Caldera Pharmaceuticals Inc (Form: S-1/A, Received: 04/20/2012 17:32:27)

-10-

Limitations on director and officer liability and indemnification of our Company’s officers and directors by us may discourage stockholders from bringing suit against an officer or director.

Our Company’s certificate of incorporation and bylaws provide, with certain exceptions as permitted by governing state law, that a director or officer shall not be personally liable to us or our stockholders for breach of fiduciary duty as a director or officer, except for acts or omissions which involve intentional misconduct, fraud or knowing violation of law, or unlawful payments of dividends. These provisions may discourage stockholders from bringing suit against a director or officer for breach of fiduciary duty and may reduce the likelihood of derivative litigation brought by stockholders on our behalf against a director or officer.

We are responsible for the indemnification of our officers and directors.

Should our officers and/or directors require us to contribute to their defense, we may be required to spend significant amounts of our capital. Our certificate of incorporation and bylaws also provide for the indemnification of our directors, officers, employees, and agents, under certain circumstances, against attorney's fees and other expenses incurred by them in any litigation to which they become a party arising from their association with or activities on behalf of our Company. This indemnification policy could result in substantial expenditures, which we may be unable to recoup. If these expenditures are significant, or involve issues which result in significant liability for our key personnel, we may be unable to continue operating as a going concern.

The rights of our preferred stock could negatively affect holders of common stock and make it more difficult to effect a change of control.

Our board of directors is authorized by our charter to create and issue preferred stock. Certain of the rights of holders of preferred stock take precedence over the rights of holders of common stock. We are authorized to issue 10,000,000 shares of preferred stock, of which 400,000 are designated as Series A Preferred Stock . We have issued 341,607 shares of Series A preferred stock. The holders of the Series A preferred stock are entitled to a dividend of $.46 per share each year payable in cash or stock at the option of the holder and is entitled to a preference upon our liquidation, dissolution or winding up. The shares are convertible voluntarily at the election of the holder and automatically ten trading days after delivery to the holder by us of a notice that the volume-weighted average closing price of our common stock over the ten trading days immediately preceding the date of notice is at least $10.00 per share. The holders are also entitled to registration rights with respect to such shares. We may issue additional shares of Series A preferred stock in addition to other preferred stock. As future tranches of capital are received by the Company, additional preferred stock may be issued which such terms and preferences as are determined in the sole discretion of our board of directors. The rights of future preferred stockholders could delay, defer or prevent a change of control, even if the holders of common stock are in favor of that change of control, as well as enjoy preferential treatment on matters like distributions, liquidation preferences and voting.

Our common stock may be thinly traded, so you may be unable to sell at or near ask prices or at all if you need to sell your shares to raise money or otherwise desire to liquidate your shares.

Prior to this offering, you could not buy or sell our common stock publicly. We cannot predict the extent to which investors’ interests will lead to an active trading market for our common stock or whether the market price of our common stock will be volatile following this offering. If an active trading market does not develop, investors may have difficulty selling any of our common stock that they buy. There may be limited market activity in our stock and we are likely to be too small to attract the interest of many brokerage firms and analysts. We cannot give you any assurance that a public trading market for our common stock will develop or be sustained. If we trade on OTC markets, the trading volume we will develop may be limited by the fact that many major institutional investment funds, including mutual funds as well as individual investors, follow a policy of not investing in OTC stocks and certain major brokerage firms restrict their brokers from recommending OTC stocks because they are considered speculative, volatile, thinly traded and the market price of the common stock may not accurately reflect the underlying value of our Company. The market price of our common stock could be subject to wide fluctuations in response to quarterly variations in our revenues and operating expenses, announcements of new products or services by us, significant sales of our common stock, including “short” sales, the operating and stock price performance of other companies that investors may deem comparable to us, and news reports relating to trends in our markets or general economic conditions.

-11-

Table of Contents

The application of the “penny stock” rules to our common stock could limit the trading and liquidity of the common stock, adversely affect the market price of our common stock and increase your transaction costs to sell those shares.

As long as the trading price of our common stock is below $5 per share, the open-market trading of our common stock will be subject to the “penny stock” rules, unless we otherwise qualify for an exemption from the “penny stock” definition. The “penny stock” rules impose additional sales practice requirements on certain broker-dealers who sell securities to persons other than established customers and accredited investors (generally those with assets in excess of $1,000,000 or annual income exceeding $200,000 or $300,000 together with their spouse). These regulations, if they apply, require the delivery, prior to any transaction involving a penny stock, of a disclosure schedule explaining the penny stock market and the associated risks. Under these regulations, certain brokers who recommend such securities to persons other than established customers or certain accredited investors must make a special written suitability determination regarding such a purchaser and receive such purchaser’s written agreement to a transaction prior to sale. These regulations may have the effect of limiting the trading activity of our common stock, reducing the liquidity of an investment in our common stock and increasing the transaction costs for sales and purchases of our common stock as compared to other securities. The stock market in general and the market prices for penny stock companies in particular, have experienced volatility that often has been unrelated to the operating performance of such companies. These broad market and industry fluctuations may adversely affect the price of our stock, regardless of our operating performance. Stockholders should be aware that, according to Securities and Exchange Commission (“SEC”) Release No. 34-29093, the market for penny stocks has suffered in recent years from patterns of fraud and abuse. Such patterns include: (i) control of the market for the security by one or a few broker-dealers that are often related to the promoter or issuer; (ii) manipulation of prices through prearranged matching of purchases and sales and false and misleading press releases; (iii) boiler room practices involving high-pressure sales tactics and unrealistic price projections by inexperienced sales persons; (iv) excessive and undisclosed bid-ask differential and markups by selling broker-dealers; and (v) the wholesale dumping of the same securities by promoters and broker-dealers after prices have been manipulated to a desired level, along with the resulting inevitable collapse of those prices and with consequent investor losses. The occurrence of these patterns or practices could increase the volatility of our share price.

We may not be able to attract the attention of major brokerage firms, which could have a material adverse impact on the market value of our common stock.

The trading market for our common stock will rely in part on the research and reports that equity research analysts publish about us and our business. We do not control these analysts. However, security analysts of major brokerage firms may not provide coverage of our common stock since there is no incentive to brokerage firms to recommend the purchase of our common stock, which may adversely affect the market price of our common stock. If equity research analysts do provide research coverage of our common stock, the price of our common stock could decline if one or more of these analysts downgrade our common stock or if they issue other unfavorable commentary about us or our business. If one or more of these analysts ceases coverage of our company, we could lose visibility in the market, which in turn could cause our stock price to decline.

USE OF PR O CEEDS

We will not receive any proceeds from the sale of the common stock by the selling security holders pursuant to this prospectus. All proceeds from the sale of the shares will be for the account of the selling security holders. We will receive net proceeds from the exercise of the warrants to purchase shares of our common stock covered by this prospectus which would total $2,221,119 if all the warrants were exercised for cash. We intend to use the proceeds received from the exercise of warrants for general working capital purposes, including for the payment of marketing and personnel expenses.

BUSIN ES S

We were incorporated in the State of Delaware on November 12, 2003. On March 14, 2011, the Company filed a First Amended and Restated Certificate of Incorporation with the Secretary of State of Delaware increasing the authorized common shares from 10,000,000 to 50,000,000 and the issuance of up to 10,000,000 preferred shares. Subsequently, we filed a Second Amended and Restated Certificate of Incorporation on April 10, 2012 , which designated 400,000 of our 10,000,000 shares of preferred stock as Series A preferred stock. See “Risk Factors – The rights of our preferred stock could negatively affect holders of common stock and make it more difficult to effect a change of control.” The Company has reserved up to 3,000,000 shares for issuance to employees, directors and others in accordance with the terms of our 2005 Stock Option Plan.

History

Caldera was founded by Dr. Benjamin Warner in 2003 at the request of the then director of Los Alamos National Laboratory (“LANL”) for the purpose of commercializing previous work done by Dr. Warner at LANL regarding the use of x-ray fluorescence to measure the chemical composition of pharmaceuticals. Dr. Warner earned his PhD in Chemistry from the Massachusetts Institute of Technology (“MIT”) in 1995. After MIT, Dr. Warner joined LANL where he held various positions including the position of Project Leader for National Security Programs from 2000 until 2004.

-12-

Table of Contents

While at LANL, Dr. Warner patented through the auspices of the University of California (then the manager of LANL) his improvement to x-ray fluorescence technology that allowed it to be used to measure nanograms of material. This improvement made x-ray fluorescence economically feasible to measure the chemical composition of pharmaceuticals.

Dr. Warner has won numerous awards from Los Alamos National Laboratory for his commercialization and patenting work, including the Distinguished Licensing Award, the Distinguished Entrepreneurial Award, the Distinguished Patent Award, and the Federal Laboratory Consortium Distinguished Service Award. Jointly with LANL, Caldera Pharmaceuticals won the 2007 Federal Laboratory Consortium Award for Excellence in Technology Transfer and an R&D100 Award. Caldera has won multiple Technology Ventures Corporation awards for top technology companies in New Mexico.

LANL is a United States Department of Energy national laboratory. LANL is managed and operated by Los Alamos National Security, LLC (LANS), a private limited liability company formed by the University of California , Bechtel , Babcock & Wilcox Technical Services , and URS Energy and Construction . LANL is one of the largest science and technology institutions in the world. It conducts multidisciplinary research in national security, space exploration, renewable energy, medicine, nanotechnology, supercomputing and other disciplines. LANL’s mission is to develop and apply science and technology to ensure the safety, security, and reliability of the U.S. nuclear deterrent; reduce global threats; and solve other emerging national security challenges. LANL is the largest institution in Northern New Mexico with more than 9,000 employees plus approximately 650 contractor personnel and an annual budget of approximately $2.2 billion.

Our Current and Future Business

We are a research and development firm engaged in various aspects of drug discovery. The cornerstone of our business is our unique technology that is based on direct chemical analysis of protein-drug combinations by means of micro X-ray fluorescence spectroscopy. We currently offer our customers analytical services using our technology to evaluate drug candidates for safety and efficacy. We believe that our technology can reduce the cost of drug discovery by detecting safety and efficacy issues at an early stage of development. To date, substantially all of our revenue has been derived from our analytical services that we have performed for United States governmental agencies. However, we expect that our future revenue will be derived from three lines of business: (i) provision of our analytical drug discovery services; (ii) sale of our drug discovery instruments; and (iii) sale of new drug candidates that we identify using the XRpro® drug discovery instruments that we are currently developing and commercialization. We intend to expand our customer base to begin providing our analytical services to biotechnical and pharmaceutical customers in addition to the government sector. We have developed a stand-alone unit, of our XRpro® drug discovery instrument that can be sold to customers, such as pharmaceutical and biotech companies that would allow them to use our technology to conduct the same analytical services that we provide for the United States government. We also anticipate deriving revenue from the sale or licensing of drug candidates that we discover when conducting our chemical analysis.

To date we have been granted nineteen (19) contracts from governmental agencies, of which nine (9) were granted from the Department of Defense and ten (10) were granted from the National Institutes of Health. Of such contracts, seventeen (17) have been completed and we received payment in full for all seventeen (17) completed contracts. All contracts contained standard terms, including termination provisions which allow for the government to terminate the contract, in whole or in part, at any time for convenience with payment in such circumstances in the discretion of the governmental agency. The contracts also contain Bayh-Dole and related provisions for disposition of intellectual property. Set forth below are the details of the two contracts under which we are still providing services to the National Institutes of Health and are expected to receive $2,902,062 for such services.

1.	Contract 2R44AI079935-03 with the National Institutes of Health; to develop strontium-selective therapies, contract amount: $3,000,000.00, operative from 08/24/2011 - 07/31/2014, $184,954.01 paid to date, $2,815,045.99 remaining in contract.

2.	Contract 1R43GM090387-01 with the National Institutes of Health; to develop assays for carcinogens, contract amount: $200,000.00, operative from 08/06/2010 - 08/05/2012, $112,982.86 paid to date, $87,017.14 remaining in contract.

XRpro® Drug Discovery Services

We currently derive substantially all of our revenue from the provision of our analytical drug discovery services to the federal government. The Company believes that due to the unique properties of its technology there is the potential to expand its customer base to include private enterprises, such as pharmaceutical companies which conduct large-scale research and development of new drug candidates. As a result, the Company plans to expand its outsourced drug discovery and screening services to include a larger customer base, primarily targeting pharmaceutical companies.

XRpro® Drug Discovery Instruments

The XRpro® instrument is a high-throughput x-ray fluorescence microscope. In July 2011, we entered into an exclusive contract with Bruker Nano GmbH, a German company engaged in the manufacture and sale of components and systems for micro and nanoanalysis of electron microscopes, to customize its desk top analyzer by incorporating our improvements and intellectual property into its already existing product. The agreement is for an indefinite term but may be terminated by either party without cause upon six months notice or immediately upon the happening of certain events, including bankruptcy, violation of export laws and nonpayment of commitments of $100,000 or more. The agreement includes a non-competition provision specifying that we cannot copy the product manufactured by Bruker and that Bruker will not sell such product to any third party or end user that competes with us.

We have not sold or leased any XRpro® instruments and to date no one other than us has used the XRpro® instruments to perform analytical services ; however, we have begun initial, limited marketing of the XRpro® instrument. Until such time as we have indications of increased market acceptance of our product and increased financial resources we do not anticipate expending large sums of money on a sales force for our product or marketing efforts. Although the Company has not shipped XRpro® instruments to the private sector, we believe that use of the XRopro instrument can demonstrate significant cost savings by allowing pharmaceutical companies to combine multiple safety and efficacy tests in the drug discovery process at a price substantially lower than current industry standards without the need to modify the drug, protein, or cell, or use expensive reagents.

New Drug Candidates

Often when we conduct our chemical analysis of molecules for safety and efficacy in accordance with government funded research, we discover new drug candidates. We have developed new molecules including new MRI contrast agents, radiopharmaceuticals, anti-infectives, and therapies for heavy metal toxicity. These chemicals have been developed using our XRpro® technology and have been tested using in vitro safety and efficacy models. We plan to further develop these molecules as far as possible using Federal contracts and grants that pay for substantially all the research and development costs and either sell them or license them to third parties who will apply for FDA approval of such drugs . We obtained a $3,000,000 grant in August 2011 from the National Institutes of Health/ National Institute for Allergies and Infectious Diseases to conduct animal trials for one of our drug candidates, which is a therapy for exposure to radioactive strontium .

-13-

Table of Contents

Our Analysis Technology

Our XRpro® technology quantifies drug/protein interactions without the need to modify the drug, protein, or cell, or use expensive reagents. Many technologies require that expensive reagents (substances that are added to a system in order to bring about a chemical reaction or is added to see if a reaction occurs) or “labels” be used to measure the properties of drug candidates during the drug discovery process. These reagents are expensive, and can introduce experimental errors, wasting billions of dollars each year. Label-free technologies are particularly sought by the pharmaceutical industry because it is believed that they provide superior data at lower cost. Our high-throughput XRpro® technology measures approximately 2,000,000 compounds per month. Our technology measures multiple parameters for both drugs and proteins. This allows, for example, the ability to measure multiple interactions between a single drug and multiple proteins in a single measurement. We therefore measure on-target (i.e., efficacy) and off-target ( i.e. side effects/toxicity) properties simultaneously.

Our high-throughput XRpro® technology does not require the use of expensive reagents, chemical dyes or radiological labels, which are commonly required for competing techniques. The use of a reagent in the analysis process, for a typical high-throughput campaign, can typically cost $0.50 or more per compound . Based on such costs, we believe that our XRpro® technology saves the customer approximately $500,000 per month for a typical high-throughput screening rate of 1,000,000 compounds per month.

We believe that our ability to provide our services in a cost and time efficient manner will allow us to profitably offer and expand our XRpro® drug discovery services to biotech and pharmaceutical companies as well as to cost-effectively continue our development of new drug candidates.

Scientific Advantages of XRpro ®

The pharmaceutical industry uses assays to measure the properties of experimental medicines. XRpro® allows multiple assays to be conducted at significantly lower costs than existing techniques. XRpro® assays include:

•	Functional Assays, or to what extent a drug inhibits a protein target;

•	Binding Assays, or whether a drug binds to a protein;

•	Cell Assays, such as whether a drug acts upon a cell model for a disease;

•	Ion Channel Assays, or whether a drug inhibits hERG protein, which is associated with cardiotoxicity;

Some of the key features of XRpro® are the following:

•	Price of the instrument - XRpro® is priced similar to other instruments that have large monthly reagent or label costs;

•	Monthly costs - XRpro® dramatically reduces costs by eliminating the need for reagents, antibodies and labels, allowing savings of approximately $500K per month;

•	Fast -. XRpro® currently runs at a rate of 2,000,000 measurements per month;

•	Sensitive - XRpro® measures nanograms of material, which has allowed us to reduce protein consumption tenfold in some cases;

•	Precise - XRpro® has demonstrated Z-Factors, which are a common measurement of assay precision, above 0.8. This is roughly equivalent to 12 standard deviations between an assay and a blank;

•	Durable - XRpro® allows samples to be read dry, months after assay, in contrast to most competing assays which must be read wet, and shortly after the assay was run; and

•	Data Rich - XRpro® allows simultaneous on-target and cross-target functional assays, which gives an estimate of both safety and toxicity.

The underlying science of XRpro® is similar to the more commonly used optical fluorescence. In optical fluorescence, light having energy of 2-3 electron volts (eV) is shone on a sample, which then emits another wavelength of light. The amount of light that is emitted and its wavelength provide information about what chemicals are present, and in what quantities. In optical fluorescence, the fluorophore, or potion of the molecule that emits light, is large and often expensive.

XRpro®, on the other hand, uses x-rays, which have different properties than the light used in optical fluorescence. The most important of these properties is that the portion of the molecule that emits photons is an atom. XRpro® directly quantifies atoms that are present in many drugs, proteins, and functional assays. This feature is what produces the huge cost savings of XRpro®.

Market

According to a March 16, 2010 article published by www.phrma.org , analyses performed by the Pharmaceutical Research and Manufacturers of America (PhRMA), which represents many pharmaceutical research and biotechnology companies, and Burrill & Company, a global financial services firm focused on the life sciences industry, US pharmaceutical companies invested $67.4 billion in 2010 in the research and development of medicines and vaccines. Further, global R&D spending is expected to grow by about 5.2% to more than $1.4 trillion in 2012, according to the 2012 Global R&D Funding Forecast published by Battelle, an independent research and development organization. According to Battelle, most of the global funding growth is being driven by Asian economies, which are expected to increase nearly 9% in 2012, while European R&D will grow by about 3.5% and North American R&D by 2.8%. U.S. R&D is forecast to grow 2.1% in 2012 to $436 billion.

According to PhRMA, only one of every 10,000 potential medicines investigated by America's research-based pharmaceutical companies makes it through the research and development pipeline and is approved for patient use by the Food and Drug Administration (FDA). On average, according to PhRMA, approval requires 15 years of R&D and costs more than $1 billion. Potential new medicines pass through several crucial stages on their way from research laboratories to the pharmacy shelf. These stages begin with discovery , which includes determining the biological mechanism to treat an illness, and creating and testing chemicals to counteract that mechanism of the illness. The next stage is preclinical development , which includes creating and testing hundreds of chemical analogs of the chemicals identified in discovery to identify those chemicals that are both safe and effective enough to test in human volunteers. The final stage before approval is clinical trials , which includes testing the medicine on volunteers for safety and then efficacy. Our proprietary XRpro® technology focuses on the preclinical stage. We believe that the XRpro® will significantly reduce the costs of preclinical tests, and allow multiple tests to be performed simultaneously, reducing the time and costs required to evaluate drug candidates for safety and efficacy.

-14-

Table of Contents

According to research data collected by Frost & Sullivan, an international marketing and growth consulting firm, worldwide revenue for all laboratory products reached $36.2 billion in 2010, and the US laboratory products market was approximately $13.7 billion in 2010. Instruments and equipment comprise about one-third of this market, and chemicals and reagents comprise about one quarter of this market. The overall marketplace in which the Company’s XRPro® drug discovery instruments and XRpro® drug discovery services competes is therefore approximately $8 billion per year in the US alone.

Competition

The life sciences research market is very competitive and includes a number of companies, such as Affymetrix Agilent Technologies Inc., Bio-Tek Instruments, Inc., Danaher, ForteBio (acquired by Pall), GE Healthcare, Illumina, PerkinElmer, Spectris, Tecan Group Ltd. and Thermo Fisher Scientific, that offer, or may in the future offer, products with performance capabilities generally similar to those offered by our products. We expect that competition is likely to increase in the future, as several current and potential competitors who have the technological and financial ability to enter the markets that we serve enter the markets. Many of our life sciences research products are priced at a premium; in these markets, we compete primarily on the basis of performance and productivity. Many companies, research institutions and government organizations that might otherwise be customers for our products employ methods for analysis that are internally developed.

Many of our competitors have significantly greater financial, technical, marketing, sales and other resources than we do. In addition to competing with us with respect to product sales, these companies and institutions compete with us in recruiting and retaining highly qualified scientific and management personnel.

We offer what we believe to be a superior technology to measure the properties of drug candidates. Our major competing technology is drug labeling which is currently the most used technique for measuring the binding of drugs to proteins. While commonly used, it produces results of inconsistent reliability because of the added reagents that can bias the test results, thereby diminishing the value of test. Companies providing these technologies include DiscoveRx, PerkinElmer and Promega.

Another competing technology is surface plasmon resonance. This technology moves the label from the drug to the protein, which partially – but not completely – mitigates the reliability problems. The label on the protein often interferes with protein function. It is also expensive and currently not very high-throughput. Companies providing SPR include GE Healthcare, SRU, Graffinity and Corning.

A final group of potential competitors may be companies that manufacture X-Ray fluorescence equipment based upon similar technology to ours that also does not require the use of any reagents. These include EDAX, Horiba and PANalytical. We believe that our intellectual property portfolio and our partnership with Bruker place us in a favorable position in relation to these potential competitors.

Intellectual Property Rights

In September 2005, we entered into an agreement with The Regents of the University of California which was subsequently assigned to the Los Alamos National Security, LLC in conjunction with the selection by the Department of Energy and the National Nuclear Security Administration for a new contract providing that Los Alamos National Security, LLC would replace The Regents of the University of California in the management and operation of the Los Alamos National Laboratory. The license grants to us the exclusive right to hold, use and sell inventions under a portfolio of issued patents and pending patents for our current technology, a method for detecting binding constants using micro x-ray fluorescence. The University retained the right to use the technology for noncommercial purposes and the United States government has a nonexclusive license to have practiced the technology. In accordance with the Bayh-Dole Act and similar laws, small businesses, such as ours, can retain title to federally funded inventions if we follow certain procedures, including filing for patent protection and actively pursuing commercialization of the invention, and the U.S. government retains a non-exclusive, non-transferable, paid up irrevocable license, throughout the world, with respect to the invention. In addition, the U.S. government also retains a march in right that allows it to license the invention to third parties, without our consent, if it determines that the invention is not being made available to the public on a reasonable basis. We also agreed to allow the University to use all improvements on the technology developed by us. The agreement was effective upon execution and terminates after the expiration of the last patent unless terminated earlier. The agreement provides that the University can terminate the agreement if, after a 60 day cure period, we fail to deliver any required reports, make any required payments or if we breach any material terms of the agreement. It also provides for immediate termination upon receipt of a notice of our filing of a bankruptcy petition. We have the right to terminate the agreement upon 90 days notice; however a termination does not relieve us of any payment or other obligations that were already due. Upon execution of the agreement we paid a $40,000 upfront nonrefundable fee, in addition to our issuance of shares of our common stock representing three percent (3%) of our outstanding equity, which was later assigned by the University to Los Alamos National Security LLC. Such stock is nondilutable and the holder has the right to publicly sell shares if we complete an initial public offering. We are also obligated to make annual payments to the University of $25,000 each year until 2011 and then $50,000 until 2020, and royalty payments of 2% of Net Sales (as defined in the agreement), additional fees on sublicensed revenue and $20,000 per each United States patent that is issued. Under the license, Caldera has the exclusive commercial rights to a set of patents, patent applications, and any divisional and continuation patents, including those listed below. The license is exclusive through the expiration of these patents and patent applications, which are expected to expire between May 2021 and June 2024:

Licensed Patents and Patent Applications

1. US Patent 7,858,385, Method for detecting binding events using micro-X-ray fluorescence spectrometry, expires May 16, 2021

2. US Patent 7,241,381, Method and apparatus for detecting chemical binding, expires July 16, 2023

3. US Patent 6,858,148, Method and apparatus for detecting chemical binding, expires July 16, 2023

4. US Patent Application 20040235059, Drug development and manufacturing, ( patent pending )

-15-

Table of Contents

We have filed the following published patent applications to further buttress our intellectual property position:

1.	US Patent Application 20100003697, Method and Apparatus for Measuring Analyte Transport Across Barriers

2.	US Patent Application 20090087919, Method and Apparatus for Measuring Protein Post-Translational Modification

3.	US Patent Application 20090046832, Well Plate

4.	US Patent Application 20080220441, Advanced drug development and manufacturing (jointly filed and owned with Los Alamos National Security, LLC)

We continue to file additional patent applications periodically.

Employees

As of February 1, 2012, the Company employs seven full-time employees and two part-time employees. None of our employees are subject to collective bargaining agreements.

Backlog

We do not have any material order backlog as of the date of this registration statement.

Seasonality

We do not expect that our business will experience significant seasonality.

Property

We lease approximately 5,160 square feet at 278 DP Road, Suite D, Los Alamos, New Mexico 87544, where our corporate offices and laboratory are located under the terms of two leases . Each lease is for a term of 36 months with a six month termination clause, which commenced in November 2010. The leases provide for an aggregate annual rent of approximately $58,607 for the first year of the leases with an increase each year thereafter of three percent (3%) of the prior year’s rent. The current aggregate monthly rental payments including utilities and operating expenses for the facilities are approximately $6,000 per month. We believe these facilities are in good condition and adequate to meet our current and anticipated requirements.

Legal Proceedings

Los Alamos National Security Suit

In October 2010, the Company filed suit against Los Alamos National Security LLC (“LANS”) and seven other co-defendants in the United States District Court For the Northern District of Illinois Eastern Division alleging the following: (i) Breach of Contract; (ii) Fraud; (iii) Intentional Interference with Contractual Relations; (iii) Legal Malpractice; and other related claims in connection with an exclusive Patent Licensing Agreement (the “Agreement”) originally entered into between the Company and the Regents of the University of California (the “Regents”) in September 2005. In April 2006, the Regents assigned the Agreement to LANS. The Company believes the defendants made false representations that were critical to its decision to enter into the Agreement including: (i) the Regents was the lawful owner of the patent rights covered by the Agreement; and (ii) the Regents would prosecute and maintain these patent rights and notify the Company if it decided to abandon them. The Company also believes that LANS and other co-defendants improperly competed with the Company. In addition, the Company believes that two of the co-defendants, both in-house patent attorneys for LANS, breached their professional duties. The Company believes it has suffered substantial damages from the defendants’ actions. The Company also filed suit against the Regents and LANS in California Superior Court in San Francisco in December 2007. This suit was dismissed for reason of lack of subject matter jurisdiction by the Court. We believe that this dismissal was made incorrectly, and are appealing this ruling. The defendants filed countersuits, which were also dismissed. Should LANS or other defendants file or re-file countersuits, the Company intends to vigorously defend itself. In January 2012, this case was ordered to be transferred to Federal Court in New Mexico. In February 2012, the case was transferred to Federal Court in New Mexico.

-16-

Table of Contents

In September 2011, the Company filed suit against the Regents of the University of California and LANS in the Circuit Court of Cook County. LANS removed the case to federal court, Case # ll-CV-07259. The Company's complaint alleges the following: (i) Breach of Contract; (ii) Breach of the Implied Covenant of Good Faith; (iii) Fraud; and (iv) Fraudulent Inducement, in connection with an exclusive Patent Licensing Agreement (the "Agreement") originally entered into between the Company and the Regents of the University of California (the "Regents") in September 2005 and assigned to LANS in April 2006. The Company believes the defendants breached a License Agreement, and made false representations that were critical to the Company's decision to enter into the Agreement. The Company believes it has suffered substantial damages from the Defendants' actions. In March 2012, the Company filed a motion to remand the case to the Circuit Court of Cook County. To date, we have spent a total of $689,146 with respect to this case, of which $257,801 was spent during the year ended December 31, 2011 and $40,000 has been spent in 2012.

Seddie Bastanipour and Joel Bellows Suit

In October 2008, Seddie Bastanipour and Joel Bellows filed suit against the Company, our Chief Executive Officer, Dr. Benjamin Warner, and a former consultant to the Company, Sigmund Eisenchenk. Joel Bellows provided legal services to the Company through his legal firm, Bellows and Bellows P.C. The suit was filed in the Circuit Court of Cook County, Illinois and alleged the following: (i) Violation of Illinois Securities Act of 1953; (ii) Violation of Illinois Consumer Fraud Act; and (iii) Common Law Fraud, in connection with aggregate investments of $218,000 in the Company’s common stock claimed by Bastanipour and Bellows. They are seeking compensatory damages, costs and expenses. The Company does not believe Bellows will prevail on any of the alleged complaints. In December 2011, the Company completed an amicable settlement with Bastanipour.

In March, 2010, the Company filed suit against Joel Bellows and Bellows and Bellows P.C. in the United States District Court for the District of New Mexico alleging the following: (i) Breach of Contract; (ii) Negligence; (iii) Breach of Fiduciary Duty; (iv) Fraud; and (v) Tortious Interference with Contract. The aforementioned complaints relate to legal services provided by Bellows and Bellows P.C. for the Company. The Company is seeking compensatory damages, punitive damages, interest, costs and fees.

In December 2010, the Company filed suit against Seddie Bastanipour and Peter Baltrus for breach of contract and negligence when they were performing accounting services on behalf of the Company which resulted in an IRS penalty. In December 2011, the Company completed an amicable settlement with Bastanipour that is subject to confidentiality restraints and she is no longer party to either suit. The settlement did not have a material impact on our financial position . Baltrus claims to have been working for Bellows (see above) at all relevant times; the case against Peter Baltrus continues. The Company has entered into further settlement discussions with Peter Baltrus. To date, we have spent a total of $678,701 with respect to this case, of which $425,604 was spent during the year ended December 31, 2011 and $47,570 has been spent in 2012.

Holders

As of April 15 , 2012, there were approximately 72 stockholders of record of our common stock.

Dividends

We have never declared or paid a cash dividend for common stock. Any future decisions regarding dividends will be made by our board of directors. However, our Series A preferred stockholders are entitled to an annual dividend of $.46 per share of preferred stock payable in cash or stock at the option of the holder. We currently intend to retain and use any future earnings other than those paid to Series A preferred holders as dividends for the development and expansion of our business and do not anticipate paying any cash dividends in the foreseeable future. Our board of directors has complete discretion on whether to pay dividends on our common stock. Even if our board of directors decides to pay dividends on our common stock, the form, frequency and amount will depend upon our future operations and earnings, capital requirements and surplus, general financial condition, contractual restrictions and other factors that the board of directors may deem relevant.

Equity Compensation Plans

In 2005 our board of directors adopted the 2005 Stock Option/Stock Issuance Plan (the “Plan”) that was approved by a vote of the majority of our shareholders. The Plan is intended to promote the interests of our Company by providing eligible person s with the opportunity to acquire a proprietary interest, or otherwise increase their proprietary interest, in the Company as an incentive for them to be employed by or remain in the service of the Company. The Plan provides for issuance of incentive stock options or nonqualified stock options. The maximum number of shares available to be issued under the Plan is currently 3,000,000 shares, subject to adjustments for any stock splits, stock dividends or other specified adjustments which may take place in the future and there are currently 518,445 options issued and outstanding. The Plan continues until the earlier of termination by the board of directors or when all shares of common stock available for issuance has been issued and all restrictions on such shares under the terms of the Plan have lapsed.

-17-

Table of Contents

The Plan is administered by our Company’s board of directors. Persons eligible to participate in the Plan are: employees; officers, directors, consultants, investors, and service providers to our Company. All grants under the Plan are intended to comply with the requirements under Internal Revenue Code and activities under the Plan will be administered accordingly. Options granted under the Plan are evidenced by agreement between the recipient and our Company, subject to the following general provisions: (i) the exercise price shall not be less than 100% of the fair market value per share of our Company’s common stock on the date of grant (110% in the case of 10% or greater shareholders); and (ii) the term of stock options shall be limited to a maximum of ten years. A complete description of the Plan is included as an exhibit to this registration statement.

DETERMINATION OF OFFERING PRICE

Prior to this offering, there has been no public market for our securities. The initial offering price of $5.00 per share, which will be in effect until the shares are quoted, if ever, on the OTC Bulletin Board or another exchange, was determined by evaluating our recent sales of unregistered securities. Factors considered in determining such price in addition to prevailing market conditions include recent sales of securities and an assessment of our future prospects. Such price does not have any relationship to any established criteria of value, such as book value or earnings per share. Such price is not indicative of the current market value of our assets. No valuation or appraisal has been prepared for our business. No assurance can be given that the shares can be resold at the public offering price.

DILUTION

If you purchase common stock offered in this offering at the stated offering price of $5.00 per share, you will experience an immediate and substantial dilution in the projected net tangible book value of the common stock from the price you pay in this offering. The net tangible book deficit of our common stock as of December 31, 2011 was ($109,748), or ($0.03) per share of common stock. Net tangible book deficit per share is equal to our total tangible assets, less total liabilities, excluding derivative financial liabilities of $600,000, divided by the number of shares of common stock outstanding plus shares underlying convertible securities, such as options and warrants, held by officers, directors and affiliated persons and exercisable within 60 days of the statement date. This total potential outstanding number of common shares is 4,341,690 at December 31, 2011.

This means that if you buy stock offered in this offering at $5.00 per share, you will pay substantially more than the average price our current common shareholders paid for their shares.

SECURITIES AUTHORIZED FOR ISSUANCE UNDER EQUITY COMPENSATION PLANS

The following table provides information regarding the status of our existing equity compensation plans at April 15 , 2012.

	Number of securities to be issued upon exercise of outstanding options, warrants and rights		Weighted-average exercise price of outstanding options, warrants and rights		Number of securities remaining available for future issuance under equity compensation plans

Equity compensation plans approved by security holders		518,445		3.54		2,481,555

Equity compensation plans not approved by security holders		0		0		0

Total		518,445		3.54		2,481,555

The number of securities remaining available for future issuance under equity compensation plans approved by security holders totaled 2,481,555 shares at April 15 , 2012.

MANAGEMENT'S DISCUSSION AND AN ALYS IS OF FINANCIAL CONDITION AND RESULTS OF OPERATIONS

The following discussion and analysis is intended as a review of significant factors affecting our financial condition and results of operations for the periods indicated. The discussion should be read in conjunction with our consolidated financial statements and the notes presented herein. In addition to historical information, the following Management's Discussion and Analysis of Financial Condition and Results of Operations contains forward-looking statements that involve risks and uncertainties. Our actual results could differ significantly from those anticipated in these forward-looking statements as a result of certain factors discussed herein and any other periodic reports filed and to be filed with the Securities and Exchange Commission.

Overview and Financial Condition

Discussions with respect to our Company’s operations included herein include the operations of our operating subsidiary, XRPRO Corp. Our Company formed XRPRO Corp. on July 9, 2010. We have no other operations than those of Caldera Pharmaceuticals, Inc. and XRPRO Corp.

Results of Operations for the year ended December 31, 2011 and the year ended December 31, 2010 .

Revenues

Our Company had revenues totaling $554,804 and $1,641,582 for the years ended December 31, 2011 and 2010 , respectively, a decrease of approximately 66.2%. Substantially all of our revenues to date have been from Federal government contracts. The decrease in our revenue is primarily due to the substantial completion of a number of government contracts during 2010 and the lower number of new government contracts in 2011. Due to the provisions in certain of our government contracts that include future commitments by the government to fund additional services to be provided by us, we expect that our revenues will increase in 2012. Going forward, based on financing, we plan to heavily market our XRPRO® equipment and services and educate potential customers concerning the advantages and value propositions of the XRPRO® technology. While we are optimistic about the prospects for our Company, since this is a relatively new product offering with significantly different characteristics compared with existing equipment on the market (and we have not recognized significant revenues to date), there can be no assurance about whether or when our products will generate sufficient revenues with adequate margins in order for our Company to be profitable.

Table of Contents

Cost of goods sold

Cost of goods sold totaled $342,850 and $760,728 for the years ended December 31, 2011 and 2010 , respectively. The decrease of approximately 54.9% was primarily due to the decline in revenues over the prior year . Cost of goods sold is primarily direct expenses related to providing our services under government contracts. These expenses include salary expenses directly related to research contracts, outside consultants and direct materials used on Government contracts.

Gross Profit

Gross profit was $ 211,954 and $880,854 for the years ended December 31, 2011 and 2010 , respectively. The gross margin percentages of 38.2% and 53.7% for the years ended December 31, 2011 and 2010 , respectively, relate to our Federal government contracts and may not be indicative of anticipated future results due to the Company’s plan to diversify its source of revenues into equipment sales and services.

Selling, general and administrative expenses

Selling , general and administrative expenses totaled $2,238,810 and $1,609,846 for the years ended December 31, 2011 and 2010 , respectively, an increase of 39.1 %. Payroll expenses totaled $502,302 and $337,579 in 2011 and 2010 , respectively. Stock based compensation costs, primarily related to stock options, amounted to $375,830 and $500,50 4 in 2011 and 2010 , respectively. The decrease in our stock based compensation charge was primarily due to stock issued to consultants for services performed to raise equity funding in the prior year . Legal expenses totaled $773,486 and $539,786 in 2011 and 2010 , respectively. The increase in our legal expenses was primarily due to our funding of expenses related to our suits against Los Alamos National Security LLC. (LANS) and the Regents of the University of California as well as the Bellows litigation (see Business- Legal Proceedings). While the Company has negotiated a partial contingency fee agreement in the LANS case, the Company will still face significant continuing legal expenses should it continue to pursue its actions. Our legal expenses are not connected with our regular business activities and while still ongoing should be viewed as non operating expenses. We are plaintiffs in two lawsuits and therefore to some extent we have some degree of control as to whether we will continue to fund this litigation. At present it is our judgment that the potential for recovery of damages outweighs the costs we are expending on these cases. We therefore intend to continue pursuing this litigation but there is no assurance we will continue to do so or ultimately prevail should these cases go to trial.

Depreciation and Amortization

We recognized depreciation expenses of $67,383 and $64,012 for the years ended December 31, 2011 and 2010 , respectively, which relate primarily to the depreciation of our laboratory equipment, which makes up the vast majority of our capital equipment and spending. Amortization expenses were $83,566 in each of 2011 and 2010 . Amortization expenses relates to the amortization of license fees paid to Los Alamos National Laboratories for the use of certain patents.

Interest expense

Interest expense totaled $16,376 and $20,203 for the years ended December 31, 2011 and 2010 , respectively. Interest expense was primarily paid on loans from the Los Alamos County and the revolving draw loan with Los Alamos National Bank.

Other Income

Other Income was $8,283 and $0 for the years ended December 31, 2011 and 2010 , respectively. Other income was derived primarily from refunds received from Government agencies.

Net loss

Net loss totaled ( $2,387,647 ) and ( $896,765 ), representing a net loss per share of ($ 0.50 ) and ($ .20 ) per share for the years ended December 31, 2011 and 2010 , respectively. Included in the net loss for the years ended December 31, 2011 and December 31, 2010 were stock based compensation payments of $375,830 and $500,50 4 , respectively. If such non cash payments had not been incurred our net loss for the years ended December 31, 2011 and December 31, 2010, would have been ($2,011,817) and ($396,261), respectively. In addition, legal fees of $773,486 and $539,786 were incurred in the years ended December 31, 2011 and December 31, 2010, respectively. These expenses are not operational in nature.

Table of Contents

Liquidity and Capital Resources

We have primarily financed our operations from our inception in 2003 through the sale of unregistered equity and the cash flow generated by operations. As of December 31, 2011, our Company had cash totaling $678,300 and other current assets totaling $46,121 , and total assets of $2,013,118 . We had total current liabilities of $836,743, excluding the derivative financial liability of $600,000 , and net working capital deficit of $112,322 . Total liabilities were $1,677,947 and the convertible redeemable preferred stock totaled $2,005,035 resulting in a stockholders’ deficit of ($1,669,864) at December 31, 2011.

Net cash flows consumed by operating activities totaled $1,133,606 for the year ended December 31 , 2011 . Net cash flows used in investing activities for the same period was $56,056 . Cash flows received from financing activities totaled $1,750,052 and the overall change in cash was an increase of $560,390 , of which $1,889,650 in gross proceeds was raised in a private placement which was used to repay our line of credit, repayment of a loan payable to a third party and a stockholder.

Given estimates of our Company’s future operating results and our expectations regarding the sale of our XRPRO® machines and commercial services, we believe that we have adequate financial resources to achieve cash flow break-even. We have nevertheless included a discussion concerning the presentation of our financial statements on a going concern basis in the notes to our financial statements and our independent public accountants have included a similar discussion in their opinion on our financial statements through December 31, 2011 .

Should we not achieve our forecasted operating results or should strategic opportunities present themselves such that additional financial resources would present attractive investing opportunities for our Company, we may decide in the future to issue debt or sell our Company’s equity securities in order to raise additional cash. There are no arrangements in place for any such financing at this time. We cannot provide any assurances as to whether we will be able to secure any necessary financing, or the terms of any such financing transaction if one were to occur. We currently have a $750,000 funding facility available to us from the Los Alamos National Bank. The facility expires on May 22, 2012 unless demand for repayment is made earlier and currently bears interest at a coupon of the Wall Street Journal Prime rate plus 1% with a floor of 3.25% per annum. The loan is secured by inventory, accounts receivable and other rights to payments, instruments, documents and other chattel paper, general intangibles and fixed assets. To date, we have $50,000 drawn from this facility. The loan is personally guaranteed by Benjamin Warner, our Chief Executive Officer. The loan agreement provides that we cannot incur or assume: (i) any debt other than existing debt of the date the loan agreements were executed or accounts payable incurred in the ordinary course of business or (ii) any liens other than inconsequential lines incurred in the ordinary course of business.

As of December 31 , 2011, we owed $270,952 in accordance with the terms of a Project Participation Agreement with the Incorporated County of Los Alamos that we entered into in September 2006. The loan bears interest at a rate of 5% per annum, is for a 13 year term and required no repayments for 36 months with 120 monthly repayments commencing on September 21, 2009.

Capital Expenditures

Our current plans do not call for our Company to expend significant amounts for capital expenditures for the foreseeable future beyond a potential additional XRPRO® X-ray fluorescence microscope as well as office furniture and information technology related equipment as we add employees and sales offices to our Company. Bruker produces the XRPRO products that we market and our corporate facilities are contracted for with third parties (and therefore do not require us to make capital purchases in this area).

Critical Accounting Policies

Use of estimates

The preparation of these financial statements in accordance with US GAAP requires us to make estimates and judgments that affect the reported amounts of assets, liabilities, revenues and expenses, and related disclosure of contingent assets and liabilities. We continually evaluate our estimates, including those related to bad debts, inventories, recovery of long-lived assets. We base our estimates on historical experience and on various other assumptions that we believed to be reasonable under the circumstances, the results of which form the basis for making judgments about the carrying values of assets and liabilities that are not readily apparent from other sources. Any future changes to these estimates and assumptions could cause a material change to our reported amounts of revenues, expenses, assets and liabilities. Actual results may differ from these estimates under different assumptions or conditions. We believe the following critical accounting policies affect our more significant judgments and estimates used in the preparation of the financial statements. Significant estimates include the allowance for doubtful accounts, the allowance for obsolete inventory, the useful life of property and equipment and intangible assets, and assumptions used in assessing impairment of long-term assets.

Table of Contents

Revenue recognition

Revenue sources consist of government grants, government contracts and commercial development contracts.

Government contracts and grants are received to deliver feasible research on drug candidates and the development of drug candidates and compounds to meet specific requirements as specified in the contracts and grants.

Revenues from government grants and contracts are for research and development purposes and are recognized in accordance with the terms of the award and the government agency. Grant revenue is recognized in one of two different ways depending on the grant. Cost reimbursement grants require us to submit proof of costs incurred that are invoiced by us to the government agency, which then pays the invoice. In this case, grant revenue is recognized during the period that the costs were incurred according to the terms of the government grant. Fixed cost grants require no proof of costs at the time of invoicing, but proof is required for audit purposes and grant revenue is recognized during the period that the costs were incurred according to the terms of the government grant. The grant revenue under these fixed costs grants is recognized using a percentage-of-completion method, which uses assumptions and estimates. These assumptions and estimates are developed in coordination with the principal investigator performing the work under the government fixed-cost grants to determine key milestones, expenses incurred, and deliverables to perform a percentage-of-completion analysis to ensure that revenue is appropriately recognized. Critical estimates involved in this process include total costs incurred and anticipated to be incurred during the remaining life of the grant.

Government contract revenue is recognized as allowable research and development expenses are incurred during the period and according to the terms of the government contract.

Commercial revenue is recognized when the service or development is delivered or upon complying with the relevant terms of the commercial agreement.

Intangible assets

a) License Agreements

License agreements acquired by the Company are reported at acquisition value less accumulated amortization and impairments.

b) Amortization

Amortization is reported in the income statement straight-line over the estimated useful life of the intangible assets, unless the useful life is indefinite. Amortizable intangible assets are amortized from the date that they are available for use. The estimated useful life of the license agreement is twenty years which is the term of the patent supporting the underlying license agreements

Assessment of an intangible asset’s residual value and useful life is performed annually.

Plant and equipment

Plant and equipment is stated at cost less accumulated depreciation. Depreciation is computed using straight-line method over the estimated useful lives of the assets. The estimated useful lives of the assets are as follows:

Leasehold improvements 5 Years

Laboratory equipment 7 Years

Furniture and fixtures 10 Years

Computer equipment 3 Years

The cost of repairs and maintenance is expensed as incurred; major replacements and improvements are capitalized. When assets are retired or disposed of, the cost and accumulated depreciation are removed from the accounts, and any resulting gains or losses are included in income in the year of disposition.

We examine the possibility of decreases in the value of fixed assets when events or changes in circumstances reflect the fact that their recorded value may not be recoverable. We recognize an impairment loss when the sum of expected undiscounted future cash flows is less than the carrying amount of the asset. The amount of impairment is measured as the difference between the asset’s estimated fair value and its book value.

Share-Based Compensation

Share-based compensation cost is measured at the grant date, based on the estimated fair value of the award and is recognized as expense over the employee's requisite service period on a straight-line basis. Share-based compensation expense recognized in the consolidated statements of operations and is based on awards ultimately expected to vest and has been reduced for estimated forfeitures. This estimate will be revised in subsequent periods if actual forfeitures differ from those estimates. We have no awards with market or performance conditions.

Table of Contents

Net loss per share

We calculate basic earnings per share (“EPS”) by dividing our net loss by the weighted average number of common shares outstanding for the period, without considering common stock equivalents. Diluted EPS is computed by dividing net income or net loss by the weighted average number of common shares outstanding for the period and the weighted average number of dilutive common stock equivalents, such as options and warrants. Options and warrants are only included in the calculation of diluted EPS when their effect is dilutive.

Contingencies

Certain conditions may exist as of the date the financial statements are issued, which may result in a loss to the Company but which will only be resolved when one or more future events occur or fail to occur. The Company’s management assesses such contingent liabilities, and such assessment inherently involves an exercise of judgment. In assessing loss contingencies related to legal proceedings that are pending against and by the Company or unasserted claims that may result in such proceedings, the Company’s management evaluates the perceived merits of any legal proceedings or unasserted claims as well as the perceived merits of the amount of relief sought or expected to be sought.

If the assessment of a contingency indicates that it is probable that a material loss has been incurred and the amount of the liability can be estimated, then the estimated liability would be accrued in the Company’s financial statements. If the assessment indicates that a potential material loss contingency is not probable but is reasonably possible, or is probable but cannot be estimated, then the nature of the contingent liability, together with an estimate of the range of possible loss if determinable and material would be disclosed. Loss contingencies considered to be remote by management are generally not disclosed unless they involve guarantees, in which case the guarantee would be disclosed.

Recent accounting pronouncements

For discussion of recently issued and adopted accounting pronouncements, please see Note 2 to the Caldera Pharmaceuticals financial statements included herein.

DIRECTORS, EXECUTIVE OFFICERS, PRO MO TERS AND CONTROL PERSONS

Directors and Executive Officers

The following table sets forth the name, age and position held by each of our executive officers and directors.

Name	Age	Office(s) Held
Dr. Benjamin Warner	43	President, Chief Executive Officer, Treasurer, Director
Edward Roffman	62	Director
Jeremiel Zimmerman	62	Director

Dr. Benjamin Warner - President, Chief Executive Officer, Treasurer and Director

Since its incorporation in 2003, Dr. Warner has served as our President, Chief Executive Officer, Treasurer and a director. Before founding the Company, Dr. Warner worked in technology development, patenting, and marketing at the Los Alamos National Laboratory and in the development of “dual use” government / commercial technologies. Dr. Warner has co-developed technologies that have led to the formation of several technology companies. Dr. Warner holds a Ph.D. in Chemistry from MIT and a BS from the University of the South. Dr. Warner is the co-inventor on 30+ patents/pending patents. After MIT, Dr. Warner joined Los Alamos National Laboratory where he held the position of Project Leader for National Security Programs from 2000 until 2004.

Dr. Warner has been associated with the Company since its inception and brings to the board extensive knowledge about our business operations and in particular our licenses and products. Having developed our technology Dr. Warner brings to the board significant strategic, business and financial experience related to the business and financial issues facing pharmaceutical companies and particularly our company. Dr. Warner has a broad understanding of the operational, financial and strategic issues facing pharmaceutical companies.

Table of Contents

Ed Roffman, Director

Mr. Roffman has been a director since December 2011. Since April 2006, Mr. Roffman has consulted with various early stage high technology companies. During this time, consulting projects have included the part-time Chief Financial Officer of Alphabird, Inc. (since January 2011) (Alphabird is in the online video advertising business), the part-time Chief Financial Officer of Public Media Works, Inc. (October 2010 to October 2011) (Public Media Works was in the video rental business) and from January 2008 to December 2009, Mr. Roffman was the part-time Chief Financial Officer of Cryptic Studios, a developer of massively multiplayer video games. Mr. Roffman served as Chief Financial Officer of Red Mile Entertainment, Inc. from January 2005 until April 2006 and at Fluent Entertainment, Inc. from February 2003 to December 2004. Both companies are consumer software developers and publishers. Mr. Roffman has also been a principal of Creekside, LLC, a consulting firm which specializes in the software, internet and consumer products industries. From August 1995 to January 1999, Mr. Roffman served as Chief Financial Officer and Chief Operating Officer at Palladium Interactive, Inc., a consumer software company. Mr. Roffman served on the board and audit committee of Silverstar Holdings (NASDAQ: SSTR) a publisher and developer of interactive entertainment software and Adex Media (NASDAQ: ADXM) an Internet marketing and lead generation publisher and developer, manufacturer, and marketer of consumer products and Westinghouse Solar, Inc., (formerly Akeena Solar), a designer and distributor of solar modules (NASDAQ). Mr. Roffman is a CPA with over 30 years of experience in accounting and finance. Mr. Roffman earned a BBA in accounting from Temple University.

Mr. Roffman’s achievements in financial and accounting matters, his overall business understanding, as well as his familiarity and knowledge regarding public companies and corporate governance issues that public companies face make him an ideal board candidate.

Jeremiel Zimmerman – Director

Mr. Zimmerman co-founded Caldera and has been a director since August 2005. Mr. Zimmerman has been a commodity trading advisor and a drafter of newsletter regarding commodities and other securities since 1991. He currently prepares for AMMO Trading Group a news letter with a daily analysis of the e-Mini S&P in addition to hosting an Internet discussion group regarding commodity futures trading. He is registered as a Series 3 broker with the NFA

Mr. Zimmerman’s understanding of the financial markets as well as his overall business understanding make him an attractive board member.

Two of our directors, Dr. Benjamin Warner and Jeremiel Zimmerman, are first cousins, once removed.

Term of Office

Our directors hold office until the next annual general meeting of our shareholders or until removed from office in accordance with our bylaws. Our officers are appointed by our board of directors and hold office until removed by the board.

EXECUTIVE COMPENSA TION AND OTHER INFORMATION

Executive Compensation

The following table sets forth all compensation awarded, earned or paid for services rendered to our principal executive officer, principal financial officer and each executive officer whose compensation exceeded $100,000 during each of the fiscal years ended December 31, 2011 and 2010.

Summary Compensation Table

Name and Principal Position	Year		Salary ($)		Bonus ($)		Option Awards ($)		Non-Equity Incentive Plan Compensation ($)		Nonqualified Deferred Compensation Earnings ($)		All Other Compensation ($) (1)(2)		Total ($)
Dr. Benjamin Warner, President and Chief Executive Officer, Treasurer		2011 2010		199,700 193,442		-		-		-		-		24,196 28,917		223,896 222,359

Lori Peterson Chief Operating Officer*		2011 2010		144,000 119,641		-		-		-		-		12,319 7,933		155 ,319 127, 574

*Lori Peterson resigned as Chief Operating Officer in November 2011.

(1) All Other Compensation for the year ended December 31, 2011 for Dr. Benjamin Warner includes $14,502.43 for health care, $5,991 for contributions to his 401(K) plan, and $3,703 for cell phone reimbursement. All Other Compensation for the year ended December 31, 2010 for Dr. Benjamin Warner includes $19,108.24 for health care, $5,803.19 for contributions to his 401(K) plan, and $4,006 for cell phone reimbursement.

(2) All Other Compensation for the year ended December 31, 2011 for Lori Peterson includes $8,110.48 for health care, $3,84956 for contributions to her 401(K) plan and $360 for cell phone reimbursement. All Other Compensation for the year ended December 31, 2010 for Lori Peterson includes $4,361.88 for health care and $3,571for contributions to her 401(K) plan.

Table of Contents

Employment Agreements

On October 25, 2006, we entered into an Employment Agreement with Dr. Benjamin Warner pursuant to which Dr. Warner was appointed our Chief Executive Officer to serve in such role until the agreement is terminated. For such services, the agreement provides that Dr. Warner is to be paid a base salary of $200,000 in addition to certain bonuses and benefits. If Dr. Warner is terminated for cause (as defined in the agreement), he is only entitled to accrued amounts owed to him; however if he is terminated without cause he is entitled to three months base salary and accrued benefits. For the years ended December 31, 2010 and December 31, 2011, Dr. Warner agreed to a salary reduction in order to comply with certain limitations imposed in certain grants we received.

From 2009 through 2011, Lori Peterson served as our Chief Operating Officer. She currently serves as our Program Manager/ Molecular Epidemiologist. On August 17, 2006, we entered into an Employment Agreement with Lori Peterson to serve as our Program Manager/ Molecular Epidemiologist until the agreement is terminated. For such services, the agreement provides that Ms. Peterson is to be paid a base salary of $100,000 in addition to certain bonuses and benefits. Ms. Paterson has since received several raises to bring her salary to $144,000.

Outstanding Equity Awards at Fiscal Year End

The table below summarizes all unexercised options, stock that has not vested, and equity incentive plan awards for each named executive officer as of December 31, 2011.

OUTSTANDING EQUITY AWARDS AT FISCAL YEAR-END
	OPTION AWARDS											STOCK AWARDS
Name	Number of Securities Underlying Unexercised Options (#) Exercisable		Number of Securities Underlying Unexercised Options (#) Unexercisable		Equity Incentive Plan Awards: Number of Securities Underlying Unexercised Unearned Options (#)		Option Exercise Price ($)			Option Expiration Date		Number of Shares or Units of Stock That Have Not Vested (#)		Market Value of Shares or Units of Stock That Have Not Vested ($)		Equity Incentive Plan Awards: Number of Unearned Shares, Units or Other Rights That Have Not Vested (#)		Equity Incentive Plan Awards: Market or Payout Value of Unearned Shares, Units or Other Rights That Have Not Vested (#)
Dr. Benjamin Warner		-		-		-		-			-		-		-		-	-

Lori Peterson		50,000		-		-		5.71			8/16		-		-		-	-
		220,000						1.10	2		2/21

Table of Contents

Director Compensation

The table below summarizes all compensation of our directors for the year ended December 31, 2011.

DIRECTOR COMPENSATION*
Name	Fees Earned or Paid in Cash ($)		Stock Awards ($)		Option Awards ($)		Non-Equity Incentive Plan Compensation ($)		Non-Qualified Deferred Compensation Earnings ($)		All Other Compensation ($)	Total ($)
Dr. Benjamin Warner		0		0		0		0		0	0		0

Lori Peterson**		0		0		0		0		0	0		0

Jeremiel Zimmerman		0		0		0		0		0	0		0

* Does not include compensation received for services provided as executive officers

**Lori Peterson resigned from the Board of Directors on November 15, 2011, effective upon the election of an outside director to replace her.

Corporate Governance

Leadership Structure

Our Chief Executive Officer Dr. Benjamin Warner also serves as Chairman of the Board. Our Board of Directors does not have a lead independent director. Our Board of Directors has determined that its leadership structure was appropriate and effective for the Company given its stage of operations.

Board Committees

We presently do not have an audit committee, compensation committee or nominating committee or committee performing similar functions, as our management believes that until this point it has been premature at the early stage of our management and business development to form an audit, compensation or nominating committee.

Director Independence

The Board has determined that Messrs. Zimmerman and Rothman are “independent” in accordance with the requirements of Rule 10A-3 under the Exchange Act.

SECURITY OWNERSHIP OF CERTAIN B ENE FICIAL OWNERS AND MANAGEMENT

The following table sets forth, as of April 15 , 2012, information with respect to the securities holdings of: (i) our officers and directors; and (ii) all persons (currently none) which, pursuant to filings with the SEC and our stock transfer records, we have reason to believe may be deemed the beneficial owner of more than five percent (5%) of our common stock. The securities "beneficially owned" by an individual are determined in accordance with the definition of "beneficial ownership" set forth in the regulations promulgated under the Exchange Act and, accordingly, may include securities owned by or for, among others, the spouse and/or minor children of an individual and any other relative who resides in the same home as such individual, as well as other securities as to which the individual has or shares voting or investment power or which each person has the right to acquire within 60 days through the exercise of options or otherwise. Beneficial ownership may be disclaimed as to certain of the securities. This table has been prepared based on the number of shares outstanding totaling 4, 302,270 , adjusted individually as shown below.

Table of Contents

Name and Address of Beneficial Owner	Amount and Nature of Beneficial Ownership		Percentage of Class Beneficially Owned (1)

Ed Roffman		20,000		*

Dr. Benjamin Warner ( 2)		3,238,015		7 5 .5	%

Jeremiel Zimmerman		104,000		2.4	%

All directors and executive officers as a group (3 persons)		3, 36 2,015		7 8.40	%

* Less than 1%

(1)	Percentage of class beneficially owned is calculated by dividing the amount and nature of beneficial ownership by the total shares of common stock outstanding plus the shares subject to warrants and options that are currently exercisable or exercisable within 60 days of February 1, 2012.

(2)

Includes 25,035 shares of Series A preferred stock which is convertible into 25,035 shares of common stock. Includes 1,445 shares of common stock issued as a dividend with respect to his shares of Series A preferred stock . Also includes warrants to purchase 25,035 shares of common stock. The Series A preferred stock and the warrants are held by jointly by Dr. Warner and his wife, Ellen McBee.

(3)	Unless otherwise set forth herein, the address of each beneficial owner is 278 DP Road, Suite D, Los Alamos, New Mexico 87587544

SELLING ST OC KHOLDERS

The shares to be offered by the selling security holders were issued in private placement transactions by us, each of which was exempt from the registration requirements of the Securities Act. The shares offered hereby are “restricted” securities under applicable federal and state securities laws and are being registered under the Securities Act, to give the selling security holders the opportunity to publicly sell these shares. This prospectus is part of a registration statement on Form S-1 filed by us with the Securities and Exchange Commission under the Securities Act covering the resale of such shares of our common stock from time to time by the selling security holders. No estimate can be given as to the amount or percentage of our common stock that will be held by the selling security holders after any sales made pursuant to this prospectus because the selling security holders are not required to sell any of the shares being registered under this prospectus. The following table assumes that the selling security holders will sell all of the shares listed in this prospectus.

The following table sets forth the name of each person who is offering for resale shares of common stock covered by this prospectus, the beneficial ownership of each selling security holder, the number of shares of common stock that may be sold in this offering and the number of shares of common stock each will own after the offering, assuming they sell all of the shares offered. The term “selling security holder” or “selling security holders” includes the stockholders listed below and their respective successors. Beneficial ownership is determined in accordance with the rules of the Securities and Exchange Commission and generally includes voting or investment power with respect to securities.

Table of Contents

Shareholder and Name of Person Controlling	Number of Shares Before Offering			Number of Shares Offered		Date Acquired			Amount of Shares Owned After Offering		Percent of Shares Held After Offering

Eight Family Trust		27,851	(1)		27,851	3/22/2011				0		0
Chang-Tai Hsieh		19,756	(2)		19,756	3/24/2011				0		0
Joseph Amato Revocable Trust		52,632	(3)		52,632	4/7/2011				0		0
Sin Fa Wang and Mei Wang		18,058	(4)		18,058	4/11/2011				0		0
S/L Trilling Trust		36,104	(5)		36,104	4/14/2011				0		0
Douglas Jensen		27,785	(6)		27,785	4/18/2011				0		0
Mark Litwin		35,088	(7)		35,088	4/26/2011				0		0
Robert S. Colman		18,027	(8)		18,027	4/27/2011				0		0
2030 Investors LLC/401K Plan		51,293	(9)		51,293	5/12/2011				0		0
Sarah Abrams		42,998	(10)		42,998	5/12/2011				0		0
Matthew Abrams		92,998	(11)		92,998	5/12/2011				0		0
Joseph W. and Patricia G. Family Trust		160,450	(12)		160,450	5/16/2011				0		0
James Jensen		70,000	(13)		70,000	6/7/2011				0		0
Chan Kei Blu		53,301	(14)		53,301	9/8/2011				0		0
Louitt & V. Hannan, Inc. Salary Deferral Plan FBO J. Thomas Hannan		17,757	(15)		17,757	9/13/2011				0		0
George Mainas		17,699	(16)		17,699	10/13/2011				0		0
Saunders and Diane Kohn		70,588	(17)		70,588	10/17/2011				0		0
David Steinhardt and Tobi B Richman Steinhardt Trust		20,176	(18)		20,176	1/22/2012				0		0
Los Alamos National Security, LLC		157,500	(19)		157,500		(19	)		0		0
Richard Scott Lane		73,571	(20)		73,571		(20	)		0		0
Aldermon Holdings		17,500	(21)		17,500		(21	)		0		0
TRV, LLC		8,750	(22)		8,750	4/6/2006				0		0
David Clark		8,750			8,750	5/9/2006				0		0
CO 51 AIC Holdings LLC		87,565	(23)		87,565	9/22/2006				0		0
Jack Warner		10,000			10,000	10/10/2006				0		0
Cirrus Advisors, Inc.		26,250	(24)		26,250		(24	)		0		0
Michael Lyon Profit Sharing Plan		25,715	(24)		25,715		(24	)		0		0
Susan Gerard		26,250	(24)		26,250		(24	)		0		0
Susan Gerard IRA		25,714	(24)		25,714		(24	)		0		0
Nathan H. Zahler		2,418	(25)		2,418		(25	)		0		0
Gregg Rzepczynski		2,459	(26)		2,459		(26	)		0		0
Emelia A. Solomon		1,830	(27)		1,830		(27	)		0		0
Pratima Bharti		636	(28)		636		(28	)		0		0
First South Africa Management		100,000	(29)		100,000		(29	)		0		0
Total		1, 407,469			1, 407,469					0		0

(1)

Includes 13,500 shares of common stock which are convertible upon conversion of the Series A Preferred Stock, 13,500 shares of common stock which are issuable upon exercise of the warrant and 851 shares of common stock that were issued in February 14, 2012 as a dividend with respect to the Series A preferred stock. Walter Bilofsky has sole voting and dispositive power with respect to these securities.

(2)

Includes (i) 8,772 shares of common stock which are convertible upon conversion of the Series A Preferred Stock; (ii) 8,772 shares of common stock which are issuable upon exercise of the warrant; (iii) 324 shares of common stock issued upon exercise stock options that were exercised on March 3, 2011; (iv) 420 shares of common stock issued upon exercise stock options that were exercised on March 17, 2011; (v) 420 shares of common stock issued upon exercise stock options that were exercised on March 31, 2011; (vi) 419 shares of common stock issued upon exercise stock options that were exercised on April 14, 2011; (vii) 420 shares of common stock issued upon exercise stock options that were exercised on April 28, 2011; and (viii) 209 stock options that were exercised on May 26, 2011.

(3)	Includes 26,316 shares of common stock which are convertible upon conversion of the Series A Preferred Stock and 26,316 shares of common stock which are issuable upon exercise of the warrant . Joseph Amato has sole voting and dispositive power with respect to these securities.

(4)

Includes 8,772 shares of common stock which are convertible upon conversion of the Series A Preferred Stock, 8,772 shares of common stock which are issuable upon exercise of the warrant and 514 shares of common stock that were issued in February 14, 2012 as a dividend with respect to the Series A preferred stock.

(5)

Includes 17,544 shares of common stock which are convertible upon conversion of the Series A Preferred Stock, 17,544 shares of common stock which are issuable upon exercise of the warrant and 1,016 shares of common stock that were issued in February 14, 2012 as a dividend with respect to the Series A preferred stock. Stan Trilling has sole voting and dispositive power with respect to these securities.

(6)

Includes (i) 5,000 shares of common stock which are convertible upon conversion of the Series A Preferred Stock; (ii) 5,000 shares of common stock which are issuable upon exercise of the warrant; (iii) 10,500 shares of common stock that were issued on February 6, 2006; and (iv) 7,000 shares of common stock that were issued on July 19, 2006 and 285 shares of common stock that were issued in February 14, 2012 as a dividend with respect to the Series A preferred stock.

(7)	Includes 17,544 shares of common stock which are convertible upon conversion of the Series A Preferred Stock and 17,544 shares of common stock which are issuable upon exercise of the warrant

(8)

Includes 8,772 shares of common stock which are convertible upon conversion of the Series A Preferred Stock, 8,772 shares of common stock which are issuable upon exercise of the warrant and 483 shares of common stock that were issued in February 14, 2012 as a dividend with respect to the Series A preferred stock.

(9)

Includes 25,000 shares of common stock which are convertible upon conversion of the Series A Preferred Stock, 25,000 shares of common stock which are issuable upon exercise of the warrant and 1,293 shares of common stock that were issued in February 14, 2012 as a dividend with respect to the Series A preferred stock. Ellison Morgan has sole voting and dispositive power with respect to these securities.

Table of Contents

(10)

Includes: (i) 8,772 shares of common stock which are convertible upon conversion of the Series A Preferred Stock; (ii) 8,772 shares of common stock which are issuable upon exercise of the warrant; and (iii) 25,000 shares of common stock that were issued on October 26, 2010 for services rendered and 454 shares of common stock that were issued in February 14, 2012 as a dividend with respect to the Series A preferred stock.

(11)

Includes (i) 8,772 shares of common stock which are convertible upon conversion of the Series A Preferred Stock; (ii) 8,772 shares of common stock which are issuable upon exercise of the warrant; (iii) 75,000 shares of common stock that were issued on October 26, 2010 for services rendered and 454 shares of common stock that were issued in February 14, 2012 as a dividend with respect to the Series A preferred stock.

(12)

Includes (i) 43,860 shares of common stock which are convertible upon conversion of the Series A Preferred Stock; (ii) 43,860 shares of common stock which are issuable upon exercise of the warrant; and (ii) 70,500 shares of common stock that were issued on October 26, 2010 for services rendered and 2,230 shares of common stock that were issued in February 14, 2012 as a dividend with respect to the Series A preferred stock. Joseph Abrams has sole voting and dispositive power with respect to these securities.

(13)	Includes (i) 35,000 shares of common stock which are convertible upon conversion of the Series A Preferred Stock; (ii) 35,000 shares of common stock which are issuable upon exercise of the warrant.

(14)

Includes 26,316 shares of common stock which are convertible upon conversion of the Series A Preferred Stock, 26,316 shares of common stock which are issuable upon exercise of the warrant and 669 shares of common stock that were issued in February 14, 2012 as a dividend with respect to the Series A preferred stock.

(15)

Includes 8,772 shares of common stock which are convertible upon conversion of the Series A Preferred Stock, 8,772 shares of common stock which are issuable upon exercise of the warrant and 213 shares of common stock that were issued in February 14, 2012 as a dividend with respect to the Series A preferred stock. Thomas Hannan has sole voting and dispositive power with respect to these securities.

(16)

Includes 8,772 shares of common stock which are convertible upon conversion of the Series A Preferred Stock, 8,772 shares of common stock which are issuable upon exercise of the warrant and 155 shares of common stock that were issued in February 14, 2012 as a dividend with respect to the Series A preferred stock.

(17)

Includes 35,000 shares of common stock which are convertible upon conversion of the Series A Preferred Stock,35,000 shares of common stock which are issuable upon exercise of the warrant and 588 shares of common stock that were issued in February 14, 2012 as a dividend with respect to the Series A preferred stock.

(18)

Includes 10,088 shares of common stock which are convertible upon conversion of the Series A Preferred Stock and 10,088 shares of common stock which are issuable upon exercise of the warrant. David Steinhardt and Tobi B Richman Steinhardt have shared voting and dispositive power with respect to these securities.

(19)	Shares issued on June 15, 2006 in connection with a license agreement. Charles McMillan has sole voting and dispositive power with respect to these securities.

(20)	Includes (i) 35,000 shares of common stock that were issued on January 23, 2006; and (ii) 38,571 shares of common stock that were issued on October 22, 2010 in connection with a settlement agreement.

(21)	Includes (i) 8,750 shares of common stock that were issued on March 27, 2006; and (ii) 8,750 shares of common stock that were issued on May 19, 2006. Yves Malki has sole voting and dispositive power with respect to these securities.

(22)	Robert Gurolnick has sole voting and dispositive power with respect to these securities.

(23)	Paul Daguerdas has sole voting and dispositive power with respect to these securities.

(24)

Includes (i) 52,500 shares of common stock that were issued on August 1, 2006 for services rendered of which 26,250 shares were transferred to Cirrus Advisors, Inc. a company which Mr. Lyons has a controlling interest and 26,250 were transferred on August 3, 2011 to Susan Gerard as part of a divorce settlement; and (ii) 51,429 shares of common stock that were issued on October 22, 2010 of which 25,715 shares were transferred to the Michael T. Lyon Profit Sharing Plan and 25,714 shares were transferred on August 3, 2011 to the Susan Gerard IRA as part of a divorce settlement between Lyon and Gerard. Michael Lyon has sole voting and dispositive power with respect to the securities held by each of Cirrus Advisors, Inc. and the Michal T. Lyon Profit Sharing Plan. Susan Gerard has sole voting and dispositive power with respect to the securities held by the Susan Gerard IRA.

(25)

Includes (i) 381 shares of common stock issued upon exercise stock options that were exercised on March 3, 2011; (ii) 453 shares of common stock issued upon exercise stock options that were exercised on March 17, 2011; (iii) 453 shares of common stock issued upon exercise stock options that were exercised on March 31, 2011; (iv) 452 shares of common stock issued upon exercise stock options that were exercised on April 14, 2011; (v) 453 shares of common stock issued upon exercise stock options that were exercised on April 28, 2011; and (vi) 226 shares of common stock issued upon exercise stock options that were exercised on May 26, 2011.

(26)

Includes (i) 326 shares of common stock issued upon exercise stock options that were exercised on March 3, 2011; (ii) 474 shares of common stock issued upon exercise stock options that were exercised on March 17, 2011; (iii) 474 shares of common stock issued upon exercise stock options that were exercised on March 31, 2011; (iv) 474 shares of common stock issued upon exercise stock options that were exercised on April 14, 2011; (v) 474 shares of common stock issued upon exercise stock options that were exercised on April 28, 2011; and (vi) 237 shares of common stock issued upon exercise stock options that were exercised on May 26, 2011.

(27)

Includes (i) 333 shares of common stock issued upon exercise stock options that were exercised on March 3, 2011; (ii) 333 shares of common stock issued upon exercise stock options that were exercised on March 17, 2011; (iii) 333 shares of common stock issued upon exercise stock options that were exercised on March 31, 2011; (iv) 332 shares of common stock issued upon exercise stock options that were exercised on April 14, 2011; (v) 333 shares of common stock issued upon exercise stock options that were exercised on April 28, 2011; and (vi) 166 shares of common stock issued upon exercise stock options that were exercised on May 26, 2011.

(28)

Includes (i) 178 shares of common stock issued upon exercise stock options that were exercised on March 17, 2011; (ii) 154 shares of common stock issued upon exercise stock options that were exercised on March 31, 2011; (iii) 165 shares of common stock issued upon exercise stock options that were exercised on April 14, 2011; and (iv) 139 shares of common stock issued upon exercise stock options that were exercised on April 28, 2011.

(29)	Shares issued on December 2011 and February 2012 for services rendered. Clive Kabatznik has sole voting and dispositive power with respect to these securities.

Table of Contents

PLAN OF DIS TR IB UTION

Each selling security holder of our common stock and any of their transferees, pledgees, assignees, donees, and successors-in-interest may, from time to time, sell any or all of their shares of common stock on the stock exchange on which they are listed on the OTC Bulletin Board, if quoted on the OTC Bulletin Board, or in private transactions. These sales will be at a fixed price of $5.00 per share until the shares of common stock are listed on the OTC Bulletin Board, after which sales may be at prevailing market prices or privately negotiated prices. Selling security holders may use any one or more of the following methods when selling shares:

•	ordinary brokerage transactions and transactions in which the broker-dealer solicits purchasers;

•	block trades in which the broker-dealer will attempt to sell the shares as agent but may position and resell a portion of the block as principal to facilitate the transaction;

•	purchases by a broker-dealer as principal and resale by the broker-dealer for its account;

•	an exchange distribution in accordance with the rules of the applicable exchange;

•	privately negotiated transactions;

•	broker-dealers may agree with the selling security holders to sell a specified number of such shares at a stipulated price per share;

•	a combination of any such methods of sale; or

•	any other method permitted pursuant to applicable law.

The selling security holders may also sell shares under Rule 144 under the Securities Act, if available, rather than under this prospectus.

Broker-dealers engaged by the selling security holders may arrange for other brokers-dealers to participate in sales. Broker-dealers may receive commissions or discounts from the selling security holders (or, if any broker-dealer acts as agent for the purchaser of shares, from the purchaser) in amounts to be negotiated. Each selling security holder does not expect these commissions and discounts relating to its sales of shares to exceed what is customary in the types of transactions involved.

The selling security holders and any broker-dealers or agents that are involved in selling the shares of common stock may be deemed to be “underwriters” within the meaning of the Securities Act in connection with such sales. In such event, any commissions received by such broker-dealers or agents and any profit on the resale of the shares purchased by them may be deemed to be underwriting commissions or discounts under the Securities Act. Because selling security holders may be deemed to be underwriters within the meaning of the Securities Act, they will be subject to the prospectus delivery requirements of the Securities Act. Discounts, concessions, commissions and similar selling expenses, if any, that can be attributed to the sale of common stock will be paid by the selling security holders and/or the purchasers. Each selling security holder has represented and warranted to us that it acquired the securities subject to this registration statement in the ordinary course of such selling security holder’s business and, at the time of its purchase of such securities such selling security holder had no agreements or understandings, directly or indirectly, with any person to distribute any such securities.

There is no underwriter or coordinating broker acting in connection with the proposed sale of the resale shares by the selling security holders. We are required to pay certain fees and expenses incurred by us incident to the registration of the shares. We have agreed to indemnify the selling security holders against certain losses, claims, damages and liabilities, including liabilities under the Securities Act.

The selling securityholders may from time to time pledge or grant a security interest in some or all of the shares owned by them and, if they default in the performance of their secured obligations, the pledgees or secured parties may offer and sell shares of common stock from time to time under this prospectus, or under an amendment to this prospectus under Rule 424(b)(3) or other applicable provision of the Securities Act amending the list of selling securityholders to include the pledgee, transferee or other successors-in-interest as selling security holders under this prospectus. Upon our company being notified in writing by a selling security holder that any material arrangement has been entered into with a broker-dealer for the sale of common stock through a block trade, special offering, exchange distribution or secondary distribution or a purchase by a broker or dealer, a supplement to this prospectus will be filed, if required, pursuant to Rule 424(b) under the Securities Act, disclosing (i) the name of each such selling securityholder and of the participating broker-dealer(s), (ii) the number of shares involved, (iii) the price at which such the shares of common stock were sold, (iv) the commissions paid or discounts or concessions allowed to such broker-dealer(s), where applicable, (v) that such broker-dealer(s) did not conduct any investigation to verify the information set out or incorporated by reference in this prospectus, and (vi) other facts material to the transaction. In addition, upon our company being notified in writing by a selling securityholder that a donee or pledgee intends to sell more than 500 shares of common stock, a supplement to this prospectus will be filed if then required in accordance with applicable securities law.

Table of Contents

Under applicable rules and regulations under the Exchange Act, any person engaged in the distribution of the resale shares may not simultaneously engage in market making activities with respect to our common stock for a period of two business days prior to the commencement of the distribution. In addition, the selling security holders will be subject to applicable provisions of the Exchange Act and the rules and regulations thereunder, including Regulation M, which may limit the timing of purchases and sales of shares of our common stock by the selling security holders or any other person. We will make copies of this prospectus available to the selling securityholders and have informed them of the need to deliver a copy of this prospectus to each purchaser at or prior to the time of the sale.

CERTAIN RELATIONSHIPS AND RELATED TRANSACTIONS

Our Chief Executive Officer is a guarantor on our revolving loan from Los Alamos National Bank, pursuant to which there is currently $50,000 outstanding.

During the year ended December 31, 2010 we had an outstanding loan from our Chief Executive Officer of $77,600. At April 30, 2011 the loan amount was $1 42,700 . The loan was not evidenced by a written instrument, did not accrued interest and had no fixed repayment terms. In April 2011, the amounts owed under the loan were exchanged for 25,035 additional shares of our Series A Preferred Stock and a warrant exercisable for 25,035 shares of our common stock.

DESCRIPTION OF SECURITIES

General

Following the consummation of the Offering, assuming that the Offering is fully subscribed, the Company will have 4, 302,270 shares of common stock outstanding. The Company currently has outstanding 4, 302,270 shares of Common Stock, 341,607 shares of Series A preferred stock outstanding, warrants exercisable for 399,40 7 shares of common stock and options exercisable for 518,445 shares of common stock.

Preferred Stock

The Company is authorized to issue 10,000,000 shares of preferred stock, of which 400,000 shares have been designated as Series A preferred stock and currently has 341,607 Shares of Series A preferred stock outstanding.

The Series A preferred stock has the following designations, preferences, and rights.

Dividend Rights. Holders of Shares of Series A preferred stock are entitled to receive a dividend of $0.46 for each share of Series A preferred stock on January 1 of each year (subject to pro-rations for any short year) payable in (i) cash; or (ii) fully paid and non-assessable shares of Common Stock of the Company at a price of $5.70 per Common Share, at the option of the holder. Holders shall be entitled to additional dividends only when, as and if declared by the Board of Directors of the Company. On February 14, 2012, we issued 10,650 shares of common stock to our holders of shares of Series A preferred stock as payment of the dividend that was owed to them as of January 1, 2012 .

Voting Rights. On any matter presented to the common stockholders of the Company for their action or consideration at any meeting of stockholders of the Company (or by written consent of the stockholders in lieu of a meeting), each holder of outstanding Shares of Series A preferred stock is entitled to cast one vote for each share of Series A preferred stock held by such holder as of the record date for determining Stockholders entitled to vote on such matter. Except as provided by law, holders of Series A preferred stock shall vote together with holders of the Common Stock of the Company as a single class.

Liquidation Rights. In the event of any termination, liquidation, dissolution or winding up of the Company either voluntary or involuntary (a “Liquidation Event”), the holders of Shares of Series A preferred stock are entitled to be paid out of the assets of the Company available for distribution to its stockholders before any payment shall be made to the holders of Common Stock by reason of their ownership thereof, an amount per share equal to the greater of: (i) $5.70 per share, plus any dividends declared but unpaid thereon, or (ii) such amount per share as would have been payable had all shares of Series A preferred stock been converted into Common Stock immediately prior to such Liquidation Event. If upon any such Liquidation Event the assets of the Company available for distribution to its stockholders shall be insufficient to pay the holders of shares of Series A preferred stock the full amount to which they shall be entitled under their liquidation rights, the holders of shares of Series A preferred stock shall share ratably in any distribution of the assets available for distribution in proportion to the respective amounts which would otherwise be payable in respect of the shares held by them upon such distribution if all amounts payable on or with respect to such shares were paid in full.

Conversion Rights

Voluntary Conversion . Holders of Series A preferred stock may, at its election, convert each share of Series A preferred stock into that number of fully paid and non-assessable shares of Common Stock (or such other equity security of the Company for which all of its Common Stock has been exchanged or into which all of its Common Stock has been converted) equal to $5.70 per share.

A utomatic (Mandatory) Conversion . Ten (10) trading days after delivery to the holders of written notice of conversion by the Company, each share of Series A preferred stock then outstanding shall, by virtue of such conditions and without any action on the part of a holder thereof, be deemed automatically converted into one (1) fully paid and non-assessable share of Common Stock (or such other equity security of the Company for which all of its Common Stock has been exchanged or into which all of its Common Stock has been converted), provided that the volume weighted average closing price of the Company’s Common Stock over the ten (10) trading days immediately preceding the date of the Company’s Notice is at least $10.00 per share.

Table of Contents

Redemption Rights

Voluntary Redemption . At any time after the date that the Company receives net cash proceeds of at least three million ($3,000,000) from litigation proceedings against the Managers of Los Alamos National Laboratory, a holder of Series A preferred stock may, at its election, redeem each share of Series A preferred stock at a price of $7.41 for each share of Series A preferred stock.

Involuntary Redemption . Thirty (30) days after delivery to the holders of written notice of redemption by the Company (the “Company’s Redemption Notice”) each share of Series A preferred stock then outstanding shall, by virtue of such conditions and without any action on the part of a holder thereof, be redeemed at a price of $7.41 for each share of Series A preferred stock.

Registration Rights . Not less than twenty one (21) days before Company files a Registration Statement (the “Company’s Registration Notice”), whether or not for sale for Company’s own account, on a form and in a manner that would permit registration of registrable securities, the Company shall deliver to holder written notice of intent to file such Registration Statement. Holder may, at its election, elect to include the underlying shares of Common Stock from such holder’s shares of Series A preferred stock in such Registration Statement.

Common Stock

We are authorized to issue 50,000,000 shares of common stock, of which 4, 302,270 are issued and outstanding.

Dividend Rights . The holders of the Common Stock are entitled to receive such dividends as may be declared from time to time by the Company’s Board of Directors out of funds legally available therefore. The sole source of funds available for the payment of dividends will be from any excess funds of the Company. The Company does not believe that there will be excess funds for the foreseeable future.

Voting Rights . The holders of the Common Stock are entitled to one vote per share on all matters to be voted upon by the Company’s stockholders and do not have cumulative voting rights in the election of directors.

Redemption and No Pre-emptive Rights . The Common Stock is not subject to redemption and stockholders of the Company do not have pre-emptive rights.

Liquidation Rights . Upon any Liquidation Event, after the payment of all debts and preferential amounts required to be paid to the holders of Shares of Series A preferred stock, the remaining assets of the Company available for distribution to its stockholders shall be distributed among the holders of shares of Common Stock, pro rata based on the number of shares held by each such holder.

Warrants

As of the date hereof there are warrants exercisable for 399,407 shares of common stock outstanding. Of such warrants, warrants exercisable for: (i) 316,572 shares of common stock were issued to investors in private placements in connection with the issuance of our Series A preferred stock; (ii) 42,800 shares of common stock were issued as fees in connection with the private placement; (iii) 15,000 shares of common stock were issued as fees for services and (iv) 25,035 shares of common stock were issued to Benjamin Warner in partial exchange for amounts owed to him. The warrants, except for the 15,000 warrants issued as fees for services, which are exercisable at $2.00 per share, are exercisable at a price of $5.70 per share for a period of five years from issuance.

Options

As of the date hereof, there are options exercisable for 518,445 shares of our common stock issued under the 2005 Stock Option Plan. All of the options were issued in consideration with the performance of services. All of the options have a ten year life with the exception of one option exercisable for 250 shares of common stock issued in August 2008 that has a 4 year life and three options issued in 2011 that have a two year life. All of the options are exercisable at a price of $5.71 per share with the exception of two options granted in 2005 which are exercisable for an aggregate of $30,000 shares of common stock at an exercise price of $2.00 per share and one option issued in February 2011 exercisable for 220,000 shares of common stock of at an exercise price of $1.10 per share. Options exercisable for 478,570 shares of common stock are vested, and the remaining options fully vest at various times throughout 2012 and 2013. In accordance with the terms of the 2005 Stock Option Plan options granted to employees that are not vested at the time of termination of employment shall terminate upon such termination and all options vested at the time of termination are exercisable for an additional one year from the date of termination unless otherwise extended by the Board of Directors.

Transfer Agent and Registrar

Our transfer agent and registrar is Corporate Stock Transfer, Inc., 3200 Cherry Creek Drive South, Suite 430, Denver, Colorado 80209.

Table of Contents

EXP ERT S

The consolidated financial statements of Caldera Pharmaceuticals, Inc. as of December 31, 201 1 and 20 10 included in this Preliminary Prospectus and in the Registration Statement have been so included in reliance on the reports of Sherb & Co., an independent registered public accounting firm, appearing elsewhere herein and in the Registration Statement, given on the authority of said firm as experts in auditing and accounting.

DISCLOSURE OF COMMISSION POSI TION OF INDEMNIFICATION FOR SECURITIES ACT LIABILITIES

Pursuant to our Second Amended and Restated Articles of Incorporation, our Board of Directors may issue additional shares of common or preferred stock. Any additional issuance of common stock or the issuance of preferred stock could have the effect of impeding or discouraging the acquisition of control of us by means of a merger, tender offer, proxy contest or otherwise, including a transaction in which our stockholders would receive a premium over the market price for their shares, and thereby protects the continuity of our management. Specifically, if in the due exercise of its fiduciary obligations, the Board of Directors was to determine that a takeover proposal was not in our best interest, shares could be issued by the Board of Directors without stockholder approval in one or more transactions that might prevent or render more difficult or costly the completion of the takeover by:

·	diluting the voting or other rights of the proposed acquirer or insurgent stockholder group;

·	putting a substantial voting block in institutional or other hands that might undertake to support the incumbent board of directors; or

·	effecting an acquisition that might complicate or preclude the takeover.

The Delaware Corporations and Associations Act (“Delaware Corporate Law”), with certain exceptions, permits a Delaware corporation to indemnify a present or former director or officer of the corporation (and certain other persons serving at the request of the corporation in related capacities) for liabilities, including legal expenses, arising by reason of service in such capacity if such person shall have acted in good faith and in a manner he reasonably believed to be in, or not opposed, to the best interests of the corporation, and in any criminal proceeding if such person had no reasonable cause to believe his conduct was unlawful. However, in the case of actions brought by or in the right of the corporation, no indemnification may be made with respect to any matter as to which such director or officer shall have been adjudged liable, except in certain limited circumstances.

Our Second Amended and Restated Articles of Incorporation provide that we shall indemnify our directors and executive officers to the fullest extent now or hereafter permitted by Delaware Corporate Law. The indemnification provided by Delaware Corporate Law and our Second Amended and Restated Certificate of Incorporation is not exclusive of any other rights to which a director or officer may be entitled. The general effect of the foregoing provisions may be to reduce the circumstances under which an officer or director may be required to bear the economic burden of the foregoing liabilities and expense.

We may also purchase and maintain insurance for the benefit of any director or officer that may cover claims for which we could not indemnify such person.

Insofar as indemnification for liabilities arising under the Securities Act of 1933 (the “Securities Act”) may be permitted to our directors, officers and controlling persons, we have been advised that, in the opinion of the SEC, such indemnification is against public policy as expressed in the Securities Act and is, therefore, unenforceable.

In the event that a claim for indemnification against such liabilities is asserted by one of our directors, officers, or controlling persons in connection with the securities being registered, we will, unless in the opinion of our legal counsel the matter has been settled by controlling precedent, submit the question of whether such indemnification is against public policy to court of appropriate jurisdiction. We will then be governed by the court's decision.

LEGAL MATTERS

The validity of our common stock offered hereby will be passed upon for us by Gracin & Marlow, LLP, New York, New York.

Table of Contents

WHERE YOU CAN FIN D MORE INFORMATION

We have filed with the SEC a registration statement on Form S-1 under the Securities Act for the common stock offered under this prospectus. It is our intent to become a reporting company under the Exchange Act, upon effectiveness of this prospectus. You may obtain reports, proxy statements and other information filed by Caldera Pharmaceuticals, Inc. with the SEC at the SEC’s Public Reference Room at 100 F Street, N.W., Washington, D.C. 20549. You may obtain information on the operation of the Public Reference Room by calling the Commission at 1-800-SEC-0330.

The SEC also maintains a website that contains reports, proxy statements, information statements and other information concerning Internal Fixation Systems, Inc. located at http://www.sec.gov. This prospectus does not contain all the information required to be in the registration statement (including the exhibits), which we have filed with the SEC under the Securities Act and to which reference is made in this prospectus.

Table of Contents

7900 Glades Road., Suite 540

Boca Raton, Florida 33434

Tel. 561-886-4200

Fax. 561-886-3330

e-mail:info@sherbcpa.com

Offices in New York and Florida

Certified Public Accountants

INDEPENDENT AUDITORS’ REPORT

To the Board of Directors

Caldera Pharmaceuticals, Inc.

We have audited the accompanying balance sheets of Caldera Pharmaceuticals, Inc. as of December 31, 2011 and 2010 and the related statements of operations and changes in stockholders’ equity, and cash flows for the years then ended. These financial statements are the responsibility of the Company's management. Our responsibility is to express an opinion on these financial statements based on our audits.

We conducted our audits in accordance with the standards of the Public Company Accounting Oversight Board (United States). Those standards require that we plan and perform the audit to obtain reasonable assurance about whether the financial statements are free of material misstatement. The Company is not required to have, nor were we engaged to perform, an audit of its internal control over financial reporting. Our audit included consideration of internal control over financial reporting as a basis for designing audit procedures that are appropriate in the circumstances, but not for the purpose of expressing an opinion on the effectiveness of the Company's internal control over financial reporting. Accordingly we express no such opinion. An audit includes examining, on a test basis, evidence supporting the amounts and disclosures in the financial statements. An audit also includes assessing the accounting principles used and significant estimates made by management, as well as evaluating the overall financial statement presentation. We believe that our audits provide a reasonable basis for our opinion.

In our opinion, the financial statements referred to above present fairly, in all material respects, the financial position of Caldera Pharmaceuticals, Inc. as of December 31, 2011 and 2010 and the results of their operations and their cash flows for the years then ended in conformity with accounting principles generally accepted in the United States of America.

The accompanying financial statements have been prepared assuming that the Company will continue as a going concern. As discussed in Note 3 to the consolidated financial statements, the Company has suffered losses from operations, has a stockholder’s deficit and has a negative working capital all of which raise substantial doubt about the Company’s ability to continue as a going concern. Management’s plans in regards to these matters are also described in Note 3. The financial statements do not include any adjustments that might result from the outcome of this uncertainty.

	/s/ Sherb & Co., LLP
	Certified Public Accountants

Boca Raton, Florida

April 20, 2012

CALDERA PHARMACEUTICALS, INC.

CONSOLIDATED BALANCE SHEETS

	December 31, 2011			December 31, 2010
ASSETS

Current assets:
Cash	$	678,300		$	117,910
Accounts receivable, net		30,505			264,488
Prepaid expenses		15,616			3,010

Total current assets		724,421			385,408

Non-current assets:
Intangible assets, net		1,044,919			1,128,485
Plant and equipment, net		243,778			255,105

		1,288,697			1,383,590

TOTAL ASSETS	$	2,013,118		$	1,768,998

LIABILITIES AND STOCKHOLDERS’ (DEFICIT)/EQUITY

Current liabilities:
Accounts payable	$	572,715		$	290,891
Other payables and accrued expenses		146,823			125,604
Loans payable		29,748			116,084
Loans from related parties		-			77,600
Dividends payable		87,457			-
Derivative financial liability		600,000			600,000

Total current liabilities		1,436,743			1,210,179

Non-current liabilities:
Loans payable		241,204			270,952

		241,204			270,952

TOTAL LIABILITIES		1,677,947			1,481,131

Convertible Redeemable Preferred Stock
Series “A” Convertible Redeemable Preferred Stock, $0.001 par value, Authorized: 500 000 shares, 331,519 shares issued and outstanding at of December 31, 2011, liquidation preference is $5.70 per share.		2,005,035			-

STOCKHOLDERS (DEFICIT)/EQUITY:
Common stock, $0.001 par value, authorized 50,000,000 shares and 10,000,000, and, 4,945,620 and 4,886,065 shares issued and, 4,291,620 and 4,886,065 outstanding as of December 31, 2011 and 2010, respectively.		4,946			4,886
Additional paid in capital		4,542,646			4,112,317
Treasury stock, at cost		(473	)		-
Accumulated deficit		(6,216,983	)		(3,829,336	)

Total stockholder’s (deficit)/equity		(1,669,864	)		287,867

TOTAL LIABILITIES AND STOCKHOLDERS (DEFICIT)/EQUITY	$	2,013,118		$	1,768,998

See notes to the financial statements on pages 5 through 25

F-1

CALDERA PHARMACEUTICALS, INC.

CONSOLIDATED STATEMENTS OF OPERATIONS

	Year ended December 31, 2011			Year ended December 31, 2010

Sales	$	554,804		$	1,641,582

Cost of sales		342,850			760,728

Gross profit		211,954			880,854

Operating expenses:
Selling, general and administrative expenses		2,238,810			1,609,847
Depreciation		67,383			64,012
Amortization		83,566			83,566
Total operating expenses		2,389,759			1,757,425

Operating loss		(2,177,805	)		(876,571	)

Other income/(expense)
Other income		8,283			-
Interest income		1,093			9
Interest expense		(16,376	)		(20,203	)

Total other income/(expense)		(7,000	)		(20,194	)

Loss before income tax		(2,184,805	)		(896,765	)

Provision for income taxes		-			-

Net loss		(2,184,805	)		(896,765	)

Deemed preferred stock dividends		(115,385	)		-
Preferred stock dividends		(87,457	)		-

Net loss applicable to common stock	$	(2,387,647	)	$	(896,765	)

Net loss per common stock: -
Basic and diluted	$	(0.50	)	$	(0.20	)

Weighted average number of common stock outstanding: -
Basic and diluted		4,802,329			4,549,502

See notes to the financial statements on pages 5 through 25

F-2

CALDERA PHARMACEUTICALS, INC.

CONSOLIDATED STATEMENT OF CHANGES IN STOCKHOLDER’S EQUITY

	Common Stock					Treasury stock
	Number of shares			Amount		Amount			Additional Paid-in capital		Accumulated deficit			Total Stockholder’s Equity

Balance at January 1, 2010		4,471,565		$	4,472	$	-		$	3,578,187	$	(2,932,571	)	$	650,088

Stock issued in terms of settlement agreement between shareholders during October 2010		90,000			90		-			33,950		-			34,040

Issuance of common stock as compensation for consulting fees		324,500			324		-			178,152		-			178,476

Fair value of stock options issued to employees		-			-		-			322,028		-			322,028

Net loss		-			-		-			-		(896,765	)		(896,765	)

Balance at December 31, 2010		4,886,065			4,886		-			4,112,317		(3,829,336	)		287,867

Stock options exercised		9,555			10		-			54,549		-			54,559

Issuance of common stock as compensation for consulting fees		50,000			50		-			27,450		-			27,500

Fair value of stock options issued to employees		-			-		-			342,342		-			342,342

Fair value of warrants issued for consulting fees		-			-		-			5,988		-			5,988

Treasury stock purchased		(654,000	)		-		(473	)		-		-			(473	)

Net loss		-			-		-			-		(2,184,805	)		(2,184,805	)

Deemed preferred stock dividend		-			-		-			-		(115,385	)		(115,385	)

Preferred stock dividend		-			-		-			-		(87,457	)		(87,457	)

Balance at December 31, 2011		4,291,620		$	4,946	$	(473	)	$	4,542,646	$	(6,216,983	)	$	(1,669,864	)

See notes to the financial statements on pages 5 through 25

F-3

CALDERA PHARMACEUTICALS, INC.

CONSOLIDATED STATEMENTS OF CASH FLOWS

	Year ended December 31, 2011			Year ended December 31, 2010

Cash flow from operating activities
Net loss	$	(2,184,805	)	$	(896,765	)
Adjustments for non-cash items:
Depreciation		67,383			64,012
Amortization		83,566			83,566
Stock based compensation payments		375,830			500,504

Changes in operating assets and liabilities:
Decrease/(increase) in accounts receivable		233,983			(30,368	)
(Increase)/decrease in prepaid expenses		(12,606	)		43,718
Increase in accounts payable		281,824			233,138
Increase in other payables and accrued expenses		21,219			15,524

Net cash (utilized)/provided by operating activities		(1,133,606	)		13,329

Investing activities
Purchase of plant and equipment		(56,056	)		(6,144	)

Net cash used in investing activities		(56,056	)		(6,144	)

Financing activities
Advance on line of credit, net		-			35,997
Repayment of line of credit		(87,784	)		-
Repayment of loan payable		(28,300	)		(30,469	)
Repayment of stockholders loan		(77,600	)		(7,339	)
Loan advanced by stockholder		-			66,600
Proceeds on Series “A” Preferred stock issued		1,889,650			-
Proceeds on Common stock options exercised		54,559			-
Treasury stock purchases		(473	)		-

Net cash provided by financing activities		1,750,052			64,789

Net increase in cash		560,390			71,974

Cash at the beginning of the period		117,910			45,936

Cash at the end of the period	$	678,300		$	117,910

Supplemental disclosure of cash flow information
Cash paid for:
Interest	$	16,376		$	20,203

Non cash investing and financing activities:
Common stock issued for settlement of debt	$	-		$	34,040

See notes to the financial statements on pages 5 through 25

F-4

CALDERA PHARMACEUTICALS, INC.

NOTES TO THE CONSOLIDATED FINANCIAL STATEMENTS

1.	GENERAL INFORMATION

Caldera Pharmaceuticals, Inc. (“the Company”) is a Delaware corporation with principal offices in Los Alamos, New Mexico and Chicago, Illinois. The Company was incorporated in November 2003.

The Company is a drug discovery and pharmaceutical instrument company that is based on a proprietary x-ray fluorescence technology, called XRpro®. Caldera offers what it believes to be uniquely broad and simple technologies to evaluate drug molecules, which increases the efficiency of analyzing and evaluating drug molecules for safety and efficacy at an early and less expensive stage.

The Company has generated the majority of its revenues to date through Government research contracts and Government grants utilizing its proprietary x-ray fluorescence technology.

2.	ACCOUNTING POLICIES AND ESTIMATES

Basis of Presentation

The accompanying financial statements have been prepared in conformity with accounting principles generally accepted in the United States of America (“US GAAP”).

Consolidation

The consolidated financial statements include the financial statements of the Company and its subsidiaries in which it has a majority voting interest. Investments in affiliates are accounted for under the cost method of accounting, where appropriate. All significant inter-company accounts and transactions have been eliminated in the consolidated financial statements. The entities included in these consolidated financial statements are as follows:

Caldera Pharmaceuticals, Inc (Parent Company)

XRpro Corp.

Estimates

The preparation of these financial statements in accordance with US GAAP requires us to make estimates and judgments that affect the reported amounts of assets, liabilities, revenues and expenses, and related disclosure of contingent assets and liabilities. We continually evaluate our estimates, including those related to bad debts, inventories, and recovery of long-lived assets. We base our estimates on historical experience and on various other assumptions that we believed to be reasonable under the circumstances, the results of which form the basis for making judgments about the carrying values of assets and liabilities that are not readily apparent from other sources. Any future changes to these estimates and assumptions could cause a material change to our reported amounts of revenues, expenses, assets and liabilities. Actual results may differ from these estimates under different assumptions or conditions. We believe the following critical accounting policies affect our more significant judgments and estimates used in the preparation of the financial statements. Significant estimates include the allowance for doubtful accounts, the allowance for obsolete inventory, the useful life of property and equipment and intangible assets, and assumptions used in assessing impairment of long-term assets.

All amounts referred to in the notes to the financial statements are in United States Dollars ($) unless stated otherwise.

F-5

CALDERA PHARMACEUTICALS, INC.

NOTES TO THE CONSOLIDATED FINANCIAL STATEMENTS

2.	ACCOUNTING POLICIES AND ESTIMATES (continued)

Contingencies

Loss contingencies considered to be remote by management are generally not disclosed unless they involve guarantees, in which case the guarantee would be disclosed.

Fair value of financial instruments

The Company adopted the guidance of Accounting Standards Codification (“ASC”) 820 for fair value measurements which clarifies the definition of fair value, prescribes methods for measuring fair value, and establishes a fair value hierarchy to classify the inputs used in measuring fair value as follows:

Level 1-Inputs are unadjusted quoted prices in active markets for identical assets or liabilities available at the measurement date.

Level 2-Inputs are unadjusted quoted prices for similar assets and liabilities in active markets, quoted prices for identical or similar assets and liabilities in markets that are not active, inputs other then quoted prices that are observable, and inputs derived from or corroborated by observable market data.

Level 3-Inputs are unobservable inputs which reflect the reporting entity’s own assumptions on what assumptions the market participants would use in pricing the asset or liability based on the best available information.

The carrying amounts reported in the balance sheets for cash, accounts receivable, loans payable, accounts payable and accrued expenses, and advances to suppliers approximate their fair market value based on the short-term maturity of these instruments. The Company did not identify any assets or liabilities that are required to be presented on the balance sheets at fair value in accordance with the accounting guidance.

ASC 825-10 “ Financial Instruments ” allows entities to voluntarily choose to measure certain financial assets and liabilities at fair value (fair value option). The fair value option may be elected on an instrument-by-instrument basis and is irrevocable, unless a new election date occurs. If the fair value option is elected for an instrument, unrealized gains and losses for that instrument should be reported in earnings at each subsequent reporting date. The Company did not elect to apply the fair value option to any outstanding instruments.

F-6

CALDERA PHARMACEUTICALS, INC.

NOTES TO THE CONSOLIDATED FINANCIAL STATEMENTS

2.	ACCOUNTING POLICIES AND ESTIMATES (continued)

Recent accounting pronouncements

In October 2009, the FASB issued ASU No. 2009-14, “Certain Revenue Arrangements That Include Software Elements.” This ASU changes the accounting model for revenue arrangements that include both tangible products and software elements that are “essential to the functionality,” and scopes these products out of current software revenue guidance. The new guidance will include factors to help companies determine what software elements are considered “essential to the functionality.” The amendments will now subject software-enabled products to other revenue guidance and disclosure requirements, such as guidance surrounding revenue arrangements with multiple-deliverables. The amendments in this ASU are effective prospectively for revenue arrangements entered into or materially modified in the fiscal years beginning on or after June 15, 2010. Early application is permitted. The adoption of the new ASU did not have any important impact on the Company’s financial statements.

In January 2010, the FASB issued guidance to amend the disclosure requirements related to fair value measurements. The guidance requires the disclosure of roll forward activities on purchases, sales, issuance, and settlements of the assets and liabilities measured using significant unobservable inputs (Level 3 fair value measurements). The guidance became effective for us with the reporting period beginning July 1, 2011. Other than requiring additional disclosures, the adoption of this new guidance will not have a material impact on our financial statements.

In January 2010, the FASB issued Accounting Standards Update ("ASU") No. 2010-06 for Fair Value Measurements and Disclosures (Topic 820): Improving Disclosures about Fair Value Measurements . This Update requires new disclosures for transfers in and out of Level 1 and 2 and activity in Level 3. This Update also clarifies existing disclosures for level of disaggregation and requires additional disclosures about inputs and valuation techniques. The new disclosures are effective for interim and annual periods beginning after December 15, 2009, except for the Level 3 disclosures, which are effective for fiscal years beginning after December 15, 2010 and for interim periods within those years. Other than requiring additional disclosures, adoption of this new guidance did not have a material impact on the Company's financial statements and is not expected to have a significant impact on the reporting of the Company's financial condition or results of operations.

In February 2010, the FASB (Financial Accounting Standards Board) issued Accounting Standards Update 2010-09 (ASU 2010-09), Subsequent Events (Topic 855): Amendments to Certain Recognition and Disclosure Requirements. This amendment addresses both the interaction of the requirements of this Topic with the SEC’s reporting requirements and the intended breadth of the reissuance disclosure provision related to subsequent events (paragraph 855-10-50-4). All of the amendments in this Update are effective upon issuance of the final Update, except for the use of the issued date for conduit debt obligors. That amendment is effective for interim or annual periods ending after June 15, 2010. The adoption of the new ASU did not have any important impact on the Company’s financial statements.

In March 2010, the FASB ratified the milestone method of revenue recognition. Under this standard, an entity can recognize contingent consideration earned from the achievement of a substantive milestone in its entirety in the period in which the milestone is achieved. A milestone is defined as an event (i) that can only be achieved based in whole or in part on either the entity's performance or on the occurrence of a specific outcome resulting from the entity's performance (ii) for which there is substantive uncertainty at the date the arrangement is entered into that the event will be achieved and (iii) that would result in additional payments being due to the entity. This guidance is effective for years beginning after June 15, 2010. This guidance did not have any important impact on the Company’s financial statements.

In March 2010, the FASB issued ASU 2010-11, Derivatives and Hedging (Topic 815): Scope Exception Related to Embedded Credit Derivatives. The amendments in this Update are effective for each reporting entity at the beginning of its first fiscal quarter beginning after June 15, 2010. Early adoption is permitted at the beginning of each entity’s first fiscal quarter beginning after issuance of this Update. The Company does not expect the provisions of ASU 2010-11 to have a material effect on the financial position, results of operations or cash flows of the Company.

F-7

CALDERA PHARMACEUTICALS, INC.

NOTES TO THE CONSOLIDATED FINANCIAL STATEMENTS

2.	ACCOUNTING POLICIES AND ESTIMATES (continued)

Recent accounting pronouncements (continued)

In April 2010, the FASB issued ASU 2010-13, Compensation-Stock Compensation (Topic 718): Effect of Denominating the Exercise Price of a Share-Based Payment Award in the Currency of the Market in Which the Underlying Equity Security Trades – a consensus of the FASB Emerging Issues Task Force. The amendments in this Update are effective for fiscal years, and interim periods within those fiscal years, beginning on or after December 15, 2010. Earlier application is permitted. The Company does not expect the provisions of ASU 2010-13 to have a material effect on the financial position, results of operations or cash flows of the Company.

In May 2010, the FASB issued ASU 2010-19, Foreign Currency (Topic 830): Foreign Currency Issues: Multiple Foreign Currency Exchange Rates. The amendments in this Update are effective as of the announcement date of March 18, 2010. The Company does not expect the provisions of ASU 2010-19 to have a material effect on the financial position, results of operations or cash flows of the Company.

In May 2011, the FASB issued guidance to amend the accounting and disclosure requirements on fair value measurements. The new guidance limits the highest-and-best-use measure to nonfinancial assets, permits certain financial assets and liabilities with offsetting positions in market or counterparty credit risks to be measured at a net basis, and provides guidance on the applicability of premiums and discounts. Additionally, the new guidance expands the disclosures on Level 3 inputs by requiring quantitative disclosure of the unobservable inputs and assumptions, as well as description of the valuation processes and the sensitivity of the fair value to changes in unobservable inputs. The new guidance will be effective for us beginning January 1, 2012. Other than requiring additional disclosures, we do not anticipate material impacts on our financial statements upon adoption.

In June 2011, the FASB issued guidance on presentation of comprehensive income. The new guidance eliminates the current option to report other comprehensive income and its components in the statement of changes in equity. Instead, an entity will be required to present either a continuous statement of net income and other comprehensive income or in two separate but consecutive statements. The new guidance will be effective for us beginning July 1, 2012 and will have presentation changes only.

Other accounting standards that have been issued or proposed by FASB that do not require adoption until a future date are not expected to have a material impact on the consolidated financial statements upon adoption.

Reporting by segment

No segmental information is presented as the Company only has one significant reporting segment that is Government Revenues.

Intangible assets

a)	License Agreements

License agreements acquired by the Company are reported at acquisition value less accumulated amortization and impairments.

b)	Amortization

As sessment of an intangible asset’s residual value and useful life is performed annually.

F-8

CALDERA PHARMACEUTICALS, INC.

NOTES TO THE CONSOLIDATED FINANCIAL STATEMENTS

2.	ACCOUNTING POLICIES AND ESTIMATES (continued)

Plant and equipment

Leasehold improvements	5 Years
Laboratory equipment	7 Years
Furniture and fixtures	10 Years
Computer equipment	3 Years

Concentrations of credit risk

The Company’s operations are carried out in the USA. Accordingly, the Company’s business, financial condition and results of operations may be influenced by the political, economic and legal environment in the USA and by the general state of the economy. The Company’s results may be adversely affected by changes in governmental policies with respect to laws and regulations, anti-inflationary measures, and rates and methods of taxation, among other things.

Concentration of major customers

The Company currently derives substantially all of its revenues from Government research contracts and Government grants.

These Government research contracts are primarily from two government agencies, The Department of Defense and the National Institutes of Health. In addition to this, Federal grants under the Qualifying Therapeutic Discovery Project Credit were also received in 2011 and 2010.

Revenues by major customer type are as follows:

	December 31, 2011		December 31, 2010

Department of Defense	$	173,242	$	1,028,809
National Institutes of Health		312,874		406,983
Federal Government Grants		38,688		205,790
Other		30,000		-

	$	554,804	$	1,641,582

Accounts receivable and other receivables

We have a policy of reserving for uncollectible accounts based on our best estimate of the amount of probable credit losses in our existing accounts receivable. We periodically review our accounts receivable and other receivables to determine whether an allowance is necessary based on an analysis of past due accounts and other factors that may indicate that the realization of an account may be in doubt. Account balances deemed to be uncollectible are charged to the allowance after all means of collection have been exhausted and the potential for recovery is considered remote.

F-9

CALDERA PHARMACEUTICALS, INC.

NOTES TO THE CONSOLIDATED FINANCIAL STATEMENTS

The balance of the bad debt provision as at December 31, 2011 and 2010 was $0. The amount charged to bad debt provision for the years ended December 31, 2011 and 2010 was $0.

As a basis for accurately estimating the likelihood of collection has been established, we consider a number of factors when determining reserves for uncollectable accounts. We believe that we use a reasonably reliable methodology to estimate the collectability of our accounts receivable. We review our allowances for doubtful accounts on a regular basis. We also consider whether the historical economic conditions are comparable to current economic conditions. If the financial condition of our customers or other parties that we have business relations with were to deteriorate, resulting in an impairment of their ability to make payments, additional allowances may be required.

Cash and cash equivalents

For purposes of the statements of cash flows, the Company considers all highly liquid instruments purchased with a maturity of three months or less and money market accounts to be cash equivalents. The Company maintains cash and cash equivalents with two financial institutions in the USA.

Revenue recognition

Revenue sources consist of government grants, government contracts and commercial development contracts.

Revenues are recognized in accordance with the terms of the award and the government agency. Grant revenue is recognized in one of two different ways depending on the grant. Cost reimbursement grants require us to submit proof of costs incurred that are invoiced by us to the government agency, which then pays the invoice. In this case, grant revenue is recognized during the period that the costs were incurred according to the terms of the government grant. Fixed cost grants require no proof of costs at the time of invoicing, but proof is required for audit purposes and grant revenue is recognized during the period that the costs were incurred according to the terms of the government grant. The grant revenue under these fixed costs grants is recognized using a percentage-of-completion method, which uses assumptions and estimates. These assumptions and estimates are developed in coordination with the principal investigator performing the work under the government fixed-cost grants to determine key milestones, expenses incurred, and deliverables to perform a percentage-of-completion analysis to ensure that revenue is appropriately recognized. Critical estimates involved in this process include total costs incurred and anticipated to be incurred during the remaining life of the grant.

Commercial revenue is recognized when the service or development is delivered or upon complying with the relevant terms of the commercial agreement.

Sales and Marketing

Sales and marketing expenses are minimal at present. These costs, if any, are expensed as incurred and included in Selling, general and administrative expenses. The Company expects to incur substantial sales and marketing expenses in future periods to promote its x-ray florescence equipment to drug discovery enterprises.

F-10

CALDERA PHARMACEUTICALS, INC.

NOTES TO THE CONSOLIDATED FINANCIAL STATEMENTS

2.	ACCOUNTING POLICIES AND ESTIMATES (continued)

Research and Development

The remuneration of the Company’s research and development staff, materials used in internal research and development activities, and payments made to third parties in connection with collaborative research and development arrangements, are all expensed as incurred. Where the company makes a payment to a third party to acquire the right to use a product formula which has received regulatory approval, that payment is accounted for as the acquisition of a license or patent and is capitalized as an intangible asset and amortized over the shorter of the remaining license period or patent life.

The amount expensed for unrecovered research costs, included in selling, general and administrative expenses during the year ended December 31, 2011was $113,276.

Patent Costs

Legal costs in connection with approved patents and patent applications are expensed as incurred and classified as selling, general and administrative expense in our consolidated statement of operations.

Share-Based Compensation

Share-based compensation cost is measured at the grant date, based on the estimated fair value of the award and is recognized as expense over the employee's requisite service period on a straight-line basis. Share-based compensation expense recognized in the consolidated statements of operations for the years ended December 31, 2011 and 2010 is based on awards ultimately expected to vest and has been reduced for estimated forfeitures. This estimate will be revised in subsequent periods if actual forfeitures differ from those estimates. We have no awards with market or performance conditions.

Income Taxes

The Company utilizes SFAS No. 109, Accounting for Income Taxes, included in the Codification as ASC 740, Income Taxes, which requires the recognition of deferred tax assets and liabilities for the expected future tax consequences of events that have been included in the financial statements or tax returns. Under this method, deferred income taxes are recognized for the tax consequences in future years of differences between the tax bases of assets and liabilities and their financial reporting amounts at each period end based on enacted tax laws and statutory tax rates applicable to the periods in which the differences are expected to affect taxable income. Valuation allowances are established, when necessary, to reduce deferred tax assets to the amount expected to be realized.

Net Loss per Share

Basic net loss per share is computed on the basis of the weighted average number of common stock outstanding during the period.

Diluted net income per share is computed on the basis of the weighted average number of common stock and common stock equivalents outstanding. Dilutive securities having an anti-dilutive effect on diluted net income per share are excluded from the calculation.

Dilution is computed by applying the treasury stock method for options and warrants. Under this method, options and warrants are assumed to be exercised at the beginning of the period (or at the time of issuance, if later), and as if funds obtained thereby were used to purchase common stock at the average market price during the period.

Dilution is computed by applying the if-converted method for convertible preferred stocks. Under this method, convertible preferred stock is assumed to be converted at the beginning of the period (or at the time of issuance, if later), and preferred dividends (if any) will be added back to determine income applicable to common stock. The shares issuable upon conversion will be added to weighted average number of common stock outstanding. Conversion will be assumed only if it reduces earnings per share (or increases loss per share).

F-11

CALDERA PHARMACEUTICALS, INC.

NOTES TO THE CONSOLIDATED FINANCIAL STATEMENTS

2.	ACCOUNTING POLICIES AND ESTIMATES (continued)

Comprehensive income

Comprehensive income is defined as the change in equity of a company during a period from transactions and other events and circumstances excluding transactions resulting from investments from owners and distributions to owners. For the Company, comprehensive income for the periods presented includes net income.

Related parties

Parties are considered to be related to the Company if the parties that, directly or indirectly, through one or more intermediaries, control, are controlled by, or are under common control with the Company. Related parties also include principal owners of the Company, its management, members of the immediate families of principal owners of the Company and its management and other parties with which the Company may deal if one party controls or can significantly influence the management or operating policies of the other to an extent that one of the transacting parties might be prevented from fully pursuing its own separate interests. The Company shall disclose all related party transactions. All transactions shall be recorded at fair value of the goods or services exchanged. Property purchased from a related party is recorded at the cost to the related party and any payment to or on behalf of the related party in excess of the cost is reflected as a distribution to related party.

3.	GOING CONCERN

As shown in the accompanying financial statements, the Company incurred a net loss of $2,387,647 and $896,765 during the years ended December 31, 2011 and 2010, respectively. As of December 31, 2011, the Company had an accumulated deficit of $6,216,983. The Company had a working capital deficiency of $112,322, after excluding the derivative liability of $600,000, at December 31, 2011. These operating losses and working capital deficiency create an uncertainty about the Company’s ability to continue as a going concern. Although no assurances can be given, management of the Company believes that potential additional issuances of equity or other potential financing will provide the necessary funding for the Company to continue as a going concern. The financial statements do not include any adjustments that might be necessary if the Company is unable to continue as a going concern. The Company is economically dependent upon future capital contributions or financing to fund ongoing operations.

4.	INTANGIBLE ASSETS

Licenses

In terms of an Exclusive Patent License agreement covering national and international patents entered into with the Los Alamos National Security LLC. Dated September 8, 2005, the Company has the exclusive right to the use of certain patents covering the following:

·	Method for Detecting Binding Events Using Micro X-Ray Fluorescence Spectrometry;

·	Flow Method and Apparatus for Screening Chemicals Using Micro X-Ray Fluorescence;

·	Method and Apparatus for Detecting Chemical Binding;

·	Drug Development and Manufacturing.

The agreement provides for a term as long as the last surviving patent which is generally a twenty year period from the date of first application.

F-12

CALDERA PHARMACEUTICALS, INC.

NOTES TO THE CONSOLIDATED FINANCIAL STATEMENTS

4.	INTANGIBLE ASSETS (continued)

In terms of the agreement, The Company issued shares to the Licensor equal to 3% of the issued equity of the Company. The agreement contains anti-dilutive clauses that will ensure that the Licensor maintains at least a 3% shareholding in the Company until the Company achieves equity financing of at least $20 million. As of December 31, 2011, the Company has not yet raised the requisite amount of financing. The Licensor continued to hold, at a minimum 3% of the Company’s common stock. The company accounted for the anti-dilution clause in terms of FASB ASC 505 – 50, refer note 7, Derivative financial liability below.

The agreement has termination provisions as follows; i) at the option of the Licensor; If the Company fails to deliver any reports that are due, fails to pay any royalties or fees due, breaches any material clause of the agreement, or failure to inform the Licensor of a petition to file for voluntary or involuntary bankruptcy; ii) at the option of the Licensee by giving 90 days written notice to the Licensor.

The agreement further provides for an annual royalty to be paid to the Licensee at a rate of 2% per annum on net sales, excluding any sales to Government agencies. The agreement provided for a minimum fee payment of $25,000 per annum for the financial years ended December 31, 2006 to December 31, 2010. Thereafter the minimum fee payment increases to $50,000 per annum up until December 31, 2022. The fee will be deducted from any royalties due in excess of the fee due for that financial year.

Future annual minimum payments required under license agreement obligations at December 31, 2011, are as follows:

	Amount

2012	$	50,000
2013		50,000
2014		50,000
2015		50,000
2016 and thereafter		350,000

Total	$	550,000

Licenses consist of the following at December 31, 2011 and 2010:

	December 31, 2011			December 31, 2010

Licenses, at cost	$	1,572,000		$	1,572,000
Less: Accumulated amortization		(527,081	)		(443,515	)

	$	1,044,919		$	1,128,485

The aggregate amortization expense charged to operations was $83,566 and $83,566 for the years ended December 31, 2011 and 2010, respectively. The amortization policies followed by the company are described in Note (2).

F-13

CALDERA PHARMACEUTICALS, INC.

NOTES TO THE CONSOLIDATED FINANCIAL STATEMENTS

4.	INTANGIBLE ASSETS (continued)

Amortization expense for the future years is summarized as follows:

	Amount

2012	$	83,566
2013		83,566
2014		83,566
2015		83,566
2016		83,566
2017 and thereafter		627,089
Total	$	1,044,919

Patents

The Company has various patents pending or registered in its name. These patents have been internally generated and all costs associated with the research and development of these patents has been expensed.

The patents assigned to Caldera are as follows:

·	Well Plate – apparatus for preparing samples for measurement by x-ray fluorescence spectrometry. Patent filed August 15, 2008

·	Method and Apparatus for measuring Protein Post Translational Modification. Patent filed September 26, 2008.

·	Method and Apparatus for Measuring Analyte Transport across barriers. Patent filed July 1, 2009.

5.	PLANT AND EQUIPMENT

Plant and equipment consists of the following at December 31, 2011 and 2010.

	December 31, 2011			December 31, 2010

Leasehold improvements	$	6,393		$	6,393
Furniture and fittings		7,114			7,114
Laboratory equipment		462,434			413,269
Computer equipment		29,330			22,439

Total		505,271			449,215
Accumulated depreciation		(261,493	)		(194,110	)
	$	243,778		$	255,105

The aggregate depreciation charge to operations was $67,383 and $64,012 for the years ended December 31, 2011 and 2010 respectively. The depreciation policies followed by the company are described in Note (2).

F-14

CALDERA PHARMACEUTICALS, INC.

NOTES TO THE CONSOLIDATED FINANCIAL STATEMENTS

6.	OTHER PAYABLES AND ACCRUED EXPENSES

	December 31, 2011		December 31, 2010

Credit card liabilities	$	15,750	$	2,342
Vacation and Sick Pay accrual		100,771		85,228
Payroll liabilities		28,202		28,489
Other		2,100		9,545

	$	146,823	$	125,604

7.	DERIVATIVE FINANCIAL LIABILITY

The Company has a potential liability to issue additional shares of common stock to Los Alamos National Security, LLC. (“LANS”), in terms of an anti dilution clause which maintains LANS shareholding at 3% of the Company’s issued common stock until the Company achieves equity financing of $20.0 million. The Company adopted and treated this transaction under the provisions of FASB ASC 505-50, which establishes accounting for equity-based payments to non-employees. FASB ASC505-50-55-14, specifically, relates to transactions that are triggered only by a Market Condition and measures the commitment to potentially issue the additional equity instruments at fair value. In the absence of being able to apply a market price to the number of shares the Company calculated the maximum commitment, should the Market Condition be met.

The Company capitalized an additional $600,000 of costs relating to the application of the above provisions as part of intangible assets (See Intangible Footnote #4 above). The Company continually evaluates whether events or circumstances have occurred that indicate the remaining useful life of these costs should be revised or the remaining balance of such assets may not be recoverable.

F-15

CALDERA PHARMACEUTICALS, INC.

NOTES TO THE CONSOLIDATED FINANCIAL STATEMENTS

8.	INCOME TAXES

Due to our historical net loss position, and valuation allowance against deferred tax assets, there is no provision or benefit for income taxes recorded for the years ended December 31, 2011 and 2010.

The income tax provision/ (benefit) is different from that which would be obtained by applying the statutory Federal income tax rate of 35% to income before income tax expense. The items causing this difference for the years ended December 31, 2011 and 2010 are as follows:

	December 31, 2011			December 31, 2010

Income tax benefit at federal statutory rate	$	(764,682	)	$	(302,709	)
State taxes, net of federal benefit		(109,240	)		(43,244	)
Other		3,100			(53,748	)
Stock based compensation		150,322			200,201
		(720,500	)		(199,500	)
Valuation allowances		720,500			199,500
	$	-		$	-

Deferred income taxes reflect the net tax effect of temporary differences between the carrying amount of assets and liabilities for financial reporting purposes and the amounts used for income tax purposes. Significant components of deferred tax assets and liabilities at December 31, 2011 and 2010 are as follows:

	December 31, 2011			December 31, 2010
Deferred tax assets
Accrual to cash adjustments	$	269,000		$	60,000
Plant and equipment		21,000			10,500
Net operating loss		1,203,000			697,000
		1,493,000			767,500
Valuation allowance		(1,416,000	)		(695,500	)
Net Amortization		77,000			72,000
Deferred tax liabilities
Accrual to cash adjustments		(77,000	)		(72,000	)
	$	-		$	-

We have established a valuation allowance against our gross deferred tax assets sufficient to bring our net deferred tax assets to zero due to the uncertainty surrounding the realization of such assets. Management has determined it is more likely than not that the deferred tax assets are not realizable beyond our deferred tax liabilities due to our historical loss position. The valuation allowance increased by $720,500 during 2011.

At December 31, 2011, we had tax loss carry forwards of approximately $3,008,000. These net operating loss carry forwards expire in 2031, if unused.

F-16

CALDERA PHARMACEUTICALS, INC.

NOTES TO THE CONSOLIDATED FINANCIAL STATEMENTS

8.	INCOME TAXES (continued)

Pursuant to the Internal Revenue Code of 1986, as amended, ("IRC") §382, our ability to use net operating loss carry forwards to offset future taxable income is limited if we experience a cumulative change in ownership of more than 50% within a three-year period.

The Company’s 2009 and 2010 Federal income tax returns have been examined by the Internal Revenue Service (“IRS”) and the adjustments proposed by the IRS were agreed to by the Company. The Company’s tax provision reflects the IRS’ audit adjustments and the Company believes that there are no remaining uncertain tax positions requiring recognition.

9.	LOANS PAYABLE

	December 31, 2011		December 31, 2010
Short term portion
Los Alamos County Loan	$	29,748	$	28,300
Los Alamos National Bank		-		87,784
		29,748		116,084
Long term portion
Los Alamos County Loan		241,204		270,952
	$	270,952	$	387,036

The amortization of the principal outstanding on the Los Alamos County Loan is as follows:

	Amount

2012		29,748
2013		31,270
2014		32,869
2015		34,551
2016		36,319
2017 and thereafter		106,195
Total	$	270,952

Los Alamos County Loan

The Company entered into a Project Participation Agreement (as Amended) and a Loan Agreement with the Incorporated County of Los Alamos as of September 21, 2006. The Agreement provided for funding up to a maximum of $2,200,000 for the construction of a building and purchase of equipment. The maximum amount of equipment to be funded out of the total available loan of $2,200,000 was $625,000. The term of the loan is 13 years. The loan agreement provided for no repayments for 36 months with 120 equal monthly repayments commencing on September 21, 2009. The interest rate on the loan is 5% per annum. The assets funded in terms of the Project Participation Agreement and the Loan Agreement is to be used as security for the balance of the loan outstanding.

The Company made use of the loan to purchase assets amounting to $302,009 during the 2007 financial year. Repayments of the loan commenced on September 21, 2009 at an interest rate of 5% per annum with equal monthly repayments of $3,546.87.

F-17

CALDERA PHARMACEUTICALS, INC.

NOTES TO THE CONSOLIDATED FINANCIAL STATEMENTS

9.	LOANS PAYABLE (continued)

Los Alamos National Bank

The Company entered into a one year revolving draw loan with Los Alamos National Bank as of April 23, 2009 with a principal available of $300,000. The Company drew $50,000 on the loan on April 23, 2009, a further $50,000 on May 24, 2009 a further $60,000 on June 29, 2009 and a further $40,000 on July 13, 2009. The Company made repayments on the loan on October 27, 2009 of $50,000, a further repayment of $100,000 was made on December 31, 2009 and a final repayment of $50, 000 on April 23, 2010. The loan bears interest at a coupon of the Wall Street Journal Prime rate plus 1% with a floor of 6% per annum. This loan is secured by inventory, Accounts receivable and other rights to payments, instruments, documents and other Chattel paper, general intangibles and fixed assets. Interest is payable quarterly.

The Company entered into a one year revolving draw loan with Los Alamos National Bank as of April 23, 2010 with a principal available of $300,000. The Company drew $86,800 on the loan on April 23, 2010, utilizing $50,000 to repay the balance outstanding on loan 1 above. The loan bears interest at a coupon of the Wall Street Journal Prime rate plus 1% with a floor of 6% per annum. This loan is secured by inventory, accounts receivable and other rights to payments, instruments, documents and other Chattel paper, general intangibles and fixed assets. Interest is payable quarterly.

The Los Alamos National Bank has provided a further facility to Caldera Pharmaceuticals of $750,000 as of May 23, 2011 for a period of one year. The loan bears interest at a coupon of the Wall Street Journal Prime rate plus 1% with a floor of 4.75% per annum. This loan is secured by inventory, Accounts and other rights to payments, instruments, documents and other Chattel paper, general intangibles and fixed assets. Interest is payable quarterly. No funds have been drawn under this facility during the current year.

10.	OTHER STOCKHOLDERS’ EQUITY

The authorized capital of the company was increased by 10,000,000 preferred shares of $0.001 each on March 14, 2011 in terms of a restated and amended articles of Incorporation.

Series “A” 8% Convertible Preferred Stock and Common Stock Purchase Warrants

The Company has authorized 500,000 shares of series A Preferred Stock. In terms of a private placement memorandum dated June 24, 2011, 331,519 units of series "A" convertible preferred stock (“Preferred Stock”) and common stock purchase warrants were issued to Series "A" preferred stockholders at a par value of $0.001 per share for a total consideration of $1,889,650. A further 42,800 warrants were issued to advisors to acquire shares of common stock at a price of $5.70 per share in conjunction with the private placement and a further 15,000 warrants were issued to an advisor at $2.00 per share in connection with services provided to the Company. The Preferred Stock will convert to common stock of the Company at a price of $5.70 per Common Stock subject to adjustment for stock splits, stock dividends and any further recapitalizations. The Preferred Stock is subject to voluntary conversion at the option of the stockholder at any time and is mandatory convertible at the option of the Company provided the Company’s common stock is trading on a recognized stock exchange or Over the Counter Bulletin Board and the volume weighted average price of the Company’s common stock is at least $10 per share, subject to stock splits, stock dividends and recapitalizations.

A fair market value for the common stock purchase warrants was performed using the Black-Scholes valuation model and a further $115,385 was credited to the value of the preferred stock as a deemed dividend during the 2011 year, see Note 12 below.

F-18

CALDERA PHARMACEUTICALS, INC.

NOTES TO THE CONSOLIDATED FINANCIAL STATEMENTS

10.	OTHER STOCKHOLDERS’ EQUITY (continued)

The Preferred Stock Holders will receive warrants to purchase shares of the Company’s common stock equal to 100% of the number of shares that they would receive upon conversion of the Preferred stock into common stock at an exercise price of $5.70 per share. The Warrants will expire five years after date of issuance. The Warrants are not transferable separately from the Preferred Stock without the consent of the Company and an opinion of Counsel satisfactory to the Company.

Should the Company receive net proceeds of at least $3 million from litigation proceedings against the managers of Los Alamos National Laboratory; the Preferred Stock holder will have the option to redeem the Preferred Stock equal to 130% of the price per share of $5.70. The Company also has the option to redeem the Preferred Stock at a price equal to 130% of the price per share of $5.70 at any time after giving the investors notice and allowing them to exercise their conversion rights into common stock 30 days after notice has been received. The Company is not obligated to pursue the litigation against Los Alamos National Laboratory but is doing so based on its belief that it will have a successful outcome.

The liquidation rights of the Preferred stock is the greater of $5.70 per share plus any unpaid dividends or an amount that would have been payable had all shares of Series A Preferred Stock converted into common stock immediately prior to liquidation.

The Preferred stock carries an 8% cumulative, non-compounded dividend payable on January 31, each year. In cash or in kind at the option of the Preferred Stock holder. For any other dividends or distributions, the Preferred Stock is treated on an as converted basis.

11.	COMMON STOCK

Common stock consists of 50,000,000 (2010: 10,000,000) authorized shares of $0.001 each.

The authorized common stock was increased from 10,000,000 to 50,000,000 shares of $0.001 each on March 14, 2011 in terms of a restated and amended articles of Incorporation.

In terms of settlement agreement entered into between three existing shareholders of the company and a further settlement agreement entered into between The Company and these shareholders, a further 90,000 shares were issued to two existing shareholders in exchange for their judgment and settlement agreement obtained against the third shareholder. The agreement entitled the company to repurchase 177,500 shares of common stock of the third shareholder and a forgiveness of a debt owing to the third shareholder of $34,040. The repurchase of the 177,500 shares took place during November 2011 when the Stay and Collection Judgment obtained against Caldera Pharmaceuticals by our previous legal counsel was dismissed.

A further 324,500 shares of common stock were issued for $178,475 for consulting services rendered by a third party. The consulting agreement includes business development and capital raising to fund the future expansion of the Company.

During the year ended December 31, 2011, certain employees of the Company exercised options over 9,555 shares of common stock at an exercise price of $5.71 per share totaling $54,559.

A further 50,000 shares of common stock were issued for $27,500 for consulting services rendered by a third party. The consulting agreement includes management services provided to the Company.

F-19

CALDERA PHARMACEUTICALS, INC.

NOTES TO THE CONSOLIDATED FINANCIAL STATEMENTS

11.	COMMON STOCK (continued)

During November 2011 the Company repurchased 472,500 shares of common stock from a previous shareholder who failed to fulfill the agreement to provide funding for the business. The stock was repurchased for $472.

During December 2011, a settlement agreement was reached with a shareholder who has sued the Company and the Company had in turn counter-sued the shareholder. In terms of the agreement, the total shareholding of 8,000 shares of common stock was repurchased in terms of a confidential settlement agreement for a nominal value.

12.

WARRANTS

During the current year, warrants were issued to investors in conjunction with the Series "A" Preferred Stock. In addition, warrants were also issued to the placement agent in the Preferred Stock financing. See details of the equity financings above.

The fair value of these warrants is determined using the Black-Scholes model. The following weighted average assumptions were used:

	Year ended December 31, 2011			Year ended December 31, 2010

Risk-free interest rate	0.01% to 0.15		%	0.04% to 0.15		%
Expected life of the warrants	5 Years			5 Years
Expected volatility of the underlying stock		128	%		128	%
Expected dividend rate		0	%		0	%

A fair market value for these warrants of $115,385 was recorded as a deemed preferred stock dividend during the 2011 year. A further 15,000 warrants were issued to an individual for services rendered. These warrants were valued using the Back-Scholes model with the assumptions listed above and a $5,988 stock based compensation charge was recorded in the 2011 year.

At December 31, 2011, outstanding warrants to purchase shares of common stock are as follows:

Warrants	Exercise Price	Expiration Date

22,272	$5.70	March 2016
108,983	$5.70	April 2016
86,404	$5.70	May 2016
35,000	$5.70	June 2016
40,000	$5.70	July 2016
35,088	$5.70	September 2016
46,572	$5.70	October 2016
15,000	$2.00	October 2016

389,319

F-20

CALDERA PHARMACEUTICALS, INC.

NOTES TO THE CONSOLIDATED FINANCIAL STATEMENTS

13.	STOCK BASED COMPENSATION

In October 2005, the Company's Board of Directors adopted the Caldera Pharmaceuticals, Inc. 2005 Stock Option Plan (the "Plan"), which permits awards of incentive and nonqualified stock options and other forms of incentive compensation to employees and non-employees such as directors and consultants. The Board has 3, 000,000 shares of common stock for issuance upon exercise of grants made under the Plan. Options granted under the Plan vest either immediately or over a period of up to two years, and expire 4 years to 10 years from the grant date. At December 31, 2011, 2,481,555 shares were available for future grant under the Incentive Plan.

Stock option based compensation expense totaled $342,342 and $322,028 in 2011 and 2010, respectively. The Company expenses the value of stock options as earned. The fair value of the options granted is determined using the Black-Scholes option-pricing model. The following weighted average assumptions were used:

	Year ended December 31, 2011			Year ended December 31, 2010

Risk-free interest rate	0.01% to 0.15		%	0.04% to 0.15		%
Expected life of the options	5 Years			5 Years
Expected volatility of the underlying stock		128	%		128	%
Expected dividend rate		0	%		0	%

As noted above, the fair value of stock options is determined by using the Black-Scholes option-pricing model. For all options granted since October 1, 2005 the Company has generally used option terms of between 4 to 10 years, with 5 years representing the estimated life of options granted. The volatility of the common stock is estimated using historical data of companies similar in size and in the same industry as Caldera Pharmaceuticals. The risk-free interest rate used in the Black-Scholes option-pricing model is determined by reference to historical U.S. Treasury constant maturity rates with short-term maturities of no more than three months. An expected dividend yield of zero is used in the option valuation model, because the Company does not expect to pay any cash dividends in the foreseeable future. At December 31, 2011, the Company does not anticipate any awards will be forfeited in the calculation of compensation expense due to the limited number of employees that receive stock option grants.

During the year ended December 31, 2011, 9,555 options were exercised at an exercise price of $5.71 per share of common stock at a value of $54,559. No options were exercised for the 2010 period.

We canceled options exercisable for 235,000 and 57,188 shares of common stock in the years ended December 31, 2011 and 2010, respectively, held by employees whose service to our company terminated during those respective periods. The shares underlying such options were returned to and are available for re-issuance under the 2005 Plan pursuant to the terms described above.

F-21

CALDERA PHARMACEUTICALS, INC.

NOTES TO THE CONSOLIDATED FINANCIAL STATEMENTS

13.	STOCK BASED COMPENSATION (continued)

During the years ended December 31, 2011 and 2010, all awards granted under the Plan were incentive stock options. A summary of all of our option activity as of December 31, 2011 and 2010 and of changes in options outstanding under the plans during the year ended December 31, 2011 are as follows:

	Shares			Exercise price per share		Weighted average exercise price

Outstanding, January 1, 2010		277,688		$	2.00 - $5.71	$	4.77
Granted		65,000		$	5.71	$	5.71
Forfeited/Cancelled		(57,188	)	$	2.00 - $5.71	$	4.09
Exercised		-			-		-
Outstanding December 31, 2010		285,500		$	2.00 - $5.71	$	5.13
Granted		477,500		$	1.10 - $5.71	$	1.46
Forfeited/Cancelled		(235,000	)	$	1.10 - $5.71	$	1.16
Exercised		(9,555	)	$	5.71	$	5.71

Outstanding December 31, 2011		518,445		$	1.10 - $5.71	$	3.54

Stock options outstanding at December 31, 2011 and December 31, 2010, as disclosed in the above table, have $0 and $0 intrinsic value, respectively.

The following tables summarize information about stock options outstanding at December 31, 2011:

		Options Outstanding						Options Exercisable
Exercise Price		Number of shares		Weighted average remaining contractual years		Weighted Average Exercise Price		Number of Shares		Weighted Average exercise Price

$	1.10		220,000		9.17	$	1.10		220,000	$	1.10
$	2.00		30,000		3.92	$	2.00		30,000	$	2.00
$	5.71		268,445		6.70	$	5.71		228,570	$	5.71

			518,445		7.59	$	3.54		478,570	$	3.36

The weighted-average grant-date fair values of options granted during 2011 and 2010 were $0.43 and $4.84, respectively. As of December 31, 2011 there were unvested options to purchase 39,875 shares of common stock. Total expected unrecognized compensation cost related to such unvested options is $43,670, which is expected to be recognized over a weighted–average period of 6 months.

F-22

CALDERA PHARMACEUTICALS, INC.

NOTES TO THE CONSOLIDATED FINANCIAL STATEMENTS

14.	NET LOSS PER COMMON SHARE

Basic loss per share is based on the weighted-average number of common shares outstanding during each period. Diluted loss per share is based on basic shares as determined above plus the incremental shares that would be issued upon the assumed exercise of in-the-money stock options and warrants using the treasury stock method. The computation of diluted net loss per share does not assume the issuance of common shares that have an anti-dilutive effect on net loss per share. For the years ended December 31, 2011 and 2010, all stock options were excluded from the computation of diluted net loss per share. Dilutive shares which could exist pursuant to the exercise of outstanding stock instruments and which were not included in the calculation because their affect would have been anti-dilutive are as follows:

	Year ended December 31, 2011 (Shares)		Year ended December 31, 2010 (Shares)

Options to purchase shares of common stock		518,445		285,500
Series “A” Convertible Preferred stock		331,519		-
Warrants		389,319		-

		1,239,283		285,500

15.	RELATED PARTY TRANSACTIONS

The majority of the shares in the Company are owned by Benjamin Warner, the Chief Executive Officer. As at December 31, 2011 and 2010 respectively, Benjamin Warner owned 74.3% and 65.7% respectively.

Loans from related parties

	December 31, 2011		December 31, 2010
Short term loans
Benjamin P Warner	$	-	$	77,600

	$	-	$	77,600

The loan from Benjamin Warner is interest free and has no fixed repayment terms. Subsequent to year-end, the balance outstanding on the loan was converted to units consisting of Preferred stock and warrants.

F-23

CALDERA PHARMACEUTICALS, INC.

NOTES TO THE CONSOLIDATED FINANCIAL STATEMENTS

16.	OPERATING LEASES

The Company extended its existing office lease effective November 1, 2010. The monthly rent amounts to $4,928 per month and the lease terminates in October 2013.

The Company entered into an office sub-lease agreement with Greg Rzepczynski & Associates, LTD effective September1, 2011. The monthly rent amounts to $4,000 per month and the lease expires in September 2012.

Future annual minimum payments required under operating lease obligations at December 31, 2011, are as follows:

	Amount

2012		95,426
2013		50,753
Total	$	146,179

17.	LITIGATION

Los Alamos National Security Suit

F-24

CALDERA PHARMACEUTICALS, INC.

NOTES TO THE CONSOLIDATED FINANCIAL STATEMENTS

17.	LITIGATION (continued)

Seddie Bastanipour and Joel Bellows Suit

In December 2010, the Company filed suit against Seddie Bastanipour and Peter Baltrus for breach of contract and negligence when they were performing accounting services on behalf of the Company which resulted in an IRS penalty. In December 2011, the Company completed an amicable settlement with Bastanipour that is subject to confidentiality restraints and she is no longer party to either suit. The settlement did not have a material impact on our financial position. Baltrus claims to have been working for Bellows (see above) at all relevant times; the case against Peter Baltrus continues. The Company has entered into further settlement discussions with Peter Baltrus and has an April 30, 2012 response date to a full discovery request by Mr. Baltrus.

No accrual has been made for this matter because it is not probable that a loss has been incurred and we are unable to estimate what the outcome of the matter would be.

18.	SUBSEQUENT EVENTS

Series “A” 8% Convertible Preferred Stock and Common Stock Purchase Warrants

Subsequent to year end and in terms of a private placement memorandum dated June 24, 2011, a further 10,088 units of series “A” convertible preferred stock (“Preferred Stock”) and common stock purchase warrants were issued to Series “A” preferred stockholders at a par value of $0.001 per share for a total consideration of $57,500.

Other than disclosed above, the Company has evaluated subsequent events through the date the financial statements were issued, and has concluded that no such events or transactions took place that would require disclosure herein.

F-25

Table of Contents

PA RT II

INFORMATION NOT REQUIRED IN PROSPECTUS

Item 13. Other Expenses of Issuance and Distribution.

We estimate that expenses in connection with the distribution described in this registration statement (other than brokerage commissions, discounts or other expenses relating to the sale of the shares by the selling security holders) will be as set forth below. We will pay all of the expenses with respect to the distribution, and such amounts, with the exception of the Securities and Exchange Commission (“SEC”) registration fee, are estimates.

SEC registration fee	$	806.48
Accounting fees and expenses		10,000
Legal fees and expenses	$	25,000
Printing and related expenses	$	5,000
Transfer agent fees and expenses		2,000
Miscellaneous		2,193.52
Total	$	45,000

Item 14. Indemnification of Directors and Officers.

·	diluting the voting or other rights of the proposed acquirer or insurgent stockholder group;

·	putting a substantial voting block in institutional or other hands that might undertake to support the incumbent board of directors; or

·	effecting an acquisition that might complicate or preclude the takeover.

We may also purchase and maintain insurance for the benefit of any director or officer that may cover claims for which we could not indemnify such person.

II-1

Table of Contents

Item 15. Recent Sales and Issuances of Unregistered Securities.

In April 2009 we issued options to one individual (the “April 2009 Options”) for services rendered exercisable for a period of ten years for 50,000 shares of common stock and in October 2009 we issued options (the “October 2009 Options”) to one individual for services rendered exercisable for ten years for 20,000 shares of common stock. The exercise price of both issuances was $5.71 per share. The options vested 50% after one year and 12.5% quarterly thereafter, with all options vesting in 2011. The issuance of the options qualified for exemption under Section 4(2) of the Securities Act since the issuance by the Company did not involve a public offering. The issuance was not a public offering as defined in Section 4(2) because the offer and sale was made to an insubstantial number of persons and because of the manner of the offering. In addition, the investors had the necessary investment intent as required by Section 4(2) since they agreed to, and received, certificates bearing a legend stating that such options and the underlying shares are restricted. This restriction ensured that these securities will not be immediately redistributed into the market and therefore be part of a public offering. This issuance was done with no general solicitation or advertising by the Company. Based on an analysis of the above factors, the Company met the requirements to qualify for exemption under Section 4(2) of the Securities Act for the transactions.

In January 2010 we issued options to two individuals (the “January 2010 Options”) for services rendered exercisable for a period of ten years for an aggregate of 40,000 shares of common stock and in July 2010 we issued options ( the “July 2010 Options”) to two individuals for services rendered exercisable for ten years for an aggregate of 25,000 shares of common stock. The exercise price of both issuances was $5.71 per share. The options vested 50% after one year and 12.5% quarterly thereafter, with all of the January 2010 Options being fully vested and the July 2010 Options being fully vested in July 2012. The issuance of the options qualified for exemption under Section 4(2) of the Securities Act since the issuance by the Company did not involve a public offering. The issuance was not a public offering as defined in Section 4(2) because the offer and sale was made to an insubstantial number of persons and because of the manner of the offering. In addition, the investors had the necessary investment intent as required by Section 4(2) since they agreed to, and received, certificates bearing a legend stating that such options and underlying shares are restricted. This restriction ensured that these securities will not be immediately redistributed into the market and therefore be part of a public offering. This issuance was done with no general solicitation or advertising by the Company. Based on an analysis of the above factors, the Company met the requirements to qualify for exemption under Section 4(2) of the Securities Act for the transactions.

On October 26, 2010 we issued 324,500 shares of common stock to three related parties in consideration of $178,475 of consulting services rendered by a third party. The issuance of the shares of common stock qualified for exemption under Section 4(2) of the Securities Act since the issuance by the Company did not involve a public offering. The issuance was not a public offering as defined in Section 4(2) because the offer and sale was made to an insubstantial number of persons and because of the manner of the offering. In addition, the investors had the necessary investment intent as required by Section 4(2) since they agreed to, and received, share certificates bearing a legend stating that such shares are restricted. This restriction ensured that these shares will not be immediately redistributed into the market and therefore be part of a public offering. This issuance was done with no general solicitation or advertising by the Company. Based on an analysis of the above factors, the Company met the requirements to qualify for exemption under Section 4(2) of the Securities Act for the transactions.

In February 2011 we issued options to three individuals for 460,000 shares of common stock exercisable for a period of ten years. The exercise price of options exercisable for 20,000 shares of common stock was $5.71 per share and the exercise price of options exercisable for 440,000 shares of common stock was $1.10 per share. The options exercisable for 20,000 shares of common stock vested 50% after one year and 12.5% quarterly thereafter, with all of such options being fully vested February 2013 and the 440,000 options vested immediately subject to forfeiture. Options exercisable for 220,000 shares of common stock expired. The issuance of the options qualified for exemption under Section 4(2) of the Securities Act since the issuance by the Company did not involve a public offering. The issuance was not a public offering as defined in Section 4(2) because the issuance was made to an insubstantial number of persons and because of the manner of the offering. In addition, the investors had the necessary investment intent as required by Section 4(2) since they agreed to, and received, certificates bearing a legend stating that such options and the underlying shares are restricted. This restriction ensured that these securities will not be immediately redistributed into the market and therefore be part of a public offering. This issuance was done with no general solicitation or advertising by the Company. Based on an analysis of the above factors, the Company met the requirements to qualify for exemption under Section 4(2) of the Securities Act for the transactions.

II-2

Table of Contents

In May 2011 we issued options to two individuals for services rendered exercisable for a period of ten years for an aggregate of 12,500 shares of common stock. The exercise price of both issuances was $5.71 per share. Of such options, 12,000 vested on a monthly basis of 1,000 options per month and 500 vested 50% after one year and 12.5% quarterly thereafter, with all of the January 2010 Options being fully vested and the July 2010 Options being fully vested in July 2012. The issuance of the options qualified for exemption under Section 4(2) of the Securities Act since the issuance by the Company did not involve a public offering. The issuance was not a public offering as defined in Section 4(2) because the issuance was made to an insubstantial number of persons and because of the manner of the offering. In addition, the investors had the necessary investment intent as required by Section 4(2) since they agreed to, and received, certificates bearing a legend stating that such options and underlying shares are restricted. This restriction ensured that these securities will not be immediately redistributed into the market and therefore be part of a public offering. This issuance was done with no general solicitation or advertising by the Company. Based on an analysis of the above factors, the Company met the requirements to qualify for exemption under Section 4(2) of the Securities Act for the transactions.

On October 22, 2010, the Company issued 90,000 shares to two existing shareholders in exchange for their judgment and settlement agreement obtained against the third shareholder. The issuance of the shares of common stock qualified for exemption under Section 4(2) of the Securities Act since the issuance by the Company did not involve a public offering. The issuance was not a public offering as defined in Section 4(2) because the offer and sale was made to an insubstantial number of persons and because of the manner of the offering. In addition, the investors had the necessary investment intent as required by Section 4(2) since they agreed to, and received, share certificates bearing a legend stating that such shares are restricted. This restriction ensured that these shares will not be immediately redistributed into the market and therefore be part of a public offering. This issuance was done with no general solicitation or advertising by the Company. Based on an analysis of the above factors, the Company met the requirements to qualify for exemption under Section 4(2) of the Securities Act for the transactions.

From March 2011 through January 2012, the Company raised $1,804,450 from the sale of securities to 19 investors in a private placement in which it sold units at a price of $5.70 per share for an aggregate of 316,572 shares of series A convertible preferred stock (“Preferred Stock”) and five-year warrants to purchase shares of the Company’s common stock equal to 100% of the number of shares that they would receive upon conversion of the Preferred Stock into common stock. In connection with the private placement, the Company issued warrants exercisable for an aggregate of 42,800 shares of common stock to two different placement agents. The offering and sale of the shares of the securities qualified for exemption under Section 4(2) of the Securities Act and Regulation D promulgated thereunder since the issuance by the Company did not involve a public offering. The offering was not a public offering as defined in Section 4(2) because the offer and sale was made to an insubstantial number of persons and because of the manner of the offering. In addition, the investors had the necessary investment intent as required by Section 4(2) since they agreed to, and received, certificates bearing a legend stating that such securities are restricted. This restriction ensured that these securities will not be immediately redistributed into the market and therefore be part of a public offering. This offering was done with no general solicitation or advertising by the Company. Based on an analysis of the above factors, the Company met the requirements to qualify for exemption under Section 4(2) of the Securities Act for the transactions.

In April 2011 we issued 25,035 shares of Series A Preferred Stock and a warrant exercisable for 25,035 shares of common stock to our Chief Executive Officer in lieu of repayment of loans totaling $142,700 that he and entities controlled by him had made to the Company. The issuance of the securities qualified for exemption under Section 4(2) of the Securities Act and Regulation D promulgated thereunder since the issuance by the Company did not involve a public offering. The issuance was not a public offering as defined in Section 4(2) because the offer and sale was made to an insubstantial number of persons and because of the manner of the offering. In addition, the investor had the necessary investment intent as required by Section 4(2) since the investor agreed to, and received, share certificates and warrant certificates bearing a legend stating that such shares are restricted. This restriction ensured that these securities will not be immediately redistributed into the market and therefore be part of a public offering. This offering was done with no general solicitation or advertising by the Company. Based on an analysis of the above factors, the Company met the requirements to qualify for exemption under Section 4(2) of the Securities Act for the transactions.

On October 31, 2011, the Company issued five-year warrants exercisable for 15,000 shares of common stock to a consultant for services performed. The warrants are exercisable at a price of $2.00 per share. The issuance of the warrants qualified for exemption under Section 4(2) of the Securities Act since the issuance by the Company did not involve a public offering. The issuance was not a public offering as defined in Section 4(2) because the offer and sale was made to an insubstantial number of persons and because of the manner of the offering. In addition, the investors had the necessary investment intent as required by Section 4(2) since they agreed to, and received, certificates bearing a legend stating that such warrants and the underlying shares are restricted. This restriction ensured that these securities will not be immediately redistributed into the market and therefore be part of a public offering. This issuance was done with no general solicitation or advertising by the Company. Based on an analysis of the above factors, the Company met the requirements to qualify for exemption under Section 4(2) of the Securities Act for the transactions.

From March 2011 through May 2011 we issued 2,459 shares of common stock to one individual upon exercise of the April 2009 Options, 2,212 shares of common stock to another individual upon exercise of the October 2009 Options, 1,830 shares of common stock to another individual upon exercise of the January 2010 Options, 2,418 shares of common stock to another individual upon exercise of the January 2010 Options and 636 shares of common stock to another individual upon exercise of the July 2010 Options. The issuances of common stock were exempt from registration under Section 3(a)(9) of the Securities Act.

II-3

Table of Contents

In August and September 2011 we issued options to five individuals for services rendered exercisable for a period of ten years for an aggregate of 5,000 shares of common stock. The exercise price of both issuances was $5.71 per share. The options vested 50% after one year and 12.5% quarterly thereafter, with all of the August options being fully vested in August 2013 and all of the September options being fully vested in September 2013. The issuance of the options qualified for exemption under Section 4(2) of the Securities Act since the issuance by the Company did not involve a public offering. The issuance was not a public offering as defined in Section 4(2) because the offer and sale was made to an insubstantial number of persons and because of the manner of the offering. In addition, the investors had the necessary investment intent as required by Section 4(2) since they agreed to, and received, certificates bearing a legend stating that such options and the underlying shares are restricted. This restriction ensured that these securities will not be immediately redistributed into the market and therefore be part of a public offering. This issuance was done with no general solicitation or advertising by the Company. Based on an analysis of the above factors, the Company met the requirements to qualify for exemption under Section 4(2) of the Securities Act for the transactions.

In each of December 2011 and February 2012, we issued 50,000 shares of common stock to one entity in consideration of services rendered. The issuance of the shares of common stock qualified for exemption under Section 4(2) of the Securities Act since the issuance by the Company did not involve a public offering. The issuance was not a public offering as defined in Section 4(2) because the offer and sale was made to an insubstantial number of persons and because of the manner of the offering. In addition, the investors had the necessary investment intent as required by Section 4(2) since they agreed to, and received, share certificates bearing a legend stating that such shares are restricted. This restriction ensured that these shares will not be immediately redistributed into the market and therefore be part of a public offering. This issuance was done with no general solicitation or advertising by the Company. Based on an analysis of the above factors, the Company met the requirements to qualify for exemption under Section 4(2) of the Securities Act for the transactions.

In February 2012, we issued 10,650 shares of common stock to 13 investors as a dividend with respect to the Series A preferred shares they hold. The issuance of the shares of common stock qualified for exemption under Section 4(2) of the Securities Act since the issuance by the Company did not involve a public offering. The issuance was not a public offering as defined in Section 4(2) because the offer and sale was made to an insubstantial number of persons and because of the manner of the offering. In addition, the investors had the necessary investment intent as required by Section 4(2) since they agreed to, and received, share certificates bearing a legend stating that such shares are restricted. This restriction ensured that these shares will not be immediately redistributed into the market and therefore be part of a public offering. This issuance was done with no general solicitation or advertising by the Company. Based on an analysis of the above factors, the Company met the requirements to qualify for exemption under Section 4(2) of the Securities Act for the transactions.

Item 16. Exhibits.

Exhibit No.	Description

3.1	Certificate of Incorporation dated November 12, 2003*
3.2	First Amended and Restated Certificate of Incorporation dated March 8, 2011*
3.3	Certificate of Designations dated March 14, 2011*
3.4	By-Laws*
3.5	Second Amended and Restated Certificate of Incorporation dated April 10, 2012**
4.1	Form of Warrant to Purchase Common Stock*
4.2	Promissory Note, dated September 21, 2006, in the principal amount of $2,200,000 payable to the Incorporated County of Los Alamos*
4.3	Stock Option Plan*
4.4	List of Warrant Holders*
5.1	Opinion of Gracin & Marlow, LLP
10.1	Employment Agreement with Dr. Benjamin Warner* *
10.2	Employment Agreement with Lori Peterson (nee Court) *
10.3	Exclusive Patent License Agreement, dated September 8, 2005, by and between the Company and The Regents of the University of California*
10.4	Project Participation Agreement, dated as of September 21, 2006, by and between the Company and the Incorporated County of Los Alamos*
10.5	Amendment No. 1 to Participation Agreement, dated as of February 21, 2007, by and between the Company and the Incorporated County of Los Alamos*
10.6	OEM Agreement, dated July 5, 2011, by and between the Company and Bruker Nano GmbH*
10.7	Assignment of Exclusive License Agreement by The Regents of the University of California to Los Alamos National Security, LLC**
10.8	Lease Agreement with Reeves & Associates, LLC in connection with Suite C**
10.9	Lease Agreement with Reeves & Associates, LLC in connection with Suite D**
10.10	Extension and Modification of Lease Agreements**
10.11	2005 Option Plan*
10.12	Contract 2R44AI079935-03 with the National Institutes of Health; to develop strontium-selective therapies, contract amount: $3,000,000.00, operative from 08/24/2011 - 07/31/2014, $184,954.01. Contract 1R43GM090387-01 with the National Institutes of Health; to develop assays for carcinogens, contract amount: $200,000.00, operative from 08/06/2010 - 08/05/2012.
21.1	List of subsidiaries*
23.1	Consent of Registered Public Accounting Firm*
23.2	Consent of Gracin & Marlow, LLP (included in Exhibit 5.1)*

* Previously Filed

** Filed herewith

II-4

Table of Contents

Item 17. Undertakings

A. Rule 415 Offering

The undersigned registrant hereby undertakes:

(1) To file, during any period in which offers or sales are being made, a post-effective amendment to this registration statement:

(i) To include any prospectus required by Section 10(a)(3) of the Securities Act of 1933;

(ii) To reflect in the prospectus any facts or events arising after the effective date of the registration statement (or the most recent post-effective amendment thereof) which, individually or in the aggregate, represent a fundamental change in the information set forth in the registration statement. Notwithstanding the foregoing, any increase or decrease in volume of securities offered (if the total dollar value of securities offered would not exceed that which was registered) and any deviation from the low or high end of the estimated maximum offering range may be reflected in the form of prospectus filed with the Commission pursuant to Rule 424(b) if, in the aggregate, the changes in volume and price represent no more than 20 percent change in the maximum aggregate offering price set forth in the “Calculation of Registration Fee” table in the effective registration statement.

(iii) To include any material information with respect to the plan of distribution not previously disclosed on the registration statement or any material change to such information in the registration statement;

(2) That, for the purpose of determining any liability under the Securities Act of 1933 , each such post-effective amendment shall be deemed to be a new registration statement relating to the securities offered therein, and the offering of such securities at that time shall be deemed to be the initial bona fide offering thereof.

(3) To remove from registration by means of a post-effective amendment any of the securities being registered which remain unsold at the termination of the offering.

(4) That, for the purpose of determining liability under the Securities Act of 1933 to any purchaser in the initial distribution of the securities:

The undersigned registrant undertakes that in a primary offering of the securities of the undersigned registrant pursuant to this registration statement, regardless of the underwriting method used to sell the securities to the purchaser, if the securities are offered or sold to such purchaser by means of any of the following communications, the undersigned registrant will be a seller and will be considered to offer or sell such securities to such purchaser:

(i) Any preliminary prospectus or prospectus of the undersigned registrant relating to the offering required to be filed pursuant to Rule 424 (§230.424 of this chapter);

(ii) Any free writing prospectus relating to the offering prepared by or on behalf of the undersigned registrant or used or referred to by the undersigned registrant;

(iii) The portion of any other free writing prospectus relating to the offering containing material information about the undersigned registrant or its securities provided by or on behalf of the undersigned registrant; and

(iv) Any other communication that is an offer in the offering made by the undersigned registrant to the purchaser.

B. Request for Acceleration of Effective Date

Insofar as indemnification for liabilities arising under the Securities Act may be permitted to directors, officers and controlling persons of the Company pursuant to the foregoing provisions, or otherwise, the Company has been advised that in the opinion of the Securities and Exchange Commission such indemnification is against public policy as expressed in the Securities Act and is, therefore, unenforceable. In the event that a claim for indemnification against such liabilities (other than the payment by the Company of expenses incurred or paid by a director, officer or controlling person of the Company in the successful defense of any action, suit or proceeding) is asserted by such director, officer or controlling person in connection with the securities being registered, the Company will, unless in the opinion of its counsel the matter has been settled by controlling precedent, submit to a court of appropriate jurisdiction the question whether such indemnification by it is against public policy as expressed in the Securities Act and will be governed by the final adjudication of such issue.

II-5

Table of Contents

SIGNATURES

Pursuant to the requirements of the Securities Act of 1933, the registrant has duly authorized this registration statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the city of Los Alamos, New Mexico, on April 20 , 2012.

CALDERA PHARMACEUTICALS, INC.

By:	/s/ Dr. Benjamin Warner
	Dr. Benjamin Warner, Chief Executive Officer , Chief Financial Officer and Director

Pursuant to the requirements of the Securities Act of 1933, this registration statement has been signed by the following persons in the capacities and on the dates indicated.

Signature	Title	Date

/s/ Dr. Benjamin Warner	Chief Executive Officer and Director	April 20 , 2012
Dr. Benjamin Warner	(Principal Executive Officer and Principal Financial Officer )

/s/ Jeremiel Zimmerman	Director	April 20 , 2012
Jeremiel Zimmerman

/s/ Edward Roffman		Director		April 20 , 2012
Edward Roffman

II-6

Delaware		3826		20-0982060
(State or jurisdiction of incorporation or organization)		(Primary Standard Industrial Classification Code Number)		(I.R.S. Employer Identification No.)

Large accelerated filer	o	Accelerated filer	o
Non-accelerated filer	o	Smaller reporting company	x
(Do not check if a smaller reporting company)

Title of Each Class of Securities to be Registered	Amount to be Registered (1)		Proposed Maximum Offering Price Per Share (2)		Proposed Maximum Aggregate Offering Price		Amount of Registration Fee (3) (4)
Shares of common stock, par value $0.001		774,325	$	$5.00	$	3,8 71,625	$	443.69
Shares of common stock, par value $0.001 to be issued upon the exercise of outstanding warrants and convertible preferred stock		633,144	$	$5.00	$	3,165,750	$	362.79
Total shares being registered		1, 407,469			$	7,037,345	$	806.48


Shares of our common stock offered for re-sale by the selling stockholders pursuant to this prospectus		1 ,407,469

Common stock currently outstanding		4, 302,270

Proceeds to the Company		We will not receive any proceeds from the resale or other disposition of the shares covered by this prospectus by any selling shareholder. We will receive net proceeds from the exercise of the warrants to purchase shares of our common stock covered by this prospectus which would total $ 2,221,119 if all the warrants were exercised for cash payment.

Risk Factors		There are significant risks involved in investing in our Company. For a discussion of risk factors you should consider before buying our common stock see “Risk Factors” beginning on page 3

/s/ Philip Kunsberg		10/28/10
Philip Kunsberg		Date


/s/ Benjamin Warner		10/27/10
Benjamin Warner, President		Date
Caldera Pharmaceuticals, Inc.

	Pa ge
PROSPECTUS SUMMARY	1

RISK FACTORS	3

USE OF PROCEEDS	12

BUSINESS	12

DETERMINATION OF OFFERING PRICE	18

DILUTION	18

MANAGEMENT’S DISCUSSION AND ANALYSIS OR PLAN OF OPERATION	1 9

DIRECTORS, EXECUTIVE OFFICERS, PROMOTERS AND CONTROL PERSONS	23

EXECUTIVE COMPENSATION	24

SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENT	26

SELLING STOCKHOLDERS	27

PLAN OF DISTRIBUTION	30

CERTAIN RELATIONSHIPS AND RELATED TRANSACTIONS	31

DESCRIPTION OF SECURITIES	31

EXPERTS	33

DISCLOSURE OF COMMISSION POSITION ON INDEMNIFICATION FOR SECURITIES ACT LIABILITIES	33

LEGAL MATTERS	33

WHERE YOU CAN FIND MORE INFORMATION	34

PART II	II-1

Caldera Pharmaceuticals, Inc.	Employee
Print Name:	Print Name: Benjamin Warner
[Signed]	[Signed] /Benjamin Warner/
Date	Date

	Notice of Award
	SMALL BUSINESS INNOVATION RESEARCH PROG Department of Health and Human Services National Institutes of Health NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES	Issue Date: 08/23/2011

Award Calculation (U.S. Dollars)
Salaries and Wages	$	122,616
Fringe Benefits	$	35,780
Supplies	$	179,000
Travel Costs	$	1,000
Consortium/Contractual Cost	$	329,200

Federal Direct Costs	$	667,596
Federal F&A Costs	$	267,038
Approved Budget	$	934,634
Fee	$	65,366
Federal Share	$	1,000,000
TOTAL FEDERAL AWARD AMOUNT	$	1,000,000

AMOUNT OF THIS ACTION (FEDERAL SHARE)	$	1,000,000

SUMMARY TOTALS FOR ALL YEARS
YR	THIS AWARD		CUMULATIVE TOTALS
3	$	1,000,000		$	1,000,000
4	$	1,000,000		$	1,000,000
5	$	1,000,000		$	1,000,000

CFDA Number:	93.855
EIN:	1200982060A1
Document Number:	RAI079935B
Fiscal Year:	2011

Budget	Year 3		Year 4		Year 5
Salaries and Wages	$	122,616	$	73,962	$	49,414
Fringe Benefits	$	35,780	$	21,582	$	14,419

Supplies	$	179,000	$	163,200	$	153,000
Travel Costs	$	1,000	$	1,000	$	1,000
Consortium/Contractual Cost	$	329,200	$	407,900	$	450,000
FEE	$	65,366	$	65,298	$	65,034
TOTAL FEDERAL DC	$	667,596	$	667,644	$	667,833
TOTAL FEDERAL F&A	$	267,038	$	267,058	$	267,133
TOTAL COST	$	1,000,000	$	1,000,000	$	1,000,000

Facilities and Administrative Costs	Year 3			Year 4			Year 5
F&A Cost Rate 1		40	%		40	%		40	%
F&A Cost Base 1	$	667,596		$	667,644		$	667,833
F&A Costs 1	$	267,038		$	267,058		$	267,133

	Notice of Award
	SMALL BUSINESS INNOVATION RESEARCH PROG Department of Health and Human Services National Institutes of Health NATIONAL CANCER INSTITUTE	Issue Date: 08/06/2010

●	Report on the inclusion of gender and minority study subjects (using the gender and minority Inclusion Enrollment Form as provided in the PHS 2590 and available at http://grants.nih.qov/grantsfforms.htm).
●	Where appropriate, indicate whether children were involved in the study or how the study was relevant for conditions affecting children (see "Public Policy Requirements and Objectives-Requirements for Inclusiveness in Research Design-Inclusion of Children as Subjects in Clinical Research" in the PHS 398 at URL http://grants.nih.gov/grants/policy/nihops_2003/NIHGPS_Part5.htm#_Toc54600090)
●	Describe any data, research materials (such as cell lines, DNA probes, animal models), protocols, software, or other information resulting from the research that is available to be shared with other investigators and how it may be accessed.

Budget	Year 1
Salaries and Wages	$	58,142
Fringe Benefits	$	16,966
Supplies	$	30,000
Travel Costs	$	2,000
Other Costs	$	3,000
FEE	$	12,519
TOTAL FEDERAL DC	$	110,108
TOTAL FEDERAL F&A	$	77,373
TOTAL COST	$	200,000

Facilities and Administrative Costs	Year 1
F&A Cost Rate 1		70.27	%
F&A Cost Base 1	$	110,108
F&A Costs 1	$	77,373