Exhibit 99.1

Soligenix Announces Investor Webcast Event and Presentation Today:

Advantages of the CiVax™ Program for Development of a Broadly Distributed Heat Stable COVID-19 Vaccine

Preclinical data supports potential for:

Princeton, NJ – September 10, 2020 – Soligenix, Inc. (Nasdaq: SNGX) (Soligenix or the Company), a late-stage biopharmaceutical company focused on developing and commercializing products to treat rare diseases where there is an unmet medical need, released the presentation for its Investor Webcast event today from 4:00 – 5:00 pm Eastern Time on the use of its thermostabilized glycoprotein vaccine platform for the development of a COVID-19 vaccine, called CiVax™.

The development of CiVax™ is based on the thermostabilized glycoprotein vaccine platform which Soligenix has been developing in collaboration with the University of Hawaiʻi at Mānoa, focused on multivalent thermostabilized vaccines for filovirus infections such as Ebola.

The vaccine platform includes three essential components:

The resulting vaccine is broadly applicable, including to individuals often excluded from common viral vector vaccine approaches such as children, the elderly and the immunocompromised. These same components can now be applied to a COVID-19 vaccine, using well-defined surface glycoprotein(s) from one or more coronaviruses. The protection of elderly and immunocompromised populations are particularly important in the context of COVID-19.

Data with a prototype vaccine has confirmed the potential to elicit both strong cell mediated immunity as well as a balanced humoral (antibody) responses. Very strong neutralizing antibody responses, similar to those found in convalescent plasma, have also been shown in mice. These results have been released in a pre-print article available here. More recent studies have demonstrated that when utilizing a more complete Spike protein antigen (as intended in the final CiVax™ formulation) strong antibody responses are evident as soon as 7 days after the first vaccination, with rapid boosting as soon as 7 days after the second vaccination. At the same time, antibody responses and cell mediated immune responses have both demonstrated the desired Th1 bias.

Conference Call Thursday, September 10 at 4:00 PM Eastern Time

The Company will share information on its thermostabilized glycoprotein vaccine platform for the development of a COVID-19 vaccine on Thursday, September 10, 2020 during a webcast event. A question and answer (Q&A) session with the featured experts and management will follow the presentations. If you would like to ask a question during the Q&A, please submit your request via email to ir@soligenix.com at least 15 minutes prior to the scheduled start of the call.

Live Event: https://www.webcaster4.com/Webcast/Page/2498/37323

U.S. toll free:    1-866-652-5200

International:    1-412-317-6060

Please request to be entered into the Soligenix call.

An audio recording and transcript of the presentation will be archived for 30 days following the event.

The Investor Event will include presentations from the following:

Dr. Axel Lehrer, Associate Professor, Department. of Tropical Medicine, Medical Microbiology and Pharmacology, University of Hawaiʻi at Mānoa, John A. Burns School of Medicine

Dr. Oreola Donini, Chief Scientific Officer of Soligenix

Mr. Dan Ring, Vice President, Business Development of Soligenix

Dr. Christopher J Schaber, President and Chief Executive Officer of Soligenix

Featured Expert Biographical Background

Axel Lehrer, PhD

Axel Lehrer, Dr. rer. nat., Associate Professor, Department of Tropical Medicine, Medical Microbiology and Pharmacology, John A. Burns School of Medicine, University of Hawaiʻi at Mānoa. Dr. Lehrer has been researching vaccines since 2002 in both commercial and academic settings. He has primarily worked on developing vaccines for filoviruses such as Ebola virus, but also contributed to the development of flavivirus vaccines (Zika virus, Tick-borne encephalitis (TBE) virus, West Nile virus and Dengue virus). His research mostly employs recombinant viral subunits expressed and purified from an insect cell expression system. Dr. Lehrer’s is trained in biochemistry, molecular biology, virology, as well as immunology and his research has received funding from NIH and other federal sources.

About CiVax™

CiVax™ is the Company's heat stable subunit vaccine candidate for the prevention of COVID-19, the infection caused by SARS-CoV-2. Under the Company's Public Health Solutions business segment, ongoing collaborations with Axel Lehrer, PhD of the Department of Tropical Medicine, Medical Microbiology and Pharmacology, JABSOM, UHM have demonstrated the feasibility of developing heat stable subunit filovirus vaccines, including hemorrhagic disease caused by Zaire ebolavirus, Sudan ebolavirus as well as Marburg marburgvirus, with both monovalent and bivalent vaccine combinations. Formulation conditions have been identified to enable heat stabilization of each antigen, alone or in combination, for at least 12 weeks at 40 degrees Celsius (104 degrees Fahrenheit). In March 2020, Soligenix and its collaborators expanded the technology platform to assess compatibility with vaccine candidates targeting SARS-CoV-2, the cause of COVID-19.

The vaccine platform includes three essential components:

The resulting vaccine is broadly applicable, including to individuals often excluded from common viral vector vaccine approaches such as children, the elderly and the immunocompromised. The protection of elderly and immunocompromised populations are particularly important in the context of COVID-19. The ability to provide a thermostabilized, single vial vaccine, is particularly important in the context of rapid and broad vaccine distribution.

These same components are now being applied to coronavirus vaccine, using the well-defined surface glycoprotein, known as the Spike protein, as the antigen. Pre-clinical work in mice with a prototype vaccine recently have been made available, demonstrating the ability of the CoVaccine adjuvant in combination with a prototype antigen, to:

Recently, pre-clinical studies with a more complete Spike protein (as intended in the final formulation) have demonstrated all the same attributes, including a rapid onset of immunogenicity within 7 days of the first vaccination.

About Coronavirus Infection

Coronavirus infections can cause a wide spectrum of disease in humans, ranging from a common cold to a more severe respiratory infection, such as Severe Acute Respiratory Syndrome (SARS) and Middle East Respiratory Syndrome (MERS), which have a case mortality rate of approximately 10% and 30%, respectively. Similar to filoviruses, coronaviruses also are endemic in wildlife populations and can be transmitted to humans with close contact. The COVID-19 outbreak, caused by SARS-CoV-2, is the most recent example of a suspected species crossover seen with this virus family. Although the case fatality rate of COVID-19 is still under investigation, COVID-19 has been declared a global pandemic by the World Health Organization. The global impact of this emerging infection demonstrates the urgent need for robust technology platforms to rapidly develop new vaccines for novel diseases. The only FDA sanctioned treatments for COVID-19 are available under "Emergency Use Authorization." There is currently no approved vaccine.

About Soligenix, Inc.

Soligenix is a late-stage biopharmaceutical company focused on developing and commercializing products to treat rare diseases where there is an unmet medical need. Our Specialized BioTherapeutics business segment is developing SGX301 as a novel photodynamic therapy utilizing safe visible light for the treatment of cutaneous T-cell lymphoma; our first-in-class innate defense regulator (IDR) technology, dusquetide (SGX942), for the treatment of oral mucositis in head and neck cancer; and proprietary formulations of oral beclomethasone 17,21-dipropionate (BDP) for the prevention/treatment of gastrointestinal (GI) disorders characterized by severe inflammation including pediatric Crohn's disease (SGX203) and acute radiation enteritis (SGX201).

Our Public Health Solutions business segment includes active development programs for RiVax^®, our ricin toxin vaccine candidate; SGX943, our therapeutic candidate for antibiotic resistant and emerging infectious disease; and our research programs to identify and develop novel vaccine candidates targeting viral infection including Ebola, Marburg and SARS-CoV-2 (the cause of COVID-19). The development of our vaccine programs incorporates the use of our proprietary heat stabilization platform technology, known as ThermoVax^®. To date, this business segment has been supported with government grant and contract funding from the National Institute of Allergy and Infectious Diseases (NIAID), the Defense Threat Reduction Agents (DTRA) and the Biomedical Advanced Research and Development Authority (BARDA). 

For further information regarding Soligenix, Inc., please visit the Company's website at www.soligenix.com.

This press release may contain forward-looking statements that reflect Soligenix, Inc.'s current expectations about its future results, performance, prospects and opportunities, including but not limited to, potential market sizes, patient populations and clinical trial enrollment. Statements that are not historical facts, such as "anticipates," "estimates," "believes," "hopes," "intends," "plans," "expects," "goal," "may," "suggest," "will," "potential," or similar expressions, are forward-looking statements. These statements are subject to a number of risks, uncertainties and other factors that could cause actual events or results in future periods to differ materially from what is expressed in, or implied by, these statements, such as experienced with the COVID-19 outbreak. Soligenix cannot assure you that it will be able to successfully develop, achieve regulatory approval for or commercialize products based on its technologies, particularly in light of the significant uncertainty inherent in developing therapeutics and vaccines against bioterror threats, conducting preclinical and clinical trials of therapeutics and vaccines, obtaining regulatory approvals and manufacturing therapeutics and vaccines, that product development and commercialization efforts will not be reduced or discontinued due to difficulties or delays in clinical trials or due to lack of progress or positive results from research and development efforts, that it will be able to successfully obtain any further funding to support product development and commercialization efforts, including grants and awards, maintain its existing grants which are subject to performance requirements, enter into any biodefense procurement contracts with the US Government or other countries, that it will be able to compete with larger and better financed competitors in the biotechnology industry, that changes in health care practice, third party reimbursement limitations and Federal and/or state health care reform initiatives will not negatively affect its business, or that the US Congress may not pass any legislation that would provide additional funding for the Project BioShield program. In addition, there can be no assurance as to the timing or success of the Phase 3 clinical trial of SGX942 (dusquetide) as a treatment for oral mucositis in patients with head and neck cancer receiving chemoradiation therapy, or any of our other clinical/preclinical trials. Despite the statistically significant result achieved in the SGX301 Phase 3 clinical trial for the treatment of cutaneous T-cell lymphoma, there can be no assurance that a marketing authorization from the FDA or EMA will be successful. Further, there can be no assurance that RiVax® will qualify for a biodefense Priority Review Voucher (PRV) or that the prior sales of PRVs will be indicative of any potential sales price for a PRV for RiVax^®. Also, no assurance can be provided that the Company will receive or continue to receive non-dilutive government funding from grants and contracts that have been or may be awarded or for which the Company will apply in the future. These and other risk factors are described from time to time in filings with the Securities and Exchange Commission, including, but not limited to, Soligenix's reports on Forms 10-Q and 10-K. Unless required by law, Soligenix assumes no obligation to update or revise any forward-looking statements as a result of new information or future events.

Company Contact:

Jonathan Guarino, CPA, CGMA

Senior Vice President and Chief Financial Officer

(609) 538-8200 | www.soligenix.com

Soligenix, Inc.

29 Emmons Drive, Suite B-10

Princeton, NJ 08540

5

Exhibit 99.2

COVID - 19 Landscape and Applications NASDAQ: SNGX

Forward - Looking Statements This presentation contains forward - looking statements . All statements other than statements of historical facts contained in this presentation, including statements regarding our future results of operations and financial position, business strategy, prospective products and product candidates and their development, regulatory approvals, ability to commercialize our products and product candidates and attract collaborators, reimbursement for our product candidates, research and development costs, timing and likelihood of success, plans and objectives of management for future operations, our ability to obtain and maintain intellectual property protection for our product candidates and their development, competing therapies, and future results of current and anticipated products and product candidates, are forward - looking statements . These statements involve known and unknown risks and uncertainties , such as experienced with the COVID - 19 outbreak, and other important factors that may cause our actual results, performance or achievements to be materially different from any future results, performance or achievements expressed or implied by the forward - looking statements, many of which are disclosed in detail in our reports and other documents filed with the Securities and Exchange Commission . Because forward - looking statements are inherently subject to risks and uncertainties, some of which cannot be predicted or quantified and some of which are beyond our control, you should not rely on these forward - looking statements as predictions of future events . The events and circumstances reflected in our forward - looking statements may not be achieved or occur and actual results could differ materially from those projected in the forward - looking statements . Except as required by applicable law, we do not plan to publicly update or revise any forward - looking statements contained herein, whether as a result of any new information, future events, changed circumstances, or otherwise . Certain information contained in this presentation and statements made orally during this presentation relate to or are based on studies, publications, surveys and other data obtained from third - party sources . In addition, no independent source has evaluated the reasonableness or accuracy of Soligenix, Inc . internal estimates and no reliance should be made on any information or statements made in this presentation relating to or based on such internal estimates . 2

Agenda » Corporate overview Dr. Christopher Schaber, President & CEO, Soligenix » COVID - 19 and vaccine overview Dr. Axel Lehrer, Associate Professor, University of Hawaii » CiVax program overview Dr. Oreola Donini, CSO, Soligenix » Dusquetide in COVID - 19 Dr. Oreola Donini » COVID - 19 vaccine market Daniel Ring, MBA, Vice President, Business Development & Strategic Planning, Soligenix » Closing summary Dr. Christopher Schaber » Question and Answer All 3

Christopher Schaber, PhD » Chairman, President & CEO » 30 years of broad R&D and operational experience across pharmaceutical and biotech industry o Discovery Laboratories (COO) o Acute Therapeutics (Co - Founder) o Ohmeda Pharmaceuticals o The Liposome Company o Wyeth Ayerst » Detailed bio at: https://www.soligenix.com/about/executive - team / 4

Company Description Soligenix, Inc. is a late - stage biopharmaceutical company focused on developing and commercializing products to treat rare diseases where there is an unmet medical need Two areas of focus: » A Specialized BioTherapeutics segment dedicated to the development of products for orphan diseases and areas of unmet medical need in oncology and inflammation » A Public Health Solutions segment that develops vaccines and therapeutics for military and civilian applications in the areas of ricin exposure, emerging and antibiotic resistant infectious disease, and viral disease including Ebola, Marburg and COVID - 19 5

Development Pipeline – Rare Diseases Product Candidates Preclinical Phase 1 Phase 2 Phase 3 Market SGX301 Cutaneous T - Cell Lymphoma (CTCL) SGX942 Oral Mucositis in Head & Neck Cancer SGX203 Pediatric Crohn’s Disease** SGX201 Radiation Enteritis** Specialized BioTherapeutics Public Health Solutions** Product Candidates (FDA Animal Rule) Proof - of - Concept IND Phase 1 Phase 2/3 Market RiVax ® + ThermoVax ® – Vaccine Ricin Toxin Pre - Exposure CiVax™ + ThermoVax ® – COVID - 19 Vaccine SGX943 – Therapeutic Emerging Infectious Disease ThermoVax ® – Vaccine Heat Stabilization Technology Enrollment complete ; Ph . 3 data 4Q 2020* * Anticipated event and timing ** Potential value drivers dependent on continued government funding and/or other funding sources Initiation contingent upon additional funding and/or partnership* Initiation contingent upon additional funding and/or partnership* NIH Contract Award of $21.2M Ebola/Marburg: $700,000 Grant Subaward; Positive primary + Cycle 2 results Denotes funding in whole or in part by NIH, DTRA, BARDA and/or FDA ORPHAN & FAST TRACK DESIGNATION FAST TRACK DESIGNATION ORPHAN & FAST TRACK DESIGNATION FAST TRACK DESIGNATION ORPHAN & FAST TRACK DESIGNATION FAST TRACK USG awards of $900,000 to date; positive proof of concept preclinical data Collaboration with the University of Hawai ʻ i at Mānoa 6

Axel Lehrer, PhD » Associate Professor, Department of Tropical Medicine, Medical Microbiology and Pharmacology, John A. Burns School of Medicine, University of Hawaiʻi at Mānoa » 18 years of experience in vaccine research and development o Previous research in vaccine R&D with filoviruses (e.g., Ebola) and flaviviruses (i.e., Zika virus, Tick - borne encephalitis (TBE) virus, West Nile virus and Dengue virus ) o Developed protein expression methodologies for vaccine manufacture 7

COVID - 19: Disease Background » Respiratory illness caused by SARS - CoV - 2 virus o Droplet transmission is believed to be the major mode of transmission in enclosed spaces o Spike protein (trimeric glycoprotein on viral surface) is key to viral entry, utilizing the human ACE2 receptor, which is prevalent in the respiratory tract, ▪ Targeting of ACE2 may explain some of the varied disease presentations in COVID - 19 » Inflammatory response drives mortality o Response to viral infection engages the innate immune response – including BOTH the anti - infective and the inflammatory disease arms ▪ Inflammation may also arise from the adaptive immune cells (B/T cells) o Inflammatory response enhances damage to the lung (or other areas where the virus is present) ▪ Causes acute respiratory distress which is the primary driver of mortality 8

COVID - 19: Treatment Background » Treatment options focused on “severe” disease o Remdesivir shown to decrease length of hospital stay, but not to increase survival (yet) ▪ Anti - viral treatment administered IV and likely primarily targets systemic viral circulation o Dexamethasone may decrease mortality ▪ Anti - inflammatory steroid which may also increase the risk of secondary bacterial infections » Mild to moderate patients, although hospitalized, are treated with oxygen therapy but there are no approved, standard treatments o No treatments shown to prevent progression to more severe disease » There are no treatments for patients not requiring hospitalization 9

COVID - 19: Vaccine Background » Many vaccines in development – utilizing different vaccine platforms o Different platforms may be used to target different patient populations ▪ Mainly driven by safety profile o Different platforms have different logistical requirements ▪ Storage/distribution requirements – ambient temperature, refrigeration, freezing at - 20 ° C, - 70 ° C ▪ Dosage requirements – most believed to require at least 2 doses to raise the required immunity ▪ Manufacturing requirements – types of facilities differ according to vaccine platform » Durability of immune responses unknown o Will there be a requirement for yearly/seasonal vaccination as with flu? » Sufficiency of immune response (e.g., efficacy) unknown but Phase 3 studies correlating efficacy with immunogenicity measures are ongoing for candidates based on several platforms 10

Vaccine Platforms » Development Platforms: o Conventional (live attenuated, inactivated virus) o Subunit (conventional or recombinant) o Recombinant (genetic expression of antigen): ▪ Viral vectors (replicated limited or incompetent) – Adenovirus, chimp adenovirus, VSV, measles virus etc. ▪ RNA ▪ DNA 11 From: Vaccinology – an essential guide (Milligan and Barrett, Wiley, 2015)

Immune Response » Different platforms modulate different immune responses » For COVID - 19, emphasis has been placed on: o Total antibody response ▪ Can be raised by isolated pieces of the virus (e.g., pieces of protein) ▪ Antibodies to Receptor - binding domain are believed to inhibit viral entry o Th1 balanced response o Neutralizing antibody response o Cell mediated (T - cell) response ▪ Often associated with having intracellular expression of viruses ▪ Required for potent memory effect and viral clearance 12 From: Barrett, AD (2008). Nature Biotechnology 26, 525 - 526

Immune Response 13 From: Barrett, AD (2008). Nature Biotechnology 26, 525 - 526 Journal of Clinical and Experimental Hepatology DOI: (10.1016/j.jceh.202 0.06.003) » Live - attenuated vaccine ( LA) » Inactivated vaccine ( IA) » DNA vaccine ( DNA) » RNA vaccine (RNA ) » Viral vector replicating vaccine (VVR ) » Viral vector nonreplicating (VVNR ) » Virus - like particles (VLP ) » Subunit vaccine ( Subunit)

Vaccine Candidates 14 From: Barrett, AD (2008). Nature Biotechnology 26, 525 - 526 Platform Pre - clinical Phase I Phase II Phase III Inactivated 9 2 ? 3 live attenuated 4 protein subunits 61 5 4 ? VLP 14 1 DNA 12 4 ? RNA 21 2 2 ? 2 ? non - replicating viral vector 20 1 3 ? 1 replicating viral vector 18 Source: Milken Institute COVID - 19 tracker Accessed 09/07/2020

Oreola Donini, PhD » Senior Vice - President & Chief Scientific Officer » 20 years industry experience o Inimex Pharmaceuticals o ESSA Pharma, Inc. o Kinetek Pharmaceuticals » Focused preclinical and early clinical development o Lead programs in early manufacturing, GLP toxicology and pharmacology o Ricin toxin vaccine o Host innate immune modulator with anti - infective and anti - inflammatory activity » Detailed bio at: https://www.soligenix.com/about/executive - team / 15

Anti - viral Glycoprotein Vaccine Platform 16 » Antibody and cell - mediated responses preferred » Viral antigens are often multimeric viral surface glycoproteins » Platform developed in collaboration with University of Hawaii o Insect cell expression system to produce multimeric proteins with stable glycosylation patterns o CoVaccine HT™ adjuvant (licensed from BTG - Boston Scientific) stimulates humoral and cell mediated immunity o Thermostabilization platform to enable co - lyophilized formulations » Vaccines are individually lyophilized in vials and only need to be reconstituted with sterile water for injection immediately prior to use o At least 12 weeks stability at 40 ° C ( 104 ° F ) demonstrated

Soligenix: Anti - Viral Protein Vaccines » Gold standard vaccine platform for safety o Equally applicable to older populations and immunocompromised populations, allowing widest possible application » Antigen production o Stably transformed insect S2 expression system produces stable glycosylation combined with protein - specific affinity chromatography o Expression system previously used in clinical programs for West Nile and Dengue virus vaccines » Potency driven by characteristics of the adjuvant o Alum stimulates humoral immunity but not cell mediated immunity (anti - ricin toxin vaccine; RiVax ® ) o Licensed CoVaccine HT™ which stimulates BOTH antibody and cell - mediated immunity (licensed from BTG (Boston Scientific)) » ThermoVax ® – Soligenix’s thermostabilization platform o Unique, patented method to thermostabilize alum (previously problematic) o Proprietary method to stabilize nano - emulsions (like CoVaccine HT™) (applicable to viral vaccines against filoviruses, coronaviruses and flu) 17

CoVaccine HT™ – Nanoemulsion adjuvant 18 » Safety demonstrated in Phase 1 and Phase 2 clinical studies in a non - infectious disease context o MTD 10 mg/dose » Nonclinical efficacy data in the context of viral vaccines (e.g., EBOV, SUDV, MARV, Zika, Tick borne encephalitis) o Broad applicability to viral disease (including pandemic flu and coronaviruses) o Strong immunogenicity in COVID - 19 prototype vaccine o Demonstrated in mice and non - human primates » Demonstrated stability and potency after lyophilization o Maintain critical particle size after reconstitution o Maintains potency after reconstitution

TriFiloVax – Ebola and Marburg Vaccines CoVaccine - adjuvanted filovirus vaccine provided 100 % protection in a non - human primate challenge model with Marburg marburgvirus Market Opportunity » Filovirus infections ( Sudan virus, Marburg virus and Ebola virus ) are deadly; only Ebola vaccine is approved and requires ≤ - 60 ° C shipping/storage » Disease - endemic areas benefit from the ability to avoid cold - chain distribution » Government has placed priority on development activities, with Marburg marburgvirus an area of unmet medical need Development Status » Collaboration with the University of Hawai ʻ i at Mānoa and Hawaii Biotech, under NIH R01 grant » Demonstration of efficacy in non - human primates » Bi - and Tri - valent mixtures feasible 19 Survival after MARV Challenge

Glycoprotein Platform for COVID - 19 20 Parameter Filovirus Coronavirus Surface glycoprotein antigen x (GP) x (Spike) Multimeric glycoprotein structure x (trimer+) x (trimer) Humoral + cell mediated adjuvancy likely required x x Cell construct for S2 expression system x x Formulation conditions identified x (Pending) Mouse immunogenicity x x Primate immunogenicity x (Pending) Primate efficacy x (Pending) Adjuvant human safety x x Antigen/vaccine human safety

CiVax™ Benefits 21 » CoVaccine shown to elicit Th1 balanced humoral and cell mediated immunity with prototype Spike S1 protein antigen in Th2 - biased mice, yielding neutralizing antibodies of similar levels to convalescent plasma. Strong antibody response within 14 days of the first vaccination » Protein vaccines avoid the novelty risk of RNA and DNA vaccines (lack of regulatory precedent and vaccine durability), the contra - indications (immunocompromised) and complexity (immunity to vector) of viral vectored vaccines, the reversion risks of attenuated viruses and the potential dose limitations with inactivated viruses » Spike protein manufacturing uses stably transformed cell line with good preliminary yield (sub - cloning not yet conducted) and immunoaffinity chromatography » Vaccination with more complete Spike protein antigen (Spike #13) yields sera antibodies which recognize both the full length spike protein and the isolated RBD domain with high selectivity. Responses confirmed as early as 7 days after the first vaccination

CiVax™ Competitive Profile 22 Parameter / Platform Protein (Soligenix / UH) * Protein (NovaVax) rVSV chAd (AstraZeneca) Ad26 (Janssen) RNA (Moderna/ BioNtech) Ambient storage x ? × × × × Immune compromised populations? x x × × × ? Repeat vaccination possible? x x × Limited Limited x Single dose regimen? ? ? ? × × × Simple manufacturing / Scale Out x ? × × × x No risk of genomic integration x x × × × x Single vial formulation x × ? x x x Used in other approved vaccines (reduces regulatory risk) x x x (Ebola) × x (Ebola) × *uses a stably transformed expression cell line with protein specific affinity purification for antigen production, combined with a novel, clinically proven, adjuvant (CoVaccine), both of which will be combined with GRAS excipients to yield a thermostabilized formulation

WHO Target Product Profile (TPP) 23 WHO Preferred Characteristic CiVax™ TPP Thermostability (higher temperature preferred) x No contra - indications x Rapid onset of immunity x Single dose regimen (minimal: no more than 2) x Durability of at least 1 year (minimal: At least 6 months) ? Non - parenteral (minimal: any route) x (Needle free is possible, parenteral administration for first line product) Co - administration with other vaccines in long term x

CiVax™ – COVID - 19 Vaccine Candidate Proof of concept study with S1 Spike protein and CoVaccine HT™ adjuvant with rapid and potent onset of immunogenicity Market Opportunity » Pandemic response will require many different vaccines to produce adequate coverage worldwide » Rapid distribution enabled by thermostabilization / avoiding cold - chain » Government has placed priority on development activities Development Status » Proof of concept data in mice: o Single dose may be feasible (rapid onset within 7 days) o Th1 - biased immune response o Neutralizing response » Recombinant insect cell expression for full Spike protein stabilized in pre - fusion complex » Immunoaffinity chromatography purification developed 24 Post Dose 1 Post Dose 2 10 100 1000 10000 100000 a n t i - S A R S - 2 - S 1 I g G ( M F I ) CoVaccine Protein alone Adjuvant aloneAlhydrogel

CiVax™ – Proof of Concept Study 25 » Selective response » Th1 bias preferred for COVID - 19 vaccines o Th1 response demonstrated (IgG2a and IgG2b subtype responses) in BALB/c ( Th2 - biased ) mice with the use of CoVaccine o Superior response to alhydrogel (alum) – shows strong Th2 bias Isotype Characterization Th1 Balanced IgG1 IgG2a IgG2b IgG2c IgG3 IgM 10 100 1000 10000 100000 a n t i - S A R S 2 - S 1 I g G ( M F I ) CoVaccine Protein aloneAlhydrogel

CiVax™ – Proof of Concept Study 26 » Strong neutralizing antibody responses o PRNT90 = 1620 o As good as post - convalescent plasma » Enhanced cell mediated immunity o IFN response indicative of Th1 - biased T - cell memory response » Actively exploring the p ossibility for single dose formulation Cell - Mediated Immunity CoVaccine Alhydrogel Protein Naive 0 100 200 300 400 I F N - S F C p e r 1 0 6 s p l e n o c y t e s **** ****

CiVax™ – Proprietary Antigen 27 » Expression of full spike protein with mutation to lock the pre - fusion configuration » Immunoaffinity chromatography ensures proper / recognizable protein antigen » Immunogenicity as early as 7 days post - dose o CoVaccine improves kinetics and magnitude of response » Rapid development possible ( manufacturing scale up, Phase 1 study initiation) with funding

CiVax™ – Proprietary Antigen » Strong Th1 response in adjuvanted vaccine after 2 nd dose o IgG2a and IgG2b represent the Th1 response o Study conducted in Swiss Webster mice (outbred) 28

CiVax™ – Proprietary Antigen » Strong cell mediated immune response after 2 nd dose o Preliminary data show high amount of cells secreting IFN - representing recall memory response of splenic T - cells 29

Dusquetide – Potential Therapeutic in COVID - 19 30 » Dusquetide (active ingredient in SGX942 for oral mucositis) has been shown to control the inflammatory response to infection while enhancing the anti - infective and tissue healing pathways » Potential to provide benefit in preventing progression to and/or treating moderate to severe disease arising from SARS - CoV - 2 infection: o Potentially administer to all hospitalized patients to prevent progression to severe respiratory illness o Potentially administer to moderate to severe patients to aid in the control of infection in conjunction with remdesivir » Soligenix continues to seek non - dilutive funding to potentially advance the therapeutic use of dusquetide in emerging infectious diseases, including COVID - 19 o Funding agencies to date have been focused on re - purposing approved drugs, as opposed to evaluating drugs in clinical development o With Phase 3 outcome for dusquetide in oral mucositis rapidly approaching (Q4 2020) and with very benign safety profile observed to date, Soligenix continues to pursue multiple funding pathways

Daniel Ring, MBA » Vice President, Business Development and Strategic Planning » 22 years industry experience, o Business development experience includes work with large (e.g., Merck & Co.) and small companies o Experience with growing commercial operations (e.g., Exela Pharma Sciences LLC) » Detailed bio at: https://www.soligenix.com/about/executive - team / 31

COVID - 19 Vaccine Market Potential 32 Sources: *Goldman Sachs research note July 29, 2020, assumes 50% vaccination rate and two does at $19.50 / dose. § Market Insights report. ± CDC Potential Value » Global COVID - 19 vaccine market is estimated to be worth approximately $23 Billion* o Current entire global vaccine market is approximately $40B* » Pandemic response will require many different vaccines for worldwide coverage » Long term value of re - vaccination of COVID - 19 similar to seasonal flu vaccines o U.S . influenza vaccine market valued at US$ 2.6 billion in 2019 § ; o 2019 - 20 US flu season resulted in 24,000 – 62,000 flu deaths ± o COVID - 19 vaccines will likely require multiple doses over many years to achieve herd immunity » Size of market: Billions of doses will be needed to satisfy global requirements providing room for multiple suppliers » Distribution advantage: Employs Soligenix’s thermostabilization platform ThermoVax ® , which simplifies and broadens distribution by avoiding cold - chain » Gold standard vaccine platform : Tried and true vaccine technology with p otential lower regulatory risk and higher public acceptance » Seasonal use: May be used as an annual or semi - annual booster irrespective of the vaccine utilized for the first vaccination, if the need were to arise CiVax™ Strategic Rationale

First Generation Vaccines vs. Second Generation CiVax™ » First generation vaccines utilize more novel and less understood technologies o Potential to introduce additional regulatory risk and may limit repeat use o “Tried and True” protein subunit vaccine has established regulatory and safety precedent ▪ Introduction of novel CoVaccine adjuvant expands the applicability of the standard protein vaccine approach o “Tried and True” approach may address more hesitant populations ▪ Potential slow adoption of novel technologies; data show 30% of people say they will take 1st gen vaccine; 40% will wait 6 - 12 months and 30% >12 months » First generation vaccines may potentially limit availability due to both cold - chain logistical and safety constraints o CiVax may be more easily distributed (e.g., ambient temperature) o CiVax may address these other populations (e.g. elderly, immunocompromised) » First generation vaccines may have limited utility for repeat vaccination o CiVax may be used to boost any other vaccine platform used for earlier immunizations » First generation vaccines may identify “correlates of immune protection” o Potential to accelerate clinical development of “tried and true” vaccines with very low safety risk 33

Christopher Schaber, PhD » Chairman, President & CEO » 30 years of broad R&D and operational experience across pharmaceutical and biotech industry o Discovery Laboratories (COO) o Acute Therapeutics (Co - Founder) o Ohmeda Pharmaceuticals o The Liposome Company o Wyeth Ayerst » Detailed bio at: https://www.soligenix.com/about/executive - team / 34

In Summary » Multiple products with fast track and/or orphan designation, each of which holds potential for significant commercial returns » Phase 3 assets with data readout approaching o Cutaneous T - cell lymphoma (SGX301) – Positive statistically significant final results achieved ; follow - up ongoing o Oral mucositis in head & neck cancer (SGX942) – Pivotal study in progress; interim analysis complete ; final results 4 Q 2020 » Potential for significant near - term value creation » Collaborations with biotech, academia and government agencies » CiVax™ : COVID - 19 vaccine in development o Target product profile: 1 or 2 dose thermostable vaccine reconstituted water for injection immediately prior to use that elicits Th1 balanced antibody response and cell mediated response to SARS - CoV - 2 » Dusquetide : COVID - 19 therapeutic potential o Investigating as a potential treatment for hospitalized patients with either mild to moderate or moderate to severe COVID - 19 35

Question & Answer Session NASDAQ: SNGX