Exhibit 99.1

To the shareholders of

NLS Pharmaceutics AG, Stans, Switzerland

Stans, 21 May 2021

Invitation to the

Ordinary Shareholders’ Meeting of NLS Pharmaceutics AG, Stans

Dear Shareholder,

The board of directors of NLS Pharmaceutics AG (the “Board of Directors”), with registered office at Alter Postplatz 2, 6370 Stans, Switzerland (the “Company”) is pleased to invite you to the ordinary shareholders’ meeting of the Company. The shareholders’ meeting will be held as follows:

Due to the current restrictions resulting from the global COVID-19 pandemic, the meeting will be held in accordance with art. 27 para. 1 letter b COVID-19-Ordinance 3, i.e., without physical presence of the shareholders. Shareholders will have the possibility to exercise their shareholder rights only through the independent proxy. Although you will not attend the meeting, your vote is important.

Please find enclosed to your individual invitation a Proxy Card. The agenda items to be voted on and the voting instructions for the proxy are provided below:

The agenda items and proposals of the Board of Directors are as follows:

Proposal

The Board of Directors proposes to elect KBT Treuhand AG Zürich, Zimmergasse 16, 8008 Zurich, Switzerland (represented by Sandro Müller), as independent proxy until the next annual ordinary shareholders’ meeting.

Proposal

The Board of Directors proposes the approval of the statutory financial statements of the Company for the business year 2020.

Proposal

The Board of Directors proposes that the shareholders approve that the net loss of CHF 3,465,674 for the business year 2020 is added to the loss brought forward of CHF 3,804,905 resulting in a new balance of loss brought forward of CHF 7,270,579.

Proposal

The Board of Directors proposes that the shareholders grant discharge to each member of the Board of Directors and of the Executive Management from liabilities for their activities for the business year 2020.

Furthermore, the Board of Directors notes the resignation of Pascal Brenneisen as a member of the Board of Directors with effect as of 28 February 2021 and proposes, that he shall be granted discharge for the business year 2020.

Proposal

The Board of Directors proposes to re-elect Ronald Hafner as Chairman of the Board of Directors and Alexander Zwyer, Myoung-Ok Kwon and Stig Lökke Pedersen as members of the Board of Directors for another term lasting until the next annual ordinary shareholders’ meeting.

Proposal

The Board of Directors proposes to elect Gian-Marco Rinaldi Diaz de la Cruz, from Lugano, in Zurich, as a new member of the Board of Directors for a term lasting until the next annual ordinary shareholders’ meeting.

Explanation

In the opinion of the Board of Directors, the candidate presented for election as proposed by the Board of Directors has the required expertise to adequately supervise all activities undertaken by the persons entrusted with the Executive Management.

Proposal

The Board of Directors proposes that Ronald Hafner and Myoung-Ok Kwon shall be elected as members of the Compensation, Nomination and Governance Committee for a term lasting until the next annual ordinary shareholders’ meeting.

Proposal

The Board of Directors proposes to re-elect PricewaterhouseCoopers AG, Zurich, as auditor of the Company for another term lasting until the next annual ordinary shareholders’ meeting.

Proposal

The Board of Directors proposes the approval of the maximum aggregate amount of CHF 105,000 (cash base compensation plus social security costs) for the fixed compensation of the members of the Board of Directors for the following term of office lasting until the next ordinary shareholders’ meeting.

Proposal

The Board of Directors proposes the approval of the grant of equity or equity linked instruments with maximum aggregate amount of CHF 1,214,680 (equity or equity linked instruments plus social security costs) for the compensation of the members of the Board of Directors for the following term of office lasting until the next ordinary shareholders’ meeting.

Proposal

The Board of Directors proposes the approval of the maximum aggregate amount of CHF 1,220,400 (cash compensation plus social security costs) for the fixed compensation of the members of the Executive Management for the financial year 2022.

Proposal

The Board of Directors proposes the approval of the maximum aggregate amount of CHF 472,500 (cash compensation plus social security costs) for the variable compensation of the members of the Executive Management for the financial year 2022.

Proposal

The Board of Directors proposes the approval of the grant of equity or equity linked instruments with maximum aggregate amount of CHF 2,818,050 (equity or equity linked instruments plus social security costs) for the members of the Executive Management for the financial year 2022.

Administrative Information

Please note the following instructions with respect to the participation in the Ordinary Shareholders’ Meeting:

Shareholders who are entered in the shareholder register maintained by our transfer Agent VStock Transfer, LLC as of April 30, 2021, 10 pm CET (reporting date) are entitled to exercise their shareholder rights with respect to the Ordinary Shareholders’ Meeting. During the period from May 1, 2021 until and including 17 June 2021, no entries of shares will be made in the shareholder register.

In light of the current epidemic situation in Switzerland and the corresponding legal basis, there will be no physical attendance of shareholders at the Ordinary Shareholders’ Meeting. Based on art. 27 para. 1 letter b COVID-19-Ordinance 3 the shareholders will have the possibility to exercise their shareholders’ rights through the independent proxy only.

Shareholders may only be represented by the independent proxy, KBT Treuhand AG Zürich, Zimmergasse 16, 8008 Zurich, Switzerland (represented by Sandro Müller). The independent proxy will be physically present at the Ordinary Shareholders’ Meeting to vote on behalf of the shareholders who issued instructions to him.

If the independent proxy cannot be present, the Board of Directors will appoint a new independent proxy. The powers of attorney granted to the independent proxy will also be valid for any new independent proxy appointed by the Board of Directors.

In order to authorize the independent proxy, the shareholders may vote by returning the marked, signed and dated Proxy Card by e-mail or mail in line with the instructions given therein, or by voting on the internet (go to http://www.vstocktransfer.com/proxy, click on Proxy Voter Login and log-on using the control number provided in the Proxy Card). Voting instructions must be given no later than 14 June 2021 (received by 12:00 CET).

As of May 14, 2021, the statutory financial statements including the report of statutory auditors, for the financial year 2020 accessed on our website at: https://nlspharma.com/investors/financial-information/

All documents have likewise been laid out for inspection at the headquarters of the Company.

Please Vote, Sign, Date and Return Promptly in the Enclosed Envelope. ALL VOTES MUST BE RECEIVED BY JUNE 14, 2021.

Annual General Meeting Proxy Card - NLS Pharmaceutics Ltd.

The Board of Directors recommends a vote of “FOR” for Proposals 1-9.5

▼ DETACH PROXY CARD HERE TO VOTE BY MAIL ▼

(Continued on Reverse)

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NLS PHARMACEUTICS LTD.

Annual Meeting of Shareholders

June 17, 2021

The undersigned, a shareholder of NLS Pharmaceutics Ltd., (the “Company”), hereby appoints KBT Treuhand AG Zurich represented by Sandro Mueller and proxy of the undersigned, with full power of substitution, for and in the name of the undersigned, to vote and otherwise act on behalf of the undersigned at the annual general meeting of shareholders of the Company to be held on Thursday, June 17, 2021, at the premises of Wenger & Vieli AG, Dufourstrasse 56, 8008 Zürich, Switzerland, at 4:00 p.m. CET (10:00 a.m. EST), or at any adjournment(s) or postponement(s) thereof, with respect to all of the ordinary shares, of the Company (the “Shares”) which the undersigned would be entitled to vote, with all powers the undersigned would possess if personally present, provided said proxies are authorized and directed to vote as indicated with respect to the matter set forth below this Proxy. All shares represented by properly executed proxies received prior to or at the Meeting and not revoked prior to, or at, the Meeting in accordance with the procedures described in the proxy statement, will be voted as specified in the instructions indicated in such proxies. Subject to applicable law, in the absence of instructions, the shares represented by properly executed and received proxies will be voted “FOR” all of the proposed resolutions to be presented at the Meeting for which the Board recommends a vote “FOR” Proposals 1 through 9.5.

For all disputes arising out of or in connection with this Proxy, the ordinary courts at the registered domicile of the Company are exclusively competent. All obligations and rights arising out of or in connection with this proxy are governed by Swiss Law.”

This proxy also delegates, to the extent permitted by applicable law, discretionary authority to vote with respect to any other business which may properly come before the annual general meeting or any adjournment(s) or postponement(s) thereof.

PLEASE COMPLETE, DATE AND SIGN THIS FORM OF PROXY AND E-MAIL OR MAIL THE ENTIRE PROXY PROMPTLY, IN ACCORDANCE WITH THE INFORMATION PROVIDED ON THE FRONT PAGE, IN ORDER TO ASSURE REPRESENTATION OF YOUR SHARES. IF THE FORM OF PROXY IS MAILED IN THE UNITED STATES IN THE ENCLOSED ENVELOPE, NO POSTAGE NEED BE AFFIXED.

▼ DETACH PROXY CARD HERE TO VOTE BY MAIL ▼