencing with the date of Retirement or, if earlier, the expiration of the Option Period.

(b) In the event of Termination of Employment due to death, such Option or such portion thereof may be exercised by the Participant’s Representative until the end of the twelve (12) month period commencing With the date of the Participant’s death or, if earlier, the expiration of the Option Period.

(c) In the event of Termination of Employment due to Disability, such Option or such portion thereof may be exercised by the Participant or, in the event the Participant is legally incompetent, the Participant's Representative until the end of the twelve (12) month period commencing with the date of Disability or, if earlier, the expiration of the Option Period.

(d) In the event of Termination of Employment at the election of the Participant, other than on account of Retirement, death or disability, such Option or such portion thereof may be exercised by the Participant until the end of the ninety (90) day period commencing with the date of Termination of Employment or, if earlier, the expiration of the Option Period; provided that if a Participant elects such Termination of Employment without appropriate or agreed notice and agreed termination terms, such Option or such portion thereof shall cease to be exercisable automatically upon first notification to the Company by the Participant of such termination, with no extended time period for any exercise of the Option or any portion thereof.

(e) In the event of Termination of Employment due to dismissal by the Company or an Affiliate, as the case may be, such Option or such portion thereof may be exercised by the Participant until the end of the ninety (90) day period commencing with the date of Termination of Employment or, if earlier, the expiration of the Option Period.

(f) Notwithstanding anything in the preceding subparagraphs (a) through (e) to the contrary, in the event of Termination of Employment of a Participant by the Company or an Affiliate for Cause, such Option or such portion thereof shall cease to be exercisable automatically upon first notification to the Participant by the Company or the Affiliate of such termination, with no extended time period for any exercise of the Option or any portion thereof. If a Participant’s employment or services are suspended pending an investigation of whether the Participant’s employment or services should be terminated for Cause, all of the Participant’s rights under any Option shall likewise be suspended during the period of such investigation.

Notwithstanding anything herein to the contrary, the Board may, at any time and in its sole discretion, further extend or modify the extended time periods for exercisability set forth in this Section 6.4, or waive or modify the operation of the provisions of this Section 6.4 as regards elective Termination of Employment without appropriate or agreed notice and agreed termination terms or Termination of Employment for Cause. However, an Incentive Stock Option shall not be exercisable more than ninety (90) days after the Participant’s Termination of Employment except as provided in Subsection (c) above regarding Disability.
 
 
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6.5 Information Available to Participants. At least annually, the Company shall make available to all Participants copies of the Company’s financial statements for its most recently completed fiscal year. Except as may be required by applicable law, neither the Company nor the Board shall have any duty or obligation to provide or make available to any Participant any other disclosures or information regarding the Company, and no Participant shall have any right to obtain any other disclosures or to receive any other information regarding the Company, in connection with the grant or exercise of any Option.

6.6 Exercise of Options.   An Option which is vested and exercisable shall be exercised by a Participant (or a Representative), in whole or in part at any time during the Option Period, by giving written notice to the Company, in such form and manner as the Board may prescribe, specifying the number of shares of Common Stock attributable to the Option to be purchased. Such notice of exercise given to the Company shall be accompanied by payment in full of the Option Price and any other executed documents required by the Board.

6.7 Withholding on Exercise. No later than the date as of which an amount first becomes includible in the gross income of the Participant for Federal income tax purposes with respect to any Option, the Participant shall pay to the Company (or other entity identified by the Board), or make arrangements satisfactory to the Company or other entity identified by the Board regarding the payment of any Federal, state, local or other foreign taxes of any kind required by law to be withheld with respect to such amount. The obligations of the Company under the Plan shall be conditional on such payment or arrangements, and the Company and its Affiliates shall, to the extent permitted by law, have the right to deduct any such taxes from any payment otherwise due to the Participant.

6.8 Cash-Out of Option. On receipt of written notice of exercise of an Option at any time prior to a Change in Control, the Board may elect, at any time, to cash-out all or any portion of the Option, provided such action would not violate Code Section 409A, by paying to the Participant an amount, in cash, equal to the excess of the Fair Market Value of a share of Common Stock as of the date of exercise over the Option Price, multiplied by the number of shares of Common Stock subject to the Option elected to be cashed-out by the Board. The Board may elect to cash-out all or any portion of an outstanding Option at any other time, using the same formula as described above for determining the consideration to be paid, regardless of any exercise notice or Change in Control. Cash-outs relating to Options held by Participants who are actually or potentially subject to Section l6 of the Exchange Act shall comply with Rule 16b-3, to the extent applicable. The Board may elect to offset against any cash-out payment under this Section 6.8 any amounts outstanding under any indebtedness or obligations owed by the Participant to the Company or its Affiliates.

 
ARTICLE VII PROVISIONS APPLICABLE TO ACQUIRED STOCK

 
7.1 General Restriction on Transfer. Except as provided in Sections 6.3(e) or 7.3, a Participant may not Transfer any shares of Common Stock acquired pursuant to the exercise of an Option until the effective date of a Change in Control. Notwithstanding anything herein to the contrary, the Board may, at any time and in its sole discretion, waive or modify the restriction on Transfer set forth in this Section 7.1 with respect to any or all shares of Common Stock acquired by a Participant pursuant to the exercise of an Option.

7.2 Transfer On Change in Control. A Participant may Transfer, or may be required to sell, shares of Common Stock acquired pursuant to the exercise of an Option upon the effective date of a Change in Control, as provided in Section 8.2. Notwithstanding anything herein to the contrary, the Board may, at any time and in its sole discretion. provide that corporate transactions in addition to those specified in Section 8.4, as constituting a Change in Control, shall constitute events upon the effective date of which a Participant may Transfer any or all of the Shares of Common Stock acquired by the Participant pursuant to the exercise of an Option.
 
 
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7.3 Estate Planning Transfers. Notwithstanding anything herein to the contrary, a Participant may at any time make a Transfer of shares of Common Stock received pursuant to the exercise of an Option to his or her parents, spouse or descendants or to any trust for the benefit of the foregoing or to a custodian under a uniform gifts to minors act or similar statute for the benefit of any of the Participant’s descendants.

7.4 Binding Effect of Plan. Any otherwise permitted Transfer of shares acquired pursuant to the exercise of an Option shall not be permitted or valid unless and until the transferee agrees to be bound by the provisions of this Plan, and any provision restricting Common Stock under the Agreement; provided that “Termination of Employment” shall continue to refer to the Termination of Employment of the Participant.

7.5 Limited Transfer During Offering. In the event there is an effective registration statement under the Securities Act pursuant to which shares of Common Stock shall be offered for sale in an underwritten offering, a Participant shall not, during the period requested by the underwriters managing the registered offering, effect any public sale or distribution of shares received directly or indirectly pursuant to an exercise of an Option.

7.6 Rights of Repurchase. Prior to the effective date of a Change in Control, upon a Termination of Employment of a Participant, the Company shall have the right to repurchase all or any portion of the shares of Common Stock acquired pursuant to the exercise of the Participant’s Option (the “Acquired Shares”), izvhether held by the Participant or by a transferee of the Participant as permitted under Section 7.3 (a “Permitted Transferee”), on the following terms and conditions:

(a) The Company may exercise such right by delivery of written notice (the “Repurchase Notice”) to the Participant or any Permitted Transferees within ninety (90) days after the date of the Participant’s Termination of Employment or, if later, within ninety (90) days after the date the Participant or the Participant’s Representative exercises the Participant’s Option following the Participant’s Termination of Employment (pursuant to Section 6.4) to obtain Acquired Shares. The Repurchase Notice shall set forth the number of Acquired Shares to be acquired by the Company from the Participant or the Permitted Transferees, the aggregate consideration to be paid for the Acquired Shares and the time and place for the closing of such transaction.

(b) The number of Acquired Shares to be repurchased by the Company shall first be satisfied to the extent possible from the Acquired Shares held by the Participant at the date of delivery of the Repurchase Notice. If the number of Acquired Shares then held by the Participant is less than the total number of Acquired Shares the Company has elected to repurchase, then the Company shall purchase the remaining Acquired Shares elected to be repurchased from the other holders thereof, pro rata according to the number of shares held by each such holder at the date of delivery of the Repurchase Notice (determined as close as practical to the nearest whole shares).

(c) The repurchase of Acquired Shares shall be closed at the Company’s executive offices, or at such other location as may be designated by the Company, within twenty (20) days after the date of delivery of the Repurchase Notice. At the closing, the Company shall pay the purchase price to the Participant or any other holders of the Acquired Shares, and the Participant and any other holders of the Acquired Shares being repurchased shall deliver the certificate or certificates representing such Acquired Shares to the Company or its nominee, accompanied by duly executed stock powers. The Company shall be entitled to receive customary representations and warranties from the seller regarding the sale of Acquired Shares (including representations and warranties regarding good title to such shares, free and clear of any liens or encumbrances) and to require a seller’s signature to be guaranteed by a national bank or reputable securities broker.
 
(d) The purchase price per share to be paid for the Acquired Shares repurchased by the Company shall be equal to the Fair Market Value of each such Acquired Share as of the date of the Participant’s Termination of Employment.
 
 
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(e) The Company shall make payment for Acquired Shares by, at the Company’s option, (i) a check or wire transfer of funds to the extent such payment would not cause the Company to violate the General Corporation Law of the State of Delaware and would not cause the Company to breach any agreement to which it is a party relating to the indebtedness for borrowed money or other material agreement, (ii) a subordinated promissory note of the Company bearing interest (payable quarterly in cash unless otherwise prohibited) at the rate of 6% per annum, with a principal payment due on the fifth anniversary of the date of issuance and which shall be subordinated on terms and conditions satisfactory to the holders of the Company’s indebtedness for borrowed money, or (iii) a combination of (i) and (ii) above in such proportions as the Company may determine in its sole discretion. In addition, the Company may pay the purchase price by offsetting amounts outstanding under an indebtedness or obligations owed by the Participant to the Company or its Affiliates.
 
 
ARTICLE VIII CHANGE IN CONTROL PROVISIONS
 
 
8.1 Consent to Board Action. A Participant, in the course of and as a condition to exercising an Option to acquire shares of Common Stock, shall waive all rights to object to or dissent from a proposed Change in Control which is approved by the Board, and shall agree to consent and raise no objection to such approved Change in Control; and, without limiting the generality of the foregoing, the Participant shall agree to (a) vote the Participant’s shares to approve the terms of such approved Change in Control and (b) waive any appraisal rights that the Participant would have with respect to such approved Change in Control.

8.2 Transfer of Shares. On and after the effective date of a Change in Control, a Participant may Transfer shares of Common Stock acquired pursuant to the exercise of an Option; provided that in the event of a Change in Control approved by the Board, structured as a sale of shares of Common Stock, a Participant shall Transfer all shares of Common Stock acquired by the Participant, pursuant to the exercise of an Option, on the same terms as the other holders of Common Stock of the Company.

8.3 Accelerated Vesting. Notwithstanding any other provision of the Plan or in an Agreement to the contrary, in the event of a Change in Control (as defined in Section 8.4), the Board shall have full discretion to provide that any Options outstanding as of the date of the Change in Control which are not then fully vested and exercisable become fully vested and exercisable to the full extent of the original grant.

8.4 Definition of Change in Control. For purposes of this Plan, a “Change in Control” shall be deemed to have occurred at such time as (a) a person or a group (within the meaning of Sections 13(d) or 14(d)(2) of the Exchange Act), other than a person who is an existing holder of capital stock of the Company or a group consisting solely of existing holders of capital stock of the Company, becomes the “beneficial owner” (as defined in Rule 13d-3 promulgated under the Exchange Act) of more than fifty (50%) percent of the Company’s total outstanding capital stock; (b) a sale, lease or exchange of substantially all of the Company’s assets and related business to a third party unaffiliated with an existing holder of capital stock of the Company; or (c) a merger of the Company into or consolidation with another corporation which is unaffiliated with the stockholders or management of the Company and, after giving effect to such merger or consolidation, the existing holders of capital stock of the Company immediately prior to such merger or consolidation own less than fifty-one percent (51%) of the capital stock of the surviving entity.

 
ARTICLE IX MISCELLANEOUS
 

9.1 Amendment and Termination. The Board may amend or terminate the Plan at any time, but no amendment or termination shall be made which would impair the rights of a Participant under an Option theretofore granted without the Participant’s consent, except to the extent such amendment or termination is made pursuant to express provisions of the Plan or an Agreement or is necessary for the Plan or an Option to comply with any applicable law, regulation or rule. If not sooner terminated, the Plan shall automatically expire and terminate on the tenth anniversary of its Effective Date. Options outstanding on the Plan’s termination date shall continue in effect thereafter in accordance with their respective terms.
 
 
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The Board may amend the terms of any Option theretofore granted as set forth in an Agreement, prospectively or retroactively, but no such amendment shall be made which would impair the rights of any Participant without the Participant’s consent, except to the extent such an amendment is made pursuant to express provisions of the Plan or an Agreement or is necessary for the Plan or an Option to comply with any applicable law, regulation or rule.

9.2 Fail-Safe for Rule 16b-3. With respect to persons subject to Section 16 of the Exchange Act, transactions under this Plan are intended to comply with all applicable conditions of Rule 16b-3. To the extent any provision of the Plan or action by the Board fails to so comply, it shall be deemed null and void, to the extent permitted by law and deemed advisable by the Board. In the event the Plan does not include a provision required by Rule 16b-3 to be stated herein, such provision (other than one relating to eligibility requirements or the price and amount of Options) shall be deemed to be incorporated by reference into the Plan with respect to Participants subject to Section 16.
If at the time a Participant incurs a Termination of Employment (other than due to Cause) or if at the time of a Change in Control. the Participant is subject to “short-swing” liability under Section 16 of the Exchange Act, any time period provided for under the Plan or an Agreement, to the extent necessary to avoid the imposition of such liability, shall be suspended and delayed during the period the Participant would be subject to such liability, but such suspension and delay shall not be for more than six (6) months and one (1) day and not to exceed the Option Period, whichever is shorter.

9.3 Fail-Safe for Mitigation of Excise Tax. Except as otherwise provided in an Agreement, if any payment or right accruing to a Participant under this Plan (without the application of this provision), either alone or together with other payments or rights accruing to the Participant from the Company (“Total Payments”), would constitute a “parachute payment” (as defined in Section 280G of the Code), such payment or right shall be reduced to the largest amount or greatest right that will result in no portion of the amount payable or right accruing under the Plan being subject to an excise tax under Section 4999 of the Code or being disallowed as a deduction under Section 280G of the Code. The determination of the amount of any potential reduction in the rights or payments shall be made by the Board in good faith after consultation with the Participant and shall be communicated to the Participant. The Participant shall cooperate in good faith with the Board in making such determination and providing the necessary information for this purpose. The foregoing provisions of this paragraph shall apply with respect to any person only if, after reduction for any applicable Federal excise tax imposed by Section 4999 of the Code and Federal income tax imposed by the Code, the Total Payments accruing to such person would be less than the amount of the Total Payments as reduced, if applicable, under the foregoing provisions of the Plan and after reduction for only Federal income taxes.

9.4 No Creditor Rights. Unless otherwise provided in this Plan or in an Agreement, no Option shall be subject to the claims of Participants creditors and no Option may be transferred, assigned, alienated or encumbered in any way other than by will or the laws of descent and distribution or to a Representative upon the death of the Participant.

9.5 No Rights with Respect to Employment. Nothing contained herein shall be deemed to alter the employment relationship between the Company or its Affiliate and a Participant, or the contractual relationship between the Company or its Affiliate and a Participant if there is a written contract regarding such relationship. Nothing contained herein shall be construed to constitute a contract of employment or a contract for services between the Company or its Affiliate and a Participant. The Company or its Affiliate, as the case may be, and each of the Participants shall continue to have the right to terminate the employment or service relationship at any time for any reason, except as provided in a written contract.

9.6 Relationship to Other Benefits. No payment under the Plan shall be taken into account in determining any benefits under any retirement or welfare benefit plan of the Company, unless otherwise specifically provided in such plan of the Company.
 
 
15

 
 
The adoption of the Plan by the Board shall not be construed as creating any limitations on the power of the Company or the Board to adopt such other incentive arrangements as the Company or the Board may deem desirable, including, without limitations, any stock appreciation right, phantom stock or restricted stock arrangement and the granting of stock options otherwise than under the Plan, and such arrangements may be applicable either generally or only in specific cases.

9.7 Controlling Law. The Plan, all Agreements and all Options granted and actions taken thereunder shall be governed by and construed in accordance with the laws of the State of Delaware (other than its law respecting choice of law). The Plan and all Agreements shall be construed to comply with all applicable law and to avoid liability to the Company, its Affiliates and (to the extent feasible) to Participants, including, without limitation, liability under Section 16(b) of the Exchange Act.

9.8 Waiver, Cumulative Rights. The failure or delay of either the Company or a Participant to require performance by the other party under any provision of the Plan or an Agreement shall not affect the Company’s or the Participant’s right to require such performance, unless and until such performance has been waived in writing. Each and every right provided by the Plan and an Agreement shall be cumulative and may be exercised from time to time in whole or in part (unless otherwise specifically provided).

9.9 Notices. Any notice which either the Company or a Participant may be required or permitted to provide to the other party under the Plan or an Agreement shall be in writing and shall be deemed sufficiently given if personally delivered or sent by either facsimile, overnight courier or postage paid first class mail. Notices sent by mail shall be deemed received three (3) business days after mailed, but in no event later than the date of actual receipt. Notices shall be directed, if to a Participant, to the Participant’s address indicated in the Company’s business records or as otherwise designated in writing delivered by the Participant to the Company to apply for purposes of the Plan; and, if to the Company, to the Secretary of the Company at the Company’s principal executive office or to such other officer of the Company at such address as may be designated in an Agreement or otherwise in writing delivered by the Company to the Participant.

9.10 Successors and Assigns. This Plan and an Agreement shall inure to the benefit of and be binding upon each successor and assign of the Company. All obligations imposed upon a Participant, and all rights granted to the Company under this Plan and an Agreement, shall be binding upon the Participant’s heirs, legal representatives and successors.

9.11 Headings. The headings contained in this Plan or in an Agreement are for reference purposes only and shall not affect the meaning or interpretation of this Plan or an Agreement.

9.12 Severability. If any provision of this Plan and an Agreement shall for any reason be held to be invalid or unenforceable, such invalidity or unenforceability shall not affect any other provision hereby or thereof, and this Plan and the Agreement shall be construed as if such invalid or unenforceable provision were omitted.

9.13 Entire Agreement. This Plan and, with respect to any Participant, the Agreement entered into with the Participant pursuant to which an Option is granted, including any Exhibits thereto, shall constitute the entire agreement with respect to the subject matter hereof and thereof; provided that in the event of any inconsistency between the Plan and the Agreement, the terms and conditions of the Plan shall control.

IN WITNESS WHEREOF, the Company has caused this instrument to be executed on its behalf by the undersigned officer if the Company, as duly authorized by its Board of Directors, as of the 1 st day of October, 2005.
 
 
  CALDERA PHARMACEUTICALS, INC.  
 
By: /Benjamin Warner/  
  Title: President  
     
     
 
 
 
 
16

Exhibit 4.4

Below is a list of each warrant holder, the number of warrants held and the date of issuance in connection with the form of warrant in Exhibit 4.1.

Name
Number of Warrants
Date Issued
 
Eight Family Trust
13,500
March 22, 2011
Chang-Tai Hsieh
8,772
March 24, 2011
Joseph Amato – Revocable Trust
26,316
April 7, 2011
Sin Fa Wang and Mei Wang
8,772
April 11, 2011
S/L Trilling Trust
17,544
April 14, 2011
Benjamin Warner
25,035
April 15, 2011
Douglas Jensen
5,000
April 18, 2011
Mark Litwin
17,544
April 26, 2011
Robert S Coleman
8,772
April 27, 2011
2030 Investors LLC/401K Plan
25,000
May 12, 2011
Sarah Abrams
8,772
May 12, 2011
Matthew Abrams
8,772
May 12, 2011
Joseph W and Patricia G Family Trust
43,860
May 16, 2011
James Jensen
35,000
June 7, 2011
Sutter Securities Incorporated
40,000
July 7, 2011
Chan Kei Blu
26,316
September 8, 2011
Louitt & V. Hannan, Inc. Salary Deferral Plan, FBO J. Thomas Hannan
8,772
September 13, 2011
George Mains
8,772
October 13, 2011
Saunders and Diane Kohn
35,000
October 17, 2011
Newbridge Securities
2,800
October 17, 2011
David Steinhardt and Tobi B Richman-Steinhardt Trust
10,088
January 22, 2012
Jeff Stewart
15,000
October 31, 2011
 
Exhibit 5.1
GRACIN & MARLOW, LLP.
The Chrysler Building
405 Lexington Avenue, 26 th Floor
New York, New York 10174
Telephone (212) 907-6457
Facsimile: (212) 208-4657
 
 
 
February 14, 2011
 

The Board of Directors
Caldera Pharmaceuticals, Inc.
278 DP Road, Suite D
Los Alamos, New Mexico 87544

Re:    Registration Statement on Form S-1
 
Gentlemen:

At your request, we have examined the Registration Statement on Form S-1 (the "Registration Statement") filed by Caldera Pharmaceuticals, Inc., a Delaware corporation (the "Company"), that is intended to register under the Securities Act of 1933, as amended (the "Securities Act"), 1,398,264 shares of the Company's common stock (the "Shares"), of which 633,144 Shares are issuable upon exercise of warrants and the conversion of preferred stock.

We have examined originals or certified copies of such corporate records of the Company and other certificates and documents of officials of the Company, public officials and others as we have deemed appropriate for purposes of this letter. We have assumed the genuineness of all signatures, the authenticity of all documents submitted to us as originals, the conformity to authentic original documents of all copies submitted to us as conformed and certified or reproduced copies.

Based on the foregoing, we are of the opinion that under Delaware law that 765,120 Shares have been duly authorized and will be legally issued, fully paid and non-assessable when paid for and issued in accordance with the terms of the Registration Statement and that 633,144 Shares have been duly authorized and will be legally issued, fully paid, and non-assessable upon exercise of warrants or conversion of preferred stock.

We consent to the use of this opinion as an Exhibit to the Registration Statement and to the use of our name in the prospectus constituting a part thereof.
 
Very truly yours,
 
 
/s/ Gracin & Marlow, LLP
      Gracin & Marlow, LLP 

 

 

 

Exhibit 10.1
Caldera Pharmaceuticals, Inc.
EMPLOYMENT AGREEMENT

Agreement made this 25 day of October, 2006, between Caldera Pharmaceuticals, Inc., a Delaware corporation (hereinafter referred to as “Company") and Benjamin Warner, hereinafter referred to as “Employee.”

In consideration of the mutual covenants and agreements hereinafter set forth, the Company and Employee agree as follows:

1. Term of Employment. The term of employee’s employment shall commence on January 1, 2006, and shall continue until terminated as provided for herein.

(a) Duties & Responsibilities. Employee will report directly to the company Board of Directors. Employee will have the responsibilities and duties of Chief Executive as well as other duties on behalf of the company as assigned by the Board of Directors.

2. Compensation.

(a) Base Salary. Employee shall be paid a base salary ("Base Salary") at an annual rate of payable in bi-weekly installments consistent with Company's payroll practices and subject to all applicable employment and withholding taxes.

(b) Bonus. Employee shall also be entitled to a bonus determined at the sole discretion of Company’s Board of Directors.

3. Other Employment Benefits.

(a) Business Expenses. Upon submission of itemized expense statements in the manner specified by the Company, Employee shall be entitled to reimbursement for business - expenses duly incurred by Employee in the performance of his duties under this Agreement.

(b) Benefit Plans. Employee shall be entitled to participate in the Company's medical and dental plans, life and disability insurance plans, and retirement plans pursuant to their terms and conditions. Employee shall be entitled to any other benefit plan of the Company to its employees during the term of this Agreement. Nothing in this Agreement shall preclude the Company from terminating or amending any employee benefit plan or program from time to time.

(c) Vacation. Employee shall be entitled to fifteen (15) days of vacation each year of full employment, exclusive of legal holidays, as long as the scheduling of Employee's vacation does not interfere with the Company's normal business operations.

(d) Holidays. Employee shall be entitled to twelve (12) holidays designated by Company.

4. Confidentiality. Employee agrees to protect Employers confidential information as set out
in the attached Employee Confidentiality Agreement.

5. Termination of Employment

(a) For Cause. Notwithstanding anything herein to the contrary, the Company may terminate Employee’s employment hereunder for cause for any one of the following reasons: (1) conviction of a felony, any act involving moral turpitude, or a misdemeanor where imprisonment is imposed, (2) commission of any act of theft, fraud, dishonesty. or falsification of any employment or Company records, (3) improper disclosure of the Company’s confidential or proprietary information, (4) any action by the Employee that has a detrimental on the Company's reputation or business, (5) Employee’s failure or inability to perform any reasonable assigned duties after written notice the Company of. and a reasonable opportunity to cure, such
 
 
 

 
 
failure or inability, (6) any breach of this Agreement, which breach is not cured within ten (10) days following written notice of such breach, (7) a course of conduct amounting to gloss incompetence. (8) chronic and unexcused absenteeism, (9) unlawful appropriation of a corporate opportunity, or (10) misconduct in connection with the performance of any of Employee’s duties, including, without limitation, misappropriation of funds or property of the Company, securing or attempting to secure personally any profit in connection with any transaction entered into on behalf of the Company, misrepresentation to the Company or any violation of law or regulations on Company premises or to which the Company is subject. Upon termination of Employee's employment with the Company for cause, the Company shall be under no further obligation to Employee, except to pay all accrued but unpaid base salary and accrued vacation to the date of termination thereof.

(b) Without Cause. The Company may terminate Employee's employment hereunder ax any time without cause by unanimous vote of the Board of Directors, provided, however, that Employee shall be entitled to severance pay in the amount of 3 months of Base Salary in addition to accrued but unpaid Base Salary and accrued vacation, less deductions required by law.

6. Intellectual property. All intellectual property (inventions, parents, copyrighted material, secrets, etc.) generated by Employee in the course of work for Company shall be owned solely by Company.

7. This agreement shall be construed in accordance with the statutes of the State of New Mexico, USA.

Caldera Pharmaceuticals, Inc.
Employee
Print Name: Sigmund Eisenschenk
Print Name: Benjamin Warner
[Signed] /Sigmund Eisenschenk/
[Signed] /Benjamin Warner/
Date 10/25/06
Date 10/26/06

Exhibit 10.2
 
Caldera Pharmaceuticals, Inc.
EMPLOYMENT AGREEMENT

Agreement made this 17th day of August, 2006 , between Caldera Pharmaceuticals, Inc., a Delaware corporation (hereinafter referred to as “Company”) and Lori Court , hereinafter referred to as “Employee.”

In consideration of the mutual covenants and agreements hereinafter set forth, the Company and Employee agree as follows:

1.           Term of Employment. The term of employee’s employment shall commence on August 17, 2006  and shall continue until terminated as provided for herein.

(a)            Duties & Responsibilities.   Employee will report directly to the company CEO or to his designate.  Employee will have the responsibilities and duties of Program Manager / Molecular Epidemiologist as well as other duties on behalf of the company as assigned by the CEO.

2.           Compensation.

(a)           Base Salary. Employee shall be paid a base salary ("Base Salary") at the annual rate of $ 100,000 payable in bi-weekly installments consistent with Company’s payroll practices and subject to all applicable employment and withholding taxes.

(b)           Bonus. Employee shall also be entitled to a bonus determined at the sole discretion of Company’s CEO and/or by the Company policies as set by the CEO or the Board of Directors.

3.           Other Employment Benefits.

(a)           Business Expenses. Upon submission of itemized expense statements in the manner specified by the Company, Employee shall be entitled to reimbursement for business expenses duly incurred by Employee in the performance of his duties under this Agreement.

(b)           Benefit Plans. Employee shall be entitled to participate in the Company’s medical and dental plans, life and disability insurance plans, and retirement plans pursuant to their terms and conditions. Employee shall be entitled to participate in any other benefit plan offered by the Company to its employees during the term of this Agreement (other than stock option or stock incentive plans, which are governed by Section 3(d) below). Nothing in this Agreement shall preclude the Company from terminating or amending any employee benefit plan or program from time to time.

(c)   Vacation. Employee shall be entitled to fifteen (15) days of vacation each year of full employment, exclusive of legal holidays, as long as the scheduling of Employee’s vacation does not interfere with the Company’s normal business operations.

(d)   Holidays. Employee shall be entitled to twelve (12) holidays designated by Company.

(e)   Flextime.  The position is salaried and flextime is allowed as long as such activities do not materially affect the employees’ ability to carry out duties to the company.

4.           Confidentiality. Employee agrees to protect Employer’s confidential information as set out in the attached Employee Confidentiality Agreement.

5.           Termination of Employment.
 
 
 

 
 
(a) For Cause. Notwithstanding anything herein to the contrary, the Company may terminate Employee’s employment hereunder for cause for any one of the following reasons: (1) conviction of a felony, any act involving moral turpitude, or a misdemeanor where imprisonment is imposed, (2) commission of any act of theft, fraud, dishonesty, or falsification of any employment or Company records, (3) improper disclosure of the Company’s confidential or proprietary information, (4) any action by the Employee that has a detrimental effect on the Company’s reputation or business, (5) Employee’s failure or inability to perform any reasonable assigned duties after written notice from the Company of, and a reasonable opportunity to cure, such failure or inability, (6) any breach of this Agreement, which breach is not cured within ten (10) days following written notice of such breach, (7) a course of conduct amounting to gross incompetence, (8) chronic and unexcused absenteeism, (9) unlawful appropriation of a corporate opportunity, or (10) misconduct in connection with the performance of any of Employee’s duties, including, without limitation, misappropriation of funds or property of the Company, securing or attempting to secure personally any profit in connection with any transaction entered into on behalf of the Company, misrepresentation to the Company, or any violation of law or regulations on Company premises or to which the Company is subject. Upon termination of Employee’s employment with the Company for cause, the Company shall be under no further obligation to Employee, except to pay all accrued but unpaid base salary and accrued vacation to the date of termination thereof.

(b) Without Cause. The Company may terminate Employee’s employment hereunder at any time without cause, provided, however, that Employee shall be entitled to severance pay in the amount of two weeks of Base Salary per year of employment in addition to accrued but unpaid Base Salary and accrued vacation, less deductions required by law.

6.           Intellectual property. All intellectual property (inventions, patents, copyrighted material, trade secrets, etc.) generated by Employee in the course of work for Company shall be owned solely by Company.

7.           This agreement shall be construed in accordance with the statutes ad legal decision of the State of New Mexico, USA.
 
 
  Caldera Pharmaceuticals   Employee  
             
  Print name      Print name     
             
  [Signed]     [Signed]    
             
  Date     Date     
 
Exhibit 10.3
 
CERTAIN PORTIONS OF THIS EXHIBIT HAVE BEEN OMITTED BASED UPON A REQUEST FOR CONFIDENTIAL TREATMENT WITH THE UNITED STATES SECURITIES AND EXCHANGE COMMISSION.  THE NON-PUBLIC INFORMATION HAS BEEN FILED WITH THE COMMISSION.
 
LANL License Agreement No. 04-COI572
 
 
 
 
 
EXCLUSIVE PATENT LICENSE AGREEMENT
BETWEEN

THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

AND
 
CALDERA PHARMACEUTICALS, INC.
 
 
 
 
 
OFFICIAL USE ONLY
May be exempt from public release under the Freedom of Information Act
(5 U.S.C. 552), exemption number and category:
[Exemption 5, Privileged Information]
 Department of Energy review required before public release
Name/Org: ( Laura Barber, TT Division ), Date: September 23, 2004
Guidance (if applicable) [DOE M 471.3-1]
 
 
1

 
 
TABLE OF CONTENTS
 
I. DEFINITIONS  3
2. GRANT   5
3. SUBLICENSES  5
4. FEES AND ROYALTIES  6
5. DILIGENCE  7
6. PROGRESS REPORTS  8
7. BOOKS AND RECORDS  8
8. TERM OF THE LICENSE AGREEMENT  9
9. TERMINATION BY THE UNNERSITY  9
10. TERMINATION BY THE LICENSEE  10
11. PATENT PROSECUTION, MAINTENANCE AND DISCLAIMER  10
12. USE OF NAMES, TRADENAMES AND TRADEMARKS  11
13. WARRANTY AND DISCLAIMER     12
14. INFRINGEMENT   13
15. WAIVER  14
16. ASSIGNABILITY  14
17. INDEMNIFICATION  14
18. LATE PAYMENTS  15
19. NOTICES  16
20. FORCE MAJEURE  16
21. EXPORT CONTROL LAWS  17
22. PREFERENCE FOR UNITED STATES INDUSTRY  17
23. DISPUTE RESOLUTION    17
24. PATENT MARKING  17
25. GOVERNING LAW   17
26. SURVIVAL  17
27. GOVERNMENT APPROVAL OR REGISTRATION  18
28. DISPOSITION OF LICENSED PRODUCTS AND LICENSED SERVICES  18
29. MISCELLANEOUS    18
APPENDIX A -PATENT RIGHTS    21
APPENDIX B -FEES AND ROYALTIES    23
FEES AND ROYALTIES      23
APPENDIX C -MILESTONES  26
APPENDIX D -REPORT FORMAT  27
APPENDIX E -ROYALTY REPORT FORMAT   28
 
 
2

 
 
EXCLUSIVE PATENT LICENSE AGREEMENT
 
THIS LICENSE AGREEMENT is entered into by and between THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, a nonprofit educational institution and a public corporation of the State of California having its principal office at 1111 Franklin Street, Oakland, CA 94607, hereinafter referred to as the "University," and CALDERA PHARMACEUTICALS, INC., located at 903 Tewa Loop, Los Alamos, NM 87544 and incorporated in the State of Delaware, hereinafter referred to as the "Licensee," the parties to this License Agreement being referred to individually as a "Party," and collectively as "Parties."
 
The University conducts research and development at Los Alamos National Laboratory for the U.S. Government under Contract No. W-7405-ENG-36, hereinafter referred to as the "Contract," with the U.S. Department of Energy, hereinafter referred to as the "DOE."

Rights in inventions and technical data made in the course of the University's research and development at Los Alamos National Laboratory are governed by the terms and conditions of the Contract.
 
Certain TECHNOLOGY related to a Method for Detecting Binding Constants Using Micro X-Ray Fluorescence (MXRF) has been developed in the course of the University's research and development at Los Alamos National Laboratory.
 
The University desires that such TECHNOLOGY be developed and utilized to the fullest extent possible so as to enhance the accrual of economic and technological benefits to the U.S. domestic economy, and is therefore willing to grant an exclusive license to the Licensee in PATENT RIGHTS that protect the TECHNOLOGY.
 
The Licensee desires to obtain from the University certain exclusive rights for the commercial development, manufacture, use, and sale of the TECHINOLOGY.
 
Now, therefore, the Parties agree as follows:
 
1. DEFINITIONS
 
1.1 "TECHNOLOGY" means technical information, know-how, data and PATENT RIGHTS owned or controlled by the University and relating to a Method for Detecting Binding Constants Using Micro X-Ray Fluorescence (MXRF).
 
1.2 "PATENT RIGHTS" means the University’s rights arising from the U.S. and international patents or applications, including any continuing applications, divisionals, and reissues thereof(but not including continuations-in-part), and the patents issuing on applications, identified in Appendix A, incorporated herein by reference.
 
1.3 "LICENSED METHOD(S)" means any method, procedure or process whose use, but for the license granted to the Licensee herein, would constitute an infringement of a subsisting claim of a patent or patent application identified in Appendix A.
 
 
3

 
 
1.4 "LICENSED PRODUCT(S)" means any article of manufacture, machine or composition of matter whose manufacture, importation, use, sale, or offer for sale, but for the license granted to Licensee herein, would constitute an infringement of a subsisting claim of a patent or patent application identified in Appendix A. LICENSED PRODUCTS do not include materials or chemicals developed by use of the method or apparatus claims in the PATENT RIGHTS.
 
1.5 "LICENSED INVENTION(S)" means any LICENSED PRODUCT or LICENSED METHOD.
 
1.6 "LICENSED SERVICE(S)" means services performed for third-party customers on a fee-for-services basis, where the data resulting from such services is provided to the customer for its use, and where the performance of such services would, but for the license rights granted, constitute an infringement of a subsisting claim of a patent or patent application identified in Appendix A herein. To the extent LICENSED SERVICES are performed in combination with other services, earned royalties shall only be based on net sales to the extent attributable to the LICENSED SERVICES, and only if such LICENSED SERVICES are separately invoiced.
 
1.7 "SALES" means disposing of a LICENSED PRODUCT by sale, lease, or other transaction for consideration or practicing LICENSED METHOD or providing a LICENSED SERVICE for consideration. SALES occur when consideration is received for disposition of LICENSED PRODUCT or practice of LICENSED METHOD or LICENSED SERVICE or when LICENSED PRODUCT is invoiced or delivered to a third person, whichever occurs first.
 
1.8 "SALES PRICE" means the cost of LICENSED SERVICE provided, or the invoice prices for SALES or, if LICENSED INVENTIONS are not sold but otherwise disposed of, the selling price at which products of similar kind and quality, sold in similar quantities as LICENSED INVENTIONS, are being offered for sale by the Licensee. Where such LICENSED PRODUCTS or LICENSED SERVICES are not currently being offered for sale by the Licensee, the SALES PRICE for purposes of computing royalties is the average selling price at which products of similar kind and quality, sold in similar quantities, are then currently being offered for sale by other companies. If such products are not currently sold or offered for sale by others, then the SALES PRICE, for purposes of computing royalties, is the Licensee's cost of manufacture determined by the Licensee's customary accounting procedures, plus the Licensee's standard mark-up.
 
1.9 "NET SALES" means the gross amounts for SALES at SALES PRICE by the Licensee and its sublicensee(s), less the following deductions where applicable: (a) SALES returns; (b) normal and customary allowances; (c) trade discounts; (d) SALES to the U.S. Government pursuant to Paragraph 4.2 (e) transportation charges, duties and tariffs only if separately stated on an invoice; but before the deduction of sales and excise taxes, costs of insurance, and agents' commissions; and (f) any sales or similar tax imposed on the buyer but required by law to be collected by the seller and remitted to the taxing authority and any gross receipts or similar tax imposed on or measured by the seller's receipts, but only if passed on to the buyer and separately stated as a tax on the invoice and only to the extent remitted to the taxing authority.
 
 
4

 
 
2. GRANT

2.1 The University grants to Licensee, subject to Paragraphs 2.2 and 2.3, an exclusive License to make, have made, use, import, sell and offer to sell, and have sold LICENSED INVENTIONS and LICENSED SERVICES under the PATENT RIGHTS, with the right to sublicense others under the terms of Article 3.
 
2.2 Rights not expressly granted to the Licensee herein are expressly reserved to the University.
 
2.3 The University expressly reserves the right to use the TECHNOLOGY, including the right to make, have made, use and have used LICENSED INVENTIONS and LICENSED SERVICES for any noncommercial purpose, including, but not limited to, Cooperative Research and Development Agreements, Work for Others Agreements, and User Facility Agreements.
 
2.4 The U.S. Government has a nonexclusive, nontransferable, irrevocable, paid-up license to practice or have practiced throughout the world, for or on behalf of the U.S. Government; inventions covered by the University's PATENT RIGHTS, and has certain other rights under 35 U.S.C. 200-212 and applicable implementing regulations.
 
2.5 Under 35 U.S.C. 203 the U.S. Department of Energy has the right to require the Licensee to grant a nonexclusive, partially exclusive or exclusive license under the PATENT RI GHTS in any field-of-use to a responsible applicant or applicants in accordance with 48 CFR 27.304-1 (g).
 
2.6 The Licensee will make available to the University and will grant an irrevocable, paid-Up, royalty-free nonexclusive license to the University to make, have made, use, and have used for any purpose permitted under the Contract any improvements or developments to the TECHNOLOGY made by the Licensee. Such improvements can be used for any U.S. Government or non-commercial purpose and the University does not have the right to sublicense such improvements for any commercial purpose.
 
3. SUBLICENSES
 
3.1 The University grants to the Licensee the right to grant sublicenses to third parties to make, use, import, sell and offer to sell LICENSED INVENTIONS and LICENSED SERVICES in which the Licensee has current exclusive rights under this License Agreement.
 
3.2 Sublicenses granted under this clause must contain all of the conditions, restrictions and reservations of this License Agreement, except for loose provisions related to fees, and royalties, and must preserve the rights and reservations of the University and the U.S. Government existing under this License Agreement.
 
3.3 The Licensee must provide the University with a copy of each sublicense within thirty (30) days after its execution.
 
 
5

 
 
3.4. The Licensee must pay to the University the payments prescribed in Appendix B. With respect to any sublicense, this obligation continues as long as a sublicense granted by the Licensee is in effect, and is an obligation of the Licensee whether or not royalty payments are actually received by the Licensee from its sublicensee(s).
 
3.5 The Licensee must deliver to the University copies of all progress and royalty reports delivered to the Licensee by the Licensee's sublicensee(s). With respect to any sublicense, this obligation continues as long as a sublicense granted by the Licensee is in effect.
 
3.6 Termination of this License Agreement by the Licensee automatically operates as an assignment by the Licensee to tile University of all Licensee's right, title and interest in and to each sublicense granted by the Licensee. If this License Agreement is terminated by either Party, any sublicensee(s) not in default of the terms and conditions or its sublicense agreement with the Licensee must make a written election to the University to continue such sublicense agreement as a license agreement with the University. The Licensee will give its sublicensee(s) written notice thirty (30) days prior to effective date of termination of this License Agreement. Sublicensee(s) must make such written election to the University within thirty (30) days thereafter. The University's obligations under any assigned sublicense are limited only to the University's obligations under this License Agreement.
 
4. FEES, ROYALTIES AND SHAREHOLDER EQUITY
 
4.1 In consideration for the rights, privileges and license granted under this License Agreement, the Licensee must pay to the University the fees, royalties, and equity payments specified in Appendix B, incorporated herein by reference. The acceptance of Licensee's common stock is subject to the final approval of the Office of the President of the University of California, and, in the event that such an approval is not granted, this Agreement shall remain in effect and Licensee and the University shall re-negotiate in good faith for a substitution of similar value for consideration. However, if such re-negotiations fail to produce a mutually agreeable substitution for the common stock within ninety (90) days of the date such negotiations commence, the Licensee will, within thirty (30) days thereafter, pay the University a cash payment equal to the value of the common stock calculated using the highest cost per share at which the common stock has previously been issued, failing which the University may immediately terminate this License Agreement without recourse to the notification procedure specified in Article 9.
 
4.2 Notwithstanding Paragraph 4.1 above, the Licensee has no obligation to pay royalties on any SALES of any LICENSED INVENTION or provision of LICENSED SERVICES to the U.S. Government or any agency thereof or any U.S. Government contractor that certifies that its purchase of the LICENSED INVENTION or LICENSED SERVICE is for or on behalf of the U.S. Government. The Licensee must not impose royalty charges on SALES of LICENSED INVENTION or LICENSED SERVICES to U.S. Government entities, and must refund to them any royalty collected on such SALES.
 
 
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4.3 Royalty payments are to be calculated based on NET SALES during the quarterly periods extending from January 1 through March 31 (first quarter), April 1 through June 30 (second quarter), July 1 through September 30 (third quarter), and from October 1 through December 31 (fourth quarter) of each year, for as long as this License Agreement remains in effect. The first royalty payment due under this License Agreement is based on NET SALES from the effective date of this License Agreement to the end of the quarterly period which includes such effective date. Subsequent royalty payments are due concurrently with the Royalty Reports, pursuant to Paragraph 6.2, on the following dates:
 
  May 31 for the calendar quarter beginning January 1 and ending March 31.
 
  August 31 for the calendar quarter beginning April 1 and ending June 30.
 
  November 30 for the calendar quarter beginning July 1 and ending September 30.
 
  February 28 for the calendar quarter beginning October 1 and ending December 31.

4.4 All payments due the University must be paid in U.S. currency to the University, at the address set forth in Paragraph 19. The Licensee must convert NET SALES invoiced in foreign currency into equivalent U.S. currency at the exchange rate for the foreign currency prevailing as of the last day of the reporting period, as reported in the Wall Street Journal®.
 
4.5 The Licensee will not be required to pay a royalty on its own internal use of the PATENT RIGHTS, or on sales of Therapeutics and Diagnostics identified, discovered, researched or developed (internally or for third parties as LICENSED SERVICES) through the practice of the PATENT RIGHTS.
 
4.6 The Licensee will not be required t0 pay royalties from sales of LICENSED PRODUCTS where such LICENSED PRODUCTS are manufactured and sold in countries in which the University does not have patent protection.
 
5. DILIGENCE
 
5.1 The Licensee will use its best efforts to bring one or more LICENSED INVENTIONS to market through a thorough, vigorous and diligent program for exploitation of the PATENT RIGHTS and to continue active, diligent marketing efforts for LICENSED INVENTIONS and LICENSED SERVICES throughout the life of this License Agreement.
 
5.2 To be in compliance with Paragraph 5.1, the Licensee must meet the Commercialization Milestones set out in Appendix C, incorporated herein by reference.
 
5.3 Article 5 is a material term of this Agreement, without which the license grant under Article 2 would not have been made, and the Licensee's failure to perform in accordance with Paragraphs 5.1 and 5.2 is grounds for the University to terminate this License Agreement pursuant to Paragraph 9.1.
 
 
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6. REPORTS
 
6.1 Progress Reports. The Licensee will submit to the University a semi-annual progress report covering activities by the Licensee related to the development and testing of all LICENSED INVENTIONS and the provision of LICENSED SERVICES and obtaining government approvals necessary for marketing them. These progress reports will be provided to the University to cover the progress of the research, development and commercialization activities, until NET SALES exceed Ten Million Dollars ($10,000,000). Progress reports shall comply with the report Format shown in Appendix D. Reports marked by the Licensee as proprietary financial or business information of the Licensee will be treated by the University as proprietary information.
 
Progress reports are due on the following dates:
 
  August 31 for the calendar half beginning January 1 and ending June 30.
 
  February 28 for the calendar half beginning July 1 and ending December 31.

6.2 Royalty Reports. The Licensee must submit quarterly royalty reports. Royalty reports shall comply with the report format shown in Appendix E. Reports marked by the Licensee as proprietary financial or business information of the Licensee will be treated by the University as proprietary information.
 
IF NO SALE, SUBLICENSE OR USE or LICENSED INVENTION OR PROVISION OF LICENSED SERVICES HAS BEEN MADE DURING A REPORTING PERIOD, A STATEMENT TO THIS EFFECT MUST BE SENT TO THE UNIVERSITY.
 
Royalty reports are due on the following dates:
 
  May 31 for the calendar quarter beginning January 1 and ending March 31.
 
  August 31 for the calendar quarter beginning April 1 and ending June 30.
 
  November 30 for the calendar quarter beginning July 1 and ending September 30.
 
  February 28 for the calendar quarter beginning October 1 and ending December 31.

7. BOOKS AND RECORDS
 
7.1 The Licensee must keep books and records according to Generally Accepted Accounting Principles, accurately showing all activities related to commercializing LICENSED INVENTIONS and providing LICENSED SERVICES by the Licensee and its sublicensee(s) under the terms of this License Agreement. Such books and records must be open to inspection and audit on a proprietary basis by representatives or agents of the University at reasonable times, but in no event more than once for each calendar year, for the purpose of verifying the accuracy of the royalty and progress reports and the royalties due. The Licensee may request that any such inspection and audit be conducted by an independent auditor, in which event the Licensee will pay the costs of the auditor.
 
 
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7.2 The fees and expenses of the University's representatives performing the inspection and audit will be borne by the University. However, if the audit discloses an error in royalties owed the University of more than Ten percent (10%) of royalties paid to the University, then the Licensee will pay the fees and expenses of said representatives within thirty (30) days after receipt of invoice.
 
7.3 The Licensee's books and records related to LICENSED INVENTIONS and LICENSED SERVICES must be preserved for at least five (5) years from the last date that the royalty payments were made.
 
8. TERM OF THE LICENSE AGREEMENT
 
8.1 This License Agreement will be effective upon execution by the Parties and the University's receipt of the License Issue Fee specified in Appendix B.
 
8.2 This License Agreement is in full force and effect from the effective date and remains in effect until the expiration of the last to expire of the patents included within the University's PATENT RIGHTS, unless sooner terminated by operation of law or by acts of either of the Parties in accordance with the terms of this License Agreement.
 
9. TERMINATION BY THE UNIVERSITY
 
9.1 If the Licensee fails to deliver to the University any report when due, or fails to pay any royalty or fee when due, or if the Licensee breaches any other material term of this Lice.nse Agreement, including, but not limited to, Article 5, DILIGENCE, the University may give written notice of default to the Licensee.  If the Licensee fails to cure the default within sixty (60) days from the date of delivery of the notice of default to the Licensee, the University has the right to terminate this License Agreement. This License Agreement will terminate upon delivery of written notice of termination to the Licensee. Termination does not relieve the Licensee of its obligation to pay any royalty or license fees due or owing at the time of termination and does not impair any accrued right of the University.
 
9.2 The Licensee must provide notice to the University of its intention to file a voluntary petition in bankruptcy or, where known to the Licensee, of another party's intention to file an involuntary petition in bankruptcy for the Licensee, said notice must be received by the University at least thirty (30) days prior to filing such petition. The University may terminate this License Agreement upon receipt of such notice at its sole discretion. The Licensee's failure to provide such notice to the University will be deemed a material, pre-petition, incurable breach or this License Agreement and the License Agreement will terminate automatically on the date of filing such voluntary or involuntary petition in bankruptcy.
 
 
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10. TERMINATION BY THE LICENSEE
 
10.1 The Licensee may terminate this License Agreement by giving written notice to the University. Such termination will be effective ninety (90) days from the date of delivery of the notice, and all the Licensee's rights under this License Agreement will cease as of that date.
 
10.2 Termination pursuant to this Article does not relieve the Licensee of any obligation or liability accrued by the Licensee prior to the effective date of termination or affect any rights of the University arising under this License Agreement prior to termination.
 
11. PATENT PROSECUTION, MAINTENANCE AND DISCLAIMER
 
11.1 The University will prosecute U.S. patent applications identified in Appendix A in the U.S. Patent and Trademark Office (USPTO), and will maintain U.S. patents identified in Appendix A, using counsel of its choice. The University will provide the Licensee, upon the Licensee's written request, with copies of relevant documentation relating to any such patent prosecution. The Licensee will hold such documentation in confidence in the same manner as if it were the Licensee's financial or business information or trade secrets.
 
11.2 The University may amend U.S. patent applications identified in Appendix A to include reasonable claims requested by the Licensee if such claims are required to protect commercial applications of the LICENSED INVENTION. Requested amendments will be introduced into the patent applications at the sole discretion of the University.
 
11.3 The Licensee understands and agrees that the prosecution of patent applications is uncertain and that certain claims therein may not be allowed or may receive narrower breadth of scope than when originally filed and that patent applications may not issue as a U.S. patent. Therefore, the University provides no representation or warranty that any of the patent applications identified in Appendix A will issue as a U.S. patent or that the scope of claims coverage of any resulting patent issuing thereon will have the same scope of claims coverage as when filed by the University or when reviewed by the Licensee.
 
11.4 The University agrees to provide written notification to the Licensee if any of the patent applications identified in Appendix A receive a final rejection, and further agrees to review recommendations from the Licensee and/or the Licensee's patent attorneys as to how to further the University's prosecution efforts in the USPTO. However, it will be at the University's sole discretion whether the University implements the prosecution advice of the Licensee and/or the Licensee's patent attorneys.
 
11.5 The University agrees to provide written notification to the Licensee if the University intends to terminate prosecution of any of the U.S. patent applications identified in Appendix A. Acceptance by the University of allowed claims in any of the U.S. patent applications and allowing the U.S. patent applications to proceed to issuance with these claims, or abandonment of any of the U.S. patent applications will be at the sole discretion of the University.  If the University elects to terminate prosecution of a U.S. patent application for a reason other than to accept allowed claims, the Licensee may elect in writing to assume responsibility for such prosecution in the name of the University at its own expense.
 
 
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11.6 The costs associated with U.S. and Patent Cooperation Treaty (PCT) cases will be borne by the University. The costs associated with international cases will be borne by the Licensee for each national case identified in Appendix A.
 
11.7 The Licensee must take the following actions to obtain and maintain international rights:
 
  The Licensee must diligently pursue, at the Licensee' s expense, in the name of the University and assigned to the University, the filing, prosecution, and maintenance of all international patent applications and patents listed in Appendix A using counsel of the Licensee's choice.

  The Licensee may request amendments to Appendix A, Foreign Patent Rights, in writing to the University, provided such requests are made at least ninety (90) days before any action on the cases affected by the requested amendment is due.

  The Licensee must provide the University with a copy of all foreign filing actions, including a copy of official records, correspondence, costs of such actions (including attorney's fees, filing fees, and translation expenses), and a cumulative sum of such costs to date, within thirty (30) business days from the date such action is taken by or received by the Licensee.

11.8 The obligation of the Licensee to prosecute and pay for costs of international patents and patent applications under this Article continues as long as this License Agreement remains in effect irrespective of when invoiced by the Licensee's foreign associates. The Licensee may terminate such prosecution and obligations with respect to any foreign case by giving ninety (90) days written notice to the University. The University may at its election continue prosecution of maintenance of such cases at the expense of the University and the Licensee will have no further right or license thereunder.
 
11.9 The failure of the Licensee to include countries in Appendix A for international patent rights will be considered an election by the Licensee not to secure such rights. The University has the right to seek such patent rights in any country for which a patent application has not been filed as of the effective date of this Agreement and for which the Licensee has declined international rights and may seek additional licensees of such rights.
 
12. USE OF NAMES, TRADENAMES AND TRADEMARKS AND NONDISCLOSURE OF AGREEMENT TERMS

12.1 Nothing contained in this License Agreement confers any right to use in advertising, publicity, or order promotional activities any name, tradename, trademark, or other designation of either Party hereto or the Department of Energy or Los Alamos National Laboratory (including any contraction, abbreviation, or simulation of any of the foregoing). Unless required by law, the use of the name "University of California," "The Regents of the University of California," or the name of any facility or campus of the University of California is expressly prohibited.
 
 
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12.2 The University may disclose to third parties the existence of this License Agreement and the extent of the grant in Article 2, but will not disclose information identified as proprietary by the Licensee herein, if any, except where the University is required to release information under either the California Public Records Act or other applicable law. A decision to release information under applicable law will be at the sole discretion of the University.
 
12.3 The Licensee may disclose to third parties the existence of this License Agreement and the terms and conditions to the extent determined appropriate by the Licensee.
 
12.4 The University acknowledges that the Licensee considers Appendices B and C of this License Agreement to contain proprietary business information of the Licensee and Appendices B and C are marked as such. All other portions of this License Agreement are non­proprietary.
 
13. WARRANTY AND DISCLAIMER
 
l3.1 The University warrants that it is the lawful owner of the PATENT RIGHTS listed in Paragraph 1.2.
 
THE TECHNOLOGY IS PROVIDED AS IS WITHOUT WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE OR ANY OTHER WARRANTY, EXPRESS OR IMPLIED. NEITHER THE UNIVERSITY NOR THE U.S. GOVERNMENT MAKES ANY REPRESENTATION OR WARRANTY THAT THE LICENSED PRODUCTS, LICENSED METHODS, OR LICENSED SERVICES WILL NOT INFRINGE ANY PATENT OR OTHER PROPRIETARY RIGHT. IN NO EVENT WILL THE UNIVERSITY OR THE U.S. GOVERNMENT BE LIABLE FOR ANY INCIDENTAL, SPECIAL, OR CONSEQUENTIAL DAMAGES RESULTING FROM EXERCISE OF THIS LICENSE OR THE USE OF LICENSED PRODUCTS OR LICENSED METHODS OR PROVISION OF LICENSED SERVICES.

13.2 Nothing in this License Agreement will be construed as:
 
a. a warranty or representation by the University or the U.S. Government as to the validity or scope of the University's PATENT RIGHT;
 
b. an obligation to bring or prosecute actions or suits against third parties for patent infringement, except as provided in Article 14;
 
c. conferring by implication, estoppel, or otherwise any license or rights under any patents of the University or the U. S. Government other than the University's PATENT RIGHTS; or

d. an obligation by the University or the U.S. Government to furnish any know-how, technical assistance, or technical data other than as stated in Article 2 above.
 
13.3 NEITHER THE UNITED STATES NOR THE UNITED STATES DEPARTMENT OF ENERGY, NOR THE UNIVERSITY NOR ANY OF THEIR EMPLOYEES, AGENTS OR CONTRACTORS MAKES ANY WARRANTY, EXPRESS OR IMPLIED, OR ASSUMES ANY LEGAL LIABILITY OR RESPONSIBILITY FOR THE ACCURACY, COMPLETENESS, OR USEFULNESS OF ANY SOFTWARE, INFORMATION, APPARATUS, PRODUCT, OR PROCESS DISCLOSED, OR REPRESENTS THAT ITS USE WOULD NOT INFRINGE PRIVATELY OWNED RIGHTS.
 
 
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14.  INFRINGEMENT
 
14.1 In the event that the Licensee learns of the substantial infringement of any PATENT RIGHTS under this License Agreement, the Licensee will notify the University in writing and will provide the University with reasonable evidence of such infringement. The Licensee will not notify a third party of the infringement of any PATENT RIGHTS without first obtaining consent of the University, which consent will not be unreasonably withheld. The Parties will use their best efforts in cooperation with each other to terminate such infringement without litigation.
 
14.2 If the Licensee desires that PATENT RIGHTS be enforced against infringers, the Licensee may request permission from the University to file suit against the infringement of PATENT RIGHTS or may request that the University take legal action against the infringement of PATENT RIGHTS. Such request must be made in writing and must include reasonable evidence of such infringement and damages to the Licensee. If the infringing activity has not been abated within ninety (90) days following the receipt of such request, the University will have the right to elect to
 
a. commence suit on its own account;
b. commence suit jointly with the Licensee; or
c. refuse to participate in such suit.

The University will give notice of its election in writing to the Licensee by the end of the 10th day after receiving such request from the Licensee. The Licensee may thereafter bring suit for patent infringement if and only if the University elects not to commence suit and if the infringement occurred during the period and in a jurisdiction where the Licensee had exclusive rights under this License Agreement. In the event, however, the Licensee elects to bring suit in accordance with this Paragraph, the University may thereafter join such suit at its own expense. Both parties agree to be bound by the outcome of a suit for patent infringement through the pendency of such a suit under this Paragraph.
 
14.3 Any legal action under this Article will be at the expense of the Party initiating the legal action. The Licensee will bear all expenses of any action brought by the Licensee under this Article, including attorney fees and costs of both Parties in the defense of any declaratory judgment actions or counter-claims brought by the infringer. If legal action is brought by the Licensee, the University is entitled to twenty-five percent (25%) of any damage recovery based on lost profits of the Licensee or a reasonable royalty. Legal action brought jointly by the University and the Licensee and fully participated in by both will be at the joint expense of the Parties and all recoveries will be shared jointly by them in proportion to the share of expenses paid by each.
 
 
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14.4 Each Party will cooperate with the other in proceedings instituted hereunder, provided expenses arc borne by the Party bringing suit. Litigation will be controlled by the Party bringing suit, except that the University will control the litigation if brought jointly. The University may be represented by its choice of counsel in any suit brought by the Licensee.
 
14.5 Neither Party will settle or compromise any suit without the other Party's written consent.
 
15. WAIVER
 
15.1 No waiver by either Party of any breach or default of any of the covenants or terms of this License Agreement will be deemed a waiver as to any prior, subsequent and/or similar breach or default.
 
16. ASSIGNMENT AND CONTROLLING INTEREST
 
16.1 This License Agreement may be assigned by the University, but is personal to the Licensee and assignable by the Licensee only with the prior written consent of the University, which will not be withheld unreasonably.
 
16.2 In the event that a controlling interest in the Licensee is obtained by an entity different than the entity having a controlling interest on the effective date of this License Agreement, the University may terminate this License Agreement at its discretion, which discretion will not be exercised unreasonably. The Licensee will notify the University ninety (90) days prior to any such change in controlling interest.

17. INDEMNIFICATION
 
17.1 The Licensee will, and will require its sublicensee(s) to indemnify, hold harmless and defend the University and the U.S. Government, their officers, employees, and agents; the sponsors of the research that led to the TECHNOLOGY; the inventors of any invention covered by patents or patent applications in PATENT RIGHTS (including the LICENSED PRODUCT LICENSED METHOD, and LICENSED SERVICES contemplated thereunder); and their employers against any and all claims, suits, losses, damage, costs, fees, and expenses resulting from or arising out of exercise of this license or any sublicense.  This indemnification will include, but will not be limited to, any product liability.
 
17.2 The Licensee, at its sole cost and expense, will insure its activities in connection with the work under this License Agreement and obtain, keep in force, and maintain insurance or an equivalent program of self insurance as follows:
 
a. Comprehensive or Commercial Form General Liability Insurance (contractual liability included) with limits as follows:
 
Each Occurrence $5,000,000 Products/Completed Operations Aggregate $5,000,000 Personal and Advertising Injury $5,000,000 General Aggregate (commercial form only) $5,000,000
 
 
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b. It should be expressly understood, however, that the coverages and limits referred to under the above will not in any way limit the liability of the Licensee. Within thirty (30) days of receiving a written request from the University, the Licensee will furnish the University with certificates of insurance or evidence of self-insurance documenting compliance with all requirements. Such certificates will:
 
i. Provide for 30 day advance written notice to the University of any modification;
 
ii. Indicate that the University has been endorsed as an additional insured under the coverages referred to under the above; and
 
iii. Include a provision that the coverages will be primary and will not participate with or be excess over any valid and collectable insurance or program of self-insurance carried or maintained by the University.
 
17.3 The University will promptly notify the Licensee in writing of any claim or suit brought against the University or the U.S. Government in respect of which the University or the U.S. Government intend to invoke the provisions of this Article. The Licensee will keep the University informed on a current basis of its defense of any claims pursuant to this Article.
 
18. LATE PAYMENTS
 
18.1  In the event royalty payments or fees are not received by the University when due, the Licensee will pay to the University the amount due plus simple interest calculated at the rate of 0.83 percent (0.83%) per month from the date the payment or fee was due to the date payment is actually made.
 
19. NOTICES
 
19.1 Any notice or payment required to be given to either Party will be deemed to have been properly given and to be effective on the date of
 
a.           delivery, if delivered in person;
 
b.           mailing, if mailed by first-class certified mail;
 
c.           mailing, if mailed by any express carrier service that requires the recipient to sign the documents demonstrating the delivery of such notice or payment; or
 
d.           transmission by facsimile with confirmation of transmission
 

to the respective addresses given below:
 
 
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In the case of the Licensee:
 
Caldera Pharmaceuticals, Inc.
903 Tewa Loop
Los Alamos, NM 87544
Attention: Benjamin P. Warner
Telephone: (505) 412-2345
Email address: wamer@alwll.mit.edu

In the case of the University:
Los Alamos National Laboratory
Technology Transfer Division
P.O. Box 1663, Mail Stop C334
Los Alamos, New Mexico 87545
Attention: License Compliance Officer
Telephone: (505) 665-9091
Facsimile: (505) 665-0154 or (505) 665-6 127
 
For Courier Service to the University:
 
Los Alamos National Laboratory
Technology Transfer Division
Bikini Atoll Road, Bldg. SM-30
Los Alamos, NM 87545
Attention: License Compliance Officer
Telephone: (505) 665-9091

For payments due the University:
Los Alamos National Laboratory
Technology Transfer Division
P.O. Box 462
Los Alamos, NM 87544
Attention: License Compliance Officer


20. FORCE MAJEURE
 
20.1 Neither Party is responsible for delay or failure in performance of any of the obligations imposed by this License Agreement if the failure is caused by fire, flood, explosion, lightning, windstorm, earthquake, subsidence of soil, court order or government interference, civil commotion, riot, war, or by any cause of like or unlike nature beyond the control and without fault or negligence or either Party.


21. EXPORT CONTROL LAWS

21.1 Licensee acknowledges and understands that the export of commodities and/or related technical data from the United States may require an export license from the Bureau of Export Administration, and that failure to obtain such export license may result in criminal liability under federal law. Failure of Licensee to comply with this requirement is a material breach of this Agreement for which the University has tile right to terminate this Agreement pursuant to paragraph 9. 1.
 
 
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22. PREFERENCE FOR UNITED STATES INDUSTRY
 
22.1 LICENSED PRODUCTS or products produced through the use of LICENED METHOD sold in the United States must be manufactured substantially in the United States.
 
23. DISPUTE RESOLUTION
 
23.1 The individuals designated in Paragraph 19 agree to exert their best efforts to resolve disputes arising from this License Agreement. In the event that any claim or controversy arising out of this License Agreement cannot be resolved by the aforestated individuals or their successors, such matter will immediately be referred jointly to the respective management of each Party who will meet and undertake to resolve the matter. In the event these individuals fail to resolve the matter within sixty (60) days of referral of the matter to them, either Party may give the other Party notice of its intention to seek other recourse.
 
24. PATENT MARKING
 
24.1 The Licensee agrees to mark, in accordance with the applicable patent marking statute, all LICENSED PRODUCTS, and their containers, which have been made, used, sold or otherwise transferred to a third party, under the terms of this License Agreement.
 
25. GOVERNING LAW
 
25.1 THIS AGREEMENT WILL BE INTERPRETED AND CONSTRUED IN ACCORDANCE WITH THE LAWS OF THE STATE OF CALIFORNIA, excluding any choice of law rules that would direct the application of the laws of another jurisdiction.
 
26. SURVIVAL
 
26.1 When this License Agreement expires or is terminated in accordance with the terms hereof, the following Articles will survive any expiration or termination:
 
Article 1                      DEFINITIONS
Article 3                      SUBLICENSES
Article 7                      BOOKS AND RECORDS
Article 11                      PATENT PROSECUTION, MAINTENANCE AND DISCLAIMER
Article 12                      USE OF NAMES, TRADENAMES, AND TRADEMARKS
Article 13                      WARRANTY AND DISCLAIMER
 
 
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Article 17                      INDEMNIFICATION
Article 18                      LATE PAYMENTS
Article 26                      SURVIVAL
 
27. GOVERNMENT APPROVAL OR REGISTRATION
 
27.1 If this License Agreement or any associated transaction is required by the law of any nation to be either approved, permitted or registered with any governmental agency, the Licensee will assume all legal obligations to do so. The Licensee will notify the University if the Licensee becomes aware that this License Agreement is subject to a U.S. or foreign government reporting, permitting, or approval requirement. The Licensee will make all necessary finings and pay all costs including fees, penalties and all other out-of-pocket costs associated with such reporting, permitting or approval process.
 
28. DISPOSITION OF LICENSED PRODUCTS ON HAND UPON TERMINATlON

28.1 Upon termination of this License Agreement, the Licensee will have the privilege of selling all previously made or partially made LICENSED PRODUCTS and completing all previously commenced LICENSED SERVICES, but no more, within a period of 120 days. The sale of such LICENSED PRODUCTS and LICENSED SERVICES will be subject to the terms of this License Agreement including, but not limited to, the payment of royalties based on the NET SALES of LICENSED PRODUCTS and LICENSED SERVICE at the rates and at the times provided herein and the rendering of reports in connection therewith.
 
29. MISCELLANEOUS
 
29.1 The headings of the several sections of this License Agreement are included for convenience of reference only and are not intended to be a part of or to affect the meaning or interpretation of this License Agreement.
 
29.2 No amendment or modification of this License Agreement is binding on the Parties unless made in a writing executed by duly authorized representatives of the Parties.
 
29.3 This License Agreement, with the attached Appendices, embodies the entire understanding of the Parties and supersedes all previous communications, representations, or understandings, either oral or written, between the parties relating to this License Agreement.
 
29.4 In the event anyone or more of the provisions of this License Agreement is held to be invalid, illegal, or unenforceable in any respect, the invalidity, illegality, or unenforceability will not affect any other provisions hereof, and this License Agreement will be construed as if such invalid or illegal or unenforceable provisions had never been part of this License Agreement.
 
29.5 This License Agreement has been negotiated and prepared jointly by both Parties and shall not be construed for or against any Party.
 
 
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IN WITNESS WHEREOF, both the University and the Licensee have executed this License Agreement, in duplicate originals, by their respective officers on the day and year hereinafter written.
 
 
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA  
     
By:
/s/  Duncan W. McBranch  
  Duncan W. McBranch, Division Leader  
  Technology, Transfer Division  
     
Date: 9/6/ 05  
     
     
CALDERA PHARMACEUTICALS, INC.  
     
By:  /s/    
Printed Name:  Benjamin Peter Warner  
Title: CEO   
     
Date: 9/8 / 05  
     

 
 
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APPENDIX A
 
PATENT RIGHTS
I. U.S. Patent Rights
 
a. DOE S-94,661 -   "Method for Detecting Binding Events Using Micro X-Ray Fluorescence Spectrometry," Benjamin P. Warner et al., U.S. Patent Application No. 09/859,701, filed May 16, 2001.
 
b. DOE S-99,911 -   "Flow Method and Apparatus for Screening Chemicals Using Micro X-Ray Fluorescence," George J. Havrilla et al., U.S. Patent Application No. 10/206,524, filed July 25, 2002.
 
c. DOE S-l00, 585 -  "Method and Apparatus for Detecting Chemical Binding," Benjamin P. Warner et al., U.S. Patent Application No. 10/62 1,825, filed July 16, 2003.
 
d. DOE S-102,376 -   "Drug Development and Manufacturing," Benjamin P. Warner et al., U.S. Patent Application No. 10/880,388, filed June 29, 2004.

2. International Patent Rights
 
a. DOE S-94,661 -   "Method for Detecting Binding Events Using Micro X-Ray Fluorescence Spectrometry," Benjamin P. Warner et al., U.S. Patent Application No. 09/859,701, filed May 16, 2001I. International Patent protection is not available for this case.
 
b. DOE S-99,91J - "Flow Method and Apparatus for Screening Chemicals Using Micro X-Ray Fluorescence," George J. Havrilla et al., U.S. Patent Application No. 101206,524, filed July 25,2002. PCT Application 03/20 103 was filed on June 24, 2003. The Licensee elects international patent prosecution in the following countries:

Country
Application No.
Filing Date
Japan
   
European Patent Office
   
     
 
 
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c. DOE S-J 00, 585 -  "Method and Apparatus for Detecting Chemical Binding," Benjamin P. Warner et. al., U.S. Patent Application No. 10/621,825, filed July 16, 2003. PCT Application 04119678 was filed on June 16, 2004. The Licensee elects international patent prosecution in the following countries:

Country
Application No.
Filing Date
Japan
   
European Patent Office
   
     


 
d. DOE S-1O2,376 -  "Drug Development and Manufacturing," Benjamin P. Warner et al., U.S. Patent Application No. 10/880,388, filed June 29, 2004. A PCT Application may be filed on or before July 16, 2005. The Licensee elects international patent prosecution in the following countries:
 
Country
Application No.
Filing Date
Japan
   
European Patent Office
   
     
 
 
21

 
 
APPENDIX B FEES AND ROYALTIES

 
 
I. Fees
 
a. A non-refundable License Issue Fee of Forty thousand U.S. Dollars ($40,000.00), to be paid upon execution of the License Agreement.
 
b. Annual License Fees, as cash payments, are due and payable according to the following schedule:
 
February 28, 2006
$25,000.00
February 28, 20 15
$50,000.00
February 28, 2007
$25,000.00
February 28, 20 16
$50,000.00
February 28, 2008
$25,000.00
February 28, 2017
$50,000.00
February 28, 2009
$25,000.00
February 28, 20 18
$50,000.00
February 28, 2010
$25,000.00
February 28, 20 19
$50,000.00
February 28 , 20 II
$50,000.00
February 28, 2020
$50,000.00
February 28, 2012
$50,000.00
February 28, 202 1
$50,000.00
February 28, 20 13
$50,000.00
February 28, 2022
$50,000.00
February 28, 20 14
$50,000.00
   

The University will credit the Annual License Fee for a particular calendar year against any royalties earned during that same year. After the royalties accumulated during a given year equals the Annual License Fee previously paid to the University on February 28 th of that same year, Licensee shall consider such credit as having been fully applied and shall pay actual royalties earned for the remainder of that same calendar year.

XXXX
 

 
 
XXXX - redacted pursuant to a confidentiality request with the United States Securities and Exchange Commission
 
 
22

 
 
d. Patent Issue Fees of Twenty thousand U.S. Dollars ($20,000.00) per issuance of each U.S. Patent listed in Appendix A (PATENT RIGHTS), payable to the University within thirty (30) days after receiving official notice from the University regarding the issuance of each U.S. patent.

2. Royalties
 
The Licensee will pay the University a royalty of two percent (2.0%) of NET SALES during the term of this License Agreement.
 
Licensee's sublicensees will pay the University a royalty of two percent (2.0%) of NET SALES during the term of this License Agreement.

3. Shareholder Equity

a. As partial consideration for this Agreement, Licensee will issue to The Regents of the University California ("University") shares of Founders Stock, equivalent in value to three percent (3.0%) of the outstanding common shares of Caldera Pharmaceuticals Inc.'s Founders Stock available as of the effective date of this License Agreement. Such shares shall be convertible to publicly tradable shares in the event that Caldera Pharmaceuticals, Inc. completes an Initial Public Offering. Final acceptance by the University of said equity is conditioned upon receipt and acceptance of any Licensee shareholders' agreement and other relevant information the University deems necessary in order to make a properly informed decision in accordance with the University's applicable guidelines for accepting equity in University technology licensing transactions. Upon final acceptance of said equity, the University reserves the right and sole discretion to direct Licensee to distribute the University's inventors' shares directly to the respective inventors or to the University's Office of the Treasurer that is responsible for managing University equity transactions.
 
b. From and after the effective date of this Agreement, Licensee agrees that University shall be entitled to all rights of a holder of common stock in Licensee, protected from dilution to the same extent that each other holder of shares as of the effective date (referred to for convenience as a "founder") is protected from dilution and shall suffer no greater dilution than any other founder who holds common stock of the Licensee. Licensee further agrees that the relative proportionate ownership of the University shall not be diluted to less than three percent (3.0%) of the total
Number of outstanding shares until such time as Caldera Pharmaceuticals, Inc.
completes an aggregate of $20 million of equity (funds-in) financing.
 
XXXX
 
XXXX - redacted pursuant to a confidentiality request with the United States Securities and Exchange Commission
 
 
23

 
 
APPENDIX C
 
COMMERCIALIZATION MILESTONES
 
 


XXXX








 



XXXX - redacted pursuant to a confidentiality request with the United States Securities and Exchange Commission
 
 
24

 
 
APPENDIX D
 
PROGRESS REPORT FORMAT
 
Date of Report        
Reporting Period: [ ]  January 1 – June 30    
  [ ]  July 1 – December 31    
 
I. Development:
 
  Progress towards commercialization and milestones (Appendix C)
  Problems encountered
  Pre-commercialization marketing efforts
  Any shift in time-line from original business plan
  Expected launch date
  Any improvements, new patents, derivative works, etc. arising from the work

2. Commercialization:
 
  First commercial sale in the U.S.
  First commercial sale outside the U.S.
  Sales, production, provision of Licensed Services or other royalty-generating activity
  Royalty calculations and royalties due

3. Continuing:
 
  Continued efforts in evolving the product/service
  Improvements
  Sublicenses
  Foreign registrations, licenses, commercialization, etc.
  Any problems which would potentially effect the License Agreement
  Any infringements of intellectual properly (as provided in the License Agreement)
  Any potential litigation involving the licensed intellectual property

4. Of General Interest:
 
  Promotional material, news releases, etc.
  Company annual reports
  Testing activity, scientific publications
  Any feedback, positive or negative
  Suggestions

 
25

 
 
APPENDIX E
 
ROYALTY REPORT FORMAT
 
Licensee: _______________ Agreement No.: _______
 
Period Covered:                    [ ]           January 1 -March 31
[ ]           April 1 -June 30
[ ]           July 1 -September 30
[ ]           October I -December31

Approved By: ______________    Date:                              
 
 
Note: If license covers several major product lines or sublicenses, please prepare a separate report for each product line or sublicense. Then combine all product lines or sublicenses into a summary report. Under a separate coversheet indicate any fee, annual license fee and royalties in excess of annual fees due the University. All reports must be submitted in U.S. Dollars.
 
 

• The use, manufacture or sale of LICENSED INVENTIONS or the provision of LICENSED SERVICES by the Licensee and, if permitted by License Agreement, the number of LICENSED INVENTIONS sold or LICENSED SERVICES provided by the Licensee's sublicensee(s).
•• As stipulated in Paragraph 4.4 of the License Agreement.
 
 
26

Exhibit 10.4

PROJECT PARTICIPATION AGREEMENT

This Project Participation Agreement (this "Agreement") is made and entered into as of September 21, 2006 by and between the Incorporated County of Los Alamos, an incorporated County of the State of New Mexico, (the "County"), and Caldera Pharmaceuticals Inc., a Delaware corporation qualified to do business in New Mexico, ("Caldera").

RECITALS

THE PARTIES HERETO enter into this Agreement on the basis of the following facts, understandings, and intentions:

A. The County has adopted Ordinance No. 501, An Ordinance Establishing an Economic Development Plan which ordinance was enacted pursuant to the express authority conferred upon municipalities by the Local Economic Development Act 5-10-1 to 5-l0-13, NMSA 1978) to allow the public support of economic development to foster, promote, and enhance local economic development efforts through the use of project participation agreements with qualifying entities while continuing to protect against the unauthorized use of public money and other public resources.

B. The County has adopted Ordinance No. 512 providing for the public support of Caldera (the "Project") in the form of a loan (the "Project Loan") in the principal amount not to exceed Two Million Two Hundred Thousand Dollars ($2,200,000) for construction of a building (the "Building") and purchase of equipment (the "Equipment“).

C. Caldera's economic activity complies with the local Economic Development Plan adopted by the County on May 3, 2005, by providing a public benefit to the residents of the County in the following respects:

(1) Caldera proposes to establish its financial and management stability by procurement of a matching investment from qualified sources and utilization of a Chief Executive Officer with experience in spin-off technology companies.

(2) The cost-benefit to the community of the Project and the activity of Caldera is demonstrated by a total investment of two times the County's public support in slightly over one year, and a total investment of five times the County's public support in slightly over two years, with a projected investment of eighteen times the County's public support in five years.

(3) Caldera‘s economic activity meets the objective of economic diversification by creating a biotech industry for which there is no competing biotech industry in the County, generating $10-25 million dollars of Research and Development Spending from out-of-state prospective customers or financial backers and by selling to pharmaceutical companies and other customers.

(4) Ca1dera's economic activity meets the objective of expansion of the tax base by generating increased taxes from the purchase of equipment within the County.

(5) Ca1dera‘s economic activity meets the objective of increased job and income opportunities by proposing to create 100 primary and 250 secondary jobs.

(6) Caldera's economic activity meets the objective of recruitment of businesses that utilize the County's science and technology assets and which complement and support the Los Alamos National Laboratory by expanding the scientific employment base.

(7) Caldera is a private business that provides a biotech laboratory space and contract research and development for the pharmaceutical industry. Caldera enhances the ability of County businesses to operate and expand by encouraging technology spin-offs, and is seeking to build, expand, or relocate facilities by building a commercial biotech laboratory.
 
 
1

 

 
(8) Caldera is a research and development and high technology firm engaged in pharmaceutical development that enhances the technology base of the County by retaining scientists who might otherwise not find employment within the County.

(9) Caldera enhances the exporting capacity of companies or reduces the net level of imports in the local economy by creating a customer base and use of financial backers from outside New Mexico.

(10) Caldera has obtained commitments for four million five hundred thousand dollars ($4,500,000), consisting of an equity investment agreement of two million five hundred thousand dollars ($2,500,000) and a research and development contract for two million dollars ($2,000,000).

D. The County and Caldera have entered into a Loan Agreement (the "Loan Agreement") and a Promissory Note (the "Promissory Note"), of even date herewith for the Project Loan.

E. As a condition precedent to its receipt of public assistance in the form bf the Project Loan, Caldera is required to execute this Project Participation Agreement.

AGREEMENT

NOW, THEREFORE, in consideration of the foregoing recitals and the covenants and promises herein, and for other good and valuable consideration, the receipt and sufficiency of which is hereby acknowledged, the parties agree as follows:

1. Contributions of the County:

(a) Investment. The County will contribute an amount not to exceed Two Million Two Hundred Thousand Dollars ($2,200,000) in the form of a loan (the "Project Loan"), the proceeds of which shall be used to secure and repay a construction loan for construction of the Building and purchase of the Equipment for use in Los Alamos County. Prior to commencing construction of the Building, Caldera shall submit to the County building designs and constructions specifications for the County's review and approval.

(b) Disbursement. Disbursement of the Project Loan shall be as follows:

(i) The County shall release to Caldera to reimburse Caldera for Equipment purchased by Caldera, upon receipt of the equipment by Caldera and upon Caldera providing serial numbers and product descriptions of all assets to the County.

(ii) The County shall release to Caldera the Project Loan on a schedule agreed to in the Construction Agreement (as defined in the Loan Agreement) and approved by the County.

(c) Contingencies. The disbursement of the Project Loan described in this section shall be contingent upon the following:

(i) Caldera shall obtain secured and non-revocable financing commitment(s) from sources other than the County in the amount of Four Million Four Hundred Thousand Dollars ($4,400,000) prior to the disbursal of any funds.

(ii) Caldera shall enter into legal and binding employment contracts with Benjamin Warner as President and Chief Executive Officer for a minimum of three years attached hereto as Exhibit A (provided, however, that the financial terms may be redacted). Caldera may replace Benjamin Warner as President and Chief Executive Officer, provided that Caldera provides a new President and Chief Executive Officer acceptable to the County within ninety (90) days after the replacement of Benjamin Warner.
 
 
2

 
 
2. Contributions of Caldera.

(a) First Additional Investment. No later than the end of one year from the effective date of this Agreement, Caldera shall have realized private investment and related economic activity of Four Million Four Hundred Thousand Dollars ($4,400,000).

(b) Second Additional Investment. No later than the end of three years from the effective date of this Agreement, Caldera shall have realized private investment and related economic activity of Eleven Million Dollars ($11,000,000).

(c) "Private Investment and Related Economic Activity”. As used above, "private investment and related economic activity" shall include all financing of Caldera, including equity investments, loans, gross receipts taxes paid by Caldera in the County; property taxes paid by Caldera in the County; and direct expenditures by Caldera including employee Wages and benefits for employees domiciled in the County or working in the County but not including building construction expenditures paid for directly or indirectly by the Project Loan.

(d) Employment. Caldera shall create the following number of Full Time Equivalent jobs (i.e., 2080 hours annually each, employed and salaries paid directly by Caldera) by the anniversary dates of the signing of this Agreement:

 
1 st
2dn
3 rd
4 th
5 th
6 th
7 th
Total FTE
1
15
27
40
54
75
100

(i) Promotion. Caldera shall make good faith efforts to promote Los Alamos County as a good and desirable place to live and Work.

3. Performance Review and Measurement. Caldera shall, within 90 days of the end of each year during the term of this Agreement, provide the County with a written report of its progress in achieving the performance measures required by Section 2 ("Contributions of Caldera") above (collectively, the "Performance Measures"). Thereafter, for each year during the term of this Agreement, Caldera may at the sole option of the County Administrator's Office be subject to an annual performance review and audit conducted by the County Administrator's Office or its designee to evaluate whether Caldera has achieved the Performance Measures. Caldera shall fully cooperate in the performance review and audit process by making all of its personnel, employees, and books and records available to the County at all reasonable times upon request. Caldera shall be permitted to submit credible proof of "private investment and related economic activity" to demonstrate that it has met the Performance Measures. All information regarding Caldera shall be treated in confidence to the fullest extent allowed by law; provided, however, that nothing in this Agreement shall be construed or permit or require the County to circumvent, obstruct, or fail to comply with the New Mexico Inspection of Public Records Act, 14-2-l et seq. (NMSA 1978).

4. Security. Caldera shall furnish the following security for the Project Loan:

(a) Building. The Building will be constructed within the County. Prior to construction, Caldera shall submit its plans to the County for the County's review and approval. Approval by the County pursuant to this subsection shall only constitute approval pursuant to this Agreement and shall neither imply nor constitute approval under applicable statutes, ordinances, and regulations, all of which shall remain the obligation of Caldera. The County, at its option, may require Caldera to enter into additional agreements to secure the County's interest in the Building.

(b) Equipment. Caldera shall grant a security interest, in a form and manner acceptable to the County, in all the Equipment paid for in whole or in part with the Project Loan. Such security interest shall be superior to any other security interests in the Equipment. Caldera shall not remove the Equipment from the County Without the County's written approval.

5. Termination and Recovery of Investment.

(a) Events of Default. The following events shall constitute events of default under this Agreement:
 
 
3

 
 
(i) Failure of Caldera to fulfill, in Whole or in part, any Performance Measure or other obligation required by this Agreement.

(ii) Cessation by Caldera of its management or its research and development operations in the County, or reduction of either of those operations in the County to a level below the Performance Measures.

(iii) Filing by Caldera of a petition, case, proceeding, or other action against the County as a debtor under any debtor relief law or seeking appointment of a receiver, trustee, custodian, or liquidator of Caldera, the Building, or any of the Equipment.

(iv) The abandonment by Caldera of all or a portion of the Building.

(v) The discovery by the County that any representation, warranty, or covenant made by Caldera in connection with this Agreement, the Loan Agreement, or the Promissory Note was or has become false, materially misleading, erroneous, or breached in any material respect.

(vi) Caldera assigns, sells, hypothecates, or transfers a majority interest in its business entity, whether in a single transaction or a series of transactions. (If Caldera desires to assign, sell, hypothecate, or transfer a majority interest in its business entity, whether in a single transaction or a series of transactions, before expiration of this Agreement, the County retains the right to reject any and all assignments, sales, hypothecations, or transfers of any interest in Caldera's business entity until, in the sole discretion of the County, adequate assurances are given that the assignee, buyer, hypothecatee, or transferee is a qualifying entity under the Los Alamos Economic Development Plan and that terms of this Agreement will be satisfied by the assignee, buyer, hypothecatee, or transferee.)

(vii) Caldera or any subsidiaries of Caldera conduct business operations with greater than a cumulative total of fifty employees based or located outside of the County.

(b) Caldera Response to Default. Upon the occurrence of an event of default by Caldera specified in this Agreement, the County shall notify Caldera in writing that an event of default has occurred under this Agreement. Within thirty (30) days of the receipt of such notice, Caldera shall:

(i) Cause the default to be cured; or

(ii) Furnish a written response indicating:

(1) The factors which caused or contributed, in whole or in part, to the occurrence of default;

(2) The measures Caldera has undertaken to avoid the reoccurrence of default in the future;

(3) Whether any Performance Measure not achieved can still be achieved in a timeframe acceptable to the County; and

(4) What further action Caldera plans to take to achieve the Performance Measure in a timeframe acceptable to the County.

(c) County Response to Default. The County staff shall review the response furnished  by Caldera and within thirty (30) days from the receipt of such response, recommend to the County Council Whether to modify or terminate this Participation Agreement. Caldera shall have an opportunity to make a presentation to the County Council at any meeting where such recommendation will be acted upon. The decision of the County Council will be final and binding. Other than the opportunity for Caldera to make a presentation to the County Council, in the event of default nothing herein shall be construed to limit in any way the power and authority of the County Council to take any of the following actions, all of which are hereby authorized by this Agreement:
 
 
4

 

 
(i) To terminate this Agreement and to demand immediate repayment of the Project Loan, including all interest both accrued and deferred; and to foreclose upon, collect, and recover all collateral pledged by Caldera as security for the Project Loan, the Building, or the Equipment if repayment is not made;

(ii) To terminate any interest deferral provisions in the Loan Agreement or the Promissory Note;

(iii) To increase the interest rate under the Promissory Note to prime plus two percent (2%);

(iv) To do any, some, or all of the foregoing.

6. Term. The term of this Agreement shall commence on the effective date of this Agreement and continue for thirteen (13) years unless terminated sooner as provided herein. If the Loan Agreement or the Promissory Note is extended for any reason, then the term of this Agreement shall automatically be extended so that the agreements are of the same duration. Caldera has the right to repay the Project Loan and any interest accrued or deferred at any time without any prepayment penalty.

7. Obligation to Perform. The failure of the County to insist, in any one or more instances, upon performance of any of the terms or covenants of this Agreement shall not be construed as a Waiver or relinquishment of the County's right to the future performance of any such terms and covenants, and the obligations of Caldera with respect to such future performance shall continue in full force and effect.

8. Excusable Delay. Caldera and the County shall be excused from performance for any period that they are prevented from performing any obligation hereunder in whole or in part as a result of an act of God, war, civil disturbance, epidemic, court order, or other cause beyond their reasonable control, and such nonperformance shall not be a ground for termination of this Agreement but shall not by itself extend the term of this Agreement.

9. Notices. All notices and communications required or permitted under this Agreement (including change of address and facsimile or telephone number set forth below) shall be in Writing and shall be deemed given to, and received by, the receiving party: (i) when hand-delivered to the street address of the receiving party set forth below; (ii) when sent by facsimile transmission to the facsimile number of the receiving party set forth below; (iii) one (l) day after deposit with a national overnight courier addressed to the receiving party at the street address set forth below; or (iv) five (5) days after deposit in the U. S. mail, certified mail, return receipt requested, postage prepaid, addressed to the receiving party at the mailing address set forth below.

The County:         County Administrator
Incorporated County of Los Alamos
Post Box 30
Los Alamos, New Mexico 87544
Telephone No.1 (505) 662-8080
Facsimile No.: (505) 662-8079

Caldera:                  Benjamin Warner, Ph.D., President
Caldera Pharmaceuticals, Inc.
3491 Trinity Drive, Suite B
Los Alamos, New Mexico 87544
Telephone No.1 (505) 661-2420
Facsimile No.1 (302) 347-1326

10. Amendment. This Agreement shall not be altered, changed, or amended other than by a written instrument executed by the parties.

ll. Assignment. Caldera shall not assign or transfer any rights, obligations, duties, or other interest in this Agreement, or assign any claim for money due under this Agreement, without the prior written consent of the County, which consent may be withheld in the County's sole and absolute discretion.
 
 
5

 
 
12. Appropriations. The performance by the County of any of the terms, covenants, or conditions in this Agreement that the County is obligated to perform shall be subject to the availability of appropriated funds that may be lawfully used for such purpose.

13. Partnership. Nothing contained in this Agreement shall be construed as creating or establishing a joint venture or partnership between the County and Caldera.

14. Indemnification. Caldera shall hold harmless, indemnify and defend the County, its officials, employees, agents, successors, and assigns from any and all liabilities, damages, claims, suits, or actions, of any kind or nature, arising out of Caldera's operations or this Agreement, including all costs, expenses, attorneys‘ fees (including attorneys’ fees incurred in connection with, and/or staff attorneys salaries allocable to, any action the County takes to enforce this Agreement) and any judgment or settlement thereof.

15. Authority. The individua1(s) signing this Agreement on behalf of Caldera represent and warrant that they have the power and authority to bind Caldera, and that no further action, resolution, or approval from Caldera is necessary to enter into a binding contract.

16. Incorporation. Each and all of the recitals set forth at the beginning of this instrument, and any exhibits referenced herein and attached hereto, are incorporated herein by this reference.

17. Calculation of Time. Any time period herein calculated by reference to "days" means calendar days, i. e., including Saturdays, Sundays, and holidays as observed by the State of New Mexico; provided, however, that if the last day for a given act falls on a Saturday, Sunday, or such observed holiday, the day for such act shall be first day following such Saturday, Sunday, or observed holiday that is not a Saturday, Sunday, or such observed holiday.

18. Interpretation. The captions and paragraph headings of this Agreement are not necessarily descriptive, or intended or represented to be descriptive, of all the terms thereunder, and shall not be deemed to limit, define, or enlarge the terms of this Agreement. Whenever used herein, unless otherwise indicated by the context, the singular shall include the plural, the plural shall include the singular, the use of any gender shall include all genders, and the use of the Words "include" and "including" shall be construed as if the phrases "without limitation" or "but not [be] limited to" were annexed thereafter. The parties Were, or had ample opportunity to be, represented by counsel, and as such this Agreement shall not be interpreted for or against either party based on authorship. The use herein of "Caldera" shall, where reasonable in the best interests of the County, be deemed to indicate and/or include all of the owners, partners, members, and employees of Caldera; provided, however, that such interpretation shall not be used in connection with Caldera's indemnity obligations contained in this Agreement.

19. Applicable Law. Each party shall perform its obligations hereunder in accordance with all applicable laws, rules, and regulations now or hereafter in effect. This Agreement shall be governed by the laws of the State of New Mexico (without giving effect to the State of New Mexic0’s choice of law provisions).

20. Survival. Terms of this Agreement that provide for rights, duties, and/or obligations that expressly or logically extend beyond the expiration or earlier termination of this Agreement, including Caldera's indemnity obligations, shall survive such expiration or earlier termination of this Agreement.

21. Severability. If any terms of this Agreement, or the application of such terms to any circumstance, person, or entity, shall be held illegal, invalid, or unenforceable, the remainder of this Agreement, or the application of such terms to persons or circumstances other than those to which it is held illegal, invalid, or unenforceable, shall not be affected; provided, however, that the remainder of this Agreement is still capable of performance in substantial accordance with the original intent of the parties.

22. Entire Agreement. This Agreement, the Loan Agreement, and the Promissory Note entered into by and between the parties and incorporated by reference as if fully set forth herein contain the entire understanding of the parties with respect to the subject matter hereof, and reflects all agreements and commitments made prior to the date hereof with respect to this Agreement by the County and Caldera. There are no other oral or written understandings, terms or conditions, and neither the County nor Caldera has relied upon any representation or statement, express or implied, that is not contained in this Agreement. Any modification of this Agreement and the understandings contained herein shall be in writing and executed by the County and Caldera.

[Signatures and approvals on following page.]

 
6

 


IN WITNESS WHEREOF, the parties have entered into this Project Participation Agreement effective as of the date first Written above (the "Effective Date").
 
INCORPORATED COUNTY OF LOS ALAMOS     Attest  
         
/Max Baker/   
   
/Mary Pat Kramer/
 
Marx H. Baker, County Administrator
   
Mary Pat Kraemer, County Clerk
 
 
   
 
 

Approved to Form
/Peter A. Dwyer/
Peter A. Dwyer, County Attorney
 
Caldera Pharmaceuticals, Inc.
a Delaware corporation

by:          /Benjamin Warner//
Benjamin Warner, Ph.D.
President


 
7

 


Exhibit A
to
Participation Agreement
CONTRACT OF BENJAMIN WARNER

[to be added]


 
8

 
 
LOAN AGREEMENT

This Loan Agreement (this "Loan Agreement") is made and entered into as of September 21, 2006 (the "Effective Date") by and between the Incorporated County of Los Alamos, an incorporated County of the State of New Mexico, (the "County"), and Caldera Pharmaceuticals Inc., a Delaware corporation qualified to do business in New Mexico, ("Borrower").

RECITALS

THE PARTIES HERETO enter into this Loan Agreement on the basis of the following facts, understandings, and intentions:

A. The County has adopted Ordinance No. 501, An Ordinance Establishing an Economic Development Plan which ordinance Was enacted pursuant to the express authority conferred upon municipalities by the Local Economic Development Act 5-10-l to 5-l0-13, NMSA 1978) to allow the public support of economic development to foster, promote, and enhance local economic development efforts through the use of project participation agreements with qualifying entities While continuing to protect against the unauthorized use of public money and other public resources.

B. The County has adopted Ordinance No. 512 providing for the public support of Borrower (the "Project") in the form of a loan (the "Project Loan") in the principal amount not to exceed Two Million Two Hundred Thousand Dollars ($2,200,000) for construction of a building (the "Building") and purchase of analytical and manufacturing equipment (the "Equipment").

C. Borrower's economic activity complies with the local Economic Development Plan adopted by the County on May 3, 2005, and will provide public benefit to the residents of the County.

D. The County and Borrower have entered into a Participation Agreement (the "Participation Agreement") and a Promissory Note (the "Promissory Note"), of even date herewith for the Project Loan (collectively, with this Agreement, the "Loan Documents"). As a condition precedent to its receipt of public assistance in the form of the Project Loan, Borrower is required to execute this Loan Agreement.

AGREEMENT

NOW, THEREFORE, in consideration of the foregoing recitals and the covenants and promises contained herein, and for other good and valuable consideration, the receipt and efficiency of which is hereby acknowledged, the parties agree as follows:

1. Loan Amount.

(a)  
The principal amount of the loan will not exceed Two Million Two Hundred K Thousand; Dollars ($2,200,000) (the "Loan Amount"). The anticipated amortization schedule (the "Amortization Schedule") is attached hereto as Attachment A.
(b)  
Pursuant to the terms of the Promissory Note and the Participation Agreement, the County shall disburse the loan proceeds as Borrower may request in amounts consistent with this Loan Agreement, the Participation Agreement, and Los Alamos County Ordinance No. 512. Such disbursements shall commence on or after the effective date of this Loan Agreement and the Participation Agreement and shall continue in no event later than the close of business on September 21, 2008 in an aggregate amount not to exceed the Loan Amount.

(c)  
If, at close of business on September 21, 2008, the County has not disbursed the entire Loan Amount, the County will prepare a new Amortization Schedule reflecting the amount of the loan proceeds actually disbursed and Borrower shall be required to repay the principal amount of the loan actually disbursed at the interest rate provided herein and in such amounts as the new Amortization Schedule shall provide. Any new Amortization Schedule prepared pursuant to the requirements of this provision shall become a part of this Loan Agreement replacing Attachment A hereto and shall be incorporated by reference as if fully set forth herein.
 
 
9

 
 
2. Project Description. The County will provide the following public support, in the form of a loan, as an economic development project approved by Ordinance No. 512 and pursuant to the County's Economic Development Plan (Ordinance No. 501). Borrower shall expend the loan proceeds to secure and repay a construction loan for construction of the Building and purchase of the Equipment for use therein in Los Alamos County. Buyer shall use no more than $625,000 of the loan proceeds for purchase of the Equipment. The loan proceeds shall be disbursed to reimburse Borrower for amounts expended.

3. Construction.

(a)  
Plans and Specifications. The Building shall be constructed in accordance with Plans and Specifications (the "Plans and Specifications") which Borrower will hereafter submit to the County for the County's approval prior to commencement of construction. The County will approve or disapprove the Plans and Specifications Within ninety (90) days of receipt of full and final Plans and Specifications. Approval by the County pursuant to this subsection shall only constitute approval pursuant to this Agreement and shall neither imply nor constitute approval under applicable statutes, ordinances, and regulations, all of which shall remain the obligation of Borrower.

(b)  
Construction Agreement. Borrower will enter into a construction agreement (the "Construction Agreement") pursuant to the terms and conditions of which the contractor (the "Contractor") is to construct the Building, which Construction Agreement shall first be submitted to the County for approval. The County will approve or disapprove the Construction Agreement Within ninety (90) days of receipt of full and final copy thereof. Borrower shall require Contractor to perform in accordance with the terms of the Construction Agreement and shall not amend, modify, or alter the responsibilities of Contractor under the Construction Agreement without the County's prior written consent. Borrower shall execute, upon the County‘s request, an assignment of Borrower‘s rights under the Construction Agreement to the County as security for Borrower's obligations under this Agreement and shall cause the Contractor to consent to any such assignment.

(c)  
Architect's Agreement. Borrower Will enter into an architect's agreement (the "Architect's Agreement"), pursuant to which the architect (the "Architect") is to design the Building, which Architect's Agreement shall first be submitted to the County for approval. Borrower shall require Architect to perform in accordance with the terms of the Architect's Agreement and shall not amend, modify, or alter the responsibilities of Architect under the Architect's Agreement without the County's prior written consent. Upon the County's request, Borrower shall execute an assignment of the Architect's Agreement and the Plans and Specifications to the County as additional security for Borrower's performance under this Agreement and shall cause the Architect to consent to any such assignment.

(d)  
Prohibited Contracts. Without the County's prior Written consent, Borrower shall not contract for any materials, furnishings, equipment, fixtures, or other parts or components of the Building, if any third party shall retain any ownership interest (other than lien rights created by operation of law) in such items after their delivery to the Building.

(e)  
Liens. If a claim of lien is recorded which affects the Building is served upon the County, Borrower shall, Within twenty (20) calendar days of such service or within five (5) calendar days of the County's demand, whichever occurs first: (i) pay and discharge the claim of lien; (ii) effect the release thereof by recording or delivering to the County a surety bond in sufficient form and amount; or (iii) provide the County with other assurances which the County deems, in its sole discretion, to be satisfactory for the payment of such claim of lien and for the full and continuous protection of the County from the effect of such lien.
 
 
10

 
 
(f)  
Construction Responsibilities. Borrower shall construct the Building in a workmanlike manner according to the Plans and Specifications and the recommendations of any soils or engineering report. Borrower shall comply with all applicable laws, ordinances, rules, regulations, building restrictions, recorded covenants and restrictions, and requirements of all regulatory authorities having jurisdiction over the Building. Borrower shall be solely responsible for all aspects of Borrower's business and conduct in connection with the Building, including, without limitation, for the quality and suitability of the Plans and Specifications and their compliance with all governmental requirements, the supervision of the work of construction, the qualifications, financial condition and performance of all architects, engineers, contractors, material suppliers, consultants and property managers, and the accuracy of all applications for payment and the proper application of all disbursements. The County is not obligated to supervise, inspect or inform Borrower or any third party of any aspect of the construction of the Building or any other matter referred to above.

(g)  
Inspections. The County shall have the right to enter upon the Building at all reasonable times to inspect the Building and the construction work to verify information disclosed or required pursuant to this Agreement. Any inspection or review of the Building by the County is solely to determine whether Borrower is properly discharging its obligations to the County and may not be relied upon by Borrower or by any third party as a representation or warranty of compliance with this Agreement or any other agreement. The County owes no duty of care to Borrower or any third party to protect against, or to inform Borrower or any third party of, any negligent, faulty, inadequate or defective design or construction of the Building as determined by the County.

4. Insurance. Borrower shall, while any obligation of Borrower under any Loan Document remains outstanding, maintain at Borrower's sole expense, with licensed insurers approved by the County, the following policies of insurance in form and substance satisfactory to the County:

(a)  
Property Insurance. A Builders Risk Completed Value Hazard Insurance policy, including, Without limitation, such endorsements as the County may require, insuring the County against damage to the Building in an amount acceptable to the County.

(b)  
Liability Insurance. A policy of comprehensive general liability insurance with limits as required by the County, insuring against liability for injury and/or death to any person and/or damage to any property occurring on the Building and/or in the Building from any cause whatsoever.

5. Disclosure Statement and Finance Costs.

(a)  
The annual percentage rate shall be five percent (5%). Interest shall accrue from and disbursement of any portion of the Loan Amount. Principal and interest payments Will be deferred for the thirty-six (3 6) months from the Effective Date of this Loan Agreement; provided, however, that all sums (principal and interest) shall be amortized over the remaining term of the loan.

(b)  
Finance charges shall total Six Hundred Thirty-Seven Thousand Six Hundred Thirty-Seven Dollars and Seventy Cents ($637,637.70).

(c)  
The amount financed shall total Two Million Three Hundred Thirty-Seven Thousand Five Hundred Dollars ($2,3 37,500.00).

(d)  
Total of payments shall be Two Million Nine Hundred Seventy-Five Thousand One Hundred Thirty-Seven Dollars and Twenty Cents ($2,975,137.20).

(e)  
All past due installments of principal and interest, including the unpaid balance of principal and interest during the existence of any default and after maturity of the Promissory Note, shall bear interest at the rate of the prime rate plus two percent (2%).

6. Repayment Schedule. The first payment of the principal and interest on this Loan Agreement shall become due as stated below:

(a)  
The number of payments shall be one hundred twenty (120).
 
 
11

 
 
(b)  
The amount of each payment shall be Twenty-Four Thousand Seven Hundred Ninety-Two Dollars and Eight-One Cents ($24,792.81).

(c)  
The first payment is due thirty-six (36) months from the Effective Date of this Loan Agreement, and on the first day of each month thereafter for ten (10) years, or sooner until the amounts payable hereunder are paid in full.

(d)  
The Promissory Note may be prepaid in Whole or in part at any time Without premium or penalty. No partial prepayment shall affect the obligation of Borrower to pay the regular installments due hereunder until the Promissory Note has been paid in full

7. Security. In addition to Borrower's pledge of financial or material participation and cooperation to ‘guarantee the Borrower's performance pursuant to the Participation Agreement executed of even date herewith, Borrower shall pledge as security for this Loan Agreement the following:

(a)  
Building. Borrower shall grant a security interest, in a form and manner acceptable to the County, in the Building. Such security interest shall be superior to any other security interests in the Building. The Building will be constructed in Los Alamos County as approved by the County.

(b)  
Equipment. Borrower shall grant a security interest, in a form and manner acceptable to the County, in all the Equipment paid for in Whole or in part with the Project Loan. Such security interest shall be superior to any other security interests in the Equipment. Borrower shall not remove the Equipment from the County without the County's Written approval.

8. Representations and Warranties. As a material inducement to the County's entry into this Agreement, Borrower represents and warrants to the County as of the date of this Agreement and continuing thereafter that:

(a)  
Authority. Borrower is in compliance with all laws and regulations applicable to its organization, existence and transaction of business and has all necessary rights and powers to own and develop the Building as contemplated by the Loan Documents.

(b)  
Binding Obligations. Borrower is authorized to execute, deliver and perform its obligations under the Loan Documents, and such obligations shall be valid and binding obligations of Borrower.

(c)  
Formation. Borrower has delivered to the County all formation and organizational documents of Borrower, of the partners, joint venturers or members of Borrower, if any, and all such formation and organizational documents remain in full force and effect and have not been amended or modified since they Were delivered to the County. Borrower shall immediately provide the County with copies of any amendments or modifications of the formation or organizational documents.
(d)  
No Violation. Borrower's execution, delivery, and performance under the Loan Documents do not: (i) require any consent or approval not heretofore obtained under any partnership agreement, operating agreement, articles of incorporation, bylaws or other document; (ii) violate any governmental requirement applicable to the Building or any other statute, law, regulation or ordinance or any order or ruling of any court or governmental entity; (iii) conflict with, or constitute a breach or default or permit the acceleration of obligations under any agreement, contract, lease, or other document by which the Borrower is or the Building are bound or regulated; or (iv) violate any statute, law, regulation or ordinance, or any order of any court or governmental entity.

(e)  
Compliance with Laws. Borrower has, and at all times shall have obtained, all permits, licenses, exemptions, and approvals necessary to construct, occupy, operate and market the Building, and shall maintain compliance with all governmental requirements applicable to the Building and all other applicable statues, laws, regulations and ordinances necessary for the transaction of its business.

(f)  
Litigation. Except as disclosed to the County in Writing, there are no claims, actions, suits, or proceedings pending, or to Borrower's knowledge threatened, against Borrower or affecting the Building.
 
 
12

 
 
(g)  
Financial Condition. All financial statements and information heretofore delivered to the County by Borrower, including, without limitation, information relating to the financial condition of Borrower, the Building, the partners, joint venturers, shareholders or members of Borrower, fairly and accurately represent the financial condition of the subject thereof and have been prepared (except as noted therein) in accordance with generally accepted accounting principles consistently applied. Borrower acknowledges and agrees that the County may request and obtain additional information from third parties regarding any of the above, including, without limitation, credit reports.

(h)  
Material Adverse Change. There has been no material adverse change in the financial condition of Borrower since the dates of the latest financial statements furnished to the County and, except as otherwise disclosed to the County in writing, Borrower has not entered into any material transaction which is not disclosed in such financial statements.
(a)  
Loan Agreement 092106.doc

(i)  
Accuracy. All reports, documents, instruments, information and forms of evidence delivered to the County concerning the Project Loan or security for the Project Loan or required by the Loan Documents are accurate, correct and sufficiently complete to give the County true and accurate knowledge of their subject matter, and do not contain any misrepresentation or omission.

(j)  
Taxes. Borrower has filed all required federal, state, and municipal tax returns and has paid all taxes and assessments owed and payable, and Borrower has no knowledge of any basis for any additional payment with respect to any such taxes and assessments.

(k)  
Utilities. All utility services, including, without limitation, gas, water, sewage, electrical, and telephone, necessary for the development and occupancy of the Building are available at or within the boundaries of the Building, or Borrower has taken all steps necessary to assure that all such services will be available upon completion of the Building.

(l)  
Compliance. Borrower is familiar with and in compliance with all governmental requirements for the construction of the Building and will conform to and comply with all governmental requirements and the Plans and Specifications.

(m)  
Americans with Disabilities Act. The Building shall been designed and shall be constructed and completed, and thereafter maintained, in strict accordance and full compliance With all of the requirements of the Americans With Disabilities Act, 42 U.S.C. § 12101, et. seq., as amended from time to time. Borrower shall be responsible for all ADA compliance costs.

9. Defaults. The occurrence of any one or more of the following shall constitute an event of default (hereinafter, "Default") under this Agreement and the other Loan Documents:

(a)  
Monetary. Borrower's failure to pay when due any sums payable under the Promissory Note or any of the other Loan Documents;

(b)  
Performance of Obligations. Borrower's failure to perform any obligation under any of the Loan Documents; provided, however, that if a cure period is provided for the remedy of such failure, Borrower's failure to perform will not constitute a Default until such date as the specified cure period expires;

(c)  
Representations and Warranties. (i) The failure of any representation or warranty of Borrower in any of the Loan Documents and the continuation of such failure for more than ten (10) days after written notice to Borrower from the County requesting that Borrower cure s/uchi failure; or (ii) any material adverse change in the financial condition of Borrower from the financial condition represented to the County as of the date of this Agreement;

(d)  
Voluntary Bankruptcy, Insolvency, Dissolution. (i) The filing of a petition by Borrower for relief under the Bankruptcy Code, or under any other present or future state or federal law regarding bankruptcy, reorganization or other debtor relief law; (ii) the filing of any pleading or an answer by Borrower in any involuntary proceeding under the Bankruptcy Code or other debtor relief law which admits the jurisdiction of the court or the petition's material allegations regarding Borrower's insolvency; (iii) a general assignment by Borrower for the benefit of creditors; or (iv) Borrower applying for, or the appointment of, a receiver, trustee, custodian or liquidator of Borrower or any of its property;
 
 
13

 
 
(e)  
Involuntary Bankruptcy. The failure of Borrower to effect a full dismissal of any involuntary petition under the Bankruptcy Code or under any other debtor relief law that is filed against Borrower or in any way restrains or limits Borrower or the County regarding the Project Loan or the Building, prior to the earlier of the entry of any court order granting relief sought in such involuntary petition, or thirty (30) days after the date of filing of such involuntary petition;

(f)  
Loss of Priority. The failure at any time of any security interest under any Loan Document to be a valid first lien upon the Building, the Equipment, or any portion thereof, other than as a result of any release by the County with respect to all or any portion of the Building or the Equipment pursuant to the terms and conditions of this Agreement;

(g)  
Default Under Leases. The occurrence of a default under a ground lease, lease, sublease, or other real property agreement affecting the Building;

(h)  
Key Person. The retirement, death, incapacity, termination, or Withdrawal of Benjamin Warner as Borrower's Chief Executive Officer and Borrower's failure to provide a substitute or replacement acceptable to the County within ninety (90) days after the occurrence of any such retirement, death, incapacity or Withdrawal;

(i)  
Transfer of Assets. The sale, assignment, pledge, hypothecation, mortgage or transfer of assets of Borrower other than in the ordinary course of business of said entity.

10. Remedies.

(a)  
Acceleration. Upon the occurrence of any Default which is not cured pursuant to the procedure described in the Participation Agreement, the County may, at its sole option, declare all sums owing to the County under the Promissory Note, this Agreement, and the other Loan Documents immediately due and payable, and any and all obligations of the County to fund further disbursements under the Loan shall terminate.

(b)  
Completion of Construction. Upon the occurrence of a Default which is not cured pursuant to the procedure described in the Participation Agreement, the County may, upon five (5) days prior written notice to Borrower, and with or without legal process, take possession of the Building, remove Borrower and all agents, employees and contractors of Borrower from the Building, complete the work of construction and market and sell or lease the Building. For this purpose, Borrower irrevocably appoints the County as its attorney-in-fact, which agency is coupled with an interest. As attorney-in-fact, the County may, in Borrower's name, take or omit to take any action the County may deem appropriate, including, without limitation, exercising Borrower's rights under the Loan Documents and all contracts concerning the Building.

(c)  
Cessation of Construction. If the County determines at any time that the Building is not being constructed in accordance with the Plans and Specifications and all governmental requirements, the County may immediately cause all construction to cease on any portion of the Building affected by the condition of nonconformance or the Building as a whole. Borrower shall thereafter not allow any construction Work, other than corrective work, to be performed on any portion of the Building affected by the condition of nonconformance until such time as the County notifies Borrower in writing that the nonconforming condition has been corrected.

(d)  
Repayment. Any funds expended by the County in the exercise of its rights or remedies under this Agreement and the other Loan Documents shall be payable to the County upon demand, together with interest at the rate applicable to the principal balance of the Promissory Note from the date the funds were expended.
 
 
14

 
 
(e)  
Cumulative Rights. All the County's rights and remedies provided in this Agreement and the other Loan Documents, together with those granted by law or at equity, are cumulative and may be exercised by the County at any time. The County's exercise of any right or remedy shall not constitute a cure of any Default unless all sums then due and payable to the County under the Loan Documents are repaid and Borrower has cured all other Defaults. No Waiver shall be implied from any failure of the County to take, or any delay by the County in taking, action concerning any Default or failure of condition under the Loan Documents, or from any previous waiver of any similar or unrelated Default or failure of condition. Any waiver or approval under any of the Loan Documents must be in writing and shall be limited to its specific terms.

11. Miscellaneous Provisions.

(a)  
Incorporation. This Loan Agreement is made pursuant to and in accordance with the provisions of Ordinance No. 501, Ordinance No. 512, the Local Economic Development Act, the Participation Agreement, and Promissory Note, all of which are incorporated by reference as if fully set forth herein.

(b)  
Further Assurances. Upon the County's request and at Borrower's sole cost and expense, Borrower shall execute, acknowledge and deliver any other instruments and perform any other acts necessary, desirable or proper, as determined by the County, to carry out the purposes of this Agreement and the other Loan Documents or to perfect and preserve any security interests created by or contemplated by the Loan Documents.

(c)  
Disbursements. Borrower covenants that all disbursements will be made in accordance with this Loan Agreement, the Promissory Note, the Participation Agreement, Ordinance No. 501, and Ordinance No. 512.

(d)  
Transfer of Assets. Borrower shall not sell or transfer any of the property, personal or real, financed in whole or in part by the proceeds of this Loan Agreement Without the express written consent of the County, which consent may be given in the County's sole discretion. The County may place conditions on its consent. Upon partial repayment of the Loan Amount, Caldera may request that the County release its security interest as to specific assets, which request the County may approve or deny in its sole discretion and which approval, if any, must be in writing.

(e)  
Information. Borrower will provide to the County serial numbers and product descriptions of all assets to be used as collateral or replacement collateral.

(f)  
Further Encumbrances. Borrower agrees that it will not obligate any of the collateral pledged as security for this Loan Agreement without the express written consent of the County, which consent may be given at the County's sole discretion.

(g)  
Notices. All notices and communications required or permitted under this Agreement (including change of address and facsimile or telephone number set forth below) shall be in writing and shall be deemed given to, and received by, the receiving party: (i) when hand-delivered to the street address of the receiving party set forth below; (ii) when sent by facsimile transmission to the facsimile number of the receiving party set forth below; (iii) one (1) day after deposit with a national overnight courier addressed to the receiving party at the street address set forth below; or (iv) five (5) days after deposit in the U. S. mail, certified mail, return receipt requested, postage prepaid, addressed to the receiving party at the mailing address set forth below.

The County:         County Administrator
Incorporated County of Los Alamos
Post Box 30
Los Alamos, New Mexico 87544
Telephone No.2 (505) 662-8080
Facsimile No.1 (505) 662-8079
 
 
15

 
 
Caldera:                  Benjamin Warner, Ph.D., President
Caldera Pharmaceuticals, Inc.
3491 Trinity Drive, Suite B
Los Alamos, New Mexico 87544
Telephone N0.: (505) 661-2420
Facsimile N0.: (302) 347-1326

(h)  
Indemnity. Borrower hereby agrees to defend, indemnify and hold harmless the County, its directors, officers, employees, agents, successors and assigns from and against any and all losses, damages, liabilities, claims, actions, judgments, court and legal or other expenses (including, without limitation, attorneys‘ fees and expenses) which the County may incur as a direct or indirect consequence of: (i) the purpose to which Borrower applies the Loan proceeds; (ii) the failure of Borrower to perform any obligations as and when required by this Agreement or any of the other Loan Documents; (iii) any failure at any time of any of Borrower's representations or warranties to be true and correct; or (iv) any act or omission by Borrower, constituent partner or member of Borrower, any contractor, subcontractor or material supplier, engineer, architect or other person or entity with respect to any of the Building. Borrower shall immediately pay to the County upon demand any amounts owing under this indemnity, together with interest from the date the indebtedness arises until paid at the rate of interest applicable to the principal balance of the Promissory Note. Borrower's duty and obligations to defend, indemnify and hold harmless the County shall survive cancellation of the Promissory Note and this Agreement.

(i)  
Joint and Several Liability. The liability of all persons and entities obligated in any manner under this Agreement and any of the Loan Documents shall be joint and several.

(j)  
Third Parties. No person other than the County and Borrower and their permitted successors and assigns shall have any right of action under any of the Loan Documents.

(k)  
Fees and Enforcement. If any attorney is engaged by the County to enforce or defend any provision of this Agreement, any of the other Loan Documents, or as a consequence of any Default under the Loan Documents, and if the County files an action in a court of competent jurisdiction, Borrower shall immediately pay to the County, upon demand, the amount of all attorneys’ fees and expenses and all costs incurred by the County in connection therewith, together with interest thereon from the date of such demand until paid at the rate of interest applicable to the principal balance of the Promissory Note as specified therein.

(l)  
Signs. The County may place on the Building reasonable signs standard to construction loan transactions stating that construction financing is being provided by the County and any other the County's or participants in the Project Loan.

(m)  
Agents. The County may designate an agent or independent contractor to exercise any of the County's rights under this Agreement and any of the other Loan Documents. Any reference to the County in any of the Loan Documents shall include the County's agents, employees, or independent contractors.

(n)  
Severability. If any provision or obligation under this Agreement and the other Loan Documents shall be determined by a court of competent jurisdiction to be invalid, illegal or unenforceable, that provision shall be deemed severed from the Loan Documents and the validity, legality and enforceability of the remaining provisions or obligations shall remain in full force as though the invalid, illegal, or unenforceable provision had never been a part of the Loan Documents, provided, however, that if the rate of interest any Loan Document is declared to be or become invalid, illegal, or unenforceable, the County's obligations to make advances under the Loan Documents shall not be enforceable by Borrower.

(o)  
Successors and Assigns. Except as otherwise expressly provided under the terms and conditions of this Agreement, the terms of the Loan Documents shall bind and inure to the benefit of the heirs, successors, and assigns of the parties.
 
 
16

 

 
(p)  
Time. Time is of the essence of each and every term of this Agreement.

(q)  
Governing Law. This Agreement shall be governed by, and construed and enforced in accordance with the laws of the State of New Mexico, except to the extent preempted by Federal laws. The County retains the right to seek enforcement of the terms of this Loan Agreement as provided herein and as provided by law. The parties agree that if the parties cannot reach agreement regarding disputes as to the terms and conditions of this Loan Agreement, such disputes are to be resolved as promptly and expeditiously as practicable in the First Judicial District Court of Los Alamos County which shall have exclusive jurisdiction, including venue, over the parties and the subject matter of this Loan Agreement and Waive the right to challenge such jurisdiction and venue.

(r)  
Integration. The Loan Documents, Ordinance No. 501, and Ordinance No. 512 contain or expressly incorporate by reference the entire agreement of the parties with respect to the matters contemplated therein and supersede all prior negotiations or agreements, written or oral. The Loan Documents shall not be modified except by Written instrument executed by all parties. Any reference in any of the Loan Documents to the Building shall include all or any part of the Building. Any reference to the Loan Documents includes any amendments, renewals or extensions now or hereafter approved by the County in Writing.

[Signatures and approvals on following page.]


 
17

 

 
IN WITNESS WHEREOF, the parties have entered into this Project Participation Agreement effective as of the "Effective Date".

 
INCORPORATED COUNTY OF LOS ALAMOS     Attest  
         
/Max Baker/   
   
/Mary Pat Kramer/
 
Marx H. Baker, County Administrator
   
Mary Pat Kraemer, County Clerk
 
 
   
 
 
 
Approved to Form
/Peter A. Dwyer/
Peter A. Dwyer, County Attorney


Caldera Pharmaceuticals, Inc.
a Delaware corporation

by:          /Benjamin Warner//
Benjamin Warner, Ph.D.
President

18

Exhibit 10.5
AMENDMENT NO. 1
INCORPORATED COUNTY OF LOS ALAMOS
PROJECT PARTICIPATION AGREEMENT

This AMENDMENT NO. 1 is entered into by and between the Incorporated County of Los Alamos, an incorporated county of the State of New Mexico ("County"), and Caldera Pharmaceuticals, Inc., a Delaware corporation ("Caldera"), to be effective for all purposes February 21, 2007.

WHEREAS, the parties desire to amend the Participation Agreement to reflect the equity investments and contract awards obtained by Caldera in meeting County’s Economic Development Plan and the benefits to the residents of the County;

WHEREAS, the parties desire to amend the Participation Agreement to require a two to one match in private investment from Caldera to initiate the release of County funds; and

WHEREAS, the parties desire to amend the Participation Agreement to permit Caldera to secure its Second Additional investment within five (5) years.

NOW, THEREFORE, good and valuable consideration, the parties agree as follows:

1. To delete Section C(10) of the Recitals in its entirety and replace it with the following:

(10) Caldera has obtained equity investment from private investors in the amount of One Million Four Hundred Seventy-Seven Thousand Dollars ($1,477,000) and has been awarded Department of Defense contracts in the amount of One Million Three Hundred Thirty-Tree Thousand Seventy-Eight Dollars ($1,333,078).

2. To delete Section 1(c) in its entirety and replace it with the following:

(c) Contingencies. The disbursement of the Project Loan described in this section shall be contingent upon the following:

(i) Caldera shall obtain secured and non-revocable financing commitment(s) from sources other than County in the amount of two times the actual amount of the funds to be disbursed of any funds; the disbursed funds shall not exceed Two Million Two Hundred Dollars ($2,200,000).

(ii) Caldera shall enter into legal and binding employment contracts with Benjamin Warner as President and Chief Executive Officer for a minimum of three years attached (provided, however, that the financial terms may be redacted"). Caldera may replace Benjamin Warner as President and Chief Executive, provided that Caldera provides a new President and Chief Executive Officer acceptable to the County within ninety (90) days after the replacement of Benjamin Warner.

3. To delete Section 2(a) in its entirety and replace it with the following::

(a) First Additional Investment. No later than the end of one year from the effective date of this Agreement, Caldera shall have realized private investment and related economic activity of Two Million Eight Hundred Ten Thousand Seventy-Eight Dollars ($2,810,078).

4. To delete Section 2(b) in its entirety and replace it with the following:

(b) Second Additional Investment. No later than the end of five (5) years from the effective date of -this Agreement, Caldera shall have realized private investment and related economic activity of Eleven Million Dollars ($11,000,000).

Except as expressly modified by this Amendment No. 1 the terms and conditions of the Agreement remain unchanged and in effect.
 
 
 

 
 
IN WITNESS WHEREOF, the parties have executed this Amendment No. 1 on the date(s) set forth opposite the signatures of their authorized representatives to be effective for all purposes on the date first written -above.

Attest:
/Mary Pat Kramer/
Mary Pat Kramer
County Clerk
 
Incorporated County of Los Alamos
/Max Baker/ 2/20/07
Max H. Baker
County Administrator

Approved to Form:
/Peter Dwyer/
Peter A. Dwyer
County Attorney

CALDERA PHARMACEUTICALS, INC., a Delaware corporation
/Benjamin Warner// 2/21/07
Benjamin Warner
President
 

 
Exhibit 10.6
 
CERTAIN PORTIONS OF THIS EXHIBIT HAVE BEEN OMITTED BASED UPON A REQUEST FOR CONFIDENTIAL TREATMENT WITH THE UNITED STATES SECURITIES AND EXCHANGE COMMISSION.  THE NON-PUBLIC INFORMATION HAS BEEN FILED WITH THE COMMISSION.





OEM AGREEMENT
 


between

 
Bruker Nano GmbH

having its Registered Office at
Schwarzschildstr. 10-12, 12489 Berlin, Germany,
 
together with its subsidiary and affiliate companies from time to time hereinafter referred to as " Bruker ",


and
 

Caldera Pharmaceuticals, Inc.

having its Registered Office at
1209 Orange Street, Wilmington, County of New Castle, Delaware, 19801, USA,
together with its subsidiary and affiliate companies from time to time hereinafter referred to as " Caldera ",

 

 
- Bruker and Caldera hereinafter referred to individually as "a Party"
 
and collectively as "the Parties" -

 
1

 

Table of Contents
 
Preamble  3
1.        Definitions  3
2.        Development of M4 BIO  3
3.        Promotion and Sale of XRPro  4
4.        M4 BIO Lead Time, Delivery, Forecasting  4
5.        M4 BIO Prices and Payment Terms  5
6.        M4 BIO Warranty  6
7.        XRPro Installation  6
8.        XRPro Technical Service and System Maintenance  6
9.        Non-Competition  6
10.            Confidentiality  7
11.            Limitation of Liability  7
12.            Duration of Agreement, Termination  8
13.            Assignment  9
14.            Notices  9
15.            Arbitration  10
16.            Applicable Law  10
17.            Protection of Goodwill of Products; Compliance with Law  10
18.            Written Form  10
19.            Legally Void or Unfeasible Provisions  10
 
 
2

 
 
Preamble

I.  
Bruker is engaged in the development, manufacture and sales of complete systems and components for micro- and nanoanalysis on electron microscopes (EDS, EBSD) as well as X-ray fluorescence spectrometry (small spot- and µXRF, TXRF). In particular Bruker is offering the M4 TORNADO, a high performance desk top µXRF analyzer with large sample chamber, high-speed XYZ-stage and spot size of < 100 µm.

II.  
Caldera pioneers in high-throughput label-free measurement of protein-drug binding and has developed a unique technology that is based on direct chemical analysis of protein-drug combinations by means of micro X-ray fluorescence (µXRF) spectroscopy. To date Caldera is offering its customers analytical services using its technology. An essential part of the technology is a desk top µXRF analyzer that Caldera used to source from third party vendors.

III.  
Recently, Caldera is faced with an increasing demand for a product from its customers, who are interested in establishing this technology in their own labs, rather than just buying the analyical service from Caldera. Caldera is therefore seeking to create a commercial product as a combination of a µXRF analyzer and Caldera’s technology.

IV.  
This OEM Agreement is intended to stipulate the terms and conditions under which
a.  
Bruker shall develop a customized version of the M4 TORNADO that meets the application specific requirements of Caldera’s technology,
b.  
Bruker shall manufacture and sell to Caldera the customized version of the M4 TORNADO,
c.  
Caldera shall promote, sell and support the product based on the customized version of the M4 TORNADO,
d.  
Bruker shall provide technical repair and maintenance service to Caldera’s customers.

 
1.  
Definitions
 
 
In this Agreement and its Annexes, the following definitions shall apply:
 
1.1  
The term “ M4 BIO ” means the customized version of the M4 TORNADO that meets the application specific requirements of Caldera’s technology, consisting of hardware and software as specified in Annex 1 to this Agreement.

1.2  
The term “ XRPro ” means the commercial product to be created by the Parties, incorporating the M4 Bio from Bruker and Caldera’s technology.


2.  
Development of M4 BIO

2.1.  
The Parties are in agreement that to the best of their knowledge the hardware and software specifications given in Annex 1 to this Agreement represent the complete and correct description of the M4 BIO.

2.2.  
Bruker undertakes to develop and implement the modifications and/or additional features to the standard software of the M4 TORNADO, necessary to meet the M4 BIO specifications as set out in Annex 1, within 3 months after the signing of this Agreement.

2.3.  
Bruker’s costs related to the development of the M4 BIO shall be borne by Bruker.

2.4.  
Upon completion of the development Bruker shall provide Caldera with a prototype M4 BIO on a loan basis. The terms and conditions of the loan will be agreed between the Parties in a separate loan agreement.
 
 
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2.5.  
If after delivery and test by Caldera of the prototype M4 BIO, Caldera should come to the conclusion that the software provided by Bruker is not fully meeting Caldera’s actual requirements, because
a)  
in Caldera’s understanding the functionality as described in Annex 1 has not been realized by Bruker to its full extent, or
b)  
the description of the required M4 BIO functionality as set out in Annex 1 was not entirely complete and correct, the Parties will jointly define and specify the remaining or additional development to be done by Bruker as well as a time schedule for the completion of such remaining or additional development.

2.6.  
If future technical progress and/or further development result in variations to the specification of the M4 BIO, or if such variations become necessary for other reasons, then Bruker shall notify Caldera in writing of such variations. The Parties shall then agree on an alteration or an amendment of this Agreement with respect to the specification, the pricing and the time schedule for the variation to become effective.

2.7.  
In the event that future alterations of the M4 BIO with respect to design or specification are desired by Caldera, then Caldera shall request such alterations in writing and provide Bruker with full particulars of such alterations. Provided that such requested alteration is technically feasible and economically reasonable, the Parties shall then agree on an alteration or an amendment of this Agreement with respect to the specification, the pricing and the time schedule for the alteration to become effective.

 
3.  
Promotion and Sale of XRPro

3.1.  
Caldera will be responsible for worldwide marketing and sales of the XRPro.

3.2.  
Subject to revocation by Bruker at any time, the XRPro shall be co-labeled with both Bruker’s and Caldera’s corporate logos, and Caldera shall be permitted to use the trademark Bruker and trademarks registered in Bruker's name for advertising and promotional purposes, provided that Caldera observes the applicable Bruker directives and uses only those trademark designs approved in writing in advance by Bruker. However Caldera shall not file for registration trade marks of Bruker in its own name. Upon request by Bruker or if required by law, Bruker and Caldera shall conclude a separate trademark license agreement.

3.3.  
Caldera shall not assume obligations in the name of or on the account of Bruker and shall not make any represent­ations or warranties on behalf of Bruker, except as expressly authorized by Bruker in writing.

3.4.  
Caldera shall be deemed at all times to be an independent contractor and nothing contained herein shall be deemed to create the relationship of employer and employee or joint venture between Caldera and Bruker.

3.5.  
Caldera shall strictly comply with all laws and regulations regarding the performance of its activities under this Agreement.


4.  
M4 BIO Lead Time, Delivery, Forecasting

4.1.  
The delivery of M4 BIO by Bruker to Caldera is subject to the conditions specified in "General Terms and Conditions of Bruker Nano GmbH“, attached as Annex 3 to this Agreement, unless otherwise provided for in this Agreement or in special conditions, as agreed upon, applicable to certain products, systems or services, types of business or special transactions.
 
 
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4.2.  
Bruker shall deliver M4 BIO upon the receipt of written purchase orders from Caldera. On the order sheet Caldera will indicate the complete customer details (address, telephone, fax, e-mail) as prerequisite for customer service by Bruker.

4.3.  
Standard lead time for the Product is XXXX from receipt and acceptance of order.

4.4.  
Bruker will shorten the lead time to XXXX if Caldera provides a 6 months rolling forecast on a monthly basis. Caldera will work closely with Bruker to manage a forecast and supply process to enable both Parties to profitably engage with all customer opportunities and required deliveries. Bruker will ensure capacity and production slots to meet this forecast. Each month Bruker and Caldera will review the planned capacity and capability to react to additional orders for the subsequent 6 calendar months.

4.5.  
Delivery shall be DAP to the delivery address specified on the purchase order.


5.  
M4 BIO Prices and Payment Terms

5.1.  
The configurations and prices for the M4 BIO, related options and services are given in Annex 1 to this Agreement. All prices are XXXX exclusively for the purpose of this Agreement. XXXX.

5.2.  
XXXX will be applied to the transfer prices as the total XXXX as per the table below.

Quantity sold
1-10
11-20
>20
XXXX
XXXX
XXXX
XXXX

The first XXXX will be invoiced at XXXX. If the XXXX is sold within the same period, XXXX. The total XXXX will be settled with the XXXX. If the XXXX is sold within the same period, the XXXX. The XXXX will be settled with the invoice for the XXXX.

The first 12 months period shall commence on the first day of the month in which Caldera receives the first purchase order for an XRPro from a customer.

5.3.  
The XXXX will be reviewed annually.

5.4.  
Bruker shall invoice Caldera
a)  
XXXX upon receipt of the purchase order;
b)  
XXXX upon delivery;
c)  
XXXX upon installation and acceptance at the customer.
Caldera shall pay invoices within XXXX from the invoice date. Payments shall be made in USD. In the event that Caldera is in arrears in payment of an invoice, XXXX.

5.5.  
Bruker shall retain title to the goods until payment in full for all deliveries. Caldera may resell the goods in the ordinary course of business and thereby assigns to Bruker as security all debts or claims arising from such resale.

XXXX - redacted pursuant to a confidentiality request with the United States Securities and Exchange Commission

 
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6.  
M4 BIO Warranty

6.1.  
Bruker warrants the M4 BIO to be free of defects in workmanship and materials when used under normal operating conditions and when applied in accordance with specifications. The warranty period for M4 BIO is 12 months from the date of installation of the XRPro at customer’s site, maximum 15 months from the date of shipment of the M4 Bio from Bruker to Caldera or the customer (Warranty Period).

6.2.  
During the Warranty Period all costs related to the making good of any defect shall be borne by Bruker, including any costs of the transport of defective items to be returned to Bruker and their return to Caldera or to the customer. This provision does not apply to products which exhibit a failure as a result of any act of negligence or omission by Caldera, its agents, representatives, its customers or any other third party.


7.  
XRPro Installation

7.1.  
Installation of XRPro systems and user training shall be provided by local Caldera or Caldera Local Rep service engineers, provided such engineers have been trained by Bruker and have obtained a certificate for M4 BIO installation and operation.

7.2.  
In case no certified Caldera or Caldera Local Rep engineer is available locally, installation and user training shall be done by a local Bruker engineer. Additional charges apply for the installation and training of the end user by Bruker personnel according to the M4 BIO Service Price List given in Annex 2 to this Agreement.


8.  
XRPro Technical Service and System Maintenance

8.1.  
Caldera shall provide the first line service contact to its XRPro customers.

8.2.  
If the initial diagnosis by Caldera suggests that a failure is related to the M4 BIO, Caldera shall notify the local Bruker Service in writing as soon as it is reasonably able. Bruker shall provide Caldera with contact details of local Bruker Service for each country or territory in which the XRPro has been installed.

8.3.  
Based on the customer’s / Caldera’s failure report, and supported by further investigations via telephone or on-site if necessary, Bruker Service shall provide a quote for the repair to the customer / Caldera. Upon receipt of the purchase order from the customer / Caldera Bruker Service shall repair the defective M4 BIO. Prices and rates for repair services are provided in Annex 2 to this Agreement.

8.4.  
Bruker offers Caldera / Caldera’s customers service contracts for the M4 BIO at different price / performance levels as set out in Annex 2 to this Agreement. Services provided by Bruker under service contracts and prices of service contracts may be country specific.


9.  
Non-Competition

9.1.  
Caldera shall not, without the prior written consent of Bruker
a)  
copy the M4 BIO or parts thereof;
b)  
develop, manufacture, act as intermediary for, or distribute products that compete directly or indirectly with the M4 BIO or parts thereof.

9.2.  
Bruker shall not, without the prior written consent of Caldera
a)  
make the M4 BIO available to any third party that competes directly or indirectly with Caldera;
b)  
make any attempts to market and sell the XRPro directly to end users.
 
 
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9.3.  
If this Agreement is terminated by either Party, the provisions of this Section 9 shall remain in force for a period of three years subsequent to the termination of this Agreement; except that if Bruker terminates the agreement, Subsection 9.1 shall be voided, and if Caldera terminates the agreement, Subsection 9.2 shall be voided.
 
9.4.  
If future technical progress or further business development requires the necessity to change the specifications of the M4 BIO, replace the M4 BIO with a next generation machine, or expand the XRpro product line with x-ray fluorescence equipment with greater or lesser capabilities than are provided by the M4 BIO, then Bruker shall have the right of first refusal to manufacture the x-ray fluorescence equipment. Bruker shall notify Caldera within 30 days of its election to manufacture the x-ray fluorescence equipment. Should Bruker elect not to manufacture the x-ray fluorescence equipment, then Caldera can make or have made the equipment without violating the provisions of Section 9.


10.  
Confidentiality

10.1.  
Either Party hereby undertakes to:
 
a)
keep confidential all information (written or oral) concerning the business and affairs of the other Party that it shall have obtained or received as a result of discussions leading up to or the entering into or in the performance of this Agreement. (the “Information”);
 
b)
not without the other Party's written consent disclose the information in whole or in part to any other person save those of its employees involved in the performance of this Agreement to whom such disclosure is necessary; and
 
c)
use the Information solely in connection with the performance of this Agreement and not for its own or the benefit of any other third party.

10.2.  
The provisions of subsection 10.1. shall not apply to the whole or any part of the Information to the extent that is:
 
a)
trivial or obvious;
 
b)
in the public domain;

10.3.  
The terms of this Section 10 shall survive the termination of this Agreement.


11.  
Limitation of Liability

11.1.  
Bruker shall not be responsible for the XRPro sold by Caldera or for claims of third parties with respect to the XRPro, if such claims are on account of failure on the part of Caldera to comply with all the terms and conditions of this Agreement.

11.2.  
Caldera shall be fully responsible for test and supply of the XRPro to its customers as well as for sourcing parts and components required for the assembly and test of the XRPro including the procurement of the M4 BIO from Bruker.

11.3.  
Caldera shall at its cost and expenses obtain all licenses, consents and sanctions from the Government of the concerned country and other authorities, agencies and bodies, necessary or required during the continuance of this Agreement for importing the M4 BIO from Bruker and the manufacture and selling of XRPro in accordance with the terms of this Agreement.

11.4.  
Neither Party to this Agreement shall be liable for any failure or delay on its part in performing any of its obligations under this Agreement or for any losses, damages, costs, charges or expenses incurred or suffered by the other Party by reason of such failure or delay, if and so far as such failure or delay shall be arising out of Force Majeure.

11.5.  
Bruker shall solely be responsible for and shall indemnify Caldera against all claims, expenses, losses and damages arising out of defects in the M4 BIO used in the assembly of the XRPro, provided that such defects are notified to Bruker in writing in accordance with Section 8.2. above, however no later than within 15 months of date of shipment of the relevant M4 BIO by Bruker.

 
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11.6.  
Caldera shall solely be responsible for and indemnify Bruker against all claims or losses incurred due to improper working of the safety features of the XRPro including any amount claimed in the event of any accident caused by such improper working of the safety features, where such improper working has occurred on account of failure of Caldera to comply with the terms and conditions of this Agreement.


12.  
Duration of Agreement, Termination

12.1.  
This Agreement shall become effective upon its signing and shall remain in force for an indefinite period of time. Either Party may terminate this Agreement without cause by giving the other Party six (6) months prior written notice.

12.2.  
Notwithstanding the provisions of Subsection 12.1., either Party is entitled to terminate this Agreement prematurely and with immediate effect for important reasons.

An important reason shall be deemed to exist, for example, if:
a)  
due to Force Majeure, or other circumstance beyond a Party's reasonable control, the Party's performance under this Agreement is hindered for more than six (6) months;
b)  
a Party violates the provisions of Section 9;
c)  
a petition is filed against a Party under the provisions of the laws of insolvency or bankruptcy;
d)  
a Party is in serious arrears with respect to its payment commitments (payments due of USD 100,000 or more after having received a reminder) or otherwise materially breaches this Agreement so that the other Party's adherence to this Agreement cannot reasonably be expected;
e)  
Caldera violates the applicable export laws and regulations (refer to Section 16).

12.3.  
Caldera shall ensure that, upon termination of this Agreement, all sub-agreements entered into by it shall be cancelled such that, to the extent feasible, they expire on the date of termination of this Agreement.

12.4.  
A notice of termination shall not give cause for any claims for damages, indemnity or compensation unless the termination is due to reasons attributable to a Party.


13.  
Assignment

The Parties agree this agreement imposes certain obligations on both Parties.  Neither Party shall assign any rights under this agreement not specifically transferable by its terms without the prior written consent of the other Party, except that each Party may, without such consent, assign this agreement and the rights, obligations and interests of such Party, in whole or in part, to any of its Affiliates so long as such Affiliate can perform that Party's obligations.


14.  
Notices

All notices which either of the Parties is required or desires to serve to the other pursuant to the terms of this Agreement shall be in writing and shall be delivered to the following addresses. Email or fax with confirmation shall be acceptable notice.
 
 
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  to Caldera : Benjamin P. Warner
    Caldera Pharmaceuticals, Inc.
    278-D DP Road
    Los Alamos, NM 87544, USA
    Tel :  +1 505 412 2345
    Fax : +1 302 347 1326
    Email: Warner@CPsci.com
     
  to Bruker: Thomas Schuelein
    Bruker Nano GmbH
    Schwarzschildstrasse 12
    12489 Berlin, Germany
    Tel :  +49 30 670 99 00
    Fax : +49 30 670 99 030
    Email: Thomas.Schuelein@bruker-nano.de
 
 
15.  
Arbitration

15.1.  
The Parties shall make a good faith effort to settle amicably any dispute or difference arising out of or resulting from this Agreement and its Annexes or ancillary agreements regarding its performance. An attempt to arrive at a settlement shall be deemed to have failed as soon as one of the Parties to the Agreement so notifies the other Party in writing.

15.2.  
If an attempt at settlement has failed, the dispute shall be resolved definitely and exclusively by the American Arbitration Association, in Chicago, Illinois, under the arbitration rules then in force. It is agreed that all documentary submissions, presentations, and proceedings shall be in the English language.

15.3.  
The arbitral award shall be substantiated in writing.  The decision of the arbitral tribunal shall be final and binding on the Parties, and judgment upon the arbitral award may be entered in any court having jurisdiction thereof. The arbitral tribunal shall assign the costs of arbitration.


16.  
Applicable Law

The contractual relations between the Parties shall be governed by the provisions of this Agreement and its Annexes and all other agreements regarding its performance, and otherwise in accordance with the substantive law in force in Delaware. The commercial clauses shall be interpreted according to the International Terms defined by Incoterms 2010..


17.  
Protection of Goodwill of Products; Compliance with Law

17.1.  
Neither party shall not make any statements, commit any acts or indulge in any business practices which might violate the laws of the United States or other countries, or injure or adversely affect the goodwill, standing or reputation of the other party or of its products.

17.2.  
Caldera hereby acknowledges that Bruker seeks to comply with all applicable laws and regulations, including the United States Foreign Corrupt Practices Act.  In furtherance of those efforts, Caldera hereby represents and warrants that, to the best of Caldera's knowledge based upon appropriate diligence and investigation:
a)  
neither Caldera nor its employees or agents has paid or contributed, and will not pay or contribute, anything of value to any governmental entity or any of its employees or agents in exchange for doing business with Caldera or Bruker; and
b)  
no contribution or payment by Caldera or any of its employees or agents in connection with this Agreement shall cause Bruker to be in violation of the United States Foreign Corrupt Practices Act, or any other applicable law or regulation.
 
 
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17.3.  
Caldera shall promptly notify Bruker if any of these representations cease to be true and accurate.  Caldera understands that if at any time it is discovered that any of the foregoing representations are incorrect, or if otherwise required by applicable law or regulation, Bruker will undertake appropriate actions to ensure compliance with the applicable law or regulation.


18.  
Written Form

Modifications of or amendments to this Agreement shall be valid only when made in writing.


19.  
Legally Void or Unfeasible Provisions

Should individual provisions of this Agreement be legally void or unfeasible, the validity of the remaining Agreement shall not be affected thereby. In such a case, the Parties shall by mutual agreement substitute for the provisions concerned a provision considered substantially equivalent in economic terms.

 
Bruker Nano GmbH            Caldera Pharmaceuticals, Inc.  
         
         
/s/ Thomas Schulein     /s/ Benjamin Warner  
Signature 
    Signature  
         
Thomas Schulein     Benjamin Warner  
Name       Name  
         
Managing Director     President  
Position     Position  
         
June 28, 2011     July 5, 2011  
Date     Date  

 
Annexes
Annex 1: M4 BIO Technical Specification and Prices
Annex 2: M4 BIO Service Price List
Annex 3: General Terms and Conditions of Bruker Nano GmbH
 
 
10

 
 
OEM Agreement Bruker – Caldera
 
ANNEX 1

XXXX






 



 




XXXX - redacted pursuant to a confidentiality request with the United States Securities and Exchange Commission
 
 
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OEM Agreement Bruker – Caldera
 
ANNEX 2

XXXX







 



 


XXXX - redacted pursuant to a confidentiality request with the United States Securities and Exchange Commission
 
 
12

 
 
ANNEX 3
 
 
GENERAL TERMS AND CONDITIONS
of Broker Nano GmbH, Germany

I. General Information

1. These General Terms and Conditions (hereinafter: GTC) of BRUKER Nano GmbH
(hereinafter: BRUKER) shall apply

a. exclusively; deviating Conditions of Purchase of the purchaser shall not be effective unless BRUKER expressly accept them; such acceptance shall he in writing if given during the phase of contract formation;
b. towards purchasers that are businesses in the sense of section 14 of the German Civil Code;
c. on all future relations between the parties, even if not agreed upon expressly.

2. BRUKER reserves all kinds of rights it has in samples, cost estimates, drawings and similar tangible and intangible items or information - also in electronic format; such items or information shall not be disclosed to any third party. BRUKER undertakes not to disclose without the consent of the purchaser any information and documents defined by the purchaser as being confidential to a   third party.

3. The respective Service Conditions of BRUKER apply additionally for assembly, commissioning, repairs, maintenance and similar services with the tariffs mentioned therein.

II. Offers

BRUKER shall revoke its offers until their acceptance unless BRUKER designates them as binding.

II. Written Form and Authorization of Employees

1. Additional or different agreements, representations or amendments have to be made in written form unless they are not made at the time of the formation of the contract. BRUKER is entitled to charge an adequate price increase for modifications made on a request of the purchaser, placed after its placement of the order.

2. Employees of BRUKER are not authorized to make oral representations in the course of the formation of the contract or agree orally upon additional clauses or amendments of the contract with the purchaser unless their authorization hereto is prescribed by law.

IV. Prices and Payment

1. Prices are valid ex works, loading within the premises included, hut packing and unloading excluded, unless otherwise agreed. Prices do not include VAT. Payment shall be considered as being made when the full amount of invoice has been credited to the account of BRUKER.

2. Payment shall be made, unless otherwise agreed, without any deduction, free BRUKER's place of payment, in the following way:

100% advance payment payable immediately upon receipt of the acknowledgement of order and - on purchaser's request - against submission of an advance payment guarantee.

3. The purchaser shall not be entitled to any right of retention or refusal or offset of his counterclaims against our claims, unless the counterclaims the purchaser exercises retention or refusal for or sets them off against our claims are uncontested or res judicata.

4. In the event the financial situation of the purchaser deteriorates considerably, jeopardizing BRUKER's claim for payment, BRUKER shall be entitled to withhold the shipment until payment has been made or sufficient securities have been provided.
 
 
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V. Delivery times and delays

1. The observance of the agreed upon delivery time by BRUKER requires that all commercial and technical questions reasonably to be clarified before delivery are clarified between the Parties and that purchaser has rendered all cooperation (for example, submission of necessary certificates from authorities or approvals of such) necessarily or reasonably to be rendered before delivery, and fulfilled all obligations to be performed in advance (for example an advance payment). Otherwise, the delivery time is prolonged correspondingly, unless BRUKER would be liable for the delay.

2. The observance of the delivery time is subject to correct and timely delivery to BRUKER by the subcontractors with which BRUKER has entered into corresponding hedgings.

3. The delivery time is met if either the goods to be delivered have left BRUKER's facility or the notification of readiness for dispatch has been sent until its expiry. In the event delivery has to be taken, the date of acceptance, or subsidiary, the collection note is decisive - except for a justified refusal to take delivery.

4. In the event dispatch or acceptance of goods is delayed for reasons the purchaser is responsible for, costs arising from the delay shall be charged to his account, starting 10 working days after the dispatch note or, respectively, collection note has been sent.

5.   Should non-compliance with the agreed-upon delivery time be caused by industrial actions or other events, arising after contract formation and beyond the control of BRUKER, delivery time shall be prolonged correspondingly unless BRUKER would be responsible for such temporary impossibility. This applies correspondingly if such events arise with subcontractors. BRUKER shall notify the purchaser of the beginning and end of such circumstances without undue delay. The prolongation of the delivery time due to such events is limited to 6 months.

VI. Default in Delivery, Partial Deliveries

1. In case of BRUKER being in default in delivery the purchaser may, in derogation of the provisions in Section X, after a waiting period of 2 weeks, charge for every completed week of delay 0.5 percent, and maximally 5 percent of the value of the part of the overall delivery which cannot be used in due time or as contractually agreed as a result of the delay, if the delay has been caused by BRUKER and a provable loss has occurred to the customer. Should purchaser assert this claim, he is excluded with further claims for damages because of the delay in delivery.

2. Should BRUKER be in delay in delivery, the purchaser may only withdraw from the contract if he set a time limit accompanied from a warning to withdraw.

3. Partial deliveries arc admissible insofar they are reasonable to the purchaser.

VII. Passing of Risk, Acceptance, Insurance

1. The risk passes - also for delivery freight paid - to the purchaser when the product has left the facility, even if partial deliveries are made or BRUKER has taken over other obligations such as, for example, shipping costs or delivery and installation.

2. Acceptance shall be performed immediately at the date of acceptance, or, if no such date is agreed upon, after dispatch note of BRUKER, unless the purchaser would be entitled to reject acceptance. Should the purchaser be entitled to reject acceptance, such rejection shall be declared without undue delay and in writing, submitting the supporting arguments.

3. In the event dispatch or acceptance is delayed or does not happen because of circumstances BRUKER is not liable for, the risk passes to the purchaser from the day of dispatch or acceptance note if passing of risk to the purchaser did not already occur earlier.

4. BRUKER will insure goods upon purchaser's specific wish and at its expense and advance payment against normal transport risks, and against such further risks the purchaser wishes them to be insured against. BRUKER may insure the goods at the purchaser expense against theft, breakage, fire, water and similar occurances even without the purchaser's request, unless the purchaser evidences having entered in such an insurance itself.
 
 
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VIII. Reservation of title

1. BRUKER reserves the title to the product until entry of all payments from the Supply Contract.

2. The purchaser may not sell the product, except such sale would occur in the ordinary course of its business. Additionally, during BRUKER's retention of title, the purchaser may not pledge or transfer the product as security. In the event of pledges and seizure or other disposal by third parties, he shall notify BRUKER immediately.

3. The purchaser herewith assigns as security to BRUKER all claims accruing from resale against another purchaser or third parties. The purchaser shall remain entitled, even after assignment, to recover debts, if he meets his financial obligations punctually and is not obliged to file for insolvency.

4. In the event of purchaser's breach of contract, included but not limited to delay in payment, BRUKER shall be entitled to take the product back after a reminder and set period of time, and the purchaser shall be obligated to return it. The assertion of the reservation of title and seizure of the product by BRUKER shall not be considered as a withdrawal from the contract with the purchaser.

5. The application for instituting insolvency proceedings shall entitle BRUKER to withdraw from the contract with the purchaser and to claim for the immediate return of the product.

IX. Warranty

BRUKER makes the following warranties for material defects in title:

Material defects

I. Purchaser has to examine the goods without undue delay and notify us in writing of any recognizable defects and shall, as far as possible with reasonable efforts, specify the defects found. At any rate, the purchaser has to examine the goods without undue delay on apparent damages in transit and report such to the transport person and BRUKER.

2. In case of a material defect that substantially reduces the suitability of the work for the contractually presupposed use, BRUKER may, at its discretion, improve or replace the delivered goods. However, if BRUKER's effort to improve or replace fails, the purchaser has the right to either reduce the price or to withdraw from the contract (rescission of contract). The exercise of the respective remedy is subject to the purchaser's prior notice hereof.

3. Should an alleged defect prove to be no defect or exclusively result from fault of the purchaser, BRUKER may claim for a service charge. Purchaser may prove BRUKER that the cost is less than what BRUKER charges. Should, however, the alleged defect prove to be a defect, BRUKER shall bear the necessary cost of improvement or replacement delivery, except the cost of the purchaser's personnel. BRUKER will bear the cost of the purchaser's personnel too, if such personnel is qualified for the disassembly/assembly of the delivered items to the same extent as BRUKER's personnel and if the purchaser has proven that additional costs for his personnel arose due to the defectiveness of the items.

4. Wearing parts are exempted from warranty.

Defects in title

5. In case the use of the product causes an infringement of industrial property rights or Copyrights, BRUKER shall procure at his expense the right of further use for the purchaser or modify the product in a way acceptable to the Purchaser and avoiding the infringement. Shouldn't this be possible with economically reasonable efforts and within an adequate period of time, the purchaser shall have the right to withdraw from the Agreement. BRUKER shall also be entitled to withdraw from the Agreement under these circumstances.
 
 
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6. BRUKER shall release the purchaser from uncontested claims or claims recognized by
declaratory judgment of the respective holder of property rights if
- the purchaser notifies BRUKER without undue delay of asserted infringements of property or copyrights,
- the purchaser assists BRUKER to a reasonable extent in rejecting asserted claims or enables BRUKER the execution of modification action in accordance with Section IX.5,
- BRUKER reserves all rejections, including settlements out of court,
- the defect in title is not based on an instruction of the purchaser and
- the infringement of a right has not been caused by the fact that the purchaser has changed the product without any authorization or used contrary to the agreement with BRUKER.

X. Liability

1. BRUKER shall be liable for purchaser's damage, irrespective of the legal grounds therefore, including but not limited to. (i) liability under tort, (ii) breach of contractual duties, and (iii) breach of duties upon contracting, only if such claims are based either on intent or gross negligence, except as otherwise provided in the following section X.2.

2. Not included under the limitation of liability pursuant to the above section X.1. are (i) claims for damages because of personal injuries, (ii) damages due to breach of material contractual obligations (“cardinal obligations”), and (iii) if purchaser relies on the due performance of our obligations due to reasons, creating a specific bond of trust recognized by law.

3. BRUKER is not liable for consequential damages, including, but not limited to lost profit, except such damages have been caused by its executive organs or managers or with intent.  In any case of liability, such liability is limited to the amount of the foreseeable damage typical to such contracts and shall as well not exceed the value of the respective order, except that the liability claim is based on intent. If BRUKER is not liable, and, insofar holds claims against third persons. BRUKER will, on purchaser's request, assign its claims against such third persons to purchaser.

4. Not included under the limitation of liability pursuant to this section X. are claims (i) under the German Product Liability Act and (ii) any other mandatory statutory liability regulations as well as claims because of (iii) misrepresentation or (iv) lack of assured characteristics or (v) our assumption of the risk of procurement of the product.

XI. Limitation of actions

Purchaser's rights resulting from breach of warranty against defects of movable property that is usually not meant to be used for a building, are subject to a limitation period of 12 months, in derogation of sections 438 para 1 No. 3 and 634a para 1 No. I of the German Civil Code. All further claims of purchaser - for whatever legal grounds - are subject to a limitation period of 12 months too, except such claims are based on intentional or fraudulent behavior of BRUKER or on the Product Liability Act.

XII. Software use

As far as software is contained in the scope of delivery, the purchaser shall be granted a nonexclusive right to use to software delivered including its documentation. The use on the specific product is permitted. Use of the software on more than one system is prohibited. The purchaser may reproduce, revise, translate the software or convert from object code to source code only to the extent permitted by law (sections 69a - 69f of the German Copyright Act). The purchaser is obligated not to remove manufacturer's data, especially copyright notes, or change them without BRUKER's prior express consent.
All other rights related to the software and documentation including copies remain with BRUKER or the software supplier. Granting of sub-licenses is not admissible.

XIII. Miscellaneous, Applicable Law, Place of Jurisdiction

1. All legal relations between BRUKER and Purchaser are exclusively subject to the law of the Federal Republic of Germany.

 
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2. Place of jurisdiction is the court Karlsruhe, Germany. BRUKER is, however, entitled, to take legal action at the purchaser's seat. Both parties shall reserve the right to finally settle possible disputes ousting the jurisdiction of a court in accordance with the Rules of Arbitration of the German Institution for Arbitration (DIS).

XIV. Representation of Integrity

1. BRUKER complies with the German and U.S. laws against corrupt practices and requires the same from the purchaser.

2. The purchaser guarantees in the sense of a guarantee pursuant to Section 311 para 1 of the
German Civil Code that (a) no one of its managing directors, holders of a special statutory authority, other representatives or employees has paid or contributed, or will pay or contribute, anything of any material value to any customer, governmental entity or governmental employees or agents in exchange for doing business with the purchaser, and that (b) he will strictly comply with the German and U.S. laws against corrupt practices.

Version: July 01, 2010
 
 
 
 
 
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  Exhibit 21.1


Caldera Pharmaceuticals, Inc., a Delaware Corporation

Listing of Subsidiaries

XRpro Corp, a Nevada corporation

 


 
 
Exhibit 23.1
 

INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM CONSENT
 
We consent to the use in this Registration Statement on Form S-1, for Caldera Pharmaceuticals, Inc. of our report dated February 13, 2012, relating to the consolidated balance sheets of Caldera Pharmaceuticals, Inc. as of December 31, 2010 and 2009, and the related consolidated statements of operations, stockholders’ deficit and cash flows for the years ended December 31, 2010 and 2009. We also consent to the reference to us under the heading "Experts" in such Registration Statement.
 
 
/s/ Sherb & Co., LLP
 
Boca Raton, Florida
February 14, 2012