UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
WASHINGTON, D.C. 20549
 
FORM 8-K
CURRENT REPORT
Pursuant to Section 13 or 15(d) of the
Securities Exchange Act of 1934
Date of report (Date of earliest event reported): December 28, 2006
 
BTHC III, INC.
(Exact name of registrant as specified in Charter)
         
DELAWARE   0-51891   20-4494098
(State or other jurisdiction
Of incorporation)
  (Commission
File Number)
  (IRS Employer
Identification No.)
     
2595 Jason Court    
Oceanside, CA   92056
(Address of principal executive offices)   (Zip Code)
Registrant s telephone number, including area code:     (972) 233-0330
12890 Hilltop Road
Argyle, TX 76226

(Former name or former address, if changed since last report)
Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions (see General Instruction A.2. below):
o Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)
o Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)
o Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))
o Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))
 
 

 

 


 

Item 1.01  
Entry into a Material Definitive Agreement.
On December 28, 2006, BTHC III, Inc., a Delaware corporation (the “Registrant” or “BTHC”) entered into a Share Exchange Agreement (the “Exchange Agreement”) by and among International Stem Cell Corporation, a California corporation (“International Stem Cell” or “ISC”), Halter Financial Investments, LP and the shareholders of International Stem Cell by and through the Shareholder Representative named therein (the “ISC Shareholders”). Pursuant to the terms of the Exchange Agreement, the Registrant issued 33,111,502 shares of its common stock, par value $0.001 per share (the “BTHC Common Stock”) in exchange for all of the issued and outstanding stock of International Stem Cell (the “Share Exchange”) held by the ISC Shareholders. After giving effect to the Share Exchange, the ISC Shareholders owned 93.7% of the Registrant’s issued and outstanding shares.
The issuance of the shares of BTHC Common Stock to the ISC Shareholders in the Share Exchange is intended to be exempt from registration under the Securities Act of 1933, as amended (the “Securities Act”), pursuant to Section 4(2) thereof. As such, the shares of BTHC Common Stock issued in the Share Exchange may not be offered or sold unless they are registered under the Securities Act, or an exemption from the registration requirements of the Securities Act is available. No registration statement covering these securities has been filed with the United States Securities and Exchange Commission (“SEC”) or with any state securities commission in respect of the Share Exchange.
The foregoing description of the Exchange Agreement does not purport to be complete and is qualified in its entirety by reference to the Exchange Agreement, which is attached hereto as Exhibit 2.1 and incorporated by reference.
Item 2.01  
Completion of Acquisition or Disposition of Assets.
The information provided in Item 1.01 of this Current Report on Form 8-K is incorporated hereby by reference. In addition, pursuant to Item 2.01(f) of Form 8-K, we are providing below the information that would be required if we were filing a Form 10-SB. References to “we,” “us” or “our” throughout this Current Report on Form 8-K refer to BTHC, International Stem Cell and Lifeline Cell Technology, LLC (“Lifeline”) together, unless the context indicates otherwise.
Changes Resulting from the Share Exchange
As a result of the Share Exchange, International Stem Cell became our wholly-owned subsidiary and the Registrant ceased being a shell company as such term is defined in Rule 12b-2 under the Securities Exchange Act of 1934, as amended (the “Exchange Act”).
We intend to carry on International Stem Cell’s business. International Stem Cell is headquartered in Oceanside, California, and has a research facility in Walkersville, Maryland. The contents of International Stem Cell’s website are not part of this Current Report on Form 8-K and should not be relied upon with respect thereto.

 

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Pre-exchange stockholders of our company will not be required to exchange their existing BTHC stock certificates for certificates of International Stem Cell, since all outstanding shares are in book-entry form only.
Accounting Treatment
The Share Exchange is being accounted for as a “reverse merger,” since as a result of the Shares Exchange the shareholders of International Stem Cell now own a majority of the outstanding shares of BTHC Common Stock. International Stem Cell is deemed to be the acquirer in the Share Exchange for accounting purposes and, consequently, the assets and liabilities and the historical operations that will be reflected in the financial statements will be those of International Stem Cell and will be recorded at the historical cost basis of International Stem Cell. As a result of the Share Exchange, there was a change in control of the Registrant, however, the Registrant will continue to be a “small business issuer,” as defined under the Exchange Act.
Election to Board of Directors; Appointment of Officers
In connection with the Share Exchange, Kenneth Aldrich was appointed to the Board of Directors of the Registrant (the “Board of Directors” or the “Board”) and will serve as the Chairman of the Board. Jeff Krstich and William B. Adams were appointed as the Chief Executive Officer and Chief Financial Officer of the Registrant, respectively. Jeffrey Janus was appointed as the President of the Registrant and Chief Executive Officer of Lifeline, ISC’s wholly-owned subsidiary.
Registration Rights
In connection with the Share Exchange, we assumed the obligation to register (i) up to 12,000,000 shares of common stock issued by International Stem Cell in a private placement (the “ISC Private Placement”); (ii) up to 2,400,000 shares of BTHC Common Stock underlying a warrant issued to the placement agent for the ISC Private Placement (the “Warrant Shares”) and; (iii) 1,629,623 shares underlying warrants held by ISC shareholders (the “ISC Warrant Shares”). The registration statement (the “Registration Statement”) is required to be filed by February 27, 2007.
Lock-Up Agreements
In connection with the ISC Private Placement, the former officers and directors of International Stem Cell entered into “lock-up” agreements. Each lock-up agreement provides that the shares of BTHC Common Stock issued to the ISC officers and directors in the Share Exchange may not be, directly or indirectly, sold, subject to a contract for sale or otherwise transferred for a period of 180 days following the effective date of a Registration Statement.
Pursuant to the terms of the Financial Advisory Agreement, dated October 18, 2006, between ISC and Halter Financial Group, L. P. (“HFG”), HFG agreed that without the prior written consent of ISC, it will not sell, transfer or otherwise dispose of greater than 1/12th of its holdings in BTHC every 30 days commencing on December 28, 2006. However, in the event HFG does not sell or otherwise dispose of all of the allotted number of BTHC shares that may be sold in a given 30 day period, HFG may sell such unsold shares at any time thereafter.

 

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Description of International Stem Cell’s Business
BUSINESS OVERVIEW
International Stem Cell was incorporated in the state of California in June 2006 for the purpose of restructuring the business of Lifeline, which was organized in the state of California in August 2001. Lifeline is a wholly-owned subsidiary of International Stem Cell and all of ISC’s operations are conducted through Lifeline. International Stem Cell is a biotechnology company currently focused on developing therapeutic products and research products.
In the area of therapeutic product development, our objective is to create an unlimited source of human cells for use in the treatment of several diseases including diabetes, liver disease and retinal disease through cell transplant therapy. In furtherance of this objective, ISC is currently developing (i) stem cells that are comparable in function to, but distinct in derivation from, embryonic stem cells from which cells for human transplant can be derived, (ii) techniques to cause those cells to be “differentiated” into the specific cell types required for transplant, and (iii) manufacturing protocols to produce these cells without contamination with animal by-products in compliance with U.S. Food and Drug Administration (“FDA”) requirements. While ISC’s cell lines are comparable to embryonic cell lines because they have the potential to become any cell in the human body through differentiation, the development of our cell lines does not require the use of fertilized eggs or the destruction of any embryos created through fertilization.
Incidental to the research being conducted in the development of therapeutic products, we have developed research products (specialized cell systems, media and reagents for use in stem cell and other medical research) which we have commercialized and are selling to academic institutions, governmental entities and commercial research companies. The sale of these research products provides us with revenue to support the development of therapeutic products.
According to the National Institutes of Health, research on stem cells is advancing knowledge about how an organism develops from a single cell and how healthy cells replace damaged cells in adult organisms. This area of science is also leading scientists to investigate the possibility of cell-based therapies to treat disease, which is often referred to as regenerative or reparative medicine. A potential application of human stem cells is the generation of cells and tissues that may be used for cell-based therapies. Today, donated organs and tissues are often used to replace ailing or destroyed tissue, but the need for transplantable tissues and organs far outweighs the available supply. Stem cells, directed to differentiate into specific cell types, offer the possibility of a renewable source of replacement cells and tissues to treat diseases including diabetes, liver disease and retinal disease.

 

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Stem cells are undifferentiated primary cells that have the potential to become any tissues and organs of the body. However, stem cell therapies have technical, ethical and legal hurdles to overcome before they will be able to be used to effect tissue and organ repair. To realize the promise of cell-based therapies for the treatment of diseases, scientists must be able to manipulate stem cells so that they possess the necessary characteristics for successful differentiation, transplantation and engraftment. The following is a list of some of the major steps in successful cell-based treatments that scientists will have to learn to precisely control to ready such treatments for clinical use. To be useful for transplant purposes, stem cells must be reproducibly made to:
   
proliferate extensively and generate sufficient quantities of tissue;
   
differentiate into the desired cell type(s);
   
survive in the recipient after transplant;
   
integrate into the surrounding tissue after transplant;
   
function appropriately;
   
avoid harming the recipient; and
   
avoid or reduce the problem of immune rejection.
We believe that the market for our products will be substantial given the current limited supply of human cells required to make transplants possible, the need for cells that will not be rejected, and the need for cells produced without contamination by animal by-products. Addressing these core issues will provide an excellent opportunity for the commercialization of our products.
In addition to the work we are doing to develop cells for therapeutic cell transplant, we are engaged in the development, production and sale of specialty research products. This portion of our business is focused on the needs of stem cell researchers for specialized cells, media and reagents used in the development of therapeutic products.
FREQUENTLY ASKED QUESTIONS ABOUT STEM CELLS
What are Stem Cells?
Cells are the basic living units that make up a human being. Stem cells have two important characteristics that distinguish them from other types of cells. First, they are unspecialized cells that renew themselves for long periods of time. Second, under certain physiologic or experimental conditions, they can be induced to become cells with special functions such as the beating cells of the heart muscle or the insulin-producing cells of the pancreas. Scientists currently work with two kinds of stem cells from animals and humans: embryonic stem cells and adult stem cells, which have different functions and characteristics. We are developing a third category of stem cells that we believe will have the therapeutic advantages as embryonic stem cells without the difficulties discussed herein.

 

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What are Embryonic Stem Cells?
Embryonic stem cells are derived from embryos that develop from eggs that have been fertilized in vitro—typically in an in vitro fertilization clinic—which are donated for research purposes with informed consent of the donors. They are not derived from eggs fertilized in a woman’s body. The embryos from which human embryonic stem cells are derived are typically four or five days old and are a hollow microscopic ball of cells called the blastocyst. Embryonic stem cells are grown in a laboratory through a process known as cell culture.
Human embryonic stem cells, or hES cells, are isolated by transferring the inner cell mass into a laboratory culture dish that contains a nutrient broth known as a culture medium. The cells then divide and spread over the surface of the dish. Over the course of several days, the cells of the inner cell mass proliferate and begin to crowd the culture dish. When this occurs, they are removed and plated into several fresh culture dishes. The process of replating the cells is repeated many times and for many months. After six months or so, the original small cluster of cells of the inner cell mass yields millions of embryonic stem cells. Once cell lines are established, or even before that stage, batches of them can be frozen and shipped to other laboratories for further culture and experimentation.
Why are embryonic stem cells important?
Embryonic stem cells are of interest because of their ability to be differentiated, or develop into virtually any other cell made by the human body. In theory, if stem cells can be grown and their development directed in culture, it would be possible to grow cells for the treatment of specific diseases. The first potential applications of human embryonic stem cell technology may be in the area of drug discovery. The ability to grow pure populations of specific cell types offers a proving ground for chemical compounds that may have medical importance in that it may ultimately permit the rapid screening of chemicals. Treating specific cell types and measuring their response may offer an expedited methodology to ascertain chemicals that can be used to treat the diseases that involve those specific cell types.
The study of human development may also benefit from embryonic stem cell research in that understanding the events that occur at the first stages of development has potential clinical significance for preventing or treating birth defects, infertility and pregnancy loss. The earliest stages of human development have been difficult or impossible to study. Human embryonic stem cells offer insights into developmental events that cannot be studied directly in humans in utero or fully understood through the use of animal models.
What are Adult Stem Cells?
An adult stem cell is an undifferentiated cell found among differentiated cells in a tissue or organ. An adult stem cell can renew itself and can differentiate to yield the major specialized cell types of the tissue or organ. These cells can be isolated from many tissues, including the brain. The most common places to obtain these cells are from the bone marrow that is located in the center of some bones and from umbilical cord blood obtained at birth.

 

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Why Not Use Stem Cells Derived from Adults?
There are several approaches now in human clinical trials that utilize mature stem cells (such as blood-forming cells, neuron-forming cells and cartilage-forming cells). However, adult stem cells are limited in their inability to proliferate in culture. Unlike embryonic stem cells, which have a capacity to reproduce indefinitely in the laboratory, adult stem cells are difficult to grow in the lab and their potential to reproduce diminishes with age. Therefore, obtaining clinically significant amounts of adult stem cells may prove to be difficult.
What is Therapeutic Cloning?
Cloning is simply using the natural process of cell division to make exact copies of a cell. Cloning to make cells creates many identical cells called a “cell line” and cloning to make cells for medical use is generally called “therapeutic cloning.” Therapeutic cloning is not the same thing as cloning an entire animal, which is called “reproductive cloning.” Therapeutic cloning never creates a complete human being. We work only in the field of therapeutic cloning.
Why is Stem Cell Research Controversial?
The sources of some types of stem cells cause social and religious controversy. Some scientists obtain stem cells from aborted fetal tissue, causing opposition from those opposed to abortion. Another controversial source of stem cells are the residual frozen human fertilized eggs (embryos) that remain after vitro fertilization procedures. A final controversial source of stem cells are those obtained from very early stage embryos created by therapeutic cloning because this process of obtaining stem cells results in the destruction of these early-stage embryos.
Is Stem Cell Research Banned in the United States?
Embryonic stem cell research, in general, is not banned in the United States. Work by private organizations is not restricted except by the restrictions applicable to all human research. In addition, Proposition 71 in California, which voters approved in November 2006, specifically allows state funds to be used for stem cell research.
Why Not Use the Currently “Approved” Embryonic Stem Cells Lines?
The human embryonic stem cell lines approved by President George W. Bush were all produced using animal protein. We believe that this will likely make them unsuitable for human therapeutic purposes and perhaps even for research into human disease. We have developed technologies to create human embryonic stem cell lines that will be free of non-human materials.
How Will Stem Cells from International Stem Cell be Different?
Our research is based on perfecting proprietary techniques for deriving stem cells through a technology, based on parthenogenesis, which could result in the creation of human cells that have the same capacity to become other cells just as do embryonic stem cells. However, this process, would not use fertilized human eggs or cause the destruction of such eggs. From the stem cells we create, we will conduct the research to develop specialized cells (such as liver, pancreatic and retinal cells) needed for transplantation. We do not obtain stem cells from fetal tissue from abortion clinics and our technology does not require the use of discarded frozen human embryos. We do not anticipate using such sources in the future.

 

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ETHICAL ISSUES
The use of embryonic stem cells derived from fertilized human eggs has created an ethical debate in the United States and around the world. However, since no fertilized human eggs are used in creating our cells and no fertilized human embryo is being created or destroyed, our hope is that our success in perfecting parthenogenesis will resolve many of the current ethical controversies that surround traditional embryonic stem cell research.
We also own the worldwide rights to use in our chosen therapeutic fields, a technology known as Somatic Cell Nuclear Transfer to create human stem cells. The President’s Council on Bioethics, as reported in the publication “Reproduction and Responsibility — The Regulation of New Biotechnologies,” 2004, has agreed on a series of recommendations for the use of such technology, addressed to both the government and to the relevant scientific and medical practitioners for professional self-scrutiny. In addition, countries such as the United Kingdom have made similar recommendations. Although we have chosen for now to pursue our own proprietary technology, we have implemented the relevant recommendations from this study into our research practices and will continue to adhere to internationally accepted standards regarding the use of this technology in obtaining and using human embryonic stem cells for our therapeutic research.
OUR TECHNOLOGY
With the assistance of our Chief Scientist, Dr. Elena Revazova, we are perfecting a proprietary patent pending process, based on parthenogenesis, for the creation of new stem cell lines that we believe will have all the beneficial characteristics of traditional embryonic stem cells. Our technology allows embryonic-like stem cells to be created without the use of fertilized embryos or fertilized human eggs (called “oocytes”). This process results in the creation of embryonic-like stem cells that because of their DNA complement, have the potential to become cells that will not be rejected by some patients. These cells could be used to create stem cell “banks” in which cells could be stored and matched to a patient’s immune system when needed for transplantation. Though not currently our primary area of focus, Somatic Cell Nuclear Transfer, a process to which we also hold a license, can use a patient’s own cells to create stem cells having the same genetic makeup as the patient, thus avoiding immune rejection, the most common cause of transplant failure. This technology, however, is not currently our primary area of focus.
OUR PRODUCTS
Specialty Research Products
A critical element for any researcher seeking to develop a therapeutic cell from either a human embryonic stem cell or an adult stem cell is causing the stem cell to change (“differentiate”) into the specific cell needed for a particular therapy. The challenge is to discover the proper set of culture conditions (combinations of proteins, salts, temperatures and hundreds of other environmental factors) to change stem cells into the specific cell types that can be used to cure specific diseases; then develop the procedures needed to produce such cells on demand as needed for human therapy. This process is driven in large part by the “media” and the other added chemicals (called “reagents”) used to develop the cells. The type of media and reagents used can dictate what kind of cells will be produced and is critical to the process of developing cell transplants from differentiated stem cells.

 

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Our research products consist of cells, growth media and related cell-based products essential to the process of creating and differentiating stem cells. The customers for these products are academic research centers, government research centers, and corporations engaged in developing cell-based therapies.
Our first specialty research product called a “Cell System,” was launched in limited release in January 2006. Seven additional products have been developed since that date and in December 2006 we launched all eight of these product systems at the American Society of Cell Biology Conference which was held in San Diego, California.
Our research products include:
   
Fibrolife TM a serum-free human fibroblast medium.
   
Human fibroblast cells for use as feeder layers to grow human embryonic stem cells (eliminates contamination from mouse cells).
   
Two types of low serum human endothelial media
  1.  
VascuLife TM VEGF
 
  2.  
VascuLife TM EnGS.
   
Human endothelial cells. (Endothelial cells form blood vessels).
   
Line of adult neural stem cells with the ability to produce neurons that can survive in low-oxygen and low glucose conditions, a product useful for the discovery of drugs for the treatment of strokes.
   
Two types of media for the culture of the adult neural cells
  1.  
NeuralLife TM ags NSC expansion medium kit
 
  2.  
NeuralLife TM ags NSC differentiation medium kit.
Products such as these are essential to the development of our own proprietary therapeutic products and are a natural adjunct to that endeavor. The sale of these products to other stem cell-related researchers and businesses is expected to benefit us in several ways: (1) it provides revenue to help support our therapeutic research, (2) it may provide us with an opportunity to preview stem cell work being conducted throughout the world, and (3) if our products are adopted by a successful producer of therapeutic cells, we have the potential of becoming a supplier in a much broader market than research.
Further, because of the process by which therapeutic products are developed and submitted to the FDA for approval, the media and reagents used in developing cells for clinical trials tend to a large degree to become “baked in” to the final therapeutic product. Because of a reluctance or legal inability to change the process of creating the therapeutic product once it has been approved, if another company uses our media and reagents to develop an FDA approved product, we may become the sole approved supplier of these media and reagents for the manufacture of that product.

 

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Our human cell culture products also consist of standardized living cells, including fully functional adult cells and (non-embryonic) stem cell lines. The cells are provided frozen in vials containing approximately 500,000 cells each, or are plated into flasks. Each Cell System will be quality tested for the expression of specific markers (to assure the cells are the correct type) for proliferation rate, viability, morphology and for the absence of pathogens. Each Cell System will have associated donor information.
In addition to our Cell System, pursuant to the terms of a License Agreement with Advanced Cell Technology, Inc. (“Advanced Cell Technology”), we will manufacture and sell embryonic stem cell products developed by Advanced Cell Technology. The first products we expect to release are (i) medium optimized for the growth of human embryonic stem cells, and (ii) pre-coated tissue culture plates for the serum-free and feeder-layer-free culture of embryonic stem cells.
Our long term plans for additional product offerings based on the technology licensed from Advanced Cell Technology include:
   
Stem cells derived functional human liver cells provided in plates or frozen (a byproduct of therapeutic research). These cells must have active and inducible enzyme systems, they must have a correct morphology, they must express albumin and they must attach to the cell culture dish.
   
Stem cells derived functional islet cells provided in plates or frozen. These cells must produce and express insulin in response to glucose.
   
A complete line of reagents for the culture and differentiation of embryonic stem cells.
Therapeutic Products
We have already used human stem cells to create retinal cells known as retinal pigment epithelial, or RPE. We are currently expanding these cells as part of pre-clinical trials, resulting in animal implantation in 2007.
We are in the process of developing specialized liver cells for use in the treatment of liver disease and pancreatic “islet” cells to treat diabetes as the third target.
OUR MARKETS
Therapeutic Market
Retinal Diseases - Diseases involving retinal degeneration include age-related macular degeneration (“AMD”) and retinitis pigmentosa (“RP”). These diseases are characterized by the death of critical photoreceptor cell called rods and cones. Photoreceptor death is due to an abnormality and/or to disruption or death of supportive cells called retinal pigment epithelial (“RPE”) cells. The use of hES cells may prove beneficial in the treatment of AMD and RP as retinal cell transplant therapy has been shown to be clinically feasible for the treatment of AMD and RP and the differentiation procedures to derive human retinal cells from hES cells have been worked out. We are working toward the manufacture of these cells for therapeutic use.

 

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According to a 2004 study on Blindness and Blinding Diseases in the U.S. published by the University of Washington, approximately 13,000,000 Americans have signs of AMD, over 10,000,000 suffer visual loss and over 200,000 are legally blind from the disease. The occurrence of AMD increases with a patient’s age. According to the same study, approximately 6,300,000 people are projected to develop AMD in 2030, compared to 1,700,000 in 1995.
Because the therapeutic use of retinal cells is one of the more advanced applications in stem cell therapy and we have already produced human retinal pigment epithelial cells from human embryonic stem cell lines, we are focusing on retinal cells as our first therapeutic market target. Our goal is to manufacture retinal cells derived from hES cells to replace the limited supply of donor derived cells for therapeutic use. We will collaborate with academic research and other research institutions to develop FDA-approved therapeutic methodologies for producing retinal cells for therapeutic use.
Diabetes — Another area of focus is on diabetes. According to the American Diabetes Association, approximately 20,800,000 people, or 7% of the U.S. population, have some form of diabetes, and the National Institutes of Health estimates that there are as many as 2,500,000 people suffering from Type 1 Diabetes (Insulin Dependent Diabetes Mellitus). Normally, certain cells in the pancreas, called the islet ß cells, produce insulin which promotes the uptake of the sugar glucose by cells in the human body. Degeneration of pancreatic islet ß cells results in a lack of insulin in the bloodstream which results in diabetes. Although diabetics can be treated with daily injections of insulin, these injections enable only intermittent glucose control.
The transplantation of insulin producing cells called “islet cells” from one person to another has been shown to relieve the suffering and serious side effects caused by current therapies. As the primary source of islet cells today is organ donations, available supply is extremely limited. Therefore, our objective in the field of diabetes therapy is to increase the availability of pancreatic islet cells by inducing stem cells derived from our parthenogenic cell lines to grow and become islets or the individual cells found in the islets.
Liver Disease — According to the American Liver Foundation, chronic liver disease (including hepatitis C) is the third most common cause of death due to chronic diseases in persons 35 to 64 years of age. In the United States diseases such as cirrhosis and hepatitis were ranked as the 12th leading cause of death in 2000. The only effective treatment currently available for people with liver failure is full or partial organ transplantation. Unfortunately, as with islets, the demand for organs far exceeds the number of organs available. According to the United Network for Organ Sharing, there are currently more than 17,000 persons on the wait list for a liver transplant.
Liver cell transplantation has been used in early stage clinical trials to treat patients with liver failure caused by acute or chronic disease and in patients with genetically caused metabolic defects. This therapy has proven to be especially useful as a “bridge” to keep patients alive until they can receive a whole liver transplant, as well as an alternative to whole-organ transplantation in specific cases. The procedure involves supplementing a patient’s liver function by injecting a donor’s liver cells (obtained from livers donated from brain dead, heart beating donors) into a patient’s liver or spleen where the liver cells remain and function. Our objective is to provide an alternate source of liver cells for the treatment of liver disease through cell transplant therapy.

 

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Research Market
The research market for cell systems is made up of scientists performing basic research and applied research in the biological sciences. Basic research involves the study of cell biology, and the biochemical pathways to human disease. Applied research involves drug discovery, vaccine development, clinical research including cell engineering, and cell transplantation.
The domestic market can be broken into three segments. These include: (i) academic researchers in universities and privately-funded research organizations; (ii) government institutions such as the National Institutes of Health, the U.S. Army, the U.S. Environmental Protection Agency and others; and (iii) industrial organizations such as pharmaceutical companies and consumer product companies. Management believes that the combined academic and government market comprises approximately 40% of the total market and that the industrial segment comprises approximately 60% of the remaining market.
We believe the following are the main drivers in the research market for commercial cell systems:
   
The need for experimental human cells which are more predictive of human biology than non-human cells or genetically modified cell lines.
   
The desire to lower the cost of drug development in the pharmaceutical industry. We believe that human cell systems may provide a platform for screening toxic drugs early in the development process, thus avoiding late stage failures in clinical trials and reducing costs.
   
The need to eliminate animal products in research reagents that may contaminate future therapeutic products.
   
The need for experimental control. Serum-free defined media provides the benefit of experimental control because there are fewer undefined components.
   
The need for consistency in experiments that can be given by quality controlled products.
   
The need to eliminate the necessity to formulate media in-house, obtain tissue or perform cell isolations.
   
The need to reduce animal testing in the consumer products industry.
Our internal projections for the global market for human cell systems for use in basic research are several hundred million dollars annually with an anticipated growth rate between 10% and 20%.

 

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INTELLECTUAL PROPERTY
Patents
We have filed patent applications covering our proprietary technology to create stem cells without the use of fertilized eggs or transferred DNA. In addition, we have obtained the exclusive worldwide licenses to a portfolio of patents and patent applications from Advanced Cell Technology.
Our patent portfolio consists of 30 families of patents consisting of over 130 separate patents (including international filings) and patent applications in the field of stem cell culture. We also have an exclusive license to the only patent issued by the U.S. Patent & Trademark Office for the creation of human embryonic stem cells, or hES cells using nuclear transfer technology for human therapeutic use. Of these, eight are issued patents and a majority of the patents and applications have been filed in the United States and in foreign countries through the Patent Corporation Treaty or by direct country filings in those jurisdictions deemed significant to our operations.
The patentability of human cells in countries throughout the world reflects widely differing governmental attitudes. In the United States, hundreds of patents covering human embryonic stem cells have already been granted, including those on which we rely. In certain countries in Europe, the European Patent Office currently appears to take the position that hES cells themselves are not patentable, while the United Kingdom has decided that some types of hES cells can be patented. As a result, we plan to file internationally wherever feasible and focus our research strategy on cells that best fit the United States and United Kingdom Patent Offices’ definitions of patentable cells.
License Agreements
In May 2005, we entered into three exclusive license agreements with Advanced Cell Technology for the production of therapeutic products in the fields of diabetes, liver disease, retinal disease, and the creation of research products in all fields. The license agreements give us access to all aspects of Advanced Cell Technology’s human cell patent portfolio as it existed on that date, plus a combination of exclusive and non-exclusive rights to future developments. A significant feature of the licensed technology is that it allows us to isolate and differentiate hES stem cells directly from a “blastocyst.” The hES cells can be immediately differentiated into stem cells capable of expansion and differentiation into islet cells, liver cells, and retinal cells.
Pursuant to the terms of our agreements with Advanced Cell Technology, in exchange for worldwide therapeutic rights to Advanced Cell Technology’s portfolio of patents and patent applications in the fields of diabetes, liver disease and retinal disease, we are required to make payments of $75,000 in May 2007, $112,500 in May 2008 and annual payments thereafter of $150,000, plus milestone payments linked to the launch of therapeutic products (not research products) ranging from $250,000 at first launch to $1 million upon reaching sales of $10 million, with a maximum of $1.75 million in the aggregate. The agreements also require us to pay royalties on sales and meet minimum research and development requirements. The agreements continue until expiration of the last valid claim within the licensed patent rights. Advanced Cell Technology is required to defend any patent infringement claims. Either party may terminate the agreements for an uncured breach, or we may terminate the agreements at any time with 30 days notice.

 

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The agreements with Advanced Cell Technology further provide that any technology either party currently owns, develops or licenses in the future will be licensed to the other party for use in their specific therapeutic field. This arrangement gives Advanced Cell Technology and us continuing access to future discoveries made or licensed by either party.
Exclusive License Agreement Number One, as amended , covers patent rights and technology that are relevant to:
   
the research, development, manufacture and sale of human and non-human animal cells for commercial research; and
   
the manufacture and selling of hES cells for therapeutic and diagnostic use in the treatment of human diabetes, liver diseases, retinal diseases and retinal degenerative diseases.
Exclusive License Agreement Number Two, as amended , covers patent rights and technology that are relevant to:
   
the research, development, manufacture and sale of human and non-human animal cells and defined animal cell lines for commercial research;
   
the manufacture and selling of human cells for therapeutic and diagnostic use in the treatment of human diabetes, liver diseases, retinal diseases and retinal degenerative diseases; and
   
the use of defined animal cell lines in the process of manufacturing and selling human cells for therapeutic and diagnostic use in the treatment of human diabetes, liver diseases and retinal diseases.
Exclusive License Agreement Number Three, as amended , covers patent rights and technology relevant to the research, development, manufacture and sale of human cells for cell therapy in the treatment of therapeutic and diagnostic use in the treatment of human diabetes and liver diseases, and retinal diseases and retinal degenerative diseases.
Research Agreements
Dr. Revazova, our Chief Scientist, is currently conducting basic research at the Scientific Center for Obstetrics, Gynecology and Perinatology of the Russian Academy of Medical Sciences in Moscow, Russia (the “Institute”). This laboratory contains all of the necessary equipment and scientific resources to complete our preliminary research in parthenogenesis and Somatic Cell Nuclear Transfer technology. Through a research agreement, Dr. Revazova continues to conduct research into the creation and characterization of embryonic stem cells. The Institute provides Dr. Revazova access to the equipment and technicians needed to create and fully characterize human parthenogenic and embryonic stem cells. This includes equipment for immunofluorescence, karyotyping, gene expression, and equipment for molecular biology and cell biology. In addition, through our relationship with the Institute, we have access to expert Russian scientists from the Russian Academy of Sciences. Under the terms of the agreement, we retain all intellectual property rights in the United States and the Institute retains such rights in Russia. We share equally in any royalty payments from the rest of the world, but we retain control of all marketing and distribution anywhere in the world, except Russia. This agreement expires at the end December 2006, and is expected to be renewed for an additional one year term prior to expiration.

 

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COMPETITION
The development of therapeutic and diagnostic agents for human disease is intensely competitive. Pharmaceutical companies currently offer a number of pharmaceutical products to treat diabetes, liver diseases, retinal disease and other diseases for which our technologies may be applicable. Many pharmaceutical and biotechnology companies are investigating new drugs and therapeutic approaches for the same purposes, which may achieve new efficacy profiles, extend the therapeutic window for such products, alter the prognosis of these diseases, or prevent their onset. We believe that our theraputic products, when and if successfully developed, will compete with these products principally on the basis of improved and extended efficacy and safety and their overall economic benefit to the health care system. We believe that our most significant competitors will be fully integrated pharmaceutical companies and more established biotechnology companies. Smaller companies may also be significant competitors, particularly through collaborative arrangements with large pharmaceutical or biotechnology companies. Some of our primary competitors in the development of stem cell therapies are Geron Corporation, Genzyme Corporation, StemCell Technologies Inc., Advanced Cell Technology, Aastrom Biosciences, Inc. and ViaCell, Inc., most of which have substantially greater resources and experience. In the field of research products, our primary competitors for stem cells, media and reagents are Chemicon, Invitrogen Corp., StemCell Technologies Inc. and Specialty Media. These companies primarily provide standard media that have not been optimized for human embryonic stem cell growth.
SALES AND MARKETING
To date, sales of our research products have been modest and derived primarily through word of mouth, but we intend to develop a sales force to market our research and our cell therapy and diagnostic products in the U.S. Because of the nature of the markets in which we participate, we believe that a modest size sales force will be sufficient. We also anticipate partnering with large biotech and pharmaceutical companies for the marketing and sales of some, but not necessarily all, of our stem cell based therapeutic products.
GOVERNMENT REGULATION
Regulation by governmental authorities in the United States and other countries is a significant factor in the development, manufacture and marketing of our proposed therapeutic products and in our ongoing research and product development activities. The nature and extent to which such regulation applies to us will vary depending on the nature of any products which may be developed by us. We anticipate that many, if not all, of our proposed products will require regulatory approval by governmental agencies prior to commercialization. In particular, human therapeutic products are subject to rigorous preclinical and clinical testing and other approval procedures of the FDA, and similar regulatory authorities in European and other countries. Various governmental statutes and regulations also govern or influence testing, manufacturing, safety, labeling, storage and recordkeeping related to such products and their marketing. The process of obtaining these approvals and the subsequent compliance with appropriate statutes and regulations require the expenditure of substantial time and money, and there can be no guarantee that approvals will be granted.

 

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FDA Approval Process
Prior to commencement of clinical studies involving humans, preclinical testing of new pharmaceutical products is generally conducted on animals in the laboratory to evaluate the potential efficacy and safety of the product candidate. The results of these studies are submitted to the FDA as a part of an Investigational New Drug (IND) application, which must become effective before clinical testing in humans can begin. Typically, human clinical evaluation involves a time-consuming and costly three-phase process. In Phase 1, clinical trials are conducted with a small number of people to assess safety and to evaluate the pattern of drug distribution and metabolism within the body. In Phase 2, clinical trials are conducted with groups of patients afflicted with a specific disease in order to determine preliminary efficacy, optimal dosages and expanded evidence of safety. In some cases, an initial trial is conducted in diseased patients to assess both preliminary efficacy and preliminary safety and patterns of drug metabolism and distribution, in which case it is referred to as a Phase 1-2 trial. In Phase 3, large-scale, multi-center, comparative trials are conducted with patients afflicted with a target disease in order to provide enough data to demonstrate the efficacy and safety required by the FDA. The FDA closely monitors the progress of each of the three phases of clinical testing and may, at its discretion, re-evaluate, alter, suspend, or terminate the testing based upon the data which have been accumulated to that point and its assessment of the risk/benefit ratio to the patient. Monitoring of all aspects of the study to minimize risks is a continuing process. All adverse events must be reported to the FDA.
The results of the preclinical and clinical testing on a non-biologic drug and certain diagnostic drugs are submitted to the FDA in the form of a New Drug Application (“NDA”) for approval prior to commencement of commercial sales. In the case of vaccines or gene and cell therapies, the results of clinical trials are submitted as a Biologics License Application (“BLA”). In responding to a NDA or BLA, the FDA may grant marketing approval, request additional information or refuse to approve if the FDA determines that the application does not satisfy its regulatory approval criteria. There can be no assurance that approvals will be granted on a timely basis, if at all, for any of our proposed products.
European and Other Regulatory Approval
Whether or not FDA approval has been obtained, approval of a product by comparable regulatory authorities in Europe and other countries will likely be necessary prior to commencement of marketing the product in such countries. The regulatory authorities in each country may impose their own requirements and may refuse to grant an approval, or may require additional data before granting it, even though the relevant product has been approved by the FDA or another authority. As with the FDA, the regulatory authorities in the European Union (“EU”) and other developed countries have lengthy approval processes for pharmaceutical products. The process for gaining approval in particular countries varies, but generally follows a similar sequence to that described for FDA approval. In Europe, the European Committee for Proprietary Medicinal Products provides a mechanism for EU-member states to exchange information on all aspects of product licensing. The EU has established a European agency for the evaluation of medical products, with both a centralized community procedure and a decentralized procedure, the latter being based on the principle of licensing within one member country followed by mutual recognition by the other member countries.

 

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Other Regulations
We are also subject to various United States federal, state, local and international laws, regulations and recommendations relating to safe working conditions, laboratory and manufacturing practices and the use and disposal of hazardous or potentially hazardous substances, including radioactive compounds and infectious disease agents, used in connection with our research work. We cannot accurately predict the extent of government regulation which might result from future legislation or administrative action.
PROPERTIES
We have established our primary research facility in 8,215 square feet of leased office and laboratory space in Oceanside, California. Our lease for this facility expires in August 2011, with a five year option to renew at our discretion. The facility has over $1,000,000 of improvements which include clean rooms, segregated rooms for biohazard control and containment of human donor tissue. We believe that this facility is well suited to meet our research and development needs.
We have a 3,240 square foot laboratory in Walkersville, Maryland. Our lease for this facility expires in March 2009, with a three year renewal option. This laboratory is being used to develop and manufacture our research products, as well as for sales and marketing and general administration. The Walkersville facility contains a 2,000 square foot manufacturing laboratory space with two clean rooms and is fitted with the necessary water purification, refrigeration, labeling equipment and standard manufacturing equipment to manufacture, package, store and distribute media products. There is a 500 square foot quality control and cell culture laboratory outfitted with the necessary cell isolation equipment, incubators, microscopes and standard cell culture equipment necessary to isolate and culture cells and conduct quality control tests to produce superior cell culture products. The manufacturing and quality control laboratories also serve as product development laboratories, and 300 square feet are devoted to administration, sales and marketing. This area contains the computers, communication equipment and the file systems necessary to establish technical offices, sales and marketing offices, finance and human resources. Equipment monitoring and security systems are in place.
EMPLOYEES
In addition to our four executive officers, we utilize the services of eight full-time and nine part-time staff members or consultants.

 

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RISK FACTORS
The following summarizes material risks relating to us that you should carefully consider. Any of the following risks, if they actually occur, would likely harm our business, financial condition and results of operations.
Our business is at an early stage of development and we may not develop products that can be commercialized.
Our business is at an early stage of development. We do not have any products in late-stage clinical trials. We are still in the early stages of identifying and conducting research on potential products. Our potential products will require significant research and development and preclinical and clinical testing prior to regulatory approval in the United States and other countries. We may not be able to obtain regulatory approvals, enter clinical trials for any of our product candidates, or commercialize any products. Our product candidates may prove to have undesirable and unintended side effects or other characteristics adversely affecting their safety, efficacy or cost-effectiveness that could prevent or limit their use. Any product using any of our technology may fail to provide the intended therapeutic benefits, or achieve therapeutic benefits equal to or better than the standard of treatment at the time of testing or production.
We have a history of operating losses and do not expect to be profitable in the near future.
We have not generated any profits since our entry into the biotechnology business and have incurred significant operating losses. We expect to incur additional operating losses for the foreseeable future and, as we increase our research and development activities, we expect our operating losses to increase significantly. We do not have any sources of significant revenues and may not have any in the foreseeable future.
We will need additional capital to conduct our operations and develop our products and our ability to obtain the necessary funding is uncertain.
We need to obtain significant additional capital resources from sources including equity and/or debt financings, license arrangements, grants and/or collaborative research arrangements in order to develop products. We believe that we have sufficient working capital to finance operations through the third quarter of 2008. Thereafter, we will need to raise additional working capital. Our current burn rate is approximately $250,000 per month excluding capital expenditures. The timing and degree of any future capital requirements will depend on many factors, including:
   
the accuracy of the assumptions underlying our estimates for capital needs in 2007 and beyond;
 
   
scientific progress in our research and development programs;
 
   
the magnitude and scope of our research and development programs and our ability to establish, enforce and maintain strategic arrangements for research, development, clinical testing, manufacturing and marketing;
 
   
our progress with preclinical development and clinical trials;

 

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the time and costs involved in obtaining regulatory approvals;
 
   
the costs involved in preparing, filing, prosecuting, maintaining, defending and enforcing patent claims; and
 
   
the number and type of product candidates that we pursue.
Additional financing through strategic collaborations, public or private equity financings or other financing sources may not be available on acceptable terms, or at all. Additional equity financing could result in significant dilution to our stockholders. Further, if additional funds are obtained through arrangements with collaborative partners, these arrangements may require us to relinquish rights to some of our technologies, product candidates or products that we would otherwise seek to develop and commercialize on our own. If sufficient capital is not available, we may be required to delay, reduce the scope of or eliminate one or more of our product lines, any of which could have a material adverse affect on our financial condition or business prospects.
Clinical trials are subject to extensive regulatory requirements, very expensive, time-consuming and difficult to design and implement. Our products may fail to achieve necessary safety and efficacy endpoints during clinical trials.
Human clinical trials can be very expensive and difficult to design and implement, in part because they are subject to rigorous regulatory requirements. The clinical trial process is also time consuming. We estimate that clinical trials of our product candidates will take at least several years to complete. Furthermore, failure can occur at any stage of the trials, and we could encounter problems that cause us to abandon or repeat clinical trials. The commencement and completion of clinical trials may be delayed by several factors, including:
   
unforeseen safety issues;
 
   
determination of dosing issues;
 
   
lack of effectiveness during clinical trials;
 
   
slower than expected rates of patient recruitment;
 
   
inability to monitor patients adequately during or after treatment; and
 
   
inability or unwillingness of medical investigators to follow our clinical protocols.
In addition, we or the FDA may suspend our clinical trials at any time if it appears that we are exposing participants to unacceptable health risks or if the FDA finds deficiencies in our IND submissions or the conduct of these trials.

 

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Patents obtained by other persons may result in infringement claims against us that are costly to defend and which may limit our ability to use the disputed technologies and prevent us from pursuing research and development or commercialization of potential products.
A number of pharmaceutical, biotechnology and other companies, universities and research institutions have filed patent applications or have been issued patents relating to cell therapy, stem cells, and other technologies potentially relevant to or required by our expected products. We cannot predict which, if any, of such applications will issue as patents or the claims that might be allowed. We are aware that a number of companies have filed applications relating to stem cells. We are also aware of a number of patent applications and patents claiming use of stem cells and other modified cells to treat disease, disorder or injury.
If third party patents or patent applications contain claims infringed by either our licensed technology or other technology required to make and use our potential products and such claims are ultimately determined to be valid, there can be no assurance that we would be able to obtain licenses to these patents at a reasonable cost, if at all, or be able to develop or obtain alternative technology. If we are unable to obtain such licenses at a reasonable cost, we may not be able to develop some products commercially. There can be no assurance that we will not be obliged to defend ourselves in court against allegations of infringement of third party patents. Patent litigation is very expensive and could consume substantial resources and create significant uncertainties. An adverse outcome in such a suit could subject us to significant liabilities to third parties, require disputed rights to be licensed from third parties, or require us to cease using such technology.
We may not be able to adequately protect against piracy of intellectual property in foreign jurisdictions.
Considerable research in the areas of stem cells, cell therapeutics and regenerative medicine is being performed in countries outside of the United States, and a number of our competitors are located in those countries. The laws protecting intellectual property in some of those countries may not provide adequate protection to prevent our competitors from misappropriating our intellectual property.
Our competition includes fully integrated biotechnology and pharmaceutical companies that have significant advantages over us.
The market for therapeutic stem cell products is highly competitive. We expect that our most significant competitors will be fully integrated pharmaceutical companies and more established biotechnology and stem cell companies. These companies are developing stem cell-based products and they have significantly greater capital resources in research and development, manufacturing, testing, obtaining regulatory approvals, and marketing capabilities. Many of these potential competitors are further along in the process of product development and also operate large, company-funded research and development programs. As a result, our competitors may develop more competitive or affordable products, or achieve earlier patent protection or product commercialization than we are able to achieve. Competitive products may render any products or product candidates that we develop obsolete.

 

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If we fail to meet our obligations under our license agreements, we may lose our rights to key technologies on which our business depends.
Our business depends in part on licenses from third parties. These third party license agreements impose obligations on us, such as payment obligations and obligations to diligently pursue development of commercial products under the licensed patents. If a licensor believes that we have failed to meet our obligations under a license agreement, the licensor could seek to limit or terminate our license rights, which could lead to costly and time-consuming litigation and, potentially, a loss of the licensed rights. During the period of any such litigation, our ability to carry out the development and commercialization of potential products could be significantly and negatively affected. If our license rights were restricted or ultimately lost, our ability to continue our business based on the affected technology platform could be severely adversely affected.
Restrictive and extensive government regulation could slow or hinder our production of a cellular product.
The research and development of stem cell therapies is subject to and restricted by extensive regulation by governmental authorities in the United States and other countries. The process of obtaining FDA and other necessary regulatory approvals is lengthy, expensive and uncertain. We may fail to obtain the necessary approvals to continue our research and development, which would hinder our ability to manufacture or market any future product.
Research in the field of nuclear transfer and embryonic stem cells is currently subject to strict government regulations, and our operations could be restricted or outlawed by any legislative or administrative efforts impacting the use of nuclear transfer technology or human embryonic material.
Our business is focused on human cell therapy, which includes the production of human differentiated cells from stem cells and involves human oocytes and may involve the use of nuclear transfer technology embryonic material. Nuclear transfer technology, commonly known as therapeutic cloning, and research utilizing embryonic stem cells is controversial, and currently subject to intense scrutiny, particularly in the area of nuclear transfer of human cells and the use of human embryonic material. Cloning for research purposes is unlawful in many states and this type of prohibition may expand into other states, including some where we now operate.
Although current federal law only restricts the use of federal funds for hES cell research, there can be no assurance that our operations will not be restricted by any future legislative or administrative efforts by politicians or groups opposed to the development of hES call technology or nuclear transfer technology, or that such efforts might not be extended to include our parthenogenic technology. Further, there can be no assurance that legislative or administrative restrictions directly or indirectly delaying, limiting or preventing the use of hES technology, nuclear transfer technology, the use of human embryonic material, or the sale, manufacture or use of products or services derived from nuclear transfer technology or other hES technology will not be adopted in the future or extend to include our parthenogenetic processes. For example, Senate bill S-658, which remains in committee and may or may not become law, has provisions in it which may be interpreted to prohibit the specific technology known as Somatic Nuclear Cell Transfer, the rights to which we have licensed.

 

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Restrictions on the use of human embryonic stem cells, and the ethical, legal and social implications of that research, could prevent us from developing or gaining acceptance for commercially viable products in these areas.
Although our stem cells are derived from unfertilized human eggs through a process that can produce cells suitable for therapy, but are believed to be incapable of producing a human being, such cells are nevertheless often referred to as “embryonic” stem cells. Because the use of human embryonic stem cells gives rise to ethical, legal and social issues regarding the appropriate use of these cells, our research related to human parthenogenic stem cells could become the subject of adverse commentary or publicity and some political and religious groups may still raise opposition to our technology and practices. In addition, many research institutions, including some of our scientific collaborators, have adopted policies regarding the ethical use of human embryonic tissue, which, if applied to our procedures, may have the effect of limiting the scope of research conducted using our stem cells, thereby impairing our ability to conduct research in this field. In some states, use of embryos as a source of stem cells is prohibited.
To the extent we utilize governmental grants in the future, the governmental entities involved may retain certain rights in technology that we develop using such grant money and we may lose the revenues from such technology if we do not commercialize and utilize the technology pursuant to established government guidelines.
Certain of our and our licensors’ research has been or is being funded in part by government grants. In connection with certain grants, the governmental entity involved retains rights in the technology developed with the grant. These rights could restrict our ability to fully capitalize upon the value of this research by reducing total revenues that might otherwise be available since such governmental rights may give it the right to practice the invention without payment of royalties.
We rely on parthenogenesis, cell differentiation and other stem cell technologies that we may not be able to successfully develop, which may prevent us from generating revenues, operating profitably or providing investors any return on their investment.
We have concentrated our research on our parthenogenesis, cell differentiation and stem cell technologies, and our ability to operate profitably will depend on being able to successfully implement or develop these technologies for human applications. These are emerging technologies with, as yet, limited human applications. We cannot guarantee that we will be able to successfully implement or develop our nuclear transfer, parthenogenesis, cell differentiation and other stem cell technologies or that these technologies will result in products or services with any significant commercial utility. We anticipate that the commercial sale of such products or services, and royalty/licensing fees related to our technology, would be our primary sources of revenues.

 

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The outcome of pre-clinical, clinical and product testing of our products is uncertain, and if we are unable to satisfactorily complete such testing, or if such testing yields unsatisfactory results, we will be unable to commercially produce our proposed products.
Before obtaining regulatory approvals for the commercial sale of any potential human products, our products will be subjected to extensive pre-clinical and clinical testing to demonstrate their safety and efficacy in humans. We cannot assure you that the clinical trials of our products, or those of our licensees or collaborators, will demonstrate the safety and efficacy of such products at all, or to the extent necessary to obtain appropriate regulatory approvals, or that the testing of such products will be completed in a timely manner, if at all, or without significant increases in costs, program delays or both, all of which could harm our ability to generate revenues. In addition, our prospective products may not prove to be more effective for treating disease or injury than current therapies. Accordingly, we may have to delay or abandon efforts to research, develop or obtain regulatory approval to market our prospective products. The failure to adequately demonstrate the safety and efficacy of a therapeutic product under development could delay or prevent regulatory approval of the product and could harm our ability to generate revenues, operate profitably or produce any return on an investment in us.
If we are unable to keep up with rapid technological changes in our field or compete effectively, we will be unable to operate profitably.
We are engaged in activities in the biotechnology field, which is characterized by extensive research efforts and rapid technological progress. If we fail to anticipate or respond adequately to technological developments, our ability to operate profitably could suffer. We cannot assure you that research and discoveries by other biotechnology, agricultural, pharmaceutical or other companies will not render our technologies or potential products or services uneconomical or result in products superior to those we develop or that any technologies, products or services we develop will be preferred to any existing or newly-developed technologies, products or services.
We may not be able to protect our proprietary technology, which could harm our ability to operate profitably.
The biotechnology and pharmaceutical industries place considerable importance on obtaining patent and trade secret protection for new technologies, products and processes. Our success will depend, to a substantial degree, on our ability to obtain and enforce patent protection for our products, preserve any trade secrets and operate without infringing the proprietary rights of others. We cannot assure you that:
   
we will succeed in obtaining any patents, obtain them in a timely manner, or that the breadth or degree of protection that any such patents will protect our interests;
   
the use of our technology will not infringe on the proprietary rights of others;
   
patent applications relating to our potential products or technologies will result in the issuance of any patents or that, if issued, such patents will afford adequate protection to us or will not be challenged, invalidated or infringed; or
   
patents will not be issued to other parties, which may be infringed by our potential products or technologies.

 

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We are aware of certain patents that have been granted to others and certain patent applications that have been filed by others with respect to nuclear transfer and other stem cell technologies. The fields in which we operate have been characterized by significant efforts by competitors to establish dominant or blocking patent rights to gain a competitive advantage, and by considerable differences of opinion as to the value and legal legitimacy of competitors’ purported patent rights and the technologies they actually utilize in their businesses.
Our business is highly dependent upon maintaining licenses with respect to key technology.
Many of the key patents we utilize are licensed to us by Advanced Cell Technology, which has licensed some of these from other parties, including the University of Massachusetts. These licenses are subject to termination under certain circumstances (including, for example, our failure to make minimum royalty payments or to timely achieve development and commercialization benchmarks). The loss of any of such licenses, or the conversion of such licenses to non-exclusive licenses, could harm our operations and/or enhance the prospects of our competitors. Although our licenses with Advanced Cell Technology allow us to cure any defaults under the underlying licenses to them and to take over the patents and patents pending in the event of default by Advanced Cell Technology, the cost of such remedies could be significant and we might be unable to adequately maintain these patent positions. If so, such inability could have a material adverse affect on our business.
Certain of such licenses also contain restrictions ( e.g. , limitations on our ability to grant sublicenses) that could materially interfere with our ability to generate revenue through the licensing or sale to third parties of important and valuable technologies that we have, for strategic reasons, elected not to pursue directly. The possibility exists that in the future we will require further licenses to complete and/or commercialize our proposed products. There can be no assurance that we will be able to acquire any such licenses on a commercially viable basis.
Certain of our technology is not protectable by patent which leaves us vulnerable to theft of our technology.
Certain parts of our know-how and technology are not patentable. To protect our proprietary position in such know-how and technology, we intend to require all employees, consultants, advisors and collaborators to enter into confidentiality and invention ownership agreements with us. There can be no assurance, however, that these agreements will provide meaningful protection for our trade secrets, know-how or other proprietary information in the event of any unauthorized use or disclosure. Further, in the absence of patent protection, competitors who independently develop substantially equivalent technology may harm our business.
We depend on our collaborators to help us develop and test our proposed products, and our ability to develop and commercialize products may be impaired or delayed if collaborations are unsuccessful.
Our strategy for the development, clinical testing and commercialization of our proposed products requires that we enter into collaborations with corporate partners, licensors, licensees and others. We are dependent upon the subsequent success of these other parties in performing their respective responsibilities and the continued cooperation of our partners. Our collaborators may not cooperate with us or perform their obligations under our agreements with them. We cannot control the amount and timing of our collaborators’ resources that will be devoted to our research and development activities related to our collaborative agreements with them. Our collaborators may choose to pursue existing or alternative technologies in preference to those being developed in collaboration with us.

 

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Under agreements with collaborators, we may rely significantly on such collaborators to, among other things:
   
design and conduct advanced clinical trials in the event that we reach clinical trials;
   
fund research and development activities with us;
   
pay us fees upon the achievement of milestones; and
   
market with us any commercial products that result from our collaborations.
The development and commercialization of potential products will be delayed if collaborators fail to conduct these activities in a timely manner, or at all. In addition, our collaborators could terminate their agreements with us and we may not receive any development or milestone payments. If we do not achieve milestones set forth in the agreements, or if our collaborators breach or terminate their collaborative agreements with us, our business may be materially harmed.
Our reliance on the activities of our non-employee consultants, research institutions, and scientific contractors, whose activities are not wholly within our control, may lead to delays in development of our proposed products.
We rely extensively upon and have relationships with scientific consultants at academic and other institutions, some of whom conduct research at our request, and other consultants with expertise in clinical development strategy or other matters. These consultants are not our employees and may have commitments to, or consulting or advisory contracts with, other entities that may limit their availability to us. We have limited control over the activities of these consultants and, except as otherwise required by our collaboration and consulting agreements to the extent they exist, can expect only limited amounts of their time to be dedicated to our activities.
These research facilities may have commitments to other commercial and non-commercial entities. We have limited control over the operations of these laboratories and can expect only limited amounts of time to be dedicated to our research goals.
We may be subject to litigation that will be costly to defend or pursue and uncertain in its outcome.
Our business may bring us into conflict with our licensees, licensors or others with whom we have contractual or other business relationships, or with our competitors or others whose interests differ from ours. If we are unable to resolve those conflicts on terms that are satisfactory to all parties, we may become involved in litigation brought by or against us. That litigation is likely to be expensive and may require a significant amount of management’s time and attention, at the expense of other aspects of our business. The outcome of litigation is always uncertain, and in some cases could include judgments against us that require us to pay damages, enjoin us from certain activities, or otherwise affect our legal or contractual rights, which could have a significant adverse effect on our business.

 

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We may not be able to obtain third-party patient reimbursement or favorable product pricing, which would reduce our ability to operate profitably.
Our ability to successfully commercialize certain of our proposed products in the human therapeutic field may depend to a significant degree on patient reimbursement of the costs of such products and related treatments at acceptable levels from government authorities, private health insurers and other organizations, such as health maintenance organizations. We cannot assure you that reimbursement in the United States or foreign countries will be available for any products we may develop or, if available, will not be decreased in the future, or that reimbursement amounts will not reduce the demand for, or the price of, our products with a consequent harm to our business. We cannot predict what additional regulation or legislation relating to the health care industry or third-party coverage and reimbursement may be enacted in the future or what effect such regulation or legislation may have on our business. If additional regulations are overly onerous or expensive, or if health care related legislation makes our business more expensive or burdensome than originally anticipated, we may be forced to significantly downsize our business plans or completely abandon our business model.
Our products may be expensive to manufacture, and they may not be profitable if we are unable to control the costs to manufacture them.
Our products may be significantly more expensive to manufacture than other therapeutic products currently on the market today. We hope to substantially reduce manufacturing costs through process improvements, development of new science, increases in manufacturing scale and outsourcing to experienced manufacturers. If we are not able to make these, or other improvements, and depending on the pricing of the product, our profit margins may be significantly less than that of most therapeutic products on the market today. In addition, we may not be able to charge a high enough price for any cell therapy product we develop, even if they are safe and effective, to make a profit. If we are unable to realize significant profits from our potential product candidates, our business would be materially harmed.
To be successful, our proposed products must be accepted by the health care community, which can be very slow to adopt or unreceptive to new technologies and products.
Our proposed products and those developed by our collaborative partners, if approved for marketing, may not achieve market acceptance since hospitals, physicians, patients or the medical community in general may decide not to accept and utilize these products. The products that we are attempting to develop represent substantial departures from established treatment methods and will compete with a number of more conventional therapies manufactured and marketed by major pharmaceutical companies. The degree of market acceptance of any of our developed products will depend on a number of factors, including:
   
our establishment and demonstration to the medical community of the clinical efficacy and safety of our proposed products;

 

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our ability to create products that are superior to alternatives currently on the market;
   
our ability to establish in the medical community the potential advantage of our treatments over alternative treatment methods; and
   
reimbursement policies of government and third-party payors.
If the healthcare community does not accept our products for any of the foregoing reasons, or for any other reason, our business would be materially harmed.
We depend on key personnel for our continued operations and future success, and a loss of certain key personnel could significantly hinder our ability to move forward with our business plan.
Because of the specialized nature of our business, we are highly dependent on our ability to identify, hire, train and retain highly qualified scientific and technical personnel for the research and development activities we conduct or sponsor. The loss of one or more key executive officers, or scientific officers, particularly Mr. Krstich, Mr. Janus and Dr. Revazova, would be significantly detrimental to us. In addition, recruiting and retaining qualified scientific personnel to perform research and development work is critical to our success. Our anticipated growth and expansion into areas and activities requiring additional expertise, such as clinical testing, regulatory compliance, manufacturing and marketing, will require the addition of new management personnel and the development of additional expertise by existing management personnel. There is intense competition for qualified personnel in the areas of our present and planned activities, and there can be no assurance that we will be able to continue to attract and retain the qualified personnel necessary for the development of our business. The failure to attract and retain such personnel or to develop such expertise would adversely affect our business.
We may have no product liability insurance, which may leave us vulnerable to future claims we will be unable to satisfy.
The testing, manufacturing, marketing and sale of human therapeutic products entail an inherent risk of product liability claims, and we cannot assure you that substantial product liability claims will not be asserted against us. In the event we are forced to expend significant funds on defending product liability actions, and in the event those funds come from operating capital, we will be required to reduce our business activities, which could lead to significant losses. We cannot assure you that adequate insurance coverage will be available in the future on acceptable terms, if at all, or that, if available, we will be able to maintain any such insurance at sufficient levels of coverage or that any such insurance will provide adequate protection against potential liabilities. Whether or not a product liability insurance policy is obtained or maintained in the future, any product liability claim could harm our business or financial condition.
The sale or issuance of a substantial number of shares may adversely affect the market price for BTHC Common Stock.
The future sale of a substantial number of shares of BTHC Common Stock in the public market, or the perception that such sales could occur, could significantly and negatively affect the market price for BTHC Common Stock. We expect that we will likely issue a substantial number of shares of our capital stock in financing transactions in order to fund our operations and the growth of our business. Under these arrangements, we may agree to register the shares for resale soon after their issuance. We may also continue to pay for certain goods and services with equity, which would dilute our current stockholders. Also, sales of the shares issued in this manner could negatively affect the market price of our stock.

 

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We do not intend to pay cash dividends on BTHC Common Stock in the foreseeable future.
Any payment of cash dividends will depend upon our financial condition, results of operations, capital requirements and other factors and will be at the discretion of the Board of Directors. We do not anticipate paying cash dividends on BTHC Common Stock in the foreseeable future. Furthermore, we may incur additional indebtedness that may severely restrict or prohibit the payment of dividends.
Limitations on director and officer liability and indemnification of our officers and directors by us may discourage stockholders from bringing suit against a director.
Our certificate of incorporation and bylaws provide, with certain exceptions as permitted by governing state law, that a director or officer shall not be personally liable to us or our stockholders for breach of fiduciary duty as a director, except for acts or omissions which involve intentional misconduct, fraud or knowing violation of law, or unlawful payments of dividends. These provisions may discourage stockholders from bringing suit against a director for breach of fiduciary duty and may reduce the likelihood of derivative litigation brought by stockholders on our behalf against a director. In addition, our certificate of incorporation and bylaws may provide for mandatory indemnification of directors and officers to the fullest extent permitted by governing state law.
Stock prices for biotechnology companies have historically tended to be very volatile.
Stock prices and trading volumes for many biotechnology companies fluctuate widely for a number of reasons, including but not limited to the following factors, some of which may be unrelated to their businesses or results of operations:
   
clinical trial results;
   
the amount of cash resources and such company’s ability to obtain additional funding;
   
announcements of research activities, business developments, technological innovations or new products by competitors;
   
entering into or terminating strategic relationships;
   
changes in government regulation;
   
disputes concerning patents or proprietary rights;
   
changes in our revenues or expense levels;
   
public concern regarding the safety, efficacy or other aspects of the products or methodologies we are developing;

 

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reports by securities analysts;
   
activities of various interest groups or organizations;
   
media coverage; and
   
status of the investment markets.
This market volatility, as well as general domestic or international economic, market and political conditions, could materially and adversely affect the market price of BTHC Common Stock.
The application of the “penny stock” rules to BTHC Common Stock could limit the trading and liquidity of the BTHC Common Stock, adversely affect the market price of BTHC Common Stock and increase stockholder transaction costs to sell those shares.
As long as the trading price of BTHC Common Stock is below $5.00 per share, the open-market trading of BTHC Common Stock will be subject to the “penny stock” rules, unless we otherwise qualify for an exemption from the “penny stock” definition. The “penny stock” rules impose additional sales practice requirements on certain broker-dealers who sell securities to persons other than established customers and accredited investors (generally those with assets in excess of $1,000,000 or annual income exceeding $200,000 or $300,000 together with their spouse). These regulations, if they apply, require the delivery, prior to any transaction involving a penny stock, of a disclosure schedule explaining the penny stock market and the associated risks. Under these regulations, certain brokers who recommend such securities to persons other than established customers or certain accredited investors must make a special written suitability determination regarding such a purchaser and receive such purchaser’s written agreement to a transaction prior to sale. These regulations may have the effect of limiting the trading activity of BTHC Common Stock, reducing the liquidity of an investment in BTHC Common Stock and increasing the transaction costs for sales and purchases of BTHC Common Stock as compared to other securities.
The market price for BTHC Common Stock may be particularly volatile given our status as a relatively unknown company with a limited operating history and lack of profits which could lead to wide fluctuations in our share price. The price at which stockholders purchase shares of BTHC Common Stock may not be indicative of the price of the BTHC Common Stock that will prevail in the trading market.
The market for BTHC Common Stock may be characterized by significant price volatility when compared to seasoned issuers, and we expect that our stock price could continue to be more volatile than a seasoned issuer for the indefinite future. The potential volatility in our share price is attributable to a number of factors. First, there has been no trading in BTHC Common Stock. As a consequence of this lack of liquidity, any future trading of shares by our stockholders may disproportionately influence the price of those shares in either direction. Second, we are a speculative or “risky” investment due to our limited operating history and lack of profits to date, and uncertainty of future market acceptance for our potential products. As a consequence of this enhanced risk, more risk averse investors may, under the fear of losing all or most of their investment in the event of negative news or lack of progress, be more inclined to sell their shares on the market more quickly and at greater discounts than would be the case with the stock of a seasoned issuer. Many of these factors will be beyond our control and may decrease the market price of BTHC Common Stock, regardless of our operating performance. We cannot make any predictions or projections as to what the prevailing market price for BTHC Common Stock will be at any time or as to what effect that the sale of shares or the availability of shares for sale at any time will have on the prevailing market price.

 

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In addition, the market price of BTHC Common Stock could be subject to wide fluctuations in response to:
   
quarterly variations in our revenues and operating expenses;
   
announcements of new products or services by us;
   
fluctuations in interest rates;
   
significant sales of BTHC Common Stock;
   
the operating and stock price performance of other companies that investors may deem comparable to us; and
   
news reports relating to trends in our markets or general economic conditions.
CAUTIONARY LANGUAGE REGARDING FORWARD-LOOKING STATEMENTS AND INDUSTRY DATA
This Current Report on Form 8-K contains “forward-looking statements” that involve risks and uncertainties, many of which are beyond the Registrant’s control. The Registrant’s actual results could differ materially and adversely from those anticipated in such forward-looking statements as a result of certain factors, including those set forth below and elsewhere in this Current Report on Form 8-K. Important factors that may cause actual results to differ include:
   
adverse economic conditions;
   
inability to raise sufficient additional capital to operate our business;
   
unexpected costs and operating deficits, and lower than expected sales and revenues;
   
adverse results of any legal proceedings;
   
inability to procure the key components of our products or the failure to obtain acceptable quality key components on a cost-effective basis;
   
the volatility of our operating results and financial condition;
   
inability to attract or retain qualified senior management personnel, including research and development personnel; and
   
other specific risks that may be alluded to in this Current Report on Form 8-K.

 

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All statements, other than statements of historical facts, included in this Current Report on Form 8-K regarding the Registrant’s strategy, future operations, financial position, estimated revenue or losses, projected costs, prospects and plans and objectives of management are forward-looking statements. When used in this Current Report on Form 8-K, the words “will,” “may,” “believe,” “anticipate,” “intend,” “estimate,” “expect,” “project,” “plan” and similar expressions are intended to identify forward-looking statements, although not all forward-looking statements contain such identifying words. All forward-looking statements speak only as of the date of this Current Report on Form 8-K.
MANAGEMENT’S DISCUSSION AND ANALYSIS OR PLAN OF OPERATION
The following discussion of our financial condition and results of operations should be read in conjunction with our financial statements and related notes included under Item 9.01(a) of this Current Report on Form 8-K. The information in this Current Report Form 8-K contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. All statements other than statements of historical fact made in this registration statement are forward looking. In particular, the statements herein regarding industry prospects and future results of operations or financial position are forward-looking statements. Forward-looking statements reflect management’s current expectations and are inherently uncertain. Our actual results may differ significantly from management’s expectations. This discussion should not be construed to imply that the results discussed herein will necessarily continue into the future, or that any conclusion reached herein will necessarily be indicative of actual operating results in the future. Such discussion represents only the best present assessment of our management.
BTHC III, Inc. was incorporated on June 7, 2005 as a Delaware corporation to effect the reincorporation of BTHC III, LLC, a Texas limited liability company, mandated by a plan of reorganization which is included in the Form 10-SB filed with the SEC on May 24, 2006. In accordance with the confirmed plan of reorganization on December 28, 2006, pursuant to the terms of the Exchange Agreement, BTHC acquired all of the outstanding capital stock of ISC. The Share Exchange is accounted for herein as a reverse merger. In the Share Exchange, BTHC is considered the legal acquirer and ISC is considered the accounting acquirer. ISC was incorporated on June 16, 2006 as a California corporation to effect the reorganization of Lifeline Technology, LLC, a California limited liability company. As a result of the reorganization, Lifeline is the wholly-owned subsidiary of ISC.
As ISC is considered the account acquirer, we have included in this Current Report Form 8-K the financial statements of ISC for the period of inception to the nine-months ended September 30, 2006 and the financial statements of Lifeline, which was the operating company until the incorporation of ISC, for the fiscal years ended December 31, 2004 and 2005 and for the nine-month periods ended September 30, 2005 and September 30, 2006. The financial results of operation discussed below are those of ISC and Lifeline.
RESULTS OF OPERATIONS
For the years ended December 31, 2005 and December 31, 2004
Revenues
Lifeline is a development stage company and has generated nominal revenues, none in the year ended December 31, 2004 and $158 during the year ended December 31, 2005.

 

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General and Administrative Expenses
General and administrative expenses were $461,634 for the year ended December 31, 2005 as compared to $197,579 for the preceding year. The primary reason for the increase was Lifeline’s continued expansion over the past year. Increases in consulting fees in the year ended December 31, 2005 over the previous year of $58,729, in legal and accounting fees of $69,086, and patent license fees of $37,500 accounted for most of the increase.
Research and Development
Research and development expenses were $804,191 for the year ended December 31, 2005 as compared to $585,494 for the preceding year. The increase was the result of expanded research and development operations. The staffing cost for Lifeline’s commitments under the research agreement in Russia increased by $163,051 and consulting increased by $32,379, for a total increase of $195,430 in 2005 over 2004.
Other
Other expenses increased slightly to $82,870 for the year ended December 31, 2005 as compared to $68,682 for the preceding year most of which was the result of a $26,000 increase from the imputed interest on the $400,000 note payable.
For the nine months ended September 30, 2006 and September 30, 2005
Revenues
Lifeline is a development stage company and has generated nominal revenues, none in the nine months ended September 30, 2005 and $1,745 during the nine months ended September 30, 2006.
General and Administrative Expenses
General and administrative expenses were $1,584,729 for the nine months ended September 30, 2006 as compared to $309,920 for the nine months ended September 30, 2005. The growth of Lifeline accounted for the increased cost in 2006 over 2005, including warrants issued for services of $808,000, consulting fees increases of $101,000 for investment banking services, the establishment of the office in Oceanside, legal fees of $56,000, and professional fees of $72,000 relating mainly to the first audit and to recruiting fees.
Research and Development
Research and development expenses were $735,499 for the nine months ended September 30, 2006 as compared to $540,303 for the nine months ended September 30, 2005. The primary reasons for the greater expenditure were increased patent license fees of $75,000 and payroll and payroll costs of $83,000.

 

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Other
Other expenses increased to $204,704 for the nine months ended September 30, 2006 as compared to $52,119 for the nine months ended September 30, 2005, most of which was the result of a $55,000 increase in interest expense due to imputed interest on the $400,000 note payable and a $93,000 charge resulting from a settlement with American Stem Cell.
LIQUIDITY AND CAPITAL RESOURCES
ISC raised $11,205,950 in the ISC Private Placement. Management believes that there is sufficient working capital to finance operations through the third quarter of 2008, however, significant additional capital resources are required from sources including equity and/or debt financings, license arrangements, grants and/or collaborative research arrangements in order to develop products. Thereafter, additional working capital will need to be raised. The current burn rate is approximately $250,000 per month excluding capital expenditures. The timing and degree of any future capital requirements will depend on many factors, including:
   
the accuracy of the assumptions underlying our estimates for capital needs in 2007 and beyond;
 
   
scientific progress in our research and development programs;
 
   
the magnitude and scope of our research and development programs and our ability to establish, enforce and maintain strategic arrangements for research, development, clinical testing, manufacturing and marketing;
 
   
our progress with preclinical development and clinical trials;
 
   
the time and costs involved in obtaining regulatory approvals;
 
   
the costs involved in preparing, filing, prosecuting, maintaining, defending and enforcing patent claims; and
 
   
the number and type of product candidates that we pursue.
Additional financing through strategic collaborations, public or private equity financings or other financing sources may not be available on acceptable terms, or at all. Additional equity financing could result in significant dilution to our stockholders. Further, if additional funds are obtained through arrangements with collaborative partners, these arrangements may require us to relinquish rights to some of our technologies, product candidates or products that we would otherwise seek to develop and commercialize on our own. If sufficient capital is not available, we may be required to delay, reduce the scope of or eliminate one or more of our product lines.
CRITICAL ACCOUNTING POLICIES
The financial statements have been prepared in accordance with accounting principles generally accepted in the United States of America. The preparation of these financial statements requires management to make estimates and assumptions that affect the reported amounts of assets, liabilities, revenues and expenses. Note 1 of the Notes to Financial Statements describes the significant accounting policies used in the preparation of the financial statements. Certain of these significant accounting policies are considered to be critical accounting policies, as defined below.

 

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A critical accounting policy is defined as one that is both material to the presentation of our financial statements and requires management to make difficult, subjective or complex judgments that could have a material effect on our financial condition and results of operations. Specifically, critical accounting estimates have the following attributes: (1) we are required to make assumptions about matters that are highly uncertain at the time of the estimate; and (2) different estimates we could reasonably have used, or changes in the estimate that are reasonably likely to occur, would have a material effect on our financial condition or results of operations.
Estimates and assumptions about future events and their effects cannot be determined with certainty. We base our estimates on our limited historical experience and on various other assumptions believed to be applicable and reasonable under the circumstances. These estimates may change as new events occur, as additional information is obtained and as our operating environment changes. As we have recently begun operations we have not had any changes, but would include any changes in the financial statements as soon as they became known. Based on a critical assessment of our accounting policies and the underlying judgments and uncertainties affecting the application of those policies, management believes that our financial statements are fairly stated in accordance with accounting principles generally accepted in the United States, and present a meaningful presentation of our financial condition and results of operations. We believe the following critical accounting policies reflect our more significant estimates and assumptions used in the preparation of our financial statements:
Use of Estimates
These financial statements have been prepared in accordance with accounting principles generally accepted in the United States and, accordingly, require management to make estimates and assumptions that affect the reported amounts of assets and liabilities at the date of the financial statements and the reported amounts of revenues and expenses during the reporting period. Actual results could differ from those estimates.
Cash Equivalents
The company considers all highly liquid investments with a maturity of three months or less when purchased to be cash equivalents.
Short-Term Investments
Management determines the appropriate classification of marketable securities at the time of purchase, and has classified all short-term investments as available-for-sale. Such securities are stated at fair value, with the unrealized gains and losses reported as a separate component of equity. Fair value is determined based on quoted market prices.
Property and Equipment
Property and equipment are stated at cost. The provision for depreciation and amortization is computed using the straight-line method over the estimated useful lives of the assets, which generally range from three to five years. The costs of major remodeling and leasehold improvements are capitalized and depreciated over the shorter of the remaining term of the lease or the life of the asset.

 

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Long-Lived Asset Impairment
We review long-lived assets for impairment when events or changes in business conditions indicate that their carrying value may not be recovered. We consider assets to be impaired and write them down to fair value if expected associated cash flows are less than the carrying amounts. Fair value is the present value of the associated cash flows. We have determined that no material long-lived assets are impaired at September 30, 2006.
Recent Accounting Pronouncements
In October 2006, the Emerging Issues Task Force (“EITF”) issued EITF 06-3, “How Taxes Collected from Customers and Remitted to Governmental Authorities Should Be Presented in the Income Statement (That is, Gross versus Net Presentation)” to clarify diversity in practice on the presentation of different types of taxes in the financial statements. EITF concluded that, for taxes within the scope of the issue, a company may adopt a policy of presenting taxes either gross within revenue or net. That is, it may include charges to customers for taxes within revenues and the charge for the taxes from the taxing authority within cost of sales, or, alternatively, it may net the charge to the customer and the charge from the taxing authority. If taxes subject to EITF 06-3 are significant, a company is required to disclose its accounting policy for presenting taxes and the amounts of such taxes that are recognized on a gross basis. The guidance in this consensus is effective for the first interim reporting period beginning after December 15, 2006 (the first quarter of our fiscal year 2007). We do not expect the adoption of EITF 06-3 will have a material impact on our results of operations, financial position or cash flow.
In September 2006, the SEC issued Staff Accounting Bulletin No. 108, “Considering the Effects of Prior Year Misstatements when Quantifying Misstatements in Current Year Financial Statements” (“SAB 108”). SAB 108 provides guidance on the consideration of the effects of prior year misstatements in quantifying current year misstatements for the purpose of a materiality assessment. SAB 108 establishes an approach that requires quantification of financial statement errors based on the effects on each of the company’s balance sheets, statements of operations and related financial statement disclosures. SAB 108 permits existing public companies to record the cumulative effect of initially applying this approach in the first year ending after November 15, 2006 by recording the necessary correcting adjustments to the carrying values of assets and liabilities as of the beginning of that year with the offsetting adjustment recorded to the opening balance of retained earnings. Additionally, the use of the cumulative effect transition method requires detailed disclosure of the nature and amount of each individual error being corrected through the cumulative adjustment and how and when it arose. The company is currently evaluating the impact SAB 108 may have on its results of operations and financial condition.

 

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In September 2006, the Financial Accounting Standards Board (the “FASB”) issued SFAS No. 158, “Employer’s accounting for Defined Benefit Pension and Other Post Retirement Plans”. SFAS No. 158 requires employers to recognize in its statement of financial position an asset or liability based on the retirement plan’s over or under funded status. SFAS No. 158 is effective for fiscal years ending after December 15, 2006. The company is currently evaluating the effect that the application of SFAS No. 158 will have on its results of operations and financial condition.
In September 2006, the FASB issued SFAS No. 157, “Fair Value Measurements”, which defines the fair value, establishes a framework for measuring fair value and expands disclosures about fair value measurements. This statement is effective for financial statements issued for fiscal years beginning after November 15, 2007, and interim periods within those fiscal years. Early adoption is encouraged, provided that the company has not yet issued financial statements for that fiscal year, including any financial statements for an interim period within that fiscal year. The company is currently evaluating the impact SFAS 157 may have on its financial condition or results of operations.
In July 2006, the FASB released FASB Interpretation No. 48, Accounting for Uncertainty in Income Taxes, an interpretation of FASB Statement No. 109 (“FIN 48”). FIN 48 clarifies the accounting and reporting for uncertainties in income tax law. This interpretation prescribes a comprehensive model for the financial statement recognition, measurement, presentation and disclosure of uncertain tax positions taken or expected to be taken in income tax returns. This statement is effective for fiscal years beginning after December 15, 2006. The company is currently evaluating the impact FIN 48 may have on its financial condition or results of operations.
In March 2006, the FASB issued SFAS No. 156, “Accounting for Servicing of Financial Assets”, which provides an approach to simplify efforts to obtain hedge-like (offset) accounting. SFAS No. 156 amends FASB Statement No. 140, “Accounting for Transfers and Servicing of Financial Assets and Extinguishments of Liabilities”, with respect to the accounting for separately recognized servicing assets and servicing liabilities. SFAS No. 156 (1) requires an entity to recognize a servicing asset or servicing liability each time it undertakes an obligation to service a financial asset by entering into a servicing contract in certain situations; (2) requires that a separately recognized servicing asset or servicing liability be initially measured at fair value, if practicable; (3) permits an entity to choose either the amortization method or the fair value method for subsequent measurement for each class of separately recognized servicing assets or servicing liabilities; (4) permits at initial adoption a one-time reclassification of available-for-sale securities to trading securities by an entity with recognized servicing rights, provided the securities reclassified offset the entity’s exposure to changes in the fair value of the servicing assets or liabilities; and (5) requires separate presentation of servicing assets and servicing liabilities subsequently measured at fair value in the balance sheet and additional disclosures for all separately recognized servicing assets and servicing liabilities. SFAS No. 156 is effective for all separately recognized servicing assets and liabilities as of the beginning of an entity’s fiscal year that begins after September 15, 2006, with earlier adoption permitted in certain circumstances. SFAS No. 156 also describes the manner in which it should be initially applied. The company does not believe that SFAS No. 156 will have a material impact on its financial position, results of operations or cash flows.

 

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In February 2006, the FASB issued SFAS No. 155, “Accounting for Certain Hybrid Financial Instruments”, which amends SFAS No. 133, “Accounting for Derivatives Instruments and Hedging Activities” and SFAS No. 140, “Accounting for Transfers and Servicing of Financial Assets and Extinguishment of Liabilities”. SFAS No. 155 amends SFAS No. 133 to narrow the scope exception for interest-only and principal-only strips on debt instruments to include only such strips representing rights to receive a specified portion of the contractual interest or principle cash flows. SFAS No. 155 also amends SFAS No. 140 to allow qualifying special-purpose entities to hold a passive derivative financial instrument pertaining to beneficial interests that itself is a derivative instrument. The company is currently evaluating SFAS No. 155 but cannot determine the future impact as the company does not have any “ Derivatives Instruments and Hedging Activities”, but may implement them in the future.
In November 2005, the FASB issued FSP FAS 115-1 and FAS 124-1, “The Meaning of Other-Than-Temporary Impairment and Its Application to Certain Investments”, which clarifies when an investment is considered impaired, whether the impairment is other-than-temporary, and the measurement of an impairment loss. It also includes accounting considerations subsequent to the recognition of the other-than-temporary impairment and requires certain disclosures about unrealized losses that have not been recognized as other-than-temporary impairments. FSP 115-1 and 124-1 are effective for all reporting periods beginning after December 15, 2005. The company does not anticipate that the implementation of these statements will have a significant impact on its financial position, results of operations or cash flows.
In May 2005, the FASB issued SFAS No. 154, “Accounting Changes and Error Corrections”. SFAS No. 154 is a replacement of Accounting Principles Board Opinion No. 20 and SFAS No. 3. SFAS No. 154 provides guidance on the accounting for and reporting of accounting changes and error corrections. It establishes retrospective application as the required method for reporting a change in accounting principle. SFAS No. 154 provides guidance for determining whether retrospective application of a change in accounting principle is impracticable and for reporting a change when retrospective application is impracticable. SFAS No. 154 also addresses the reporting of a correction of an error by restating previously issued financial statements. SFAS No 154 is effective for accounting changes and corrections of errors made in fiscal years beginning after December 15, 2005. The company does not believe that it will have a material impact on its financial position, results of operations or cash flows.
In December 2004, the FASB issued SFAS No. 153, “Exchanges of Nonmonetary Assets, an amendment of APB Opinion No. 29, Accounting for Nonmonetary Transactions.” The amendments made by SFAS No. 153 are based on the principle that exchanges of nonmonetary assets should be measured based on the fair value of the assets exchanged. Further, the amendments eliminate the narrow exception for nonmonetary exchanges of similar productive assets and replace it with a broader exception for exchanges of nonmonetary assets that do not have commercial substance. Previously, Opinion 29 required that the accounting for an exchange of a productive asset for a similar productive asset or an equivalent interest in the same or similar productive asset should be based on the recorded amount of the asset relinquished. Opinion 29 provided an exception to its basic measurement principle (fair value) for exchanges of similar productive assets. The FASB believes that exception required that some nonmonetary exchanges, although commercially substantive, be recorded on a carryover basis. By focusing the exception on exchanges that lack commercial substance, the FASB believes this statement produces financial reporting that more faithfully represents the economics of the transactions. SFAS No. 153 is effective for nonmonetary asset exchanges occurring in fiscal periods beginning after June 15, 2005. Earlier application is permitted for nonmonetary asset exchanges occurring in fiscal periods beginning after the date of issuance. The provisions of SFAS No. 153 shall be applied prospectively. The company has evaluated the impact of the adoption of SFAS No. 153, and does not believe the impact will be significant to the company’s overall results of operations or financial position.

 

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In December 2004, the FASB issued SFAS No. 123 (revised 2004), “Share-Based Payment”. SFAS 123(R) will provide investors and other users of financial statements with more complete and neutral financial information by requiring that the compensation cost relating to share-based payment transactions be recognized in financial statements. That cost will be measured based on the fair value of the equity or liability instruments issued. SFAS 123(R) covers a wide range of share-based compensation arrangements including share options, restricted share plans, performance-based awards, share appreciation rights, and employee share purchase plans. SFAS 123(R) replaces FASB Statement No. 123, “Accounting for Stock-Based Compensation”, and supersedes APB Opinion No. 25, “Accounting for Stock Issued to Employees”. SFAS 123, as originally issued in 1995, established as preferable a fair-value-based method of accounting for share-based payment transactions with employees. However, that statement permitted entities the option of continuing to apply the guidance in Opinion 25, as long as the footnotes to financial statements disclosed what net income would have been had the preferable fair-value-based method been used. Public entities (other than those filing as small business issuers) will be required to apply SFAS 123(R) as of the first interim or annual reporting period that begins after June 15, 2005. SFAS 123(R) is applicable for ASC effective the first interim period that starts after July 1, 2005. The company has evaluated the impact of the adoption of SFAS 123(R), and cannot determine the future impact as the company does not have any “Share Based Payment” compensations programs, but may implement them in the future.
In November 2004, the FASB issued SFAS No. 151, “Inventory Costs, an amendment of ARB No. 43, Chapter 4”. The amendments made by SFAS No. 151 clarify that abnormal amounts of idle facility expense, freight, handling costs, and wasted materials (spoilage) should be recognized as current period charges and require the allocation of fixed production overheads to inventory based on the normal capacity of the production facilities. The guidance is effective for inventory costs incurred during fiscal years beginning after June 15, 2005. Earlier application is permitted for inventory costs incurred during fiscal years beginning after November 23, 2004. The company has evaluated the impact of the adoption of SFAS No. 151, and does not believe the impact will be significant to the company’s overall results of operations or financial position since the company does not currently have any manufacturing operations or inventory.
In March 2004, the FASB approved the consensus reached on the EITF Issue No. 03-1, “The Meaning of Other-Than-Temporary Impairment and Its Application to Certain Investments.” The objective of EITF 03-1 is to provide guidance for identifying impaired investments. EITF 03-1 also provides new disclosure requirements for investments that are deemed to be temporarily impaired. The accounting provisions of EITF 03-1 are effective for all reporting periods beginning after June 15, 2004, while the disclosure requirements for certain investments are effective for annual periods ending after December 15, 2003, and for other investments such disclosure requirements are effective for annual periods ending after June 15, 2004.

 

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In December 2003, the SEC issued SAB No. 104, “Revenue Recognition.” SAB No. 104 supersedes SAB No. 101, “Revenue Recognition in Financial Statements.” SAB No. 104, which was effective upon issuance, rescinded certain guidance contained in SAB No. 101 related to multiple element revenue arrangements, and replaced such guidance with that contained in EITF 00-21, “Accounting for Revenue Arrangements with Multiple Deliverables.” Additionally, SAB No. 104 rescinded the SEC’s Revenue Recognition in Financial Statements Frequently Asked Questions and Answers issued with SAB No. 101. The revenue recognition principles of SAB No. 101 remain largely unchanged by the issuance of SAB No. 104, and therefore the adoption of SAB No. 104 did not have a material effect on the company’s results of operations or financial condition.
In January 2003, the FASB issued FIN 46, “Consolidation of Variable Interest Entities”. In December 2003, FIN 46 was replaced by FIN 46(R) “Consolidation of Variable Interest Entities.” FIN 46(R) clarifies the application of Accounting Research Bulletin No. 51, “Consolidated Financial Statements,” to certain entities in which equity investors do not have the characteristics of a controlling financial interest or do not have sufficient equity at risk for the entity to finance its activities without additional subordinated financial support from other parties. FIN 46(R) requires an enterprise to consolidate a variable interest entity if that enterprise will absorb a majority of the entity’s expected losses, is entitled to receive a majority of the entity’s expected residual returns, or both. FIN 46(R) is effective for entities being evaluated under FIN 46(R) for consolidation no later than the end of the first reporting period that ends after March 15, 2004. The company does not currently have any variable interest entities that will be impacted by adoption of FIN 46(R).
SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENT
The following table sets forth information regarding the beneficial ownership of BTHC Common Stock as of December 28, 2006, by (i) each person who is known by us to beneficially own 5% or more of BTHC Common Stock, (ii) each of our directors and executive officers, and (iii) all executive officers and directors as a group. In general, a person is deemed to be a “beneficial owner” of a security if that person has or shares the power to vote or direct the voting of such security, or the power to dispose or to direct the disposition of such security. A person is also deemed to be a beneficial owner of any securities of which the person has the right to acquire beneficial ownership within 60 days. To the best of our knowledge, all persons named have sole voting and investment power with respect to such shares, except as otherwise noted. Unless otherwise specified, the address for each of the following persons is 2595 Jason Court, Oceanside, CA 92056.

 

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    Amount of     Percent of  
    Beneficial     Beneficial  
Name of Beneficial Owner   Ownership     Ownership (1)  
Directors and Officers:
               
Jeff Krstich — Chief Executive Officer (2)
    136,000       *  
William B. Adams — Chief Financial Officer (3)
    2,116,685       6.20 %
Kenneth C. Aldrich — Chairman (4)
    3,166,132       9.24 %
Jeffrey Janus — President and CEO of Lifeline Cell Technology (4)
    2,160,807       6.39 %
Timothy P. Halter (5)(6)
    1,547,000       4.53 %
Halter Financial Investments, LP (7)
    1,547,000       4.53 %
5% Holders:
               
Gregory Keller (8)
    2,377,179       6.99 %
William Peeples (9)
    2,779,174       8.17 %
All Executive Officers and Directors as a group (5 persons)
    8,972,624       22.23 %
 
*  
Less than 1%.
 
(1)  
Based on 35,321,495 shares currently outstanding plus shares issuable under derivative securities which are exercisable within 60 days of the date hereof.
 
(2)  
Includes options to purchase up to 136,000 shares of BTHC Common Stock under options exercisable within 60 days of this filing. Mr. Krstich also holds options to purchase an additional 900,000 shares which are not currently exercisable.
 
(3)  
Includes options to purchase up to 106,000 shares of BTHC Common Stock under options exercisable within 60 days of this filing.
 
(4)  
Mr. Aldrich’s shares are held, in part, through YKA Partners, a California limited partnership. Mr. Aldrich is the investment manager of YKA Partners and controls the disposition of these shares. The address for YKA Partners is 157 Surfview Drive, Pacific Palisades, CA 90272.
 
(5)  
Mr. Halter is a director. He also is a member of Halter Financial Investments, GP, LLC, the general partner of Halter Financial Investments L.P. Mr. Halter’s address is 12890 Hilltop Road, Argyle, TX 76226.
 
(6)  
Mr. Halter is deemed to beneficially own the shares owned by Halter Financial Investments, L.P.
 
(7)  
Halter Financial Investments, L.P.’s address is 12890 Hilltop Road, Argyle, TX 76226.
 
(8)  
The address for Mr. Keller is 771 Via Manana, Santa Barbara, CA, 93108.
 
(9)  
The address for Mr. Peeples is 877 Gwyne Ave., Santa Barbara, CA 93111.
DIRECTORS AND EXECUTIVE OFFICERS, PROMOTERS AND CONTROL PERSONS
The names, ages and positions of our directors and executive officers as of December 28, 2006, are as follows:
             
Name   Age   Position
Kenneth C. Aldrich
    68     Chairman of the Board
Jeff Krstich
    58     Chief Executive Officer
Jeffrey Janus
    50     President and Chief Executive Officer of Lifeline Cell Technology, LLC
William B. Adams
    63     Chief Financial Officer
Timothy Halter
    40     Director

 

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Officers and Directors
Kenneth C. Aldrich , our Chairman of the Board of Directors and a Co-Founder of International Stem Cell, joined the predecessor to International Stem Cell at its formation in 2001. He has been active in venture capital investing and private equity since 1975. He began his career as an attorney with the Los Angeles-based firm of O’Melveny & Myers in 1965. Mr. Aldrich then worked in the investment banking and real estate businesses until 1975.
Mr. Aldrich is currently Managing Director of Convergent Ventures, an early-stage life sciences investment company. Through that entity and predecessor companies, he has provided early-stage funding for a variety of biomedical and technology start-ups, including WaveTec Vision Systems, an ophthalmic device company (as Director and CEO), Neurion Pharmaceuticals, Inc., a drug discovery and evaluation company (as Director and co-founder), and Orfid Corporation, a developer of organic transistors (as a founder and financial advisor). He is also an active member of Tech Coast Angels and a director of Next Estate Communications, the world’s largest issuer of prepaid debit cards. Mr. Aldrich holds degrees, with honors, from both Harvard University and Harvard Law School.
Jeff Krstich , our Chief Executive Officer, joined International Stem Cell in early 2006. Previously he had been a senior executive in the healthcare industry for over 30 years with experience in Biotech, Diagnostics and Medical Device companies. From 2003 until joining International Stem Cell in 2006, he was Senior Vice President of Pathology Partners Inc., a medical products company, and was involved in the recapitalization and sale of that company to CARIS Ltd. From 2002 to 2003 he was President of MarketStar HealthCare, a subsidiary of Omnicom (NYSE: OMC). Prior to that he was Director of Sales at Biogen (Nasdaq: BIIB), a biotechnology company, where he served from 1996 to 2002. A former Navy Test Pilot and veteran of Vietnam and Gulf Storm, he has M.B.A. and a B.S. degree in engineering from the United States Naval Academy.
Jeffrey Janus , has been the President of International Stem Cell and the Chief Executive Officer of Lifeline, ISC’s wholly-owned subsidiary since 2003. He has over 16 years of experience commercializing human cell-based products for research use. Mr. Janus was one of the early founders of the Clonetics Ò brand of human cell systems, the world’s leading commercial line of human cell culture products. Clonetics was acquired by BioWhitaker, which was subsequently acquired by Cambrex Corporation (Rutherford, NJ). Mr. Janus served Clonetics and its successor companies from 1989 to 2002 coordinating in-house teams of research scientists, product managers and outside collaborators to develop and launch over 40 human cell systems consisting of over 200 individual products.

 

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William B. Adams , our Chief Financial Officer, is a Certified Public Accountant who joined Lifeline as a founder at its inception in 2001. He previously served in the accounting firm of Ernst & Ernst from 1966 to 1973. He co-founded Dimensional Planning Group, Inc., a management planning company in 1973 and was Vice President until 1976. From 1976 until present he formed and owns WB Adams Accountancy Corporation. Mr. Adams graduated with a BS from California State University Long Beach. He is on the Ernst & Young alumni board in Los Angeles and is also on the board of the Los Angeles Area Council of the Boy Scouts of America.
Timothy Halter, since 1995, Mr. Halter has been the president and the sole stockholder of Halter Financial Group, Inc. (“HFI”), a Dallas, Texas based consulting firm specializing in the area of mergers, acquisitions and corporate finance. In September 2006, Mr. Halter and other minority partners formed HFI. HFI conducts no business operations. Mr. Halter currently serves as a director of DXP Enterprises, Inc., a public corporation (Nasdaq: DXPE), and is an officer and director of Nevstar Corporation, a Nevada corporation, Robcor Properties, Inc., a Florida corporation, and Bronze Marketing, Inc., a Nevada corporation.
Key Employees
Elena Revazova, Ph.D.,. M.D. , our Chief Scientist, has worked for us since 2001 and, from 1998 to 2001, at the offices of one of our co-founders at the Keller Facial Surgery Clinic, Santa Barbara California. Prior to then, from 1992 to 1997, she was the Head of the Department of Experimental Models, Institute of Experimental and Clinical Oncology, Academy of Medical Science in Moscow, Russia; and from 1975 to 1991, she was a Senior Research Scientist in the Department of Experimental Models, Institute of Experimental and Clinical Oncology, Academy of Medical Science in Moscow Russia.
Dr. Revazova is one of the world’s experts in creating immortal cell lines without the introduction of cancer-causing factors and has written or co-authored over 57 patents in the field and for 22 heirs administered a collection of over 150 different cell lines. She has personally created or supervised the creation and patenting of over 50 different cell models that include stomach, colon, liver, renal, lung, muscle and skin cells and has also created stable human cell lines from tumors of various organs and tissues, including the esophagus, stomach, colon, liver, lung, larynx, uterus and breast. Since coming to the United States, Dr. Revazova has created approximately 40 human cell lines and several animal lines.
Jeremy Hammond , our Director of Quality Control, heads our efforts in the areas of product development, quality control and manufacturing scale-up within regulatory guidelines for cell culture products. He has over 20 years of direct experience in developing human cell-based products including serum-containing and serum-free media formulations and purified human cells. He has expertise in the culture of human embryonic stem cells and methods of cell manufacturing.
Hoyt Matthai , our Director of Manufacturing, has over 20 years of experience and knowledge directing and establishing manufacturing facilities and operations for the production of cell culture products and medical devices for pharmaceutical, in vitro diagnostic and research use. Mr. Matthai is using his experience to establish our manufacturing operations and control systems (documentation and environmental) needed for both research grade and therapeutic grade products. Mr. Matthai has previously been the Director of Manufacturing at the American Type Tissue Culture, the primary cell repository for the U.S. Government.

 

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Alexa Dillberger is our Director of Sales and Marketing. Ms. Dillberger has spent the last 25 years leading large pharmaceutical companies and biotech start-ups to bring the highest quality products to market. Ms. Dillberger led Technical Sales for Cambrex, formerly Clonetics, for over 11 years managing national accounts, negotiating contracts and developing the marketing programs for these leading cell-based companies. Ms. Dillberger holds a B.S. degree in Biochemistry, with a minor in Microbiology, from California Polytechnic University.
Scientific Advisors
Gregory S. Keller, M.D. , a Co-Founder and Scientific Advisor, is Co-Director of Facial Plastic Surgery, Division of Head and Neck Surgery at the University of California, Los Angeles. He has been involved in medical product development and applications for 26 years, and holds numerous patents on emerging medical technologies that have successfully transitioned to active medical products. Dr. Keller has been involved in cell technologies and their applications for the past ten years.
Hans S. Keirstead, Ph.D. , our Principal Independent Scientific Advisor, is one of the leaders in the development of stem cell therapy and will be guiding International Stem Cell’s retinal studies. Canadian-born neuroscientist Dr. Keirstead received his Ph.D. from the University of British Columbia in Vancouver, Canada and in 2000, Dr. Keirstead became an Assistant Professor in the Reeve-Irvine Research Center at the University of California, Irvine. The Reeve-Irvine Research Center, founded by actor Christopher Reeve and philanthropist Joan Irvine, is a leading center for spinal cord injury research. Dr. Keirstead directs a 20-person research team investigating the cellular biology and treatment of spinal cord trauma, research that also has significance for multiple sclerosis and other diseases of the nervous system.
Bernard M. Wagner, M.D. , a Scientific Advisor, is an Emeritus Research Professor of Pathology, New York University Medical Center and Emeritus Clinical Professor of Pathology, College of Physicians & Surgeons, Columbia University, New York. He is a Diplomat of the American Board of Pathology and Diplomat (Hon.), of the American College of Veterinary Pathologists. Dr. Wagner is also a Fellow of the Royal College of Pathologists (London); Fellow, Academy of Toxicologic Sciences; Fellow, New York Academy of Medicine; Member, Committee of Toxicology, National Academy of Sciences; Qualified Expert, European Council, Safety Assessment; Member Executive Committee, Board of Directors, American Registry of Pathology, Armed Forces Institute of Pathology; Member, GRAS Expert Panel (FDA); and Fellow of American Academy of Arts and Sciences. Currently, he is a senior consultant for Roche and consultant for ICOS Corp.
Michael Karas, M.D., Ph.D, M.B.A. , a Scientific Advisor, received his M.D. degree from Russian State Medical University in Moscow in 1985. In Russia, he worked on physiology of adaptation to extreme conditions such as high altitude. In 1991, he immigrated to Israel, where he earned a Ph.D. in biochemistry on signal transduction of insulin-like growth factors. Dr. Karas moved to the United States in 1997, and joined the Diabetes Branch of the National Institute of Diabetes and digestive and Kidney Diseases as a research fellow. In 2000, he joined Cambrex Corp., where he led the Cell Engineering Group. In 2004, after earning his M.B.A. in Finance from John Hopkins University, Dr. Karas joined the agrochemical division of FMC Corporation, where he is leading the program of developing novel platform technologies for the delivery of active ingredients.

 

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Employment Agreements
International Stem Cell has entered into employment agreements with Messrs. Krstich, Janus, Adams and Aldrich. Under the terms of these employment agreements, Messrs. Krstich and Janus have agreed to devote their full time and attention, and Messrs. Adams and Aldrich have agreed to devote substantially all of their time and attention, to the business of ISC. The employment agreements contain covenants (i) restricting the executive from engaging in any activities competitive with the business of ISC, (ii) prohibiting the executive from disclosing confidential information regarding ISC and (iii) requiring that all intellectual property developed by the executive and relating to the business of ISC constitutes the sole and exclusive property of ISC. After completion of the Share Exchange, the Board of Directors intends to review these employment agreements and determine whether to enter into new employment agreements with such executives. In addition, it is expected that similar employment contracts will be entered into with other key, executive and non-executive personnel as determined by the BTHC Board of Directors.
The foregoing description of the employment agreements does not purport to be complete and is qualified in its entirety by references to the employment agreements, which are attached hereto as Exhibits 10.1, 10.2, 10.3 and 10.4 and incorporated by reference.
Nominating Covenant
There is an obligation, for a period of two year period ending on November 7, 2007, if so requested by the placement agent in the ISC Private Placement, to nominate and use its best efforts to elect a designee of the placement agent acting on behalf of the investors, who is independent and has relevant business experience, to serve on the Registrant’s Board of Directors and as a member of either its Audit or Compensation Committee, or, at the option of the placement agent, as a non-voting adviser to the Registrant’s Board of Directors. The Registrant’s officers, directors and principal stockholders have agreed to vote their shares of BTHC Common Stock in favor of such designee. As of the date of this Current Report on Form 8-K, the Placement Agent has not yet exercised its right to designate such a person.
Board Committees
The Registrant presently does not have an audit committee, compensation committee or nominating committee or committee performing similar functions, as the management of the Registrant believes that until this point it has been premature at the early stage of the Registrant’s management and business development to form an audit, compensation or nominating committee. However, the new management of the Registrant plans to form audit, compensation and nominating committees in the near future. The Registrant envisions that the audit committee will be primarily responsible for reviewing the services performed by the Registrant’s independent auditors and evaluating its accounting policies and system of internal controls. The Registrant envisions that the compensation committee will be primarily responsible for reviewing and approving the Registrant’s salary and benefits policies (including stock options) and other compensation of the Registrant’s executive officers. Until these committees are established, these decisions will continue to be made by the Board of Directors. Although the Board of Directors has not established any minimum qualifications for director candidates, when considering potential director candidates, the Board of Directors considers the candidate’s character, judgment, skills and experience in the context of the needs of the Registrant and the Board of Directors.

 

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The Registrant does not have an audit committee charter or a charter governing the nominating process. Other than Mr. Halter, the members of the Board of Directors, who perform the functions of a nominating committee, are not independent because they are also officers of the Registrant. The determination of independence of directors has been made using the definition of “independent director” contained under Rule 4200(a)(15) of the Rules of National Association of Securities Dealers. There has not been any defined policy or procedure requirements for stockholders to submit recommendations or nomination for directors. The Board of Directors does not believe that a defined policy with regard to the consideration of candidates recommended by stockholders is necessary at this time because, given the early stages of the Registrant’s development, a specific nominating policy would be premature and of little assistance until the Registrant’s business operations are at a more advanced level.
The Board of Directors does not currently provide a process for shareholders to send communications to the Board of Directors because management of the Registrant believes that until this point it has been premature to develop such a process given the limited liquidity of the common stock of the Registrant. However, the new management of the Registrant may establish a process for shareholder communications in the future.
Indebtedness of Directors and Executive Officers
None of our directors or executive officers or their respective associates or affiliates is indebted to us.
Family Relationships
There are no family relationships among our directors and executive officers.
Legal Proceedings
As of the date of this Current Report on Form 8-K, there is no material proceeding to which any of our directors, executive officers, affiliates or stockholders is a party adverse to us.

 

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INTERNATIONAL STEM CELL CORPORATION 2006 EQUITY PARTICIPATION PLAN
Background
Effective as of November 17, 2006, the Board of Directors of International Stem Cell unanimously approved the International Stem Cell Corporation 2006 Equity Participation Plan (the “Participation Plan”), pursuant to which 15,000,000 shares of BTHC Common Stock are reserved for issuance under the Participation Plan. The purpose of the Participation Plan is to enable the Registrant to offer directors, officers and other key employees and consultants of the Registrant and its subsidiaries and affiliates equity-based compensation, thereby attracting, retaining, and rewarding these participants and strengthening the mutuality of interests between these participants and the Registrant’s stockholders. The Participation Plan permits the Registrant to keep pace with changing developments in management compensation and make the Registrant competitive with those companies that offer stock incentives to attract and retain directors and key employees. After approval and adoption by the Board of Directors of International Stem Cell, the Participation Plan was approved by the shareholders of International Stem Cell. The approval by the shareholders of International Stem Cell of the Participation Plan permits stock options and awards restricted by certain performance criteria as described below to qualify for deductibility under Section 162(m) of the Internal Revenue Code of 1986, as amended (the “Internal Revenue Code”).
A summary of the principal features of the Participation Plan is provided below, but is qualified in its entirety by reference to the full text of the Participation Plan that is attached to this Current Report on Form 8-K as Exhibit 10.15.
Shares Available
The Participation Plan reserves 15,000,000 shares of BTHC Common Stock for awards, subject to the adjustments described below. If there is a lapse, expiration, termination, or cancellation of any option or right prior to the issuance of shares or the payment of the equivalent thereunder, or if shares are issued and thereafter are reacquired by the Registrant pursuant to rights reserved upon issuance thereof, with respect to the Participation Plan, those shares may again be used for new awards under the Participation Plan. The Registrant will deduct any shares exchanged by an optionee in payment of the exercise price of any stock option, or any shares retained by the Registrant pursuant to a participant’s tax withholding election, from the shares available under the Participation Plan.
Administration
The Participation Plan is administered by the Registrant’s Board of Directors or any Committee of the Board of Directors to which the Board of Directors has delegated any responsibility for the implementation, interpretation or administration of the Participation Plan (the “Administrator”). Members of the Administrator will satisfy requirements under Rule 16b-3 under the Exchange Act, The Nasdaq Stock Market and the Internal Revenue Service with respect to plans intending to be qualified under Section 162(m) of the Internal Revenue Code by the end of the transition period applicable to newly public companies. Among the Administrator’s powers are the authority to construe and interpret the Participation Plan, establish rules, regulations, policies and procedures for its operation, select directors, officers and other key employees and consultants of the Registrant and its subsidiaries and affiliates to receive awards, and determine the form, amount, and other terms and conditions of awards. The Administrator also has the power to modify or waive restrictions on awards, to amend awards, and to grant extensions and accelerations of awards.

 

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Eligibility of Participation
Directors, officers and other key employees and consultants of the Registrant or any of its affiliates are eligible to participate in the Participation Plan. The selection of eligible participants is within the discretion of the Administrator. The estimated number of individuals who are currently eligible to participate in the Participation Plan is approximately 23, among directors, officers, other employees and consultants of the Registrant and its affiliates.
Types of Awards
The Participation Plan provides for the grant of stock options, including incentive stock options and non-qualified stock options, restricted stock and other equity-based awards.
Awards may be granted singly, in combination, or in tandem, as determined by the Administrator. The Board of Directors may amend or terminate the Participation Plan at any time, except as limited by the terms of the Participation Plan.
Stock Option Grants
The Administrator may grant options qualifying as incentive stock options under the Internal Revenue Code and nonqualified stock options. The term of an option will be fixed by the Administrator, but will not exceed ten years (or five years in the case of an incentive stock option granted to a person beneficially owning shares representing 10% or more of the total combined voting power of all classes of stock of the Registrant, referred to as a 10% stockholder). The option price for any option will not be less than the fair market value of BTHC Common Stock on the date of grant (or 110% of the fair market value in the case of an incentive stock option granted to a 10% stockholder). Generally, the fair market value will be the closing price of the BTHC Common Stock on the applicable trading market. Payment for shares purchased upon exercise of a stock option must be made in full at the time of purchase. Payment may be made (i) in cash; (ii) in a cash equivalent acceptable to the Administrator; (iii) by the transfer to the Registrant of shares owned by the participant for at least six months on the date of transfer; (iv) with a full-recourse promissory note until such time as the Registrant has a class of equity securities registered under Section 12 of the Securities Act; (v) if the BTHC Common Stock is traded on an established securities market, the Administrator may approve payment of the exercise price by a broker-dealer or by the option holder with cash advanced by the broker-dealer if the exercise notice is accompanied by the option holder’s written irrevocable instructions to deliver the BTHC Common Stock acquired upon exercise of the option to the broker-dealer; or (vi) any other method acceptable to the Administrator and in compliance with applicable laws.

 

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Restricted Stock
The Administrator is authorized to grant restricted stock. Restricted stock is a grant of shares of BTHC Common Stock which may not be sold or disposed of and which shall be subject to such risks of forfeiture and other restrictions as the Administrator may impose. Unless otherwise determined by the Administrator, the purchase price for any restricted stock grant will be 85% of the fair market value of BTHC Common Stock on the date of grant or at the time the purchase is consummated (or 100% of the fair market value in the case of restricted stock granted to a 10% stockholder). Generally, the fair market value will be the closing price of the BTHC Common Stock on the applicable trading market. Payment for shares purchased pursuant to a restricted stock grant may be made in (i) cash at the time of purchase; (ii) at the discretion of the Administrator, according to a deferred payment or other similar arrangement with the participant; or (iii) in any other form of legal consideration that may be acceptable to the Administrator in its discretion. A participant granted restricted stock generally has all of the rights of a stockholder of the Registrant, unless otherwise determined by the Administrator.
Maximum Awards
No employee may receive in any calendar year awards relating to more than 5,000,000 shares. This limitation applies following the date on which the Registrant has a class of equity securities registered under Section 12 of the Securities Act and upon the earlier of (i) a material modification of the Participation Plan; (ii) the first meeting of stockholders at which directors are elected and which occurs after the close of the third calendar year following the calendar year during which occurs the first registration of the Registrant’s equity securities under Section 12 of the Securities Act; and (iii) such date as is required to comply with Section 162(m) of the Internal Revenue Code and regulations thereunder.
Adjustments
The number and class of shares available under the Participation Plan and the terms of outstanding awards may be adjusted by the Administrator to prevent dilution or enlargement of rights in the event of various changes in the capitalization of the Registrant. The Administrator will, as it deems appropriate and equitable, have the right to:
   
proportionately adjust the number and types of shares of BTHC Common Stock (or other securities), exercise price, or performance standards of any or all benefits; and
   
make provision for a cash payment, acceleration or for substitution or exchange of any or all stock options, in connection with any extraordinary dividend or distribution, reclassification, recapitalization, stock split, reverse stock split, reorganization, merger, combination, consolidation, split-up, spin-off, combination, repurchase or exchange of BTHC Common Stock or securities of the Registrant, or similar, unusual or extraordinary corporate transaction or a sale of substantially all of the assets of the Registrant.

 

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Amendment of the Participation Plan
The Board of Directors has the right and power to amend the Participation Plan, without the consent of the participants. However, the Board of Directors may not amend the Participation Plan in a manner which would impair or adversely affect the rights of the holder of an award without the holder’s consent. The Registrant will obtain stockholder approval if (i) the amendment increases the number of shares reserved under the Participation Plan; (ii) the amendment increases the maximum amount of shares that may be subject to awards to a participant in a year; (iii) if the amendment changes the class of employees eligible to receive Incentive Stock Options; or (iv) if the Internal Revenue Code or any other applicable statute, rule or regulation, including, but not limited to, those of any securities exchange, requires shareholder approval with respect to the Participation Plan or the amendment.
Termination of the Participation Plan
The Participation Plan may be terminated at any time by the Board of Directors. Termination will not in any manner impair or adversely affect any benefit outstanding at the time of termination. The Participation Plan will expire on the earliest to occur of: (i) November 17, 2016; (ii) the date on which all shares available for issuance under the Participation Plan have been issued as fully vested shares; or (ii) the date determined by the Board pursuant to its authority under the Participation Plan.
Administrator’s Right to Modify Benefits
Any stock option granted may be converted, modified, forfeited, or canceled, in whole or in part, by the Administrator if and to the extent permitted in the Participation Plan, or applicable agreement entered into in connection with an award or with the consent of the participant to whom the award was granted.
Federal Tax Treatment
The Participation Plan is not qualified under the provisions of section 401(a) of the Internal Revenue Code and is not subject to any of the provisions of the Employee Retirement Income Security Act of 1974.
Nonqualified Stock Options
On exercise of a nonqualified stock option granted under the Participation Plan, an optionee will recognize ordinary income equal to the excess, if any, of the fair market value on the date of exercise of the shares of stock acquired on exercise of the option over the exercise price. If the optionee is an employee of the Registrant, that income will be subject to the withholding of Federal income tax. The optionee’s tax basis in those shares will be equal to their fair market value on the date of exercise of the option, and his holding period for those shares will begin on that date.
If an optionee pays for shares of stock on exercise of an option by delivering shares of BTHC Common Stock, the optionee will not recognize gain or loss on the shares delivered, even if their fair market value at the time of exercise differs from the optionee’s tax basis in them. The optionee, however, otherwise will be taxed on the exercise of the option in the manner described above as if he had paid the exercise price in cash. If a separate identifiable stock certificate is issued for that number of shares equal to the number of shares delivered on exercise of the option, the optionee’s tax basis in the shares represented by that certificate will be equal to his tax basis in the shares delivered, and his holding period for those shares will include his holding period for the shares delivered. The optionee’s tax basis and holding period for the additional shares received on exercise of the option will be the same as if the optionee had exercised the option solely in exchange for cash.

 

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The Registrant will be entitled to a deduction for Federal income tax purposes equal to the amount of ordinary income taxable to the optionee, provided that amount constitutes an ordinary and necessary business expense for the Registrant and is reasonable in amount, and either the employee includes that amount in income or the Registrant timely satisfies its reporting requirements with respect to that amount.
Incentive Stock Options
The Participation Plan provides for the grant of stock options that qualify as “incentive stock options” as defined in section 422 of the Internal Revenue Code. Under the Internal Revenue Code, an optionee generally is not subject to tax upon the grant or exercise of an incentive stock option. In addition, if the optionee holds a share received on exercise of an incentive stock option for at least two years from the date the option was granted and at least one year from the date the option was exercised, which we refer to as the Required Holding Period, the difference, if any, between the amount realized on a sale or other taxable disposition of that share and the holder’s tax basis in that share will be long-term capital gain or loss.
If, however, an optionee disposes of a share acquired on exercise of an incentive stock option before the end of the Required Holding Period, which we refer to as a Disqualifying Disposition, the optionee generally will recognize ordinary income in the year of the Disqualifying Disposition equal to the excess, if any, of the fair market value of the share on the date the incentive stock option was exercised over the exercise price. If, however, the Disqualifying Disposition is a sale or exchange on which a loss, if realized, would be recognized for Federal income tax purposes, and if the sales proceeds are less than the fair market value of the share on the date of exercise of the option, the amount of ordinary income recognized by the optionee will not exceed the gain, if any, realized on the sale. If the amount realized on a Disqualifying Disposition exceeds the fair market value of the share on the date of exercise of the option, that excess will be short-term or long-term capital gain, depending on whether the holding period for the share exceeds one year.
An optionee who exercises an incentive stock option by delivering shares of stock acquired previously pursuant to the exercise of an incentive stock option before the expiration of the Required Holding Period for those shares is treated as making a Disqualifying Disposition of those shares. This rule prevents “pyramiding” or the exercise of an incentive stock option (that is, exercising an incentive stock option for one share and using that share, and others so acquired, to exercise successive incentive stock options) without the imposition of current income tax.
For purposes of the alternative minimum tax, the amount by which the fair market value of a share of stock acquired on exercise of an incentive stock options exceeds the exercise price of that option generally will be an adjustment included in the optionee’s alternative minimum taxable income for the year in which the option is exercised. If, however, there is a Disqualifying Disposition of the share in the year in which the option is exercised, there will be no adjustment with respect to that share. If there is a Disqualifying Disposition in a later year, no income with respect to the Disqualifying Disposition is included in the optionee’s alternative minimum taxable income for that year. In computing alternative minimum taxable income, the tax basis of a share acquired on exercise of an incentive stock option is increased by the amount of the adjustment taken into account with respect to that share for alternative minimum tax purposes in the year the option is exercised.

 

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We are not allowed an income tax deduction with respect to the grant or exercise of an incentive stock option or the disposition of a share acquired on exercise of an incentive stock option after the Required Holding Period. However, if there is a Disqualifying Disposition of a share, we are allowed a deduction in an amount equal to the ordinary income includible in income by the optionee, provided that amount constitutes an ordinary and necessary business expense for the Registrant and is reasonable in amount, and either the employee includes that amount in income or the Registrant timely satisfies its reporting requirements with respect to that amount.
Restricted Stock Awards
Generally, the recipient of a restricted stock award will recognize ordinary compensation income at the time the restricted stock is received equal to the excess, if any, of the fair market value of the restricted stock received over any amount paid by the recipient in exchange for the restricted stock. If, however, the restricted stock is non-vested when it is received under the Participation Plan (for example, if the employee is required to work for a period of time in order to have the right to sell the stock), the recipient generally will not recognize income until the restricted stock becomes vested, at which time the recipient will recognize ordinary compensation income equal to the excess, if any, of the fair market value of the restricted stock on the date it becomes vested over any amount paid by the recipient in exchange for the restricted stock. A recipient may, however, file an election with the Internal Revenue Service, within 30 days of his receipt of the restricted stock award, to recognize ordinary compensation income, as of the date the recipient receives the award, equal to the excess, if any, of the fair market value of the restricted stock on the date the award is granted over any amount paid by the recipient in exchange for the restricted stock.
The recipient’s basis for the determination of gain or loss upon the subsequent disposition of shares acquired as restricted stock awards will be the amount paid for such shares plus any ordinary income recognized either when the restricted stock is received or when the restricted stock becomes vested. Upon the disposition of any restricted stock received as a restricted stock award under the Participation Plan, the difference between the sale price and the recipient’s basis in the shares will be treated as a capital gain or loss and generally will be characterized as long-term capital gain or loss if the shares have been held for more the one year from the date as of which he would be required to recognize any compensation income.
The Registrant will be entitled to a deduction for federal income tax purposes equal to the amount of ordinary income that the employee is required to recognize at the time so recognized by the employee, whether upon vesting or grant, if the employee makes the election described above.

 

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Section 409A
Section 409A of the Internal Revenue Code, enacted as part of the American Jobs Creation Act of 2004, imposes certain new requirements applicable to “nonqualified deferred compensation plans,” including new rules relating to the timing of deferral elections and elections with regard to the form and timing of benefit distributions, prohibitions against the acceleration of the timing of distributions, and the times when distributions may be made, as well as rules that generally prohibit the funding of nonqualified deferred compensation plans in offshore trusts or upon the occurrence of a change in the employer’s financial health. These new rules generally apply with respect to deferred compensation that becomes earned and vested on or after January 1, 2005. If a nonqualified deferred compensation plan subject to Section 409A fails to meet, or is not operated in accordance with, these new requirements, then all compensation deferred under the plan is or becomes immediately taxable to the extent that it is not subject to a substantial risk of forfeiture and was not previously taxable. The tax imposed as a result of these new rules would be increased by interest at a rate equal to the rate imposed upon tax underpayments plus one percentage point, and an additional tax equal to 20% of the compensation which is required to be included in income. Some of the awards to be granted under the Participation Plan may constitute deferred compensation subject to the Section 409A requirements. It is the Registrant’s intention that any award agreement that will govern awards subject to Section 409A will comply with these new rules.
Section 162 Limitations
The Omnibus Budget Reconciliation Act of 1993 added Section 162(m) to the Internal Revenue Code, which generally disallows a public company’s tax deduction for compensation to covered employees in excess of $1 million in any tax year beginning on or after January 1, 1994. Compensation that qualifies as “performance-based compensation” is excluded from the $1 million deductibility cap, and therefore remains fully deductible by the Registrant that pays it. The Registrant intends that options granted to employees whom the Administrator expects to be covered employees at the time a deduction arises in connection with such options will (and that other awards may be structured in a manner that may) qualify as such “performance-based compensation,” so that such options will not be subject to the Section 162(m) deductibility cap of $1 million and that other performance-based awards under the Participation Plan may be structured so as not to be subject to that limitation. Future changes in Section 162(m) or the regulations thereunder may adversely affect the Registrant’s ability to ensure that options and other awards under the Participation Plan will qualify as “performance-based compensation” that is fully deductible by us under Section 162(m).
Other Information
As the administration of the Participation Plan involves discretionary choices by the Administrator, awards to be granted under the Participation Plan in 2007 are not now determinable.

 

52


 

EXECUTIVE COMPENSATION
The following table shows information concerning the compensation paid by us for the last fiscal years to our Chief Executive Officer and our other most highly-compensated executive officers:
Summary Compensation Table(1)(2)
                                                                         
                                            Non-                    
                                            Equity                    
                                            Incentive     Nonqualified              
                                            Plan     Deferred     All Other        
                            Stock     Option     Compensa-     Compensa-     Compen-        
            Salary     Bonus     Awards     Awards     tion     tion Earnings     sation     Total  
Name and Principal Position   Year     ($)     ($)     ($)     ($)     ($)     ($)     ($)     ($)  
Kenneth C. Aldrich
Chairman of the Board
    2006     $ 180,000                     $ 233,750                                  
    2005       -0-                                                          
    2004       -0-                                                          
Jeff Krstich
Chief Executive Officer and Director (1)
    2006     $ 220,000                     $ 935,000                                  
    2005       -0-                                                          
    2004       -0-                                                          
Jeffrey Janus
President and Chief Executive Officer of Lifeline Cell Technology
    2006     $ 220,000                     $ 233,750                                  
    2005     $ 100,000                                                          
    2004     $ 100,000                                                          
                                                                       
William B. Adams
Director and Chief Financial Officer
    2006     $ 180,000                     $ 233,750                                  
    2005       -0-                                                          
    2004       -0-                                                          
 
(1)  
The 2006 numbers are annualized and reflect the salary that would have been received if the full amount of compensation had actually been paid.
 
(2)  
Mr. Aldrich and Mr. Adams were not paid a salary in from 2004 through the third quarter of 2006. However, they accrued a management fee in the amount of $10,000 per month through June 1, 2006 and thereafter a fee of $20,000 per month until they signed their employment agreements on December 2006. The management fee was payable to SeaCreat Capital, Inc., a corporation controlled by Mr. Adams and Mr. Aldrich. As of September 30, 2006, $474,984 was owed to SeaCreat Capital, Inc.
 
(3)  
Mr. Krstich joined ISC in 2006 and thus received no compensation in prior years.

 

53


 

Outstanding Equity Awards at Fiscal Year-End
                                                                         
    Option Awards     Stock Awards  
                                                            Equity     Equity  
                                                            Incentive     Incentive  
                                                            Plan     Plan  
                                                            Awards:     Awards:  
                                                            Number     Market or  
                    Equity                                     of     Payout  
                    Incentive                     Number     Market     Unearned     Value of  
                    Plan                     of     Value of     Shares or     Unearned  
            Awards:                     Shares     Shares or     Units     Shares,  
    Number of     Number of     Number of                     or Units     Units of     or Other     Units or  
    Securities     Securities     Securities                     of Stock     Stock     Rights     Other  
    Underlying     Underlying     Underlying                     That     That     That     Rights  
    Unexercised     Unexercised     Unexercised     Option             Have     Have     Have     That Have  
    Options     Options     Unearned     Exercise     Option     Not     Not     Not     Not  
    (#)     (#)     Options     Price     Expiration     Vested     Vested     Vested     Vested  
Name   Exercisable     Unexercisable     (#)     ($)     Date     (#)     ($)     (#)     ($)  
Kenneth Aldrich
Chairman
    100,000       150,000           $ 1.00       2016                          
Jeff Krstich
Chief Executive Officer and Director
    100,000       900,000           1.00       2016                          
Jeffrey Janus
Co-Founder and Chairman of the Board
    100,000       150,000           1.00       2016                          
William B. Adams
Co-Founder, Director and Chief Financial Officer
    100,000       150,000           1.00       2016                          
CERTAIN RELATIONSHIPS AND RELATED TRANSACTIONS, AND DIRECTOR INDEPENDENTS
Except with respect to the Exchange Agreement and the transactions described below, none of the Registrant’s directors or officers, nor any incoming director, nor any person who beneficially owns, directly or indirectly, shares carrying more than 10% of the voting rights attached to the Registrant’s outstanding shares, nor any of the Registrant’s promoters, nor any relative or spouse of any of the foregoing persons has any material interest, direct or indirect, in any transaction for the past two years or in any presently proposed transaction to which the Registrant was or is to be party. None of the Registrant’s directors or officers, nor any incoming director are indebted to the Registrant.
In connection with the Exchange Agreement, ISC entered into a Financial Advisory Agreement, dated October 18, 2006 (the “FAA”) with HFG pursuant to which ISC paid $450,000 to HFG. The FAA expires on October 18, 2007. The foregoing description of the FAA does not purport to be complete and is qualified in its entirety by reference to the FAA, which is to this Current Report on Form 8-K as Exhibit 10.5.
As of September 30, 2006, ISC had the following obligations to related parties:
         
Management fee
  $ 474,984  
SeaCrest Capital
    20,762  
SeaCrest Partners
    14,925  
YKA Partners
    34,382  
Gregory Keller
    23,601  
Janus Biologics, LLC
    30,656  
 
     
 
  $ 599,310  
 
     
The management fee is an accrued obligation which is payable to Mr. Adams and Mr. Aldrich, who are officers and directors of ICS. The management fee relates to the management of the Lifeline from inception at a rate of $10,000 per month plus accrued interest at 10% per annum on the unpaid balance. Effective June 1, 2006 the management fee was increased to $20,000 per month. When Mr. Adams and Aldrich became employees of International Stem Cell on December 1, 2006, accrual of the management fee ceased.
SeaCreast Capital and SeaCreast Partners are controlled by Mr. Adams and Mr. Aldrich and the amounts payable represent advances to Lifeline for operating expenses. YKA Partners is controlled by Mr. Aldrich and the amounts represent advances to the Company for operating expenses. Mr. Gregory Keller is an affiliate and the amounts payable to him represent advances to the Company for operating expenses. Janus Biologics, LLC is controlled by Jeffrey Janus who is the President of International Stem Cell and the amounts represent advances to the Company for operating expenses.

 

54


 

DESCRIPTION OF SECURITIES
General
The following summary describes the material terms of our capital stock and is subject to, and qualified by, applicable law and the provisions of our certificate of incorporation and bylaws. We have incorporated these organizational documents by reference as exhibits to this Current Report on Form 8-K.
Our certificate of incorporation authorizes us to issue 50,000,000 shares of capital stock, of which 40,000,000 shares are designated BTHC Common Stock and 10,000,000 shares are designated preferred stock.
BTHC Common Stock
Voting Rights
Holders of BTHC Common Stock are entitled to one vote per share. Subject to any voting rights granted to holders of any preferred stock, the affirmative vote of a majority of the shares present in person or by proxy and entitled to vote on the subject matter, other than the election of directors, will generally be required to approve matters voted on by our stockholders. Directors will be elected by plurality of the votes of the shares present in person or represented by a proxy at the meeting entitled to vote on the election of directors. Our certificate of incorporation does not provide for cumulative voting.
Dividends
Subject to the rights of holders of any outstanding preferred stock, the holders of outstanding shares of BTHC Common Stock will share ratably on a per share basis in any dividends declared from time to time by our Board of Directors.
Other Rights
Subject to the rights of holders of any outstanding preferred stock, upon our liquidation, dissolution or winding up, we will distribute any assets legally available for distribution to our stockholders, ratably among the holders of BTHC Common Stock outstanding at that time.
Preferred Stock
Our Board of Directors, without stockholder approval, may issue preferred stock in one or more series from time to time and fix or alter the designations, relative rights, priorities, preferences, qualifications, limitations and restrictions of the shares of each series, to the extent that those are not fixed in our certificate of incorporation.
The rights, preferences, limitations and restrictions of different series of preferred stock may differ with respect to dividend rates, amounts payable on liquidation, voting rights, conversion rights, redemption provisions, sinking fund provisions and other matters. Our Board of Directors may authorize the issuance of preferred stock that ranks senior to BTHC Common Stock with respect to the payment of dividends and the distribution of assets on liquidation. In addition, our Board of Directors can fix the limitations and restrictions, if any, upon the payment of dividends on BTHC Common Stock to be effective while any shares of preferred stock are outstanding.

 

55


 

Warrants
The Placement Agent in the ISC Private Placement was issued warrants (the “Placement Agent’s Warrants”) to purchase up to 2,400,000 shares of BTHC Common Stock at an exercise price of $1.00 per share and which are exercisable for a period of five years, commencing after the final closing of the ISC Private Placement. The Placement Agent’s Warrants contain provisions for cashless exercise and the shares issued upon exercise are required to be registered. The holders of the Placement Agent’s Warrants have no voting, dividend or other stockholder rights unless and until the exercise of such warrants. The number of warrant shares are subject to a “weighted average” adjustment to protect against any dilution upon the occurrence of certain corporate events in which shares are issued or agreed to be issued at a price less than the exercise price of the warrants.
In connection with the Share Exchange, the Registrant assumed warrants to purchase 1,629,623 shares of common stock held by investors in ISC. These warrants have exercise prices ranging from $.80 to $1.00 per share and expire at various times from 2009 to 2016.
ANTI-TAKEOVER EFFECTS OF CERTIFICATE OF INCORPORATION, BYLAWS
The Delaware General Corporation Law (the “DGCL”), our certificate of incorporation and our bylaws contain provisions, summarized below, that may delay, defer or inhibit a future acquisition of us that stockholders might consider in their best interest, including takeover attempts that might result in a premium over the market price for the shares held by stockholders.
Issuance of Preferred Stock
The issuance of preferred stock pursuant to the Board of Directors’ authority described above may adversely affect the rights of the holders of BTHC Common Stock. For example, preferred stock issued by us may rank prior to BTHC Common Stock as to dividend rights, liquidation preference or both, may have full or limited voting rights and may be convertible into shares of BTHC Common Stock. Accordingly, the ability of our Board of Directors to issue undesignated preferred stock may discourage bids for BTHC Common Stock or may otherwise adversely affect the market price of BTHC Common Stock. We have no present intention to issue shares of preferred stock.
Advance Notice Requirements
Our bylaws impose advance notice requirements for stockholder proposals and nominations of directors to be considered at meetings of stockholders.
Our certificate of incorporation permits our Board of Directors to amend, alter or repeal our bylaws, except to the extent otherwise provided therein, without the assent or vote of stockholders.

 

56


 

MARKET PRICE AND DIVIDENDS ON COMMON EQUITY AND RELATED STOCKHOLDER MATTERS
Trading Information
The BTHC Common Stock is quoted on the OTC Bulletin Board under the trading symbol BTCH.OB. At this time there is no active trading market in our stock and trading cannot commence until a Certificate of Compliance is filed with the United States Bankruptcy Court for the Northern District of Texas, Dallas Division.
Transfer Agent
The transfer agent and registrar for BTHC Common Stock is Securities Transfer Company, Inc., 2591 Dallas Parkway, Frisco, Texas 75034; telephone: (469) 630-0100.
Holders of Record
After giving effect to the Share Exchange, there were approximately 800 holders of record of BTHC Common Stock.
Dividends
We have not paid any dividends on BTHC Common Stock and we do not intend to pay any dividends on BTHC Common Stock in the foreseeable future.
INDEMNIFICATION OF DIRECTORS AND OFFICERS
Under Delaware law, a Delaware corporation may indemnify any person who was or is a party or is threatened to be made a party to any threatened, pending or completed action, suit or proceeding, whether civil, criminal, administrative or investigative (other than an action by or in the right of the corporation) by reason of the fact that the person is or was a director, officer, employee or agent of the corporation, or is or was serving at the request of the corporation as a director, officer, employee or agent of another corporation, partnership, joint venture, trust or other enterprise against expenses (including attorneys’ fees), judgments, fines, and amounts paid in settlement actually and reasonably incurred by the person in connection with such action, suit or proceeding if the person acted in good faith and in a manner the person reasonably believed to be in or not opposed to the best interests of the corporation, and, with respect to any criminal action or proceeding, had no reasonable cause to believe that the person’s conduct was unlawful.
In the case of a derivative action, a Delaware corporation may indemnify any such person against expenses, including attorneys’ fees, actually and reasonably incurred by such person in connection with the defense or settlement of such action or suit if the person acted in good faith and in a manner the person reasonably believed to be in or not opposed to the best interests of the corporation, except that no indemnification will be made in respect on any claim, issue or matter as to which such person will have been adjudged to be liable to the corporation unless, and only to the extent, that the Court of Chancery of the State of Delaware or any other court in which such action or suit was brought determines that such person is fairly and reasonably entitled to indemnity for such expense.

 

57


 

Delaware law permits a corporation to include in its certificate of incorporation a provision eliminating or limiting a director’s personal liability to a corporation or its stockholders for monetary damages for breaches of fiduciary duty as a director. Delaware Law provides, however, that a corporation cannot eliminate or limit a director’s liability for (i) any breach of the director’s duty of loyalty to the corporation or its stockholders; (ii) for acts or omissions not in good faith or which involve intentional misconduct or a knowing violation of law; (iii) the unlawful purchase or redemption of stock or payment of unlawful purchase or redemption of stock or payment of unlawful dividends; or (iv) for any transaction from which the director derived an improper personal benefit. Furthermore, such provision cannot eliminate or limit the liability of a director for any act or omission occurring prior to the date when such provision became effective.
Our certificate of incorporation provides that we will indemnify our directors to the fullest extent permitted by Delaware law and may indemnify our officers and any other person whom we have the power to indemnify against any liability, reasonable expense or other matter whatsoever.
Under Delaware law, a corporation may also purchase and maintain insurance on behalf of any person who is or was a director, officer, employee or agent of the corporation, or is or was serving at the request of the corporation as a director, officer, employee or agent of another corporation, partnership, joint venture, trust or other enterprise against any liability asserted against such person and incurred by such person in any such capacity, or arising out of such person’s status as such, whether or not the corporation would have the power to indemnify such person against such liability.
The Board of Directors of the Registrant has agreed to indemnify each of its officers and directors to the fullest extent permitted by Delaware law. We believe that these limitations on liability are essential to attracting and retaining qualified persons as directors and executive officers. We currently do not have insurance insuring directors and officers against liability; however, we are in the process of acquiring such insurance.
Item 3.02  
Unregistered Sales of Equity Securities.
In connection with the Share Exchange, we issued 33,111,502 shares of BTHC Common Stock to the ISC Shareholders. The issuance of these shares was exempt from registration, in part pursuant to Regulation S and Regulation D under the Securities Act and in part pursuant to Section 4(2) of the Securities Act.

 

58


 

Item 4.01  
Changes in Registrant’s Certifying Accountant.
On December 28, 2006, upon the closing of the Share Exchange, we terminated S.W. Hatfield, CPA (“SWH”), as our independent registered public accounting firm. Vasques & Company audited our financial statements for the fiscal year ended December 31, 2005. The reason for the replacement of SWH was that, following the Share Exchange, the former shareholders of International Stem Cell own a majority of the outstanding shares of BTHC Common Stock. International Stem Cell is our primary business unit, and the current independent registered public accountants of International Stem Cell is the firm of Vasques & Company. We believe that it is in our best interest to have Vasques & Company continue to work with our business, and we therefore retained Vasques & Company as our new independent registered public accounting firm effective as of December 28, 2006. Vasques & Company is located at 801 South Grand Avenue, Suite 400 Los Angeles, California 90017, California.
The appointment of Vasques & Company was recommended and approved by our Board of Directors. During our two most recent fiscal years, and the subsequent interim periods, prior to December 2006 , we did not consult Vasques & Company regarding either: (i) the application of accounting principles to a specified transaction, completed or proposed, or the type of audit opinion that might be rendered on the Registrant’s financial statements, or (ii) any matter that was either the subject of a disagreement as defined in Item 304(a)(1)(iv) of Regulation S-K or a reportable event as described in Item 304(a)(1)(v) of Regulation S-K.
SWH’s report on our financial statements for the fiscal year ended December 31, 2005, did not contain any adverse opinion or disclaimer of opinion and was not qualified as audit scope or accounting principles.
During the most recent fiscal year ended December 31, 2005, (i) there were no disagreements between us and SWH on any matter of accounting principles or practices, financial statement disclosure or auditing scope or procedure which, if not resolved to the satisfaction of SWH, would have caused SWH to make reference to the subject matter of the disagreement in connection with its reports and (ii) there were no “reportable events,” as described in Item 304(a)(1)(iv) of Regulation S-B of the Exchange Act. The decision to replace SWH was not the result of any disagreement between us and SWH on any matter of accounting principle or practice, financial statement disclosure or audit procedure. Our Board of Directors deemed it in our best interest to change independent auditors following the closing of the Share Exchange.
We furnished SWH with a copy of this Current Report on Form 8-K prior to filing this Current Report on Form 8-K with the SEC. We also requested that SWH furnish a letter addressed to the SEC stating whether it agrees with the statements made in this Current Report on Form 8-K. A copy of SWH’s letter to the SEC is filed with this Report on Form 8-K as Exhibit 16.1.
Item 5.01  
Changes in Control of Registrant.
Please see Item 2.01 (Completion of Acquisition or Disposition of Assets) of this Current Report on Form 8-K, which is incorporated herein by reference.
Item 5.02  
Departure of Directors or Principal Officers; Election of Directors; Appointment of Principal Officers.
In connection with the Share Exchange, Kenneth Aldrich was appointed to the Board of Directors and will serve as the Chairman of the Board. Jeff Krstich and William B. Adams were appointed as the Chief Executive Officer and Chief Financial Officer of the Registrant, respectively. Jeffrey Janus was appointed as the President of the Registrant and Chief Executive Officer of Lifeline.

 

59


 

Item 5.06  
Change in Shell Company Status.
As a result of the consummation of the Share Exchange as described in Item 1.01 (Entry Into a Material Definitive Agreement) and Item 2.01 (Completion of Acquisition or Disposition of Assets) above, which descriptions are in their entirety incorporated by reference in this Item 5.06, we ceased being a shell company as such term is defined in Rule 12b-2 under the Exchange Act.
Item 8.01  
Other Events
We have relocated our principal executive offices to those of International Stem Cell at 2595 Jason Court, Oceanside, California 92056. Our telephone number is (760) 940-6383, our fax number is (310) 573-9699 and our website is located at www.internationalstemcell.com.
Item 9.01  
Financial Statements and Exhibits.
(a)  
Financial statements of business acquired.
The financial statements of International Stem Cell for the period beginning July 16, 2006 (inception) through September 30, 2006, are incorporated herein by reference to Exhibit 99.1 to this Current Report on Form 8-K.
The financial statements of Lifeline Cell Technology, LLC for the periods ended December 31, 2005 and 2006, are incorporated herein by reference to Exhibit 99.2 to this Current Report on Form 8-K.
The financial statements of Lifeline Cell Technology, LLC for the nine-month periods ended September 30, 2005 and 2006, are incorporated herein by reference to Exhibit 99.3 to this Current Report on Form 8-K.
(b)  
Pro Forma Financial Information.
The pro-forma financial statements of the acquired business are incorporated herein by reference to Exhibit 99.4 to this Current Report on Form 8-K.
(c)  
Exhibits.
         
Exhibit    
Number   Description
  2.1    
Share Exchange Agreement, dated as of December 28, 2006, by and among BTHC III, Inc., a Delaware corporation (the “Company”), Halter Financial Investments, L.P., a Texas limited partnership, International Stem Cell Corporation, a California corporation (“International Stem Cell”), and the Shareholders of International Stem Cell by and through the Shareholder Representative.
  3.1    
Certificate of Incorporation of the Registrant (incorporated by reference to Exhibit 3.4 of the Company’s Form 10-SB filed on April 4, 2006).
  3.2    
Bylaws of the Registrant (incorporated by reference to Exhibit 3.5 of the Company’s Form 10-SB filed on April 4, 2006).
  4.1    
Form of Lifeline Warrant.

 

60


 

         
Exhibit    
Number   Description
  4.2    
Form of Lifeline Warrant held by ISC Bridge lenders.
  4.3    
Placement Agents Warrant
  10.1    
Employment Agreement, dated December 1, 2006, by and between International Stem Cell and Kenneth C. Aldrich.
  10.2    
Employment Agreement, dated November 1, 2006, by and between International Stem Cell and William B. Adams.
  10.3    
Employment Agreement, dated March 27, 2006, by and between International Stem Cell and Jeff Krstich.
  10.4    
Employment Agreement, dated October 31, 2006, by and between International Stem Cell and Jeffrey Janus.
  10.5    
Advisory Agreement, dated as of October 18, 2006, by and between International Stem Cell and Halter Financial Group, L.P.
  10.6    
Consulting Agreement, effective as of September 1, 2006, by and between International Stem Cell and Capital Group Communications, Inc.
  10.7    
Lifeline/ASC Final Settlement Agreement, effective as of June 30, 2006, by and between each of the American Stem Cell Corporation Parties (which include American Stem Cell Corporation Kenneth Swaisland, Ken Sorensen, Milton Datsopoulos, Michael McClain, Array Capital, Catalytix LDC, Catalytix Life Sciences Hedge, Avion Holdings, Inc., jointly and severally) and the Lifeline Parties (which include Lifeline Cell Technology, LLC (“Lifeline”), Jeffrey Janus, William B. Adams, Kenneth C. Aldrich, jointly and severally).
  10.8    
Promissory Note, dated as of June 30, 2006, by Lifeline in favor of American Stem Cell Corporation.
  10.9    
First Amendment to Exclusive License Agreement (ACT IP), dated as of August 1, 2005, by and between Advanced Cell, Inc. and Lifeline.

 

61


 

         
Exhibit    
Number   Description
  10.10    
First Amendment to Exclusive License Agreement (UMass IP), dated as of August 1, 2005, by and between Advanced Cell, Inc. and Lifeline.
  10.11    
First Amendment to Exclusive License Agreement (Infigen IP), dated as of August 1, 2005, by and between Advanced Cell, Inc. and Lifeline.
  10.12    
Exclusive License Agreement (Infigen IP), dated as of May 14, 2004, by and between Advanced Cell Technology, Inc and PacGen Cellco, LLC (predecessor company of Lifeline).
  10.13    
Exclusive License Agreement (ACT IP), dated as of May 14, 2004, by and between Advanced Cell Technology, Inc. and PacGen Cellco, LLC (predecessor company of Lifeline).
  10.14    
Exclusive License Agreement (UMass IP), dated as of May 14, 2004, by and between Advanced Cell Technology, Inc. and PacGen Cellco, LLC (predecessor company of Lifeline).
  10.15    
International Stem Cell Corporation 2006 Equity Participation Plan.
  14.1    
Code of Ethics
  16.1    
Letter from S.W. Hatfield, CPA.
  21.1    
Subsidiaries of the Company.
  99.1    
Financial Statements of International Stem Cell as of and for the period beginning June 16, 2006 (inception) and ending September 30, 2006.
  99.2    
Financial Statements of Lifeline as of and for the years ended December 31, 2005 and December 31, 2004.
  99.3    
Financial Statements of Lifeline as of and for the nine months ended September 30, 2006 and September 30, 2005 (unaudited).
  99.4    
Pro forma unaudited consolidated balance sheet of International Stem Cell as at September 30, 2006, pro forma unaudited consolidated statement of operations for the nine months ended September 30, 2006, and pro forma unaudited consolidated statement of operations for the year ended December 31, 2005.

 

62


 

SIGNATURES
Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.
         
  BTHC III, INC.
 
 
Dated: December 28, 2006  By:   /s/ Jeff Krstich  
    Name:   Jeff Krstich   
    Title:   Chief Executive Officer   

 

 


 

EXHIBIT INDEX
         
Exhibit    
Number   Description
  2.1    
Share Exchange Agreement, dated as of December 28, 2006, by and among BTHC III, Inc., a Delaware corporation (the “Company”), Halter Financial Investments, L.P., a Texas limited partnership, International Stem Cell Corporation, a California corporation (“International Stem Cell”), and the Shareholders of International Stem Cell by and through the Shareholder Representative.
  3.1    
Certificate of Incorporation of the Registrant (incorporated by reference to Exhibit 3.4 of the Company’s Form 10-SB filed on April 4, 2006).
  3.2    
Bylaws of the Registrant (incorporated by reference to Exhibit 3.5 of the Company’s Form 10-SB filed on April 4, 2006).
  4.1    
Form of Lifeline Warrant.
  4.2    
Form of Lifeline Warrant held by ISC Bridge lenders.
  4.3    
Placement Agents Warrant
  10.1    
Employment Agreement, dated December 1, 2006, by and between International Stem Cell and Kenneth C. Aldrich.
  10.2    
Employment Agreement, dated November 1, 2006, by and between International Stem Cell and William B. Adams.
  10.3    
Employment Agreement, dated March 27, 2006, by and between International Stem Cell and Jeff Krstich.
  10.4    
Employment Agreement, dated October 31, 2006, by and between International Stem Cell and Jeffrey Janus.
  10.5    
Advisory Agreement, dated as of October 18, 2006, by and between International Stem Cell and Halter Financial Group, L.P.
  10.6    
Consulting Agreement, effective as of September 1, 2006, by and between International Stem Cell and Capital Group Communications, Inc.
  10.7    
Lifeline/ASC Final Settlement Agreement, effective as of June 30, 2006, by and between each of the American Stem Cell Corporation Parties (which include American Stem Cell Corporation Kenneth Swaisland, Ken Sorensen, Milton Datsopoulos, Michael McClain, Array Capital, Catalytix LDC, Catalytix Life Sciences Hedge, Avion Holdings, Inc., jointly and severally) and the Lifeline Parties (which include Lifeline Cell Technology, LLC (“Lifeline”), Jeffrey Janus, William B. Adams, Kenneth C. Aldrich, jointly and severally).
  10.8    
Promissory Note, dated as of June 30, 2006, by Lifeline in favor of American Stem Cell Corporation.
  10.9    
First Amendment to Exclusive License Agreement (ACT IP), dated as of August 1, 2005, by and between Advanced Cell, Inc. and Lifeline.
  10.10    
First Amendment to Exclusive License Agreement (UMass IP), dated as of August 1, 2005, by and between Advanced Cell, Inc. and Lifeline.
  10.11    
First Amendment to Exclusive License Agreement (Infigen IP), dated as of August 1, 2005, by and between Advanced Cell, Inc. and Lifeline.
  10.12    
Exclusive License Agreement (Infigen IP), dated as of May 14, 2004, by and between Advanced Cell Technology, Inc and PacGen Cellco, LLC (predecessor company of Lifeline).
  10.13    
Exclusive License Agreement (ACT IP), dated as of May 14, 2004, by and between Advanced Cell Technology, Inc. and PacGen Cellco, LLC (predecessor company of Lifeline).
  10.14    
Exclusive License Agreement (UMass IP), dated as of May 14, 2004, by and between Advanced Cell Technology, Inc. and PacGen Cellco, LLC (predecessor company of Lifeline).
  10.15    
International Stem Cell Corporation 2006 Equity Participation Plan.
  14.1    
Code of Ethics
  16.1    
Letter from S.W. Hatfield, CPA.
  21.1    
Subsidiaries of the Company.
  99.1    
Financial Statements of International Stem Cell as of and for the period beginning June 16, 2006 (inception) and ending September 30, 2006.
  99.2    
Financial Statements of Lifeline as of and for the years ended December 31, 2005 and December 31, 2004.
  99.3    
Financial Statements of Lifeline as of and for the nine months ended September 30, 2006 and September 30, 2005 (unaudited).
  99.4    
Pro forma unaudited consolidated balance sheet of International Stem Cell as at September 30, 2006, pro forma unaudited consolidated statement of operations for the nine months ended September 30, 2006, and pro forma unaudited consolidated statement of operations for the year ended December 31, 2005.

 

 

 

Exhibit 2.1

SHARE EXCHANGE AGREEMENT
This SHARE EXCHANGE AGREEMENT (this “ Agreement ”), dated as of December 28, 2006, is by and among BTHC III, Inc., a Delaware corporation (“ Parent ”), Halter Financial Investments, L.P., a Texas limited partnership (the “ Stockholder” ), International Stem Cell Corporation, a California corporation (the “ Company ”), and the Shareholders of the Company by and through the Shareholder Representative (the “ Shareholders ”).
RECITALS
WHEREAS, the Company has 33,111,502 shares of common stock (the “ Company Stock ”) outstanding, all of which are held by the Shareholders.
WHEREAS, each of the Shareholders is the record and beneficial owner of the number of shares of Company Stock set forth opposite such Shareholder’s name on Exhibit A attached hereto, and each of the Shareholders has agreed to transfer all of his, her or its shares of Company Stock in exchange for the number of newly issued shares of Common Stock, par value $0.001 per share, of Parent (the “ Parent Stock ”) listed opposite such Shareholder’s name on Exhibit A attached hereto, which in the aggregate amount to a total of 33,111,502 shares of Parent Stock (the “ Shares ”).
WHEREAS, the Stockholder is a majority shareholder of the Company and Timothy Halter, a member of Halter Financial Investments, GP, LLC, the general partner of the Stockholder is the sole officer and director of Parent.
WHEREAS, the exchange of Company Stock for Parent Stock is intended to constitute a reorganization within the meaning of Sections 351 and 368(a)(1)(B) of the Internal Revenue Code of 1986, as amended (the “ Code ”), or such other tax free reorganization exemptions that may be available under the Code.
WHEREAS, the Boards of Directors of Parent and the Company have approved the transactions contemplated hereby.
AGREEMENT
NOW, THEREFORE, in consideration of the mutual promises and covenants contained herein and for other good and valuable consideration, the receipt and sufficiency of which is hereby acknowledged, the parties hereto, intending to be legally bound, hereby agree as follows:

 

 


 

ARTICLE I
THE EXCHANGE
SECTION 1.01. Exchange .
(a) Shares . Subject to the terms and conditions of this Agreement, on the Closing Date (as defined in Section 1.02), each of the Shareholders shall sell, transfer, convey, assign and deliver to Parent its Company Stock free and clear of all Liens (as defined below) in exchange for the number of authorized but unissued shares of Parent Stock listed on Exhibit A attached hereto, opposite such Shareholder’s name.
(b) Derivative Securities . Subject to the terms and conditions of this Agreement, on the Closing Date, each outstanding derivate security set forth in Section 3.02 of the Company Disclosure Schedule shall upon the same terms and conditions set forth therein, without any further action, represent the right to acquire Parent Common Stock.
SECTION 1.02. Closing . The closing (the “ Closing ”) of the transactions contemplated hereby (the “ Transactions ”) shall take place at the offices of Katten Muchin Rosenman LLP on the date hereof (the “ Closing Date ”) at 10:00 a.m., it being understood and agreed that the closing shall be deemed to occur simultaneously with the execution of this Agreement.
ARTICLE II
REPRESENTATIONS AND WARRANTIES OF
THE SHAREHOLDER REPRESENTATIVE
The Shareholder Representative, on behalf of himself and, based solely upon the representation and warranties of each Shareholder in the subscription agreement whereby each became a shareholder of the Company, each other Shareholder represents and warrants to Parent, as follows:
SECTION 2.01. Good Title . Each Shareholder is the record and beneficial owner, and has good title to its Company Stock, with the right and authority to sell and deliver such Company Stock. Upon delivery of any certificate or certificates duly assigned, representing the same as herein contemplated and/or upon registering of Parent as the new owner of such Company Stock in the share register of the Company, Parent will receive good title to such Company Stock, free and clear of all liens, security interests, pledges, equities and claims of any kind, voting trusts, Shareholder agreements and other encumbrances (collectively, “ Liens ”).
SECTION 2.02. Power and Authority . Each Shareholder that is an entity has the legal power and authority to execute and deliver this Agreement and to perform its obligations hereunder. All acts required to be taken by the Shareholders to enter into this Agreement and to carry out the Transactions have been properly taken. This Agreement constitutes a legal, valid and binding obligation of the Shareholder, enforceable against such Shareholder in accordance with the terms hereof.

 

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SECTION 2.03. Purchase Entirely for Own Account. The Parent Stock proposed to be acquired by each Shareholder hereunder will be acquired for investment for its own account, and not with a view to the resale or distribution of any part thereof, and the Shareholder has no present intention of selling or otherwise distributing the Parent Stock, except in compliance with applicable securities laws.
SECTION 2.04. Available Information . Each Shareholder has such knowledge and experience in financial and business matters that it is capable of evaluating the merits and risks of investment in Parent.
SECTION 2.05. Non-Registration . Each Shareholder understands that the Parent Stock has not been registered under the Securities Act of 1933, as amended (the “ Securities Act ”), and, if issued in accordance with the provisions of this Agreement, will be issued by reason of a specific exemption from the registration provisions of the Securities Act which depends upon, among other things, the bona fide nature of the investment intent and the accuracy of the Shareholder’s representations as expressed herein.
SECTION 2.06. Restricted Securities . Each Shareholder understands that the Parent Stock is characterized as “restricted securities” under the Securities Act inasmuch as this Agreement contemplates that, if acquired by such Shareholder pursuant hereto, the Parent Stock would be acquired in a transaction not involving a public offering. Each Shareholder further acknowledges that if the Parent Stock is issued to such Shareholder in accordance with the provisions of this Agreement, such Parent Stock may not be resold without registration under the Securities Act or the existence of an exemption therefrom. Each Shareholder represents that it is familiar with Rule 144 promulgated under the Securities Act, as presently in effect, and understands the resale limitations imposed thereby and by the Securities Act.
SECTION 2.07. Legends . It is understood that the Parent Stock will bear the following legend:
THE SECURITIES REPRESENTED BY THIS CERTIFICATE HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933 (THE “SECURITIES ACT”), OR UNDER APPLICABLE STATE SECURITIES LAWS. SUCH SECURITIES HAVE BEEN ACQUIRED FOR INVESTMENT PURPOSES AND MAY NOT BE OFFERED FOR SALE, SOLD, DELIVERED AFTER SALE, TRANSFERRED, PLEDGED OR HYPOTHECATED IN THE ABSENCE OF AND EFFECTIVE REGISTRATION STATEMENT FILED BY THE ISSUER WITH THE U.S. SECURITIES AND EXCHANGE COMMISSION COVERING SUCH SECURITIES UNDER THE SECURITIES ACT OR OPINION OF COUNSEL SATISFACTORY TO THE ISSUE THAT SUCH REGISTRATION IS NOT REQUIRED.
It is further understood that the Parent Stock will bear any legend required by the “blue sky” laws of any state to the extent such laws are applicable to the securities represented by the certificate so legended.

 

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ARTICLE III
REPRESENTATIONS AND WARRANTIES OF THE COMPANY
Except as set forth in the written disclosure schedule prepared and delivered to Parent simultaneously with the execution hereof (the “ Company Disclosure Schedule ”), the Company represents and warrants to Parent as follows:
SECTION 3.01. Organization, Standing and Power . Each of the Company and its subsidiaries (“ Company Subsidiaries ”) is duly organized, validly existing and in good standing under the laws of the jurisdiction in which it is organized and has the corporate power and authority and possesses all governmental franchises, licenses, permits, authorizations and approvals necessary to enable it to own, lease or otherwise hold its properties and assets and to conduct its businesses as presently conducted, other than such franchises, licenses, permits, authorizations and approvals the lack of which, individually or in the aggregate, has not had and would not reasonably be expected to have a material adverse effect on the Company, a material adverse effect on the ability of the Company to perform its obligations under this Agreement or on the ability of the Company to consummate the Transactions (a “ Company Material Adverse Effect ”). The Company and each Company Subsidiary is duly qualified to do business in each jurisdiction where the nature of its business or its ownership or leasing of its properties make such qualification necessary except where the failure to so qualify would not reasonably be expected to have a Company Material Adverse Effect. The Company has delivered to Parent true and complete copies of the Certificate of Incorporation and Bylaws of the Company (the “ Company Charter Documents ”), and the comparable charter documents of each Company Subsidiary, in each case as amended through the date of this Agreement.
SECTION 3.02. Capital Structure . The authorized capital stock of the Company consists of 50,000,000 shares of common stock which, 33,111,502 shares are issued and outstanding and 15,000,000 shares are reserved for issuance under the Company’s 2006 Stock Option Plan. Except as set forth above, no shares of capital stock or other voting securities of the Company are issued, reserved for issuance or outstanding. Except as specified in the Company Disclosure Schedule, the Company is the sole record and beneficial owner of all of the issued and outstanding capital stock of each Company Subsidiary. All outstanding shares of the capital stock of the Company and each Company Subsidiary are duly authorized, validly issued, fully paid and nonassessable and not subject to or issued in violation of any purchase option, call option, right of first refusal, preemptive right, subscription right or any similar right. Except as set forth in this Section 3.02 and in Section 3.02 of the Company Disclosure Schedule, there are not any bonds, debentures, notes or other indebtedness of Company or any Company Subsidiary having the right to vote (or convertible into, or exchangeable for, securities having the right to vote) on any matters on which holders of Company Stock or the common stock of any Company Subsidiary may vote (“ Voting Company Debt ”). Except as set forth above or in the Company Disclosure Schedule, as of the date of this Agreement, there are not any options, warrants, rights, convertible or exchangeable securities, “phantom” stock rights, stock appreciation rights, stock-based performance units, commitments, Contracts, arrangements or undertakings of any kind to which the Company or any Company Subsidiary is a party or by which any of them is bound (i) obligating the Company or any Company Subsidiary to issue, deliver or sell, or cause to be issued, delivered or sold, additional shares of capital stock or other equity interests in, or any

 

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security convertible or exercisable for or exchangeable into any capital stock of or other equity interest in, the Company or any Company Subsidiary or any Voting Company Debt, (ii) obligating the Company or any Company Subsidiary to issue, grant, extend or enter into any such option, warrant, call, right, security, commitment, Contract, arrangement or undertaking or (iii) that give any person the right to receive any economic benefit or right similar to or derived from the economic benefits and rights occurring to holders of the capital stock of the Company or of any Company Subsidiary. Except as set forth in the Company Disclosure Schedule, as of the date of this Agreement, there are not any outstanding contractual obligations of the Company to repurchase, redeem or otherwise acquire any shares of capital stock of Parent.
SECTION 3.03. Authority; Execution and Delivery; Enforceability . The Company has all requisite corporate power and authority to execute and deliver this Agreement and to consummate the Transactions. The execution and delivery by the Company of this Agreement and the consummation by the Company of the Transactions have been duly authorized and approved by the Board of Directors of the Company and no other corporate proceedings on the part of the Company are necessary to authorize this Agreement and the Transactions. When executed and delivered, this Agreement will be enforceable against the Company in accordance with its terms.
SECTION 3.04. No Conflicts; Consents .
(a) Except as set forth in the Company Disclosure Schedule, the execution and delivery by the Company of this Agreement does not, and the consummation of the Transactions and compliance with the terms hereof and thereof will not, conflict with, or result in any violation of or default (with or without notice or lapse of time, or both) under, or give rise to a right of termination, cancellation or acceleration of any obligation or to loss of a material benefit under, or result in the creation of any Lien upon any of the properties or assets of the Company or any Company Subsidiary under, any provision of (i) the Company Charter Documents or the comparable charter or organizational documents of any Company Subsidiary, (ii) any material contract, lease, license, indenture, note, bond, agreement, permit, concession, franchise or other instrument (a “ Contract ”) to which the Company or any Company Subsidiary is a party or by which any of their respective properties or assets is bound or (iii) subject to the filings and other matters referred to in Section 3.04(b), any material judgment, order or decree (“ Judgment ”) or material Law (as defined below in this Section 3.04(a)) applicable to the Company or any Company Subsidiary or their respective properties or assets, other than, in the case of clauses (ii) and (iii) above, any such items that, individually or in the aggregate, have not had and would not reasonably be expected to have a Company Material Adverse Effect. For purposes of this Agreement, “ Law ” means any domestic or foreign federal, state or local statute, law (whether statutory or common law), ordinance, rule, administrative interpretation, regulation, order, writ, injunction, directive, judgment, decree, policy, guideline or other requirement.
(b) Except as set forth in the Company Disclosure Schedule and except for required filings with the Securities and Exchange Commission (the “ SEC ”) and applicable “blue sky” or state securities commissions, no material consent, approval, license, permit, order or authorization (“ Consent ”) of, or registration, declaration or

 

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filing with, or permit from, any Governmental Entity (as defined in this Section 3.04(b)) is required to be obtained or made by or with respect to the Company or any Company Subsidiary in connection with the execution, delivery and performance of this Agreement or the consummation of the Transactions. For purposes of this Agreement, “ Governmental Entity ” means any United States or foreign government, any state or other political subdivision thereof, any entity exercising executive, legislative, judicial, regulatory or administrative functions of or pertaining to government, or any other authority, agency, department, board, commission or instrumentality of the United States, any state of the United States or any political subdivision thereof or any foreign jurisdiction, and any court, tribunal or arbitrator(s) of competent jurisdiction, and any United States or foreign governmental or non-governmental self-regulatory organization, agency or authority.
SECTION 3.05. Taxes .
(a) Each of the Company and each Company Subsidiary has timely filed, or has caused to be timely filed on its behalf, all Tax Returns (as defined in this Section 3.05) required to be filed by it, and all such Tax Returns are true, complete and accurate, except to the extent any failure to file or any inaccuracies in any filed Tax Returns, individually or in the aggregate, have not had and would not reasonably be expected to have a Company Material Adverse Effect. All Taxes (as defined in this Section 3.05) shown to be due on such Tax Returns, or otherwise owed, have been timely paid, except to the extent that any failure to pay, individually or in the aggregate, has not had and would not reasonably be expected to have a Company Material Adverse Effect. There are no unpaid taxes in any material amount claimed to be due by the taxing authority of any jurisdiction, and the officers of the Company know of no basis for any such claim.
(b) The Company Financial Statements (as defined in Section 3.14) reflect an adequate reserve for all Taxes payable by the Company and the Company Subsidiaries (in addition to any reserve for deferred Taxes to reflect timing differences between book and Tax items) for all Taxable periods and portions thereof through the date of such financial statements. No deficiency with respect to any Taxes has been proposed, asserted or assessed against the Company or any Company Subsidiary, and no requests for waivers of the time to assess any such Taxes are pending, except to the extent any such deficiency or request for waiver, individually or in the aggregate, has not had and would not reasonably be expected to have a Company Material Adverse Effect.
(c) For purposes of this Agreement:
Taxes ” includes all forms of taxation, whenever created or imposed, and whether of the United States or elsewhere, and whether imposed by a local, municipal, governmental, state, foreign, federal or other Governmental Entity, or in connection with any agreement with respect to Taxes, including all interest, penalties and additions imposed with respect to such amounts.

 

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Tax Return ” means all federal, state, local, provincial and foreign Tax returns, declarations, statements, reports, schedules, forms and information returns and any amended Tax return relating to Taxes.
SECTION 3.06. Benefit Plans .
(a) Except as set forth in the Company Disclosure Schedule, the Company does not have or maintain any collective bargaining agreement or any bonus, pension, profit sharing, deferred compensation, incentive compensation, stock ownership, stock purchase, stock option, phantom stock, retirement, vacation, severance, disability, death benefit, hospitalization, medical or other plan, arrangement or understanding (whether or not legally binding) providing benefits to any current or former employee, officer or director of the Company or any Company Subsidiary (collectively, “ Company Benefit Plans ”). Except as set forth in the Company Disclosure Schedule, as of the date of this Agreement there are not any severance or termination agreements or arrangements between the Company or any Company Subsidiary and any current or former employee, officer or director of the Company or any Company Subsidiary, nor does the Company or any Company Subsidiary have any general severance plan or policy.
(b) Since September 30, 2006, there has not been any adoption or amendment in any material respect by the Company or any Company Subsidiary of any Company Benefit Plan.
SECTION 3.07. Litigation . There is no action, suit, inquiry, notice of violation, proceeding (including any partial proceeding such as a deposition) or investigation pending or threatened in writing against or affecting the Company, any Company Subsidiary or any of their respective properties before or by any court, arbitrator, governmental or administrative agency, regulatory authority (federal, state, county, local or foreign), stock market, stock exchange or trading facility (“ Action ”) which (i) adversely affects or challenges the legality, validity or enforceability of any of this Agreement or the Shares or (ii) could, if there were an unfavorable decision, individually or in the aggregate, have or reasonably be expected to result in a Company Material Adverse Effect. Neither the Company nor any Company Subsidiary, nor any director or officer thereof (in his or her capacity as such), is or has been the subject of any Action involving a claim or violation of or liability under federal or state securities laws or a claim of breach of fiduciary duty.
SECTION 3.08. Compliance with Applicable Laws . The Company and the Company Subsidiaries are in compliance with all applicable Laws, including those relating to occupational health and safety and the environment, except for instances of noncompliance that, individually and in the aggregate, have not had and would not reasonably be expected to have a Company Material Adverse Effect. Except as set forth in the Company Disclosure Schedule, the Company has not received any written communication during the past two years from a Governmental Entity that alleges that the Company is not in compliance in any material respect with any applicable Law. This Section 3.08 does not relate to matters with respect to Taxes, which are the subject of Section 3.05.

 

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SECTION 3.09. Brokers; Schedule of Fees and Expenses . No broker, investment banker, financial advisor or other person is entitled to any broker’s, finder’s, financial advisor’s or other similar fee or commission in connection with the Transactions based upon arrangements made by or on behalf of the Company.
SECTION 3.10. Contracts . Except as disclosed in the Company Disclosure Schedule, there are no Contracts (as defined in this Section 3.10) that are material to the business, properties, assets, condition (financial or otherwise), results of operations or prospects of the Company and its subsidiaries taken as a whole. Neither the Company nor any Company Subsidiary is in violation of or in default under (nor does there exist any condition which upon the passage of time or the giving of notice would cause such a violation of or default under) any Contract to which it is a party or by which it or any of its properties or assets is bound, except for violations or defaults that would not, individually or in the aggregate, reasonably be expected to result in a Company Material Adverse Effect. For purposes of this Agreement, “ Contract ” means any lease, license, contract, subcontract, indenture, note, option, or other agreement, instrument or obligation, oral or written, to which the Company is a party or by which the Company or any of its properties or assets may be bound.
SECTION 3.11. Title to Properties . Except as set forth in the Company Disclosure Schedule, the Company and the Company Subsidiaries do not own any real property. Each of the Company and the Company Subsidiaries has sufficient title to, or valid leasehold interests in, all of its properties and assets used in the conduct of its businesses. All such assets and properties, other than assets and properties in which the Company or any of the Company Subsidiaries has leasehold interests, are free and clear of all Liens other than those set forth in the Company Disclosure Schedule and except for Liens that, in the aggregate, do not and will not materially interfere with the ability of the Company and the Company Subsidiaries to conduct business as currently conducted.
SECTION 3.12. Intellectual Property . The Company and the Company Subsidiaries own, or are validly licensed or otherwise have the right to use, all patents, patent rights, trademarks, trademark rights, trade names, trade name rights, service marks, service mark rights, copyrights and other proprietary intellectual property rights and computer programs (collectively, “ Intellectual Property Rights ”) which are material to the conduct of the business of the Company and the Company Subsidiaries taken as a whole. The Company Disclosure Schedule sets forth a description of all Intellectual Property Rights which are material to the conduct of the business of the Company and the Company Subsidiaries taken as a whole. There are no claims pending or, to the knowledge of the Company, threatened that the Company or any of the Company Subsidiaries is infringing or otherwise adversely affecting the rights of any person with regard to any Intellectual Property Right. To the knowledge of the Company, no person is infringing the rights of the Company or any of the Company Subsidiaries with respect to any Intellectual Property Right.
SECTION 3.13. Labor Matters . There are no collective bargaining or other labor union agreements to which the Company or any of the Company Subsidiaries is a party or by which any of them is bound. No material labor dispute exists or, to the knowledge of the Company, is imminent with respect to any of the employees of the Company.

 

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SECTION 3.14. Financial Statements . The Company has delivered to Parent its audited consolidated financial statements for the fiscal years ended December 31, 2005 and 2004 and unaudited financial statements for the nine-month period ended September 30, 2006 (collectively, the “ Company Financial Statements ”). The Company Financial Statements have been prepared in accordance with U.S. generally accepted accounting principles (“ GAAP ”) applied on a consistent basis throughout the periods indicated, except, in the case of the financial statements for the fiscal quarter ended September 30, 2006, for the omission of footnotes. The Company Financial Statements fairly present in all material respects the financial condition and operating results of the Company, as of the dates, and for the periods, indicated therein. The Company does not have any material liabilities or obligations, contingent or otherwise, other than (i) liabilities incurred in the ordinary course of business subsequent to September 30, 2006, and (ii) obligations under contracts and commitments incurred in the ordinary course of business and not required under GAAP to be reflected in the Company Financial Statements, which, in both cases, individually and in the aggregate would not be reasonably expected to result in a Company Material Adverse Effect.
SECTION 3.15. Insurance . The Company and the Company Subsidiaries are insured by insurers of recognized financial responsibility against such losses and risks and in such amounts as are prudent and customary in the businesses in which the Company and the Company Subsidiaries are engaged and in the geographic areas where they engage in such businesses. The Company has no reason to believe that it will not be able to renew its and the Company Subsidiaries’ existing insurance coverage as and when such coverage expires or to obtain similar coverage from similar insurers as may be necessary to continue its business on terms consistent with market for the Company’s and the Company Subsidiaries’ respective lines of business.
SECTION 3.16. Transactions With Affiliates and Employees . Except as set forth in the Company Disclosure Schedule and the Company Financial Statements, none of the officers or directors of the Company and, to the knowledge of the Company, none of the employees of the Company are presently a party to any transaction with the Company or any subsidiary (other than for services as employees, officers and directors), including any Contract, agreement or other arrangement providing for the furnishing of services to or by, providing for rental of real or personal property to or from, or otherwise requiring payments to or from any officer, director or such employee or, to the knowledge of the Company, any entity in which any officer, director, or any such employee has a substantial interest or is an officer, director, trustee or partner.
SECTION 3.17. Internal Accounting Controls . The Company and its subsidiaries maintain a system of internal accounting controls sufficient to provide reasonable assurance that (i) transactions are executed in accordance with management’s general or specific authorizations, (ii) transactions are recorded as necessary to permit preparation of financial statements in conformity with GAAP and to maintain asset accountability, (iii) access to assets is permitted only in accordance with management’s general or specific authorization and (iv) the recorded accountability for assets is compared with the existing assets at reasonable intervals and appropriate action is taken with respect to any differences. The Company has established disclosure controls and procedures for the Company and designed such disclosure controls and procedures to ensure that material information relating to the Company, including the Company Subsidiaries, is made known to the officers by others within those entities. The Company’s

 

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officers have evaluated the effectiveness of the Company’s controls and procedures. Since December 31, 2005, there have been no significant changes in the Company’s internal controls or, to the Company’s knowledge, in other factors that could significantly affect the Company’s internal controls.
SECTION 3.18. No Additional Agreements . The Company does not have any agreement or understanding with any Shareholders with respect to the transactions contemplated by this Agreement other than as specified in this Agreement.
SECTION 3.19. Investment Company . The Company is not, and is not an affiliate of, and immediately following the Closing will not have become, an “investment company” within the meaning of the Investment Company Act of 1940, as amended.
SECTION 3.20. Disclosure . The Company confirms that neither it nor any person acting on its behalf has provided the Stockholder or any Shareholder or their respective agents or counsel with any information that the Company believes constitutes material, non-public information except insofar as the existence and terms of the proposed transactions hereunder may constitute such information and except for information that will be disclosed by Parent under a current report on Form 8-K filed within one business days after the Closing. The Company understands and confirms that the Shareholders will rely on the foregoing representations and covenants in effecting transactions in securities of the Company. All disclosure provided to the Shareholders regarding the Company, its business and the transactions contemplated hereby, furnished by or on behalf of the Company (including the Company’s representations and warranties set forth in this Agreement) are true and correct and do not contain any untrue statement of a material fact or omit to state any material fact necessary in order to make the statements made therein, in light of the circumstances under which they were made, not misleading.
SECTION 3.21. Absence of Certain Changes or Events . Except as disclosed in the Company Financial Statements or in the Company Disclosure Schedule, from September 30, 2006 to the date of this Agreement, the Company has conducted its business only in the ordinary course, and during such period there has not been:
(a) any change in the assets, liabilities, financial condition or operating results of the Company or any Company Subsidiary, except changes in the ordinary course of business that have not caused, in the aggregate, a Company Material Adverse Effect;
(b) any damage, destruction or loss, whether or not covered by insurance, that would have a Company Material Adverse Effect;
(c) any waiver or compromise by the Company or any Company Subsidiary of a valuable right or of a material debt owed to it;
(d) any satisfaction or discharge of any lien, claim, or encumbrance or payment of any obligation by the Company or any Company Subsidiary, except in the ordinary course of business and the satisfaction or discharge of which would not have a Company Material Adverse Effect;

 

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(e) any material change to a material Contract by which the Company or any Company Subsidiary or any of its respective assets is bound or subject;
(f) any mortgage, pledge, transfer of a security interest in, or lien, created by the Company or any Company Subsidiary, with respect to any of its material properties or assets, except liens for Taxes not yet due or payable and liens that arise in the ordinary course of business and do not materially impair the Company’s or such Company Subsidiary’s ownership or use of such property or assets;
(g) any loans or guarantees made by the Company or any Company Subsidiary to or for the benefit of its employees, officers or directors, or any members of their immediate families, other than travel advances and other advances made in the ordinary course of its business;
(h) any alteration of the Company’s method of accounting or the identity of its auditors;
(i) any declaration or payment of dividend or distribution of cash or other property to Shareholders or any purchase, redemption or agreements to purchase or redeem any shares of Company Stock; or
(j) any arrangement or commitment by the Company or any Company Subsidiary to do any of the things described in this Section 3.21.
SECTION 3.22. No Undisclosed Events, Liabilities, Developments or Circumstances . No event, liability, development or circumstance has occurred or exists, or is contemplated to occur with respect to the Company, its subsidiaries or their respective business, properties, prospects, operations or financial condition, that would be required to be disclosed by the Company under applicable securities laws on a registration statement on Form S-1 filed with the SEC relating to an issuance and sale by the Company of the Company Stock and which has not been publicly announced.
ARTICLE IV
REPRESENTATIONS AND WARRANTIES OF PARENT AND
THE STOCKHOLDER
Parent and the Stockholder severally represent and warrant as follows to each of the Shareholders, the Shareholder Representative and the Company that, except as set forth in the reports, schedules, forms, statements and other documents filed by Parent with the SEC and publicly available prior to the date of the Agreement (the “ Filed Parent SEC Documents ”):
SECTION 4.01. Organization, Standing and Power . Parent is duly organized, validly existing and in good standing under the laws of the State of Delaware and has full corporate power and authority and possesses all governmental franchises, licenses, permits, authorizations and approvals necessary to enable it to own, lease or otherwise hold its properties and assets and to conduct its businesses as presently conducted, other than such franchises, licenses, permits, authorizations and approvals the lack of which, individually or in the

 

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aggregate, has not had and would not reasonably be expected to have a material adverse effect on Parent, a material adverse effect on the ability of Parent to perform its obligations under this Agreement or on the ability of Parent to consummate the Transactions (a “ Parent Material Adverse Effect ”). Parent is duly qualified to do business in each jurisdiction where the nature of its business or its ownership or leasing of its properties make such qualification necessary and where the failure to so qualify would reasonably be expected to have a Parent Material Adverse Effect. Parent has delivered to the Company true and complete copies of the Certificate of Incorporation of Parent, as amended to the date of this Agreement (as so amended, the “ Parent Charter ”), and the Bylaws of Parent, as amended to the date of this Agreement (as so amended, the “ Parent Bylaws ”).
SECTION 4.02. Subsidiaries; Equity Interests . Parent does not own, directly or indirectly, any capital stock, membership interest, partnership interest, joint venture interest or other equity interest in any person.
SECTION 4.03. Capital Structure . The authorized capital stock of Parent consists of 40,000,000 shares of Parent Stock, par value $0.001 per share, and 10,000,000 shares of preferred stock, par value $0.001 per share. As of the date hereof (i) 2,209,993 shares of Parent Stock are issued and outstanding, (ii) no shares of preferred stock are outstanding and (iii) no shares of Parent Stock or preferred stock are held by Parent in its treasury. Except as set forth above, no shares of capital stock or other voting securities of Parent were issued, reserved for issuance or outstanding. All outstanding shares of the capital stock of Parent are, and all such shares that may be issued prior to the date hereof will be when issued, duly authorized, validly issued, fully paid and nonassessable and not subject to or issued in violation of any purchase option, call option, right of first refusal, preemptive right, subscription right or any similar right under any provision of the General Corporation Law of the State of Delaware, the Parent Charter, the Parent Bylaws or any Contract to which Parent is a party or otherwise bound. There are not any bonds, debentures, notes or other indebtedness of Parent having the right to vote (or convertible into, or exchangeable for, securities having the right to vote) on any matters on which holders of Parent Stock may vote (“ Voting Parent Debt ”). Except as set forth above, as of the date of this Agreement, there are not any options, warrants, rights, convertible or exchangeable securities, “phantom” stock rights, stock appreciation rights, stock-based performance units, commitments, Contracts, arrangements or undertakings of any kind to which Parent is a party or by which it is bound (i) obligating Parent to issue, deliver or sell, or cause to be issued, delivered or sold, additional shares of capital stock or other equity interests in, or any security convertible or exercisable for or exchangeable into any capital stock of or other equity interest in, Parent or any Voting Parent Debt, (ii) obligating Parent to issue, grant, extend or enter into any such option, warrant, call, right, security, commitment, Contract, arrangement or undertaking or (iii) that give any person the right to receive any economic benefit or right similar to or derived from the economic benefits and rights occurring to holders of the capital stock of Parent. As of the date of this Agreement, there are not any outstanding contractual obligations of Parent to repurchase, redeem or otherwise acquire any shares of capital stock of Parent. Except as set forth in Section 4.25 below, Parent is not a party to any agreement granting any securityholder of Parent the right to cause Parent to register shares of the capital stock or other securities of Parent held by such securityholder under the Securities Act. The stockholder list provided to the Company is a current stockholder list generated by its stock transfer agent, and such list accurately reflects all of the issued and outstanding shares of the Parent’s Common Stock.

 

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SECTION 4.04. Authority; Execution and Delivery; Enforceability . The execution and delivery by Parent of this Agreement and the consummation by Parent of the Transactions have been duly authorized and approved by the Board of Directors of Parent and no other corporate proceedings on the part of Parent are necessary to authorize this Agreement and the Transactions. This Agreement constitutes a legal, valid and binding obligation of Parent, enforceable against Parent in accordance with the terms hereof.
SECTION 4.05. No Conflicts; Consents .
(a) The execution and delivery by Parent of this Agreement, does not, and the consummation of Transactions and compliance with the terms hereof and thereof will not, conflict with, or result in any violation of or default (with or without notice or lapse of time, or both) under, or give rise to a right of termination, cancellation or acceleration of any obligation or to loss of a material benefit under, or to increased, additional, accelerated or guaranteed rights or entitlements of any person under, or result in the creation of any Lien upon any of the properties or assets of Parent under, any provision of (i) the Parent Charter or the Parent Bylaws, (ii) any material Contract to which Parent is a party or by which any of its properties or assets is bound or (iii) subject to the filings and other matters referred to in Section 4.05(b), any material Judgment or material Law applicable to Parent or its properties or assets, other than, in the case of clauses (ii) and (iii) above, any such items that, individually or in the aggregate, have not had and would not reasonably be expected to have a Parent Material Adverse Effect.
(b) Except for the filing of the Certificate of Compliance with the United States. Bankruptcy Court for the Northern District of Texas, Dallas Division, no Consent of, or registration, declaration or filing with, or permit from, any Governmental Entity is required to be obtained or made by or with respect to Parent in connection with the execution, delivery and performance of this Agreement or the consummation of the Transactions, other than the (A) filing with the SEC of a Form 8-K and (B) filing with the SEC of reports under Sections 13 and 16 of the Exchange Act of 1934, as amended (the “ Exchange Act ”), and (C) filings under state “blue sky” laws, as may be required in connection with this Agreement and the Transactions.
SECTION 4.06. SEC Documents; Undisclosed Liabilities .
(a) Parent has filed all reports, schedules, forms, statements and other documents required to be filed by Parent with the SEC since April 4, 2006, pursuant to Sections 13(a), 14 (a) and 15(d) of the Exchange Act (the “ Parent SEC Documents ”).
(b) As of its respective filing date, each Parent SEC Document complied in all material respects with the requirements of the Exchange Act and the rules and regulations of the SEC promulgated thereunder applicable to such Parent SEC Document, and did not contain any untrue statement of a material fact or omit to state a

 

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material fact required to be stated therein or necessary in order to make the statements therein, in light of the circumstances under which they were made, not misleading. Except to the extent that information contained in any Parent SEC Document has been revised or superseded by a later filed Parent SEC Document, none of the Parent SEC Documents contains any untrue statement of a material fact or omits to state any material fact required to be stated therein or necessary in order to make the statements therein, in light of the circumstances under which they were made, not misleading. The consolidated financial statements of Parent included in the Parent SEC Documents comply as to form in all material respects with applicable accounting requirements and the published rules and regulations of the SEC with respect thereto, have been prepared in accordance with GAAP (except, in the case of unaudited statements, as permitted by the rules and regulations of the SEC) applied on a consistent basis during the periods involved (except as may be indicated in the notes thereto) and fairly present the consolidated financial position of Parent and its consolidated subsidiaries as of the dates thereof and the consolidated results of their operations and cash flows for the periods shown (subject, in the case of unaudited statements, to normal year-end audit adjustments).
(c) Except as set forth in the Filed Parent SEC Documents, Parent has no liabilities or obligations of any nature (whether accrued, absolute, contingent or otherwise) required by GAAP to be set forth on a balance sheet of Parent or in the notes thereto. To the best knowledge of the Parent, Parent is not aware of any financial and contractual obligations and liabilities (including any obligations to issue capital stock or other securities of Parent) due after the date hereof. As of the date hereof, Parent has total liabilities of less than $5,000, all of which liabilities shall be paid off at or prior to the Closing and shall in no event remain liabilities of Parent, the Company or the Shareholders following the Closing.
SECTION 4.07. Absence of Certain Changes or Events . Except as disclosed in the Filed Parent SEC Documents, from the date of the most recent audited financial statements included in the Filed Parent SEC Documents to the date of this Agreement, Parent has conducted its business only in the ordinary course, and during such period there has not been:
(a) any change in the assets, liabilities, financial condition or operating results of Parent from that reflected in the Parent SEC Documents, except changes in the ordinary course of business that have not caused, in the aggregate, a Parent Material Adverse Effect;
(b) any damage, destruction or loss, whether or not covered by insurance, that would have a Parent Material Adverse Effect;
(c) any waiver or compromise by Parent of a valuable right or of a material debt owed to it;
(d) any satisfaction or discharge of any lien, claim, or encumbrance or payment of any obligation by Parent, except in the ordinary course of business and the satisfaction or discharge of which would not have a Parent Material Adverse Effect;

 

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(e) any material change to a material Contract by which Parent or any of its assets is bound or subject;
(f) any material change in any compensation arrangement or agreement with any employee, officer, director or stockholder;
(g) any resignation or termination of employment of any officer of Parent;
(h) any mortgage, pledge, transfer of a security interest in, or lien, created by Parent, with respect to any of its material properties or assets, except liens for Taxes not yet due or payable and liens that arise in the ordinary course of business and do not materially impair Parent’s ownership or use of such property or assets;
(i) any loans or guarantees made by Parent to or for the benefit of its employees, officers or directors, or any members of their immediate families, other than travel advances and other advances made in the ordinary course of its business;
(j) any declaration, setting aside or payment or other distribution in respect of any of Parent’s capital stock, or any direct or indirect redemption, purchase, or other acquisition of any of such stock by Parent;
(k) any alteration of Parent’s method of accounting or the identity of its auditors;
(l) any issuance of equity securities to any officer, director or affiliate, except pursuant to existing Parent stock option plans; or
(m) any arrangement or commitment by Parent to do any of the things described in this Section 4.07.
SECTION 4.08. Taxes .
(a) Parent has timely filed, or has caused to be timely filed on its behalf, all Tax Returns required to be filed by it, and all such Tax Returns are true, complete and accurate, except to the extent any failure to file or any inaccuracies in any filed Tax Returns, individually or in the aggregate, have not had and would not reasonably be expected to have a Parent Material Adverse Effect. All Taxes shown to be due on such Tax Returns, or otherwise owed, has been timely paid, except to the extent that any failure to pay, individually or in the aggregate, has not had and would not reasonably be expected to have a Parent Material Adverse Effect.
(b) The most recent financial statements contained in the Filed Parent SEC Documents reflect an adequate reserve for all Taxes payable by Parent (in addition to any reserve for deferred Taxes to reflect timing differences between book and Tax items) for all Taxable periods and portions thereof through the date of such financial statements. No deficiency with respect to any Taxes has been proposed, asserted or assessed against Parent, and no requests for waivers of the time to assess any such Taxes are pending, except to the extent any such deficiency or request for waiver, individually or in the aggregate, has not had and would not reasonably be expected to have a Parent Material Adverse Effect.

 

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(c) There are no Liens for Taxes (other than for current Taxes not yet due and payable) on the assets of Parent. Parent is not bound by any agreement with respect to Taxes.
SECTION 4.09. Absence of Changes in Benefit Plans . From the date of the most recent audited financial statements included in the Filed Parent SEC Documents to the date of this Agreement, there has not been any adoption or amendment in any material respect by Parent of any collective bargaining agreement or any bonus, pension, profit sharing, deferred compensation, incentive compensation, stock ownership, stock purchase, stock option, phantom stock, retirement, vacation, severance, disability, death benefit, hospitalization, medical or other plan, arrangement or understanding (whether or not legally binding) providing benefits to any current or former employee, officer or director of Parent (collectively, “ Parent Benefit Plans ”). As of the date of this Agreement there are not any employment, consulting, indemnification, severance or termination agreements or arrangements between Parent and any current or former employee, officer or director of Parent, nor does Parent have any general severance plan or policy.
SECTION 4.10. ERISA Compliance; Excess Parachute Payments . Parent does not, and since its inception never has, maintained, or contributed to any “employee pension benefit plans” (as defined in Section 3(2) of the Employee Retirement Income Security Act of 1974, as amended (“ ERISA ”), “employee welfare benefit plans” (as defined in Section 3(1) of ERISA) or any other Parent Benefit Plan for the benefit of any current or former employees, consultants, officers or directors of Parent.
SECTION 4.11. Litigation . Except as disclosed in the Filed Parent SEC Documents , there is no Action which (i) adversely affects or challenges the legality, validity or enforceability of any of this Agreement or the Shares or (ii) could, if there were an unfavorable decision, individually or in the aggregate, have or reasonably be expected to result in a Parent Material Adverse Effect. Neither Parent nor any subsidiary, nor any director or officer thereof (in his or her capacity as such), is or has been the subject of any Action involving a claim or violation of or liability under federal or state securities laws or a claim of breach of fiduciary duty.
SECTION 4.12. Compliance with Applicable Laws . Except as disclosed in the Filed Parent SEC Documents, Parent is in compliance with all applicable Laws, including those relating to occupational health and safety and the environment, except for instances of noncompliance that, individually and in the aggregate, have not had and would not reasonably be expected to have a Parent Material Adverse Effect. Except as set forth in the Filed Parent SEC Documents, Parent has not received any written communication during the past two years from a Governmental Entity that alleges that Parent is not in compliance in any material respect with any applicable Law. Parent is in compliance with all effective requirements of the Sarbanes-Oxley Act of 2002, as amended, and the rules and regulations thereunder, that are applicable to it, except where such noncompliance could not have or reasonably be expected to result in a Parent Material Adverse Effect. This Section 4.12 does not relate to matters with respect to Taxes, which are the subject of Section 4.08.

 

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SECTION 4.13. Contracts . Except as disclosed in the Filed Parent SEC Documents, there are no Contracts that are material to the business, properties, assets, condition (financial or otherwise), results of operations or prospects of Parent taken as a whole. Parent is not in violation of or in default under (nor does there exist any condition which upon the passage of time or the giving of notice would cause such a violation of or default under) any Contract to which it is a party or by which it or any of its properties or assets is bound, except for violations or defaults that would not, individually or in the aggregate, reasonably be expected to result in a Parent Material Adverse Effect.
SECTION 4.14. Title to Properties . Parent does not own or lease any real property.
SECTION 4.15. Intellectual Property . Parent does not own, or has a valid license or right to use any Intellectual Property Rights. There are no claims pending or, to the knowledge of Parent, threatened that Parent is infringing or otherwise adversely affecting the rights of any person with regard to any Intellectual Property Right. To the knowledge of Parent, no person is infringing the rights of Parent with respect to any Intellectual Property Right.
SECTION 4.16. Labor Matters . There are no collective bargaining or other labor union agreements to which Parent is a party or by which it is bound. No material labor dispute exists or, to the knowledge of Parent, is imminent with respect to any of the employees of Parent.
SECTION 4.17. Market Makers . Parent has one market maker for its common shares and such market maker has obtained all permits and made all filings necessary in order for such market maker to continue as market makers of Parent.
SECTION 4.18. Transactions With Affiliates and Employees . Except as set forth in the Filed Parent SEC Documents and for the Financial Advisory Agreement by and between Halter Financial Group, L.P. and the Company, dated October 18, 2006, none of the officers or directors of Parent and, to the knowledge of Parent, none of the employees of Parent is presently a party to any transaction with Parent or any subsidiary (other than for services as employees, officers and directors), including any contract, agreement or other arrangement providing for the furnishing of services to or by, providing for rental of real or personal property to or from, or otherwise requiring payments to or from any officer, director or such employee or, to the knowledge of Parent, any entity in which any officer, director, or any such employee has a substantial interest or is an officer, director, trustee or partner.
SECTION 4.19. Internal Accounting Controls . Parent maintains a system of internal accounting controls sufficient to provide reasonable assurance that (i) transactions are executed in accordance with management’s general or specific authorizations, (ii) transactions are recorded as necessary to permit preparation of financial statements in conformity with generally accepted accounting principles and to maintain asset accountability, (iii) access to assets is permitted only in accordance with management’s general or specific authorization and (iv) the recorded accountability for assets is compared with the existing assets at reasonable intervals and appropriate action is taken with respect to any differences. Parent has established

 

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disclosure controls and procedures for Parent and designed such disclosure controls and procedures to ensure that material information relating to Parent is made known to the officers by others within those entities. Parent’s officers have evaluated the effectiveness of Parent’s controls and procedures. Since December 31, 2005, there have been no significant changes in Parent’s internal controls or, to Parent’s knowledge, in other factors that could significantly affect Parent’s internal controls.
SECTION 4.20. No Liabilities . Parent has no unsatisfied judgments liens or tax liens on its assets. Further, Parent has no liability related to the Assignment and Assumption Agreement, dated November 7, 2006, by and between Parent and Bronze Marketing, Inc., a Nevada corporation (the “Assignee”), Sutor Steel Technology Co., Ltd., a British Virgin Islands corporation (“Sutor”), and the stockholders of Sutor (the “Sutor Stockholders”) pursuant to which Parent has agreed to assign to Assignee all the rights, obligations and duties of Parent under that certain Share Exchange Agreement (“Share Exchange Agreement”), dated September 7, 2006, by and among Parent, Sutor and the Sutor Stockholders.
SECTION 4.21. Application of Takeover Protections . Parent has taken all necessary action, if any, in order to render inapplicable any control share acquisition, business combination, poison pill (including any distribution under a rights agreement) or other similar anti-takeover provision under the Parent Charter, the Parent Bylaws or the laws of its state of incorporation that is or could become applicable to the Shareholders as a result of the Shareholders and Parent fulfilling their obligations or exercising their rights under this Agreement, including, without limitation, the issuance of the Shares and the Shareholders’ ownership of the Shares.
SECTION 4.22. No Additional Agreements . Parent does not have any agreement or understanding with the Shareholders with respect to the transactions contemplated by this Agreement other than as specified in this Agreement.
SECTION 4.23. Investment Company . Parent is not, and is not an affiliate of, and immediately following the Closing will not have become, an “investment company” within the meaning of the Investment Company Act of 1940, as amended.
SECTION 4.24. Disclosure . Parent confirms that neither it nor any person acting on its behalf has provided any of its stockholders, any of the Shareholders or their respective agents or counsel with any information that Parent believes constitutes material, non-public information except insofar as the existence and terms of the proposed transactions hereunder may constitute such information and except for information that will be disclosed by Parent under a current report on Form 8-K filed within one business days after the Closing. Parent understands and confirms that the Shareholders will rely on the foregoing representations and covenants in effecting transactions in securities of Parent. All disclosure provided to the Shareholders regarding Parent, its business and the transactions contemplated hereby, furnished by or on behalf of Parent (including Parent’s representations and warranties set forth in this Agreement) are true and correct and do not contain any untrue statement of a material fact or omit to state any material fact necessary in order to make the statements made therein, in light of the circumstances under which they were made, not misleading.

 

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SECTION 4.25. Certain Registration Matters . Except as specified in the Filed Parent SEC Documents and except for registration rights granted to affiliates of Timothy Halter, Parent has not granted or agreed to grant to any person any rights (including “piggy-back” registration rights) to have any securities of Parent registered with the SEC or any other governmental authority that have not been satisfied.
SECTION 4.26. Listing and Maintenance Requirements . Parent is, and has no reason to believe that it will not in the foreseeable future continue to be, in compliance with the listing and maintenance requirements for continued listing of the Parent Stock on the trading market on which the Parent Stock is currently listed or quoted. The issuance and sale of the Shares under this Agreement does not contravene the rules and regulations of the trading market on which the Parent Stock is currently listed or quoted, and no approval of the Shareholders of Parent is required for Parent to issue and deliver to the Shareholders the Shares contemplated by this Agreement.
SECTION 4.27. No Undisclosed Events, Liabilities, Developments or Circumstances . No event, liability, development or circumstance has occurred or exists, or is contemplated to occur with respect to Parent, its subsidiaries or their respective business, properties, prospects, operations or financial condition, that would be required to be disclosed by Parent under applicable securities laws on a registration statement on Form S-1 filed with the SEC relating to an issuance and sale by Parent of the Parent Stock and which has not been publicly announced.
SECTION 4.28. Trading . Parent Stock is currently quoted for trading on the Over-the-Counter Bulletin Board, and Parent has received no notice that it is subject to being delisted therefrom.
ARTICLE V
DELIVERIES
SECTION 5.01. Deliveries of the Shareholder Representative .
(a) Concurrently herewith, the Shareholder Representative is delivering to Parent
(i) this Agreement executed by the Shareholder Representative together with the Company Disclosure Schedule;
(ii) certificates representing its Company Stock; and
(iii) documentation executed by the Shareholder Representative necessary to effect the transfer of the Company Stock held by the Shareholders to Parent.
SECTION 5.02. Deliveries of Parent .
(a) Concurrently herewith, Parent is delivering:

 

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(i) to the Shareholder Representative and to the Company, a copy of this Agreement executed by Parent, together with the Parent Disclosure Schedule;
(ii) to the Company, a certificate from Parent, signed by its Secretary or Assistant Secretary certifying that the attached copies of the Parent Charter, Parent Bylaws and resolutions of the Board of Directors of Parent approving the Agreement and the Transactions are all true, complete and correct and remain in full force and effect;
(iii) to the Company, a written consent of the Board of Directors authorizing and approving (1) the amendment of the Parent Charter to change Parent’s name to “International Stem Cell Corporation” and increasing the total number of authorized shares of Parent Stock to 220,000,000 shares; (2) the amendment of the Parent Bylaws; and (3) the adoption of a Stock Option Plan, approved by the Company;
(iv) to the Company, in connection with the matters set froth in Section 5.02(a)(iii) hereof, a duly executed Information Statement on Schedule 14C (the “ Information Statement ”) which shall be filed prior to the Form 8-K related to the Transactions;
(v) to the Company, evidence of the appointment of Kenneth Aldrich as the Chairman of the Board of Directors of Parent and election of each of Jeff Krstich, as the Chief Executive Officer; Jeffery Janus as the President and William B. Adams as the Chief Financial Officer of Parent, effective upon execution of this Agreement by Parent;
(vi) to the Company, a letter of resignation executed by Timothy Halter providing that Mr. Halter shall resign from the Board of Directors effective upon the tenth day after the mailing of the Schedule 14f-1;
(vii) to the Company, an irrevocable letter of instruction to the transfer agent for the Parent Stock instructing such transfer agent to issue new shares of Parent Stock issued to such Shareholders as set forth on Exhibit A attached hereto, in book-entry form. It being understood that as a result of the name change and the related change in CUSIP Number, the share certificates representing the Shares shall not be issued until the name change of Parent is effective;
(viii) to the Company, the SEC Edgar Filing Codes for Parent; and
(ix) to the Company, a certificate from Parent, signed by its authorized officer certifying that the representations and warranties contained in Article IV of this Agreement are true and accurate in all material respects, as of the date hereof, with the same effect as though expressly made at the Closing, and that Parent has performed in all material respects all agreements and covenants and complied in all material respects with all conditions contained in this Agreement, as of the date hereof.

 

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SECTION 5.03. Deliveries of the Company .
(a) Concurrently herewith, the Company is delivering to Parent:
(i) this Agreement executed by Company;
(ii) a certificate from the Company, signed by its authorized officer certifying that the attached copies of the Company Charter Documents and resolutions of the Board of Directors of the Company approving the Agreement and the Transactions are all true, complete and correct and remain in full force and effect; and
(iii) a certificate from the Company, signed by its authorized officer certifying that the representation and warranties contained in Article III hereof are true and accurate in all material respects, as of the date hereof, with the same effect as though expressly made at the Closing, and that the Company has performed in all material respects all agreements and covenants and complied in all material respects with all conditions contained in the Agreement, as of the date hereof.
SECTION 5.04. Deliveries of the Stockholder .
(a) Concurrently herewith, the Stockholder is delivering to the Company:
(i) this Agreement executed by the Stockholder;
(ii) a written consent authorizing and approving (1) the amendment of the Parent Charter to change of Parent’s name to “International Stem Cell, Inc.” and increasing the total number of authorized shares of Parent Stock to 200,000,000 shares; (2) the amendment of the Parent Bylaws; and (3) the adoption of a Stock Option Plan, approved by the Company.
ARTICLE VI
CONDITIONS TO CLOSING
SECTION 6.01. Stockholder and Company Conditions Precedent . The obligations of the Shareholders and the Company to enter into this Agreement and complete the Closing is subject, at the option of the Shareholders and the Company, to the fulfillment on or prior to the Closing Date of the following conditions.
(a) Representations and Covenants . The representations and warranties of Parent contained in this Agreement shall be true in all material respects on and as of the Closing Date with the same force and effect as though made on and as of the Closing Date. Parent shall have performed and complied in all material respects with all covenants and agreements required by this Agreement to be performed or complied with by Parent on or prior to the Closing Date. Parent shall have delivered to the Shareholders and the Company, a certificate, dated the Closing Date, to the foregoing effect.
(b) Litigation . No action, suit or proceeding shall have been instituted before any court or governmental or regulatory body or instituted or threatened by any governmental or regulatory body to restrain, modify or prevent the carrying out of the Transactions or to seek damages or a discovery order in connection with such Transactions, or which has or may have, in the reasonable opinion of the Company or any Shareholders, a materially adverse effect on the assets, properties, business, operations or condition (financial or otherwise) of Parent or the Company.

 

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(c) No Material Adverse Change . There shall not have been any occurrence, event, incident, action, failure to act, or transaction since December 31, 2005 which has had or is reasonably likely to cause a Parent Material Adverse Effect.
(d) Post-Closing Capitalization . At, and immediately after, the Closing, the authorized capitalization, and the number of issued and outstanding shares of the capital stock of the Company and Parent, on a fully-diluted basis, shall be as specified in Schedule 6.01(d) attached hereto.
(e) SEC Reports . Parent shall have filed all reports and other documents required to be filed by Parent under the U.S. federal securities laws through the Closing Date.
(f) OTCBB Quotation . Parent shall have maintained its status as a company whose common stock is quoted on the Over-the-Counter Bulletin Board and no reason shall exist as to why such status shall not continue immediately following the Closing.
(g) Deliveries of Parent . The deliveries specified in Section 5.02 shall have been made by Parent.
(h) Deliveries of the Stockholder . The deliveries specified in Section 5.04 shall have been made by the Stockholder.
(i) No Suspensions of Trading in Parent Stock; Listing . Trading in the Parent Stock shall not have been suspended by the SEC or any trading market (except for any suspensions of trading of not more than one trading day solely to permit dissemination of material information regarding Parent) at any time since the date of execution of this Agreement, and the Parent Stock shall have been at all times since such date listed for trading on a trading market.
SECTION 6.02. Parent Conditions Precedent . The obligations of Parent to enter into and complete the Closing is subject, at the option of Parent, to the fulfillment on or prior to the Closing Date of the following conditions, any one or more of which may be waived by Parent in writing.
(a) Representations and Covenants . The representations and warranties of the Shareholders and the Company contained in this Agreement shall be true in all material respects on and as of the Closing Date with the same force and effect as though made on and as of the Closing Date. The Shareholders and the Company shall have performed and complied in all material respects with all covenants and agreements required by this Agreement to be performed or complied with by the Shareholders and the Company on or prior to the Closing Date. The Company shall have delivered to Parent, if requested, a certificate, dated the Closing Date, to the foregoing effect.
(b) Litigation . No action, suit or proceeding shall have been instituted before any court or governmental or regulatory body or instituted or threatened by any governmental or regulatory body to restrain, modify or prevent the carrying out of the Transactions or to seek damages or a discovery order in connection with such Transactions, or which has or may have, in the reasonable opinion of Parent, a materially adverse effect on the assets, properties, business, operations or condition (financial or otherwise) of Parent.

 

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(c) No Material Adverse Change . There shall not have been any occurrence, event, incident, action, failure to act, or transaction since December 31, 2005 which has had or is reasonably likely to cause a Company Material Adverse Effect.
(d) Deliveries . The deliveries specified in Section 5.01 and Section 5.03 shall have been made by the Shareholder Representative and the Company, respectively.
(e) Audited Financial Statements and Form 10 Disclosure . The Company shall have provided Parent and the Shareholders with reasonable assurances that Parent will be able to comply with its obligation to file a current report on Form 8-K within one (1) business days following the Closing containing the requisite audited consolidated financial statements of the Company and the requisite Form 10-type disclosure regarding the Company.
(f) Post-Closing Capitalization . At, and immediately after, the Closing, the authorized capitalization, and the number of issued and outstanding shares of the capital stock of the Company and Parent, on a fully-diluted basis, shall be as specified in Schedule 6.01(d ) attached hereto.
ARTICLE VII
COVENANTS
SECTION 7.01. Preparation of the 14f-1 Notice; Information Statement; Blue Sky Laws .
(a) As soon as possible following the date of this Agreement and in any event, within one business day hereafter, the Company and Parent shall prepare and file with the SEC the 14f-1 Notice in connection with the consummation of this Agreement. Parent shall cause the 14f-1 Notice to be mailed to the Parent’s stockholders as promptly as practicable thereafter.
(b) As soon as possible following the date of this Agreement and in any event, within one business day hereafter, the Company and Parent shall prepare and file with the SEC the Information Statement on Schedule 14C in connection with the matters set forth in Sections 5.02(a)(iii) and 5.04(b) of this Agreement. Parent shall cause the 14f-1 Notice together with the Information Statement to be mailed to Parent’s stockholders as promptly as practicable thereafter.
(c) Parent shall take any action (other than qualifying to do business in any jurisdiction in which it is not now so qualified) required to be taken under any applicable state securities laws in connection with the issuance of Parent Stock in connection with this Agreement.

 

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SECTION 7.02. Public Announcements . Parent and the Company will consult with each other before issuing, and provide each other the opportunity to review and comment upon, any press release or other public statements with respect to the Agreement and the Transactions and shall not issue any such press release or make any such public statement prior to such consultation, except as may be required by applicable Law, court process or by obligations pursuant to any listing agreement with any national securities exchange.
SECTION 7.03. Fees and Expenses . All fees and expenses incurred in connection with this Agreement shall be paid by the party incurring such fees or expenses, whether or not this Agreement is consummated.
SECTION 7.04. Continued Efforts . Each party hereto shall use commercially reasonable efforts to (i) take all action reasonably necessary to consummate the Transactions, and (ii) take such steps and do such acts as may be necessary to keep all of its representations and warranties true and correct as of the Closing Date with the same effect as if the same had been made, and this Agreement had been dated, as of the Closing Date.
SECTION 7.05. Conduct of Business . During the period from the date hereof through the Closing Date, Parent and the Company shall carry on their respective businesses in the ordinary and usual course consistent with past practice.
SECTION 7.06. Exclusivity . Parent shall not (i) solicit, initiate, or encourage the submission of any proposal or offer from any person relating to the acquisition of any capital stock or other voting securities of Parent, or any assets of Parent (including any acquisition structured as a merger, consolidation, share exchange or other business combination), (ii) participate in any discussions or negotiations regarding, furnish any information with respect to, assist or participate in, or facilitate in any other manner any effort or attempt by any person to do or seek any of the foregoing, or (iii) take any other action that is inconsistent with the Transactions and that has the effect of avoiding the Closing contemplated hereby. Parent shall notify the Company immediately if any person makes any proposal, offer, inquiry, or contact with respect to any of the foregoing.
SECTION 7.07. Filing of 8-K and Press Release . Parent shall file, within one business day of the Closing Date, a current report on Form 8-K and attach as exhibits all relevant agreements with the SEC disclosing the terms of this Agreement and other requisite disclosure regarding the Transactions and including the requisite audited consolidated financial statements of the Company and the requisite Form 10 disclosure regarding the Company. In addition, Parent shall issue a press release prior to 9:30 a.m. (New York Time) on the business day following the Closing Date, announcing the closing of the Transactions.
SECTION 7.08. Furnishing of Information . As long as the Stockholder owns the Shares, Parent covenants to timely file (or obtain extensions in respect thereof and file within the applicable grace period) all reports required to be filed by Parent after the date hereof pursuant to the Exchange Act. As long the Stockholder owns Shares, if Parent is not required to file reports pursuant to such laws, it will prepare and furnish to the Stockholder and make publicly available in accordance with Rule 144(c) promulgated by the SEC pursuant to the Securities Act, such information as is required for the Stockholder to sell the Shares under Rule 144. Parent further covenants that it will take such further action as any holder of Shares may reasonably request, all to the extent required from time to time to enable such person to sell the Shares without registration under the Securities Act within the limitation of the exemptions provided by Rule 144.

 

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SECTION 7.09. Integration . The Company shall not, and shall use its best efforts to ensure that no affiliate of the Company shall, sell, offer for sale or solicit offers to buy or otherwise negotiate in respect of any security (as defined in Section 2 of the Securities Act) that would be integrated with the offer or sale of the Shares in a manner that would require the registration under the Securities Act of the acquisition of the Shares by the Shareholders pursuant to the Agreement, or that would be integrated with the offer or sale of the Shares for purposes of the rules and regulations of any trading market in a manner that would require stockholder approval of the sale of the securities to the Shareholders.
SECTION 7.10. Limitation on Issuance of Future Priced Securities . During the six months following the Closing, Parent shall not issue any “Future Priced Securities” as such term is described by NASD IM-4350-1.
SECTION 7.11. Non-Public Information . Each of the Company and Parent covenant and agree that neither it nor any other person acting on their behalf will provide any person information that the Company or Parent believes constitutes material non-public information, unless prior thereto such person shall have executed a written agreement regarding the confidentiality and use of such information. Each of the Company and Parent understands and confirms that each Shareholder shall be relying on the foregoing representations in effecting transactions in securities of Parent.
SECTION 7.12. Listing of Securities . Parent agrees, (i) if Parent applies to have the Parent Stock traded on any other trading market, it will include in such application the Shares, and will take such other action as is necessary or desirable to cause the Shares to be listed on such other trading market as promptly as possible, and (ii) it will take all action reasonably necessary to continue the listing and trading of Parent Stock on a trading market and will comply in all material respects with Parent’s reporting, filing and other obligations under the bylaws or rules of the trading market.
ARTICLE VIII
INDEMNIFICATION
SECTION 8.01. Indemnification of Company and the Shareholders . Each of Parent and the Stockholder shall indemnify and hold the Company and each of the Shareholders and their directors, officers, shareholders, partners, employees and agents (each, a “ Company Indemnified Party ”) harmless from any and all losses, liabilities, obligations, claims, contingencies, damages, costs and expenses, including all judgments, amounts paid in settlements, court costs and reasonable attorneys’ fees and costs of investigation (collectively, “ Losses ”) that any such Company Indemnified Party may suffer or incur as a result of or relating to any misrepresentation, breach or inaccuracy of any representation, warranty, covenant or agreement made by Parent or the Stockholder in this Agreement or any of the documents

 

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contemplated herein. In addition to the indemnity contained herein, Parent will reimburse each Company Indemnified Party for its reasonable legal and other expenses (including the cost of any investigation, preparation and travel in connection therewith) incurred in connection therewith, as such expenses are incurred.
SECTION 8.02. Indemnification of Parent and the Stockholder . The Company shall indemnify and hold Parent and the Stockholder and their directors, officers, shareholders, partners, employees and agents (each, an “ Parent Indemnified Party ”) harmless from any and all Losses that any such Parent Indemnified Party may suffer or incur as a result of or relating to any misrepresentation, breach or inaccuracy of any representation, warranty, covenant or agreement made by the Company in this Agreement or any of the documents contemplated herein
SECTION 8.03. Indemnification Procedure . A party (an “ Indemnified Party ”) seeking indemnification shall give prompt notice to the other party (the “ Indemnifying Party ”) of any claim for indemnification arising under this Article VIII. The Indemnifying Party shall have the right to assume and to control the defense of any such claim with counsel reasonably acceptable to such Indemnified Party, at the Indemnifying Party’s own cost and expense, including the cost and expense of reasonable attorneys’ fees and disbursements in connection with such defense, in which event the Indemnifying Party shall not be obligated to pay the fees and disbursements of separate counsel for such in such action. In the event, however, that such Indemnified Party’s legal counsel shall determine that defenses may be available to such Indemnified Party that are different from or in addition to those available to the Indemnifying Party, in that there could reasonably be expected to be a conflict of interest if such Indemnifying Party and the Indemnified Party have common counsel in any such proceeding, or if the Indemnified Party has not assumed the defense of the action or proceedings, then such Indemnifying Party may employ separate counsel to represent or defend such Indemnified Party, and the Indemnifying Party shall pay the reasonable fees and disbursements of counsel for such Indemnified Party. No settlement of any such claim or payment in connection with any such settlement shall be made without the prior consent of the Indemnifying Party which consent shall not be unreasonably withheld.
ARTICLE IX
MISCELLANEOUS
SECTION 9.01. Notices . All notices, requests, claims, demands and other communications under this Agreement shall be in writing and shall be deemed given upon receipt by the parties at the following addresses (or at such other address for a party as shall be specified by like notice):
If to Parent, to:
BTHC III, Inc.
12890 Hilltop Road
Argyle, Texas 76226
Attention: Timothy Halter
Facsimile: (972) 233-0300

 

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If to the Company or the Shareholder Representative, to:
International Stem Cell Corporation
2595 Jason Court
Oceanside, California 92056
Attention: Jeff Krstich
Facsimile: (760) 940-6387
with a copy to:
Katten Muchin Rosenman, LLP
2029 Century Park East, Suite 2600
Los Angeles, California 90067
Attention: Eric A. Klein
Facsimile: (310) 712-8234
SECTION 9.02. Amendments; Waivers; No Additional Consideration . No provision of this Agreement may be waived or amended except in a written instrument signed by the Company, Parent and the Shareholders holding a majority of the Shares. No waiver of any default with respect to any provision, condition or requirement of this Agreement shall be deemed to be a continuing waiver in the future or a waiver of any subsequent default or a waiver of any other provision, condition or requirement hereof, nor shall any delay or omission of either party to exercise any right hereunder in any manner impair the exercise of any such right. No consideration shall be offered or paid to any Shareholder to amend or consent to a waiver or modification of any provision of any transaction document unless the same consideration is also offered to all Shareholders who then hold Shares.
SECTION 9.03. Replacement of Securities . If any certificate or instrument evidencing any Shares is mutilated, lost, stolen or destroyed, Parent shall issue or cause to be issued in exchange and substitution for and upon cancellation thereof, or in lieu of and substitution therefor, a new certificate or instrument, but only upon receipt of evidence reasonably satisfactory to Parent of such loss, theft or destruction and customary and reasonable indemnity, if requested. The applicants for a new certificate or instrument under such circumstances shall also pay any reasonable third-party costs associated with the issuance of such replacement Shares. If a replacement certificate or instrument evidencing any Shares is requested due to a mutilation thereof, Parent may require delivery of such mutilated certificate or instrument as a condition precedent to any issuance of a replacement.
SECTION 9.04. Remedies . In addition to being entitled to exercise all rights provided herein or granted by law, including recovery of damages, each of the Shareholders, Parent and the Company will be entitled to specific performance under this Agreement. The parties agree that monetary damages may not be adequate compensation for any loss incurred by reason of any breach of obligations described in the foregoing sentence and hereby agrees to waive in any action for specific performance of any such obligation the defense that a remedy at law would be adequate.

 

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SECTION 9.05. Independent Nature of Shareholders’ Obligations and Rights . The obligations of each Shareholder under this Agreement are several and not joint with the obligations of any other Shareholder, and no Shareholder shall be responsible in any way for the performance of the obligations of any other Shareholder under this Agreement. The decision of each Shareholder to acquire Shares pursuant to this Agreement was been made by such Shareholder independently of any other Shareholder. Nothing contained herein, and no action taken by any Shareholder pursuant hereto, shall be deemed to constitute the Shareholders as a partnership, an association, a joint venture or any other kind of entity, or create a presumption that the Shareholders are in any way acting in concert or as a group with respect to such obligations or the transactions contemplated herein. Each Shareholder shall be entitled to independently protect and enforce its rights, including without limitation the rights arising out of this Agreement, and it shall not be necessary for any other Shareholder to be joined as an additional party in any proceeding for such purpose.
SECTION 9.06. Limitation of Liability . Notwithstanding anything herein to the contrary, each of Parent and the Company acknowledge and agree that the liability of a Shareholder arising directly or indirectly, under any transaction document of any and every nature whatsoever shall be satisfied solely out of the assets of such Shareholder, and that no trustee, officer, other investment vehicle or any other affiliate of such Shareholder or any investor, shareholder or holder of shares of beneficial interest of such Shareholder shall be personally liable for any liabilities of such Shareholder.
SECTION 9.07. Interpretation; Disclosure Letters . When a reference is made in this Agreement to a Section, such reference shall be to a Section of this Agreement unless otherwise indicated. Whenever the words “include”, “includes” or “including” are used in this Agreement, they shall be deemed to be followed by the words “without limitation”.
SECTION 9.08. Severability . If any term or other provision of this Agreement is invalid, illegal or incapable of being enforced by any rule or Law, or public policy, all other conditions and provisions of this Agreement shall nevertheless remain in full force and effect so long as the economic or legal substance of the Transactions contemplated hereby is not affected in any manner materially adverse to any party. Upon such determination that any term or other provision is invalid, illegal or incapable of being enforced, the parties hereto shall negotiate in good faith to modify this Agreement so as to effect the original intent of the parties as closely as possible in an acceptable manner to the end that Transactions contemplated hereby are fulfilled to the extent possible.
SECTION 9.09. Counterparts; Facsimile Execution . This Agreement may be executed in one or more counterparts, all of which shall be considered one and the same agreement and shall become effective when one or more counterparts have been signed by each of the parties and delivered to the other parties. Facsimile execution and delivery of this Agreement is legal, valid and binding for all purposes.
SECTION 9.10. Entire Agreement; Third Party Beneficiaries . This Agreement, taken together with the Company Disclosure Schedule, the Parent Disclosure Schedule and the exhibits and schedules attached hereto, (i) constitute the entire agreement, and supersede all prior agreements and understandings, both written and oral, among the parties with respect to the Transactions and (ii) are not intended to confer upon any person other than the parties any rights or remedies.

 

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SECTION 9.11. Governing Law . This Agreement shall be governed by, and construed in accordance with, the laws of the State of California, regardless of the laws that might otherwise govern under applicable principles of conflicts of laws thereof.
SECTION 9.12. Assignment . Neither this Agreement nor any of the rights, interests or obligations under this Agreement shall be assigned, in whole or in part, by operation of law or otherwise by any of the parties without the prior written consent of the other parties. Any purported assignment without such consent shall be void. Subject to the preceding sentences, this Agreement will be binding upon, inure to the benefit of, and be enforceable by, the parties and their respective successors and assigns.
[ Signature Page Follows ]

 

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The parties hereto have executed and delivered this Share Exchange Agreement as of the date first above written.
Parent:
             
    BTHC III, INC., a Delaware corporation
 
           
 
  By:        
 
     
 
Name: Timothy Halter
   
 
      Title: CEO and President    
The Stockholder:
             
    HALTER FINANCIAL INVESTMENTS, L.P.,
    a Texas limited partnership
 
           
    By:   Halter Financial Investments, GP, LLC,
 
      the general partner    
 
           
 
  By:        
 
     
 
Name: Timothy Halter
   
 
      Title: Member    
The Company:
             
    INTERNATIONAL STEM CELL CORPORATION,    
    a California corporation    
 
           
 
  By:        
 
     
 
Name: Jeff Krstich
   
 
      Title: Chief Executive Officer    
The Shareholder Representative:
         
 
 
 
Name: Kenneth Aldrich
   
[ Signature Page to Share Exchange Agreement ]

 

 

 

EXHIBIT 4.1
THIS WARRANT AND THE SECURITIES ISSUABLE UPON THE EXERCISE HEREOF HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “1933 ACT”), AND MAY NOT BE SOLD, TRANSFERRED, ASSIGNED OR HYPOTHECATED EXCEPT PURSUANT TO AN EFFECTIVE REGISTRATION STATEMENT UNDER THE 1933 ACT COVERING SUCH SECURITIES OR IF THE COMPANY RECEIVES AN OPINION OF COUNSEL FOR THE HOLDER OF THESE SECURITIES REASONABLY SATISFACTORY TO THE COMPANY, STATING THAT SUCH SALE, TRANSFER, ASSIGNMENT OR HYPOTHECATION IS EXEMPT FROM THE REGISTRATION AND PROSPECTUS DELIVERY REQUIREMENTS OF THE 1933 ACT.
WARRANT
of
Lifeline Cell Technologies, LLC
________, 2006
THIS CERTIFIES THAT, for value received,___(the “Holder”) has purchased and is the holder of a Warrant to purchase the number of shares of Membership Interest of Lifeline Cell Technologies, LLC, a California LLC (“ Lifeline “), or shares of any corporation for which such shares of Lifeline may be exchanged as set forth in Section 1.2 hereof as could be purchased for $ ___,000.00, subject to the terms and conditions set forth herein.
1.  Exercise of Warrant . The terms and conditions upon which this Warrant may be exercised, and the Stock may be purchased, are as follows:
  1.1  
Term . Subject to the terms hereof, this Warrant shall be exercisable in whole or in part at any time. This Warrant shall expire on June 1, 2009 (the “Expiration Date”).
  1.2  
Securities Issuable Upon Exercise. Each Warrant shall, upon exercise, entitle the holder to receive the number and class of securities described as follows:
  1.2.1  
If the shareholders of Lifeline have received shares of stock in a corporation in exchange for Lifeline shares of Membership Interest (or pursuant to other corporate merger or consolidation) pursuant to which Lifeline is merged into or becomes a subsidiary of a public corporation in connection with a financing arrangement generating at least $2 million of operating capital for Lifeline, each Warrant shall entitle the holder thereof to purchase the number of shares of Common Stock that could be purchased by the dollar amount of the Warrant being exercised at the offering price of the shares sold in the offering (or at the conversion price if the offering is of a convertible security) at a price equal to 80% of the purchase price paid by the investors in such offering. By way of example, if the stock were issued at $1.00 per share (or if the conversion price of a convertible security were $1.00 per share), a Warrant with a face value of $100 would entitle the investor to purchase 100 shares for $80. Fractional shares shall be rounded to the next whole number.

 

 


 

  1.2.2  
If on or prior to April 1, 2007 Lifeline shall not have consummated an exchange of shares or other merger or consolidation as described in section 1.2.1 but shall obtain public or private financing of at least $1,000,000 within the following 12 months, each Warrant shall entitle the holder thereof to purchase the amount of securities that could be purchased by the dollar amount of the Warrant being exercised at the offering price in the offering (or at the conversion price if the offering is of a convertible security) at a price equal to 80% of the purchase price paid by the investors in such offering. Fractional shares shall be rounded to the next whole number.
  1.2.3  
If on or prior to April 1, 2008 no additional public or private financing has been obtained, each Warrant shall entitle the holder thereof to purchase the amount of Class B Membership interests in Lifeline as could have been purchased by the dollar amount of the Warrant being exercised at the price paid by the purchasers of such Class B Membership interests.
  1.3  
Method of Exercise . The exercise of the purchase rights evidenced by this Warrant shall be effected by (i) the surrender of this Warrant, together with a duly executed copy of the form of subscription attached hereto as Schedule A , to the Company at its principal offices and (ii) the delivery of the purchase price by check or bank draft payable to the Company’s order or by wire transfer of same day funds to the Company’s account for the number of shares for which the purchase rights hereunder are being exercised. The exercise of this Warrant shall be deemed to have been effected immediately prior to the close of business on the day on which this Warrant shall have been surrendered to the Company as provided herein or at such later date as may be specified in the executed form of subscription, and at such time, the person or persons in whose name or names any certificate or certificates for shares of stock shall be issuable upon such exercise, as provided herein, shall be deemed to have become the holder or holders of record thereof.
  1.4  
Net Exercise . At the election of the Holder and at any time during which this Warrant may be exercised pursuant to its terms, the Holder, in lieu of the payment in cash of the Exercise Price following delivery to the Corporation of a Notice of Exercise under Section 1.3 , may elect to undertake a Net Exercise of this Warrant to such extent as the Holder may determine. A “ Net Exercise ” shall mean that the Corporation, in lieu of receiving a cash payment of the Exercise Price for each Warrant Share, shall issue a number of Warrant Shares computed using the following formula:

 

 


 

             
 
          x = [y times (a-b)] divided by a
 
           
where
  x   =   the number of Warrant Shares to be issued to the Holder
 
  y   =   the number of Warrant Shares purchasable under this Warrant (at the date of such calculation)
 
  a   =   the Fair Market Value of one (1) Warrant Share (at the date of such calculation)
 
  b   =   the Exercise Price (as adjusted to the date of such calculation)
 
           
For example, if this Warrant were exercisable for fifty thousand (50,000) Warrant Shares, the Fair Market Value of one (1) Warrant Share were Four Dollars ($4.00) at the time of such Net Exercise, and the Exercise Price were One Dollar ($1.00), then the Corporation would issue that number of Warrant Shares calculated as follows:
 
           
 
  x   =   [50,000 times ($4.00 – $1.00)] divided by $4.00
 
           
 
  x   =   37,500 shares
2.  Adjustments to Exercise Price . The number and kind of shares of Stock issuable upon the exercise of this Warrant and the exercise price hereunder shall be subject to adjustment from time to time upon the happening of certain events, as follows:
2.1 Splits and Subdivisions . If the Company should at any time or from time to time fix a record date for the effectuation of a split or subdivision of the outstanding shares of Membership Interest or shares of stock received in exchange for such Membership Interests (the “Stock” for purposes hereof) or the determination of the holders of Stock entitled to receive a dividend or other distribution payable in additional shares of Stock or other securities or rights convertible into, or entitling the holder thereof to receive directly or indirectly, additional shares of Stock (hereinafter referred to as the “Stock Equivalents”) without payment of any consideration by such holder for the additional shares of Stock or Stock Equivalents, then, as of such record date (or the date of such distribution, split or subdivision if no record date is fixed), the Exercise Price shall be appropriately decreased and the number of shares of Stock which this Warrant are exercisable for, if any, shall be appropriately increased in proportion to such increase of outstanding shares.
2.2 Combination of Shares . If the number of shares of Stock outstanding at any time after the date hereof is decreased by a reverse stock split or other combination of the outstanding shares of Stock, the Exercise Price shall be appropriately increased and the number of shares of Stock which this Warrant are exercisable for shall be appropriately decreased in proportion to such decrease in outstanding shares.

 

 


 

2.3 Mergers, Consolidation or Sale of Assets . If at any time or from time to time there shall be a capital reorganization of the Stock (other than a subdivision, combination, reclassification or exchange of shares provided for elsewhere in this Section 2 ) or a merger or consolidation of the Company with or into another corporation, or the sale of all or substantially all of the Company’s assets to any other person or entity, then as a part of such reorganization, merger, consolidation or sale, provision shall be made, in form and substance reasonably acceptable to the Holder, so that the Holder shall thereafter be entitled to receive upon the exercise of this Warrant (or a Warrant in form and substance satisfactory to the Holder issued in replacement hereof), the number of shares of capital stock or other securities or property of the Company, or of the successor corporation resulting from such reorganization, merger, consolidation or sale, to which a holder of the number of shares of Stock (or any shares of stock or other securities which may be) issuable upon the exercise of this Warrant would have received if this Warrant had been exercised in full immediately prior to such reorganization, merger, consolidation or sale, all subject to further adjustment as provided herein. The provisions of this Section 2.3 shall similarly apply to successive reorganizations, consolidations, mergers and sales.
2.4 Adjustments for Other Distributions . In the event the Company shall declare a distribution payable in securities of other persons or entities, evidences of indebtedness issued by the Company or other persons, assets (excluding regular cash dividends) or options or rights not referred to in Section 2.1 with respect to the Stock, then, in each such case for the purpose of this Section 2.4 , upon exercise of this Warrant the Holder shall be entitled to a proportionate share of any such distribution as though such Holder was the holder of the number of shares of Stock of the Company into which this Warrant may be exercised as of the record date fixed for the determination of the holders of Stock of the Company entitled to receive such distribution, all subject to further adjustment as provided herein.
2.5 Reclassification or Reorganization . If the Stock (or any shares of stock or other securities) which may be issuable upon the exercise of this Warrant shall be changed into the same or different number of shares of any class or classes of capital stock, whether by capital reorganization, reclassification or otherwise (other than a subdivision or combination of shares or stock dividend provided for in Sections 2.1 , 2.2 and 2.4 above, or a reorganization, merger, consolidation or sale of assets provided for in Section 2.3 above), then and in each such event the Holder shall be entitled to receive upon the exercise of this Warrant the kind and amount of shares of capital stock and other securities and property receivable upon such reorganization, reclassification or other change, to which a holder of the number of shares of Stock (or any shares of stock or other securities which may be) issuable upon the exercise of this Warrant would have received if this Warrant had been exercised immediately prior to such reorganization, reclassification or other change, all subject to further adjustment as provided herein.
2.6 Notice of Adjustments and Record Dates . The Company shall promptly notify the Holder in writing of each adjustment or readjustment of the Exercise Price hereunder and the number of shares of Stock issuable upon the exercise of this Warrant. Such notice shall state the adjustment or readjustment and show in reasonable detail the facts on which that adjustment or readjustment is based.

 

 


 

2.7 No Impairment . The Company shall not avoid or seek to avoid the observance or performance of any of the terms to be observed or performed hereunder by the Company, but shall at all times in good faith assist in the carrying out of all the provisions of this Warrant. Without limiting the generality of the foregoing, the Company (a) shall at all times reserve and keep available a number of its authorized shares of Stock, free from all preemptive rights therein, which shall be sufficient to permit the exercise of this Warrant and (b) shall take all such action as may be necessary or appropriate in order that all shares of Stock as may be issued pursuant to the exercise of this Warrant shall, upon issuance, be duly and validly issued, fully paid and nonassessable and free from all taxes, liens and charges with respect to the issue thereof.
2.8 Priorities Preserved. This provisions of this Section 2 shall not apply to adjustments made to preserve the economic value of preferences held by the holders of Class A or Class B Membership Interests in Lifeline in connection with any share exchange, merger or consolidation of Lifeline as described in Section 1 hereof.
3.  Replacement of the Warrant . On receipt by the Company of evidence reasonably satisfactory to the Company of the loss, theft, destruction or mutilation of this Warrant and, in the case of any such loss, theft or destruction of this Warrant, on delivery of an indemnity agreement reasonably satisfactory in form to the Company or, in the case of any such mutilation, on surrender and cancellation of the Warrant, the Company at its expense shall execute and deliver to the Holder, in lieu thereof, a new Warrant of like tenor.
4.  No Rights or Liability as a Stockholder . This Warrant does not entitle the Holder hereof to any voting rights or other rights as a stockholder of the Company. No provisions hereof, in the absence of affirmative action by the Holder to purchase Stock, and no enumeration herein of the rights or privileges of the Holder, shall give rise to any liability of the Holder as a stockholder of the Company.
5.  Miscellaneous .
5.1 Compliance with Securities Laws . The Holder of this Warrant, by acceptance hereof, acknowledges that (i) it is an “accredited investor” as that term is defined in Rule 501(a) of Regulation D under the Securities Act of 1933, as amended (the “Securities Act”); (ii) it has knowledge and experience in financial and business matters such that it is capable of evaluating the merits and risks of acquiring this Warrant; (iii) it is acquiring this Warrant and the shares of Stock to be issued upon exercise hereof solely for its own account, not as a nominee or agent, and not with a view to, or for resale in connection with, any distribution thereof, and that it will not offer, sell or otherwise dispose of this Warrant or any shares of Stock to be issued upon exercise hereof or conversion thereof except under circumstances that will not result in a violation of the Securities Act or any applicable state securities laws; (iv) it understands that no public market now exists for this Warrant, or for the shares of Stock to be issued upon exercise thereof, and that the Company has made no assurances that a public market will ever exist for this Warrant or any shares so issued; (v) it has had an opportunity to discuss the tax consequences of its acquisition of this Warrant with its own tax advisor, that it is relying solely on such advisors and not on any statements or representations of the Company or any of the Company’s agents with respect to such tax consequences, and that it understands that it, and not the Company, shall be responsible for its own tax liability that may arise as a result of its acquisition of this Warrant; and (vi) the Holder either has a preexisting personal or business relationship with the Company, its officers or its directors or, by reason of its business or financial experience, or the business or financial experience of its professional advisors (being unaffiliated with and not compensated by the Company or any affiliate or selling agent of the Company) can reasonably be assumed to have the capacity to protect its interests in connection with its acquisition of the Warrant.

 

 


 

5.2 Transfer of Warrant . This Warrant and the shares of Stock issued upon the exercise of this Warrant (the “Securities”) shall be transferable or assignable by the Holder so long as such transfer is made in compliance with applicable securities laws and as set forth below. Prior to any proposed sale, assignment, transfer or pledge of any Securities, unless there is in effect a registration statement under the Securities Act covering the proposed transfer, the Holder shall give written notice to the Company of the Holder’s intention to effect such transfer, sale, assignment or pledge. Each such notice shall describe the manner and circumstances of the proposed transfer, sale, assignment or pledge in sufficient detail, and, if requested by the Company, the Holder shall also provide, at the Holder’s expense, either (i) a written opinion addressed to the Company of legal counsel who shall be, and whose legal opinion shall be, reasonably satisfactory to the Company, to the effect that the proposed transfer of the Securities may be effected without registration under the Securities Act, or (ii) a “no action” letter from the Securities and Exchange Commission (the “Commission”) to the effect that the transfer of such securities without registration will not result in a recommendation by the staff of the Commission that action be taken with respect thereto, whereupon the Holder shall be entitled to transfer such Securities in accordance with the terms of the notice delivered by the holder to the Company; provided, however, that the Company shall not request an opinion of counsel or “no action” letter with respect to (i) a transfer not involving a change in beneficial ownership, (ii) a transaction involving the distribution without consideration of the Securities by the holder to its constituent partners, members or beneficiaries in proportion to their ownership interests in the holder, or to the Settlor of a revocable trust (iii) a transaction involving the transfer without consideration of the Securities by an individual holder during such holder’s lifetime by way of gift or on death by will or intestacy or (iv) a transfer to an affiliate (as defined in Rule 405 of the Securities Act) of the Holder.
5.3 Lock-up. Provided that all holders of at least 1% of the outstanding securities of the Company and all officers and directors of the Company are also so bound, the Holder shall not, to the extent requested by any managing underwriter of the Company, sell or otherwise transfer or dispose of (other than to donees who agree to be similarly bound) any shares of Stock issued upon the exercise of this Warrant during a period (the “Stand-Off Period”) equal to (i) 180 days following the effective date of a registration statement for an initial public offering of the Company’s Stock for sale to the public and (ii) 120 days following the effective date of a registration statement of any secondary offering of the Company under the Securities Act (or in each case such shorter period as the Company or managing underwriter may authorize), and except in each case, for securities sold as part of any offerings covered by any registration statements in accordance with the provisions of the Registration Agreement. In order to enforce the foregoing covenant, the Company may impose stock transfer restrictions with respect to the shares of Stock issued upon the exercise of this Warrant until the end of the Stand-Off Period. Notwithstanding the foregoing, the obligations described in this Section 5.3 shall not apply to a registration relating solely to employee benefit plans on Form S-1 or Form S-8 or similar forms which may be promulgated in the future, or a registration relating solely to a Commission Rule 145 transaction on Form S-4 or similar forms which may be promulgated in the future.

 

 


 

5.4 Restrictive Legends. The certificates representing the Stock and any securities of the Company issued with respect thereto shall be imprinted with legends restricting transfer except in compliance with the terms hereof and with applicable Federal and state securities laws.
5.5 “Piggy Back” Registration. If at any time the Company shall determine to register under the Securities Act any of its Stock (other than a registration relating solely to the sale of securities on a form which does not include substantially the same information as would be required to be included in a registration statement covering the sale of the Holder’s Shares), it shall send to each Holder written notice of such determination and, if within twenty (20) days after receipt of such notice, such Holder shall so request in writing, the Company shall use its best efforts to include in such registration statement all or any part of the Holder’s Shares that such Holder requests to be registered. Notwithstanding the foregoing, if the managing underwriter shall impose a limitation on the number of shares of Stock included in any such registration statement because, in such underwriter’s judgment, such limitation is necessary based on market conditions, the Company may exclude, to the extent so advised by the underwriters, the Holder’s Shares from the underwriting; provided, however, that if the underwriters do not entirely exclude all shares issuable upon exercise of any other outstanding warrants to purchase Stock (the “Registrable Shares”) from such Initial Public Offering, the Company shall be obligated to include in such registration statement, with respect to the requesting Holder, an amount of Registrable Shares equal to the product of (i) the number of Registrable Shares that remain available for registration after the underwriter’s cut back and (ii) such Holder’s percentage ownership of all such securities.
5.6 Titles and Subtitles . The titles and subtitles used in this Warrant are for convenience only and are not to be considered in construing or interpreting this Warrant.
5.7 Notices . Except as otherwise provided herein, all notices under this warrant shall be in writing and shall be delivered by personal service, facsimile, courier service promising overnight delivery or certified mail (if such service is not available, then by first class mail), postage prepaid. Notices shall be addressed as follows:
If to the Company:
C/O Mr. William B. Adams
711 Linda Flora Drive
Los Angeles, CA 90049
 
Phone 310-472-3017
Fax 310-496-2850

 

 


 

If to the Holder:
With respect to any other Holder, such address as if provided by such Holder to the Company. Any party may change its address for the purpose of this Section 5.7 by giving the other party written notice of its new address in the manner set forth above.
5.8 Attorneys’ Fees . If any action at law or in equity is necessary to enforce or interpret the terms of this Warrant, the prevailing party shall be entitled to reasonable attorneys’ fees, costs and disbursements in addition to any other relief to which such party may be entitled.
5.9 Amendments and Waivers . Any term of this Warrant may be amended and the observance of any term of this Warrant may be waived (either generally or in a particular instance and either retroactively or prospectively), with the written consent of the Company and the Holder. Any amendment or waiver affected in accordance with this Section 5.9 shall be binding upon the Holder of this Warrant (and of any securities into which this Warrant are convertible), each future holder of all such securities, and the Company.
5.10 Severability . If one or more provisions of this Warrant are held to be unenforceable under applicable law, such provision shall be excluded from this Warrant and the balance of the Warrant shall be interpreted as if such provision were so excluded and shall be enforceable in accordance with its terms.
5.11 Governing Law . This Warrant shall be governed by and construed and enforced in accordance with the laws of the State of California, without giving effect to its conflicts of laws principles.
Signature page follows
         
  Lifeline Cell Technology, LLC
 
 
 
  By:   William B. Adams  
  Its: Managing Member   
       
 

 

 


 

SCHEDULE A
FORM OF SUBSCRIPTION
(To be signed only on exercise of Warrant)
To:  
Lifeline Cell Technology, LLC.
The undersigned, the holder of the Warrant attached hereto, hereby elects to exercise the purchase rights represented by such Warrant for, and to purchase thereunder, ___shares of Stock of Lifeline Cell Technology, LLC., or shares of any corporation for which such shares of Lifeline may be exchanged.
The undersigned elects one of the following:
  1.  
The undersigned has included herewith payment of $___representing the purchase price of such shares in full. OR
 
  2.  
The undersigned elects a “cashless exercise” as described in the warrant.
The undersigned elects 1.___or 2. ___, please initial.
Please issue a certificate for such shares be issued in the name of ___, and delivered to ___, whose address is ___ whose social security number/taxpayer identification number is ___.
The undersigned represents that the aforesaid shares are being acquired for the account of the undersigned for investment and not with a view to, or for resale in connection with, the distribution thereof and that the undersigned has no present intention of distributing or reselling such shares.
(Signature must conform in all respects to name of the Holder as specified on the face of the Warrant)
             
Dated:
           
 
           
 
          (Print Name)
 
           
 
           
 
           
 
           
 
      Address:    
 
           
 
           
 
           

 

 

 

EXHIBIT 4.2
THIS WARRANT AND THE SECURITIES ISSUABLE UPON THE EXERCISE HEREOF HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “1933 ACT”), AND MAY NOT BE SOLD, TRANSFERRED, ASSIGNED OR HYPOTHECATED EXCEPT PURSUANT TO AN EFFECTIVE REGISTRATION STATEMENT UNDER THE 1933 ACT COVERING SUCH SECURITIES OR IF THE COMPANY RECEIVES AN OPINION OF COUNSEL FOR THE HOLDER OF THESE SECURITIES REASONABLY SATISFACTORY TO THE COMPANY, STATING THAT SUCH SALE, TRANSFER, ASSIGNMENT OR HYPOTHECATION IS EXEMPT FROM THE REGISTRATION AND PROSPECTUS DELIVERY REQUIREMENTS OF THE 1933 ACT.
WARRANT
of
Lifeline Cell Technologies, LLC
May __, 2006
THIS CERTIFIES THAT, for value received, ___(the “Holder”) has purchased and is the holder of a Warrant to purchase the number of shares of Membership Interest of Lifeline Cell Technologies, LLC, a California LLC (“ Lifeline “), or shares of any corporation for which such shares of Lifeline may be exchanged as set forth in Section 1.2 hereof as could be purchased for $ ___, subject to the terms and conditions set forth herein.
1.  Exercise of Warrant . The terms and conditions upon which this Warrant may be exercised, and the Stock may be purchased, are as follows:
  1.1  
Term . Subject to the terms hereof, this Warrant shall be exercisable in whole or in part at any time. This Warrant shall expire on June 1, 2009 (the “Expiration Date”).
  1.2  
Securities Issuable Upon Exercise. Each Warrant shall, upon exercise, entitle the holder to receive the number and class of securities described as follows:
  1.2.1  
If the shareholders of Lifeline have received shares of stock in a corporation in exchange for Lifeline shares of Membership Interest (or pursuant to other corporate merger or consolidation) pursuant to which Lifeline is merged into or becomes a subsidiary of a public corporation in connection with a financing arrangement generating at least $2 million of operating capital for Lifeline, each Warrant shall entitle the holder thereof to purchase the number of shares of Common Stock that could be purchased by the dollar amount of the Warrant being exercised at the offering price of the shares sold in the offering (or at the conversion price if the offering is of a convertible security) at a price equal to 80% of the purchase price paid by the investors in such offering. By way of example, if the stock were issued at $1.00 per share (or if the conversion price of a convertible security were $1.00 per share), a Warrant with a face value of $100 would entitle the investor to purchase 100 shares for $80. Fractional shares shall be rounded to the next whole number.

 

 


 

  1.2.2  
If on or prior to April 1, 2007 Lifeline shall not have consummated an exchange of shares or other merger or consolidation as described in section 1.2.1 but shall obtain public or private financing of at least $1,000,000 within the following 12 months, each Warrant shall entitle the holder thereof to purchase the amount of securities that could be purchased by the dollar amount of the Warrant being exercised at the offering price in the offering (or at the conversion price if the offering is of a convertible security) at a price equal to 80% of the purchase price paid by the investors in such offering. Fractional shares shall be rounded to the next whole number.
  1.2.3  
If on or prior to April 1, 2008 no additional public or private financing has been obtained, each Warrant shall entitle the holder thereof to purchase the amount of Class B Membership interests in Lifeline as could have been purchased by the dollar amount of the Warrant being exercised at the price paid by the purchasers of such Class B Membership interests.
  1.3  
Method of Exercise . The exercise of the purchase rights evidenced by this Warrant shall be effected by (i) the surrender of this Warrant, together with a duly executed copy of the form of subscription attached hereto as Schedule A , to the Company at its principal offices and (ii) the delivery of the purchase price by check or bank draft payable to the Company’s order or by wire transfer of same day funds to the Company’s account for the number of shares for which the purchase rights hereunder are being exercised. The exercise of this Warrant shall be deemed to have been effected immediately prior to the close of business on the day on which this Warrant shall have been surrendered to the Company as provided herein or at such later date as may be specified in the executed form of subscription, and at such time, the person or persons in whose name or names any certificate or certificates for shares of stock shall be issuable upon such exercise, as provided herein, shall be deemed to have become the holder or holders of record thereof.
  1.4  
Net Exercise . At the election of the Holder and at any time during which this Warrant may be exercised pursuant to its terms, the Holder, in lieu of the payment in cash of the Exercise Price following delivery to the Corporation of a Notice of Exercise under Section 1.3 , may elect to undertake a Net Exercise of this Warrant to such extent as the Holder may determine. A “ Net Exercise ” shall mean that the Corporation, in lieu of receiving a cash payment of the Exercise Price for each Warrant Share, shall issue a number of Warrant Shares computed using the following formula:

 

 


 

             
 
          x = [y times (a-b)] divided by a
 
           
where
  x   =   the number of Warrant Shares to be issued to the Holder
 
  y   =   the number of Warrant Shares purchasable under this Warrant (at the date of such calculation)
 
  a   =   the Fair Market Value of one (1) Warrant Share (at the date of such calculation)
 
  b   =   the Exercise Price (as adjusted to the date of such calculation)
 
           
For example, if this Warrant were exercisable for fifty thousand (50,000) Warrant Shares, the Fair Market Value of one (1) Warrant Share were Four Dollars ($4.00) at the time of such Net Exercise, and the Exercise Price were One Dollar ($1.00), then the Corporation would issue that number of Warrant Shares calculated as follows:
 
           
 
  x   =   [50,000 times ($4.00 – $1.00)] divided by $4.00
 
           
 
  x   =   37,500 shares
2.  Adjustments to Exercise Price . The number and kind of shares of Stock issuable upon the exercise of this Warrant and the exercise price hereunder shall be subject to adjustment from time to time upon the happening of certain events, as follows:
2.1 Splits and Subdivisions . If the Company should at any time or from time to time fix a record date for the effectuation of a split or subdivision of the outstanding shares of Membership Interest or shares of stock received in exchange for such Membership Interests (the “Stock” for purposes hereof) or the determination of the holders of Stock entitled to receive a dividend or other distribution payable in additional shares of Stock or other securities or rights convertible into, or entitling the holder thereof to receive directly or indirectly, additional shares of Stock (hereinafter referred to as the “Stock Equivalents”) without payment of any consideration by such holder for the additional shares of Stock or Stock Equivalents, then, as of such record date (or the date of such distribution, split or subdivision if no record date is fixed), the Exercise Price shall be appropriately decreased and the number of shares of Stock which this Warrant are exercisable for, if any, shall be appropriately increased in proportion to such increase of outstanding shares.
2.2 Combination of Shares . If the number of shares of Stock outstanding at any time after the date hereof is decreased by a reverse stock split or other combination of the outstanding shares of Stock, the Exercise Price shall be appropriately increased and the number of shares of Stock which this Warrant are exercisable for shall be appropriately decreased in proportion to such decrease in outstanding shares.

 

 


 

2.3 Mergers, Consolidation or Sale of Assets . If at any time or from time to time there shall be a capital reorganization of the Stock (other than a subdivision, combination, reclassification or exchange of shares provided for elsewhere in this Section 2 ) or a merger or consolidation of the Company with or into another corporation, or the sale of all or substantially all of the Company’s assets to any other person or entity, then as a part of such reorganization, merger, consolidation or sale, provision shall be made, in form and substance reasonably acceptable to the Holder, so that the Holder shall thereafter be entitled to receive upon the exercise of this Warrant (or a Warrant in form and substance satisfactory to the Holder issued in replacement hereof), the number of shares of capital stock or other securities or property of the Company, or of the successor corporation resulting from such reorganization, merger, consolidation or sale, to which a holder of the number of shares of Stock (or any shares of stock or other securities which may be) issuable upon the exercise of this Warrant would have received if this Warrant had been exercised in full immediately prior to such reorganization, merger, consolidation or sale, all subject to further adjustment as provided herein. The provisions of this Section 2.3 shall similarly apply to successive reorganizations, consolidations, mergers and sales.
2.4 Adjustments for Other Distributions . In the event the Company shall declare a distribution payable in securities of other persons or entities, evidences of indebtedness issued by the Company or other persons, assets (excluding regular cash dividends) or options or rights not referred to in Section 2.1 with respect to the Stock, then, in each such case for the purpose of this Section 2.4 , upon exercise of this Warrant the Holder shall be entitled to a proportionate share of any such distribution as though such Holder was the holder of the number of shares of Stock of the Company into which this Warrant may be exercised as of the record date fixed for the determination of the holders of Stock of the Company entitled to receive such distribution, all subject to further adjustment as provided herein.
2.5 Reclassification or Reorganization . If the Stock (or any shares of stock or other securities) which may be issuable upon the exercise of this Warrant shall be changed into the same or different number of shares of any class or classes of capital stock, whether by capital reorganization, reclassification or otherwise (other than a subdivision or combination of shares or stock dividend provided for in Sections 2.1 , 2.2 and 2.4 above, or a reorganization, merger, consolidation or sale of assets provided for in Section 2.3 above), then and in each such event the Holder shall be entitled to receive upon the exercise of this Warrant the kind and amount of shares of capital stock and other securities and property receivable upon such reorganization, reclassification or other change, to which a holder of the number of shares of Stock (or any shares of stock or other securities which may be) issuable upon the exercise of this Warrant would have received if this Warrant had been exercised immediately prior to such reorganization, reclassification or other change, all subject to further adjustment as provided herein.
2.6 Notice of Adjustments and Record Dates . The Company shall promptly notify the Holder in writing of each adjustment or readjustment of the Exercise Price hereunder and the number of shares of Stock issuable upon the exercise of this Warrant. Such notice shall state the adjustment or readjustment and show in reasonable detail the facts on which that adjustment or readjustment is based.

 

 


 

2.7 No Impairment . The Company shall not avoid or seek to avoid the observance or performance of any of the terms to be observed or performed hereunder by the Company, but shall at all times in good faith assist in the carrying out of all the provisions of this Warrant. Without limiting the generality of the foregoing, the Company (a) shall at all times reserve and keep available a number of its authorized shares of Stock, free from all preemptive rights therein, which shall be sufficient to permit the exercise of this Warrant and (b) shall take all such action as may be necessary or appropriate in order that all shares of Stock as may be issued pursuant to the exercise of this Warrant shall, upon issuance, be duly and validly issued, fully paid and nonassessable and free from all taxes, liens and charges with respect to the issue thereof.
2.8 Priorities Preserved. This provisions of this Section 2 shall not apply to adjustments made to preserve the economic value of preferences held by the holders of Class A or Class B Membership Interests in Lifeline in connection with any share exchange, merger or consolidation of Lifeline as described in Section 1 hereof.
3.  Replacement of the Warrant . On receipt by the Company of evidence reasonably satisfactory to the Company of the loss, theft, destruction or mutilation of this Warrant and, in the case of any such loss, theft or destruction of this Warrant, on delivery of an indemnity agreement reasonably satisfactory in form to the Company or, in the case of any such mutilation, on surrender and cancellation of the Warrant, the Company at its expense shall execute and deliver to the Holder, in lieu thereof, a new Warrant of like tenor.
4.  No Rights or Liability as a Stockholder . This Warrant does not entitle the Holder hereof to any voting rights or other rights as a stockholder of the Company. No provisions hereof, in the absence of affirmative action by the Holder to purchase Stock, and no enumeration herein of the rights or privileges of the Holder, shall give rise to any liability of the Holder as a stockholder of the Company.
5. Miscellaneous .
5.1 Compliance with Securities Laws . The Holder of this Warrant, by acceptance hereof, acknowledges that (i) it is an “accredited investor” as that term is defined in Rule 501(a) of Regulation D under the Securities Act of 1933, as amended (the “Securities Act”); (ii) it has knowledge and experience in financial and business matters such that it is capable of evaluating the merits and risks of acquiring this Warrant; (iii) it is acquiring this Warrant and the shares of Stock to be issued upon exercise hereof solely for its own account, not as a nominee or agent, and not with a view to, or for resale in connection with, any distribution thereof, and that it will not offer, sell or otherwise dispose of this Warrant or any shares of Stock to be issued upon exercise hereof or conversion thereof except under circumstances that will not result in a violation of the Securities Act or any applicable state securities laws; (iv) it understands that no public market now exists for this Warrant, or for the shares of Stock to be issued upon exercise thereof, and that the Company has made no assurances that a public market will ever exist for this Warrant or any shares so issued; (v) it has had an opportunity to discuss the tax consequences of its acquisition of this Warrant with its own tax advisor, that it is relying solely on such advisors and not on any statements or representations of the Company or any of the Company’s agents with respect to such tax consequences, and that it understands that it, and not the Company, shall be responsible for its own tax liability that may arise as a result of its acquisition of this Warrant; and (vi) the Holder either has a preexisting personal or business relationship with the Company, its officers or its directors or, by reason of its business or financial experience, or the business or financial experience of its professional advisors (being unaffiliated with and not compensated by the Company or any affiliate or selling agent of the Company) can reasonably be assumed to have the capacity to protect its interests in connection with its acquisition of the Warrant.

 

 


 

5.2 Transfer of Warrant . This Warrant and the shares of Stock issued upon the exercise of this Warrant (the “Securities”) shall be transferable or assignable by the Holder so long as such transfer is made in compliance with applicable securities laws and as set forth below. Prior to any proposed sale, assignment, transfer or pledge of any Securities, unless there is in effect a registration statement under the Securities Act covering the proposed transfer, the Holder shall give written notice to the Company of the Holder’s intention to effect such transfer, sale, assignment or pledge. Each such notice shall describe the manner and circumstances of the proposed transfer, sale, assignment or pledge in sufficient detail, and, if requested by the Company, the Holder shall also provide, at the Holder’s expense, either (i) a written opinion addressed to the Company of legal counsel who shall be, and whose legal opinion shall be, reasonably satisfactory to the Company, to the effect that the proposed transfer of the Securities may be effected without registration under the Securities Act, or (ii) a “no action” letter from the Securities and Exchange Commission (the “Commission”) to the effect that the transfer of such securities without registration will not result in a recommendation by the staff of the Commission that action be taken with respect thereto, whereupon the Holder shall be entitled to transfer such Securities in accordance with the terms of the notice delivered by the holder to the Company; provided, however, that the Company shall not request an opinion of counsel or “no action” letter with respect to (i) a transfer not involving a change in beneficial ownership, (ii) a transaction involving the distribution without consideration of the Securities by the holder to its constituent partners, members or beneficiaries in proportion to their ownership interests in the holder, or to the Settlor of a revocable trust (iii) a transaction involving the transfer without consideration of the Securities by an individual holder during such holder’s lifetime by way of gift or on death by will or intestacy or (iv) a transfer to an affiliate (as defined in Rule 405 of the Securities Act) of the Holder.
5.3 Lock-up. Provided that all holders of at least 1% of the outstanding securities of the Company and all officers and directors of the Company are also so bound, the Holder shall not, to the extent requested by any managing underwriter of the Company, sell or otherwise transfer or dispose of (other than to donees who agree to be similarly bound) any shares of Stock issued upon the exercise of this Warrant during a period (the “Stand-Off Period”) equal to (i) 180 days following the effective date of a registration statement for an initial public offering of the Company’s Stock for sale to the public and (ii) 120 days following the effective date of a registration statement of any secondary offering of the Company under the Securities Act (or in each case such shorter period as the Company or managing underwriter may authorize), and except in each case, for securities sold as part of any offerings covered by any registration statements in accordance with the provisions of the Registration Agreement. In order to enforce the foregoing covenant, the Company may impose stock transfer restrictions with respect to the shares of Stock issued upon the exercise of this Warrant until the end of the Stand-Off Period. Notwithstanding the foregoing, the obligations described in this Section 5.3 shall not apply to a registration relating solely to employee benefit plans on Form S-1 or Form S-8 or similar forms which may be promulgated in the future, or a registration relating solely to a Commission Rule 145 transaction on Form S-4 or similar forms which may be promulgated in the future.

 

 


 

5.4 Restrictive Legends. The certificates representing the Stock and any securities of the Company issued with respect thereto shall be imprinted with legends restricting transfer except in compliance with the terms hereof and with applicable Federal and state securities laws.
5.5 “Piggy Back” Registration. If at any time the Company shall determine to register under the Securities Act any of its Stock (other than a registration relating solely to the sale of securities on a form which does not include substantially the same information as would be required to be included in a registration statement covering the sale of the Holder’s Shares), it shall send to each Holder written notice of such determination and, if within twenty (20) days after receipt of such notice, such Holder shall so request in writing, the Company shall use its best efforts to include in such registration statement all or any part of the Holder’s Shares that such Holder requests to be registered. Notwithstanding the foregoing, if the managing underwriter shall impose a limitation on the number of shares of Stock included in any such registration statement because, in such underwriter’s judgment, such limitation is necessary based on market conditions, the Company may exclude, to the extent so advised by the underwriters, the Holder’s Shares from the underwriting; provided, however, that if the underwriters do not entirely exclude all shares issuable upon exercise of any other outstanding warrants to purchase Stock (the “Registrable Shares”) from such Initial Public Offering, the Company shall be obligated to include in such registration statement, with respect to the requesting Holder, an amount of Registrable Shares equal to the product of (i) the number of Registrable Shares that remain available for registration after the underwriter’s cut back and (ii) such Holder’s percentage ownership of all such securities.
5.6 Titles and Subtitles . The titles and subtitles used in this Warrant are for convenience only and are not to be considered in construing or interpreting this Warrant.
5.7 Notices . Except as otherwise provided herein, all notices under this warrant shall be in writing and shall be delivered by personal service, facsimile, courier service promising overnight delivery or certified mail (if such service is not available, then by first class mail), postage prepaid. Notices shall be addressed as follows:
If to the Company:
C/O Mr. William B. Adams
711 Linda Flora Drive
Los Angeles, CA 90049
 
Phone 310-472-3017
Fax 310-496-2850

 

 


 

         
If to the Holder:
       
 
       
 
       
 
       
 
       
 
       
With respect to any other Holder, such address as if provided by such Holder to the Company. Any party may change its address for the purpose of this Section 5.7 by giving the other party written notice of its new address in the manner set forth above.
5.8 Attorneys’ Fees . If any action at law or in equity is necessary to enforce or interpret the terms of this Warrant, the prevailing party shall be entitled to reasonable attorneys’ fees, costs and disbursements in addition to any other relief to which such party may be entitled.
5.9 Amendments and Waivers . Any term of this Warrant may be amended and the observance of any term of this Warrant may be waived (either generally or in a particular instance and either retroactively or prospectively), with the written consent of the Company and the Holder. Any amendment or waiver affected in accordance with this Section 5.9 shall be binding upon the Holder of this Warrant (and of any securities into which this Warrant are convertible), each future holder of all such securities, and the Company.
5.10 Severability . If one or more provisions of this Warrant are held to be unenforceable under applicable law, such provision shall be excluded from this Warrant and the balance of the Warrant shall be interpreted as if such provision were so excluded and shall be enforceable in accordance with its terms.
5.11 Governing Law . This Warrant shall be governed by and construed and enforced in accordance with the laws of the State of California, without giving effect to its conflicts of laws principles.
Signature page follows
             
    Lifeline Cell Technology, LLC  
 
           
         
       
 
  By:   William B. Adams  
 
  Its:   Managing Member  

 

 


 

SCHEDULE A
FORM OF SUBSCRIPTION
(To be signed only on exercise of Warrant)
To:  
Lifeline Cell Technology, LLC.
The undersigned, the holder of the Warrant attached hereto, hereby elects to exercise the purchase rights represented by such Warrant for, and to purchase thereunder, ___shares of Stock of Lifeline Cell Technology, LLC., or shares of any corporation for which such shares of Lifeline may be exchanged.
The undersigned elects one of the following:
  1.  
The undersigned has included herewith payment of $___representing the purchase price of such shares in full. OR
 
  2.  
The undersigned elects a “cashless exercise” as described in the warrant.
The undersigned elects 1.___or 2. ___, please initial.
Please issue a certificate for such shares be issued in the name of ___, and delivered to ___, whose address is ___ whose social security number/taxpayer identification number is ___.
The undersigned represents that the aforesaid shares are being acquired for the account of the undersigned for investment and not with a view to, or for resale in connection with, the distribution thereof and that the undersigned has no present intention of distributing or reselling such shares.
(Signature must conform in all respects to name of the Holder as specified on the face of the Warrant)
             
Dated:
           
 
           
 
          (Print Name)
 
           
 
           
 
           
 
           
 
      Address:    
 
           
 
           
 
           

 

 

 

Exhibit 4.3
NEITHER THE WARRANTS REPRESENTED BY THIS CERTIFICATE NOR THE SHARES ISSUABLE UPON EXERCISE HEREOF HAVE BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED. NEITHER THE WARRANTS NOR SUCH SHARES MAY BE OFFERED OR SOLD EXCEPT PURSUANT TO AN EFFECTIVE REGISTRATION STATEMENT UNDER SUCH ACT, OR AN EXEMPTION FROM REGISTRATION UNDER SUCH ACT.
WARRANT FOR THE PURCHASE OF SHARES OF COMMON STOCK
     
No. 1   ___Shares
THIS CERTIFIES that, for value received, ___(the “Holder”), is entitled to subscribe for and purchase from ___, a ___corporation (the “Company”), upon the terms and conditions set forth herein, at any time or from time to time after the date hereof, and before 5:00 p.m. on ___ ___, 2011, Pacific Standard time (the “Exercise Period”), ___(___) shares of common stock, par value $.001 per share, of the Company (“Common Stock”), at an exercise price of $1.00 per share (the “Exercise Price”). This Warrant is being issued in connection with the Holder acting as placement agent in connection with the sale of up to 12,000,000 shares of Common Stock pursuant to a Confidential Private Placement Memorandum dated August 3, 2006, of International Stem Cell Corporation. As used herein, the term “this Warrant” shall mean and include this Warrant and any Warrant or Warrants hereafter issued as a consequence of the exercise or transfer of this Warrant in whole or in part.
The number of shares of Common Stock issuable upon exercise of the Warrants (the “Warrant Shares”) and the Exercise Price may be adjusted from time to time as hereinafter set forth.
1. This Warrant may be exercised during the Exercise Period, as to the whole or any lesser number of the respective whole Warrant Shares, as follows:
(a) by the surrender of this Warrant (with the form of election at the end hereof duly executed) to the Company at its office as set forth in the form of election attached hereto, or at such other place as is designated in writing by the Company, together with a certified or bank cashier’s check payable to the order of the Company in an amount equal to the Exercise Price multiplied by the number of respective Warrant Shares for which this Warrant is being exercised; or
(b) by surrender of this Warrant (with the notice of cashless exercise at the end hereof duly executed) to the Company at its office as set forth in the notice of cashless exercise attached hereto, or at such other place as is designated in writing by the Company, in which event the Company shall issue to the Holder the number of Warrant Shares determined as follows:
X = Y (A-B)/A

 

 


 

where:
X = the number of Warrant Shares to be issued to the Holder.
Y = the number of Warrant Shares with respect to which this Warrant is being exercised.
A = the closing sale price of the Common Stock for the trading day immediately prior to the date of exercise.
B = the Exercise Price.
2. Upon each exercise of the Holder’s rights to purchase Warrant Shares, either pursuant to Section 1(a) or (b) above, the Holder shall be deemed to be the holder of record of the Warrant Shares issuable upon such exercise, notwithstanding that the transfer books of the Company shall then be closed or certificates representing such Warrant Shares shall not then have been actually delivered to the Holder. For purposes of Rule 144 promulgated under the Securities Act of 1933, as amended (the “Act”), it is intended, understood and acknowledged that the Warrant Shares issued in a cashless exercise transaction pursuant to Section 1(b) above shall be deemed to have been acquired by the Holder, and the holding period for the Warrant Shares shall be deemed to have been commenced, on the issue date of the Warrant. As soon as practicable after each such exercise of this Warrant and payment of the Exercise Price, the Company shall issue and deliver to the Holder a certificate or certificates for the Warrant Shares issuable upon such exercise, registered in the name of the Holder or its designee. If this Warrant should be exercised in part only, the Company shall, upon surrender of this Warrant for cancellation, execute and deliver a new Warrant evidencing the right of the Holder to purchase the balance of the Warrant Shares (or portions thereof) subject to purchase hereunder.
3. Any Warrants issued upon the transfer or exercise in part of this Warrant shall be numbered and shall be registered in a Warrant Register as they are issued. The Company shall be entitled to treat the registered holder of any Warrant on the Warrant Register as the owner in fact thereof for all purposes and shall not be bound to recognize any equitable or other claim to or interest in such Warrant on the part of any other person, and shall not be liable for any registration or transfer of Warrants which are registered or to be registered in the name of a fiduciary or the nominee of a fiduciary unless made with the actual knowledge that a fiduciary or nominee is committing a breach of trust in requesting such registration or transfer, or with the knowledge of such facts that its participation therein amounts to bad faith. This Warrant shall be transferable only on the books of the Company upon delivery thereof duly endorsed by the Holder or by his duly authorized attorney or representative, or accompanied by proper evidence of succession, assignment, or authority to transfer. In all cases or transfer by an attorney, executor, administrator, guardian, or other legal representative, duly authenticated evidence of his or its authority shall be produced. Upon any registration of transfer, the Company shall deliver a new Warrant or Warrants to the person entitled thereto. This Warrant may be exchanged, at the option of the Holder thereof, for another Warrant, or other Warrants of different denominations, of like tenor and representing in the aggregate the right to purchase a like number of Warrant Shares (or portions thereof), upon surrender to the Company or its duly authorized agent. Notwithstanding the foregoing, the Company shall have no obligation to cause Warrants to be transferred on its books to any person if, in the opinion of counsel to the Company, such transfer does not comply with the provisions of the Act and the rules and regulations thereunder.

 

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4. The Company shall at all times reserve and keep available out of its authorized and unissued Common Stock, solely for the purpose of providing for the exercise of the rights to purchase all Warrant Shares granted pursuant to the Warrants, such number of shares of Common Stock as shall, from time to time, be sufficient therefor. The Company covenants that all shares of Common Stock issuable upon exercise of this Warrant, upon receipt by the Company of the full Exercise Price therefor if such exercise is pursuant to Section 1(a) above, or upon receipt by the Company of the notice of cashless exercise duly executed if such exercise is pursuant to Section 1(b) above, shall be validly issued, fully paid, non-assessable, and free of preemptive rights.
5. (a) In case the Company shall at any time after the date the Warrants were first issued (i) declare a dividend on the outstanding Common Stock payable in shares of its capital stock, (ii) subdivide the outstanding Common Stock, (iii) combine the outstanding Common Stock into a smaller number of shares, or (iv) issue any shares of its capital stock by reclassification of the Common Stock (including any such reclassification in connection with a consolidation or merger in which the Company is the continuing corporation), then, in each case, the Exercise Price, and the number of Warrant Shares issuable upon exercise of this Warrant, in effect at the time of the record date for such dividend or of the effective date of such subdivision, combination, or reclassification, shall be proportionately adjusted so that the Holder after such time shall be entitled to receive the aggregate number and kind of shares which, if such Warrant had been exercised immediately prior to such time, he would have owned upon such exercise and been entitled to receive by virtue of such dividend, subdivision, combination, or reclassification. Such adjustment shall be made successively whenever any event listed above shall occur.
(b) In case the Company shall issue or fix a record date for the issuance to all holders of Common Stock of rights, options, or warrants to subscribe for or purchase Common Stock (or securities convertible into or exchangeable for Common Stock) at a price per share (or having a conversion or exchange price per share, if a security convertible into or exchangeable for Common Stock) less than the Exercise Price per share of Common Stock on such record date, then, in each case, the Exercise Price shall be adjusted by multiplying the Exercise Price in effect immediately prior to such record date by a fraction, the numerator of which shall be the number of shares of Common Stock outstanding on such record date plus the number of shares of Common Stock which the aggregate offering price of the total number of shares of Common Stock so to be offered (or the aggregate initial conversion or exchange price of the convertible or exchangeable securities so to be offered) would purchase at such current Exercise Price and the denominator of which shall be the number of shares of Common Stock outstanding on such record date plus the number of additional shares of Common Stock to be offered for subscription or purchase (or into which the convertible or exchangeable securities so to be offered are initially

 

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convertible or exchangeable). Such adjustment shall become effective at the close of business on such record date; provided , however , that, to the extent the shares of Common Stock (or securities convertible into or exchangeable for shares of Common Stock) are not delivered, the Exercise Price shall be readjusted after the expiration of such rights, options, or warrants (but only with respect to Warrants exercised after such expiration), to the Exercise Price which would then be in effect had the adjustments made upon the issuance of such rights, options, or warrants been made upon the basis of delivery of only the number of shares of Common Stock (or securities convertible into or exchangeable for shares of Common Stock) actually issued. In case any subscription price may be paid in a consideration part or all of which shall be in a form other than cash, the value of such consideration shall be as determined in good faith by the board of directors of the Company, whose determination shall be conclusive absent manifest error. Shares of Common Stock owned by or held for the account of the Company or any majority-owned subsidiary shall not be deemed outstanding for the purpose of any such computation.
(c) In case the Company shall distribute to all holders of Common Stock (including any such distribution made to the stockholders of the Company in connection with a consolidation or merger in which the Company is the continuing corporation) evidences of its indebtedness or assets (other than cash dividends or distributions and dividends payable in shares of Common Stock), or rights, options, or warrants to subscribe for or purchase Common Stock, or securities convertible into or exchangeable for shares of Common Stock (excluding those with respect to the issuance of which an adjustment of the Exercise Price is provided pursuant to Section 5(b) hereof), then, in each case, the Exercise Price shall be adjusted by multiplying the Exercise Price in effect immediately prior to the record date for the determination of stockholders entitled to receive such distribution by a fraction, the numerator of which shall be the Exercise Price per share of Common Stock on such record date, less the fair market value (as determined in good faith by the board of directors of the Company, whose determination shall be conclusive absent manifest error) of the portion of the evidences of indebtedness or assets so to be distributed, or of such rights, options, or warrants or convertible or exchangeable securities, applicable to one share, and the denominator of which shall be such current Exercise Price per share of Common Stock. Such adjustment shall be made whenever any such distribution is made, and shall become effective on the record date for the determination of shareholders entitled to receive such distribution.
(d) In case the Company shall issue shares of Common Stock or rights, options, or warrants to subscribe for or purchase Common Stock, or securities convertible into or exchangeable for Common Stock (excluding shares, rights, options, warrants, or convertible or exchangeable securities issued or issuable (i) in any of the transactions with respect to which an adjustment of the Exercise Price is provided pursuant to Sections 5(a), 5(b) or 5(c) above or (ii) upon exercise of the Warrant), at a price per share (determined, in the case of such rights, options, warrants, or convertible or exchangeable securities, by dividing (x) the total amount received or receivable by the Company in consideration of the sale and issuance of such rights, options, warrants, or convertible or exchangeable securities, plus the minimum aggregate consideration payable to the Company upon exercise, conversion, or exchange thereof, by (y) the maximum number of shares covered by such rights, options, warrants, or convertible or

 

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exchangeable securities) lower than the Exercise Price per share of Common Stock in effect immediately prior to such issuance, then the Exercise Price shall be reduced on the date of such issuance to a price (calculated to the nearest cent) determined by multiplying the Exercise Price in effect immediately prior to such issuance by a fraction, (iii) the numerator of which shall be an amount equal to the sum of (A) the number of shares of Common Stock outstanding immediately prior to such issuance plus (B) the quotient obtained by dividing the consideration received by the Company upon such issuance by such current Exercise Price, and (iv) the denominator of which shall be the total number of shares of Common Stock outstanding immediately after such issuance. For the purposes of such adjustments, the maximum number of shares which the holders of any such rights, options, warrants, or convertible or exchangeable securities shall be entitled to initially subscribe for or purchase or convert or exchange such securities into shall be deemed to be issued and outstanding as of the date of such issuance, and the consideration received by the Company therefor shall be deemed to be the consideration received by the Company for such rights, options, warrants, or convertible or exchangeable securities, plus the minimum aggregate consideration or premiums stated in such rights, options, warrants, or convertible or exchangeable securities to be paid for the shares covered thereby. No further adjustment of the Exercise Price shall be made as a result of the actual issuance of shares of Common Stock on exercise of such rights, options, or warrants or on conversion or exchange of such convertible or exchangeable securities. On the expiration or the termination of such rights, options, or warrants, or the termination of such right to convert or exchange, the Exercise Price shall be readjusted (but only with respect to Warrants exercised after such expiration or termination) to such Exercise Price as would have obtained had the adjustments made upon the issuance of such rights, options, warrants, or convertible or exchangeable securities been made upon the basis of the delivery of only the number of shares of Common Stock actually delivered upon the exercise of such rights, options, or warrants or upon the conversion or exchange of any such securities; and on any change of the number of shares of Common Stock deliverable upon the exercise of any such rights, options, or warrants or conversion or exchange of such convertible or exchangeable securities or any change in the consideration to be received by the Company upon such exercise, conversion, or exchange, including, but not limited to, a change resulting from the anti-dilution provisions thereof, the Exercise Price, as then in effect, shall forthwith be readjusted (but only with respect to Warrants exercised after such change) to such Exercise Price as would have been obtained had an adjustment been made upon the issuance of such rights, options, or warrants not exercised prior to such change, or securities not converted or exchanged prior to such change, on the basis of such change. In case the Company shall issue shares of Common Stock or any such rights, options, warrants, or convertible or exchangeable securities for a consideration consisting, in whole or in part, of property other than cash or its equivalent, then the “price per share” and the “consideration received by the Company” for purposes of the first sentence of this Section 5(d) shall be as determined in good faith by the board of directors of the Company, whose determination shall be conclusive absent manifest error. Shares of Common Stock owned by or held for the account of the Company or any majority-owned subsidiary shall not be deemed outstanding for the purpose of any such computation.

 

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(e) No adjustment in the Exercise Price shall be required if such adjustment is less than $.05; provided , however , that any adjustments which by reason of this Section 5 are not required to be made shall be carried forward and taken into account in any subsequent adjustment. All calculations under this Section 5 shall be made to the nearest cent or to the nearest one-thousandth of a share, as the case may be.
(f) In any case in which this Section 5 shall require that an adjustment in the Exercise Price be made effective as of a record date for a specified event, the Company may elect to defer, until the occurrence of such event, issuing to the Holder, if the Holder exercised this Warrant after such record date, the shares of Common Stock, if any, issuable upon such exercise over and above the shares of Common Stock, if any, issuable upon such exercise on the basis of the Exercise Price in effect prior to such adjustment; provided , however , that the Company shall deliver to the Holder a due bill or other appropriate instrument evidencing the Holder’s right to receive such additional shares upon the occurrence of the event requiring such adjustment.
(g) Upon each adjustment of the Exercise Price as a result of the calculations made in Sections 5(b), 5(c) or 5(d) hereof, this Warrant shall thereafter evidence the right to purchase, at the adjusted Exercise Price, that number of shares (calculated to the nearest thousandth) obtained by dividing (A) the product obtained by multiplying the number of shares purchasable upon exercise of this Warrant prior to adjustment of the number of shares by the Exercise Price in effect prior to adjustment of the Exercise Price by (B) the Exercise Price in effect after such adjustment of the Exercise Price.
(h) Whenever there shall be an adjustment as provided in this Section 5, the Company shall promptly cause written notice thereof to be sent by registered mail, postage prepaid, to the Holder, at its address as it shall appear in the Warrant Register, which notice shall be accompanied by an officer’s certificate setting forth the number of Warrant Shares purchasable upon the exercise of this Warrant and the Exercise Price after such adjustment and setting forth a brief statement of the facts requiring such adjustment and the computation thereof, which officer’s certificate shall be conclusive evidence of the correctness of any such adjustment absent manifest error.
6. (a) In case of any consolidation with or merger of the Company with or into another corporation (other than a merger or consolidation in which the Company is the surviving or continuing corporation), or in case of any sale, lease, or conveyance to another corporation of the property and assets of any nature of the Company as an entirety or substantially as an entirety, such successor, leasing, or purchasing corporation, as the case may be, shall (i) execute with the Holder an agreement providing that the Holder shall have the right thereafter to receive upon exercise of this Warrant solely the kind and amount of shares of stock and other securities, property, cash, or any combination thereof receivable upon such consolidation, merger, sale, lease, or conveyance by a holder of the number of shares of Common Stock for which this Warrant; might have been exercised immediately prior to such consolidation, merger, sale, lease, or conveyance and (ii) make effective provision in its certificate of incorporation or otherwise, if necessary, to effect such agreement. Such agreement shall provide for adjustments which shall be as nearly equivalent as practicable to the adjustments in Section 5.

 

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(b) In case of any reclassification or change of the shares of Common Stock issuable upon exercise of this Warrant (other than a change in par value or from no par value to a specified par value, or as a result of a subdivision or combination, but including any change in the shares into two or more classes or series of shares), or in case of any consolidation or merger of another corporation into the Company in which the Company is the continuing corporation and in which there is a reclassification or change (including a change to the right to receive cash or other property) of the shares of Common Stock (other than a change in par value, or from no par value to a specified par value, or as a result of a subdivision or combination, but including any change in the shares into two or more classes or series of shares), the Holder shall have the right thereafter to receive upon exercise of this Warrant solely the kind and amount of shares of stock and other securities, property, cash, or any combination thereof receivable upon such reclassification, change, consolidation, or merger by a holder of the number of shares of Common Stock for which this Warrant might have been exercised immediately prior to such reclassification, change, consolidation, or merger. Thereafter, appropriate provision shall be made for adjustments which shall be as nearly equivalent as practicable to the adjustments in Section 5.
(c) The above provisions of this Section 6 shall similarly apply to successive reclassifications and changes of shares of Common Stock and to successive consolidations, mergers, sales, leases or conveyances.
7. In case at any time the Company shall propose:
(a) to pay any dividend or make any distribution on shares of Common Stock in shares of Common Stock or make any other distribution (other than regularly scheduled cash dividends which are not in a greater amount per share than the most recent such cash dividend) to all holders of Common Stock; or
(b) to issue any rights, warrants, or other securities to all holders of Common Stock entitling them to purchase any additional shares of Common Stock or any other rights, warrants, or other securities; or
(c) to effect any reclassification or change of outstanding shares of Common Stock, or any consolidation, merger, sale, lease, or conveyance of property, described in Section 6; or
(d) to effect any liquidation, dissolution, or winding-up of the Company; or
(e) to take any other action which would cause an adjustment to the Exercise Price;

 

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then, and in any one or more of such cases, the Company shall give written notice thereof, by registered mail, postage prepaid, to the Holder at the Holder’s address as it shall appear in the Warrant Register, mailed at least 15 days prior to (i) the date as of which the holders of record of shares of Common Stock to be entitled to receive any such dividend, distribution, rights, warrants, or other securities are to be determined, (ii) the date on which any such reclassification, change of outstanding shares of Common Stock, consolidation, merger, sale, lease, conveyance of property, liquidation, dissolution, or winding-up is expected to become effective, and the date as of which it is expected that holders of record of shares of Common Stock shall be entitled to exchange their shares for securities or other property, if any, deliverable upon such reclassification, change of outstanding shares, consolidation, merger, sale, lease, conveyance of property, liquidation, dissolution, or winding-up, or (iii) the date of such action which would require an adjustment to the Exercise Price.
8. (a) If at any time prior to the expiration of the Exercise Period, the Company shall file a registration statement (other than a registration statement on Form S-4, Form S-8 or any successor form) with the U.S. Securities and Exchange Commission (the “Commission”) while any Registrable Securities (as hereinafter defined) are outstanding, the Company shall give all the then holders of any Registrable Securities (the “Eligible Holders”) at least 30 days prior written notice of the filing of such registration statement. If requested by any Eligible Holder in writing within 20 days after receipt of any such notice, the Company shall, at the Company’s sole expense (other than the fees and disbursements of counsel for the Eligible Holders and the underwriting discounts, if any, payable in respect of the Registrable Securities sold by any Eligible Holder), register or qualify all or, at each Eligible Holder’s option, any portion of the Registrable Securities of any Eligible Holders who shall have made such request, concurrently with the registration of such other securities, all to the extent requisite to permit the public offering and sale of the Registrable Securities through the facilities of all appropriate securities exchanges and the over-the-counter market, and will use its best efforts through its officers, directors, auditors, and counsel to cause such registration statement to become effective as promptly as practicable. Notwithstanding the foregoing, if the managing underwriter of any such offering shall advise the Company in writing that, in its opinion, the distribution of all or a portion of the Registrable Securities requested to be included in the registration concurrently with the securities being registered by the Company would materially adversely affect the distribution of such securities by the Company for its own account, then any Eligible Holder who shall have requested registration of his or its Registrable Securities shall delay the offering and sale of such Registrable Securities (or the portions thereof so designated by such managing underwriter) for such period, not to exceed 90 days (the “Delay Period”), as the managing underwriter shall request, provided that no such delay shall be required as to any Registrable Securities if any securities of the Company are included in such registration statement and eligible for sale during the Delay Period for the account of any person other than the Company and any Eligible Holder unless the securities included in such registration statement and eligible for sale during the Delay Period for such other person shall have been reduced pro rata to the reduction of the Registrable Securities which were requested to be included and eligible for sale during the Delay Period in such registration. As used herein, “Registrable Securities” shall mean the Warrants and the Warrant Shares which, in each case, have not been previously sold pursuant to a registration statement or Rule 144 promulgated under the Act.

 

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(b) If, at any time prior to the expiration of the Exercise Period, the Company shall receive a written request, from Eligible Holders who in the aggregate own (or upon exercise of all Warrants then outstanding or issuable would own) 50% of the total number of shares of Common Stock then included (or upon such exercises would be included) in the Registrable Securities (the “Majority Holders”), to register the sale of all or part of such Registrable Securities, the Company shall, as promptly as practicable, prepare and file with the Commission a registration statement sufficient to permit the public offering and sale of the Registrable Securities through the facilities of all appropriate securities exchanges and the over-the-counter market, and will use its best efforts through its officers, directors, auditors, and counsel to cause such registration statement to become effective as promptly as practicable; provided , however , that the Company shall only be obligated to file one such registration statement for which all expenses incurred in connection with such registration (other than the fees and disbursements of counsel for the Eligible Holders and underwriting discounts, if any, payable in respect of the Registrable Securities sold by the Eligible Holders) shall be borne by the Company. The Company shall not be obligated to effect any registration of its securities pursuant to this Section 8(b) within six months after the effective date of a previous registration statement prepared and filed in accordance with Sections 8(a) or 8(b). Within three business days after receiving any request contemplated by this Section 8(b), the Company shall give written notice to all the other Eligible Holders, advising each of them that the Company is proceeding with such registration and offering to include therein all or any portion of any such other Eligible Holder’s Registrable Securities, provided that the Company receives a written request to do so from such Eligible Holder within 30 days after receipt by him or it of the Company’s notice.
(c) In the event of a registration pursuant to the provisions of this Section 8, the Company shall use its best efforts to cause the Registrable Securities so registered to be registered or qualified for sale under the securities or blue sky laws of such jurisdictions as the Eligible Holder or such holders may reasonably request; provided , however , that the Company shall not be required to qualify to do business in any state by reason of this Section 8(c) in which it is not otherwise required to qualify to do business.
(d) The Company shall keep effective any registration or qualification contemplated by this Section 8 and shall from time to time amend or supplement each applicable registration statement, preliminary prospectus, final prospectus, application, document, and communication for such period of time as shall be required to permit the Eligible Holders to complete the offer and sale of the Registrable Securities covered thereby. The Company shall in no event be required to keep any such registration or qualification in effect for a period in excess of nine months from the date on which the Eligible Holders are first free to sell such Registrable Securities; provided , however , that, if the Company is required to keep any such registration or qualification in effect with respect to securities other than the Registrable Securities beyond such period, the Company shall keep such registration or qualification in effect as it relates to the Registrable Securities for so long as such registration or qualification remains or is required to remain in effect in respect of such other securities.

 

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(e) In the event of a registration pursuant to the provisions of this Section 8, the Company shall furnish to each Eligible Holder such number of copies of the registration statement and of each amendment and supplement thereto (in each case, including all exhibits), such reasonable number of copies of each prospectus contained in such registration statement and each supplement or amendment thereto (including each preliminary prospectus), all of which shall conform to the requirements of the Act and the rules and regulations thereunder, and such other documents, as any Eligible Holder may reasonably request to facilitate the disposition of the Registrable Securities included in such registration.
(f) In the event of a registration pursuant to the provisions of this Section 8, the Company shall furnish each Eligible Holder of any Registrable Securities so registered with an opinion of its counsel (reasonably acceptable to the Eligible Holders) to the effect that (i) the registration statement has become effective under the Act and no order suspending the effectiveness of the registration statement, preventing or suspending the use of the registration statement, any preliminary prospectus, any final prospectus, or any amendment or supplement thereto has been issued, nor has the Commission or any securities or blue sky authority of any jurisdiction instituted or threatened to institute any proceedings with respect to such an order, (ii) the registration statement and each prospectus forming a part thereof (including each preliminary prospectus), and any amendment or supplement thereto, complies as to form with the Act and the rules and regulations thereunder, and (iii) such counsel has no knowledge of any material misstatement or omission in such registration statement or any prospectus, as amended or supplemented. Such opinion shall also state the jurisdictions in which the Registrable Securities have been registered or qualified for sale pursuant to the provisions of Section 8(c).
(g) In the event of a registration pursuant to the provision of this Section 8, the Company shall enter into a cross-indemnity agreement and a contribution agreement, each in customary form, with each underwriter, if any, and, if requested, enter into an underwriting agreement containing conventional representations, warranties, allocation of expenses, and customary closing conditions, including, but not limited to, opinions of counsel and accountants’ cold comfort letters, with any underwriter who acquires any Registrable Securities.
(h) In the event of a registration pursuant to the provisions of this Section 8:
(i) each Eligible Holder shall furnish to the Company in writing such appropriate information (relating to such Eligible Holder and the intention of such Eligible Holder as to proposed methods of sale or other disposition of their shares of Common Stock) and the identity of and compensation to be paid to any proposed underwriters to be employed in connection therewith as the Company, any underwriter, or the Commission or any other regulatory authority may request;
(ii) the Eligible Holders shall enter into the usual and customary form of underwriting agreement agreed to by the Company and any underwriter with respect to any such offering, if required, and such underwriting agreement shall contain the customary rights of indemnity between the Company, the underwriters, and such Eligible Holders;

 

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(iii) each Eligible Holder shall agree that he shall execute, deliver and/or file with or supply the Company, any underwriters, the Commission and/or any state or other regulatory authority such information, documents, representations, undertakings and/or agreements necessary to carry out the provisions of the registration covenants contained in this Section 8 and/or to effect the registration or qualification of his or its Registrable Securities under the Act and/or any of the laws and regulations of any state of governmental instrumentality;
(iv) the Company’s obligation to include any Registrable Securities in a registration statement shall be subject to the written agreement of each holder thereof to offer such securities in the same manner and on the same terms and conditions as the other securities of the same class are being offered pursuant to the registration statement, if such shares are being underwritten;
(v) in the event that all the Registrable Securities have not been sold on or prior to the expiration of the period specified in Section 8(d) above, the Company may de-register by post-effective amendment any Registrable Securities covered by the registration statement, but not sold on or prior to such date. The Company agrees that it will notify each holder of Registrable Securities of the filing and effective date of such post-effective amendment; and
(vi) each Eligible Holder agrees that upon notification by the Company that the prospectus in respect to any public offering covered by the provisions hereof is in need of revision, such Eligible Holder shall immediately upon receipt of such notification (x) cease to offer or sell any securities of the Company which must be accompanied by such prospectus, (y) return all such prospectuses in such Eligible Holder’s hands to the Company, and (z) not offer or sell any securities of the Company until such Holder has been provided with a current prospectus and the Company has given such Eligible Holder notification permitting such Eligible Holder to resume offers and sales.
(i) The Company agrees that until all the Registrable Securities have been sold under a registration statement or pursuant to Rule 144 under the Act, it shall keep current in filing all reports, statements and other materials required to be filed with the Commission to permit holders of the Registrable Securities to sell such securities under Rule 144.
(j) Except for rights granted to holders of the Warrants, the Company will not, without the written consent of the Majority Holders, grant to any persons the right to request the Company to register any securities of the Company, provided that the Company may grant such registration rights to other persons so long as such rights are subordinate or pari passu to the rights of the Eligible Holders.

 

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9. (a) Subject to the conditions set forth below, the Company agrees to indemnify and hold harmless each Eligible Holder, its officers, directors, partners, employees, agents and counsel, and each person, if any, who controls any such person within the meaning of Section 15 of the Act or Section 20(a) of the Securities Exchange Act of 1934, as amended (the “Exchange Act”), from and against any and all loss, liability, charge, claim, damage, and expense whatsoever (which shall include, for all purposes of this Section 9, but not be limited to, attorneys’ fees and any and all reasonable expense whatsoever incurred in investigating, preparing, or defending against any litigation, commenced or threatened, or any claim whatsoever, and any and all amounts paid in settlement of any claim or litigation), as and when incurred, arising out of, based upon, or in connection with: (i) any untrue statement or alleged untrue statement of a material fact contained (A) in any registration statement, preliminary prospectus, or final prospectus (as from time to time amended and supplemented), or any amendment or supplement thereto, relating to the sale of any of the Registrable Securities, or (B) in any application or other document or communication (in this Section 9 collectively called an “application”) executed by or on behalf of the Company or based upon written information furnished by or on behalf of the Company filed in any jurisdiction in order to register or qualify any of the Registrable Securities under the securities or blue sky laws thereof or filed with the Commission or any securities exchange; or (ii) any omission or alleged omission to state a material fact required to be stated in any document referenced in clause (A) or (B) above or necessary to make the statements therein not misleading, unless such statement or omission was made in reliance upon and in conformity with written information furnished to the Company with respect to such Eligible Holder by or on behalf of such person expressly for inclusion in any registration statement, preliminary prospectus, or final prospectus, or any amendment or supplement thereto, or in any application, as the case may be; or (iii) any breach of any representation, warranty, covenant, or agreement of the Company contained in this Warrant. The foregoing agreement to indemnify shall be in addition to any liability the Company may otherwise have, including liabilities arising under this Warrant.
If any action is brought against any Eligible Holder or any of its officers, directors, partners, employees, agents, or counsel, or any controlling persons of such person (an “indemnified party”) in respect of which indemnity may be sought against the Company pursuant to the foregoing paragraph, such indemnified party or parties shall promptly notify the Company in writing of the institution of such action (but the failure so to notify shall not relieve the Company from any liability other than pursuant to this Section 9(a), except to the extent it may have been prejudiced in any material respect by such failure) and the Company shall promptly assume the defense of such action, including the employment of counsel (reasonably satisfactory to such indemnified party or parties) and payment of expenses. Such indemnified party or parties shall have the right to employ its or their own counsel in any such case, but the fees and expenses of such counsel shall be at the expense of such indemnified party or parties unless the employment of such counsel shall have been authorized in writing by the Company in connection with the defense of such action or the Company shall not have promptly employed counsel reasonably satisfactory to such indemnified party or parties to have charge of the defense of such action or such indemnified party or parties shall have reasonably concluded that there may be one or more legal defenses available to it or them or to other indemnified parties which

 

12


 

are different from or additional to those available to the Company, in any of which events such fees and expenses shall be borne by the Company and the Company shall not have the right to direct the defense of such action on behalf of the indemnified party or parties. Anything in this Section 10 to the contrary notwithstanding, the Company shall not be liable for any settlement of any such claim or action effected without its written consent, which shall not be unreasonably withheld. The Company shall not, without the prior written consent of each indemnified party that is not released as described in this sentence, settle or compromise any action, or permit a default or consent to the entry of judgment in or otherwise seek to terminate any pending or threatened action, in respect of which indemnity may be sought hereunder (whether or not any indemnified party is a party thereto), unless such settlement, compromise, consent, or termination includes an unconditional release of each indemnified party from all liability in respect of such action. The Company agrees promptly to notify the Eligible Holders of the commencement of any litigation or proceedings against the Company or any of its officers or directors in connection with the sale of any Registrable Securities or any preliminary prospectus, prospectus, registration statement, or amendment or supplement thereto, or any application relating to any sale of any Registrable Securities.
(b) The Holder agrees to indemnify and hold harmless the Company, each director of the Company, each officer of the Company who shall have signed any registration statement covering Registrable Securities held by the Holder, each other person, if any, who controls the Company within the meaning of Section 15 of the Act or Section 20(a) of the Exchange Act, and its or their respective counsel, to the same extent as the foregoing indemnity from the Company to the Holder in Section 9(a), but only with respect to statements or omissions, if any, made in any registration statement, preliminary prospectus, or final prospectus (as from time to time amended and supplemented), or any amendment or supplement thereto, or in any application, in reliance upon and in conformity with written information furnished to the Company with respect to the Holder by or on behalf of the Holder expressly for inclusion in any such registration statement, preliminary prospectus, or final prospectus, or any amendment or supplement thereto, or in any application, as the case may be. If any action shall be brought against the Company or any other person so indemnified based on any such registration statement, preliminary prospectus, or final prospectus, or any amendment or supplement thereto, or in any application, and in respect of which indemnity may be sought against the Holder pursuant to this Section 9(b), the Holder shall have the rights and duties given to the Company, and the Company and each other person so indemnified shall have the rights and duties given to the indemnified parties, by the provisions of Section 9(a).
(c) To provide for just and equitable contribution, if (i) an indemnified party makes a claim for indemnification pursuant to Section 9(a) or 9(b) (subject to the limitations thereof) but it is found in a final judicial determination, not subject to further appeal, that such indemnification may not be enforced in such case, even though this Agreement expressly provides for indemnification in such case, or (ii) any indemnified or indemnifying party seeks contribution under the Act, the Exchange Act or otherwise, then the Company (including for this purpose any contribution made by or on behalf of any director of the Company, any officer of the Company who signed any such registration statement, any controlling person of the Company,

 

13


 

and its or their respective counsel), as one entity, and the Eligible Holders of the Registrable Securities included in such registration in the aggregate (including for this purpose any contribution by or on behalf of an indemnified party), as a second entity, shall contribute to the losses, liabilities, claims, damages, and expenses whatsoever to which any of them may be subject, on the basis of relevant equitable considerations such as the relative fault of the Company and such Eligible Holders in connection with the facts which resulted in such losses, liabilities, claims, damages, and expenses. The relative fault, in the case of an untrue statement, alleged untrue statement, omission, or alleged omission, shall be determined by, among other things, whether such statement, alleged statement, omission, or alleged omission relates to information supplied by the Company or by such Eligible Holders, and the parties’ relative intent, knowledge, access to information, and opportunity to correct or prevent such statement, alleged statement, omission, or alleged omission. The Company and the Holder agree that it would be unjust and inequitable if the respective obligations of the Company and the Eligible Holders for contribution were determined by pro rata or per capita allocation of the aggregate losses, liabilities, claims, damages, and expenses (even if the Holder and the other indemnified parties were treated as one entity for such purpose) or by any other method of allocation that does not reflect the equitable considerations referred to in this Section 9(c). In no case shall any Eligible Holder be responsible for a portion of the contribution obligation imposed on all Eligible Holders in excess of its pro rata share based on the number of shares of Common Stock owned (or which would be owned upon exercise of the Registrable Securities) by it and included in such registration as compared to the number of shares of Common Stock owned (or which would be owned upon exercise of the Registrable Securities) by all Eligible Holders and included in such registration. No person guilty of a fraudulent misrepresentation (within the meaning of Section 11(f) of the Act) shall be entitled to contribution from any person who is not guilty of such fraudulent misrepresentation. For purposes of this Section 9(c), each person, if any, who controls any Eligible Holder within the meaning of Section 15 of the Act or Section 20(a) of the Exchange Act and each officer, director, partner, employee, agent, and counsel of each such Eligible Holder or control person shall have the same rights to contribution as such Eligible Holder or control person and each person, if any, who controls the Company within the meaning of Section 15 of the Act or Section 20(a) of the Exchange Act, each officer of the Company who shall have signed any such registration statement, each director of the Company, and its or their respective counsel shall have the same rights to contribution as the Company, subject in each case to the provisions of this Section 9(c). Anything in this Section 9(c) to the contrary notwithstanding, no party shall be liable for contribution with respect to the settlement of any claim or action effected without its written consent. This Section 9(c) is intended to supersede any right to contribution under the Act, the Exchange Act, or otherwise.
10. The issuance of any shares or other securities upon the exercise of this Warrant, and the delivery of certificates or other instruments representing such shares or other securities, shall be made without charge to the Holder for any tax or other charge in respect of such issuance. The Company shall not, however, be required to pay any tax which may be payable in respect of any transfer involved in the issue and delivery of any certificate in a name other than that of the Holder and the Company shall not be required to issue or deliver any such certificate unless and until the person or persons requesting the issue thereof shall have paid to the Company the amount of such tax or shall have established to the satisfaction of the Company that such tax has been paid.

 

14


 

11. Certificates evidencing the Warrant Shares issued upon exercise of the Warrants shall bear the following legend:
“THE SHARES REPRESENTED BY THIS CERTIFICATE HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED. SUCH SHARES MAY NOT BE OFFERED OR SOLD EXCEPT PURSUANT TO AN EFFECTIVE REGISTRATION STATEMENT UNDER SUCH ACT, OR AN EXEMPTION FROM REGISTRATION UNDER SUCH ACT.”
12. Upon receipt of evidence satisfactory to the Company of the loss, theft, destruction, or mutilation of any Warrant (and upon surrender of any Warrant if mutilated), and upon reimbursement of the Company’s reasonable incidental expenses, the Company shall execute and deliver to the Holder thereof a new Warrant of like date, tenor and denomination.
13. The Holder of any Warrant shall not have, solely on account of such status, any rights of a stockholder of the Company, either at law or in equity, or to any notice of meetings of stockholders or of any other proceedings of the Company, except as provided in this Warrant.
14. Any notice or other communication required or permitted to be given hereunder shall be in writing and shall be mailed by certified mail, return receipt requested or sent by Federal Express, Express Mail, or similar overnight delivery or courier service or delivered (in person or by telecopy, telex, or similar telecommunications equipment) against receipt to the party to whom it is to be given, if sent to the Company, at: 157 Surfview Drive, Pacific Palisades, California 90272, Attention: Chief Executive Officer; or if sent to the Holder, at the Holder’s address as it shall appear on the Warrant Register; or to such other address as the party shall have furnished in writing in accordance with the provisions of this Section 14. Any notice or other communication given by certified mail shall be deemed given at the time of certification thereof, except for a notice changing a party’s address which will be deemed given at the time of receipt thereof. Any notice given by other means permitted by this Section 14 shall be deemed given at the time of receipt thereof.
15. This Warrant shall be binding upon the Company and its successors and assigns and shall inure to the benefit of the Holder and its successors and assigns.
16. This Warrant shall be construed in accordance with the laws of the State of California applicable to contracts made and performed within such State, without regard to principles of conflicts of law.
[Remainder of page intentionally left blank; signature page follows.]

 

15


 

17. The Company irrevocably consents to the jurisdiction of the courts of the State of California and of any federal court located in such State in connection with any action or proceeding arising out of or relating to this Warrant, any document or instrument delivered pursuant to, in connection with or simultaneously with this Warrant, or a breach of this Warrant or any such document or instrument. In any such action or proceeding, the Company waives personal service of any summons, complaint or other process.
Dated: _____ __, 2006
         
  [COMPANY]
 
 
   By:      
    Name:      
    Title:      
 

 

16


 

FORM OF ASSIGNMENT
(To be executed by the registered holder if such holder desires to transfer the attached Warrant.)
FOR VALUE RECEIVED, ___hereby sells, assigns, and transfers unto ___a Warrant to purchase shares of Common Stock, par value $.001 per share, of [COMPANY] (the “Company”), together with all right, title, and interest therein, and does hereby irrevocably constitute and appoint ___attorney to transfer such Warrant on the books of the Company, with full power of substitution.
Dated: ________________________
Signature_________________________
NOTICE
The signature on the foregoing Assignment must correspond to the name as written upon the face of this Warrant in every particular, without alteration or enlargement or any change whatsoever.

 

17


 

To:  
[COMPANY]
[ADDRESS]
ELECTION TO EXERCISE
The undersigned hereby exercises its rights to purchase ___Warrant Shares covered by the within Warrant and tenders payment herewith in the amount of $ ___in accordance with the terms thereof, and requests that certificates for such securities be issued in the name of, and delivered to:
 
 
 
 
 
 
 
 
(Print Name, Address and Social Security
or Tax Identification Number)
and, if such number of Warrant Shares shall not be all the Warrant Shares covered by the within Warrant, that a new Warrant for the balance of the Warrant Shares covered by the within Warrant be registered in the name of, and delivered to, the undersigned at the address stated below.
             
Dated:
      Name    
 
           
 
          (Print)
 
           
Address:
           
     
 
           
 
           
 
           
 
          (Signature)

 

18


 

To:  
[COMPANY]
157 Surfview Drive
Pacific Palisades, California 90272
NOTICE OF CASHLESS EXERCISE
(To be executed upon exercise of Warrant
pursuant to Section 1(b))
The undersigned hereby irrevocably elects to exchange its Warrant for ___Warrant Shares pursuant to the cashless exercise provisions of the within Warrant, as provided for in Section 1(b) of such Warrant, and requests that a certificate or certificates for such Warrant Shares be issued in the name of, and delivered to:
 
 
 
 
 
 
 
 
(Print Name, Address and Social Security
or Tax Identification Number)
and, if such number of Warrant Shares shall not be all the Warrant Shares which the undersigned is entitled to purchase in accordance with the within Warrant, that a new Warrant for the balance of the Warrant Shares covered by the within Warrant be registered in the name of, and delivered to, the undersigned at the address stated below.
             
Dated:
      Name    
 
           
 
          (Print)
 
           
Address:
           
     
 
           
 
           
 
           
 
          (Signature)
 
           
 
          (Signature must conform in all respects to the name of the Holder as specified on the face of the Warrant)

 

19

 

Exhibit 10.1

(LIFELINE CELL TECHNOLOGY LOGO)
November 1, 2006
To: Kenneth C. Aldrich
From: International Stem Cell Corporation
Dear Ken:
The following sets for the terms of your proposed employment with International Stem Cell Corporation (“ISCC”). ISCC hereby offers you employment with ISCC on the terms and conditions set forth below, such employment to commence November 1, 2006. As referred to herein, “ISCC” shall include the public entity of which ISCC expects to become a wholly owned subsidiary (the “Parent”) through a pending “reverse merger takeover (the “RTO”) and Lifeline Cell Technology, LLC, as the context requires.
  1.  
You will be Executive Vice President and Assistant Secretary of ISCC and Lifeline and report directly to the Boards of Directors of those entities. Your duties and responsibilities will include the function of forming and chairing at Strategic Advisory Committee and all the responsibilities related there to, together with such other functions as the Board may delegate to you. Responsibilities may be added, removed or otherwise modified, as the Board deems necessary.
 
  2.  
You will serve on the Boards of both ISCC and Lifeline.
 
  3.  
You will receive a base salary of $180,000, payable semi-monthly. Your status will be salary exempt. You will be entitled to 15 days paid vacation each year, accruing on a monthly basis. You will be eligible for coverage under such group health plan and other benefits as the Company provides to comparable employees.
 
  4.  
Employment with ISCC or Parent is at the mutual consent of the employee and the company. Accordingly, while the company has every hope that employment relationships will be mutually beneficial and rewarding, employees and the company retain the right to terminate the employment relationship at will, at any time, with or without cause. Please note that no individual has the authority to make any contrary agreement or representation. Accordingly, this constitutes a final and fully binding integrated agreement with respect to the at-will nature of the employment relationship.
 
  5.  
You agree to abide by the Company’s policies and procedures, including those set forth in a Company Employee Handbook when such document is drafted. You will be required to sign the signature page of this Employee Handbook when it is completed.

 

 


 

(LIFELINE CELL TECHNOLOGY LOGO)
  6.  
For a period of one year after your termination of employment for any reason, you agree not to, directly or indirectly, hire, attempt to hire, induce or entice the hire of or interview for hire any employee of ISCC or Lifeline or any former employee who had been an employee at any time during the one year period prior to your termination.
 
  7.  
You further agree that you will upon termination of employment, return to ISCC and Lifeline all books, records, computer files, manuals, customer lists and other written, typed, printed, or electronic materials, whether furnished by ISCC or Lifeline or prepared by you, which contain any information relating to the ISCC or Lifeline businesses, and you further agree that you will neither make nor retain copies of such materials after termination of employment.
 
  8.  
If you voluntary terminate your employment under this Agreement, you will not, for a period of one year after you are no longer employed by ISCC or Lifeline, solicit customers of ISCC or Lifeline directly or indirectly, either as a proprietor, stockholder, partner, officer, employee, or otherwise of any other entity engaged in the stem cell business in the United States, producing and/or selling same or substantially similar products and services as ISCC or Lifeline produces and/or sells at such time your employment with ISCC and/or Lifeline may terminate.
 
  9.  
In the event of any lawsuit or charge filed with an administrative agency, or other form of litigation brought against or involving you as a result of alleged activity, negligence, or any other conduct by you in connection with your duties and responsibilities on behalf of ISCC or Lifeline, ISCC shall provide and pay for legal defense on your behalf, as well as indemnify you against any judgment or other liability that may result from such proceedings unless such activity or conduct represented willful misconduct on your part.
 
  10.  
You will be required to sign an Employee Proprietary Information Agreement as well as the necessary tax and benefit enrollment forms before starting full time employment. You will also be required to provide proof of your identity and authorization to work in the United States as required by Federal immigration laws.
 
  11.  
Ken, we look forward to you joining our effort and hope the opportunity will be mutually rewarding. To confirm that you agree to the terms stated in this letter, please sign, date and return the enclosed copy of this letter.
Sincerely,
International Stem Cell Corporation

 

 


 

(LIFELINE CELL TECHNOLOGY LOGO)
By:    /S/ JEFFREY KRSTICH   
Jeffrey Krstich CEO
This will acknowledge my acceptance of this offer of employment.
     
/S/KENNETH C. ALDRICH
   
Kenneth C. Aldrich
  Date: November 1, 2006

 

 

 

Exhibit 10.2

(LIFELINE CELL TECHNOLOGY LOGO)
November 1, 2006
To: William B. Adams
From: International Stem Cell Corporation
Dear Bill:
The following sets for the terms of your proposed employment with International Stem Cell Corporation (“ISCC”). ISCC hereby offers you employment with ISCC on the terms and conditions set forth below, such employment to commence November 1, 2006. As referred to herein, “ISCC” shall include the public entity of which ISCC expects to become a wholly owned subsidiary (the “Parent”) through a pending “reverse merger takeover (the “RTO”) and Lifeline Cell Technology, LLC, as the context requires.
  1.  
You will be CFO of ISCC and Lifeline and report directly to the Boards of Directors of those entities. Your duties and responsibilities will include the function of CFO and all the responsibilities related there to. Responsibilities may be added, removed or otherwise modified, as the Board deems necessary.
 
  2.  
You will serve on the Boards of both ISCC and Lifeline.
 
  3.  
You will receive a base salary of $180,000, payable semi-monthly. Your status will be salary exempt. You will be entitled to 15 days paid vacation each year, accruing on a monthly basis. You will be eligible for coverage under such group health plan and other benefits as the Company provides to comparable employees.
 
  4.  
Employment with ISCC or Parent is at the mutual consent of the employee and the company. Accordingly, while the company has every hope that employment relationships will be mutually beneficial and rewarding, employees and the company retain the right to terminate the employment relationship at will, at any time, with or without cause. Please note that no individual has the authority to make any contrary agreement or representation. Accordingly, this constitutes a final and fully binding integrated agreement with respect to the at-will nature of the employment relationship.
 
  5.  
You agree to abide by the Company’s policies and procedures, including those set forth in a Company Employee Handbook when such document is drafted. You will be required to sign the signature page of this Employee Handbook when it is completed.

 

 


 

(LIFELINE CELL TECHNOLOGY LOGO)
  6.  
For a period of one year after your termination of employment for any reason, you agree not to, directly or indirectly, hire, attempt to hire, induce or entice the hire of or interview for hire any employee of ISCC or Lifeline or any former employee who had been an employee at any time during the one year period prior to your termination.
 
  7.  
You further agree that you will upon termination of employment, return to ISCC and Lifeline all books, records, computer files, manuals, customer lists and other written, typed, printed, or electronic materials, whether furnished by ISCC or Lifeline or prepared by you, which contain any information relating to the ISCC or Lifeline businesses, and you further agree that you will neither make nor retain copies of such materials after termination of employment.
 
  8.  
If you voluntary terminate your employment under this Agreement, you will not, for a period of one year after you are no longer employed by ISCC or Lifeline, solicit customers of ISCC or Lifeline directly or indirectly, either as a proprietor, stockholder, partner, officer, employee, or otherwise of any other entity engaged in the stem cell business in the United States, producing and/or selling same or substantially similar products and services as ISCC or Lifeline produces and/or sells at such time your employment with ISCC and/or Lifeline may terminate.
 
  9.  
In the event of any lawsuit or charge filed with an administrative agency, or other form of litigation brought against or involving you as a result of alleged activity, negligence, or any other conduct by you in connection with your duties and responsibilities on behalf of ISCC or Lifeline, ISCC shall provide and pay for legal defense on your behalf, as well as indemnify you against any judgment or other liability that may result from such proceedings unless such activity or conduct represented willful misconduct on your part.
 
  10.  
You will be required to sign an Employee Proprietary Information Agreement as well as the necessary tax and benefit enrollment forms before starting full time employment. You will also be required to provide proof of your identity and authorization to work in the United States as required by Federal immigration laws.
 
  11.  
Bill, we look forward to you joining our effort and hope the opportunity will be mutually rewarding. To confirm that you agree to the terms stated in this letter, please sign, date and return the enclosed copy of this letter.
Sincerely,
International Stem Cell Corporation

 

 


 

(LIFELINE CELL TECHNOLOGY LOGO)
By:    /S/ JEFFREY KRSTICH   
Jeffrey Krstich CEO
This will acknowledge my acceptance of this offer of employment.
     
/S/ WILLIAM B ADAMS
   
William B. Adams
  Date: November 1, 2006

 

 

 

Exhibit 10.3

(LIFELINE CELL TECHNOLOGY LOGO)
March 27, 2006
To: Jeff Krstich
From: Ken Aldrich
Dear Jeff:
Following our conversations of last week, it gives me great pleasure to offer you employment with Lifeline Cell Technology (“Lifeline”), or the public entity of which Lifeline expects to become a wholly owned subsidiary (the “Parent”). This offer is subject to the terms and conditions set forth below and employment shall commence April 1, 2006.
1. Near Term:
For the next 90 days, or until Lifeline completes its exchange of shares to become a subsidiary of Parent and the first round of financing that is to accompany that share exchange, you will have the following duties and compensation:
  a.  
You will identified as and agree to serve as the President and CEO of the Parent, with the understanding that your employment thereby is subject to the completion of both the exchange of Lifeline shares so that it becomes a subsidiary of Parent (or such other method of combining the business of Lifeline and Parent as may be implemented) and the completion of a concurrent financing of Parent in the gross amount of at least $4 million.
 
  b.  
As an inducement to you to forego other employment during this period and to perform the duties described below, Lifeline will issue to you Warrants to purchase equity in Lifeline (or Parent) at the same valuation contained in the Warrants now being offered to the investors funding its current Bridge Loans. You have received a copy of the term sheet for such Loans, which provide that the price of the Warrant will be set at 80% of the market price of the next financing, public or private, of Lifeline or Parent. It is expected that financing will be of the Parent, with Lifeline becoming a subsidiary so that the Warrant will be for 80% of the purchase of shares of the Parent, but if that does not occur, the Warrants will provide for purchase of Lifeline shares as described in the term sheet. The Warrants will have a 3 year term. Lifeline will use its best efforts to arrange to have the shares underlying the Warrant registered concurrently with the registration of the shares issued in the financing of the Parent, but that will be subject to the requirements of the persons or entities providing that initial financing.

 

 


 

(LIFELINE CELL TECHNOLOGY LOGO)
  c.  
The number of Warrants will equal the number of Warrants that would be attached to a third party investment of $25,000 in the current Bridge round for each month that elapses prior to the first funding of Parent. The intent is to give you control over $25,000 worth of equity for each month you work without normal compensation.
 
  d.  
In addition, during interim prior to funding of Parent, Lifeline will, to extent of available funds, pay you a retainer of $5,000 per month, payable bi-weekly. During this interim period you will not be a full time employee, but will allocate such time as is necessary to visit the Lifeline CA and MD facilities, meet with Jeffrey Janus and other employees of Lifeline to familiarize yourself the company so that you can accurately represent it to investors, and attend such pre-funding meetings with prospective investors as may be required to obtain the initial funding for Parent. In the event these duties become more than a part time requirement, Lifeline agrees at your request to consider appropriate adjustments. In the event for any reason Lifeline is not able to make payments during this interim period because of cash flow shortages prior to funding, you will have the choice of accepting deferred payment, payable at funding, or of receiving, subject to any applicable securities laws) Bridge Notes in Lifeline on the same basis as investors in such Notes.
 
  e.  
All travel and other direct expenses incurred in carrying out your duties during the interim period will be promptly reimbursed by Lifeline, provided that any expense in excess of $1000.00 must be pre-approved by Lifeline.
2. After Funding
Upon completion of the funding of the Parent and its acquisition of the shares of Lifeline, you will become CEO and President of the Parent on the following basis:
  a.  
Your full time employment shall begin on the closing date of the first financing of Parent. If that has not occurred within 90 days of the date hereof, any extension shall occur only on terms to be agreed upon by the parties; provided however that if a financing commitment has been obtained, subject to normal market exceptions, and closing is delayed due to the necessity for completion of documentation or other matters beyond the control of he parties, you will agree to a 60 day extension, provided salary payments are made as if this contract had commenced on the 91 st day.
 
  b.  
You will report directly to the Board of Directors of the Parent. Your duties and responsibilities will include leadership and management of the Parent’s operations, general corporate strategy, acquisitions strategy and management of the Parent in the public marketplace. Responsibilities may be added, removed or otherwise modified,

 

 


 

(LIFELINE CELL TECHNOLOGY LOGO)
     
as the Board deems necessary. It is expected that Jeffrey Janus will continue to be the President and CEO of Lifeline as a subsidiary of Parent and report directly to its Board and to the Board of Parent and that you and he will function in collaboration rather than in a senior/subordinate role. At such time as Lifeline ceases to be a wholly owned subsidiary, these roles may be modified as needed.
 
  c.  
You will serve on the Boards of both the Parent and Lifeline.
 
  d.  
You will receive a base salary of $220,000, payable semi-monthly. Your status will be salary exempt. You will be entitled to 15 days paid vacation each year, accruing on a monthly basis. You will be eligible for coverage under such group health plan and other benefits as the Company provides to comparable employees, as they are established. (A group health plan is now being established and is expected to be in place prior to your commencement date. You will be paid a bonus of $50,000 if the stock of Parent reaches and is maintained at a level of 50% or more above the initial offering price.
 
  e.  
You will receive at commencement of full time employment employee stock options on sufficient shares of common stock to enable you to control the amount of common stock you could purchase (at the initial offering price) with 2 times your annual base salary. Thus, if the initial offering price were $1/share, you would be granted options to purchase 440,000 shares. Options will vest monthly over a 4-year term. If the security issued in the initial offering is a convertible security, the conversion price thereof shall be used to determine the number of shares of common stock subject to this paragraph. You will be eligible for future stock option awards based on performance and results.
 
  f.  
You will relocate upon funding to San Diego County, California. Your actual moving expenses will be reimbursed up to a maximum of $25,000.
 
  g.  
Employment with Lifeline or Parent is at the mutual consent of the employee and the company. Accordingly, while the company has every hope that employment relationships will be mutually beneficial and rewarding, employees and the company retain the right to terminate the employment relationship at will, at any time, with or without cause. However, termination pay equal to 6 months of the initial base salary shall be paid in the event of termination by the company for any reason other that “for cause”, as customarily defined. Please note that no individual has the authority to make any contrary agreement or representation. Accordingly, this constitutes a final and fully binding integrated agreement with respect to the at-will nature of the employment relationship.
 
  h.  
You agree to abide by the Company’s policies and procedures, including those set forth in a Company Employee Handbook when such document is drafted. You will be required to sign the signature page of this Employee Handbook when it is completed.

 

 


 

(LIFELINE CELL TECHNOLOGY LOGO)
  i.  
You will be required to sign an Employee Proprietary Information Agreement as well as the necessary tax and benefit enrollment forms before starting full time employment. You will also be required to provide proof of your identity and authorization to work in the United States as required by Federal immigration laws.
Jeff, we look forward to you joining our effort and hope the opportunity will be mutually rewarding. To confirm that you agree to the terms stated in this letter, please sign, date and return the enclosed copy of this letter.
Sincerely,
Lifeline Cell Technology, LLC
/S/ Kenneth C. Aldrich
Kenneth C. Aldrich
Chairman of the Board
 
This will acknowledge my acceptance of this offer of employment.
     
/S/ JEFF KRSTICH
 
  MARCH 29, 2006 
Jeff Krstich
  Date

 

 

 

Exhibit 10.4
(LIFELINE LOGO)
October 31, 2006
To:    Jeffrey Janus
From:    International Stem Cell Corporation
Dear Jeff:
The following sets for the terms of your proposed employment with International Stem Cell Corporation (“ISCC”). ISCC hereby offers you employment with ISCC on the terms and conditions set forth below, such employment to commence October 31, 2006. As referred to herein, “ISCC” shall include the public entity of which ISCC expects to become a wholly owned subsidiary (the “Parent”) through a pending “reverse merger takeover (the “RTO”) and Lifeline Cell Technology, LLC, as the context requires.
  1.  
You will be President of ISCC and Lifeline and report directly to the Boards of Directors of those entities. Your duties and responsibilities will include leadership and management of the ISCC’s and Lifeline’s research and product development, marketing, product production, and sales. Responsibilities may be added, removed or otherwise modified, as the Board deems necessary. It is expected that Jeff Krstich will continue to be the CEO of ISCC and that you and he will function in collaboration rather than in a senior/subordinate role. At such time as Lifeline ceases to be a wholly owned subsidiary, these roles may be modified as needed.
 
  2.  
You will serve on the Boards of both ISCC and Lifeline.
  3.  
You will receive a base salary of $220,000, payable semi-monthly. Your status will be salary exempt. In anticipation of your collaborative relationship to the CEO, your base salary shall at all times during the 24 months hereafter be not less than that paid to the CEO of ISCC, but bonuses may be based on different standards reflecting your differing areas of primary responsibility. You will be entitled to 15 days paid vacation each year, accruing on a monthly basis. You will be eligible for coverage under such group health plan and other benefits as the Company provides to comparable employees, as they are established. (A group health plan is now being established and is expected to be in place prior to your commencement date. You will be paid a bonus of $50,000 on or before December 31, 2007 if milestones mutually agreed between you and Board of ISCC are met. Because you are already a significant shareholder, you will not receive any additional stock options at commencement of employment, but will be eligible for future stock option awards based on performance and results as President of ISCC and Lifeline without regard or deduction for your existing stock ownership. Options will vest monthly over a 4-year term.

 

 


 

(LIFELINE LOGO)
  4.  
If you are requested to relocate to San Diego County, California. Your actual moving expenses will be reimbursed up to a maximum of $25,000. Additional reasonable relocation expenses incurred by you may be reimbursed to you upon consideration and approval by the Board of Directors of Lifeline. In the event that you are required to move a second time, ISCC will pay all reasonable moving costs associated with such move and, if such move is required within 2 years of your move to San Diego County, ISCC will reimburse you for your moving costs and any actual loss in value upon the sale of your home in San Diego County in an amount not to exceed $200,000, provided such home is placed on the market at or near the time of such relocation.
  5.  
Employment with ISCC or Parent is at the mutual consent of the employee and the company. Accordingly, while the company has every hope that employment relationships will be mutually beneficial and rewarding, employees and the company retain the right to terminate the employment relationship at will, at any time, with or without cause. However, termination pay equal to 12 months of the initial base salary shall be paid in the event of termination by the company for any reason other than “for cause”, as customarily defined. Please note that no individual has the authority to make any contrary agreement or representation. Accordingly, this constitutes a final and fully binding integrated agreement with respect to the at-will nature of the employment relationship. How will the termination pay be paid? Over time, lump sum?
  6.  
You agree to abide by the Company’s policies and procedures, including those set forth in a Company Employee Handbook when such document is drafted. You will be required to sign the signature page of this Employee Handbook when it is completed.
  7.  
For a period of one year after your termination of employment for any reason, you agree not to, directly or indirectly, hire, attempt to hire, induce or entice the hire of or interview for hire any employee of ISCC or Lifeline or any former employee who had been an employee at any time during the one year period prior to your termination.
  8.  
You further agree that you will upon termination of employment, return to ISCC and Lifeline all books, records, computer files, manuals, customer lists and other written, typed, printed, or electronic materials, whether furnished by ISCC or Lifeline or prepared by you, which contain any information relating to the ISCC or Lifeline businesses, and you further agree that you will neither make nor retain copies of such materials after termination of employment.

 

 


 

(LIFELINE LOGO)
  9.  
If you voluntary terminate your employment under this Agreement, you will not, for a period of one year after you are no longer employed by ISCC or Lifeline, solicit customers of ISCC or Lifeline directly or indirectly, either as a proprietor, stockholder, partner, officer, employee, or otherwise of any other entity engaged in the stem cell business in the United States, producing and/or selling same or substantially similar products and services as ISCC or Lifeline produces and/or sells at such time your employment with ISCC and/or Lifeline may terminate.
  10.  
In the event of any lawsuit or charge filed with an administrative agency, or other form of litigation brought against or involving you as a result of alleged activity, negligence, or any other conduct by you in connection with your duties and responsibilities on behalf of ISCC or Lifeline, ISCC shall provide and pay for legal defense on your behalf, as well as indemnify you against any judgment or other liability that may result from such proceedings unless such activity or conduct represented willful misconduct on your part.
  11.  
You will be required to sign an Employee Proprietary Information Agreement as well as the necessary tax and benefit enrollment forms before starting full time employment. You will also be required to provide proof of your identity and authorization to work in the United States as required by Federal immigration laws.
  12.  
Jeffrey, we look forward to you joining our effort and hope the opportunity will be mutually rewarding. To confirm that you agree to the terms stated in this letter, please sign, date and return the enclosed copy of this letter.
Sincerely,
International Stem Cell Corporation
By:      /S/ KENNETH C. ADLRICH     
Kenneth C. Aldrich
Chairman of the Board
This will acknowledge my acceptance of this offer of employment.
     
/S/ JEFFREY JANUS
   
Jeffrey Janus
  Date:      October 31, 2006     

 

 

 

Exhibit 10.5

FINANCIAL ADVISORY AGREEMENT
THIS FINANCIAL ADVISORY AGREEMENT (“Agreement” or “FAA”) is made and entered into on this the 18th day of October, 2006, by and between Halter Financial Group, L.P., a Texas limited partnership (“HFG”), and International Stem Cell Corporation, a California corporation (the “Company”).
W I T N E S S E T H:
WHEREAS, the Company desires to engage HFG to provide certain financial advisory and consulting services as specifically enumerated below commencing as of the date hereof related to the Going Public Transaction and the Post-Transaction Period (each as hereinafter defined), and HFG is willing to be so engaged.
NOW, THEREFORE, for and in consideration of the covenants set forth herein and the mutual benefits to be gained by the parties hereto, and other good and valuable consideration, the receipt and adequacy of which are now and forever acknowledged and confessed, the parties hereto hereby agree and intend to be legally bound as follows:
1.  Retention . As of the date hereof, the Company hereby retains and HFG hereby agrees to be retained as the Company’s financial advisor during the term of this Agreement. The Company acknowledges that HFG shall have the right to engage third parties to assist it in its efforts to satisfy its obligations hereunder. In its capacity as a financial advisor to the Company, HFG will:
A. Going Public Transaction.
Assist the Company in evaluating the manner of effecting a going public transaction with a public shell corporation (“Pubco”) domiciled in the United States of America and quoted on the “OTC BB” (a “Going Public Transaction”). It is anticipated that (a) upon consummation of the Going Public Transaction, (b) the closing of the Company’s current private placement of securities (the “Company Offering”) and (c) the closing of the private placement of Pubco (the “Pubco Offering”) contemplated to be undertaken immediately upon the closing of the Going Public Transaction, which together with the Company Offering will generate estimated gross offering proceeds of $10,000,000, the Company’s current stockholders, investors in the Company Offering and the Pubco Offering, respectively, will hold 93.5% of all the issued and outstanding shares of Pubco’s common capital stock.
Specifically, ownership by the former shareholders of Pubco following the Going Public Transaction and the Pubco offering shall therefore consist of 2,210,000 shares of common stock. Ownership of the balance of Pubco common stock shall be held as follows: approximately 21,790,000 shares of common stock will be held by the Company’s shareholders immediately prior to such transactions, and an estimated 10,000,000 shares will be issued to investors in the Pubco Offering, a total of approximately 34,000,000 shares. In order to permit the completion of share splits or

 

FINANCIAL ADVISORY AGREEMENT - Page 1

 

 


 

other capital structure adjustments to Pubco that may be required prior to closing, no adjustment in the shares to be held by the initial Pubco shareholders shall be made for the possible oversubscription or undersubscription of the Pubco Offering by Brookstreet Securities, the Company’s placement agent.
B. Post Transaction Period
Upon consummation of the Going Public Transaction, HFG agrees to:
(i) assist Pubco in obtaining a new CUSIP number and a new stock symbol upon the changing of its name;
(ii) if necessary, coordinate with the Company’s legal counsel the preparation and assembly of application materials for the listing of Pubco’s common stock on a national stock exchange; and
(iii) provide Pubco with such additional financial advisory services as may be reasonably requested, to the extent HFG has the expertise or legal right to render such services.
C. Tax Considerations
The Going Public Transaction shall be accomplished in a manner determined to the satisfaction of the Company to be a tax deferred transaction under the Internal Revenue Code, it being anticipated that the form of transaction shall consist of an exchange of the outstanding shares of the Company for newly issued shares of Pubco.
2.  Authorization . Subject to the terms and conditions of this Agreement, the Company hereby appoints HFG to act on a best efforts basis as its consultant during the Authorization Period (as hereinafter defined). HFG hereby accepts such appoint, with it being expressly acknowledged that HFG is acting in the capacity of independent contractor and not as agent of either the Company, affiliates of the Company or Pubco.
3.  Authorization Period . HFG’s engagement hereunder shall become effective on the date hereof (the “Effective Date”) and will automatically terminate (the “Termination Date”) on the first to occur of the following: (a) 60 days from the Effective Date in the event the Going Public Transaction has not been completed, (b) the mutual decision of the parties not to move forward with the Going Public Transaction or (c) 12 months from the Effective Date.
4.  Fees and Expenses . In consideration for the services to be provided for hereunder the Company shall pay to HFG the amount of $450,000 (the “Fee”) to be paid on the closing date of the Going Public Transaction. The Company shall be under no obligation to pay any part of the Fee to HFG in the event this Agreement is terminated as a result of the failure of the Company and Pubco to effect the Going Public Transaction.
5.  Due Diligence . The Company shall have the right to perform a due diligence investigation of Pubco and shall be under no obligation to effect the Going Public Transaction unless it is satisfied, in its sole discretion, with the results of its diligence investigation.
FINANCIAL ADVISORY AGREEMENT - Page 2

 

 


 

6.  Indemnification . The parties hereto shall indemnify each other to the extent provided for in this paragraph. Except as a result of an act of gross negligence or willful misconduct on the part of a party hereto, no party shall be liable to another party, or its officers, directors, employees, shareholders or affiliates, for any damages sustained as a result of an act or omission taken or made under this Agreement. In those cases where gross negligence or willful misconduct of a party is alleged and proven, the non-damaged party agrees to defend, indemnify and hold the damaged party harmless from and against any and all reasonable costs, expenses and liabilities suffered or sustained as a result of the act of gross negligence or willful misconduct.
7.  Lock Up . HFG agrees that, without the prior written consent of the Company, it will not sell, transfer or otherwise dispose of greater than 1/12 th of its holdings in Pubco every 30 days commencing on the closing date of the Going Public Transaction. However, in the event HFG does not sell or otherwise dispose of all of the allotted number of Pubco shares that may be sold in a given 30 day period, HFG may sell such unsold shares at any time thereafter.
8. Governing Law . This Agreement shall be governed by the laws of the State of Texas.
IN WITNESS WHEREOF, the parties have executed this Agreement as of the day and year first above written.
     
 
  HFG:
 
   
 
  Halter Financial Group, L.P.
 
   
 
  By: [TIMOTHY P. HALTER]
 
       Timothy P. Halter, Chairman, Halter
 
  Financial Group GP, LLC, its General Partner
 
   
 
  The Company:
 
  International Stem Cell Corporation
 
   
 
  By: [KENNETH C. ALDRICH]
 
  Name: Kenneth C. Aldrich
 
  Its: Chairman
FINANCIAL ADVISORY AGREEMENT - Page 3

 

 

 

Exhibit 10.6

(CAPTIAL GROUP COMMUNICATIONS LOGO)
CONSULTING AGREEMENT
This Consulting Agreement (the “Agreement”), effective as of September 1, 2006 , is entered into by and between, International Stem Cell, Inc., (herein referred to as the “Company”) and CAPITAL GROUP COMMUNICATIONS, INC., a California corporation (herein referred to as the “Consultant”).
RECITALS
WHEREAS , Company is; and
WHEREAS , Company desires to engage the services of Consultant to represent the company in investors’ communications and public relations with existing shareholders, brokers, dealers and other investment professionals as to the Company’s current and proposed activities, and to consult with management concerning such Company activities;
NOW THEREFORE , in consideration of the promises and the mutual covenants and agreements hereinafter set forth, the parties hereto covenant and agree as follows:
1)  
Term of Consultancy . Company hereby agrees to retain the Consultant to act in a consulting capacity to the Company, and the Consultant hereby agrees to provide services to the Company commencing once this contract has been executed and ending 12 month thereafter.
 
2)  
Duties of Consultant. The Consultant agrees that it will generally provide the following specified consulting services:
  a)  
Assist the Company in raising capital through introductions. (It is understood CGC is not an “investment banking” firm);
 
  b)  
Consult and assist the Company in developing and implementing appropriate plans and means for presenting the Company and its business plans, strategy and personnel to the financial community, establishing an image for the Company in the financial community, and creating the foundation for subsequent financial public relations efforts;
 
  c)  
Introduce the Company to the financial community;
 
  d)  
With the cooperation of the Company, maintain an awareness during the term of this Agreement of the Company’s plans, strategy and personnel, as they may evolve during such period, and consult and assist the Company in communicating appropriate information regarding such plans, strategy and personnel to the financial community;
 
  e)  
Assist and consult the Company with respect to its (i) relations with stockholders, (ii) relations with brokers, dealers, analysts and other investment professionals, and (iii) financial public relations generally;

 

1.


 

  f)  
Upon the Company’s direction and approval, disseminate information regarding the Company to shareholders, brokers, dealers, other investment community professionals and the general investing public;
 
  g)  
Upon the Company’s approval, conduct meetings, in person or by telephone, with brokers, dealers, analysts and other investment professionals to communicate with them regarding the Company’s plans, goals and activities
 
  h)  
At the Company’s request, review business plans, strategies, mission statements budgets, proposed transactions and other plans for the purpose of advising the Company of the public relations implications thereof; and,
 
  i)  
Work and contract with other consultants/ companies to perform additional Investor Relations services
 
  j)  
Otherwise perform as the Company’s consultant to disseminate information and relations with financial professionals and potential shareholders.
3)  
Allocation of Time and Energies. The Consultant hereby promises to perform and discharge faithfully the responsibilities which may be assigned to the Consultant from time to time by the officers and duly authorized representatives of the Company in connection with the conduct of its financial and public relations and communications activities, so long as such activities are in compliance with applicable securities laws and regulations. Consultant and staff shall diligently and thoroughly provide the consulting services required hereunder. Although no specific hours-per-day requirement will be required, Consultant and the Company agree that Consultant will perform the duties set forth herein above in a diligent and professional manner. The parties acknowledge and agree that a disproportionately large amount of the effort to be expended and the costs to be incurred by the Consultant and the benefits to be received by the Company are expected to occur within or shortly after the first two months of the effectiveness of this Agreement. It is explicitly understood that Consultant’s performance of its duties hereunder will in no way be measured by the price of the Company’s common stock, nor the trading volume of the Company’s common stock. It is also understood that the Company is entering into this Agreement with Capital Group Communications, Inc. (“CGC”), a corporation and not any individual member of CGC, as such, Consultant will not be deemed to have breached this Agreement if any member, officer or director of CGC leaves the firm or dies or becomes physically unable to perform any meaningful activities during the term of the Agreement, provided the Consultant otherwise performs its obligations under this Agreement.
 
4)  
Remuneration. As full and complete compensation for services described in this Agreement, the Company shall compensate CGC as follows:
  a)  
For undertaking this engagement and for other good and valuable consideration, the Company agrees to issue and deliver to the Consultants a “Commencement Bonus” payable in the form of 1,000,000 shares the Company’s Common Stock (“Common Stock”). This Commencement Bonus shall be issued to the Consultant immediately following execution of this Agreement and shall, when issued and delivered to Consultant, be fully paid and non-assessable. The Company understands and agrees that Consultant has foregone significant opportunities to accept this engagement and that the Company derives substantial benefit from the execution of this Agreement and the ability to announce its relationship with Consultant. The shares of Common Stock issued as a Commencement Bonus, therefore, constitute payment for Consultant’s agreement to consult to the

 

2.


 

     
Company and are a nonrefundable, non-apportionable, and non-ratable retainer; such shares of common stock are not a prepayment for future services. If the Company decides to terminate this Agreement prior to end date for any reason whatsoever, it is agreed and understood that Consultant will not be requested or demanded by the Company to return any of the shares of Common Stock paid to it as Commencement Bonus hereunder. Further, if and in the event the Company is acquired in whole or in part, during the term of this agreement, it is agreed and understood Consultant will not be requested or demanded by the Company to return any of the shares of Common stock paid to it hereunder. It is further agreed that if at any time during the term of this agreement, the Company or substantially all of the Company’s assets are merged with or acquired by another entity, or some other change occurs in the legal entity that constitutes the Company, the Consultant shall retain and will not be requested by the Company to return any of the shares. The Company further agrees that all shares issued to Consultant hereunder shall carry “piggyback registration rights” whereby such shares will be included in the next registration statement filed by the company after the first registration other than a registration on Form S-8 with respect to the Company’s Stock Option or Equity Participation Plan.
  b)  
With each transfer of shares of Common Stock to be issued pursuant to this Agreement (collectively, the “Shares”), Company shall cause to be issued a certificate representing the Common Stock and a written opinion of counsel for the Company stating that said shares are validly issued, fully paid and non-assessable and that the issuance and eventual transfer of them to Consultant has been duly authorized by the Company. Company warrants that all Shares issued to Consultant pursuant to this Agreement shall have been validly issued, fully paid and non-assessable and that the issuance and any transfer of them to Consultant shall have been duly authorized by the Company’s board of directors.
 
  c)  
Consultant acknowledges that the shares of Common Stock to be issued pursuant to this Agreement (collectively, the “Shares”) have not been registered under the Securities Act of 1933, and accordingly are “restricted securities” within the meaning of Rule 144 of the Act. As such, the Shares may not be resold or transferred unless the Company has received an opinion of counsel reasonably satisfactory to the Company that such resale or transfer is exempt from the registration requirements of that Act.
 
  d)  
In connection with the acquisition of Shares hereunder, the Consultant represents and warrants to the Company, to the best of its/his knowledge, as follows:
  i)  
Consultant acknowledges that the Consultant has been afforded the opportunity to ask questions of and receive answers from duly authorized officers or other representatives of the Company concerning an investment in the Shares, and any additional information which the Consultant has requested.
 
  ii)  
Consultant has had experience in investments in restricted and publicly traded securities, and Consultant has had experience in investments in speculative securities and other investments which involve the risk of loss of investment. Consultant acknowledges that an investment in the Shares is speculative and involves the risk of loss. Consultant has the requisite knowledge to assess the relative merits and a of this investment without the necessity of relying upon other advisors, and Consultant can afford the risk of loss of his entire investment in the Shares.

 

3.


 

5)  
Financing “Finder’s Fee” . It is understood that in the event Consultant introduces Company, or its nominees, to a lender or equity purchaser, not already having a preexisting relationship with the Company, with whom Company, or its nominees, ultimately finances or causes the completion of such financing, Company agrees to compensate Consultant for such services with a “finder’s fee” in the amount of 5.0% of total gross funding provided by such lender or equity purchaser, such fee to be payable in cash. This 5.0% will be in addition to any fees payable by Company to any other intermediary, if any, which shall be the subject of separate agreements, negotiated between Company and such other intermediary. It is also understood that in the event Consultant introduces Company, or its nominees, to an acquisition candidate not already having a preexisting relationship with the Company, which Company, or its nominees, ultimately acquires or causes the completion of such acquisition, Company agrees to compensate Consultant for such services with a “finder’s fee” in the amount of 5% of total gross consideration provided by such acquisition, such fee to be payable in cash. This 5% will be in addition to any fees payable by Company to any other intermediary. It is specifically understood that Consultant is not and does not hold itself out be a Broker/Dealer, but is rather merely a “Finder” in reference to the Company procuring financing sources and acquisition candidates. Any obligation to pay a “Finder’s Fee” hereunder shall survive the merging, acquisition, or other change in the form of entity of the Company and to the extent it remains unfulfilled shall be assigned and transferred to any successor to the Company.
  a)  
It is further understood that Company, and not Consultant, is responsible to perform any and all due diligence on such lender, equity purchaser or acquisition candidate introduced to it by Consultant under this Agreement, prior to Company receiving funds or closing on any acquisition. However, Consultant will not introduce any parties to Company about which Consultant has any prior knowledge of questionable, unethical or illicit activities.
 
  b)  
Company agrees that said compensation to Consultant shall be paid in full at the time said financing or acquisition is closed, such compensation to be transferred by Company to Consultant within seven (7) business days of the execution of the financing of acquisition closing document. Payment of said compensation, shall be a condition precedent to the closing of such financing or acquisition, and Company shall execute any and all documents necessary to effect said compensation.
 
  c)  
As further consideration to Consultant, Company, or its nominees, agrees to pay with respect to any financing or acquisition candidate provided directly or indirectly to the Company by any lender or equity purchaser covered by this Section 5 during the period of one year from the close of the term of this Agreement, a fee to Consultant equal to that outlined in Section 5 herein; provided, however, that this subsection shall not restrict the Company from hiring an investment banker or broker to obtain financing for the Company, and no fee shall be payable if such banker or broker should independently obtain financing from a financing source previously introduced by Consultant.

 

4.


 

  d)  
Consultant will notify Company of introductions it makes for potential sources of financing or acquisitions in a timely manner (within approximately 3 days of introduction) via facsimile memo. If Company has a preexisting relationship with such nominee and believes such party should be excluded from this Agreement, then Company will notify Consultant immediately within twenty-four (24) hours of Consultant’s facsimile to Company of such circumstance via facsimile memo. To avoid inadvertent interference with the Company’s own joint venture development efforts, Consultant will not contact any pharmaceutical companies, cell biology companies or other companies in the Company’s market arena without prior approval by the Company.
6)  
Non-Assignability of Services . Consultant’s services under this contract are offered to Company only and may not be assigned by Company to any entity with which Company merges or which acquires the Company or substantially all of its assets. In the event of such merger or acquisition, all compensation to Consultant herein under the schedules set forth herein shall remain due and payable, and any compensation received by the Consultant may be retained in the entirety by Consultant, all without any reduction or pro-rating and shall be considered and remain fully paid and non-assessable. Notwithstanding the non-assignability of Consultant’s services, Company shall assure that in the event of any merger, acquisition, or similar change of form of entity, that its successor entity shall agree to complete all obligations to Consultant, including the provision and transfer of all compensation herein, and the preservation of the value thereof consistent with the rights granted to Consultant by the Company herein, and to Shareholders.
 
7)  
Expenses . Consultant agrees to pay for all its expenses (phone, mailing, labor, etc.), other than extraordinary items (travel required by/or specifically requested by the Company, luncheons or dinners to large groups of investment professionals, mass faxing to a sizable percentage of the Company’s constituents, investor conference calls, print advertisements in publications, etc.) approved by the Company prior to its incurring an obligation for reimbursement.
 
8)  
Indemnification. The Company warrants and represents that all oral communications, written documents or materials furnished to Consultant by the Company with respect to financial affairs, operations, profitability and strategic planning of the Company are accurate and Consultant may rely upon the accuracy thereof without independent investigation. The Company will protect, indemnify and hold harmless Consultant against any claims or litigation including any damages, liability, cost and reasonable attorney’s fees as incurred with respect thereto resulting from Consultant’s communication or dissemination of any said information, documents or materials.
 
9)  
Representations . Consultant represents that it is not required to maintain any licenses and registrations under federal or any state regulations necessary to perform the services set forth herein. Consultant acknowledges that, to the best of its knowledge, the performance of the services set forth under this Agreement will not violate any rule or provision of any regulatory agency having jurisdiction over Consultant. Consultant acknowledges that, to the best of its knowledge, Consultant and its officers and directors are not the subject of any investigation, claim, decree or judgment involving any violation of the SEC or securities laws. Consultant further acknowledges that it is not a securities Broker Dealer or a registered investment advisor. Company acknowledges that, to the best of its knowledge, that it has not violated any rule or provision of any regulatory agency having jurisdiction over the Company. Company acknowledges that, to the best of its knowledge, Company is not the subject of any investigation, claim, decree or judgment involving any violation of the SEC or securities laws.

 

5.


 

10)  
Legal Representation . The Company acknowledges that it has been represented by independent legal counsel in the preparation of this Agreement. Consultant represents that it has consulted with independent legal counsel and/or tax, financial and business advisors, to the extent the Consultant deemed necessary.
 
11)  
Status as Independent Contractor . Consultant’s engagement pursuant to this Agreement shall be as independent contractor, and not as an employee, officer or other agent of the Company. Neither party to this Agreement shall represent or hold itself out to be the employer or employee of the other. Consultant further acknowledges the consideration provided hereinabove is a gross amount of consideration and that the Company will not withhold from such consideration any amounts as to income taxes, social security payments or any other payroll taxes. All such income taxes and other such payment shall be made or provided for by Consultant and the Company shall have no responsibility or duties regarding such matters. Neither the Company nor the Consultant possesses the authority to bind each other in any agreements without the express written consent of the entity to be bound.
 
12)  
Attorney’s Fee . If any legal action or any arbitration or other proceeding is brought for the enforcement or interpretation of this Agreement, or because of an alleged dispute, breach, default or misrepresentation in connection with or related to this Agreement, the successful or prevailing party shall be entitled to recover reasonable attorneys’ fees and other costs in connection with that action or proceeding, in addition to any other relief to which it or they may be entitled.
 
13)  
Waiver. The waiver by either party of a breach of any provision of this Agreement by the other party shall not operate or be construed as a waiver of any subsequent breach by such other party.
 
14)  
Choice of Law, Jurisdiction and Venue. This Agreement shall be governed by, construed and enforced in accordance with the laws of the State of California. The parties agree that San Francisco County, CA. will be the venue of any dispute and will have jurisdiction over all parties.
 
15)  
Arbitration. Any controversy or claim arising out of or relating to this Agreement, or the alleged breach thereof, or relating to Consultant’s activities or remuneration under this Agreement, shall be settled by binding arbitration in California, in accordance with the applicable rules of JAMS Endispute, San Francisco, California, and judgment on the award rendered by the arbitrator(s) shall be binding on the parties and may be entered in any court having jurisdiction as provided by Paragraph 14 herein. The provisions of Title 9 of Part 3 of the California Code of Civil Procedure, including section 1283.05, and successor statutes, permitting expanded discovery proceedings shall be applicable to all disputes that are arbitrated under this paragraph.
 
16)  
Complete Agreement. This Agreement contains the entire agreement of the parties relating to the subject matter hereof. This Agreement and its terms may not be changed orally but only by an agreement in writing signed by the party against whom enforcement of any waiver, change, modification, extension or discharge is sought.

 

6.


 

AGREED TO:
         
“Company”   International Stem Cell,
 
       
Date:
  By:   /S/ KENNETH C. ALDRICH
 
       
 
      Kenneth C. Aldrich, Chairman
 
       
“Consultant”   CAPITAL GROUP COMMUNICATIONS, INC.
 
       
Date:
  By:   /S/ DEVIN BOSCH
 
       
 
      Devin Bosch, President

 

7.

 

Exhibit 10.7

CONFIDENTIAL
Lifeline/ASC Final Settlement Agreement
This Final Settlement Agreement is entered into effective as of June 30, 2006 between, on the one hand, each of the “ASC Parties” (which include American Stem Cell Corporation Kenneth Swaisland, Ken Sorensen, Milton Datsopoulos, Michael McClain, Array Capital, Catalytix LDC, Catalytix Life Sciences Hedge, Avion Holdings, Inc., jointly and severally), and, on the other hand, the “Lifeline Parties” (which include Lifeline Cell Technology, LLC, Jeffrey Janus, William B. Adams, Kenneth C. Aldrich, jointly and severally). Both sides collectively are “the Parties”, and references to the Parties are intended as references to them jointly and severally, as well as their respective parent companies, subsidiaries, affiliates, and sister entities, and their respective shareholders, partners, members, directors, officers, managers and employees, and their respective attorneys, insurers, agents, representatives, predecessors, successors and assigns.
Background, Purpose, and Interpretation
1.  Background Facts . The Parties acknowledge these facts: Prior to May 15, 2006, various of the ASC Parties and the Lifeline Parties engaged in various negotiations and entered into various agreements. The last of those agreements was an Extension Agreement providing for certain transactions to be closed on or before May 15, 2006, and for certain releases by ASC Parties of rights and claims against Lifeline Parties to take effect if the closing did not occur. The closing did not occur. The ASC Parties and the Lifeline Parties dispute the legal effect of that failure to close and of those releases; certain of the ASC Parties allege that they were induced by fraud to give the releases contained in the Extension Agreement; the Lifeline Parties deny any fraud.
2.  Purpose; No Admission . To avoid the uncertainties and costs of litigation, the Parties now wish to resolve all known, unknown, suspected and unsuspected claims between them, finally and forever, and they enter into this Final Settlement Agreement for that purpose. The Parties intend this Final Settlement Agreement to be the complete and final statement of the rights and obligations of the ASC Parties and the Lifeline Parties as against one another, superseding, replacing and extinguishing all rights and obligations of every kind and character as between them, excepting only those which are expressly set forth in this Final Settlement Agreement. This Final Settlement Agreement does not constitute an admission by any of the Parties that they engaged in any wrongdoing of any kind.
3.  Prevention of Avoidance of Enforcement . To prevent (to the greatest extent permitted by law) any later claim that this very Final Settlement Agreement was procured by fraud or mistake, or is otherwise unenforceable according to its terms, the Parties represent, warrant and agree that they have not been induced to enter into this Final Settlement Agreement by any belief, understanding, representation, warranty, agreement, act or omission that is not expressly set forth in this Final Settlement Agreement, and further that no belief, understanding, representation, warranty, agreement, act or omission is material to this Final Settlement Agreement or the Parties’ respective decisions to enter into it, excepting only those which are expressly set forth in this Final Settlement Agreement.
Lifeline/ASC Final Settlement Agreement — Page 1 of 9

 

 


 

CONFIDENTIAL
4.  Limitation on Future Claims and Remedies . The Parties further agree that (to the greatest extent permitted by law) any later claim that this Final Settlement Agreement has been entered into by mistake or fraud or was breached or that consideration failed, and any other claim relating to the formation, interpretation, or performance of this Final Settlement Agreement, shall not be construed to permit the rescission of this Final Settlement Agreement or the restoration of any rights or obligations that may have existed between the ASC Parties and the Lifeline Parties prior to the effective date of this Final Settlement Agreement, but instead shall be construed to stipulate that this Final Settlement Agreement is valid and enforceable according to its terms and shall be limited to the claims and remedies expressly stated herein or otherwise available for breach or enforcement of this Final Settlement Agreement.
New Rights and Obligations
5.  Transfer Shares to ASC . All shares of ASC now owned or held by any Lifeline Parties (being fifteen million five hundred thousand (15,500,000) shares) shall be transferred to ASC.
6.  Amended and Restated Debt . All promissory notes issued by Lifeline in favor of ASC, and all other debt owed by Lifeline to ASC, shall be modified and amended and restated, such that Lifeline shall issue a new amended and restated promissory note to ASC in the amount of US $500,000.00, with the terms and in the form attached hereto as Exhibit A .
7.  Good-Faith Cooperation . The Parties agree to cooperate with one another and to take such actions as are reasonably necessary to effectuate this Final Settlement Agreement, at no cost to the other. This includes, without limitation, prompt execution and delivery of all documents necessary to effectuate the transfer of stock, extinguishing of debt, and issuance of a new promissory note referenced above in Sections 5 and 6 , consent to judicially enforced specific performance if for any reason the necessary documents are not executed and delivered, and waiver of any stay on appeal from a judicial order compelling any of those acts.
8.  Effective Date of New Rights . Regardless of the actual dates on which the stock is transferred, the debt is extinguished, and the new promissory note is issued as referenced above in Sections 5 and 6 , and regardless of whether those acts occur voluntarily or by judicial compulsion, each of those acts shall be deemed to have occurred as of the effective date of this Final Settlement Agreement.
9.  Tax Consequences . No Party has made any representations, warranties or agreements regarding the tax consequences, if any, of the terms of or acts contemplated by this Final Settlement Agreement. Each of the Parties agrees that it/he/she is solely and fully responsible for any such tax consequences to it/him/her, and further agrees to indemnify the other side and hold it harmless from any claim resulting from its/his/her failure to discharge any tax-related obligations arising out of or related to this Final Settlement Agreement.
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CONFIDENTIAL
10.  No Disparagement . Each of the Parties agree not to disparage (directly or indirectly, orally or in writing) the other Parties or any of their affiliates, and agree to refrain from making any public statements about the other Parties or any of their affiliates, which would serve to reflect unfavorably upon the image or reputation of such Party.
Releases
11.  Mutual General Releases . Excepting only as to rights and obligations expressly set forth in this Final Settlement Agreement, the ASC Parties on the one hand (and any person who may claim through them), and the Lifeline Parties on the other (and any person who may claim through them), each hereby waives and releases the other side (and their respective parent companies, subsidiaries, affiliates, and sister entities, and their respective shareholders, partners, members, managers, directors, officers, and employees, and their respective attorneys, insurers, agents, representatives, predecessors, successors and assigns), from every right, obligation, action, suit, liability, charge or claim (of the broadest possible description), whether known or unknown, suspected or unsuspected, that any of the ASC Parties may at any time otherwise have against any of the Lifeline Parties, and vice versa, arising from acts, events or circumstances occurring on or before the effective date of this Final Settlement Agreement, including without limitation any right, obligation or claim which arises from or is related to any actual or alleged promissory notes, debt, agreements relating to stock, other contracts, communications, promises, discussions, negotiations, fraud, misrepresentation, breach of fiduciary duty, or other acts or omissions as between ASC and Lifeline. The release given herein excludes for purposes hereof the Final Settlement Agreement. The persons released by the ASC Parties are referred to as the “Lifeline Releasees”. The persons released by the Lifeline Parties are referred to as the “ASC Releasees”.
12.  Waiver of Cal. Civ. Code § 1542 . Each of the Parties represents, warrants and agrees that the releases provided in this Final Settlement Agreement extend to all rights, obligations and claims of every nature and kind as further described above, even if unknown or unsuspected, and expressly waives and relinquishes all rights under California Civil Code §1542 (or similar law of any jurisdiction), which reads as follows:
“A general release does not extend to claims which the creditor does not know or suspect to exist in his favor at the time of executing the release, which if known by him must have materially affected his settlement with the debtor.”
13.  No Other Claims . Each of the ASC Parties and the Lifeline Parties represents and warrants to the other side that it/he/she (a) has not assigned or transferred any claims against the Lifeline Releasees or ASC Releasees, as applicable; and (b) has not filed or otherwise asserted any claims against any of the Lifeline Releasees or ASC Releasees, respectively, with any state, federal, or local agency, court or other tribunal, and warrants and agrees that, except to the extent such an agreement would be prohibited by law, it/he/she will not do so at any time hereafter based on any acts, events or circumstances occurring on or before the effective date of this Final Settlement Agreement, and that, if any agency, court or other tribunal assumes jurisdiction of any such claim on behalf of any of the ASC Parties or the Lifeline Parties, that Party shall direct that agency, court or tribunal to withdraw or dismiss the matter with prejudice.
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CONFIDENTIAL
General Terms
14.  Titles Not Substantive . The titles and headings herein are for ease of reference only and shall not be considered in interpreting this Final Settlement Agreement.
15.  Heirs and Assigns . The rights and obligations of the Parties hereunder shall bind and benefit their respective successors, administrators, spouses, heirs and assigns.
16.  Severability . If any provision of this Final Settlement Agreement is held invalid or contrary to law by a court or other tribunal of competent jurisdiction, the invalidity shall not affect other provisions which can be given their intended effect without the invalid provision, and to this end the provisions of this Final Settlement Agreement are severable.
17.  Integration and Modification . This instrument supersedes all prior discussions and agreements and contains all representations, warranties and agreements between the Parties relating to the rights herein granted and the obligations herein assumed or released. The Parties represent, warrant and agree that in executing this Final Settlement Agreement, they do not rely and have not relied upon any representation, warranty, or agreement made by any of the Parties, other than those representations, warranties and agreements which are expressly stated in this Agreement. The Parties agree that any alleged representations, warranties or agreements not expressly set forth herein were not material to any Party’s decision to enter into this Final Settlement Agreement. This Final Settlement Agreement can be modified only by a writing signed by the Party to be charged.
18.  Waivers . A Party’s waiver or failure to exercise any right under this Final Settlement Agreement shall not be construed to waive, support a finding of estoppel with respect to, or otherwise affect that Party’s assertion of any right in the future.
19.  Jurisdiction and Venue . This Final Settlement Agreement is entered into and shall be performed in the County of Los Angeles, State of California, where both ASC and Lifeline have their headquarters. Each Party consents to the exclusive jurisdiction of California in connection with any claim arising out of or related to this Final Settlement Agreement, and any such claim shall be submitted to the exclusive jurisdiction of the Los Angeles Superior Court. The construction and interpretation of this Final Settlement Agreement shall be governed by the laws of California applicable to contracts made and wholly to be performed in California.
20.  Attorneys’ Fees . In the event of a dispute arising out of or related to this Final Settlement Agreement which reasonably leads to litigation or other dispute-resolution procedure in any tribunal or forum whatsoever, the prevailing Party shall be entitled to an award of attorneys’ fees and expenses (not limited to taxable costs) incurred in connection therewith, including without limitation those incurred in connection with obtaining, enforcing and/or collecting on any award or judgment related to such a dispute or this Final Settlement Agreement.
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CONFIDENTIAL
21.  Negotiation and Advice of Counsel . Each Party acknowledges that it/he/she has had a full opportunity both to negotiate the terms of this Final Settlement Agreement and to obtain legal advice from an attorney of its/his/her choosing regarding the terms of this Final Settlement Agreement, the Parties’ rights and obligations hereunder, and the advisability of entering into this Final Settlement Agreement. Each Party represents that it/he/she has either knowingly decided to execute this Final Settlement Agreement based on advice of counsel or has knowingly decided to waive the right to counsel and execute this Final Settlement Agreement without such advice. This Final Settlement Agreement shall be deemed to have been prepared jointly by the Parties, and the usual rule that the provisions of a document are to be construed against the drafter shall not apply.
22.  Authority to Sign . The person signing below on behalf of each of the Parties, and each of the Parties, represents and warrants that the signing person has the authority to execute this Final Settlement Agreement on behalf of said Party, and that it is not necessary for any other Party to inquire further into the validity of execution or authority to execute. Each Party further represents and warrants that it/he/she is the sole owner of every right, obligation and claim released by it/him/her in this Agreement, and that it/he/she has not assigned, transferred or encumbered all or any part of any such right, obligation or claim.
23.  Multiple Counterparts . This Final Settlement Agreement may be executed in multiple counterparts, each of which shall be deemed an original, but all of which together shall constitute one and the same instrument. Faxed or scanned signatures shall be deemed valid as if they were inked originals.
(Signature Pages to Follow)
Lifeline/ASC Final Settlement Agreement — Page 5 of 9

 

 


 

Wherefore, the Parties affix their authorized signatures hereto:
                 
AMERICAN STEM CELL CORPORATION        
 
               
By:   /S/ KENNETH SWAISLAND       /S/ ANDREW SCHWAB
             
    Kenneth Swaisland, CEO       Andrew Schwab, Secretary
 
               
LIFELINE CELL TECHNOLOGIES, LLC        
 
               
By:   /S/ KENNETH C. ALDRICH       /S/ WILLIAM B. ADAMS
             
    Kenneth C. Aldrich,       William B. Adams,
    Managing Member       Managing Member
 
               
/S/ KEN SORENSEN       /S/ KENNETH SWAISLAND
         
Ken Sorensen, Individually       Kenneth Swaisland, Individually
 
               
/S/ MILTON DATSOPOULOS       /S/ MICHAEL MCLAIN
         
Milton Datsopoulos, Individually       Michael McClain, Individually
 
               
/S/ JEFFREY JANUS       /S/ WILLIAM B. ADAMS
         
Jeffrey Janus, Individually       William B. Adams, Individually
 
               
/S/ KENNETH C. ALDRICH            
             
Kenneth C. Aldrich, Individually            
                 
ARRAY CAPITAL       CATALYTIX LDC
 
               
By:
  /S/ KEN SORENSEN       By:   /S/ KEN SORENSEN
 
               
Title:
          Title:    
 
 
 
         
 
 
 
               
CATALYTIX LIFE SCIENCES HEDGE       AVION HOLDINGS, INC.
 
               
By:
  /S/ KEN SORENSEN       By:   /S/KENNETH SWAISLAND
 
               
Title:
          Title:    
 
               
 
(Signature Page to Lifeline/ASC Final Settlement Agreement)
Lifeline/ASC Final Settlement Agreement — Page 6 of 9

 

 

 

Exhibit 10.8
PROMISSORY NOTE
     
$500,000.00
  Los Angeles, California
 
  June 30, 2006
FOR VALUE RECEIVED, the undersigned (“Maker”) promises to pay to American Stem Cell Corporation (“Payee”), or order, at 11300 West Olympic Blvd., Suite 800, Attn: Christopher Dieterich, or at any other place that Payee designates by notice to Maker, in United States Dollars, the sum of Five Hundred Thousand dollars ($500.000.00) on the following terms.
1. Payments .
(a)  Principal . Subject to the provisions of Section 2, the entire principal amount hereof shall be payable in full on June 30, 2007 (the “Maturity Date”). No interest shall accrue prior to maturity.
(b)  Prepayments . This Note may be prepaid in whole or in part, at any time prior to maturity without consent of the holder without any penalty or premium.
2. Early Repayment.
(a)  Upon Closing of a Qualifying Financing . Upon the consummation of the Payee’s placement of $2,000,000 or more in equity financing prior to the Maturity Date, Maker shall make partial early repayment of this Note in an amount equal to 10% of such financing up to the amount of $500,000; provided that if such financing is part of a larger financing with multiple closings, no payment hereunder shall be due until the final closing of such financing or the Maturity Date, whichever comes first.
3. Default .
(a)  Events of Default . Maker shall be in default of this Note on the occurrence of any of the following:
(i)  Payments . Failure of Maker to make any payment under this Note within three days of the due date.
(ii) Bankruptcy .
(A) The filing by Maker of a voluntary petition in bankruptcy, a petition for reorganization, arrangement or other relief under the United States Bankruptcy Act, or a voluntary petition for the appointment of a receiver or comparable relief from creditors under the laws of any state, or the making by Maker of an assignment of all or substantially all of its assets for the benefit of creditors.
(B) The adjudication of Maker as a bankrupt or insolvent, the appointment of a receiver of all or substantially all of Maker’s assets, or the entry of an order of the reorganization of Maker under the United States Bankruptcy Act, if such adjudication, appointment or order is made on a petition filed against Maker and is not, within 90 days after it is made, vacated or stayed on appeal or otherwise, or if Maker consents to the appointment, order or petition.

 

 


 

(b)  Acceleration on Default . When Maker is in default, the entire unpaid principal balance of this Note shall become immediately due and payable at the election of Payee, upon the notification of such election to Maker and the expiration of any applicable cure period, and interest shall accrue thereafter on the unpaid balance at the rate of 8% per annum.
4.  Collection Costs . On any default by Maker, Payee shall be entitled to recover from Maker all costs of collection and enforcement, including, without limitation, reasonable attorneys’ fees.
5.  Condition of Payment . Payment under this Note is conditioned upon the absence of breach by the ASC Parties under the Final Settlement Agreement, dated as of June 30, 2006, between the ASC Parties and the Lifeline Parties (the “Settlement Agreement”), the terms of which are hereby incorporated by reference. Payments to be made under this Note may be offset against any amounts owed to Maker under the Settlement Agreement at the election of Maker.
6.  Remedies Cumulative . The rights and remedies of Payee under this Note are cumulative and may be pursued singly, successively or together against Maker and any funds or security held by Payee.
7.  Governing Law . This Note and the rights and obligations of the parties hereto shall be governed by and construed and enforced in accordance with the laws of the State of California applicable to agreements executed and to be performed in the State of California, irrespective of its choice-of-law provisions.
8.  Notices . Unless otherwise expressly stated in this Note, all notices given hereunder shall be in writing and shall be served personally, or be mailed in U.S. mail, first class certified, registered or Express Mail postage prepaid, and a return receipt requested, or be deposited with a nationally recognized commercial courier service with next-day delivery charges prepaid. Notices may also effectively be given by transmittal over facsimile machine or other electronic transmitting device if the party to whom the notice is being sent has a receiving device in its office and a copy of the notice is also served personally or in the same manner required for a mailed notice or a notice deposited with a commercial courier service. Notices shall be deemed received at the earlier of actual receipt or three days following deposit, in the manner required above, in U.S. mail or with a commercial courier service. Notices shall be directed to the following addresses:
         
 
  Payee:   American Stem Cell Corporation
 
      C/O Christopher Dieterich
 
      11300 W. Olympic Blvd. Suite 800
 
      Los Angeles, CA 90064

 

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  Maker:   Lifeline Cell Technology, LLC
 
      157 Surfview Drive
 
      Pacific Palisades, CA 90272
Either party to this Note may change its address for notice purposes by giving notice to the other parties in accordance with this Section 7, provided that the address change shall not be effective until three days after notice of the change.
9.  Severability . If any part of this Note is determined to be illegal or unenforceable, all other parts shall remain in effect.
10.  Successors and Assigns . This Note shall inure to the benefit of and bind the parties hereto and their respective successors, assigns, heirs, executors and administrators.
IN WITNESS WHEREOF, Maker has signed and delivered this Note effective as of the date first set forth above.
Lifeline Cell Technology, LLC
By:/S/ KENNETH C. ALDRICH
Accecpted: American Stem Cell Corporation
By:           /S/KENNETH SWAISLAND

 

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Exhibit 10.9

FIRST AMENDMENT TO EXCLUSIVE LICENSE AGREEMENT (ACT IP)
This First Amendment to Exclusive License Agreement (ACT IP) (“First Amendment”) is made and entered into as of this 1ST day of August, 2005 (the “Amendment Effective Date”), by and between Advanced Cell, Inc. (formerly known as Advanced Cell Technology, Inc.), a Delaware corporation with offices located at 381 Plantation Street, Worcester, Massachusetts 01605 (“LICENSOR”), and Lifeline Cell Technology, LLC (formerly known as PacGen Cellco, LLC), a California limited liability company with offices located at 157 Surfview Drive, Pacific Palisades, CA 90272 (“LICENSEE”) (LICENSOR and LICENSEE sometimes hereinafter referred to individually as a “Party” and collectively as the “Parties”).
WHEREAS, the Parties previously entered into an Exclusive License Agreement (ACT IP), dated May 14, 2004 (the “License Agreement”), which grants LICENSEE defined rights to use certain intellectual property controlled by LICENSOR; and
WHEREAS, the Parties also entered into that certain Agreement to Amend ACT/Cellco License Agreements dated September 7, 2004 (the “Agreement to Amend”), which contemplates that the Parties will amend the License Agreement in certain respects; and
WHEREAS, the Parties have agreed to amend the License Agreement as provided herein;
NOW, THEREFORE, in consideration of the premises and terms of this First Amendment, and in consideration of the payment to LICENSOR by LICENSEE of $84,375, the receipt of which is hereby acknowledged by LICENSOR, the Parties agree to amend the License Agreement as follows:
1. Section 1.2 is deleted in its entirety and replaced with the following:
  1.2   “FIELD” shall mean (1) the research, development, manufacture and selling to third parties of human and non-human animal cells for commercial research use, including small molecule and other drug testing and basic research and (2) the manufacture and selling of human cells for therapeutic and diagnostic use in the treatment of human (a) diabetes, (b) liver diseases and (c) retinal diseases and retinal degenerative diseases; but FIELD shall exclude applications involving the use of cells in the treatment of tumors where the primary use of the cells is the destruction or reduction of tumors and does not involve regeneration of tissue or organ function.
2. Section 1.3 is deleted in its entirety and replaced with the following:
  1.3   “KNOW-HOW” means all compositions of matter, techniques and data and other know-how and technical inventions (whether or not patentable), improvements and developments, practices, methods, concepts, trade secrets, documents, computer data, computer code, apparatus, clinical and regulatory strategies, test data, analytical and quality control data, formulation, manufacturing, patent data or descriptions, development information, drawings, specifications, designs, plans, proposals and technical data and manuals and all other proprietary

 

 


 

      information that is owned or controlled by LICENSOR as of the Effective Date that relates to cloning technology or to any of the subject matter described in or claimed by the PATENT RIGHTS and is relevant to the FIELD. By way of illustration, but not in limitation, KNOW-HOW shall include commercial rights in the FIELD to any existing or potential research products, including reagents, developed by LICENSOR in the course of its in-house research as more fully described in Section 15.3 of this Agreement. An example of this is the proprietary culture medium developed by LICENSOR in the course of the development of LICENSOR’s proprietary ooplasmic transfer technology.
3. Section 1.9 is amended by deleting the text in Section 1.9 in its entirety and replacing it with the following: “Intentionally omitted”.
4. Section 2.5 is deleted in its entirety and replaced with the following:
LICENSEE acknowledges and agrees that notwithstanding anything to the contrary in this Agreement, LICENSOR may: (i) practice the LICENSED TECHNOLOGY and develop and manufacture LICENSED PRODUCTS within the FIELD for research purposes, provided that LICENSOR may not market or sell LICENSED PRODUCTS in the FIELD to third parties in contravention of LICENSEE’S exclusive rights hereunder; (ii) distribute or otherwise transfer cells or cell lines or other reagents to collaborators for research purposes, and commercialize the results of such research (other than media and other reagents produced for sale to the commercial research market) outside the FIELD in connection with the research, development, manufacture or sale of therapeutic products that are not in contravention of LICENSEE’S exclusive rights hereunder; and (iii) distribute or otherwise transfer cells or cell lines to collaborators for the purposes of researching, developing and commercializing cell based therapeutics for purposes other than those exclusively licensed to LICENSEE hereunder.
By way of illustration of subparagraph (ii) of Section 2.5 hereof, should LICENSOR partner with a biopharmaceutical company in order to produce skin cells for human therapeutic use, and in the process of basic research, preclinical, or clinical development find it necessary or useful to transfer cell lines or other reagents to that partner to facilitate the development of such dermatological product, such transfer, provided that the transferred material is not sold or marketed to such biopharmaceutical company for monetary compensation, shall be considered outside of the FIELD.
LICENSOR may make LICENSED PRODUCTS available to its collaborators. In the event LICENSOR requests that LICENSEE deliver to LICENSOR LICENSED PRODUCTS in the FIELD for use in connection with the purposes described in the above paragraph, LICENSEE shall make such LICENSED PRODUCTS available to LICENSOR on commercially reasonable terms. LICENSOR may make

 

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LICENSED PRODUCTS in the FIELD, whether developed and manufactured by LICENSOR or obtained from LICENSEE, available to its collaborators, provided that LICENSOR enters into a license with any such collaborator that expressly prohibits the collaborator from commercializing the LICENSED TECHNOLOGY in the FIELD or using the LICENSED PRODUCTS in the FIELD for any purpose other than in connection with the collaboration with LICENSOR for the purposes described above. LICENSOR shall provide LICENSEE with a copy of any such license entered into with a collaborator prior to delivering any LICENSED PRODUCTS in the FIELD; provided , however , that LICENSOR may redact from such license agreements any financial terms LICENSOR considers proprietary or confidential and not relevant to LICENSEE’S exclusive rights hereunder, and provided further that any such licenses provided to LICENSEE shall be considered and treated as Confidential Information under Article 10 of this Agreement. Any license by LICENSOR to a collaborator hereunder shall specifically provide that any intellectual property developed under such collaboration shall be treated as if developed by LICENSOR for purposes of determining if it is subject to any of the provisions of this Agreement.
5. Section 2.6 is deleted in its entirety.
6. Section 4.3 is amended in part by deleting the text (including numbers) after the words “and the following minimum amounts:” and replacing such text with the following:
         
 
  (i)   At 12 months, $15,000
 
  (ii)   At 24 months, $37,500
 
  (iii)   At 36 months, $60,625
 
  (iv)   Annually thereafter, $75,000
7. Section 15.3 is amended by deleting the words “including any rights acquired under Section 15.18 hereof,”.
8. Section 15.18 is amended by deleting the text in said Section in its entirety and replacing it with the following:
  15.18   To support the grant of rights hereunder with respect to retinal disease, LICENSOR shall provide the services of Robert Lanza, M.D., his assistants and the use of such lab space and equipment as they may need that LICENSOR can reasonable supply, understanding that Dr. Lanza, his assistants are the full-time employees of LICENSOR and the equipment will be primarily used for LICENSOR research. Such assistance will be for a period of the earlier of one year from the date of this Amendment or until:
(a) the completion of preliminary animal studies to assess safety and efficacy of applying cells for the treatment of retinitis pigmentosa and/or macular degeneration (including any contracts or rights already established for initial animal studies);

 

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(b) completion and submission of a scientific paper to a peer-reviewed journal co-authored by LICENSOR and LICENSEE scientists presenting animal data and analysis (subject to the pre-approval of both parties prior to publication);
(c) completion of consultations with the FDA to assess the suitability of animal data gathered to initiate the paperwork for early stage human clinical trials;
(d) initiation of process of filing the paperwork for early stage human trials.
A committee composed of Michael West, Ph.D., Robert Lanza, M.D. and Irina Klimanskaya, Ph.D., as the LICENSOR representatives, and Jeffrey Janus and two additional representatives from LICENSEE that LICENSEE will promptly identify to LICENSOR in writing (the “Committee”), will meet periodically during the six-month period commencing on the Amendment Effective Date to discuss completion of the above-identified tasks.
The LICENSEE Committee representatives may consult informally with the LICENSOR Committee representatives, both in person and by telephone, regarding issues of mutual interest identified by the Committee. The Committee shall meet during such six-month period at the facilities of LICENSOR or LICENSEE as shall be mutually determined; the time and place of such meetings, and the agenda for such meetings, shall be determined by mutual agreement. It is contemplated by the Parties that the Committee will meet three times during the six-month period. Either party may replace its representatives at any time, upon written notice and mutual agreement of the parties.
The foregoing notwithstanding, if LICENSOR is unable or unwilling to complete the tasks outlined in this Section 15.18 above, LICENSEE shall have the right to manage and carry the work forward so long as LICENSEE provides funding for the project, in which case any intellectual property that is developed under LICENSEE’s management and funding shall accrue to LICENSEE, and LICENSEE shall be entitled to treat as prepayment of future licensing requirements under this and other license agreements between LICENSOR and LICENSEE the actual costs incurred by LICENSEE in completing subsections (a) through (d) above; provided , however , that LICENSEE shall not be entitled to treat any such costs as prepayment of future licensing requirements under this and other license agreements between LICENSOR and LICENSEE if LICENSOR transfers to LICENSEE the technological protocols, techniques and training necessary for LICENSEE to replicate LICENSOR’S generation of retinal cells from stem cells. LICENSEE and LICENSOR agree that the transfer to LICENSEE of the technological protocols, techniques and training necessary for LICENSEE to replicate LICENSOR’S generation of retinal cells from stem cells shall be complete when LICENSOR provides LICENSEE with written copies of such protocols and techniques and two weeks of additional lab training at the Worcester facility by two qualified technicians within six months after the Amendment Effective Date.

 

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9. The Agreement is amended by replacing all references to the word “Product” with the term “Licensed Product”.
10. This First Amendment shall be governed by and construed in accordance with the laws of the State of Delaware, without regard to principles of conflicts of law thereof, and shall be binding upon and inure to the benefit of the Parties and their respective successors and assigns.
11. The Parties agree that the Agreement to Amend is terminated by mutual agreement and that all of its provisions are superseded in their entirety by this First Amendment. The License Agreement, as amended hereby, contains the entire agreement of the Parties hereto and thereto with respect to the matters discussed herein and therein. This First Amendment may not be modified except in writing signed by the Parties.
12. Except to the extent specifically amended hereby, the terms and provisions of the License Agreement are hereby ratified and affirmed in all respects and continue in full force and effect.
IN WITNESS WHEREOF, this First Amendment has been executed by duly authorized representatives of the Parties as of the Amendment Effective Date.
ADVANCED CELL, INC.
By: /S/ WILLIAM M. CALDWELL, IV
Printed Name: William M. Caldwell, IV
Title: Chief Executive Officer
LIFELINE CELL TECHNOLOGY, LLC
By: /S/ KENNETH ALDRICH
Printed Name: Kenneth Aldrich
Title: Managing Member

 

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Exhibit 10.10

FIRST AMENDMENT TO EXCLUSIVE LICENSE AGREEMENT (UMass IP)
This First Amendment to Exclusive License Agreement (UMass IP) (“First Amendment”) is made and entered into as of this 1ST day of August, 2005 (the “Amendment Effective Date”), by and between Advanced Cell, Inc. (formerly known as Advanced Cell Technology, Inc.), a Delaware corporation with offices located at 381 Plantation Street, Worcester, Massachusetts 01605 (“LICENSOR”), and Lifeline Cell Technology, LLC (formerly known as PacGen Cellco, LLC), a California limited liability company with offices located at 157 Surfview Drive, Pacific Palisades, CA 90272 (“LICENSEE”) (LICENSOR and LICENSEE sometimes hereinafter referred to individually as a “Party” and collectively as the “Parties”).
WHEREAS, the Parties previously entered into an Exclusive License Agreement (UMass IP), dated May 14, 2004 (the “License Agreement”), which grants LICENSEE defined rights to use certain intellectual property controlled by LICENSOR; and
WHEREAS, the Parties also entered into that certain Agreement to Amend ACT/Cellco License Agreements dated September 7, 2004 (the “Agreement to Amend”), which contemplates that the Parties will amend the License Agreement in certain respects; and
WHEREAS, the Parties have agreed to amend the License Agreement as provided herein;
NOW, THEREFORE, in consideration of the premises and terms of this First Amendment, and in consideration of the payment to LICENSOR by LICENSEE of $56,250, the receipt of which is hereby acknowledged by LICENSOR, the Parties agree to amend the License Agreement as follows:
1. Section 1.3 is deleted in its entirety and replaced with the following:
  1.3   “FIELD” shall mean (1) the research, development, manufacture and selling to third parties of human and non-human animal cells and ACT ANIMAL CELL LINES for commercial research use, including small molecule and other drug testing and basic research, (2) the manufacture and selling of human cells for therapeutic and diagnostic use in the treatment of human (a) diabetes, (b) liver diseases and (c) retinal diseases and retinal degenerative diseases, and (3) the use of ACT ANIMAL CELL LINES in the process of manufacturing and selling human cells for therapeutic and diagnostic use in the treatment of human (a) diabetes, (b) liver diseases and (c) retinal diseases and retinal degenerative diseases, but where the final marketed product does not include ACT ANIMAL CELL LINES ( i.e . does not include the field of xenotransplantation); but FIELD shall exclude applications involving the use of cells in the treatment of tumors where the primary use of the cells is the destruction or reduction of tumors and does not involve regeneration of tissue or organ function.
2. Section 1.4 is deleted in its entirety and replaced with the following:
  1.4   “KNOW-HOW” means all compositions of matter, techniques and data and other know-how and technical inventions (whether or not patentable), improvements

 

 


 

      and developments, practices, methods, concepts, trade secrets, documents, computer data, computer code, apparatus, clinical and regulatory strategies, test data, analytical and quality control data, formulation, manufacturing, patent data or descriptions, development information, drawings, specifications, designs, plans, proposals and technical data and manuals and all other proprietary information that is owned or controlled by LICENSOR as of the Effective Date that relates to cloning technology or to any of the subject matter described in or claimed by the PATENT RIGHTS and is relevant to the FIELD. By way of illustration, but not in limitation, KNOW-HOW shall include commercial rights in the FIELD to any existing or potential research products, including reagents, developed by LICENSOR in the course of its in-house research as more fully described in Section 15.3 of this Agreement. An example of this is the proprietary culture medium developed by LICENSOR in the course of the development of LICENSOR’s proprietary ooplasmic transfer technology.
3. Section 1.10 is amended by deleting the text in Section 1.10 in its entirety and replacing it with the following: “Intentionally omitted”.
4. Section 2.6 is deleted in its entirety and replaced with the following:
LICENSEE acknowledges and agrees that notwithstanding anything to the contrary in this Agreement, LICENSOR may: (i) practice the LICENSED TECHNOLOGY and develop and manufacture LICENSED PRODUCTS within the FIELD for research purposes, provided that LICENSOR may not market or sell LICENSED PRODUCTS in the FIELD to third parties in contravention of LICENSEE’S exclusive rights hereunder; (ii) distribute or otherwise transfer cells or cell lines or other reagents to collaborators for research purposes, and commercialize the results of such research (other than media and other reagents produced for sale to the commercial research market) outside the FIELD in connection with the research, development, manufacture or sale of therapeutic products that are not in contravention of LICENSEE’S exclusive rights hereunder; and (iii) distribute or otherwise transfer cells or cell lines to collaborators for the purposes of researching, developing and commercializing cell based therapeutics for purposes other than those exclusively licensed to LICENSEE hereunder.
By way of illustration of subparagraph (ii) of Section 2.6 hereof, should LICENSOR partner with a biopharmaceutical company in order to produce skin cells for human therapeutic use, and in the process of basic research, preclinical, or clinical development find it necessary or useful to transfer cell lines or other reagents to that partner to facilitate the development of such dermatological product, such transfer, provided that the transferred material is not sold or marketed to such biopharmaceutical company for monetary compensation, shall be considered outside of the FIELD.

 

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LICENSOR may make LICENSED PRODUCTS available to its collaborators. In the event LICENSOR requests that LICENSEE deliver to LICENSOR LICENSED PRODUCTS in the FIELD for use in connection with the purposes described in the above paragraph, LICENSEE shall make such LICENSED PRODUCTS available to LICENSOR on commercially reasonable terms. LICENSOR may make LICENSED PRODUCTS in the FIELD, whether developed and manufactured by LICENSOR or obtained from LICENSEE, available to its collaborators, provided that LICENSOR enters into a license with any such collaborator that expressly prohibits the collaborator from commercializing the LICENSED TECHNOLOGY in the FIELD or using the LICENSED PRODUCTS in the FIELD for any purpose other than in connection with the collaboration with LICENSOR for the purposes described above. LICENSOR shall provide LICENSEE with a copy of any such license entered into with a collaborator prior to delivering any LICENSED PRODUCTS in the FIELD; provided , however , that LICENSOR may redact from such license agreements any financial terms LICENSOR considers proprietary or confidential and not relevant to LICENSEE’S exclusive rights hereunder, and provided further that any such licenses provided to LICENSEE shall be considered and treated as Confidential Information under Article 10 of this Agreement. Any license by LICENSOR to a collaborator hereunder shall specifically provide that any intellectual property developed under such collaboration shall be treated as if developed by LICENSOR for purposes of determining if it is subject to any of the provisions of this Agreement.
5. Section 4.3 is amended in part by deleting the text (including numbers) after the words “and the following minimum amounts:” and replacing such text with the following:
         
 
  (i)   At 12 months, $15,000
 
  (ii)   At 24 months, $30,000
 
  (iii)   At 36 months, $45,000
 
  (iv)   Annually thereafter, $60,000
6. Section 15.3 is amended by deleting the words “including any rights acquired under Section 15.18 hereof,”.
7. Section 15.18 is amended by deleting the text in said Section in its entirety and replacing it with the following:
  15.18   To support the grant of rights hereunder with respect to retinal disease, LICENSOR shall provide the services of Robert Lanza, M.D., his assistants and the use of such lab space and equipment as they may need that LICENSOR can reasonable supply, understanding that Dr. Lanza, his assistants are the full-time employees of LICENSOR and the equipment will be primarily used for LICENSOR research. Such assistance will be for a period of the earlier of one year from the date of this Amendment or until:

 

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(a) the completion of preliminary animal studies to assess safety and efficacy of applying cells for the treatment of retinitis pigmentosa and/or macular degeneration (including any contracts or rights already established for initial animal studies);
(b) completion and submission of a scientific paper to a peer-reviewed journal co-authored by LICENSOR and LICENSEE scientists presenting animal data and analysis (subject to the pre-approval of both parties prior to publication);
(c) completion of consultations with the FDA to assess the suitability of animal data gathered to initiate the paperwork for early stage human clinical trials;
(d) initiation of process of filing the paperwork for early stage human trials.
A committee composed of Michael West, Ph.D., Robert Lanza, M.D. and Irina Klimanskaya, Ph.D., as the LICENSOR representatives, and Jeffrey Janus and two additional representatives from LICENSEE that LICENSEE will promptly identify to LICENSOR in writing (the “Committee”), will meet periodically during the six-month period commencing on the Amendment Effective Date to discuss completion of the above-identified tasks.
The LICENSEE Committee representatives may consult informally with the LICENSOR Committee representatives, both in person and by telephone, regarding issues of mutual interest identified by the Committee. The Committee shall meet during such six-month period at the facilities of LICENSOR or LICENSEE as shall be mutually determined; the time and place of such meetings, and the agenda for such meetings, shall be determined by mutual agreement. It is contemplated by the Parties that the Committee will meet three times during the six-month period. Either party may replace its representatives at any time, upon written notice and mutual agreement of the parties.
The foregoing notwithstanding, if LICENSOR is unable or unwilling to complete the tasks outlined in this Section 15.18 above, LICENSEE shall have the right to manage and carry the work forward so long as LICENSEE provides funding for the project, in which case any intellectual property that is developed under LICENSEE’s management and funding shall accrue to LICENSEE, and LICENSEE shall be entitled to treat as prepayment of future licensing requirements under this and other license agreements between LICENSOR and LICENSEE the actual costs incurred by LICENSEE in completing subsections (a) through (d) above; provided , however , that LICENSEE shall not be entitled to treat any such costs as prepayment of future licensing requirements under this and other license agreements between LICENSOR and LICENSEE if LICENSOR transfers to LICENSEE the technological protocols, techniques and training necessary for LICENSEE to replicate LICENSOR’S generation of retinal cells

 

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from stem cells. LICENSEE and LICENSOR agree that the transfer to LICENSEE of the technological protocols, techniques and training necessary for LICENSEE to replicate LICENSOR’S generation of retinal cells from stem cells shall be complete when LICENSOR provides LICENSEE with written copies of such protocols and techniques and two weeks of additional lab training at the Worcester facility by two qualified technicians within six months after the Amendment Effective Date.
8. The Agreement is amended by replacing all references to the word “Product” with the term “Licensed Product”.
9. This First Amendment shall be governed by and construed in accordance with the laws of the State of Delaware, without regard to principles of conflicts of law thereof, and shall be binding upon and inure to the benefit of the Parties and their respective successors and assigns.
10. The Parties agree that the Agreement to Amend is terminated by mutual agreement and that all of its provisions are superseded in their entirety by this First Amendment. The License Agreement, as amended hereby, contains the entire agreement of the Parties hereto and thereto with respect to the matters discussed herein and therein. This First Amendment may not be modified except in writing signed by the Parties.
11. Except to the extent specifically amended hereby, the terms and provisions of the License Agreement are hereby ratified and affirmed in all respects and continue in full force and effect.
IN WITNESS WHEREOF, this First Amendment has been executed by duly authorized representatives of the Parties as of the Amendment Effective Date.
ADVANCED CELL, INC.
By: /S/William M. Caldwell, IV
Printed Name: William M. Caldwell, IV
Title: Chief Executive Officer
LIFELINE CELL TECHNOLOGY, LLC
By: /S/ KENNETH ALDRICH
Printed Name: Kenneth Aldrich
Title: Managing Member

 

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Exhibit 10.11

FIRST AMENDMENT TO EXCLUSIVE LICENSE AGREEMENT (Infigen IP)
This First Amendment to Exclusive License Agreement (Infigen IP) (“First Amendment”) is made and entered into as of this 1ST day of August, 2005 (the “Amendment Effective Date”), by and between Advanced Cell, Inc. (formerly known as Advanced Cell Technology, Inc.), a Delaware corporation with offices located at 381 Plantation Street, Worcester, Massachusetts 01605 (“LICENSOR”), and Lifeline Cell Technology, LLC (formerly known as PacGen Cellco, LLC), a California limited liability company with offices located at 157 Surfview Drive, Pacific Palisades, CA 90272 (“LICENSEE”) (LICENSOR and LICENSEE sometimes hereinafter referred to individually as a “Party” and collectively as the “Parties”).
WHEREAS, the Parties previously entered into an Exclusive License Agreement (Infigen IP), dated May 14, 2004 (the “License Agreement”), which grants LICENSEE defined rights to use certain intellectual property controlled by LICENSOR; and
WHEREAS, the Parties also entered into that certain Agreement to Amend ACT/Cellco License Agreements dated September 7, 2004 (the “Agreement to Amend”), which contemplates that the Parties will amend the License Agreement in certain respects; and
WHEREAS, the Parties have agreed to amend the License Agreement as provided herein;
NOW, THEREFORE, in consideration of the premises and terms of this First Amendment, and in consideration of the payment to LICENSOR by LICENSEE of $9,375, the receipt of which is hereby acknowledged by LICENSOR, the Parties agree to amend the License Agreement as follows:
1. Section 1.2 is deleted in its entirety and replaced with the following:
  1.2   “FIELD” shall mean the research, development, manufacture and selling to third parties of human cells for cell therapy in the treatment of human (a) diabetes, (b) liver diseases and (c) retinal diseases and retinal degenerative diseases; but FIELD shall exclude applications involving the use of cells in the treatment of tumors where the primary use of the cells is the destruction or reduction of tumors and does not involve regeneration of tissue or organ function.
2. Section 1.3 is deleted in its entirety and replaced with the following:
  1.3   “KNOW-HOW” means all compositions of matter, techniques and data and other know-how and technical inventions (whether or not patentable), improvements and developments, practices, methods, concepts, trade secrets, documents, computer data, computer code, apparatus, clinical and regulatory strategies, test data, analytical and quality control data, formulation, manufacturing, patent data or descriptions, development information, drawings, specifications, designs, plans, proposals and technical data and manuals and all other proprietary information that is owned or controlled by LICENSOR as of the Effective Date that relates to cloning technology or to any of the subject matter described in or claimed by the PATENT RIGHTS and is relevant to the FIELD. By way of

 

 


 

      illustration, but not in limitation, KNOW-HOW shall include commercial rights in the FIELD to any existing or potential research products, including reagents, developed by LICENSOR in the course of its in-house research as more fully described in Section 15.3 of this Agreement. An example of this is the proprietary culture medium developed by LICENSOR in the course of the development of LICENSOR’s proprietary ooplasmic transfer technology.
3. Section 1.9 is amended by deleting the text in Section 1.9 in its entirety and replacing it with the following: “Intentionally omitted”.
4. Section 2.5 is deleted in its entirety and replaced with the following:
LICENSEE acknowledges and agrees that notwithstanding anything to the contrary in this Agreement, LICENSOR may: (i) practice the LICENSED TECHNOLOGY and develop and manufacture LICENSED PRODUCTS within the FIELD for research purposes, provided that LICENSOR may not market or sell LICENSED PRODUCTS in the FIELD to third parties in contravention of LICENSEE’S exclusive rights hereunder; (ii) distribute or otherwise transfer cells or cell lines or other reagents to collaborators for research purposes, and commercialize the results of such research (other than media and other reagents produced for sale to the commercial research market) outside the FIELD in connection with the research, development, manufacture or sale of therapeutic products that are not in contravention of LICENSEE’S exclusive rights hereunder; and (iii) distribute or otherwise transfer cells or cell lines to collaborators for the purposes of researching, developing and commercializing cell based therapeutics for purposes other than those exclusively licensed to LICENSEE hereunder.
By way of illustration of subparagraph (ii) of Section 2.5 hereof, should LICENSOR partner with a biopharmaceutical company in order to produce skin cells for human therapeutic use, and in the process of basic research, preclinical, or clinical development find it necessary or useful to transfer cell lines or other reagents to that partner to facilitate the development of such dermatological product, such transfer, provided that the transferred material is not sold or marketed to such biopharmaceutical company for monetary compensation, shall be considered outside of the FIELD.
LICENSOR may make LICENSED PRODUCTS available to its collaborators. In the event LICENSOR requests that LICENSEE deliver to LICENSOR LICENSED PRODUCTS in the FIELD for use in connection with the purposes described in the above paragraph, LICENSEE shall make such LICENSED PRODUCTS available to LICENSOR on commercially reasonable terms. LICENSOR may make LICENSED PRODUCTS in the FIELD, whether developed and manufactured by LICENSOR or obtained from LICENSEE, available to its collaborators, provided that LICENSOR enters into a license with any

 

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such collaborator that expressly prohibits the collaborator from commercializing the LICENSED TECHNOLOGY in the FIELD or using the LICENSED PRODUCTS in the FIELD for any purpose other than in connection with the collaboration with LICENSOR for the purposes described above. LICENSOR shall provide LICENSEE with a copy of any such license entered into with a collaborator prior to delivering any LICENSED PRODUCTS in the FIELD; provided , however , that LICENSOR may redact from such license agreements any financial terms LICENSOR considers proprietary or confidential and not relevant to LICENSEE’S exclusive rights hereunder, and provided further that any such licenses provided to LICENSEE shall be considered and treated as Confidential Information under Article 10 of this Agreement. Any license by LICENSOR to a collaborator hereunder shall specifically provide that any intellectual property developed under such collaboration shall be treated as if developed by LICENSOR for purposes of determining if it is subject to any of the provisions of this Agreement.
5. Section 2.6 is deleted in its entirety.
6. Section 4.3 is amended in part by deleting the text (including numbers) after the words “and the following minimum amounts:” and replacing such text with the following:
         
 
  (i)   At 12 months, $7,500
 
  (ii)   At 24 months, $7,500
 
  (iii)   At 36 months, $6,875
 
  (iv)   Annually thereafter, $15,000
7. Section 15.3 is amended by deleting the words “including any rights acquired under Section 15.18 hereof,”.
8. Section 15.18 is amended by deleting the text in said Section in its entirety and replacing it with the following:
  15.18   To support the grant of rights hereunder with respect to retinal disease, LICENSOR shall provide the services of Robert Lanza, M.D., his assistants and the use of such lab space and equipment as they may need that LICENSOR can reasonable supply, understanding that Dr. Lanza, his assistants are the full-time employees of LICENSOR and the equipment will be primarily used for LICENSOR research. Such assistance will be for a period of the earlier of one year from the date of this Amendment or until:
(a) the completion of preliminary animal studies to assess safety and efficacy of applying cells for the treatment of retinitis pigmentosa and/or macular degeneration (including any contracts or rights already established for initial animal studies);
(b) completion and submission of a scientific paper to a peer-reviewed journal co-authored by LICENSOR and LICENSEE scientists presenting animal data and analysis (subject to the pre-approval of both parties prior to publication);

 

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(c) completion of consultations with the FDA to assess the suitability of animal data gathered to initiate the paperwork for early stage human clinical trials;
(d) initiation of process of filing the paperwork for early stage human trials.
A committee composed of Michael West, Ph.D., Robert Lanza, M.D. and Irina Klimanskaya, Ph.D., as the LICENSOR representatives, and Jeffrey Janus and two additional representatives from LICENSEE that LICENSEE will promptly identify to LICENSOR in writing (the “Committee”), will meet periodically during the six-month period commencing on the Amendment Effective Date to discuss completion of the above-identified tasks.
The LICENSEE Committee representatives may consult informally with the LICENSOR Committee representatives, both in person and by telephone, regarding issues of mutual interest identified by the Committee. The Committee shall meet during such six-month period at the facilities of LICENSOR or LICENSEE as shall be mutually determined; the time and place of such meetings, and the agenda for such meetings, shall be determined by mutual agreement. It is contemplated by the Parties that the Committee will meet three times during the six-month period. Either party may replace its representatives at any time, upon written notice and mutual agreement of the parties.
The foregoing notwithstanding, if LICENSOR is unable or unwilling to complete the tasks outlined in this Section 15.18 above, LICENSEE shall have the right to manage and carry the work forward so long as LICENSEE provides funding for the project, in which case any intellectual property that is developed under LICENSEE’s management and funding shall accrue to LICENSEE, and LICENSEE shall be entitled to treat as prepayment of future licensing requirements under this and other license agreements between LICENSOR and LICENSEE the actual costs incurred by LICENSEE in completing subsections (a) through (d) above; provided , however , that LICENSEE shall not be entitled to treat any such costs as prepayment of future licensing requirements under this and other license agreements between LICENSOR and LICENSEE if LICENSOR transfers to LICENSEE the technological protocols, techniques and training necessary for LICENSEE to replicate LICENSOR’S generation of retinal cells from stem cells. LICENSEE and LICENSOR agree that the transfer to LICENSEE of the technological protocols, techniques and training necessary for LICENSEE to replicate LICENSOR’S generation of retinal cells from stem cells shall be complete when LICENSOR provides LICENSEE with written copies of such protocols and techniques and two weeks of additional lab training at the Worcester facility by two qualified technicians within six months after the Amendment Effective Date.

 

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9. The Agreement is amended by replacing all references to the word “Product” with the term “Licensed Product”.
10. This First Amendment shall be governed by and construed in accordance with the laws of the State of Delaware, without regard to principles of conflicts of law thereof, and shall be binding upon and inure to the benefit of the Parties and their respective successors and assigns.
11. The Parties agree that the Agreement to Amend is terminated by mutual agreement and that all of its provisions are superseded in their entirety by this First Amendment. The License Agreement, as amended hereby, contains the entire agreement of the Parties hereto and thereto with respect to the matters discussed herein and therein. This First Amendment may not be modified except in writing signed by the Parties.
12. Except to the extent specifically amended hereby, the terms and provisions of the License Agreement are hereby ratified and affirmed in all respects and continue in full force and effect.
IN WITNESS WHEREOF, this First Amendment has been executed by duly authorized representatives of the Parties as of the Amendment Effective Date.
ADVANCED CELL, INC.
By :   /S/ William M. Caldwell, IV
Printed Name: William M. Caldwell, IV
Title: Chief Executive Officer
LIFELINE CELL TECHNOLOGY, LLC
By: /S/ KENNETH ALDRICH
Printed Name: Kenneth Aldrich
Title: Managing Member

 

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Exhibit 10.12

EXCLUSIVE LICENSE AGREEMENT (Infigen IP)
This Exclusive License Agreement (“Agreement”) is made and entered into this 14 th day of May, 2004 (the “Effective Date”), by and between Advanced Cell Technology, Inc., a Delaware corporation with offices located at One Innovation Drive, Worcester, Massachusetts 01605 (“LICENSOR”), and PacGen Cellco, LLC, a California limited liability company with offices located at 157 Surfview Drive, Pacific Palisades, CA 90272 (“LICENSEE”) (LICENSOR and LICENSEE sometimes hereinafter referred to individually as a “Party” and collectively as the “Parties”).
WITNESSETH
WHEREAS, LICENSOR has licensed with sublicenseable interest the PATENT RIGHTS (as defined below) and KNOW-HOW (as defined below); and
WHEREAS, LICENSEE desires to obtain an exclusive worldwide license under LICENSOR’s rights in such technology in the FIELD; and
WHEREAS, LICENSOR is willing to grant such a license to LICENSEE upon the terms and conditions set forth below; and
NOW, THEREFORE, in consideration of the premises and the mutual covenants contained herein, the Parties hereto agree as follows:
ARTICLE 1 — DEFINITIONS
For the purposes of this Agreement, the following words and phrases shall have the following meanings:
1.1 “AFFILIATE” shall mean, with respect to any PERSON, any other PERSON which directly or indirectly controls, is controlled by, or is under common control with, such PERSON. A PERSON shall be regarded as in control of another PERSON if it owns, or directly or indirectly controls, at least fifty percent (50%) of the voting stock or other ownership interest of the other PERSON, or if it directly or indirectly possesses the power to direct or cause the direction of the management and policies of the other PERSON by any means whatsoever.
1.2 “FIELD” shall mean the research, development, manufacture and selling of human cells for cell therapy in the treatment of human (a) diabetes and (b) liver diseases; but FIELD shall exclude applications involving the use of cells in the treatment of tumors where the primary use of the cells is the destruction or reduction of tumors and does not involve regeneration of tissue or organ function.

 

 


 

1.3 “KNOW-HOW” means all compositions of matter, techniques and data and other know-how and technical information including inventions (whether or not patentable), improvements and developments, practices, methods, concepts, trade secrets, documents, computer data, computer code, apparatus, clinical and regulatory strategies, test data, analytical and quality control data, formulation, manufacturing, patent data or descriptions, development information, drawings, specifications, designs, plans, proposals and technical data and manuals and all other proprietary information that is owned or controlled by LICENSOR as of the Effective Date that relates to cloning technology or to any of the subject matter described in or claimed by the PATENT RIGHTS and is relevant to the FIELD. By way of illustration, but not in limitation, KNOW-HOW shall include commercial rights to any existing potential research products, including reagents, developed by LICENSOR in the course of its in-house research. An example of this is the proprietary culture medium developed by LICENSOR in the course of the development of LICENSOR’s proprietary ooplasmic transfer technology.
1.4 “LICENSED PROCESS” means any process or method, the research, development, use, practice, sale, offer for sale, import or export of which cannot be performed without (i) infringing, in whole or in part, one or more VALID CLAIMS of the PATENT RIGHTS, or (ii) using or incorporating some portion of the LICENSED TECHNOLOGY.
1.5 “LICENSED PRODUCT” means any product that cannot be developed, manufactured, used, imported, exported, or sold without (i) infringing, in whole or in part, one or more VALID CLAIMS of the PATENT RIGHTS, or (ii) using or incorporating some portion of the LICENSED TECHNOLOGY.
1.6 “LICENSED SERVICES” means any service, the developing, using, performing, selling, offering for sale, importing or exporting of which by LICENSEE would, but for the licenses granted to LICENSEE in Article 2 of this Agreement, infringe a VALID CLAIM of the PATENT RIGHTS in the country in which any such service is so developed, used, performed, sold, offered for sale, imported or exported by LICENSEE.
1.7 “LICENSED TECHNOLOGY” shall mean, collectively, the licensed PATENT RIGHTS and licensed KNOW-HOW.
1.8 “NET SALES” shall mean the amount billed or invoiced by LICENSEE for the sale or provision of LICENSED PRODUCTS or LICENSED PROCESSES or LICENSED SERVICES less:
  a)   discounts, credits, allowances and rebates allowed;
 
  b)   sales, tariff duties, use and other taxes or governmental charges directly imposed with reference to particular sales;
 
  c)   special packaging, transportation and insurance costs incurred and directly related to the sale of LICENSED PRODUCTS;
 
  d)   amounts allowed or credited on returns; and
 
  e)   uncollected accounts.

 

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1.9 “NEURONAL & HEART FIELD OPTION” means an option described in Section 15.18 hereof for LICENSEE to negotiate terms for license to the LICENSED TECHNOLOGY for the field of diseases related to heart or neurodegenerative diseases
1.10 “PATENT RIGHTS” means (a) the patent applications and patents identified on Exhibit A attached hereto and any patents that issue on said applications and (b) any divisions, continuations, extensions, reissues or reexaminations of any of the patents identified in the foregoing clause (a). The Parties agree that Exhibit A may be revised from time to time after the Effective Date to reflect changes thereto that result from the course of patent prosecution.
1.11 “PERSON” shall mean an individual, corporation, partnership, limited liability company, trust, business trust, association, joint stock company, joint venture, pool, syndicate, sole proprietorship, unincorporated organization, governmental authority or any other form of entity not specifically listed herein.
1.12 “TERM” has the meaning set forth in Section 9.1 .
1.13 “TERRITORY” means the entire world.
1.14 “VALID CLAIM” means a claim of any issued and unexpired patent within the PATENT RIGHTS which has not lapsed, become abandoned or been held permanently revoked, invalid, or unenforceable by a decision of a court or administrative or government authority or agency of competent jurisdiction from which no appeal can be or has been taken within the time allowed for such appeal, or a claim of a pending patent application included within the Licensed PATENT RIGHTS, which claim was filed in good faith and has not been abandoned or finally disallowed without the possibility of appeal or refiling of such application.
Additional terms may be defined throughout this Agreement.
ARTICLE 2 — GRANT
2.1 LICENSOR hereby grants to LICENSEE, and LICENSEE hereby accepts, subject to the terms and conditions hereof, a royalty bearing, exclusive, as to LICENSOR’s rights, license in the TERRITORY in the FIELD and under the LICENSED TECHNOLOGY to (a) research, develop, make, have made, use, sell, offer for sale, import and export LICENSED PRODUCTS, (b) research, develop, use, practice, sell, offer for sale, import and export LICENSED PROCESSES and (c) develop, use, perform, sell, offer for sale, import and export LICENSED SERVICES. By way of example, but not in limitation, LICENSEE shall have the right to use LICENSED TECHNOLOGY within the FIELD for the following purpose: to produce human embryonic stem (ES) cells and to produce from those mammalian embryonic cells, differentiated cells for human cell therapy within the FIELD, and to produce pluripotent cells including ES cells, differentiated human cells for cell therapy within the FIELD.

 

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2.2 LICENSEE shall have the right to contract with third parties to (a) provide LICENSED PRODUCT marketing and distribution services to LICENSEE on behalf of LICENSEE, (b) provide LICENSED SERVICES marketing services to LICENSEE on behalf of LICENSEE or (c) manufacture for LICENSEE LICENSED PRODUCTS for sale by LICENSEE or a third party pursuant to the foregoing clause (a).
2.3 LICENSEE shall not have the right to grant sublicenses.
2.4 Within thirty (30) business days of the Effective Date, LICENSOR shall provide and transfer to LICENSEE, in writing where practicable, all information and data relating to the LICENSED TECHNOLOGY as may be reasonably necessary and requested to allow LICENSEE to exploit the licenses granted hereunder. LICENSOR shall work with LICENSEE in good faith to provide the necessary training for up to a total of 60 days, at LICENSOR’s facilities, necessary to allow LICENSEE to utilize the LICENSED TECHNOLOGY. LICENSEE shall pay to LICENSOR all reasonable and customary expenses other than normal operating expenses incurred by LICENSOR in providing such training and technology transfer, including but not limited to fees incurred to request documents from patent counsel or the United States Patent and Trademark Office.
2.5 Notwithstanding anything stated herein, nothing in this Agreement shall be construed as preventing LICENSOR from practicing the LICENSED TECHNOLOGY within the FIELD for non-commercial in-house research purposes.
2.6 Notwithstanding anything stated herein, nothing in this Agreement shall be construed as preventing LICENSOR from practicing the LICENSED TECHNOLOGY within the FIELD for non-commercial in-house research purposes. In the event that LICENSOR requests that LICENSEE deliver to LICENSOR the LICENSED TECHNOLOGY or LICENSED PRODUCTS in the FIELD for research purposes, LICENSEE shall make the LICENSED TECHNOLOGY or LICENSED PRODUCTS available to LICENSOR on commercially reasonable terms. In the event LICENSOR requires the use of collaborators in its research, LICENSEE shall also make such LICENSED TECHNOLOGY OR LICENSED PRODUCTS available to such collaborator if LICENSEE, in its sole but reasonable discretion is satisfied that providing such items to a collaborator will not endanger its exclusive commercial control of such items or result in their use by a competitor.

 

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ARTICLE 3 — LICENSEE OBLIGATIONS
RELATING TO COMMERCIALIZATION
3.1 LICENSEE shall use its commercially reasonable and diligent efforts to bring one or more LICENSED PRODUCTS, LICENSED PROCESSES or LICENSED SERVICES to market through an active and diligent program for exploitation of the PATENT RIGHTS and to continue active, diligent marketing efforts for one or more LICENSED PRODUCTS, LICENSED PROCESSES or LICENSED SERVICES throughout the TERM of this Agreement.
3.2 LICENSEE shall maintain minimum R&D requirements to maintain exclusivity under this Agreement . Commencing 30 months following the Effective Date hereof and until the launch of the first human cell-based therapeutic product, LICENSEE shall be required to invest a minimum of $400,000 per year in research and development of the FIELD covered by this Agreement or other agreements with LICENSOR affecting the FIELD in order to maintain the exclusive license rights granted hereunder. In the event LICENSEE fails to perform this minimum expenditure in R&D in the FIELD during the course of a calendar year during the above-mentioned period, the license under this Agreement shall become nonexclusive and such minimum expenditure for research and development shall be reduced to $200,000 per year.
3.3 LICENSEE shall maintain complete and accurate records of LICENSED PRODUCTS, LICENSED PROCESSES and LICENSED SERVICES that are made, used, sold or performed by LICENSEE under this Agreement. Not later than April 1 st of each year following the Effective Date, LICENSEE shall furnish LICENSOR with a summary report on the progress of its efforts during the prior year to develop and commercialize LICENSED PRODUCTS, LICENSED PROCESSES or LICENSED SERVICES, including without limitation research and development efforts, efforts to obtain regulatory approval, marketing efforts (including LICENSED PRODUCTS, LICENSED PROCESSES and LICENSED SERVICES made, used, sold or performed) and sales figures, provided that such reports shall be deemed Confidential Information (as defined in Section 10.1 herein) subject to the provisions of Article 10 of this Agreement.
3.4 In the event that LICENSOR determines that LICENSEE has not fulfilled its obligations under this Article 3 , LICENSOR shall furnish LICENSEE with written notice of such determination. Within thirty (30) days after receipt of such notice, LICENSEE shall (i) fulfill the relevant obligation, (ii) negotiate with LICENSOR a mutually acceptable schedule of revised obligations, or (3) if LICENSEE disputes the alleged failure to fulfill its obligations, it shall promptly seek appropriate judicial determination of the matter and diligently pursue such action to a final determination with all appropriate speed; failing which, LICENSOR shall have the right, immediately upon written notice to LICENSEE, to terminate this Agreement as provided in Section 9.2 hereof.
ARTICLE 4 — CONSIDERATION
4.1 Initial Payment . In partial consideration of the license granted to LICENSEE from LICENSOR in Article 2 of this Agreement, LICENSEE agrees to pay a “License Fee” to LICENSOR $25,000 in a convertible promissory note in the form attached hereto as Exhibit C .

 

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4.2 Royalties .
  a)   In partial consideration of the license in the FIELD granted by LICENSOR to LICENSEE in Article 2 of this Agreement, LICENSEE agrees to pay to LICENSOR an earned royalty equal to six percent (6%) of the NET SALES in the FIELD made, used, sold, imported, exported or performed by LICENSEE in the TERRITORY.
 
  b)   No multiple royalties shall be payable because any LICENSED PRODUCT, LICENSED PROCESS or LICENSED SERVICE in the FIELD, its manufacture, use, lease, sale or performance are or shall be covered by more than one patent or patent application within the PATENT RIGHTS.
 
  c)   The obligation of LICENSEE to pay royalties hereunder shall terminate for each country in the TERRITORY concurrently with the expiration or termination of the last applicable VALID CLAIM within the PATENT RIGHTS in such country in which the LICENSED PRODUCT, LICENSED PROCESS or LICENSED SERVICE is, (as applicable), used, practiced, performed, sold, offered for sale, imported, exported or manufactured.
4.3 Minimum Royalties . Within 2 business days from the Effective Date hereof, LICENSEE shall pay to LICENSOR a minimum royalty fee of $25,000 in cash or by wire transfer. In addition, commencing 12 months following the Effective Date, LICENSEE shall pay to LICENSOR additional minimum royalty fees equal to the difference between total Royalties actually paid in the preceding 12 months and the following minimum amounts:
At 12 months, $5,000
At 24 months, $5,000
At 36 months, $5,000
Annually thereafter, $10,000.
4.4 Stacking Royalties . With the exception of minimum royalties due to LICENSOR, if LICENSEE or its Affiliates are required to pay royalties relating to any additional intellectual property from LICENSOR in order to exercise its rights hereunder to make, have made, use or sell any Product, then LICENSEE shall have the right to credit a pro-rated portion of such royalty payments against the royalties owing to LICENSOR under Section 4.2 of this Agreement with respect to sales of such Product such that in no event shall the total of royalty payments that are due to LICENSOR in such royalty period exceed the payments payable under Section 4.2 above. Prorations shall be made in the same manner as specified for combination products under Section 4.7 below.

 

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4.5 Milestone Payments. Upon the launch of a commercial therapeutic product based on the LICENSED TECHNOLOGY, LICENSEE shall pay additional Milestone Payments totaling $1,750,000 on the following schedule:
$250,000 within 30 days following the launch of the first commercial Product;
$500,000 upon reaching $5,000,000 in sales;
$1,000,000 upon reaching $10,000,000 in sales.
4.6 Stacking Milestone Payments. The milestone payments shall be in addition to any royalties specified elsewhere in this Article 4 . If LICENSEE is obligated to pay or has paid to LICENSOR similar Milestone Payments under another license agreement with respect to the FIELD, then LICENSEE shall have the right to pro-rate such Milestone Payments against the Milestone Payments owing to LICENSOR under this Agreement such that in no event shall the total of all Milestone Payments due from LICENSEE to LICENSOR exceed the payments payable under Section 4.5. Pro-rating of payments shall be made in the ratio of the minimum royalties payable under this Agreement to the minimum royalties payable under any other agreement covered hereby under which Milestone Payments are owed.
4.7 Combination Product . In the event a Product is sold in a combination product with other devices or biologically active components, NET SALES, for purposes of royalty payments on the combination product, shall be calculated by multiplying the NET SALES of that combination by the fraction A/B, where A is the gross selling price of the Product sold separately and B is the gross selling price of the combination product. In the event that no such separate sales are made by LICENSEE or its Affiliates, NET SALES for royalty determination shall be calculated by multiplying NET SALES of the combination by the fraction C/(C+D), where C is the fully allocated cost of the Product and D is the fully allocated cost of such other biologically active components.
4.8 Payments in U.S. Currency . All payments due under this Agreement shall be paid in cash to LICENSOR and all payments shall be made in United States currency. Conversion of foreign currency to U.S. dollars shall be made at the conversion rate reported in The Wall Street Journal on the last working day of the calendar quarter to which the payment relates.
4.9 Taxes . Subject to the limits of Section 1.8 hereof, all payments due hereunder shall be paid in full without deduction of taxes or other fees which may be imposed by any government and which shall be paid by LICENSEE; provided, however, that any withholding tax required to be withheld by LICENSEE on royalty payments under the laws of any country in the TERRITORY on behalf of LICENSOR will be timely paid by LICENSEE to the appropriate governmental authority, and LICENSEE will furnish LICENSOR with proof of payment of such tax. Any such tax actually withheld may be deducted from royalty payments due to LICENSOR under this Agreement. If at any time legal restrictions prevent the prompt remittance of part or all of any payments owed by LICENSEE to LICENSOR hereunder with respect to any country in the TERRITORY, payment shall be made through any lawful means or methods that may be available, and as LICENSEE shall reasonably determine is appropriate.

 

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4.10 Overdue Payments . Any payments to be made by LICENSEE hereunder that are not paid on or before the date such payments are due under this Agreement shall bear interest, to the extent permitted by law, at two percentage points above the Prime Rate of interest as reported in The Wall Street Journal on the date payment is due, with interest calculated based on the number of days that payment is delinquent.
ARTICLE 5 — REPORTS AND RECORDS
5.1 LICENSEE shall keep full, true and accurate books of account containing all particulars that may be necessary for the purpose of showing the amounts payable to LICENSOR hereunder and to enable the reports provided under Section 5.2 to be verified. Said books of account shall be kept at LICENSEE’s principal place of business. Said books and the supporting data shall be open upon reasonable advance notice (but not less than five (5) business days notice and no more frequently than once per calendar year) for three (3) years following the end of the calendar year to which they pertain, to the inspection of LICENSOR or its agents for the purpose of verifying LICENSEE’s royalty statement or compliance in other respects with this Agreement. If any such audit determines an error in any royalty payment, LICENSEE shall pay to LICENSOR, within thirty (30) days of the discovery of the error, (a) all deficiencies in royalty payments, (b) interest on such deficiencies from the date such royalty was due until the date paid at the rate set forth in Section 4.10 above, and (c) if such error is in excess of five percent (5%) of any royalty payment, the cost of the audit. In all other cases, the costs of the audit shall be paid for by LICENSOR. All information disclosed pursuant to an audit shall be treated as Confidential Information (as defined in Section 10.1 herein) and shall not be disclosed to any third party or used for any purpose other than to determine the correctness of LICENSEE’s royalty statement or compliance in other respects with this Agreement.
5.2 After the first commercial sale of a LICENSED PRODUCT or LICENSED PROCESS, LICENSED SERVICE, LICENSEE, within forty-five (45) days after March 31, June 30, September 30 and December 31 of each year, shall deliver to LICENSOR a true and accurate report, giving such particulars of the business conducted by LICENSEE during the preceding three-month period under this Agreement as shall be pertinent to a royalty accounting hereunder. Without limiting the generality of the foregoing, these reports shall include at least the following:
  a)   the number of LICENSED PRODUCTS manufactured and sold by LICENSEE;
 
  b)   total billings and the amounts actually received for LICENSED PRODUCTS sold by LICENSEE;
 
  c)   an accounting for all LICENSED PROCESSES or LICENSED SERVICES used in the provision of services to others or sold by LICENSEE;
 
  d)   the deductions applicable as provided in Section 1.9 ; and
 
  e)   the names and addresses of all parties making LICENSED PRODUCTS on behalf of LICENSEE.

 

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The reports shall provide the above-identified information by product, process, or service type.
5.3 With each such report submitted, LICENSEE shall pay to LICENSOR the royalties due and payable for such three-month period. If no royalties shall be due, LICENSEE shall so report.
ARTICLE 6 — PATENT PROSECUTION
LICENSOR shall be solely responsible for the continued prosecution of pending patent applications included in the PATENT RIGHTS and the issuance of such applications after allowance, to the extent that it has such prosecution rights. The prosecution, filing and maintenance of all patents and applications shall be the primary responsibility of LICENSOR, to the extent that it has such prosecution rights. LICENSEE agrees to cooperate fully with LICENSOR, as requested by LICENSOR and at LICENSOR’s expense, in the preparation, filing, prosecution, and maintenance of the patent applications and patents included in the PATENT RIGHTS.
ARTICLE 7 — PROSECUTION OF INFRINGERS
AND DEFENSE OF PATENT RIGHTS
The Parties agree to notify each other in writing of any actual or threatened infringement by a third party of the PATENT RIGHTS or of any claim of invalidity, unenforceability, or non-infringement of the PATENT RIGHTS. LICENSOR shall have the sole responsibility to prosecute or defend such claims, as applicable. LICENSEE shall, if requested, provide reasonable assistance to LICENSOR in connection with the prosecution or defense of such claims.
ARTICLE 8 — INDEMNIFICATION
8.1 Indemnification of the LICENSOR . LICENSEE shall be responsible for and shall indemnify, defend, and hold harmless LICENSOR, its agents, attorneys, representatives, third party beneficiaries and their respective heirs, executors, successors and assigns (collectively, the “LICENSOR Indemnitees”) from and against all liabilities of any kind whatsoever, including legal expenses and reasonable attorneys’ fees, incurred or imposed upon any of the LICENSOR Indemnitees in connection with or as a consequence of any claims (including third party claims), suits, actions, demands or judgments arising out of the death of or injury to any person or persons or out of any damage to property resulting from the development, production,

 

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manufacture, sale, use, performance, rendering, consumption or advertisement of the LICENSED PRODUCT(s) and/or LICENSED PROCESS(es), LICENSED SERVICE(s), or arising from any obligation, act or omission performed or failed to be performed hereunder, or from a breach of any representation or warranty of LICENSEE hereunder unless and to the extent that such liability arises solely from any action of LICENSOR or any of its Affiliates. If the exercise of LICENSEE’s rights under this Agreement in any country in the TERRITORY is the subject of a bona fide claim by a third party, filed in a court of competent jurisdiction after the date hereof, that the exercise of such rights infringes or conflicts with any intellectual property rights of such third party (a “Third Party Infringement Claim”), then LICENSEE shall not have any of the rights granted herein in such country and shall have no obligation to pay LICENSOR any further payments under Article 4 of this Agreement with respect to any country of the TERRITORY until such claim is resolved by proper adjudication or settlement permitting LICENSEE to exercise LICENSEE’s rights under this Agreement in the applicable country of the TERRITORY. Notwithstanding anything herein to the contrary, LICENSOR covenants that it will not (a) assert or bring any suit, action, claim or other proceeding against LICENSEE based on, in whole or in part, LICENSEE’s exercise of LICENSEE’s rights, in accordance with the terms and conditions of this Agreement, with respect to the LICENSED TECHNOLOGY and/or (b) join in any third party suit, action, claim or other proceeding against LICENSEE based on, in whole or in part, any intellectual property rights (including without limitation, patent rights and/or know how) owned by the applicable third party, so long as LICENSEE is not in violation of this Agreement.
8.2 Indemnification of the LICENSEE . LICENSOR shall be responsible for and shall indemnify, defend, and hold harmless LICENSEE and the officers, directors, shareholders, employees, agents, attorneys, representatives, and Affiliates, and their respective heirs, executors, successors and assigns. (the “LICENSEE Indemnitees”) from and against all liabilities of any kind whatsoever, including legal expenses and reasonable attorneys’ fees, incurred or imposed upon any of the LICENSEE Indemnitees in connection with or as a consequence of any claims (including third party claims), suits, actions, demands or judgments arising out of, directly or indirectly, or in any way relating to: (a) any breach by LICENSOR of any representation, warranty, covenant or obligation set forth in this Agreement; or (b) arising from LICENSOR’s ownership, management, control, use or disposition of the LICENSED TECHNOLOGY unless and to the extent that such liability arises solely from any action of LICENSEE or any of its Affiliates after the Effective Date.
8.3 Demands for Third Party Claims . Each indemnified Party hereunder (an “Indemnified Party”) agrees that promptly upon its discovery of facts giving rise to a claim for indemnity under this Agreement, including the receipt of any demand, assertion, claim, action or proceeding, judicial or otherwise, by any third party (being referred to herein as a “Claim”), with respect to any matter as to which it claims to be entitled to indemnity under the provisions of this Agreement, it will give prompt notice thereof in writing to the Indemnifying Party (the “Indemnifying Party”), together with a statement of such information respecting any of the foregoing as it shall have. Such notice shall include a formal demand for indemnification under this Agreement.

 

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8.4 Right to Contest and Defend . The Indemnifying Party shall contest and defend, at its sole cost and expense, by all appropriate legal proceedings any Claim with respect to which it is called upon to indemnify the Indemnified Party under the provisions of this Agreement; provided, that notice of the intention to so contest shall be delivered by the Indemnifying Party to the Indemnified Party as soon as reasonably possible after (but no later than twenty [20] days from) the date of receipt by the Indemnifying Party of notice by the Indemnified Party of the assertion of the Claim. Any such contest may be conducted in the name and on behalf of the Indemnifying Party or the Indemnified Party as may be appropriate. Such contest shall be conducted by reputable counsel employed by the Indemnifying Party, but the Indemnified Party shall have the right but not the obligation to participate in such proceedings and to be represented by counsel of its own choosing at its sole cost and expense. The Indemnifying Party shall have full authority to determine all action to be taken with respect thereto; provided, however, that the Indemnifying Party will not have the authority to subject the Indemnified Party to any obligation whatsoever (whether financial or the imposition of equitable or injunctive relief), other than the performance of purely ministerial tasks or obligations not involving material expense (for which the Indemnified Party shall be reimbursed). If the Indemnifying Party does not elect to contest any such Claim, the Indemnifying Party shall be bound by the result obtained with respect thereto by the Indemnified Party.
8.5 Cooperation . If requested by the Indemnifying Party, the Indemnified Party agrees to cooperate with the Indemnifying Party and its counsel in contesting any Claim that the Indemnifying Party elects to contest or, if appropriate, in making any counterclaim against the PERSON asserting the Claim, or any cross-complaint against any PERSON, and the Indemnifying Party will reimburse the Indemnified Party for any expenses incurred by it in so cooperating.
8.6 Right to Participate . The Indemnified Party agrees to afford the Indemnifying Party and its counsel the opportunity to be present at, and to participate in, conferences with any PERSON, including governmental authorities, asserting any Claim against the Indemnified Party or conferences with representatives of or counsel for such PERSON.
8.7 Payment of Damages . The Indemnifying Party shall pay to the Indemnified Party in immediately available funds any amounts to which the Indemnified Party may become entitled by reason of the provisions of this Agreement, such payment to be made within five (5) days after any such amounts are finally determined either by mutual agreement of the Parties hereto or pursuant to the final non-appealable judgment of a court of competent jurisdiction.
8.8 Independent Indemnities . The Parties acknowledge and agree that each of the indemnities under Sections 8.1 and 8.2 may be relied upon independently.

 

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8.9 Insurance. LICENSEE and LICENSOR mutually agree to maintain insurance or self-insurance that is reasonably adequate to fulfill any potential obligation to the Indemnified Parties. LICENSEE and LICENSOR shall continue to maintain such insurance or self-insurance during the term of this Agreement and after the expiration or termination of this Agreement for a period of five (5) years. Each Party shall provide to the other Party, upon request, proof of any such insurance policy maintained by such Party.
ARTICLE 9 — TERMINATION
9.1 The term of this Agreement (“TERM”) shall commence on the Effective Date and continue until the expiration of the last VALID CLAIM within the PATENT RIGHTS to expire , unless sooner terminated as provided in this Article 9 ; provided that LICENSEE’s obligation to pay royalties on NET SALES in any country will terminate pursuant to Subsection 4.2(c) (subject to LICENSEE’s obligations under Section 9.4 herein).
9.2 If either Party commits a material breach of a material term of this Agreement (including any failure to make any payment due under this Agreement), the non-breaching Party shall have the right to terminate this Agreement effective on thirty (30) days prior written notice to the Party in breach, unless such breach is cured prior to the expiration of such thirty (30) day period.
9.3 LICENSEE shall have the right to terminate this Agreement at any time on thirty (30) days prior notice to LICENSOR, and upon payment of all amounts due LICENSOR through the effective date of the termination.
9.4. Notwithstanding anything herein to the contrary, in the event that this Agreement is terminated by LICENSOR pursuant to Section 9.2 or by LICENSEE pursuant to Sections 9.2 or 9.3 , LICENSEE shall retain a license to rights granted in Article 2 to the extent reasonably necessary to sell any LICENSED PRODUCTS existing or under production and to perform LICENSED PROCESSES or LICENSED SERVICES related to such LICENSED PRODUCTS or that are in process, subject to the terms of this Agreement (including without limitation the obligation to pay royalties under Article 4 ), provided that LICENSEE shall complete and sell all such work-in-progress and inventory within six (6) months after the effective date of termination.
9.5 Upon the expiration of the TERM of this Agreement LICENSEE shall have a fully paid-up, non-exclusive, irrevocable, royalty free license under the rights granted in Article 2 .
9.6 Nothing herein shall be construed to release either Party from any obligation that accrued prior to expiration or any termination of this Agreement. The following provisions shall survive any termination or any expiration of the TERM of this Agreement: this Section 9.6 and Articles/Sections 1, 4, 5, 8, 9.4, 10, 11, 12, 13, 15.1, 15.2, 15.5, 15.6, 15.7, 15.8, 15.10, 15.15 and 15.16 , and any other provision which by its nature is intended to survive any such termination.

 

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ARTICLE 10 — CONFIDENTIALITY AND NON-DISCLOSURE
10.1 Confidential Information; Non-Disclosure . “Confidential Information” shall mean any technical, business, financial, customer or other information disclosed by one Party (the “Disclosing Party”) to the other Party (the “Receiving Party”) pursuant to this Agreement which is marked “Confidential” or “Proprietary,” or which, under all of the given circumstances, ought reasonably to be treated as confidential information of the Disclosing Party. Such information may be disclosed in oral, visual or written form (including magnetic, optical or other media). Except as expressly provided in Section 10.2 below, each Party’s Confidential Information specifically includes without limitation the respective Party’s business plans and business practices, the terms of this Agreement, scientific knowledge, research and development or know-how, processes, inventions, techniques, formulae, products and product plans, business operations, customer requirements, designs, sketches, photographs, drawings, specifications, reports, studies, findings, data, plans or other records, biological materials, software, margins, payment terms and sales forecasts, volumes and activities, designs, computer code, technical information, costs, pricing, financing, business opportunities, personnel, and information of LICENSOR or LICENSEE relating to the LICENSED PROCESSES, LICENSED PRODUCTS or LICENSED SERVICES whether or not such information is marked or identified provided that the Disclosing Party provides notice in writing reasonably identifying such Confidential Information within 30 days of disclosure. Except to the extent expressly authorized by this Agreement or by other prior written consent by the Disclosing Party, the Receiving Party, during the term of this Agreement, and thereafter, shall: (i) treat as confidential all Confidential Information of the other Party; (ii) use Confidential Information only for exercising the rights and fulfilling the obligations set forth in this Agreement, (iii) implement reasonable procedures to prohibit the disclosure, unauthorized duplication, misuse or removal of the Disclosing Party’s Confidential Information; (iv) not disclose Confidential Information to any third party, and (v) only disclose the Confidential Information to (a) those of its employees who have a need to know Confidential Information in order to exercise the rights and fulfill the obligations set forth in this Agreement and (b) legal and professional advisors and existing and potential investors and their legal and professional advisors, each of which is bound by a written agreement (or in the case of attorneys or other professional advisors, formal ethical duties) requiring such advisors and investors to treat, hold and maintain such Confidential Information in accordance with the terms and conditions of this Agreement, or (c) recipients of offering documents in connection with any offering of securities where such disclosure is, in the opinion of counsel for the Disclosing Party, reasonably required to comply with the investment disclosure laws of any applicable jurisdiction. Without limiting the foregoing, the Receiving Party shall protect the Disclosing Party’s Confidential Information using at least the same procedures and degree of care that it uses to prevent the disclosure of its own confidential information of like importance, but in no event less than reasonable care.

 

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10.2 Exceptions . The Receiving Party shall have no obligation or liability to the Disclosing Party with regard to any Confidential Information of the Disclosing Party: (i) that was publicly known and available at the time it was disclosed or becomes publicly known and available through no fault, action, or inaction of the Receiving Party; (ii) was known to the Receiving Party, without restriction, at the time of disclosure as shown by the files of the Receiving Party in existence at the time of disclosure; (iii) is disclosed with the prior written approval of the Disclosing Party; (iv) was independently developed by the Receiving Party without any use of the disclosing party’s Confidential Information, provided, that the Receiving Party can demonstrate such independent development by documented evidence prepared contemporaneously with such independent development; (v) is disclosed pursuant to the order or requirement of a court, administrative agency, or other governmental body, provided that the Receiving Party shall provide prompt notice thereof and reasonable assistance to the Disclosing Party to enable the Disclosing Party to seek a protective order or otherwise prevent such disclosure, and provided further that such disclosure is limited to the extent necessary to comply with such order and the information shall otherwise be treated as Confidential Information; or (vi) that is provided to the Receiving Party by an independent third party without violating any confidentiality obligation to the Disclosing Party.
10.3 Injunctive Relief . LICENSOR and LICENSEE acknowledge and agree that any breach of the confidentiality obligations imposed by this Article 10 will constitute immediate and irreparable harm to the Disclosing Party and/or its successors and assigns, which cannot adequately and fully be compensated by money damages and will warrant, in addition to all other rights and remedies afforded by law, injunctive relief, specific performance, and/or other equitable relief. The Disclosing Party’s rights and remedies hereunder are cumulative and not exclusive. The Disclosing Party shall also be entitled to receive from the Receiving Party the costs of enforcing this Article 10 , including reasonable attorneys’ fees and expenses of litigation.
10.4 Termination . Upon termination or expiration of this Agreement, or upon the request of the Disclosing Party at any time, the Receiving Party shall promptly return to the Disclosing Party, at its request, all copies of Confidential Information received from the Disclosing Party, and shall return or destroy, and document the destruction of, all summaries, abstracts, extracts, or other documents which contain any Confidential Information of the Disclosing Party in any form. Notwithstanding the foregoing to the contrary, LICENSEE shall have no obligation (even upon a request by LICENSOR) to return or destroy any KNOW-HOW (including tangible embodiments of KNOW-HOW) during the TERM of this Agreement.
10.5 Survival . The obligations of LICENSOR and LICENSEE under this Article 10 shall survive any expiration or termination of this Agreement.
ARTICLE 11 — PAYMENTS, NOTICES, AND OTHER COMMUNICATIONS
Any payment, notice or other communication pursuant to this Agreement shall be in writing and sent by certified first class mail, postage prepaid, return receipt requested, or by nationally recognized overnight carrier addressed to the Parties at the following addresses or such other addresses as such Party furnishes to the other Party in accordance with this paragraph. Such notices, payments, or other communications shall be effective upon receipt.

 

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In the case of LICENSOR:
Advanced Cell Technology, Inc.
One Innovation Drive
Worcester, MA 01605
Attention: Michael D. West, Ph.D., President
With a copy to:
Pierce Atwood
One Monument Square
Portland, ME 04101
Attention: William L. Worden, Esq.
In the case of LICENSEE:
PacGen Cellco, LLC.
157 Surfview Drive
Pacific Palisades, CA 90272
Attention: Kenneth Aldrich
With a copy to:
Gray Cary Ware & Freidenrich
4365 Executive Drive, Suite 1100
San Diego, CA 92121-2133
Attention: Lisa Haile
ARTICLE 12 — RESPRESENTATIONS AND WARRANTIES OF LICENSOR
As an inducement to LICENSEE to enter into and perform this Agreement, LICENSOR represents and warrants to LICENSEE as follows:
12.1 Title to LICENSED TECHNOLOGY; Encumbrances . LICENSOR has good and valid title or valid licenses (with the right of sublicense) to the LICENSED TECHNOLOGY.
12.2 No Violations . The execution, delivery and performance of this Agreement by LICENSOR and the consummation by LICENSOR of the transactions contemplated hereby does not,: (a) violate any statute, ordinance, rule or regulation applicable to LICENSOR or by which any of the LICENSED TECHNOLOGY may be bound; (b) violate any order, judgment or decree of any court or of any Governmental Authority or regulatory body, agency or authority applicable to LICENSOR or by which any of the LICENSED TECHNOLOGY may be bound; (c) require any filing by LICENSOR with, or require LICENSOR to obtain any permit, consent or approval of, or require LICENSOR to give any notice to, any Governmental Authority or regulatory body, agency or authority; or (d) result in a violation or breach by LICENSOR of, conflict with, constitute a default by LICENSOR (or give rise to any right of termination, cancellation, payment or acceleration) under or result in the creation of any Encumbrance upon any of the LICENSED TECHNOLOGY.

 

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12.3 Litigation . Except as set forth in Exhibit C , there is no action, suit, proceeding at law or in equity, arbitration or administrative or other proceeding by or before (or any investigation by) any governmental or other instrumentality or agency, pending, or threatened, against or affecting the LICENSED TECHNOLOGY, and LICENSOR does not know of any valid basis for any such action, proceeding or investigation. To the knowledge of LICENSOR, there are no such suits, actions, claims, proceedings or investigations pending or threatened, seeking to prevent or challenge the transactions contemplated by this Agreement.
12.4 Disclosure . Neither these representations and warranties made by LICENSOR pursuant to this Agreement nor any of the exhibits, schedules or certificates attached hereto or delivered in accordance with the terms hereof knowingly contains any misstatement of fact or omits any statement of fact necessary in order to make the statements contained herein and therein not misleading in light of the circumstances under which they were made.
12.5 Copies of Documents . LICENSOR has caused to be made available for inspection and copying by LICENSEE and its advisers, true, complete and correct copies of all documents in LICENSOR’s possession referred to in any schedule attached hereto.
12.6 Broker’s or Finder’s Fees . No agent, broker, person or firm acting on behalf of LICENSOR is, or will be, entitled to any fee, commission or broker’s or finder’s fees for which the LICENSEE may be liable in connection with this Agreement or any of the transactions contemplated hereby.
12.7 LICENSED TECHNOLOGY .
  (a)   Except as set forth on Exhibit D , LICENSOR, LICENSOR is not aware of any interference, infringement, misappropriation, or other conflict with any intellectual property rights of third parties, and LICENSOR has never received any charge, complaint, claim, demand, or notice alleging any such interference, infringement, misappropriation, or violation (including any claim that LICENSOR must license or refrain from using any intellectual property rights of any third party). To the knowledge of LICENSOR, no third party has interfered with, infringed upon, misappropriated, or otherwise come into conflict with any of the LICENSED TECHNOLOGY.
 
  (b)   Exhibit A identifies each patent or registration which has been issued to LICENSOR with respect to any of the LICENSED TECHNOLOGY and identifies each pending patent application or application for registration which LICENSOR has made with respect to any of the LICENSED TECHNOLOGY. LICENSOR has made available to LICENSEE correct and complete copies of all such patents, registrations and applications (as amended to-date) in LICENSOR’s possession and has made available to LICENSEE correct and complete copies of all other written documentation in LICENSOR’s possession evidencing ownership and prosecution (if applicable) of each such item.

 

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  (c)   Exhibit A identifies each item of LICENSED TECHNOLOGY that LICENSOR uses pursuant to license, sublicense, agreement, or permission. LICENSOR has made available to LICENSEE correct and complete copies of all such licenses, sublicenses, agreements, patent prosecution files and permissions (as amended to-date) in LICENSOR’s possession. With respect to each item of LICENSED TECHNOLOGY required to be identified in Exhibit A and to the knowledge of LICENSOR: (i) the license, sublicense, agreement, or permission covering the item is legal, valid, binding, enforceable, and in full force and effect; (ii) the license, sublicense, agreement, or permission will continue to be legal, valid, binding, enforceable, and in full force and effect on identical terms following the consummation of the transactions contemplated hereby; (iii) no Party to the license, sublicense, agreement, or permission is in breach or default, and no event has occurred which with notice or lapse of time would constitute a breach or default or permit termination, modification, or acceleration thereunder; (iv) no party to the license, sublicense, agreement, or permission has repudiated any provision thereof; (v) the underlying item of LICENSED TECHNOLOGY is not subject to any outstanding lien or encumbrance, injunction, judgment, order, decree, ruling, or charge; (vi) no action, suit, proceeding, hearing, investigation, charge, complaint, claim, or demand is pending or is threatened which challenges the legality, validity, or enforceability of the underlying item of LICENSED TECHNOLOGY; and (vii) LICENSOR has not granted any sublicense or similar right to the LICENSED TECHNOLOGY within the FIELD.
12.8 Survival of Representations and Warranties .
  (a)   Except as otherwise provided herein, notwithstanding any investigation at any time made by or on behalf of any Party hereto, the representations and warranties set forth herein and in any certificate delivered in connection herewith with respect to any of those representations and warranties will survive the Effective Date until the longer to occur of: (i) two (2) years or (ii) the expiration of the applicable statutes of limitation, including all periods of extension and tolling whereupon they will terminate and expire.

 

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  (b)   After a representation and warranty has expired, as provided in Subsection 12.8(a) , no claim for claims or costs may be made or prosecuted by any Person who would have been entitled to claims or costs on the basis of that representation and warranty prior to its termination and expiration, provided that no claim presented in writing for claims or costs to the Person or Persons from which or whom those damages are sought on the basis of that representation and warranty prior to its termination and expiration will be affected in any way by that termination and expiration.
12.9 EXCEPT AS OTHERWISE EXPRESSLY SET FORTH IN THIS AGREEMENT, LICENSOR, ITS DIRECTORS, OFFICERS, EMPLOYEES, AND AFFILIATES MAKE NO REPRESENTATIONS AND EXTEND NO WARRANTIES OF ANY KIND, EITHER EXPRESS OR IMPLIED, INCLUDING BUT NOT LIMITED TO WARRANTIES OF MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE, VALIDITY OF PATENT RIGHTS, ISSUED OR PENDING, AND THE ABSENCE OF LATENT OR OTHER DEFECTS, WHETHER OR NOT DISCOVERABLE. NOTHING IN THIS AGREEMENT SHALL BE CONSTRUED AS A REPRESENTATION MADE OR WARRANTY GIVEN BY LICENSOR THAT THE PRACTICE BY LICENSEE OF THE LICENSE GRANTED HEREUNDER SHALL NOT INFRINGE THE PATENT RIGHTS OF ANY THIRD PARTY.
ARTICLE 13—REPRESENTATIONS AND WARRANTIES OF LICENSEE.
LICENSEE represents and warrants to LICENSOR as follows:
13.1 Existence and Good Standing: Power and Authority . LICENSEE is a limited liability company duly organized, validly existing and in good standing under the laws of the state of California. LICENSEE has full corporate power and authority to make, execute, deliver and perform this Agreement, to perform its obligations hereunder and to consummate the transactions contemplated hereby. The execution, delivery and performance of this Agreement by LICENSEE and the consummation by it of the transactions contemplated hereby, have been duly authorized and approved by all required corporate action of LICENSEE and no other action on the part of LICENSEE is necessary to authorize the execution, delivery and performance of this Agreement by LICENSEE and the consummation of the transaction contemplated hereby. This Agreement has been duly executed and delivered by LICENSEE and is a valid and binding obligation of LICENSEE enforceable against it in accordance with its terms, except to the extent that its enforceability may be subject to applicable bankruptcy, insolvency, reorganization, moratorium and similar laws affecting the enforcement of creditors’ rights generally and by general equitable principles.

 

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13.2 Authorization and Validity of Agreement . LICENSEE has full power and authority, including full corporate power and authority, to execute and deliver this Agreement, to perform its obligations hereunder and to consummate the transactions contemplated hereby. Without limiting the foregoing, the execution, delivery and performance of this Agreement by LICENSEE and the consummation by it of the transactions contemplated hereby, have been duly authorized and approved by the members and managers of LICENSEE, and no other action on the part of LICENSEE or its officers, directors or shareholder is necessary to authorize the execution, delivery and performance of this Agreement by LICENSEE and the consummation of the transactions contemplated hereby. This Agreement has been duly executed and delivered by LICENSEE and is a valid and binding obligation of LICENSEE enforceable against it in accordance with its terms, except to the extent that its enforceability may be subject to applicable bankruptcy, insolvency, reorganization, moratorium and similar laws affecting the enforcement of creditors’ rights generally and by general equitable principles.
13.3 Consents and Approvals; No Violations . The execution, delivery and performance of this Agreement by LICENSEE and the consummation by LICENSEE of the transactions contemplated hereby will not, with or without the giving of notice or the lapse of time or both: (a) violate, conflict with, or result in a breach or default under any provision of the organizational documents of LICENSEE; (b) violate any statute, ordinance, rule or regulation applicable to LICENSEE, (c) violate any order, judgment or decree of any court or of any governmental or regulatory body, agency or authority applicable to LICENSEE or by which any of the LICENSED TECHNOLOGY may be bound; or (d) require any filing by LICENSEE with, or require LICENSEE to obtain any permit, consent or approval of, or require LICENSEE to give any notice to, any governmental or regulatory body, agency or authority, except filings, if any, which may be required under the “Blue Sky” laws of Massachusetts or as may be required in the future to comply with governmental regulations governing the production and sale of products by LICENSEE as it conducts its business.
13.4 Survival of Representations and Warranties .
  (a)   Except as otherwise provided herein, notwithstanding any investigation at any time made by or on behalf of any Party hereto, the representations and warranties set forth herein and in any certificate delivered in connection herewith with respect to any of those representations and warranties will survive the Effective Date until the longer to occur of: (i) two (2) years or (ii) the expiration of the applicable statutes of limitation, including all periods of extension and tolling whereupon they will terminate and expire.
 
  (b)   After a representation and warranty has expired, as provided in Subsection 13.4(a) , no claim for claims or costs may be made or prosecuted by any Person who would have been entitled to claims or costs on the basis of that representation and warranty prior to its termination and expiration, provided that no claim presented in writing for claims or costs to the Person or Persons from which or whom those damages are sought on the basis of that representation and warranty prior to its termination and expiration will be affected in any way by that termination and expiration.

 

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ARTICLE 14 — LIMITATION OF LIABILITY
EXCEPT FOR ANY LIABILITY TO ANY THIRD PARTIES PURSUANT TO ARTICLE 8 OR TO A PARTY PURSUANT TO ARTICLES 12 AND 13 OF THIS AGREEMENT, IN NO EVENT SHALL LICENSOR OR LICENSEE OR THEIR, ITS DIRECTORS, OFFICERS, EMPLOYEES OR AFFILIATES BE LIABLE FOR INCIDENTAL OR CONSEQUENTIAL DAMAGES OF ANY KIND, INCLUDING ECONOMIC DAMAGE OR INJURY TO PROPERTY AND LOST PROFITS, REGARDLESS OF WHETHER LICENSOR OR LICENSEE SHALL BE ADVISED, SHALL HAVE OTHER REASON TO KNOW, OR IN FACT SHALL KNOW OF THE POSSIBILITY OF SUCH DAMAGES.
ARTICLE 15 — MISCELLANEOUS PROVISIONS
15.1 CORPORATE PARTNERSHIPS. In the event LICENSEE enters into a corporate partnership for the joint development of any of the LICENSED TECHNOLOGY, then payments required hereunder shall not include funds provided for sponsored research or equity investments by any third party so long as such payments do not constitute a majority of funds transferred by such third party. However if the sponsored research involves fees in excess of industry standard reimbursement for FTEs or any equity investment in excess of fair market value, LICENSEE shall pay to LICENSOR a royalty on such excess fees calculated at the rates specified herein.
15.2 LICENSEE “REVERSE LICENSE” TO LICENSOR. LICENSEE agrees to license to LICENSOR on a non-exclusive basis for therapeutic uses in the treatment of blood and cardiovascular diseases the rights to any technology it currently owns or has licensed or develops or licenses in the future that is applicable to such diseases (excluding however the use of proprietary techniques now or hereafter developed by LICENSEE for the enhanced vascularization of transplanted cells or tissues). Such license shall provide for royalty payments at the same rate as LICENSEE’S royalty payments to LICENSOR hereunder as provided in Section 4.2(a). Such license will be sublicensable only once in a given field of use; or for the purpose of having products produced, made, or distributed; or in connection with a merger or consolidation of LICENSOR into another company or a sale of all or substantially all of the assets of LICENSOR. LICENSEE shall also have no obligations hereunder with respect to technology licenses it has or may acquire if such licenses restrict sublicensing in a manner inconsistent with this subparagraph. Such “Reverse License shall not apply to any rights acquired by LICENSEE under Section 15.18 hereof.
15.3 FUTURE TECHNOLOGY LICENSES. LICENSOR acknowledges that it is continuing to develop cell-based technology, the existence or significance of which it may not have disclosed to LICENSEE. Therefore, LICENSOR further agrees that in the event any of its technology now perfected or pending as of the date of this agreement but not specifically enumerated herein would inhibit or adversely affect the commercial use by LICENSEE of the PATENT RIGHTS in the field, LICENSOR shall waive any claim of infringement to the extent

 

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necessary to permit LICENSEE to continue the use of the PATENT RIGHTS under this Agreement. In addition, LICENSOR agrees to license to LICENSEE on a non-exclusive basis for uses in the FIELDS, including any rights acquired under Section 15.18 hereof, the rights to any technology it currently owns or has licensed or develops or licenses in the future that is applicable to such FIELDS (but specifically excluding applications involving the use of cells in the treatment of tumors where the primary use of the cells is the destruction or reduction of tumors and does not involve regeneration of tissue or organ function). Such license shall provide for royalty payments at the same rate as LICENSEE’S royalty to LICENSOR hereunder as provided in Section 4.2(a). Such license will be sublicensable only once in a given field of use; or for the purpose of having products produced, made, or distributed; or in connection with a merger or consolidation of LICENSEE into another company or a sale of all or substantially all of the assets of LICENSEE. LICENSOR shall also have no obligations hereunder with respect to technology licenses it has or may acquire if such licenses restrict sublicensing in a manner inconsistent with this subparagraph.
15.4 LICENSEE shall comply with all local, state, federal and international laws and regulations relating to the development, manufacture, use, provision, and sale of LICENSED PRODUCTS, LICENSED PROCESSES and LICENSED SERVICES. Without limiting the generality of the foregoing, LICENSEE agrees to comply with the following:
  a)   LICENSEE shall obtain all necessary approvals from the FDA, USDA, or any similar governmental authorities of any foreign jurisdiction in which LICENSEE intends to make, use, or sell LICENSED PRODUCTS or to perform LICENSED PROCESSES or LICENSED SERVICES.
 
  b)   LICENSEE shall comply fully with any and all applicable local, state, federal and international laws and regulations relating to the LICENSED PRODUCTS, LICENSED PROCESSES and LICENSED SERVICES, and the PATENT RIGHTS, in the TERRITORY, including without limitation all export or import regulations and rules now in effect or as may be issued from time to time by any governmental authority which has jurisdiction relating to the export of LICENSED PRODUCTS, LICENSED PROCESSES or LICENSED SERVICES and any technology relating thereto. LICENSEE hereby gives written assurance that it will comply with all such import or export laws and regulations (including without limitation all Export Administration Regulations of the United States Department of Commerce), that it bears sole responsibility for any violation of such laws and regulations, and that it will indemnify, defend, and hold LICENSOR harmless (in accordance with Article 8 ) for the consequences of any such violation.

 

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  c)   To the extent that any invention claimed in the PATENT RIGHTS has been partially funded by the United States Government, and only to the extent required by applicable laws and regulations, LICENSEE agrees that any LICENSED PRODUCTS used or sold in the United States will be manufactured substantially in the United States or its territories. Current law provides that if a domestic manufacturer is not commercially feasible under the circumstances, LICENSOR may seek a waiver of this requirement from the relevant federal agency on behalf of LICENSEE and, upon LICENSEE’S request, shall cooperate with LICENSEE in seeking such a waiver.
15.5 LICENSEE shall not create or incur or cause to be incurred or to exist any lien, encumbrance, pledge, charge, restriction or other security interest of any kind upon the PATENT RIGHTS, but may cause to be incurred or to exist a lien, encumbrance, pledge, charge, restriction or other security interest on its rights to the LICENSED TECHNOLOGY hereunder, provided such security interest does not affect LICENSOR’s rights to the LICENSED TECHNOLOGY, or any of LICENSOR’s rights under this Agreement.
15.6 Neither Party shall originate any publicity, news release or other public announcement (“Announcements”), written or oral, relating to this Agreement or the existence of an arrangement between the Parties, without the prior written approval of the other Party, which approval shall not be unreasonably withheld or delayed, except as otherwise required by law. The foregoing notwithstanding, LICENSOR and LICENSEE shall have the right to make such Announcements without the consent of the other Party in any prospectus, offering memorandum, or other document or filing required by applicable securities laws or other applicable law or regulation, provided that such Party shall have given the other Party at least ten (10) days prior written notice of the proposed text for the purpose of giving the other Party the opportunity to comment on such text.
15.7 No implied licenses are granted pursuant to the terms of this Agreement. No licensed rights shall be created by implication or estoppel.
15.8 Nothing herein shall be deemed to constitute either Party as the agent or representative of the Party, or both parties as joint venturers or partners for any purpose. Each Party shall be an independent contractor, not an employee or partner of the other Party, and the manner in which each Party renders its services under this Agreement shall be within its sole discretion. Neither Party shall be responsible for the acts or omissions of the other Party, nor shall either Party have authority to speak for, represent or obligate the other Party in any way without prior written authority from the other Party.
15.9 To the extent commercially feasible, and consistent with prevailing business practices and applicable law, all LICENSED PRODUCTS sold pursuant to this Agreement will be marked with the number of each issued patent that applies to such LICENSED PRODUCTS.
15.10 This Agreement shall be construed, governed, interpreted and applied in accordance with the laws of the State of California, U.S.A. without regard to principles of conflicts of law thereof, except that questions affecting the construction and effect of any patent shall be determined by the law of the country in which the patent was granted.

 

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15.11 The Parties hereto acknowledge that this Agreement sets forth the entire Agreement and understanding of the Parties hereto as to the subject matter hereof, and shall not be subject to any change or modification except by the execution of a written instrument signed by the Parties hereto.
15.12 The provisions of this Agreement are severable, and in the event that any provision of this Agreement shall be determined to be invalid or unenforceable under any controlling body of the law, such invalidity or unenforceability shall not in any way affect the validity or enforceability of the remaining provisions hereof.
15.13 The failure of either Party to assert a right hereunder or to insist upon compliance with any term or condition of this Agreement shall not constitute a waiver of that right or excuse a similar subsequent failure to perform any such term or condition by the other Party.
15.14 This Agreement may not be assigned by LICENSEE without the prior written consent of LICENSOR, which consent shall be granted or denied in LICENSOR’s sole discretion. LICENSOR may not assign this Agreement without the consent of LICENSEE, which consent shall not be unreasonably withheld or delayed, except that LICENSOR may assign this Agreement to an affiliate or to a successor in connection with the merger, consolidation, or sale of all or substantially all of its assets or that portion of its business to which this Agreement relates. Notwithstanding the foregoing to the contrary, this restriction on the assignment by LICENSEE of this Agreement shall not prevent the assignment of this Agreement in connection with a sale of all or substantially all of the assets of LICENSEE, so long as the purchaser of the assets agrees to assume to any and all outstanding liabilities to LICENSOR under this Agreement, including but not limited to any outstanding amounts under the promissory note referred to in Section 4.1 .
15.15 This Agreement has been prepared jointly and no rule of strict construction shall be applied against either Party. In this Agreement, the singular shall include the plural and vice versa and the word “including” shall be deemed to be followed by the phrase “without limitation.” The section headings contained in this Agreement are inserted for convenience only and shall not affect in any way the meaning or interpretation of this Agreement.
15.16 This Agreement may be executed in counterparts, each of which together shall constitute one and the same Agreement.
15.17 All rights and licenses granted under or pursuant to this Agreement by LICENSOR to LICENSEE are, and shall otherwise be deemed to be, for purposes of Paragraph 365(n) of the U.S. Bankruptcy Code (the “Code”), licenses to rights in “intellectual property” as defined in the Code. The Parties hereto agree that LICENSEE, as a LICENSEE of such rights under this Agreement, shall retain and may fully exercise all of its rights and elections under the Code. The Parties hereto further agree that, in the event of the commencement of a bankruptcy proceeding by or against LICENSOR including a proceeding under the Code, LICENSEE shall be entitled to a complete duplicate of (or complete access to, as appropriate) any such intellectual property and all embodiments of such intellectual property, including the PATENT RIGHTS and KNOW-HOW, and the same, if not already in LICENSEE’s possession, shall be promptly delivered to LICENSEE upon any such commencement of a bankruptcy proceeding upon written request therefore by LICENSEE.

 

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15.18 In addition to the other rights granted herein, LICENSOR hereby grants to LICENSEE a 90 day right of negotiation with respect to any technology that would constitute LICENSED TECHNOLOGY if the FIELD included diseases related either to the heart or to neuro degenerative diseases (the “Added Fields”) prior to LICENSOR entering into any license relating to either of such Added Fields) with a third party. Such a 90 day period shall commence on the earlier of the 12 month anniversary of the Effective Date, or such date when LICENSOR notifies LICENSEE that it has opened negotiations with a third party or that a third party has made inquiry about such a license. If following the expiration of any such 90-day negotiation period LICENSEE and LICENSOR have not entered into a license for an Added Field, LICENSOR shall be free to enter into an exclusive or non-exclusive license for such Added Field with any third party. If LICENSOR enters into a non-exclusive license for an Added Field with a third party following the 90-day negotiating period hereunder, LICENSOR shall offer a non-exclusive license to LICENSEE on comparable terms as those entered into with such third party. LICENSEE shall then have 30 days to enter into such a nonexclusive license. If LICENSEE does not enter into such a license within said 30-day period, LICENSOR shall have no further obligations relating to the Added Field.
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IN WITNESS WHEREOF, the Parties have duly executed this Agreement on the EFFECTIVE DATE.
ADVANCED CELL TECHNOLOGY, INC.
         
By:
  /S/ MICHAEL D. WEST
 
   
Printed Name: Michael D. West, Ph.D.    
Title: President & Chief Executive Officer    
PACGEN CELLCO, LLC
         
By:
  /S/ KENNETH ALDRICH
 
   
Printed Name: Kenneth Aldrich    
Title: Managing Member    

 

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EXHIBIT A
PATENT RIGHTS
(Reference Section 1.10)
                 
Serial No.       Filing Date        
Patent No.   CO   Issue Date   Title   Assignee
348,769
 
6,107,543
  US   1994-12-02   Culture of Totipotent Embryonic Inner Cells Mass Cells and Production of Bovine Animals   Infigen
 
               
01115354.1
 
EP 1149898
  EP   1994-12-23   Embryonic Stem Cells as Nuclear Donors and Nuclear Transfer Techniques to Produce Chimeric and Transgenic Animals   Infigen
 
               
PCT/US01/18576
  WO   2001-06-07   Identification and Use of Molecular Markers Indicating Cellular Reprogramming   Infigen
 
               
PCT/US98/04345
  WO   1998-03-05   Method of Cloning Animals   Infigen
 
               
EP 0973871
  EP   1998-03-05   Method of Cloning Animals   Infigen
 
               
031,815
 
5,453,366
  US   1993-03-15   Method of Cloning Bovine Embryos   Infigen
 
               
239,922
 
6,011,197
  US   1999-01-28   Method of Cloning Bovines Using Reprogrammed Non-Embryonic Bovine Cells   Infigen
 
               
PCT/US99/26710
  WO   1999-11-12   Method of Cloning Porcine Animals   Infigen
 
               
PCT/US01/23781
  WO   2001-07-27   Method of Cloning Porcine Animals   Infigen
 
               
199,138
 
6,258,998
  US   1998-11-24   Method of Cloning Porcine Animals   Infigen
 
               
EP 1131409
  EP   1999-11-12   Method of Cloning Porcine Animals   Infigen
 
               
473,794
 
5,843,754
  US   1995-06-06   Parthenogenic Bovine Oocyte
Activation
  Infigen
 
               
016,703
 
5,496,720
  US   1993-02-10   Parthenogenic Oocyte Activation   Infigen
 
               
176,395
 
6,077,710
  US   1998-10-21   Parthenogenic Oocyte Activation   Infigen
 
               
610,744
 
6,194,202
  US   1996-03-04   Parthenogenic Oocyte Activation   Infigen
 
               
09/573,044
  US   2000-05-15   Use of embryonic stem cells as nuclear donors during nuclear transfer and use of said techniques to produce chimeric and transgenic animals   Infigen

 

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EXHIBIT B
THIS NOTE AND THE SECURITIES ISSUABLE UPON CONVERSION OF THIS NOTE HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “ACT”), OR UNDER THE SECURITIES LAWS OF APPLICABLE STATES. THESE SECURITIES ARE SUBJECT TO RESTRICTIONS ON TRANSFERABILITY AND RESALE AND MAY NOT BE TRANSFERRED OR RESOLD EXCEPT AS PERMITTED UNDER THE ACT AND THE APPLICABLE STATE SECURITIES LAWS PURSUANT TO REGISTRATION OR EXEMPTION THEREFROM.
FORM OF
CONVERTIBLE PROMISSORY NOTE
OF
PACGEN CELLCO LLC
 
$25,000.00   Made as of May 14, 2004
For value received, PacGen CellCo LLC , a California limited liability company (the “Company”), with principal offices at 157 Surfview Drive, Pacific Palisades, CA 90272, hereby promise to pay to Advanced Cell Technology, Inc., a Delaware corporation (“Holder”), or its registered assigns, the principal sum of Twenty Five Thousand Dollars ($25,000) (the “Principal Amount”).
Unless earlier paid or converted, the unpaid Principal Amount shall be due and payable on June 1, 2007 (the “Maturity Date”). On the Maturity Date, the principal shall be (i) repaid by the Company in cash to the Holder or (ii) at the Holder’s election, converted into shares of Common Stock (as defined below) at the conversion rate set forth in Subsection 2(a) below based on a determination of the Conversion Price as of the Maturity Date made not later than 60 days following the Maturity Date by the Company’s Board of Managers, acting in good faith.
This Note is issued pursuant to that certain Exclusive License Agreement dated as of May 14, 2004 (the “License Agreement”), by and among the Company and Holder, and is subject to the provisions thereof.
The following is a statement of the rights of Holder and the conditions to which this Note is subject, and to which Holder hereof, by the acceptance of this Note, agrees:
  1.   Definitions. The following definitions shall apply for all purposes of this Note:

 

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“Common Stock” means shares of or units of or other interests (as the case may be) of common equity of the Company or its successors or assigns
“Company” means the “Company” as defined above and includes any corporation, which shall succeed to or assume the obligations of the Company under this Note.
“Conversion Price” means (i) in the case of a First Equity Financing, the price paid per share for the equity securities issued in such First Equity Financing; or (ii) in the case of an Acquisition Event (as defined below) the value of one share or unit of Common Stock based upon the portion of the aggregate sale price or merger or consolidation consideration which is available to the Company’s common equity holders in connection with such Acquisition Event; or (iii) on the Maturity, the value of one share or unit of Common Stock as determined in good faith by the Board of Managers.
“First Equity Financing” means a sale or series thereof, subsequent to the date of this Note, by the Company of equity securities in which the Company receives aggregate cash proceeds of at least $5,000,000 (not including conversion of the this Note) as result of investments made by one or more bona fide third party institutional or strategic investors in exchange for the sale of shares of capital stock of the Company.
“Holder” means any person who shall at the time be the registered holder of this Note.
“Maturity Date” means the date on which this Note is either repaid or converted in whole in accordance with the terms hereunder.
“Note” means this Secured Convertible Promissory Note.
“Series A Preferred Stock” means the class of equity securities issued by the Company in the First Equity Financing.
  2.   Interest .
The principal sum outstanding under this Note shall bear no interest unless not repaid at the Maturity Date, in which event it shall thereafter bear interest at a rate equal to the lesser of (a) ten percent (10%) per annum, or (b) the maximum non-usurious rate allowed under the laws of the State of California.

 

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  3.   Conversion .
a) Automatic Conversions. This Note shall be automatically converted into that number of shares of Series A Preferred Stock equal to the quotient of (a) the aggregate principal amount of this Note then outstanding divided by (b) the Conversion Price, under the following conditions:
i) Upon the consummation of the First Equity Financing;
ii) Immediately prior to the closing of any merger, sale or other consolidation of the Company or of any sale of all or substantially all assets of the Company which occurs prior to the First Equity Financing (an “Acquisition Event”). Notwithstanding the above, and only in the event that a conversion resulting from such Acquisition Event would result in a security not traded on a national stock exchange (including NASDAQ and NASDAQ small cap), upon written notice to the Company not later than 5 days after the consummation of the Acquisition Event and notice of the Acquisition Event to the Holder of the Note, the Holder may elect to receive payment in cash of the entire outstanding principal of this Note.
b.  Conversion Mechanics . Upon the effective date of any elective or automatic conversion of this Note, the outstanding principal of this Note shall be deemed converted into shares of Series A Preferred Stock or Common Stock automatically as of such effective date without any further action by the Holder and whether or not the Note is surrendered to the Company or its transfer agent. However, the Company shall not be obligated to issue certificates evidencing the shares of the Series A Preferred Stock or Stock issuable upon such elective or automatic conversion unless such Note is either delivered to the Company or its transfer agent, or the Holder notifies the Company or its transfer agent that such Note has been lost, stolen or destroyed and executes an agreement satisfactory to the Company to indemnify the Company from any loss incurred by it in connection with such Note.
4. Reservation of Stock. If at any time the number of shares of Common Stock or other securities issuable upon conversion of this Note shall not be sufficient to effect the conversion of this Note, the Company will take such corporate action as may be necessary to increase its authorized but unissued shares of Common Stock or other securities issuable upon conversion of this Note (and any securities of the Company that the Common Stock may convert into) as shall be sufficient for such purpose.
5. Covenants of the Company. The Company covenants to, and agrees with the Holder that prior to the Maturity Date, so long as the Notes are outstanding, with the following:
a) Organization, Standing Power. The Company is a limited liability company duly organized, validly existing and in good standing under the California Limited Liability Company Act (the “CLLCA”). The Company has all requisite power and authority to conduct its business as now being conducted under the CLLCA.

 

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b) Authority; Enforceability; No Conflict . The Company has all requisite power and authority under the CLLCA to issue this Note and to carry out its obligations hereunder. The issuance of this Note by the Company has been duly and validly authorized by all requisite proceedings on the part of the Company. This Note when executed and delivered by the Company is a valid and binding obligation of the Company, enforceable against the Company in accordance with its terms, except that (i) such enforcement may be subject to bankruptcy, insolvency, reorganization, moratorium, rehabilitation, liquidation, conservatorship, receivership or other similar laws now or hereafter in effect relating to creditors’ rights generally and (ii) the remedy of specific performance and injunctive and other forms of equitable relief may be subject to equitable defenses and to the discretion of the court before which any proceeding therefor may be brought. The execution and delivery of this Note by the Company does not, and the consummation by the Company of the transaction contemplated hereby and thereby will not result in or constitute: (i) a default, breach or violation of or under the limited liability agreement of the Company, (ii) the California Limited Liability Company Act or any applicable law or (iii) any material agreement to which the Company is a party.
6. No Rights or Liabilities as Shareholder. This Note does not by itself entitle the Holder to any voting rights or other rights as a shareholder of the Company. In the absence of conversion of this Note, no provisions of this Note, and no enumeration herein of the rights or privileges of the Holder, shall cause the Holder to be a shareholder of the Company for any purpose.
7. No Impairment. The Company will not, by amendment of its limited liability agreement, or through reorganization, consolidation, merger, dissolution, issue or sale of securities, sale of assets or any other voluntary action, willfully avoid or seek to avoid the observance or performance of any of the terms of this Note, but will at all times in good faith assist in the carrying out of all such terms and in the taking of all such action as may be necessary or appropriate in order to protect the rights of the Holder under this Note against wrongful impairment. Without limiting the generality of the foregoing, the Company will take all such action as may be necessary or appropriate in order that the Company may duly and validly issue fully paid and nonassessable shares of Common Stock upon the conversion of this Note.
8. Prepayment. The Company may at any time, without penalty, prepay in whole or in part the unpaid balance of this Note. All payments will first be applied to the repayment of accrued fees and expenses, if any, then to accrued interest, if any, until all then outstanding accrued interest has been paid, and then shall be applied to the repayment of principal.
9. Notice. The Company shall give the Holder of this Note at least ten (10) days notice of any Acquisition Event.
10. Waiver and Amendment. Any provision of this Note may be amended, waived or modified only upon written consent of the Company and the Holder of the Note.
11. Waiver of Notice and Fees. The Company and all endorsers of this Note hereby waive notice, presentment, protest and notice of dishonor.

 

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12. Transfer. This Note and any rights hereunder may not be assigned, conveyed or transferred, in whole or in part, without the Company’s prior written consent, which consent shall not be unreasonably withheld. The rights and obligations of the Company and the Holder under this Note and the License Agreement shall be binding upon and benefit their respective permitted successors, assigns, heirs, administrators and transferees. However, this Note and the loans evidenced hereby may be transferred in whole or in part only by registration of such transfer on the register maintained for such purpose by or on behalf of the Company.
13. Governing Law. This Note shall be governed by and construed under the internal laws of the State of Delaware, without reference to principles of conflict of laws or choice of laws.
14. Securities Law Representations. This Note is issued to the Holder in reliance upon the Holder’s representation to the Company, which by such Holder’s execution of this Note Holder hereby confirms, that the Note will be acquired for investment for such Holder’s own account, not as a nominee or agent, and not with a view to the sale or distribution of any part thereof, and that such Holder has no present intention of selling, granting any participation in, or otherwise distributing the same. By executing this Note, such Holder further represents that such Holder has no contract, undertaking, agreement or arrangement with any person to sell, transfer, of grant participations to such person or to any third person, with respect to this Note.
15. Headings. The headings and captions used in this Note are used only for convenience and are not to be considered in construing or interpreting this Note. All references in this Note to sections and exhibits shall, unless otherwise provided, refer to sections hereof and exhibits attached hereto, all of which exhibits are incorporated herein by this reference.
16. Severability. If one or more provisions of this Note are held to be unenforceable under applicable law, such provision(s) shall be excluded from this Note and the balance of the Note shall be interpreted as if such provision(s) were so excluded and shall be enforceable in accordance with its terms.
17. Entire Agreement; Successors and Assigns. This Note constitutes the entire contract between the Company and the Holder relative to the subject matter hereof. Any previous agreement between the Company and the Holder is superseded by this Agreement. Subject to the exceptions specifically set forth in this Note, the terms and conditions of this Note shall inure to the benefit of and be binding upon the respective executors, administrators, heirs, successors and assigns of the Parties.
[Remainder of this page intentionally left blank]

 

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IN WITNESS WHEREOF , the Company has caused this Note to be signed in its name as of the date first above written.
PACGEN CELLCO LLC
         
By:
       
 
 
 
Name:
   
 
  Title:    
ACCEPTED AND AGREED TO:
ADVANCED CELL TECHNOLOGY, INC.
         
By:
       
 
 
 
Name:
   
 
  Title:    

 

 


 

EXHIBIT C
(Reference Section 12.3)
None

 

 


 

EXHIBIT D
(Reference Section 12.7)
None

 

 

 

Exhibit 10.13
EXCLUSIVE LICENSE AGREEMENT (ACT IP)
This Exclusive License Agreement (“Agreement”) is made and entered into this 14 th day of May, 2004 (the “Effective Date”), by and between Advanced Cell Technology, Inc., a Delaware corporation with offices located at One Innovation Drive, Worcester, Massachusetts 01605 (“LICENSOR”), and PacGen Cellco, LLC, a California limited liability company with offices located at 157 Surfview Drive, Pacific Palisades, CA 90272 (“LICENSEE”) (LICENSOR and LICENSEE sometimes hereinafter referred to individually as a “Party” and collectively as the “Parties”).
WITNESSETH
WHEREAS, LICENSOR owns or has licensed with sublicenseable interest the PATENT RIGHTS (as defined below) and KNOW-HOW (as defined below); and
WHEREAS, LICENSEE desires to obtain an exclusive worldwide license under LICENSOR’s rights in such technology in the FIELD; and
WHEREAS, LICENSOR is willing to grant such a license to LICENSEE upon the terms and conditions set forth below; and
NOW, THEREFORE, in consideration of the premises and the mutual covenants contained herein, the Parties hereto agree as follows:
ARTICLE 1 — DEFINITIONS
For the purposes of this Agreement, the following words and phrases shall have the following meanings:
1.1 “AFFILIATE” shall mean, with respect to any PERSON, any other PERSON which directly or indirectly controls, is controlled by, or is under common control with, such PERSON. A PERSON shall be regarded as in control of another PERSON if it owns, or directly or indirectly controls, at least fifty percent (50%) of the voting stock or other ownership interest of the other PERSON, or if it directly or indirectly possesses the power to direct or cause the direction of the management and policies of the other PERSON by any means whatsoever.
1.2 “FIELD” shall mean (1) the research, development, manufacture and selling of human and non-human animal cells for commercial research use, including small molecule and other drug testing and basic research and (2) the manufacture and selling of human cells for therapeutic and diagnostic use in the treatment of human (a) diabetes and (b) liver diseases; but FIELD shall exclude applications involving the use of cells in the treatment of tumors where the primary use of the cells is the destruction or reduction of tumors and does not involve regeneration of tissue or organ function.

 

 


 

1.3 “KNOW-HOW” means all compositions of matter, techniques and data and other know-how and technical information including inventions (whether or not patentable), improvements and developments, practices, methods, concepts, trade secrets, documents, computer data, computer code, apparatus, clinical and regulatory strategies, test data, analytical and quality control data, formulation, manufacturing, patent data or descriptions, development information, drawings, specifications, designs, plans, proposals and technical data and manuals and all other proprietary information that is owned or controlled by LICENSOR as of the Effective Date that relates to cloning technology or to any of the subject matter described in or claimed by the PATENT RIGHTS and is relevant to the FIELD. By way of illustration, but not in limitation, KNOW-HOW shall include commercial rights to any existing potential research products, including reagents, developed by LICENSOR in the course of its in-house research. An example of this is the proprietary culture medium developed by LICENSOR in the course of the development of LICENSOR’s proprietary ooplasmic transfer technology.
1.4 “LICENSED PROCESS” means any process or method, the research, development, use, practice, sale, offer for sale, import or export of which cannot be performed without (i) infringing, in whole or in part, one or more VALID CLAIMS of the PATENT RIGHTS, or (ii) using or incorporating some portion of the LICENSED TECHNOLOGY.
1.5 “LICENSED PRODUCT” means any product that cannot be developed, manufactured, used, imported, exported, or sold without (i) infringing, in whole or in part, one or more VALID CLAIMS of the PATENT RIGHTS, or (ii) using or incorporating some portion of the LICENSED TECHNOLOGY.
1.6 “LICENSED SERVICES” means any service, the developing, using, performing, selling, offering for sale, importing or exporting of which by LICENSEE would, but for the licenses granted to LICENSEE in Article 2 of this Agreement, infringe a VALID CLAIM of the PATENT RIGHTS in the country in which any such service is so developed, used, performed, sold, offered for sale, imported or exported by LICENSEE.
1.7 “LICENSED TECHNOLOGY” shall mean, collectively, the licensed PATENT RIGHTS and licensed KNOW-HOW.
1.8 “NET SALES” shall mean the amount billed or invoiced by LICENSEE for the sale or provision of LICENSED PRODUCTS or LICENSED PROCESSES or LICENSED SERVICES less:
  a)   discounts, credits, allowances and rebates allowed;
 
  b)   sales, tariff duties, use and other taxes or governmental charges directly imposed with reference to particular sales;
 
  c)   special packaging, transportation and insurance costs incurred and directly related to the sale of LICENSED PRODUCTS;
 
  d)   amounts allowed or credited on returns; and
 
  e)   uncollected accounts.

 

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1.9 “NEURONAL & HEART FIELD OPTION” means an option described in Section 15.18 hereof for LICENSEE to negotiate terms for license to the LICENSED TECHNOLOGY for the field of diseases related to heart or neurodegenerative diseases
1.10 “PATENT RIGHTS” means (a) the patent applications and patents identified on Exhibit A attached hereto and any patents that issue on said applications and (b) any divisions, continuations, extensions, reissues or reexaminations of any of the patents identified in the foregoing clause (a). The Parties agree that Exhibit A may be revised from time to time after the Effective Date to reflect changes thereto that result from the course of patent prosecution.
1.11 “PERSON” shall mean an individual, corporation, partnership, limited liability company, trust, business trust, association, joint stock company, joint venture, pool, syndicate, sole proprietorship, unincorporated organization, governmental authority or any other form of entity not specifically listed herein.
1.12 “TERM” has the meaning set forth in Section 9.1 .
1.13 “TERRITORY” means the entire world.
1.14 “VALID CLAIM” means a claim of any issued and unexpired patent within the PATENT RIGHTS which has not lapsed, become abandoned or been held permanently revoked, invalid, or unenforceable by a decision of a court or administrative or government authority or agency of competent jurisdiction from which no appeal can be or has been taken within the time allowed for such appeal, or a claim of a pending patent application included within the Licensed PATENT RIGHTS, which claim was filed in good faith and has not been abandoned or finally disallowed without the possibility of appeal or refiling of such application.
Additional terms may be defined throughout this Agreement.
ARTICLE 2 — GRANT
2.1 LICENSOR hereby grants to LICENSEE, and LICENSEE hereby accepts, subject to the terms and conditions hereof, a royalty bearing, exclusive license in the TERRITORY in the FIELD and under the LICENSED TECHNOLOGY to (a) research, develop, make, have made, use, sell, offer for sale, import and export LICENSED PRODUCTS, (b) research, develop, use, practice, sell, offer for sale, import and export LICENSED PROCESSES and (c) develop, use, perform, sell, offer for sale, import and export LICENSED SERVICES. By way of example, but not in limitation, LICENSEE shall have the right to use LICENSED TECHNOLOGY within the FIELD to produce mammalian embryonic stem (ES) cells and to produce from those mammalian embryonic cells, differentiated cells for human therapeutic purposes or for commercial research purposes, including drug screening assays, and to produce pluripotent cells including ES cells, differentiated human cells for human diagnostic and therapeutic purposes and/or for commercial research purposes, including drug screening assays.

 

3


 

2.2 LICENSEE shall have the right to sublicense the rights granted in Section 2.1 to third parties in connection with contracting with such third parties to (a) provide LICENSED PRODUCT marketing and distribution services to LICENSEE on behalf of LICENSEE, (b) provide LICENSED SERVICES marketing services to LICENSEE on behalf of LICENSEE or (c) manufacture for LICENSEE LICENSED PRODUCTS for sale by LICENSEE or a third party pursuant to the foregoing clause (a).
2.3 LICENSEE shall have the right to grant sublicenses beyond the scope of those described in Subsections 2.2 (a), (b), and (c) without the express prior written approval of LICENSOR, however, LICENSOR shall be given at least 30 days prior written notice of an intent to sublicense and at least 30 days to comment on the text of the proposed sublicense agreement. In any case, such sublicenses shall meet the following conditions:
  a)   the sublicensee shall not have the right to grant further sublicenses;
 
  b)   the sublicense shall not be assignable without prior written approval by LICENSEE and LICENSOR; and
 
  c)   the sublicense shall include fair consideration.
2.4 Within thirty (30) business days of the Effective Date, LICENSOR shall provide and transfer to LICENSEE, in writing where practicable, all information and data relating to the LICENSED TECHNOLOGY as may be reasonably necessary and requested to allow LICENSEE to exploit the licenses granted hereunder. LICENSOR shall work with LICENSEE in good faith to provide the necessary training for up to a total of 60 days, at LICENSOR’s facilities, necessary to allow LICENSEE to utilize the LICENSED TECHNOLOGY. LICENSEE shall pay to LICENSOR all reasonable and customary expenses other than normal operating expenses incurred by LICENSOR in providing such training and technology transfer, including but not limited to fees incurred to request documents from patent counsel or the United States Patent and Trademark Office.
2.5 Notwithstanding anything stated herein, nothing in this Agreement shall be construed as preventing LICENSOR from practicing the LICENSED TECHNOLOGY within the FIELD for non-commercial in-house research purposes.
2.6 Notwithstanding anything stated herein, nothing in this Agreement shall be construed as preventing LICENSOR from practicing the LICENSED TECHNOLOGY within the FIELD for non-commercial in-house research purposes. In the event that LICENSOR requests that LICENSEE deliver to LICENSOR the LICENSED TECHNOLOGY or LICENSED PRODUCTS in the FIELD for research purposes, LICENSEE shall make the LICENSED TECHNOLOGY or LICENSED PRODUCTS available to LICENSOR on commercially reasonable terms. In the event LICENSOR requires the use of collaborators in its research, LICENSEE shall also make such LICENSED TECHNOLOGY OR LICENSED PRODUCTS available to such collaborator if LICENSEE, in its sole but reasonable discretion is satisfied that providing such items to a collaborator will not endanger its exclusive commercial control of such items or result in their use by a competitor.

 

4


 

ARTICLE 3 — LICENSEE OBLIGATIONS
RELATING TO COMMERCIALIZATION
3.1 LICENSEE shall use its commercially reasonable and diligent efforts to bring one or more LICENSED PRODUCTS, LICENSED PROCESSES or LICENSED SERVICES to market through an active and diligent program for exploitation of the PATENT RIGHTS and to continue active, diligent marketing efforts for one or more LICENSED PRODUCTS, LICENSED PROCESSES or LICENSED SERVICES throughout the TERM of this Agreement.
3.2 LICENSEE shall maintain minimum R&D requirements to maintain exclusivity under this Agreement . Commencing 30 months following the Effective Date hereof and until the launch of the first human cell-based therapeutic product, LICENSEE shall be required to invest a minimum of $400,000 per year in research and development of the FIELD covered by this Agreement or other agreements with LICENSOR affecting the FIELD in order to maintain the exclusive license rights granted hereunder. In the event LICENSEE fails to perform this minimum expenditure in R&D in the FIELD during the course of a calendar year during the above-mentioned period, the license under this Agreement shall become nonexclusive and such minimum expenditure for research and development shall be reduced to $200,000 per year.
3.3 LICENSEE shall maintain complete and accurate records of LICENSED PRODUCTS, LICENSED PROCESSES and LICENSED SERVICES that are made, used, sold or performed by LICENSEE under this Agreement. Not later than April 1 st of each year following the Effective Date, LICENSEE shall furnish LICENSOR with a summary report on the progress of its efforts during the prior year to develop and commercialize LICENSED PRODUCTS, LICENSED PROCESSES or LICENSED SERVICES, including without limitation research and development efforts, efforts to obtain regulatory approval, marketing efforts (including LICENSED PRODUCTS, LICENSED PROCESSES and LICENSED SERVICES made, used, sold or performed) and sales figures, provided that such reports shall be deemed Confidential Information (as defined in Section 10.1 herein) subject to the provisions of Article 10 of this Agreement.
3.4 In the event that LICENSOR determines that LICENSEE has not fulfilled its obligations under this Article 3 , LICENSOR shall furnish LICENSEE with written notice of such determination. Within thirty (30) days after receipt of such notice, LICENSEE shall (i) fulfill the relevant obligation, (ii) negotiate with LICENSOR a mutually acceptable schedule of revised obligations, or (3) if LICENSEE disputes the alleged failure to fulfill its obligations, it shall promptly seek appropriate judicial determination of the matter and diligently pursue such action to a final determination with all appropriate speed; failing which, LICENSOR shall have the right, immediately upon written notice to LICENSEE, to terminate this Agreement as provided in Section 9.2 hereof.

 

5


 

ARTICLE 4 — CONSIDERATION
4.1 Initial Payment . In partial consideration of the license granted to LICENSEE from LICENSOR in Article 2 of this Agreement, LICENSEE agrees to pay as a “License Fee” to LICENSOR $225,000 in a convertible promissory note in the form attached hereto as Exhibit B .
4.2 Royalties .
  a)   In partial consideration of the license in the FIELD granted by LICENSOR to LICENSEE in Article 2 of this Agreement, LICENSEE agrees to pay to LICENSOR an earned royalty equal to the following percentages of the NET SALES in the FIELD made, used, sold, imported, exported or performed by LICENSEE in the TERRITORY.
(i) 6% on therapeutics,
(ii) 3% on diagnostics, and
(iii) 10% on commercial research use.
  b)   No multiple royalties shall be payable because any LICENSED PRODUCT, LICENSED PROCESS or LICENSED SERVICE in the FIELD, its manufacture, use, lease, sale or performance are or shall be covered by more than one patent or patent application within the PATENT RIGHTS.
 
  c)   The obligation of LICENSEE to pay royalties or Sublicense Income (as defined in Section 4.5 herein) hereunder shall terminate for each country in the TERRITORY concurrently with the expiration or termination of the last applicable VALID CLAIM within the PATENT RIGHTS in such country in which the LICENSED PRODUCT, LICENSED PROCESS or LICENSED SERVICE is, (as applicable), used, practiced, performed, sold, offered for sale, imported, exported or manufactured.
4.3 Minimum Royalties . Within 2 business days from the Effective Date hereof, LICENSEE shall pay to LICENSOR a minimum royalty fee of $175,000 in cash or by wire transfer. In addition, commencing 12 months following the Effective Date, LICENSEE shall pay to LICENSOR additional minimum royalty fees equal to the difference between total Royalties actually paid in the preceding 12 months and the following minimum amounts:
At 12 months, $10,000
At 24 months, $25,000
At 36 months, $40,000
Annually thereafter, $50,000.

 

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4.4 Stacking Royalties . With the exception of minimum royalties due to LICENSOR, if LICENSEE, its Affiliates or sublicensees are required to pay royalties relating to any additional intellectual property from LICENSOR in order to exercise its rights hereunder to make, have made, use or sell any Product, then LICENSEE shall have the right to credit a pro-rated portion of such royalty payments against the royalties owing to LICENSOR under Section 4.2 of this Agreement with respect to sales of such Product such that in no event shall the total of royalty payments that are due to LICENSOR in such royalty period exceed the payments payable under Subsection 4.2(a) above. Prorations shall be made in the same manner as specified for combination products under Section 4.9 below.
4.5 Sublicense Income . LICENSEE shall pay to LICENSOR a total of Thirty Three percent (33%) of all Sublicense Income. “Sublicense Income” means consideration that LICENSEE receives for the sublicense of rights that are granted LICENSEE under Article 2 , including without limitation license fees, milestone payments, equity payments, up front fees, success fees, and license maintenance fees.
4.6 Stacking Sublicense Income. The fees payable on Sublicense Income under Section 4.5 above shall be in addition to any royalties specified elsewhere in this Article 4 , but if LICENSEE is obligated to pay or has paid to LICENSOR similar fees on Sublicense Income under another license agreement with respect to the FIELD, then LICENSEE shall have the right to pro-rate such fees against the fees owing to LICENSOR under this Agreement such that in no event shall the total of fees due from LICENSEE, as a result of Sublicense Income, to LICENSOR exceed the payments payable under Section 4.5 . Pro-rating of payments shall be made in the ratio of the minimum royalties payable under this Agreement to the minimum royalties payable under any other agreement covered hereby under which fees on Sublicense Income are owed.
4.7 Milestone Payments. Upon the launch of a commercial therapeutic product based on the LICENSED TECHNOLOGY, LICENSEE shall pay additional Milestone Payments totaling $1,750,000 on the following schedule:
$250,000 within 30 days following the launch of the first commercial Product;
$500,000 upon reaching $5,000,000 in sales from one or both Product Fields;
$1,000,000 upon reaching $10,000,000 in sales from one or both Product Fields.
4.8 Stacking Milestone Payments. The milestone payments shall be in addition to any royalties specified elsewhere in this Article 4 , but shall not apply to diagnostic, commercial research, or any other non-therapeutic uses. If LICENSEE is obligated to pay or has paid to LICENSOR similar Milestone Payments under another license agreement with respect to the FIELD, then LICENSEE shall have the right to pro-rate such Milestone Payments against the

 

7


 

Milestone Payments owing to LICENSOR under this Agreement such that in no event shall the total of all Milestone Payments due from LICENSEE to LICENSOR exceed the amounts stated in Section 4.7 . Pro-rating of payments shall be made in the ratio of the minimum royalties payable under this Agreement to the minimum royalties payable under any other agreement covered hereby under which Milestone Payments are owed.
4.9 Combination Product . In the event a Product is sold in a combination product with other devices or biologically active components, NET SALES, for purposes of royalty payments on the combination product, shall be calculated by multiplying the NET SALES of that combination by the fraction A/B, where A is the gross selling price of the Product sold separately and B is the gross selling price of the combination product. In the event that no such separate sales are made by LICENSEE, its Affiliates or permitted sublicensees, NET SALES for royalty determination shall be calculated by multiplying NET SALES of the combination by the fraction C/(C+D), where C is the fully allocated cost of the Product and D is the fully allocated cost of such other biologically active components.
4.10 Payments in U.S. Currency . All payments due under this Agreement shall be paid in cash to LICENSOR and all payments shall be made in United States currency. Conversion of foreign currency to U.S. dollars shall be made at the conversion rate reported in The Wall Street Journal on the last working day of the calendar quarter to which the payment relates.
4.11 Taxes . Subject to the limits of Section 1.8 hereof, all payments due hereunder shall be paid in full without deduction of taxes or other fees which may be imposed by any government and which shall be paid by LICENSEE; provided, however, that any withholding tax required to be withheld by LICENSEE on royalty payments under the laws of any country in the TERRITORY on behalf of LICENSOR will be timely paid by LICENSEE to the appropriate governmental authority, and LICENSEE will furnish LICENSOR with proof of payment of such tax. Any such tax actually withheld may be deducted from royalty payments due to LICENSOR under this Agreement. If at any time legal restrictions prevent the prompt remittance of part or all of any payments owed by LICENSEE to LICENSOR hereunder with respect to any country in the TERRITORY, payment shall be made through any lawful means or methods that may be available, and as LICENSEE shall reasonably determine is appropriate.
4.12 Overdue Payments . Any payments to be made by LICENSEE hereunder that are not paid on or before the date such payments are due under this Agreement shall bear interest, to the extent permitted by law, at two percentage points above the Prime Rate of interest as reported in The Wall Street Journal on the date payment is due, with interest calculated based on the number of days that payment is delinquent.

 

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ARTICLE 5 — REPORTS AND RECORDS
5.1 LICENSEE shall keep full, true and accurate books of account containing all particulars that may be necessary for the purpose of showing the amounts payable to LICENSOR hereunder and to enable the reports provided under Section 5.2 to be verified. Said books of account shall be kept at LICENSEE’s principal place of business. Said books and the supporting data shall be open upon reasonable advance notice (but not less than five (5) business days notice and no more frequently than once per calendar year) for three (3) years following the end of the calendar year to which they pertain, to the inspection of LICENSOR or its agents for the purpose of verifying LICENSEE’s royalty and Sublicense Income statement or compliance in other respects with this Agreement. If any such audit determines an error in any royalty or Sublicense Income payment, LICENSEE shall pay to LICENSOR, within thirty (30) days of the discovery of the error, (a) all deficiencies in royalty or Sublicense Income payments, (b) interest on such deficiencies from the date such royalty or Sublicense Income payment was due until the date paid at the rate set forth in Section 4.10 above, and (c) if such error is in excess of five percent (5%) of any royalty or Sublicense Income payment, the cost of the audit. In all other cases, the costs of the audit shall be paid for by LICENSOR. All information disclosed pursuant to an audit shall be treated as Confidential Information (as defined in Section 10.1 herein) and shall not be disclosed to any third party or used for any purpose other than to determine the correctness of LICENSEE’s royalty and Sublicense Income statement or compliance in other respects with this Agreement.
5.2 After the first commercial sale of a LICENSED PRODUCT, LICENSED PROCESS, or LICENSED SERVICE, LICENSEE, within forty-five (45) days after March 31, June 30, September 30 and December 31 of each year, shall deliver to LICENSOR a true and accurate report, giving such particulars of the business conducted by LICENSEE and its permitted sublicensees during the preceding three-month period under this Agreement as shall be pertinent to a royalty and Sublicense Income accounting hereunder. Without limiting the generality of the foregoing, these reports shall include at least the following:
  a)   the number of LICENSED PRODUCTS manufactured and sold by LICENSEE and all sublicensees;
 
  b)   total billings and the amounts actually received for LICENSED PRODUCTS sold by LICENSEE and all sublicensees;
 
  c)   an accounting for all LICENSED PROCESSES or LICENSED SERVICES used in the provision of services to others or sold by LICENSEE;
 
  d)   the deductions applicable as provided in Section 1.8 ; and
 
  e)   the names and addresses of all parties making LICENSED PRODUCTS on behalf of LICENSEE.
The reports shall provide the above-identified information by product, process, or service type.

 

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5.3 With each such report submitted, LICENSEE shall pay to LICENSOR the royalties and Sublicense Income due and payable for such three-month period. If no royalties or Sublicense Income shall be due, LICENSEE shall so report.
ARTICLE 6 — PATENT PROSECUTION
6.1 LICENSOR shall be solely responsible for the continued prosecution of pending patent applications included in the PATENT RIGHTS and the issuance of such applications after allowance. The prosecution, filing and maintenance of all patents and applications shall be the primary responsibility of LICENSOR. LICENSEE agrees to cooperate fully with LICENSOR, as requested by LICENSOR and at LICENSOR’s expense, in the preparation, filing, prosecution, and maintenance of the patent applications and patents included in the PATENT RIGHTS. With respect to Australia, Canada, Europe, Mexico, Japan and Israel, LICENSEE shall pay to LICENSOR on or before the due date one half (1/2) of any future annuity and maintenance fees with respect to filings stemming from applications 10/227,282, PCT/US02/26945 and 60/539,796, provided LICENSOR notifies LICENSEE of the amount of such payments due at least 30 days prior to their due date.
ARTICLE 7 — PROSECUTION OF INFRINGERS
AND DEFENSE OF PATENT RIGHTS
The Parties agree to notify each other in writing of any actual or threatened infringement by a third party of the PATENT RIGHTS or of any claim of invalidity, unenforceability, or non-infringement of the PATENT RIGHTS. LICENSOR shall have the sole responsibility to prosecute or defend such claims, as applicable. LICENSEE shall, if requested, provide reasonable assistance to LICENSOR in connection with the prosecution or defense of such claims.
ARTICLE 8 — INDEMNIFICATION
8.1 Indemnification of the LICENSOR . LICENSEE shall be responsible for and shall indemnify, defend, and hold harmless LICENSOR, its agents, attorneys, representatives, third party beneficiaries and their respective heirs, executors, successors and assigns (collectively, the “LICENSOR Indemnitees”) from and against all liabilities of any kind whatsoever, including legal expenses and reasonable attorneys’ fees, incurred or imposed upon any of the LICENSOR Indemnitees in connection with or as a consequence of any claims (including third party claims), suits, actions, demands or judgments arising out of the death of or injury to any person or persons or out of any damage to property resulting from the development, production, manufacture, sale, use, performance, rendering, consumption or advertisement of the

 

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LICENSED PRODUCT(s), LICENSED PROCESS(es), and/or LICENSED SERVICE(s), or arising from any obligation, act or omission performed or failed to be performed hereunder, or from a breach of any representation or warranty of LICENSEE hereunder unless and to the extent that such liability arises solely from any action of LICENSOR or any of its Affiliates. If the exercise of LICENSEE’s rights under this Agreement in any country in the TERRITORY is the subject of a bona fide claim by a third party, filed in a court of competent jurisdiction after the date hereof, that the exercise of such rights infringes or conflicts with any intellectual property rights of such third party (a “Third Party Infringement Claim”), then LICENSEE shall not have any of the rights granted herein in such country and shall have no obligation to pay LICENSOR any further payments under Article 4 of this Agreement with respect to any country of the TERRITORY until such claim is resolved by proper adjudication or settlement permitting LICENSEE to exercise LICENSEE’s rights under this Agreement in the applicable country of the TERRITORY. Notwithstanding anything herein to the contrary, LICENSOR covenants that it will not (a) assert or bring any suit, action, claim or other proceeding against LICENSEE based on, in whole or in part, LICENSEE’s exercise of LICENSEE’s rights, in accordance with the terms and conditions of this Agreement, with respect to the LICENSED TECHNOLOGY and/or (b) join in any third party suit, action, claim or other proceeding against LICENSEE based on, in whole or in part, any intellectual property rights (including without limitation, patent rights and/or know how) owned by the applicable third party, so long as LICENSEE is not in violation of this Agreement.
8.2 Indemnification of the LICENSEE . LICENSOR shall be responsible for and shall indemnify, defend, and hold harmless LICENSEE and the officers, directors, shareholders, employees, agents, attorneys, representatives, and Affiliates, and their respective heirs, executors, successors and assigns. (the “LICENSEE Indemnitees”) from and against all liabilities of any kind whatsoever, including legal expenses and reasonable attorneys’ fees, incurred or imposed upon any of the LICENSEE Indemnitees in connection with or as a consequence of any claims (including third party claims), suits, actions, demands or judgments arising out of, directly or indirectly, or in any way relating to: (a) any breach by LICENSOR of any representation, warranty, covenant or obligation set forth in this Agreement; or (b) arising from LICENSOR’s ownership, management, control, use or disposition of the LICENSED TECHNOLOGY unless and to the extent that such liability arises solely from any action of LICENSEE or any of its Affiliates after the Effective Date.
8.3 Demands for Third Party Claims . Each indemnified Party hereunder (an “Indemnified Party”) agrees that promptly upon its discovery of facts giving rise to a claim for indemnity under this Agreement, including the receipt of any demand, assertion, claim, action or proceeding, judicial or otherwise, by any third party (being referred to herein as a “Claim”), with respect to any matter as to which it claims to be entitled to indemnity under the provisions of this Agreement, it will give prompt notice thereof in writing to the Indemnifying Party (the “Indemnifying Party”), together with a statement of such information respecting any of the foregoing as it shall have. Such notice shall include a formal demand for indemnification under this Agreement.

 

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8.4 Right to Contest and Defend . The Indemnifying Party shall contest and defend, at its sole cost and expense, by all appropriate legal proceedings any Claim with respect to which it is called upon to indemnify the Indemnified Party under the provisions of this Agreement; provided, that notice of the intention to so contest shall be delivered by the Indemnifying Party to the Indemnified Party as soon as reasonably possible after (but no later than twenty [20] days from) the date of receipt by the Indemnifying Party of notice by the Indemnified Party of the assertion of the Claim. Any such contest may be conducted in the name and on behalf of the Indemnifying Party or the Indemnified Party as may be appropriate. Such contest shall be conducted by reputable counsel employed by the Indemnifying Party, but the Indemnified Party shall have the right but not the obligation to participate in such proceedings and to be represented by counsel of its own choosing at its sole cost and expense. The Indemnifying Party shall have full authority to determine all action to be taken with respect thereto; provided, however, that the Indemnifying Party will not have the authority to subject the Indemnified Party to any obligation whatsoever (whether financial or the imposition of equitable or injunctive relief), other than the performance of purely ministerial tasks or obligations not involving material expense (for which the Indemnified Party shall be reimbursed). If the Indemnifying Party does not elect to contest any such Claim, the Indemnifying Party shall be bound by the result obtained with respect thereto by the Indemnified Party.
8.5 Cooperation . If requested by the Indemnifying Party, the Indemnified Party agrees to cooperate with the Indemnifying Party and its counsel in contesting any Claim that the Indemnifying Party elects to contest or, if appropriate, in making any counterclaim against the PERSON asserting the Claim, or any cross-complaint against any PERSON, and the Indemnifying Party will reimburse the Indemnified Party for any expenses incurred by it in so cooperating.
8.6 Right to Participate . The Indemnified Party agrees to afford the Indemnifying Party and its counsel the opportunity to be present at, and to participate in, conferences with any PERSON, including governmental authorities, asserting any Claim against the Indemnified Party or conferences with representatives of or counsel for such PERSON.
8.7 Payment of Damages . The Indemnifying Party shall pay to the Indemnified Party in immediately available funds any amounts to which the Indemnified Party may become entitled by reason of the provisions of this Agreement, such payment to be made within five (5) days after any such amounts are finally determined either by mutual agreement of the Parties hereto or pursuant to the final non-appealable judgment of a court of competent jurisdiction.
8.8 Independent Indemnities . The Parties acknowledge and agree that each of the indemnities under Sections 8.1 and 8.2 may be relied upon independently.
8.9 Insurance. LICENSEE and LICENSOR mutually agree to maintain insurance or self-insurance that is reasonably adequate to fulfill any potential obligation to the Indemnified Parties. LICENSEE and LICENSOR shall continue to maintain such insurance or self-insurance during the term of this Agreement and after the expiration or termination of this Agreement for a period of five (5) years. Each Party shall provide to the other Party, upon request, proof of any such insurance policy maintained by such Party.

 

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ARTICLE 9 — TERMINATION
9.1 The term of this Agreement (“TERM”) shall commence on the Effective Date and continue until the expiration of the last VALID CLAIM within the PATENT RIGHTS to expire , unless sooner terminated as provided in this Article 9 ; provided that LICENSEE’s obligation to pay royalties or Sublicense Income on NET SALES in any country will terminate pursuant to Subsection 4.2(c) (subject to LICENSEE’s obligations under Section 9.4 herein).
9.2 If either Party commits a material breach of a material term of this Agreement (including any failure to make any payment due under this Agreement), the non-breaching Party shall have the right to terminate this Agreement effective on thirty (30) days prior written notice to the Party in breach, unless such breach is cured prior to the expiration of such thirty (30) day period.
9.3 LICENSEE shall have the right to terminate this Agreement at any time on thirty (30) days prior notice to LICENSOR, and upon payment of all amounts due LICENSOR through the effective date of the termination.
9.4. Notwithstanding anything herein to the contrary, in the event that this Agreement is terminated by LICENSOR pursuant to Section 9.2 or by LICENSEE pursuant to Sections 9.2 or 9.3 , LICENSEE shall retain a license to rights granted in Article 2 to the extent reasonably necessary to sell any LICENSED PRODUCTS existing or under production and to perform LICENSED PROCESSES or LICENSED SERVICES related to such LICENSED PRODUCTS or that are in process, subject to the terms of this Agreement (including without limitation the obligation to pay royalties under Article 4 ), provided that LICENSEE shall complete and sell all such work-in-progress and inventory within six (6) months after the effective date of termination.
9.5 Upon the expiration of the TERM of this Agreement LICENSEE shall have a fully paid-up, non-exclusive, irrevocable, royalty free license under the rights granted in Article 2 .
9.6 Nothing herein shall be construed to release either Party from any obligation that accrued prior to expiration or any termination of this Agreement. The following provisions shall survive any termination or any expiration of the TERM of this Agreement: this Section 9.6 and Articles/Sections 1, 4, 5, 8, 9.4, 10, 11, 12, 13, 15.1, 15.2, 15.5, 15.6, 15.7, 15.8, 15.10, 15.15 and 15.16 , and any other provision which by its nature is intended to survive any such termination.

 

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ARTICLE 10 — CONFIDENTIALITY AND NON-DISCLOSURE
10.1 Confidential Information; Non-Disclosure . “Confidential Information” shall mean any technical, business, financial, customer or other information disclosed by one Party (the “Disclosing Party”) to the other Party (the “Receiving Party”) pursuant to this Agreement which is marked “Confidential” or “Proprietary,” or which, under all of the given circumstances, ought reasonably to be treated as confidential information of the Disclosing Party. Such information may be disclosed in oral, visual or written form (including magnetic, optical or other media). Except as expressly provided in Section 10.2 below, each Party’s Confidential Information specifically includes without limitation the respective Party’s business plans and business practices, the terms of this Agreement, scientific knowledge, research and development or know-how, processes, inventions, techniques, formulae, products and product plans, business operations, customer requirements, designs, sketches, photographs, drawings, specifications, reports, studies, findings, data, plans or other records, biological materials, software, margins, payment terms and sales forecasts, volumes and activities, designs, computer code, technical information, costs, pricing, financing, business opportunities, personnel, and information of LICENSOR or LICENSEE relating to the LICENSED PROCESSES, LICENSED PRODUCTS or LICENSED SERVICES whether or not such information is marked or identified provided that the Disclosing Party provides notice in writing reasonably identifying such Confidential Information within 30 days of disclosure. Except to the extent expressly authorized by this Agreement or by other prior written consent by the Disclosing Party, the Receiving Party, during the term of this Agreement, and thereafter, shall: (i) treat as confidential all Confidential Information of the other Party; (ii) use Confidential Information only for exercising the rights and fulfilling the obligations set forth in this Agreement, (iii) implement reasonable procedures to prohibit the disclosure, unauthorized duplication, misuse or removal of the Disclosing Party’s Confidential Information; (iv) not disclose Confidential Information to any third party, and (v) only disclose the Confidential Information to (a) those of its employees who have a need to know Confidential Information in order to exercise the rights and fulfill the obligations set forth in this Agreement and (b) legal and professional advisors and existing and potential investors and their legal and professional advisors, each of which is bound by a written agreement (or in the case of attorneys or other professional advisors, formal ethical duties) requiring such advisors and investors to treat, hold and maintain such Confidential Information in accordance with the terms and conditions of this Agreement, or (c) recipients of offering documents in connection with any offering of securities where such disclosure is, in the opinion of counsel for the Disclosing Party, reasonably required to comply with the investment disclosure laws of any applicable jurisdiction. Without limiting the foregoing, the Receiving Party shall protect the Disclosing Party’s Confidential Information using at least the same procedures and degree of care that it uses to prevent the disclosure of its own confidential information of like importance, but in no event less than reasonable care.

 

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10.2 Exceptions . The Receiving Party shall have no obligation or liability to the Disclosing Party with regard to any Confidential Information of the Disclosing Party: (i) that was publicly known and available at the time it was disclosed or becomes publicly known and available through no fault, action, or inaction of the Receiving Party; (ii) was known to the Receiving Party, without restriction, at the time of disclosure as shown by the files of the Receiving Party in existence at the time of disclosure; (iii) is disclosed with the prior written approval of the Disclosing Party; (iv) was independently developed by the Receiving Party without any use of the disclosing party’s Confidential Information, provided, that the Receiving Party can demonstrate such independent development by documented evidence prepared contemporaneously with such independent development; (v) is disclosed pursuant to the order or requirement of a court, administrative agency, or other governmental body, provided that the Receiving Party shall provide prompt notice thereof and reasonable assistance to the Disclosing Party to enable the Disclosing Party to seek a protective order or otherwise prevent such disclosure, and provided further that such disclosure is limited to the extent necessary to comply with such order and the information shall otherwise be treated as Confidential Information; or (vi) that is provided to the Receiving Party by an independent third party without violating any confidentiality obligation to the Disclosing Party.
10.3 Injunctive Relief . LICENSOR and LICENSEE acknowledge and agree that any breach of the confidentiality obligations imposed by this Article 10 will constitute immediate and irreparable harm to the Disclosing Party and/or its successors and assigns, which cannot adequately and fully be compensated by money damages and will warrant, in addition to all other rights and remedies afforded by law, injunctive relief, specific performance, and/or other equitable relief. The Disclosing Party’s rights and remedies hereunder are cumulative and not exclusive. The Disclosing Party shall also be entitled to receive from the Receiving Party the costs of enforcing this Article 10 , including reasonable attorneys’ fees and expenses of litigation.
10.4 Termination . Upon termination or expiration of this Agreement, or upon the request of the Disclosing Party at any time, the Receiving Party shall promptly return to the Disclosing Party, at its request, all copies of Confidential Information received from the Disclosing Party, and shall return or destroy, and document the destruction of, all summaries, abstracts, extracts, or other documents which contain any Confidential Information of the Disclosing Party in any form. Notwithstanding the foregoing to the contrary, LICENSEE shall have no obligation (even upon a request by LICENSOR) to return or destroy any KNOW-HOW (including tangible embodiments of KNOW-HOW) during the TERM of this Agreement.
10.5 Survival . The obligations of LICENSOR and LICENSEE under this Article 10 shall survive any expiration or termination of this Agreement.
ARTICLE 11 — PAYMENTS, NOTICES, AND OTHER COMMUNICATIONS
Any payment, notice or other communication pursuant to this Agreement shall be in writing and sent by certified first class mail, postage prepaid, return receipt requested, or by nationally recognized overnight carrier addressed to the Parties at the following addresses or such other addresses as such Party furnishes to the other Party in accordance with this paragraph. Such notices, payments, or other communications shall be effective upon receipt.

 

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In the case of LICENSOR:
Advanced Cell Technology, Inc.
One Innovation Drive
Worcester, MA 01605
Attention: Michael D. West, Ph.D., President
With a copy to:
Pierce Atwood
One Monument Square
Portland, ME 04101
Attention: William L. Worden, Esq.
In the case of LICENSEE:
PacGen Cellco, LLC.
157 Surfview Drive
Pacific Palisades, CA 90272
Attention: Kenneth Aldrich
With a copy to:
Gray Cary Ware & Freidenrich
4365 Executive Drive, Suite 1100
San Diego, CA 92121-2133
Attention: Lisa Haile
ARTICLE 12 — RESPRESENTATIONS AND WARRANTIES OF LICENSOR
As an inducement to LICENSEE to enter into and perform this Agreement, LICENSOR represents and warrants to LICENSEE as follows:
12.1 Title to LICENSED TECHNOLOGY; Encumbrances . LICENSOR has good and valid title or valid licenses (with the right of sublicense) to the LICENSED TECHNOLOGY.
12.2 No Violations . The execution, delivery and performance of this Agreement by LICENSOR and the consummation by LICENSOR of the transactions contemplated hereby does not,: (a) violate any statute, ordinance, rule or regulation applicable to LICENSOR or by which any of the LICENSED TECHNOLOGY may be bound; (b) violate any order, judgment or decree of any court or of any Governmental Authority or regulatory body, agency or authority applicable to LICENSOR or by which any of the LICENSED TECHNOLOGY may be bound; (c) require any filing by LICENSOR with, or require LICENSOR to obtain any permit, consent or approval of, or require LICENSOR to give any notice to, any Governmental Authority or regulatory body, agency or authority; or (d) result in a violation or breach by LICENSOR of, conflict with, constitute a default by LICENSOR (or give rise to any right of termination, cancellation, payment or acceleration) under or result in the creation of any Encumbrance upon any of the LICENSED TECHNOLOGY.

 

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12.3 Litigation . Except as set forth in Exhibit C, there is no action, suit, proceeding at law or in equity, arbitration or administrative or other proceeding by or before (or any investigation by) any governmental or other instrumentality or agency, pending, or threatened, against or affecting the LICENSED TECHNOLOGY, and LICENSOR does not know of any valid basis for any such action, proceeding or investigation. To the knowledge of LICENSOR, there are no such suits, actions, claims, proceedings or investigations pending or threatened, seeking to prevent or challenge the transactions contemplated by this Agreement.
12.4 Disclosure . Neither these representations and warranties made by LICENSOR pursuant to this Agreement nor any of the exhibits, schedules or certificates attached hereto or delivered in accordance with the terms hereof knowingly contains any misstatement of fact or omits any statement of fact necessary in order to make the statements contained herein and therein not misleading in light of the circumstances under which they were made.
12.5 Copies of Documents . LICENSOR has caused to be made available for inspection and copying by LICENSEE and its advisers, true, complete and correct copies of all documents in LICENSOR’s possession referred to in any schedule attached hereto.
12.6 Broker’s or Finder’s Fees . No agent, broker, person or firm acting on behalf of LICENSOR is, or will be, entitled to any fee, commission or broker’s or finder’s fees for which the LICENSEE may be liable in connection with this Agreement or any of the transactions contemplated hereby.
12.7 LICENSED TECHNOLOGY .
  (a)   Except as set forth on Exhibit D, LICENSOR, LICENSOR is not aware of any interference, infringement, misappropriation, or other conflict with any intellectual property rights of third parties, and LICENSOR has never received any charge, complaint, claim, demand, or notice alleging any such interference, infringement, misappropriation, or violation (including any claim that LICENSOR must license or refrain from using any intellectual property rights of any third party). To the knowledge of LICENSOR, no third party has interfered with, infringed upon, misappropriated, or otherwise come into conflict with any of the LICENSED TECHNOLOGY.
 
  (b)   Exhibit A identifies each patent or registration which has been issued to LICENSOR with respect to any of the LICENSED TECHNOLOGY and identifies each pending patent application or application for registration which LICENSOR has made with respect to any of the LICENSED

 

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      TECHNOLOGY. LICENSOR has made available to LICENSEE correct and complete copies of all such patents, registrations and applications (as amended to-date) in LICENSOR’s possession and has made available to LICENSEE correct and complete copies of all other written documentation in LICENSOR’s possession evidencing ownership and prosecution (if applicable) of each such item.
  (c)   Exhibit A identifies each item of LICENSED TECHNOLOGY that is assigned to LICENSOR or that LICENSOR uses pursuant to license, sublicense, agreement, or permission. LICENSOR has made available to LICENSEE correct and complete copies of all such licenses, sublicenses, agreements, patent prosecution files and permissions (as amended to-date) in LICENSOR’s possession. With respect to each item of LICENSED TECHNOLOGY required to be identified in Exhibit A and to the knowledge of LICENSOR: (i) the license, sublicense, agreement, or permission covering the item is legal, valid, binding, enforceable, and in full force and effect; (ii) the license, sublicense, agreement, or permission will continue to be legal, valid, binding, enforceable, and in full force and effect on identical terms following the consummation of the transactions contemplated hereby; (iii) no Party to the license, sublicense, agreement, or permission is in breach or default, and no event has occurred which with notice or lapse of time would constitute a breach or default or permit termination, modification, or acceleration thereunder; (iv) no party to the license, sublicense, agreement, or permission has repudiated any provision thereof; (v) the underlying item of LICENSED TECHNOLOGY is not subject to any outstanding lien or encumbrance, injunction, judgment, order, decree, ruling, or charge; (vi) no action, suit, proceeding, hearing, investigation, charge, complaint, claim, or demand is pending or is threatened which challenges the legality, validity, or enforceability of the underlying item of LICENSED TECHNOLOGY; and (vii) LICENSOR has not granted any sublicense or similar right to the LICENSED TECHNOLOGY within the FIELD.
12.8 Survival of Representations and Warranties .
  (a)   Except as otherwise provided herein, notwithstanding any investigation at any time made by or on behalf of any Party hereto, the representations and warranties set forth herein and in any certificate delivered in connection herewith with respect to any of those representations and warranties will survive the Effective Date until the longer to occur of: (i) two (2) years or (ii) the expiration of the applicable statutes of limitation, including all periods of extension and tolling whereupon they will terminate and expire.

 

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  (b)   After a representation and warranty has expired, as provided in Subsection 12.8(a) , no claim for claims or costs may be made or prosecuted by any Person who would have been entitled to claims or costs on the basis of that representation and warranty prior to its termination and expiration, provided that no claim presented in writing for claims or costs to the Person or Persons from which or whom those damages are sought on the basis of that representation and warranty prior to its termination and expiration will be affected in any way by that termination and expiration.
12.9 EXCEPT AS OTHERWISE EXPRESSLY SET FORTH IN THIS AGREEMENT, LICENSOR, ITS DIRECTORS, OFFICERS, EMPLOYEES, AND AFFILIATES MAKE NO REPRESENTATIONS AND EXTEND NO WARRANTIES OF ANY KIND, EITHER EXPRESS OR IMPLIED, INCLUDING BUT NOT LIMITED TO WARRANTIES OF MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE, VALIDITY OF PATENT RIGHTS, ISSUED OR PENDING, AND THE ABSENCE OF LATENT OR OTHER DEFECTS, WHETHER OR NOT DISCOVERABLE. NOTHING IN THIS AGREEMENT SHALL BE CONSTRUED AS A REPRESENTATION MADE OR WARRANTY GIVEN BY LICENSOR THAT THE PRACTICE BY LICENSEE OF THE LICENSE GRANTED HEREUNDER SHALL NOT INFRINGE THE PATENT RIGHTS OF ANY THIRD PARTY.
ARTICLE 13—REPRESENTATIONS AND WARRANTIES OF LICENSEE.
LICENSEE represents and warrants to LICENSOR as follows:
13.1 Existence and Good Standing: Power and Authority . LICENSEE is a limited liability company duly organized, validly existing and in good standing under the laws of the state of California. LICENSEE has full corporate power and authority to make, execute, deliver and perform this Agreement, to perform its obligations hereunder and to consummate the transactions contemplated hereby. The execution, delivery and performance of this Agreement by LICENSEE and the consummation by it of the transactions contemplated hereby, have been duly authorized and approved by all required corporate action of LICENSEE and no other action on the part of LICENSEE is necessary to authorize the execution, delivery and performance of this Agreement by LICENSEE and the consummation of the transaction contemplated hereby. This Agreement has been duly executed and delivered by LICENSEE and is a valid and binding obligation of LICENSEE enforceable against it in accordance with its terms, except to the extent that its enforceability may be subject to applicable bankruptcy, insolvency, reorganization, moratorium and similar laws affecting the enforcement of creditors’ rights generally and by general equitable principles.
13.2 Authorization and Validity of Agreement . LICENSEE has full power and authority, including full corporate power and authority, to execute and deliver this Agreement, to perform its obligations hereunder and to consummate the transactions contemplated hereby.

 

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Without limiting the foregoing, the execution, delivery and performance of this Agreement by LICENSEE and the consummation by it of the transactions contemplated hereby, have been duly authorized and approved by the members and managers of LICENSEE, and no other action on the part of LICENSEE or its officers, directors or shareholder is necessary to authorize the execution, delivery and performance of this Agreement by LICENSEE and the consummation of the transactions contemplated hereby. This Agreement has been duly executed and delivered by LICENSEE and is a valid and binding obligation of LICENSEE enforceable against it in accordance with its terms, except to the extent that its enforceability may be subject to applicable bankruptcy, insolvency, reorganization, moratorium and similar laws affecting the enforcement of creditors’ rights generally and by general equitable principles.
13.3 Consents and Approvals; No Violations . The execution, delivery and performance of this Agreement by LICENSEE and the consummation by LICENSEE of the transactions contemplated hereby will not, with or without the giving of notice or the lapse of time or both: (a) violate, conflict with, or result in a breach or default under any provision of the organizational documents of LICENSEE; (b) violate any statute, ordinance, rule or regulation applicable to LICENSEE, (c) violate any order, judgment or decree of any court or of any governmental or regulatory body, agency or authority applicable to LICENSEE or by which any of the LICENSED TECHNOLOGY may be bound; or (d) require any filing by LICENSEE with, or require LICENSEE to obtain any permit, consent or approval of, or require LICENSEE to give any notice to, any governmental or regulatory body, agency or authority, except filings, if any, which may be required under the “Blue Sky” laws of Massachusetts or as may be required in the future to comply with governmental regulations governing the production and sale of products by LICENSEE as it conducts its business.
13.4 Survival of Representations and Warranties .
  (a)   Except as otherwise provided herein, notwithstanding any investigation at any time made by or on behalf of any Party hereto, the representations and warranties set forth herein and in any certificate delivered in connection herewith with respect to any of those representations and warranties will survive the Effective Date until the longer to occur of: (i) two (2) years or (ii) the expiration of the applicable statutes of limitation, including all periods of extension and tolling whereupon they will terminate and expire.
 
  (b)   After a representation and warranty has expired, as provided in Subsection 13.4(a) , no claim for claims or costs may be made or prosecuted by any Person who would have been entitled to claims or costs on the basis of that representation and warranty prior to its termination and expiration, provided that no claim presented in writing for claims or costs to the Person or Persons from which or whom those damages are sought on the basis of that representation and warranty prior to its termination and expiration will be affected in any way by that termination and expiration.

 

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ARTICLE 14 — LIMITATION OF LIABILITY
EXCEPT FOR ANY LIABILITY TO ANY THIRD PARTIES PURSUANT TO ARTICLE 8 OR TO A PARTY PURSUANT TO ARTICLES 12 AND 13 OF THIS AGREEMENT, IN NO EVENT SHALL LICENSOR OR LICENSEE OR THEIR, ITS DIRECTORS, OFFICERS, EMPLOYEES OR AFFILIATES BE LIABLE FOR INCIDENTAL OR CONSEQUENTIAL DAMAGES OF ANY KIND, INCLUDING ECONOMIC DAMAGE OR INJURY TO PROPERTY AND LOST PROFITS, REGARDLESS OF WHETHER LICENSOR OR LICENSEE SHALL BE ADVISED, SHALL HAVE OTHER REASON TO KNOW, OR IN FACT SHALL KNOW OF THE POSSIBILITY OF SUCH DAMAGES.
ARTICLE 15 — MISCELLANEOUS PROVISIONS
15.1 CORPORATE PARTNERSHIPS. In the event LICENSEE enters into a corporate partnership for the joint development of any of the LICENSED TECHNOLOGY, and LICENSEE sublicenses the LICENSED TECHNOLOGY to a third party, then payments required hereunder shall not include funds provided for sponsored research or equity investments by any third party so long as such payments do not constitute a majority of funds transferred by such third party. However if the sponsored research involves fees in excess of industry standard reimbursement for FTEs or any equity investment in excess of fair market value, LICENSEE shall pay to LICENSOR a royalty on such excess fees calculated at the rates specified herein.
15.2 LICENSEE “REVERSE LICENSE” TO LICENSOR. LICENSEE agrees to license to LICENSOR on a non-exclusive basis for therapeutic uses in the treatment of blood and cardiovascular diseases the rights to any technology it currently owns or has licensed or develops or licenses in the future that is applicable to such diseases (excluding however the use of proprietary techniques now or hereafter developed by LICENSEE for the enhanced vascularization of transplanted cells or tissues). Such license shall provide for royalty payments at the same rate as LICENSEE’S royalty payments to LICENSOR hereunder as provided in Section 4.2(a). Such license will be sublicensable only once in a given field of use; or for the purpose of having products produced, made, or distributed; or in connection with a merger or consolidation of LICENSOR into another company or a sale of all or substantially all of the assets of LICENSOR. LICENSEE shall also have no obligations hereunder with respect to technology licenses it has or may acquire if such licenses restrict sublicensing in a manner inconsistent with this subparagraph. Such “Reverse License shall not apply to any rights acquired by LICENSEE under Section 15.18 hereof.

 

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15.3 FUTURE TECHNOLOGY LICENSES. LICENSOR acknowledges that it is continuing to develop cell-based technology, the existence or significance of which it may not have disclosed to LICENSEE. Therefore, LICENSOR further agrees that in the event any of its technology now perfected or pending as of the date of this agreement but not specifically enumerated herein would inhibit or adversely affect the commercial use by LICENSEE of the PATENT RIGHTS in the field, LICENSOR shall waive any claim of infringement to the extent necessary to permit LICENSEE to continue the use of the PATENT RIGHTS under this Agreement. In addition, LICENSOR agrees to license to LICENSEE on a non-exclusive basis for uses in the FIELDS, including any rights acquired under Section 15.18 hereof, the rights to any technology it currently owns or has licensed or develops or licenses in the future that is applicable to such FIELDS (but specifically excluding applications involving the use of cells in the treatment of tumors where the primary use of the cells is the destruction or reduction of tumors and does not involve regeneration of tissue or organ function). Such license shall provide for royalty payments at the same rate as LICENSEE’S royalty to LICENSOR hereunder as provided in Section 4.2(a). Such license will be sublicensable only once in a given field of use; or for the purpose of having products produced, made, or distributed; or in connection with a merger or consolidation of LICENSEE into another company or a sale of all or substantially all of the assets of LICENSEE. LICENSOR shall also have no obligations hereunder with respect to technology licenses it has or may acquire if such licenses restrict sublicensing in a manner inconsistent with this subparagraph.
15.4 LICENSEE shall comply with all local, state, federal and international laws and regulations relating to the development, manufacture, use, provision, and sale of LICENSED PRODUCTS, LICENSED PROCESSES and LICENSED SERVICES. Without limiting the generality of the foregoing, LICENSEE agrees to comply with the following:
  a)   LICENSEE shall obtain all necessary approvals from the FDA, USDA, or any similar governmental authorities of any foreign jurisdiction in which LICENSEE intends to make, use, or sell LICENSED PRODUCTS or to perform LICENSED PROCESSES or LICENSED SERVICES.
 
  b)   LICENSEE shall comply fully with any and all applicable local, state, federal and international laws and regulations relating to the LICENSED PRODUCTS, LICENSED PROCESSES and LICENSED SERVICES, and the PATENT RIGHTS, in the TERRITORY, including without limitation all export or import regulations and rules now in effect or as may be issued from time to time by any governmental authority which has jurisdiction relating to the export of LICENSED PRODUCTS, LICENSED PROCESSES or LICENSED SERVICES and any technology relating thereto. LICENSEE hereby gives written assurance that it will comply with all such import or export laws and regulations (including without limitation all Export Administration Regulations of the United States Department of Commerce), that it bears sole responsibility for any violation of such laws and regulations, and that it will indemnify, defend, and hold LICENSOR harmless (in accordance with Article 8 ) for the consequences of any such violation.

 

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  c)   To the extent that any invention claimed in the PATENT RIGHTS has been partially funded by the United States Government, and only to the extent required by applicable laws and regulations, LICENSEE agrees that any LICENSED PRODUCTS used or sold in the United States will be manufactured substantially in the United States or its territories. Current law provides that if a domestic manufacturer is not commercially feasible under the circumstances, LICENSOR may seek a waiver of this requirement from the relevant federal agency on behalf of LICENSEE and, upon LICENSEE’S request, shall cooperate with LICENSEE in seeking such a waiver.
15.5 LICENSEE shall not create or incur or cause to be incurred or to exist any lien, encumbrance, pledge, charge, restriction or other security interest of any kind upon the PATENT RIGHTS, but may cause to be incurred or to exist a lien, encumbrance, pledge, charge, restriction or other security interest on its rights to the LICENSED TECHNOLOGY hereunder, provided such security interest does not affect LICENSOR’s rights to the LICENSED TECHNOLOGY, or any of LICENSOR’s rights under this Agreement.
15.6 Neither Party shall originate any publicity, news release or other public announcement (“Announcements”), written or oral, relating to this Agreement or the existence of an arrangement between the Parties, without the prior written approval of the other Party, which approval shall not be unreasonably withheld or delayed, except as otherwise required by law. The foregoing notwithstanding, LICENSOR and LICENSEE shall have the right to make such Announcements without the consent of the other Party in any prospectus, offering memorandum, or other document or filing required by applicable securities laws or other applicable law or regulation, provided that such Party shall have given the other Party at least ten (10) days prior written notice of the proposed text for the purpose of giving the other Party the opportunity to comment on such text.
15.7 No implied licenses are granted pursuant to the terms of this Agreement. No licensed rights shall be created by implication or estoppel.
15.8 Nothing herein shall be deemed to constitute either Party as the agent or representative of the Party, or both parties as joint venturers or partners for any purpose. Each Party shall be an independent contractor, not an employee or partner of the other Party, and the manner in which each Party renders its services under this Agreement shall be within its sole discretion. Neither Party shall be responsible for the acts or omissions of the other Party, nor shall either Party have authority to speak for, represent or obligate the other Party in any way without prior written authority from the other Party.
15.9 To the extent commercially feasible, and consistent with prevailing business practices and applicable law, all LICENSED PRODUCTS sold pursuant to this Agreement will be marked with the number of each issued patent that applies to such LICENSED PRODUCTS.

 

23


 

15.10 This Agreement shall be construed, governed, interpreted and applied in accordance with the laws of the State of California, U.S.A. without regard to principles of conflicts of law thereof, except that questions affecting the construction and effect of any patent shall be determined by the law of the country in which the patent was granted.
15.11 The Parties hereto acknowledge that this Agreement sets forth the entire Agreement and understanding of the Parties hereto as to the subject matter hereof, and shall not be subject to any change or modification except by the execution of a written instrument signed by the Parties hereto.
15.12 The provisions of this Agreement are severable, and in the event that any provision of this Agreement shall be determined to be invalid or unenforceable under any controlling body of the law, such invalidity or unenforceability shall not in any way affect the validity or enforceability of the remaining provisions hereof.
15.13 The failure of either Party to assert a right hereunder or to insist upon compliance with any term or condition of this Agreement shall not constitute a waiver of that right or excuse a similar subsequent failure to perform any such term or condition by the other Party.
15.14 This Agreement may not be assigned by LICENSEE without the prior written consent of LICENSOR, which consent shall be granted or denied in LICENSOR’s sole discretion. LICENSOR may not assign this Agreement without the consent of LICENSEE, which consent shall not be unreasonably withheld or delayed, except that LICENSOR may assign this Agreement to an affiliate or to a successor in connection with the merger, consolidation, or sale of all or substantially all of its assets or that portion of its business to which this Agreement relates. Notwithstanding the foregoing to the contrary, this restriction on the assignment by LICENSEE of this Agreement shall not prevent the assignment of this Agreement in connection with a merger or consolidation of LICENSEE into another company or a sale of all or substantially all of the assets of LICENSEE, so long as the purchaser of the assets agrees to assume to any and all outstanding liabilities to LICENSOR under this Agreement, including but not limited to any outstanding amounts under the promissory note referred to in Section 4.1 .
15.15 This Agreement has been prepared jointly and no rule of strict construction shall be applied against either Party. In this Agreement, the singular shall include the plural and vice versa and the word “including” shall be deemed to be followed by the phrase “without limitation.” The section headings contained in this Agreement are inserted for convenience only and shall not affect in any way the meaning or interpretation of this Agreement.
15.16 This Agreement may be executed in counterparts, each of which together shall constitute one and the same Agreement.

 

24


 

15.17 All rights and licenses granted under or pursuant to this Agreement by LICENSOR to LICENSEE are, and shall otherwise be deemed to be, for purposes of Paragraph 365(n) of the U.S. Bankruptcy Code (the “Code”), licenses to rights in “intellectual property” as defined in the Code. The Parties hereto agree that LICENSEE, as a LICENSEE of such rights under this Agreement, shall retain and may fully exercise all of its rights and elections under the Code. The Parties hereto further agree that, in the event of the commencement of a bankruptcy proceeding by or against LICENSOR including a proceeding under the Code, LICENSEE shall be entitled to a complete duplicate of (or complete access to, as appropriate) any such intellectual property and all embodiments of such intellectual property, including the PATENT RIGHTS and KNOW-HOW, and the same, if not already in LICENSEE’s possession, shall be promptly delivered to LICENSEE upon any such commencement of a bankruptcy proceeding upon written request therefore by LICENSEE.
15.18 In addition to the other rights granted herein, LICENSOR hereby grants to LICENSEE a 90 day right of negotiation with respect to any technology that would constitute LICENSED TECHNOLOGY if the FIELD included diseases related either to the heart or to neuro degenerative diseases (the “Added Fields”) prior to LICENSOR entering into any license relating to either of such Added Fields) with a third party. Such a 90 day period shall commence on the earlier of the 12 month anniversary of the Effective Date, or such date when LICENSOR notifies LICENSEE that it has opened negotiations with a third party or that a third party has made inquiry about such a license. If following the expiration of any such 90-day negotiation period LICENSEE and LICENSOR have not entered into a license for an Added Field, LICENSOR shall be free to enter into an exclusive or non-exclusive license for such Added Field with any third party. If LICENSOR enters into a non-exclusive license for an Added Field with a third party following the 90-day negotiating period hereunder, LICENSOR shall offer a non-exclusive license to LICENSEE on comparable terms as those entered into with such third party. LICENSEE shall then have 30 days to enter into such a nonexclusive license. If LICENSEE does not enter into such a license within said 30-day period, LICENSOR shall have no further obligations relating to the Added Field.
[Remainder of this page intentionally left blank]

 

25


 

IN WITNESS WHEREOF, the Parties have duly executed this Agreement on the EFFECTIVE DATE.
ADVANCED CELL TECHNOLOGY, INC.
         
By:
       
 
       
Printed Name: Michael D. West, Ph.D.    
Title: President & Chief Executive Officer    
PACGEN CELLCO, LLC
         
By:
       
 
       
Printed Name: Kenneth Aldrich    
Title: Managing Member    

 

 


 

EXHIBIT A
PATENT RIGHTS
(Reference Section 1.10)
                 
Serial No.       Filing Date        
Patent No.   CO   Issue Date   Title   Assignee
60/382,616
  US   2002-05-24   A Bank of Nuclear Transfer-Generated Stem Cells for Transplantation Having Homozygous MHC Alleles, and Methods for Making and Using Such a Stem Cell Bank   ACT, Inc.
 
               
10/445,195
  US   2003-05-27   A Bank of Nuclear Transfer-Generated Stem Cells for Transplantation Having Homozygous MHC Alleles, and Methods for Making and Using Such a Stem Cell Bank   ACT, Inc.
 
               
PCT/US03/16626
  WO   2003-05-27   A Bank of Nuclear Transfer-Generated Stem Cells for Transplantation Having Homozygous MHC Alleles, and Methods for Making and Using Such a Stem Cell Bank   ACT, Inc.
 
               
PCT/US00/18063
  WO   2000-06-30   Cytoplasmic Transfer to De-Differentiate Recipient Cells   ACT, Inc.
 
               
60/141,250
  US   1999-06-30   Cytoplasmic Transfer to De-Differentiate Recipient Cells   ACT, Inc.
 
               
09/736,268
  US   2000-12-15   Cytoplasmic Transfer to De-Differentiate Recipient Cells   ACT, Inc.
 
               
516236
  NZ   2000-06-30   Cytoplasmic Transfer to De-Differentiate Recipient Cells   ACT, Inc.
 
               
2000000507057
  JP   2000-06-30   Cytoplasmic Transfer to De-Differentiate Recipient Cells   ACT, Inc.
 
               
147179
  IL   2000-06-30   Cytoplasmic Transfer to De-Differentiate Recipient Cells   ACT, Inc.
 
               
2000000008098
  CN   2000-06-30   Cytoplasmic Transfer to De-Differentiate Recipient Cells   ACT, Inc.
 
               
2,377,515
  CA   2000-06-30   Cytoplasmic Transfer to De-Differentiate Recipient Cells   ACT, Inc.
 
               
PI0012099-5
  BR   2000-06-30   Cytoplasmic Transfer to De-Differentiate Recipient Cells   ACT, Inc.
 
               
2000000059028
  AU   2000-06-30   Cytoplasmic Transfer to De-Differentiate Recipient Cells   ACT, Inc.

 

2


 

                 
Serial No.       Filing Date        
Patent No.   CO   Issue Date   Title   Assignee
PCT/US02/26798
  WO   2002-08-27   Dedifferentiation and Re-Differentiation of Somatic Cells and Production of Cells for Cell Therapies   ACT, Inc.
 
               
10/228,316
  US   2002-08-27   Dedifferentiation and Re-Differentiation of Somatic Cells and Production of Cells for Cell Therapies   ACT, Inc.
 
               
60/314,657
  US   2001-08-27   Dedifferentiation of Somatic Cells and Use for Cell Therapies   ACT, Inc.
 
               
60/382,386
  US   2002-05-23   Generation of Histocompatible Tissues Using Nuclear Transplantation   ACT, Inc.
 
               
PCT/US03/16424
  US   2003-05-23   Generation of Histocompatible Tissues Using Nuclear Transplantation   ACT, Inc.
 
               
60/342,358
  US   2001-12-27   Generation of Human Stem Cells Via Cross Species Nuclear Transfer   ACT, Inc.
 
               
PCT/US02/41572
  WO   2002-12-27   Embryonic or Stem-Like Cell Lines Produced by Cross Species Nuclear Transplantation and Method for Enhancing Embryonic Development by Genetic Alteration of Donor Cells or by Tissue Culture Conditions   ACT, Inc.
 
               
60/332,510
  US   2001-11-26   Human Nuclear Transfer   ACT, Inc.
 
               
PCT/US02/37899
  WO   2002-11-26   Methods for Making and Using Reprogrammed Human Somatic Cell Nuclei and Autologous and Isogenic Human Stem Cells   ACT, Inc.
 
               
10/304,020
  US   2002-11-26   Methods for Making and Using Reprogrammed Human Somatic Cell Nuclei and Autologous and Isogenic Human Stem Cells   ACT, Inc.
 
               
10/484,398
  US   2002-07-18   Improved Methods and Compositions for Cell Therapy   ACT, Inc.
 
               
02322522
  AU   2002-07-18   Improved Methods and Compositions for Cell Therapy   ACT, Inc.
 
               
PCT/US02/22857
  WO   2002-07-18   Improved Methods and Compositions for Cell Therapy   ACT, Inc.
 
               
60/305,904
  US   2001-07-18   Improved Methods and Compositions for Cell Therapy   ACT, Inc.

 

3


 

                 
Serial No.       Filing Date        
Patent No.   CO   Issue Date   Title   Assignee
60/280,138
  US   2001-04-02   Method for Facilitating the Production of Differentiated Cell Types and Tissues from Embryonic and Adult Pluripotent and Multipotent Cells   ACT, Inc.
 
               
10/112,939
  US   2002-04-02   Method for Facilitating the Production of Differentiated Cell Types and Tissues from Embryonic and Adult Pluripotent and Multipotent Cells   ACT, Inc.
 
               
PCT/US00/24398
  WO   2000-09-06   Method for Generating Immune-Compatible Cells and Tissues Using Nuclear Transfer Techniques   ACT, Inc.
 
               
09/655,815
  US   2000-09-06   Method for Generating Immune-Compatible Cells and Tissues Using Nuclear Transfer Techniques   ACT, Inc.
 
               
60/152,354
  US   1999-09-07   Method for Generating Immune-Compatible Cells and Tissues Using Nuclear Transfer Techniques   ACT, Inc.
 
               
60/155,107
  US   1999-09-22   Method for Generating Immune-Compatible Cells and Tissues Using Nuclear Transfer Techniques   ACT, Inc.
 
               
09/797,684
  US   2001-03-05   Method for Generating Immune-Compatible Cells and Tissues Using Nuclear Transfer Technique   ACT, Inc.
 
               
PA/a/2002/002444
  MX   2000-09-06   Method for Generating Immune-Compatible Cells and Tissues Using Nuclear Transfer Techniques   ACT, Inc.
 
               
2001-522404
  JP   2000-09-06   Method for Generating Immune-Compatible Cells and Tissues Using Nuclear Transfer Techniques   ACT, Inc.
 
               
148418
  IL   2000-09-06   Method for Generating Immune-Compatible Cells and Tissues Using Nuclear Transfer Techniques   ACT, Inc.

 

4


 

                 
Serial No.       Filing Date        
Patent No.   CO   Issue Date   Title   Assignee
00964946.8
  EP   2000-09-06   Method for Generating Immune-Compatible Cells and Tissues Using Nuclear Transfer Techniques   ACT, Inc.
 
               
CN 00813394.8
  CN   2000-09-06   Method for Generating Immune-Compatible Cells and Tissues Using Nuclear Transfer Techniques   ACT, Inc.
 
               
2,383,776
  CA   2000-09-06   Method for Generating Immune-Compatible Cells and Tissues Using Nuclear Transfer Techniques   ACT, Inc.
 
               
PI0011905-9
  BR   2000-09-06   Method for Generating Immune-Compatible Cells and Tissues Using Nuclear Transfer Techniques   ACT, Inc.
 
               
2000000075755
  AU   2000-09-06   Method for Generating Immune-Compatible Cells and Tissues Using Nuclear Transfer Techniques   ACT, Inc.
 
               
PCT/US00/28285
  WO   2000-10-13   Method of Differentiation of Morula or Inner Cell Mass Cells and Method of Making Lineage-Defective Embryonic Stem Cells   ACT, Inc.
 
               
60/159,550
  US   1999-10-15   Method of Differentiation of Morula or Inner Cell Mass Cells and Method of Making Lineage-Defective Embryonic Stem Cells   ACT, Inc.
 
               
09/689,743
  US   2000-10-13   Method of Differentiation of Morula or Inner Cell Mass Cells and Method of Making Lineage-Defective Embryonic Stem Cells   ACT, Inc.
 
               
518191
  NZ   2000-10-13   Method of Differentiation of Morula or Inner Cell Mass Cells and Method of Making Lineage-Defective Embryonic Stem Cells   ACT, Inc.
 
               
PA/a/2002/003733
  MX   2000-10-13   Method of Differentiation of Morula or Inner Cell Mass Cells and Method of Making Lineage-Defective Embryonic Stem Cells   ACT, Inc.
 
               
2001-532190
  JP   2000-10-13   Method of Differentiation of Morula or Inner Cell Mass Cells and Method of Making Lineage-Defective Embryonic Stem Cells   ACT, Inc.

 

5


 

                 
Serial No.       Filing Date        
Patent No.   CO   Issue Date   Title   Assignee
149043
  IL   2000-10-13   Method of Differentiation of Morula or Inner Cell Mass Cells and Method of Making Lineage-Defective Embryonic Stem Cells   ACT, Inc.
 
               
2000000973497
  EP   2000-10-13   Method of Differentiation of Morula or Inner Cell Mass Cells and Method of Making Lineage-Defective Embryonic Stem Cells   ACT, Inc.
 
               
00817477.6
  CN   2000-10-13   Method of Differentiation of Morula or Inner Cell Mass Cells and Method of Making Lineage-Defective Embryonic Stem Cells   ACT, Inc.
 
               
PI0014864-4
  BR   2000-10-13   Method of Differentiation of Morula or Inner Cell Mass Cells and Method of Making Lineage-Defective Embryonic Stem Cells   ACT, Inc.
 
               
60/152,340
  US   1999-09-07   Methods of Making and Rejuvenating Primary Cells Using Nuclear Transfer   ACT, Inc.
 
               
60/153,233
  US   1999-09-13   Methods of Making and Rejuvenating Primary Cells Using Nuclear Transfer   ACT, Inc.
 
               
2,388,497
  CA   2000-10-13   Methods of Producing Differentiated Progenitor Cells and Lineage-Defective Embryonic Stem Cells   ACT, Inc.
 
               
09/520,879
  US   2000-04-05   Methods of Repairing Tandemly Repeated DNA Sequences and Extending Cell Lifespan Using Nuclear Transfer   ACT, Inc.
 
               
60/539,796
  US   2004-01-28   Novel Culture Systems for Ex
Vivo Development
  ACT, Inc.
 
               
09/656,173
  US   2000-09-06   Telomere Restoration and Extension of Cell Lifespan in Animals Cloned from Senescent Somatic Cells   ACT, Inc.
 
               
09/527,026
  US   2000-03-16   Telomere Restoration and Extension of Cell Lifespan in Animals Cloned from Senescent Somatic Cells   ACT, Inc.
 
               
PCT/US01/12265
  WO   2001-04-16   Pluripotent Cells Comprising Allogenic Nucleus and Mitochrondria   ACT, Inc.

 

6


 

                 
Serial No.       Filing Date        
Patent No.   CO   Issue Date   Title   Assignee
PCT/US03/04868
  WO   2003-02-21   Pluripotent Cells Comprising Allogenic Nucleus and Mitochrondria   ACT, Inc.
 
               
60/197,407
  US   2000-04-14   Pluripotent Cells Comprising Allogenic Nucleus and Mitochrondria   ACT, Inc.
 
               
60/357,854
  US   2002-02-21   Pluripotent Cells Comprising Allogenic Nucleus and Mitochrondria   ACT, Inc.
 
               
NZ 521711
  NZ   2001-04-16   Pluripotent Cells Comprising Allogenic Nucleus and Mitochrondria   ACT, Inc.
 
               
PA/a/2002/010075
  MX   2001-04-16   Pluripotent Cells Comprising Allogenic Nucleus and Mitochrondria   ACT, Inc.
 
               
2001-577429
  JP   2001-04-16   Pluripotent Cells Comprising Allogenic Nucleus and Mitochrondria   ACT, Inc.
 
               
152064
  IL   2001-04-16   Pluripotent Cells Comprising Allogenic Nucleus and Mitochrondria   ACT, Inc.
 
               
EP 00930525
  EP   2001-04-16   Pluripotent Cells Comprising Allogenic Nucleus and Mitochrondria   ACT, Inc.
 
               
CN 01808875.9
  CN   2001-04-16   Pluripotent Cells Comprising Allogenic Nucleus and Mitochrondria   ACT, Inc.
 
               
2,405,555
  CA   2001-04-16   Pluripotent Cells Comprising Allogenic Nucleus and Mitochrondria   ACT, Inc.
 
               
PI0110072-6
  BR   2001-04-16   Pluripotent Cells Comprising Allogenic Nucleus and Mitochrondria   ACT, Inc.
 
               
2001257053
  AU   2001-04-16   Pluripotent Cells Comprising Allogenic Nucleus and Mitochrondria   ACT, Inc.
 
               
PCT/US02/26945
  WO   2002-08-26   Screening Assays for Identifying Differentiation and Antitumor Agents   ACT, Inc.
 
               
60/314,316
  US   2001-08-24   Screening Assays for Identifying Differentiation and Antitumor Agents   ACT, Inc.

 

7


 

                 
Serial No.       Filing Date        
Patent No.   CO   Issue Date   Title   Assignee
10/227,282
  US   2002-08-26   Screening Assays for Identifying Differentiation-Inducing Agents and Production of Differentiated Cells for Cell Therapy   ACT, Inc.
 
               
PCT/US00/24393
  WO   2000-09-06   Telomere Restoration and Extension of Cell Lifespan in Animals Cloned from Senescent Somatic Cells   ACT, Inc.
 
               
60/179,486
  US   2000-02-01   Telomere Restoration and Extension of Cell Lifespan in Animals Cloned from Senescent Somatic Cells   ACT, Inc.
 
               
517577
  NZ   2000-09-06   Telomere Restoration and Extension of Cell Lifespan in Animals Cloned from Senescent Somatic Cells   ACT, Inc.
 
               
PA/a/2002/002443
  MX   2000-09-06   Telomere Restoration and Extension of Cell Lifespan in Animals Cloned from Senescent Somatic Cells   ACT, Inc.
 
               
2001-521771
  JP   2000-09-06   Telomere Restoration and Extension of Cell Lifespan in Animals Cloned from Senescent Somatic Cells   ACT, Inc.
 
               
148457
  IL   2000-09-06   Telomere Restoration and Extension of Cell Lifespan in Animals Cloned from Senescent Somatic Cells   ACT, Inc.
 
               
00961569.1
  EP   2000-09-09   Telomere Restoration and Extension of Cell Lifespan in Animals Cloned from Senescent Somatic Cells   ACT, Inc.
 
               
CN 00813712.9
  CN   2000-09-06   Telomere Restoration and Extension of Cell Lifespan in Animals Cloned from Senescent Somatic Cells   ACT, Inc.
 
               
2,383,790
  CA   2000-09-06   Telomere Restoration and Extension of Cell Lifespan in Animals Cloned from Senescent Somatic Cells   ACT, Inc.
 
               
PI0013844-4
  BR   2000-09-06   Telomere Restoration and Extension of Cell Lifespan in Animals Cloned from Senescent Somatic Cells   ACT, Inc.

 

8


 

                 
Serial No.       Filing Date        
Patent No.   CO   Issue Date   Title   Assignee
73508/00
  AU   2000-09-06   Telomere Restoration and Extension of Cell Lifespan in Animals Cloned from Senescent Somatic Cells   ACT, Inc.
 
               
PCT/US02/27137
  WO   2001-08-27   Transdifferentiation and Re-Differentiation of Somatic Cells and Production of Cells for Cell Therapies   ACT, Inc.
 
               
10/228,296
  US   2002-08-27   Transdifferentiation and Re-Differentiation of Somatic Cells and Production of Cells for Cell Therapies   ACT, Inc.
 
               
60/314,654
  US   2001-08-27   Trans-differentiation of Cells   ACT, Inc.

 

9


 

EXHIBIT B
THIS NOTE AND THE SECURITIES ISSUABLE UPON CONVERSION OF THIS NOTE HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “ACT”), OR UNDER THE SECURITIES LAWS OF APPLICABLE STATES. THESE SECURITIES ARE SUBJECT TO RESTRICTIONS ON TRANSFERABILITY AND RESALE AND MAY NOT BE TRANSFERRED OR RESOLD EXCEPT AS PERMITTED UNDER THE ACT AND THE APPLICABLE STATE SECURITIES LAWS PURSUANT TO REGISTRATION OR EXEMPTION THEREFROM.
FORM OF
CONVERTIBLE PROMISSORY NOTE
OF
PACGEN CELLCO LLC
 
$225,000.00   Made as of May 14, 2004
For value received, PacGen CellCo LLC , a California limited liability company (the “Company”), with principal offices at 157 Surfview Drive, Pacific Palisades, CA 90272, hereby promise to pay to Advanced Cell Technology, Inc., a Delaware corporation (“Holder”), or its registered assigns, the principal sum of Two Hundred Twenty Five Thousand Dollars ($225,000) (the “Principal Amount”).
Unless earlier paid or converted, the unpaid Principal Amount shall be due and payable on June 1, 2007 (the “Maturity Date”). On the Maturity Date, the principal shall be (i) repaid by the Company in cash to the Holder or (ii) at the Holder’s election, converted into shares of Common Stock (as defined below) at the conversion rate set forth in Subsection 2(a) below based on a determination of the Conversion Price as of the Maturity Date made not later than 60 days following the Maturity Date by the Company’s Board of Managers, acting in good faith.
This Note is issued pursuant to that certain Exclusive License Agreement dated as of May 14, 2004 (the “License Agreement”), by and among the Company and Holder, and is subject to the provisions thereof.
The following is a statement of the rights of Holder and the conditions to which this Note is subject, and to which Holder hereof, by the acceptance of this Note, agrees:
  1.   Definitions. The following definitions shall apply for all purposes of this Note:

 

10


 

“Common Stock” means shares of or units of or other interests (as the case may be) of common equity of the Company or its successors or assigns
“Company” means the “Company” as defined above and includes any corporation, which shall succeed to or assume the obligations of the Company under this Note.
“Conversion Price” means (i) in the case of a First Equity Financing, the price paid per share for the equity securities issued in such First Equity Financing; or (ii) in the case of an Acquisition Event (as defined below) the value of one share or unit of Common Stock based upon the portion of the aggregate sale price or merger or consolidation consideration which is available to the Company’s common equity holders in connection with such Acquisition Event; or (iii) on the Maturity, the value of one share or unit of Common Stock as determined in good faith by the Board of Managers.
“First Equity Financing” means a sale or series thereof, subsequent to the date of this Note, by the Company of equity securities in which the Company receives aggregate cash proceeds of at least $5,000,000 (not including conversion of the this Note) as result of investments made by one or more bona fide third party institutional or strategic investors in exchange for the sale of shares of capital stock of the Company.
“Holder” means any person who shall at the time be the registered holder of this Note.
“Maturity Date” means the date on which this Note is either repaid or converted in whole in accordance with the terms hereunder.
“Note” means this Secured Convertible Promissory Note.
“Series A Preferred Stock” means the class of equity securities issued by the Company in the First Equity Financing.
2. Interest .
The principal sum outstanding under this Note shall bear no interest unless not repaid at the Maturity Date, in which event it shall thereafter bear interest at a rate equal to the lesser of (a) ten percent (10%) per annum, or (b) the maximum non-usurious rate allowed under the laws of the State of California.

 

11


 

3. Conversion .
a) Automatic Conversions. This Note shall be automatically converted into that number of shares of Series A Preferred Stock equal to the quotient of (a) the aggregate principal amount of this Note then outstanding divided by (b) the Conversion Price, under the following conditions:
i) Upon the consummation of the First Equity Financing;
ii) Immediately prior to the closing of any merger, sale or other consolidation of the Company or of any sale of all or substantially all assets of the Company which occurs prior to the First Equity Financing (an “Acquisition Event”). Notwithstanding the above, and only in the event that a conversion resulting from such Acquisition Event would result in a security not traded on a national stock exchange (including NASDAQ and NASDAQ small cap), upon written notice to the Company not later than 5 days after the consummation of the Acquisition Event and notice of the Acquisition Event to the Holder of the Note, the Holder may elect to receive payment in cash of the entire outstanding principal of this Note.
b.  Conversion Mechanics . Upon the effective date of any elective or automatic conversion of this Note, the outstanding principal of this Note shall be deemed converted into shares of Series A Preferred Stock or Common Stock automatically as of such effective date without any further action by the Holder and whether or not the Note is surrendered to the Company or its transfer agent. However, the Company shall not be obligated to issue certificates evidencing the shares of the Series A Preferred Stock or Stock issuable upon such elective or automatic conversion unless such Note is either delivered to the Company or its transfer agent, or the Holder notifies the Company or its transfer agent that such Note has been lost, stolen or destroyed and executes an agreement satisfactory to the Company to indemnify the Company from any loss incurred by it in connection with such Note.
4. Reservation of Stock. If at any time the number of shares of Common Stock or other securities issuable upon conversion of this Note shall not be sufficient to effect the conversion of this Note, the Company will take such corporate action as may be necessary to increase its authorized but unissued shares of Common Stock or other securities issuable upon conversion of this Note (and any securities of the Company that the Common Stock may convert into) as shall be sufficient for such purpose.
5. Covenants of the Company. The Company covenants to, and agrees with the Holder that prior to the Maturity Date, so long as the Notes are outstanding, with the following:
a) Organization, Standing Power. The Company is a limited liability company duly organized, validly existing and in good standing under the California Limited Liability Company Act (the “CLLCA”). The Company has all requisite power and authority to conduct its business as now being conducted under the CLLCA.

 

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b) Authority; Enforceability; No Conflict . The Company has all requisite power and authority under the CLLCA to issue this Note and to carry out its obligations hereunder. The issuance of this Note by the Company has been duly and validly authorized by all requisite proceedings on the part of the Company. This Note when executed and delivered by the Company is a valid and binding obligation of the Company, enforceable against the Company in accordance with its terms, except that (i) such enforcement may be subject to bankruptcy, insolvency, reorganization, moratorium, rehabilitation, liquidation, conservatorship, receivership or other similar laws now or hereafter in effect relating to creditors’ rights generally and (ii) the remedy of specific performance and injunctive and other forms of equitable relief may be subject to equitable defenses and to the discretion of the court before which any proceeding therefor may be brought. The execution and delivery of this Note by the Company does not, and the consummation by the Company of the transaction contemplated hereby and thereby will not result in or constitute: (i) a default, breach or violation of or under the limited liability agreement of the Company, (ii) the California Limited Liability Company Act or any applicable law or (iii) any material agreement to which the Company is a party.
6. No Rights or Liabilities as Shareholder. This Note does not by itself entitle the Holder to any voting rights or other rights as a shareholder of the Company. In the absence of conversion of this Note, no provisions of this Note, and no enumeration herein of the rights or privileges of the Holder, shall cause the Holder to be a shareholder of the Company for any purpose.
7. No Impairment. The Company will not, by amendment of its limited liability agreement, or through reorganization, consolidation, merger, dissolution, issue or sale of securities, sale of assets or any other voluntary action, willfully avoid or seek to avoid the observance or performance of any of the terms of this Note, but will at all times in good faith assist in the carrying out of all such terms and in the taking of all such action as may be necessary or appropriate in order to protect the rights of the Holder under this Note against wrongful impairment. Without limiting the generality of the foregoing, the Company will take all such action as may be necessary or appropriate in order that the Company may duly and validly issue fully paid and nonassessable shares of Common Stock upon the conversion of this Note.
8. Prepayment. The Company may at any time, without penalty, prepay in whole or in part the unpaid balance of this Note. All payments will first be applied to the repayment of accrued fees and expenses, if any, then to accrued interest, if any, until all then outstanding accrued interest has been paid, and then shall be applied to the repayment of principal.
9. Notice. The Company shall give the Holder of this Note at least ten (10) days notice of any Acquisition Event.
10. Waiver and Amendment. Any provision of this Note may be amended, waived or modified only upon written consent of the Company and the Holder of the Note.
11. Waiver of Notice and Fees. The Company and all endorsers of this Note hereby waive notice, presentment, protest and notice of dishonor.

 

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12. Transfer. This Note and any rights hereunder may not be assigned, conveyed or transferred, in whole or in part, without the Company’s prior written consent, which consent shall not be unreasonably withheld. The rights and obligations of the Company and the Holder under this Note and the License Agreement shall be binding upon and benefit their respective permitted successors, assigns, heirs, administrators and transferees. However, this Note and the loans evidenced hereby may be transferred in whole or in part only by registration of such transfer on the register maintained for such purpose by or on behalf of the Company.
13. Governing Law. This Note shall be governed by and construed under the internal laws of the State of Delaware, without reference to principles of conflict of laws or choice of laws.
14. Securities Law Representations. This Note is issued to the Holder in reliance upon the Holder’s representation to the Company, which by such Holder’s execution of this Note Holder hereby confirms, that the Note will be acquired for investment for such Holder’s own account, not as a nominee or agent, and not with a view to the sale or distribution of any part thereof, and that such Holder has no present intention of selling, granting any participation in, or otherwise distributing the same. By executing this Note, such Holder further represents that such Holder has no contract, undertaking, agreement or arrangement with any person to sell, transfer, of grant participations to such person or to any third person, with respect to this Note.
15. Headings. The headings and captions used in this Note are used only for convenience and are not to be considered in construing or interpreting this Note. All references in this Note to sections and exhibits shall, unless otherwise provided, refer to sections hereof and exhibits attached hereto, all of which exhibits are incorporated herein by this reference.
16. Severability. If one or more provisions of this Note are held to be unenforceable under applicable law, such provision(s) shall be excluded from this Note and the balance of the Note shall be interpreted as if such provision(s) were so excluded and shall be enforceable in accordance with its terms.
17. Entire Agreement; Successors and Assigns. This Note constitutes the entire contract between the Company and the Holder relative to the subject matter hereof. Any previous agreement between the Company and the Holder is superseded by this Agreement. Subject to the exceptions specifically set forth in this Note, the terms and conditions of this Note shall inure to the benefit of and be binding upon the respective executors, administrators, heirs, successors and assigns of the Parties.
[Remainder of this page intentionally left blank]

 

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IN WITNESS WHEREOF , the Company has caused this Note to be signed in its name as of the date first above written.
PACGEN CELLCO LLC
         
By:
  /S/ KENNETH ALDRICH
 
Name:
   
 
  Title:    
ACCEPTED AND AGREED TO:
ADVANCED CELL TECHNOLOGY, INC.
         
By:
  /S/ MICHAEL D. WEST
 
Name:
   
 
  Title:    

 

 


 

EXHIBIT C
(Reference Section 12.3)
None

 

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EXHIBIT D
(Reference Section 12.7)
None

 

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Exhibit 10.14
EXCLUSIVE LICENSE AGREEMENT (UMass IP)
This Exclusive License Agreement (“Agreement”) is made and entered into this 14 th day of May, 2004 (the “Effective Date”), by and between Advanced Cell Technology, Inc., a Delaware corporation with offices located at One Innovation Drive, Worcester, Massachusetts 01605 (“LICENSOR”), and PacGen Cellco, LLC, a California limited liability company with offices located at 157 Surfview Drive, Pacific Palisades, CA 90272 (“LICENSEE”) (LICENSOR and LICENSEE sometimes hereinafter referred to individually as a “Party” and collectively as the “Parties”).
WITNESSETH
WHEREAS, LICENSOR owns or has licensed with sublicenseable interest the PATENT RIGHTS (as defined below) and KNOW-HOW (as defined below); and
WHEREAS, LICENSEE desires to obtain an exclusive worldwide license under LICENSOR’s rights in such technology in the FIELD; and
WHEREAS, LICENSOR is willing to grant such a license to LICENSEE upon the terms and conditions set forth below; and
NOW, THEREFORE, in consideration of the premises and the mutual covenants contained herein, the Parties hereto agree as follows:
ARTICLE 1 — DEFINITIONS
For the purposes of this Agreement, the following words and phrases shall have the following meanings:
1.1 “ACT ANIMAL CELL LINES” shall mean cell lines of non-human animal origin developed by ACT. These cell lines shall include but not be limited to murine and primate embryonic stem cells derived through parthenogenesis, nuclear transfer or otherwise isolated from fertilized blastocysts including the relevant information LICENSOR possesses associated with these cells, including but not limited to information on the cell’s karyotype, gene expression and growth characteristics.
1.2 “AFFILIATE” shall mean, with respect to any PERSON, any other PERSON which directly or indirectly controls, is controlled by, or is under common control with, such PERSON. A PERSON shall be regarded as in control of another PERSON if it owns, or directly or indirectly controls, at least fifty percent (50%) of the voting stock or other ownership interest of the other PERSON, or if it directly or indirectly possesses the power to direct or cause the direction of the management and policies of the other PERSON by any means whatsoever.

 

 


 

1.3 “FIELD” shall mean (1) the research, development, manufacture and selling of human and non-human animal cells and ACT ANIMAL CELL LINES for commercial research use, including small molecule and other drug testing and basic research, (2) the manufacture and selling of human cells for therapeutic and diagnostic use in the treatment of human (a) diabetes and (b) liver diseases, and (3) the use of ACT ANIMAL CELL LINES in the process of manufacturing and selling human cells for therapeutic and diagnostic use in the treatment of human (a) diabetes and (b) liver diseases but where the final marketed product does not include ACT ANIMAL CELL LINES (i.e. does not include the field of xenotransplantation); but FIELD shall exclude applications involving the use of cells in the treatment of tumors where the primary use of the cells is the destruction or reduction of tumors and does not involve regeneration of tissue or organ function.
1.4 “KNOW-HOW” means all compositions of matter, techniques and data and other know-how and technical information including inventions (whether or not patentable), improvements and developments, practices, methods, concepts, trade secrets, documents, computer data, computer code, apparatus, clinical and regulatory strategies, test data, analytical and quality control data, formulation, manufacturing, patent data or descriptions, development information, drawings, specifications, designs, plans, proposals and technical data and manuals and all other proprietary information that is owned or controlled by LICENSOR as of the Effective Date that relates to cloning technology or to any of the subject matter described in or claimed by the PATENT RIGHTS and is relevant to the FIELD. By way of illustration, but not in limitation, KNOW-HOW shall include commercial rights to any existing potential research products, including reagents, developed by LICENSOR in the course of its in-house research. An example of this is the proprietary culture medium developed by LICENSOR in the course of the development of LICENSOR’s proprietary ooplasmic transfer technology.
1.5 “LICENSED PROCESS” means any process or method, the research, development, use, practice, sale, offer for sale, import or export of which cannot be performed without (i) infringing, in whole or in part, one or more VALID CLAIMS of the PATENT RIGHTS, or (ii) using or incorporating some portion of the LICENSED TECHNOLOGY.
1.6 “LICENSED PRODUCT” means any product that cannot be developed, manufactured, used, imported, exported, or sold without (i) infringing, in whole or in part, one or more VALID CLAIMS of the PATENT RIGHTS, or (ii) using or incorporating some portion of the LICENSED TECHNOLOGY.
1.7 “LICENSED SERVICES” means any service, the developing, using, performing, selling, offering for sale, importing or exporting of which by LICENSEE would, but for the licenses granted to LICENSEE in Article 2 of this Agreement, infringe a VALID CLAIM of the PATENT RIGHTS in the country in which any such service is so developed, used, performed, sold, offered for sale, imported or exported by LICENSEE.

 

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1.8 “LICENSED TECHNOLOGY” shall mean, collectively, the licensed PATENT RIGHTS and licensed KNOW-HOW.
1.9 “NET SALES” shall mean the amount billed or invoiced by LICENSEE for the sale or provision of LICENSED PRODUCTS or LICENSED PROCESSES or LICENSED SERVICES less:
  a)   discounts, credits, allowances and rebates allowed;
 
  b)   sales, tariff duties, use and other taxes or governmental charges directly imposed with reference to particular sales;
 
  c)   special packaging, transportation and insurance costs incurred and directly related to the sale of LICENSED PRODUCTS;
 
  d)   amounts allowed or credited on returns; and
 
  e)   uncollected accounts.
1.10 “NEURONAL & HEART FIELD OPTION” means an option described in Section 15.18 hereof for LICENSEE to negotiate terms for license to the LICENSED TECHNOLOGY for the field of diseases related to heart or neurodegenerative diseases
1.11 “PATENT RIGHTS” means (a) the patent applications and patents identified on Exhibit A attached hereto and any patents that issue on said applications and (b) any divisions, continuations, extensions, reissues or reexaminations of any of the patents identified in the foregoing clause (a). The Parties agree that Exhibit A may be revised from time to time after the Effective Date to reflect changes thereto that result from the course of patent prosecution.
1.12 “PERSON” shall mean an individual, corporation, partnership, limited liability company, trust, business trust, association, joint stock company, joint venture, pool, syndicate, sole proprietorship, unincorporated organization, governmental authority or any other form of entity not specifically listed herein.
1.13 “TERM” has the meaning set forth in Section 9.1 .
1.14 “TERRITORY” means the entire world.
1.15 “1996 UMASS LICENSE” means the Exclusive License Agreement between LICENSOR and the University of Massachusetts (the “University”), dated April 16, 1996, as amended by the Amendment to Exclusive License Agreement dated September 1, 1999, the Second Amendment to Exclusive License Agreement dated May 31, 2000, and the Third Amendment to Exclusive License Agreement dated September 19, 2002.
1.16 “2003 UMASS LICENSE” means the Exclusive License Agreement between LICENSOR and the University dated April 1, 2003.

 

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1.17 “UMASS LICENSES” means the 1996 UMASS LICENSE and the 2003 UMASS LICENSE.
1.18 “VALID CLAIM” means a claim of any issued and unexpired patent within the PATENT RIGHTS which has not lapsed, become abandoned or been held permanently revoked, invalid, or unenforceable by a decision of a court or administrative or government authority or agency of competent jurisdiction from which no appeal can be or has been taken within the time allowed for such appeal, or a claim of a pending patent application included within the Licensed PATENT RIGHTS, which claim was filed in good faith and has not been abandoned or finally disallowed without the possibility of appeal or refiling of such application.
Additional terms may be defined throughout this Agreement.
ARTICLE 2 — GRANT
2.1 LICENSOR hereby grants to LICENSEE, and LICENSEE hereby accepts, subject to the terms and conditions hereof:
  a)   A royalty bearing, exclusive license in the TERRITORY in the FIELD and under the LICENSED TECHNOLOGY to (a) research, develop, make, have made, use, sell, offer for sale, import and export LICENSED PRODUCTS, (b) research, develop, use, practice, sell, offer for sale, import and export LICENSED PROCESSES and (c) develop, use, perform, sell, offer for sale, import and export LICENSED SERVICES. By way of example, but not in limitation, LICENSEE shall have the right to use LICENSED TECHNOLOGY within the FIELD for the following purposes: to produce mammalian embryonic stem (ES) cells and to produce from those mammalian embryonic cells, differentiated cells for human therapeutic purposes or for commercial research purposes, including drug screening assays, and to produce pluripotent cells including ES cells, differentiated human cells for human diagnostic and therapeutic purposes and/or for commercial research purposes, including drug screening assays.
 
  b)   A royalty bearing, twelve (12) month exclusive license in the TERRITORY in the FIELD to expand in culture, prepare for sale, sell, offer for sale, import and export ACT ANIMAL CELL LINES. The twelve-month term of exclusivity granted to LICENSEE shall begin upon the date of the first sale of the ACT ANIMAL CELL LINES. LICENSOR and LICENSEE agree that after the twelve-month period of exclusivity has passed, LICENSOR AND LICENSEE shall negotiate in good faith to establish reasonable minimum sales goals over reasonable evaluation periods in order to maintain LICENSEE’S exclusive rights hereunder. If LICENSOR fails to meet the minimum sales goals then LICENSEE’s exclusive rights shall revert to nonexclusive rights.

 

4


 

2.2 LICENSEE shall have the right to sublicense the rights granted in Section 2.1 to third parties in connection with contracting with such third parties to (a) provide LICENSED PRODUCT marketing and distribution services to LICENSEE on behalf of LICENSEE, (b) provide LICENSED SERVICES marketing services to LICENSEE on behalf of LICENSEE or (c) manufacture for LICENSEE LICENSED PRODUCTS for sale by LICENSEE or a third party pursuant to the foregoing clause (a).
2.3 LICENSEE shall have the right to grant sublicenses beyond the scope of those described in Section 2.2 (a), (b), and (c) without the express prior written approval of LICENSOR, however, LICENSOR shall be given at least 30 days prior written notice of an intent to sublicense and at least 30 days to comment on the text of the proposed sublicense agreement. In any case, such sublicenses shall meet the following conditions:
  a)   the sublicensee shall not have the right to grant further sublicenses;
 
  b)   the sublicense shall not be assignable without prior written approval by LICENSEE and LICENSOR; and
 
  c)   the sublicense shall include fair consideration consistent with industry norms for upfront fees and royalties.
2.4 Within thirty (30) business days of the Effective Date, LICENSOR shall provide and transfer to LICENSEE, in writing where practicable, all information and data relating to the LICENSED TECHNOLOGY and the ACT ANIMAL CELL LINES as may be reasonably necessary and requested to allow LICENSEE to exploit the licenses granted hereunder. LICENSOR shall work with LICENSEE in good faith to provide the necessary training for up to a total of 60 days, at LICENSOR’s facilities, necessary to allow LICENSEE to utilize the LICENSED TECHNOLOGY and expand the ACT ANIMAL CELL LINES. LICENSEE shall pay to LICENSOR all reasonable and customary expenses other than normal operating expenses incurred by LICENSOR in providing such training and technology transfer, including but not limited to fees incurred to request documents from patent counsel or the United States Patent and Trademark Office.
2.5 LICENSEE acknowledges that a portion of the PATENT RIGHTS licensed to LICENSEE hereunder is owned by the University and is licensed to LICENSOR under the UMASS LICENSES. In the event the UMASS LICENSES expire or are terminated for any reason pursuant to the provisions of the UMASS LICENSES or otherwise, the terms of the letter agreement attached hereto as Exhibit B between LICENSOR, LICENSEE and the University shall apply to this Agreement.

 

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2.6 Notwithstanding anything stated herein, nothing in this Agreement shall be construed as preventing LICENSOR from practicing the LICENSED TECHNOLOGY within the FIELD for non-commercial in-house research purposes. In the event that LICENSOR requests that LICENSEE deliver to LICENSOR the LICENSED TECHNOLOGY or LICENSED PRODUCTS in the FIELD for research purposes, LICENSEE shall make the LICENSED TECHNOLOGY or LICENSED PRODUCTS available to LICENSOR on commercially reasonable terms. In the event LICENSOR requires the use of collaborators in its research, LICENSEE shall also make such LICENSED TECHNOLOGY OR LICENSED PRODUCTS available to such collaborator if LICENSEE, in its sole but reasonable discretion is satisfied that providing such items to a collaborator will not endanger its exclusive commercial control of such items or result in their use by a competitor.
ARTICLE 3 — LICENSEE OBLIGATIONS
RELATING TO COMMERCIALIZATION
3.1 LICENSEE shall use its commercially reasonable and diligent efforts to bring one or more LICENSED PRODUCTS, LICENSED PROCESSES or LICENSED SERVICES to market through an active and diligent program for exploitation of the PATENT RIGHTS and to continue active, diligent marketing efforts for one or more LICENSED PRODUCTS, LICENSED PROCESSES or LICENSED SERVICES throughout the TERM of this Agreement.
3.2 LICENSEE shall maintain minimum R&D requirements to maintain exclusivity under this Agreement . Commencing 30 months following the Effective Date hereof and until the launch of the first human cell-based therapeutic product, LICENSEE shall be required to invest a minimum of $400,000 per year in research and development of the FIELD covered by this Agreement or other agreements with LICENSOR affecting the FIELD in order to maintain the exclusive license rights granted hereunder. In the event LICENSEE fails to perform this minimum expenditure in R&D in the FIELD during the course of a calendar year during the above-mentioned period, the license under this Agreement shall become nonexclusive and such minimum expenditure for research and development shall be reduced to $200,000 per year.
3.3 LICENSEE shall maintain complete and accurate records of LICENSED PRODUCTS, LICENSED PROCESSES, LICENSED SERVICES and ACT ANIMAL CELL LINES that are made, used, sold or performed by LICENSEE under this Agreement. Not later than April 1 st of each year following the Effective Date, LICENSEE shall furnish LICENSOR with a summary report on the progress of its efforts during the prior year to develop and commercialize LICENSED PRODUCTS, LICENSED PROCESSES, LICENSED SERVICES or ACT ANIMAL CELL LINES, including without limitation research and development efforts, efforts to obtain regulatory approval, marketing efforts (including LICENSED PRODUCTS, LICENSED PROCESSES, LICENSED SERVICES and ACT ANIMAL CELL LINES made, used, sold or performed) and sales figures, provided that such reports shall be deemed Confidential Information (as defined in Section 10.1 herein) subject to the provisions of Article 10 of this Agreement.

 

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3.4 In the event that LICENSOR determines that LICENSEE has not fulfilled its obligations under this Article 3 , LICENSOR shall furnish LICENSEE with written notice of such determination. Within thirty (30) days after receipt of such notice, LICENSEE shall (i) fulfill the relevant obligation, (ii) negotiate with LICENSOR a mutually acceptable schedule of revised obligations, or (3) if LICENSEE disputes the alleged failure to fulfill its obligations, it shall promptly seek appropriate judicial determination of the matter and diligently pursue such action to a final determination with all appropriate speed; failing which, LICENSOR shall have the right, immediately upon written notice to LICENSEE, to terminate this Agreement as provided in Section 9.2 hereof.
ARTICLE 4 — CONSIDERATION
4.1 Initial Payment . In partial consideration of the license granted to LICENSEE from LICENSOR in Article 2 of this Agreement, LICENSEE agrees to pay as a “License Fee” to LICENSOR $150,000 in a convertible promissory note in the form attached hereto as Exhibit C.
4.2 Royalties .
  a)   In partial consideration of the license in the FIELD granted by LICENSOR to LICENSEE in Article 2 of this Agreement, LICENSEE agrees to pay to LICENSOR an earned royalty equal to the following percentages of the NET SALES in the FIELD made, used, sold, imported, exported or performed by LICENSEE in the TERRITORY.
(i) 6% on therapeutics,
(ii) 3% on diagnostics, and
(iii) 10% on commercial research use of LICENSED TECHNOLOGY in all FIELDS except (iv) below and
(iv) 12% on ACT ANIMAL CELL LINES
  b)   No multiple royalties shall be payable because any LICENSED PRODUCT, LICENSED PROCESS or LICENSED SERVICE in the FIELD, its manufacture, use, lease, sale or performance are or shall be covered by more than one patent or patent application within the PATENT RIGHTS.
 
  c)   The obligation of LICENSEE to pay royalties or Sublicense Income (as defined in Section 4.5 herein) hereunder shall terminate for each country in the TERRITORY concurrently with the expiration or termination of the last applicable VALID CLAIM within the PATENT RIGHTS in such country in which the LICENSED PRODUCT, LICENSED PROCESS or LICENSED SERVICE is, (as applicable), used, practiced, performed, sold, offered for sale, imported, exported or manufactured.

 

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4.3 Minimum Royalties . Within 2 business days from the Effective Date hereof, LICENSEE shall pay to LICENSOR a minimum royalty fee of $100,000 in cash or by wire transfer. In addition, commencing 12 months following the Effective Date, LICENSEE shall pay to LICENSOR additional minimum royalty fees equal to the difference between total Royalties actually paid in the preceding 12 months and the following minimum amounts:
(i) At 12 months, $10,000
(ii) At 24 months, $20,000
(iii) At 36 months, $30,000
(iv) Annually thereafter, $40,000.
4.4 Stacking Royalties . With the exception of minimum royalties due to LICENSOR, if LICENSEE, its Affiliates or sublicensees are required to pay royalties relating to any additional intellectual property from LICENSOR in order to exercise its rights hereunder to make, have made, use or sell any Product, then LICENSEE shall have the right to credit a pro-rated portion of such royalty payments against the royalties owing to LICENSOR under Section 4.2 of this Agreement with respect to sales of such Product such that in no event shall the total of royalty payments that are due to LICENSOR in such royalty period exceed the royalty payments payable under Subsection 4.2(a) above. Prorations shall be made in the same manner as specified for combination products under Section 4.9 below.
4.5 Sublicense Income . LICENSEE shall pay to LICENSOR a total of Thirty Three percent (33%) of all Sublicense Income. “Sublicense Income” means consideration that LICENSEE receives for the sublicense of rights that are granted LICENSEE under Article 2 , including without limitation license fees, milestone payments, equity payments, up front fees, success fees, and license maintenance fees.
4.6 Stacking Sublicense Income. The fees payable on Sublicense Income under Section 4.5 above shall be in addition to any royalties specified elsewhere in this Article 4 , but if LICENSEE is obligated to pay or has paid to LICENSOR similar fees on Sublicense Income under another license agreement with respect to the FIELD, then LICENSEE shall have the right to pro-rate such fees against the fees owing to LICENSOR under this Agreement such that in no event shall the total of fees due from LICENSEE, as a result of Sublicense Income, to LICENSOR exceed the payments payable under Section 4.5 . Pro-rating of payments shall be made in the ratio of the minimum royalties payable under this Agreement to the minimum royalties payable under any other agreement covered hereby under which fees on Sublicense Income are owed.
4.7 Milestone Payments. Upon the launch of a commercial therapeutic product based on the LICENSED TECHNOLOGY, LICENSEE shall pay additional Milestone Payments totaling $1,750,000 on the following schedule:
$250,000 within 30 days following the launch of the first commercial Product;
$500,000 upon reaching $5,000,000 in sales from one or both Product Fields;
$1,000,000 upon reaching $10,000,000 in sales from one or both Product Fields.

 

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4.8 Stacking Milestone Payments. The milestone payments shall be in addition to any royalties specified elsewhere in this Article 4 , but shall not apply to diagnostic, commercial research, or any other non-therapeutic uses. If LICENSEE is obligated to pay or has paid to LICENSOR similar Milestone Payments under another license agreement with respect to the FIELD, then LICENSEE shall have the right to pro-rate such Milestone Payments against the Milestone Payments owing to LICENSOR under this Agreement such that in no event shall the total of all Milestone Payments due from LICENSEE to LICENSOR exceed the amounts stated in Section 4.7 . Pro-rating of payments shall be made in the ratio of the minimum royalties payable under this Agreement to the minimum royalties payable under any other agreement covered hereby under which Milestone Payments are owed.
4.9 Combination Product . In the event a Product is sold in a combination product with other devices or biologically active components, NET SALES, for purposes of royalty payments on the combination product, shall be calculated by multiplying the NET SALES of that combination by the fraction A/B, where A is the gross selling price of the Product sold separately and B is the gross selling price of the combination product. In the event that no such separate sales are made by LICENSEE, its Affiliates or permitted sublicensees, NET SALES for royalty determination shall be calculated by multiplying NET SALES of the combination by the fraction C/(C+D), where C is the fully allocated cost of the Product and D is the fully allocated cost of such other biologically active components.
4.10 Payments in U.S. Currency . All payments due under this Agreement shall be paid in cash to LICENSOR and all payments shall be made in United States currency. Conversion of foreign currency to U.S. dollars shall be made at the conversion rate reported in The Wall Street Journal on the last working day of the calendar quarter to which the payment relates.
4.11 Taxes . Subject to the limits of Section 1.9 hereof, all payments due hereunder shall be paid in full without deduction of taxes or other fees which may be imposed by any government and which shall be paid by LICENSEE; provided, however, that any withholding tax required to be withheld by LICENSEE on royalty payments under the laws of any country in the TERRITORY on behalf of LICENSOR will be timely paid by LICENSEE to the appropriate governmental authority, and LICENSEE will furnish LICENSOR with proof of payment of such tax. Any such tax actually withheld may be deducted from royalty payments due to LICENSOR under this Agreement. If at any time legal restrictions prevent the prompt remittance of part or all of any payments owed by LICENSEE to LICENSOR hereunder with respect to any country in the TERRITORY, payment shall be made through any lawful means or methods that may be available, and as LICENSEE shall reasonably determine is appropriate.
4.12 Overdue Payments . Any payments to be made by LICENSEE hereunder that are not paid on or before the date such payments are due under this Agreement shall bear interest, to the extent permitted by law, at two percentage points above the Prime Rate of interest as reported in The Wall Street Journal on the date payment is due, with interest calculated based on the number of days that payment is delinquent.

 

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ARTICLE 5 — REPORTS AND RECORDS
5.1 LICENSEE shall keep full, true and accurate books of account containing all particulars that may be necessary for the purpose of showing the amounts payable to LICENSOR hereunder and to enable the reports provided under Section 5.2 to be verified. Said books of account shall be kept at LICENSEE’s principal place of business. Said books and the supporting data shall be open upon reasonable advance notice (but not less than five (5) business days notice and no more frequently than once per calendar year) for three (3) years following the end of the calendar year to which they pertain, to the inspection of LICENSOR or its agents for the purpose of verifying LICENSEE’s royalty and Sublicense Income statement or compliance in other respects with this Agreement. If any such audit determines an error in any royalty or Sublicense Income payment, LICENSEE shall pay to LICENSOR, within thirty (30) days of the discovery of the error, (a) all deficiencies in royalty or Sublicense Income payments, (b) interest on such deficiencies from the date such royalty or Sublicense Income payment was due until the date paid at the rate set forth in Section 4.12 above, and (c) if such error is in excess of five percent (5%) of any royalty or Sublicense Income payment, the cost of the audit. In all other cases, the costs of the audit shall be paid for by LICENSOR. All information disclosed pursuant to an audit shall be treated as Confidential Information (as defined in Section 10.1 herein) and shall not be disclosed to any third party or used for any purpose other than to determine the correctness of LICENSEE’s royalty and Sublicense Income statement or compliance in other respects with this Agreement.
5.2 After the first commercial sale of a LICENSED PRODUCT, LICENSED PROCESS, LICENSED SERVICES, or ACT ANIMAL CELL LINES, LICENSEE, within forty-five (45) days after March 31, June 30, September 30 and December 31 of each year, shall deliver to LICENSOR a true and accurate report, giving such particulars of the business conducted by LICENSEE and its permitted sublicensees during the preceding three-month period under this Agreement as shall be pertinent to a royalty and Sublicense Income accounting hereunder. Without limiting the generality of the foregoing, these reports shall include at least the following:
  a)   the number of LICENSED PRODUCTS and ACT ANIMAL CELL LINES manufactured and sold by LICENSEE and all sublicensees;
 
  b)   total billings and the amounts actually received for LICENSED PRODUCTS and ACT ANIMAL CELL LINES sold by LICENSEE and all sublicensees;
 
  c)   an accounting for all LICENSED PROCESSES or LICENSED SERVICES used in the provision of services to others or sold by LICENSEE;
 
  d)   the deductions applicable as provided in Section 1.9 ; and
 
  e)   the names and addresses of all parties making LICENSED PRODUCTS on behalf of LICENSEE.

 

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The reports shall provide the above-identified information by product, process, or service type.
5.3 With each such report submitted, LICENSEE shall pay to LICENSOR the royalties and Sublicense Income due and payable for such three-month period. If no royalties or Sublicense Income shall be due, LICENSEE shall so report.
ARTICLE 6 — PATENT PROSECUTION
6.1 LICENSOR shall be solely responsible for the continued prosecution of pending patent applications included in the PATENT RIGHTS and the issuance of such applications after allowance. The prosecution, filing and maintenance of all patents and applications shall be the primary responsibility of LICENSOR. LICENSEE agrees to cooperate fully with LICENSOR, as requested by LICENSOR and at LICENSOR’s expense, in the preparation, filing, prosecution, and maintenance of the patent applications and patents included in the PATENT RIGHTS. With respect to Australia, Canada, Europe, Mexico, Japan and Israel, LICENSEE shall pay to LICENSOR on or before the due date one half (1/2) of any future annuity and maintenance fees with respect to UMA 99-19, provided LICENSOR notifies LICENSEE of the amount of such payments due at least 30 days prior to their due date.
6.2 Licensors will not allow any patent or patent application within the PATENT RIGHTS to become expired or abandoned without giving (a) prior written notice to LICENSOR of such expiration or abandonment, and (b) LICENSOR the right to assume responsibility for such patent or patent application subject to the rights of the University under the UMASS LICENSES and the rights of pre-existing licensees under their respective licenses. LICENSOR will then assign such patent or patent application to LICENSEE and LICENSEE will thereafter assume control thereof and all expenses related thereto.
ARTICLE 7 — PROSECUTION OF INFRINGERS
AND DEFENSE OF PATENT RIGHTS
The Parties agree to notify each other in writing of any actual or threatened infringement by a third party of the PATENT RIGHTS or of any claim of invalidity, unenforceability, or non-infringement of the PATENT RIGHTS. LICENSOR shall have the sole responsibility to prosecute or defend such claims, as applicable. LICENSEE shall, if requested, provide reasonable assistance to LICENSOR in connection with the prosecution or defense of such claims.

 

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ARTICLE 8 — INDEMNIFICATION
8.1 Indemnification of the LICENSOR and the University . LICENSEE shall be responsible for and shall indemnify, defend, and hold harmless LICENSOR and the University, and their agents, attorneys, representatives, third party beneficiaries and their respective heirs, executors, successors and assigns (collectively, the “LICENSOR Indemnitees”) from and against all liabilities of any kind whatsoever, including legal expenses and reasonable attorneys’ fees, incurred or imposed upon any of the LICENSOR Indemnitees in connection with or as a consequence of any claims (including third party claims), suits, actions, demands or judgments arising out of the death of or injury to any person or persons or out of any damage to property resulting from the development, production, manufacture, sale, use, performance, rendering, consumption or advertisement of the LICENSED PRODUCT(s) and/or LICENSED PROCESS(es), LICENSED SERVICE(s), and/or ACT ANIMAL CELL LINES or arising from any obligation, act or omission performed or failed to be performed hereunder, or from a breach of any representation or warranty of LICENSEE hereunder unless and to the extent that such liability arises solely from any action of LICENSOR or any of its Affiliates. If the exercise of LICENSEE’s rights under this Agreement in any country in the TERRITORY is the subject of a bona fide claim by a third party, filed in a court of competent jurisdiction after the date hereof, that the exercise of such rights infringes or conflicts with any intellectual property rights of such third party (a “Third Party Infringement Claim”), then LICENSEE shall not have any of the rights granted herein in such country and shall have no obligation to pay LICENSOR any further payments under Article 4 of this Agreement with respect to any country of the TERRITORY until such claim is resolved by proper adjudication or settlement permitting LICENSEE to exercise LICENSEE’s rights under this Agreement in the applicable country of the TERRITORY. Notwithstanding anything herein to the contrary, LICENSOR covenants that it will not (a) assert or bring any suit, action, claim or other proceeding against LICENSEE based on, in whole or in part, LICENSEE’s exercise of LICENSEE’s rights, in accordance with the terms and conditions of this Agreement, with respect to the LICENSED TECHNOLOGY and/or (b) join in any third party suit, action, claim or other proceeding against LICENSEE based on, in whole or in part, any intellectual property rights (including without limitation, patent rights and/or know how) owned by the applicable third party, so long as LICENSEE is not in violation of this Agreement.
8.2 Indemnification of the LICENSEE . LICENSOR shall be responsible for and shall indemnify, defend, and hold harmless LICENSEE and the officers, directors, shareholders, employees, agents, attorneys, representatives, and Affiliates, and their respective heirs, executors, successors and assigns. (the “LICENSEE Indemnitees”) from and against all liabilities of any kind whatsoever, including legal expenses and reasonable attorneys’ fees, incurred or imposed upon any of the LICENSEE Indemnitees in connection with or as a consequence of any claims (including third party claims), suits, actions, demands or judgments arising out of, directly or indirectly, or in any way relating to: (a) any breach by LICENSOR of any representation, warranty, covenant or obligation set forth in this Agreement; or (b) arising from LICENSOR’s ownership, management, control, use or disposition of the LICENSED TECHNOLOGY or ACT ANIMAL CELL LINES unless and to the extent that such liability arises solely from any action of LICENSEE or any of its Affiliates after the Effective Date.

 

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8.3 Demands for Third Party Claims . Each indemnified Party hereunder (an “Indemnified Party”) agrees that promptly upon its discovery of facts giving rise to a claim for indemnity under this Agreement, including the receipt of any demand, assertion, claim, action or proceeding, judicial or otherwise, by any third party (being referred to herein as a “Claim”), with respect to any matter as to which it claims to be entitled to indemnity under the provisions of this Agreement, it will give prompt notice thereof in writing to the Indemnifying Party (the “Indemnifying Party”), together with a statement of such information respecting any of the foregoing as it shall have. Such notice shall include a formal demand for indemnification under this Agreement.
8.4 Right to Contest and Defend . The Indemnifying Party shall contest and defend, at its sole cost and expense, by all appropriate legal proceedings any Claim with respect to which it is called upon to indemnify the Indemnified Party under the provisions of this Agreement; provided, that notice of the intention to so contest shall be delivered by the Indemnifying Party to the Indemnified Party as soon as reasonably possible after (but no later than twenty 20 days from) the date of receipt by the Indemnifying Party of notice by the Indemnified Party of the assertion of the Claim. Any such contest may be conducted in the name and on behalf of the Indemnifying Party or the Indemnified Party as may be appropriate. Such contest shall be conducted by reputable counsel employed by the Indemnifying Party, but the Indemnified Party shall have the right but not the obligation to participate in such proceedings and to be represented by counsel of its own choosing at its sole cost and expense. The Indemnifying Party shall have full authority to determine all action to be taken with respect thereto; provided, however, that the Indemnifying Party will not have the authority to subject the Indemnified Party to any obligation whatsoever (whether financial or the imposition of equitable or injunctive relief), other than the performance of purely ministerial tasks or obligations not involving material expense (for which the Indemnified Party shall be reimbursed). If the Indemnifying Party does not elect to contest any such Claim, the Indemnifying Party shall be bound by the result obtained with respect thereto by the Indemnified Party.
8.5 Cooperation . If requested by the Indemnifying Party, the Indemnified Party agrees to cooperate with the Indemnifying Party and its counsel in contesting any Claim that the Indemnifying Party elects to contest or, if appropriate, in making any counterclaim against the PERSON asserting the Claim, or any cross-complaint against any PERSON, and the Indemnifying Party will reimburse the Indemnified Party for any expenses incurred by it in so cooperating.
8.6 Right to Participate . The Indemnified Party agrees to afford the Indemnifying Party and its counsel the opportunity to be present at, and to participate in, conferences with any PERSON, including governmental authorities, asserting any Claim against the Indemnified Party or conferences with representatives of or counsel for such PERSON.
8.7 Payment of Damages . The Indemnifying Party shall pay to the Indemnified Party in immediately available funds any amounts to which the Indemnified Party may become entitled by reason of the provisions of this Agreement, such payment to be made within five (5) days after any such amounts are finally determined either by mutual agreement of the Parties hereto or pursuant to the final non-appealable judgment of a court of competent jurisdiction.

 

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8.8 Independent Indemnities . The Parties acknowledge and agree that each of the indemnities under Sections 8.1 and 8.2 may be relied upon independently.
8.9 Insurance. LICENSEE and LICENSOR mutually agree to maintain insurance or self-insurance that is reasonably adequate to fulfill any potential obligation to the Indemnified Parties. LICENSEE and LICENSOR shall continue to maintain such insurance or self-insurance during the term of this Agreement and after the expiration or termination of this Agreement for a period of five (5) years. Each Party shall provide to the other Party, upon request, proof of any such insurance policy maintained by such Party.
ARTICLE 9 — TERMINATION
9.1 The term of this Agreement (“TERM”) shall commence on the Effective Date and continue until the expiration of the last VALID CLAIM within the PATENT RIGHTS to expire , unless sooner terminated as provided in this Article 9 ; provided that LICENSEE’s obligation to pay royalties or Sublicense Income on NET SALES in any country will terminate pursuant to Subsection 4.2(c) (subject to LICENSEE’s obligations under Section 9.4 herein).
9.2 If either Party commits a material breach of a material term of this Agreement (including any failure to make any payment due under this Agreement), the non-breaching Party shall have the right to terminate this Agreement effective on thirty (30) days prior written notice to the Party in breach, unless such breach is cured prior to the expiration of such thirty (30) day period.
9.3 LICENSEE shall have the right to terminate this Agreement at any time on thirty (30) days prior notice to LICENSOR, and upon payment of all amounts due LICENSOR through the effective date of the termination.
9.4. Notwithstanding anything herein to the contrary, in the event that this Agreement is terminated by LICENSOR pursuant to Section 9.2 or by LICENSEE pursuant to Sections 9.2 or 9.3 , LICENSEE shall retain a license to rights granted in Article 2 to the extent reasonably necessary to sell any LICENSED PRODUCTS existing or under production and to perform LICENSED PROCESSES or LICENSED SERVICES related to such LICENSED PRODUCTS or that are in process, subject to the terms of this Agreement (including without limitation the obligation to pay royalties under Article 4 ), provided that LICENSEE shall complete and sell all such work-in-progress and inventory within six (6) months after the effective date of termination.
9.5 Upon the expiration of the TERM of this Agreement LICENSEE shall have a fully paid-up, non-exclusive, irrevocable, royalty free license under the rights granted in Article 2 .

 

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9.6 Nothing herein shall be construed to release either Party from any obligation that accrued prior to expiration or any termination of this Agreement. The following provisions shall survive any termination or any expiration of the TERM of this Agreement: this Section 9.6 and Articles/Sections 1, 4, 5, 8, 9.4, 10, 11, 12, 13, 15.1, 15.2, 15.5, 15.6, 15.7, 15.8, 15.10, 15.15 and 15.16 , and any other provision which by its nature is intended to survive any such termination.
ARTICLE 10 — CONFIDENTIALITY AND NON-DISCLOSURE
10.1 Confidential Information; Non-Disclosure . “Confidential Information” shall mean any technical, business, financial, customer or other information disclosed by one Party (the “Disclosing Party”) to the other Party (the “Receiving Party”) pursuant to this Agreement which is marked “Confidential” or “Proprietary,” or which, under all of the given circumstances, ought reasonably to be treated as confidential information of the Disclosing Party. Such information may be disclosed in oral, visual or written form (including magnetic, optical or other media). Except as expressly provided in Section 10.2 below, each Party’s Confidential Information specifically includes without limitation the respective Party’s business plans and business practices, the terms of this Agreement, scientific knowledge, research and development or know-how, processes, inventions, techniques, formulae, products and product plans, business operations, customer requirements, designs, sketches, photographs, drawings, specifications, reports, studies, findings, data, plans or other records, biological materials, software, margins, payment terms and sales forecasts, volumes and activities, designs, computer code, technical information, costs, pricing, financing, business opportunities, personnel, and information of LICENSOR or LICENSEE relating to the LICENSED PROCESSES, LICENSED PRODUCTS or LICENSED SERVICES whether or not such information is marked or identified provided that the Disclosing Party provides notice in writing reasonably identifying such Confidential Information within 30 days of disclosure. Except to the extent expressly authorized by this Agreement or by other prior written consent by the Disclosing Party, the Receiving Party, during the term of this Agreement, and thereafter, shall: (i) treat as confidential all Confidential Information of the other Party; (ii) use Confidential Information only for exercising the rights and fulfilling the obligations set forth in this Agreement, (iii) implement reasonable procedures to prohibit the disclosure, unauthorized duplication, misuse or removal of the Disclosing Party’s Confidential Information; (iv) not disclose Confidential Information to any third party, and (v) only disclose the Confidential Information to (a) those of its employees who have a need to know Confidential Information in order to exercise the rights and fulfill the obligations set forth in this Agreement and (b) legal and professional advisors and existing and potential investors and their legal and professional advisors, each of which is bound by a written agreement (or in the case of attorneys or other professional advisors, formal ethical duties) requiring such advisors and investors to treat, hold and maintain such Confidential Information in accordance with the terms and conditions of this Agreement, or (c) recipients of offering documents in connection with any offering of securities where such disclosure is, in the opinion of counsel for the

 

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Disclosing Party, reasonably required to comply with the investment disclosure laws of any applicable jurisdiction. Without limiting the foregoing, the Receiving Party shall protect the Disclosing Party’s Confidential Information using at least the same procedures and degree of care that it uses to prevent the disclosure of its own confidential information of like importance, but in no event less than reasonable care.
10.2 Exceptions . The Receiving Party shall have no obligation or liability to the Disclosing Party with regard to any Confidential Information of the Disclosing Party: (i) that was publicly known and available at the time it was disclosed or becomes publicly known and available through no fault, action, or inaction of the Receiving Party; (ii) was known to the Receiving Party, without restriction, at the time of disclosure as shown by the files of the Receiving Party in existence at the time of disclosure; (iii) is disclosed with the prior written approval of the Disclosing Party; (iv) was independently developed by the Receiving Party without any use of the disclosing party’s Confidential Information, provided, that the Receiving Party can demonstrate such independent development by documented evidence prepared contemporaneously with such independent development; (v) is disclosed pursuant to the order or requirement of a court, administrative agency, or other governmental body, provided that the Receiving Party shall provide prompt notice thereof and reasonable assistance to the Disclosing Party to enable the Disclosing Party to seek a protective order or otherwise prevent such disclosure, and provided further that such disclosure is limited to the extent necessary to comply with such order and the information shall otherwise be treated as Confidential Information; or (vi) that is provided to the Receiving Party by an independent third party without violating any confidentiality obligation to the Disclosing Party.
10.3 Injunctive Relief . LICENSOR and LICENSEE acknowledge and agree that any breach of the confidentiality obligations imposed by this Article 10 will constitute immediate and irreparable harm to the Disclosing Party and/or its successors and assigns, which cannot adequately and fully be compensated by money damages and will warrant, in addition to all other rights and remedies afforded by law, injunctive relief, specific performance, and/or other equitable relief. The Disclosing Party’s rights and remedies hereunder are cumulative and not exclusive. The Disclosing Party shall also be entitled to receive from the Receiving Party the costs of enforcing this Article 10 , including reasonable attorneys’ fees and expenses of litigation.
10.4 Termination . Upon termination or expiration of this Agreement, or upon the request of the Disclosing Party at any time, the Receiving Party shall promptly return to the Disclosing Party, at its request, all copies of Confidential Information received from the Disclosing Party, and shall return or destroy, and document the destruction of, all summaries, abstracts, extracts, or other documents which contain any Confidential Information of the Disclosing Party in any form. Notwithstanding the foregoing to the contrary, LICENSEE shall have no obligation (even upon a request by LICENSOR) to return or destroy any KNOW-HOW (including tangible embodiments of KNOW-HOW) during the TERM of this Agreement.
10.5 Survival . The obligations of LICENSOR and LICENSEE under this Article 10 shall survive any expiration or termination of this Agreement.

 

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ARTICLE 11 — PAYMENTS, NOTICES, AND OTHER COMMUNICATIONS
Any payment, notice or other communication pursuant to this Agreement shall be in writing and sent by certified first class mail, postage prepaid, return receipt requested, or by nationally recognized overnight carrier addressed to the Parties at the following addresses or such other addresses as such Party furnishes to the other Party in accordance with this paragraph. Such notices, payments, or other communications shall be effective upon receipt.
In the case of LICENSOR:
Advanced Cell Technology, Inc.
One Innovation Drive
Worcester, MA 01605
Attention: Michael D. West, Ph.D., President
With a copy to:
Pierce Atwood
One Monument Square
Portland, ME 04101
Attention: William L. Worden, Esq.
In the case of LICENSEE:
PacGen Cellco, LLC.
157 Surfview Drive
Pacific Palisades, CA 90272
Attention: Kenneth Aldrich
With a copy to:
Gray Cary Ware & Freidenrich
4365 Executive Drive, Suite 1100
San Diego, CA 92121-2133
Attention: Lisa Haile

 

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ARTICLE 12 — RESPRESENTATIONS AND WARRANTIES OF LICENSOR
As an inducement to LICENSEE to enter into and perform this Agreement, LICENSOR represents and warrants to LICENSEE as follows:
12.1 Title to LICENSED TECHNOLOGY; Encumbrances . LICENSOR has good and valid title or valid licenses (with the right of sublicense) to the LICENSED TECHNOLOGY.
12.2 No Violations . The execution, delivery and performance of this Agreement by LICENSOR and the consummation by LICENSOR of the transactions contemplated hereby does not,: (a) violate any statute, ordinance, rule or regulation applicable to LICENSOR or by which any of the LICENSED TECHNOLOGY may be bound; (b) violate any order, judgment or decree of any court or of any Governmental Authority or regulatory body, agency or authority applicable to LICENSOR or by which any of the LICENSED TECHNOLOGY may be bound; (c) require any filing by LICENSOR with, or require LICENSOR to obtain any permit, consent or approval of, or require LICENSOR to give any notice to, any Governmental Authority or regulatory body, agency or authority; or (d) result in a violation or breach by LICENSOR of, conflict with, constitute a default by LICENSOR (or give rise to any right of termination, cancellation, payment or acceleration) under or result in the creation of any Encumbrance upon any of the LICENSED TECHNOLOGY.
12.3 Litigation . Except as set forth in Exhibits D and E , there is no action, suit, proceeding at law or in equity, arbitration or administrative or other proceeding by or before (or any investigation by) any governmental or other instrumentality or agency, pending, or threatened, against or affecting the LICENSED TECHNOLOGY, and LICENSOR does not know of any valid basis for any such action, proceeding or investigation. To the knowledge of LICENSOR, there are no such suits, actions, claims, proceedings or investigations pending or threatened, seeking to prevent or challenge the transactions contemplated by this Agreement.
12.4 Disclosure . Neither these representations and warranties made by LICENSOR pursuant to this Agreement nor any of the exhibits, schedules or certificates attached hereto or delivered in accordance with the terms hereof knowingly contains any misstatement of fact or omits any statement of fact necessary in order to make the statements contained herein and therein not misleading in light of the circumstances under which they were made.
12.5 Copies of Documents . LICENSOR has caused to be made available for inspection and copying by LICENSEE and its advisers, true, complete and correct copies of all documents in LICENSOR’s possession referred to in any schedule attached hereto.
12.6 Broker’s or Finder’s Fees . No agent, broker, person or firm acting on behalf of LICENSOR is, or will be, entitled to any fee, commission or broker’s or finder’s fees for which the LICENSEE may be liable in connection with this Agreement or any of the transactions contemplated hereby.

 

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12.7 LICENSED TECHNOLOGY .
  (a)   Except as set forth on Exhibit D and E , LICENSOR, is not aware of any interference, infringement, misappropriation, or other conflict with any intellectual property rights of third parties, and LICENSOR has never received any charge, complaint, claim, demand, or notice alleging any such interference, infringement, misappropriation, or violation (including any claim that LICENSOR must license or refrain from using any intellectual property rights of any third party). To the knowledge of LICENSOR, no third party has interfered with, infringed upon, misappropriated, or otherwise come into conflict with any of the LICENSED TECHNOLOGY.
 
  (b)   Exhibit A identifies each patent or registration which has been issued or licensed to LICENSOR with respect to any of the LICENSED TECHNOLOGY and identifies each pending patent application or application for registration which LICENSOR has made with respect to any of the LICENSED TECHNOLOGY. LICENSOR has made available to LICENSEE correct and complete copies of all such patents, registrations and applications (as amended to-date) in LICENSOR’s possession and has made available to LICENSEE correct and complete copies of all other written documentation in LICENSOR’s possession evidencing ownership and prosecution (if applicable) of each such item.
 
  (c)   Exhibit A identifies each item of LICENSED TECHNOLOGY that is assigned to the University and that LICENSOR uses pursuant to license, sublicense, agreement, or permission. LICENSOR has made available to LICENSEE correct and complete copies of all such licenses, sublicenses, agreements, patent prosecution files and permissions (as amended to-date) in LICENSOR’s possession. With respect to each item of LICENSED TECHNOLOGY required to be identified in Exhibit A and to the knowledge of LICENSOR: (i) the license, sublicense, agreement, or permission covering the item is legal, valid, binding, enforceable, and in full force and effect; (ii) the license, sublicense, agreement, or permission will continue to be legal, valid, binding, enforceable, and in full force and effect on identical terms following the consummation of the transactions contemplated hereby; (iii) no Party to the license, sublicense, agreement, or permission is in breach or default, and no event has occurred which with notice or lapse of time would constitute a breach or default or permit termination, modification, or acceleration thereunder; (iv) no party to the license, sublicense, agreement, or permission has repudiated any provision thereof; (v) the underlying item of LICENSED TECHNOLOGY is not subject to any outstanding lien or encumbrance, injunction, judgment, order, decree, ruling, or charge other than that disclosed in Exhibits D and E; (vi) no action, suit, proceeding, hearing, investigation, charge, complaint, claim, or demand is pending or is threatened which challenges the legality, validity, or enforceability of the underlying item of LICENSED TECHNOLOGY other than that disclosed in Exhibits D and E; and (vii) LICENSOR has not granted any sublicense or similar right to the LICENSED TECHNOLOGY within the FIELD.

 

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12.8 Survival of Representations and Warranties .
  (a)   Except as otherwise provided herein, notwithstanding any investigation at any time made by or on behalf of any Party hereto, the representations and warranties set forth herein and in any certificate delivered in connection herewith with respect to any of those representations and warranties will survive the Effective Date until the longer to occur of: (i) two (2) years or (ii) the expiration of the applicable statutes of limitation, including all periods of extension and tolling whereupon they will terminate and expire.
 
  (b)   After a representation and warranty has expired, as provided in Subsection 12.8(a) , no claim for claims or costs may be made or prosecuted by any Person who would have been entitled to claims or costs on the basis of that representation and warranty prior to its termination and expiration, provided that no claim presented in writing for claims or costs to the Person or Persons from which or whom those damages are sought on the basis of that representation and warranty prior to its termination and expiration will be affected in any way by that termination and expiration.
12.9 EXCEPT AS OTHERWISE EXPRESSLY SET FORTH IN THIS AGREEMENT, LICENSOR, ITS DIRECTORS, OFFICERS, EMPLOYEES, AND AFFILIATES MAKE NO REPRESENTATIONS AND EXTEND NO WARRANTIES OF ANY KIND, EITHER EXPRESS OR IMPLIED, INCLUDING BUT NOT LIMITED TO WARRANTIES OF MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE, VALIDITY OF PATENT RIGHTS, ISSUED OR PENDING, AND THE ABSENCE OF LATENT OR OTHER DEFECTS, WHETHER OR NOT DISCOVERABLE. NOTHING IN THIS AGREEMENT SHALL BE CONSTRUED AS A REPRESENTATION MADE OR WARRANTY GIVEN BY LICENSOR THAT THE PRACTICE BY LICENSEE OF THE LICENSE GRANTED HEREUNDER SHALL NOT INFRINGE THE PATENT RIGHTS OF ANY THIRD PARTY.
ARTICLE 13—REPRESENTATIONS AND WARRANTIES OF LICENSEE.
LICENSEE represents and warrants to LICENSOR as follows:
13.1 Existence and Good Standing: Power and Authority . LICENSEE is a limited liability company duly organized, validly existing and in good standing under the laws of the state of California. LICENSEE has full corporate power and authority to make, execute, deliver and perform this Agreement, to perform its obligations hereunder and to consummate the

 

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transactions contemplated hereby. The execution, delivery and performance of this Agreement by LICENSEE and the consummation by it of the transactions contemplated hereby, have been duly authorized and approved by all required corporate action of LICENSEE and no other action on the part of LICENSEE is necessary to authorize the execution, delivery and performance of this Agreement by LICENSEE and the consummation of the transaction contemplated hereby. This Agreement has been duly executed and delivered by LICENSEE and is a valid and binding obligation of LICENSEE enforceable against it in accordance with its terms, except to the extent that its enforceability may be subject to applicable bankruptcy, insolvency, reorganization, moratorium and similar laws affecting the enforcement of creditors’ rights generally and by general equitable principles.
13.2 Authorization and Validity of Agreement . LICENSEE has full power and authority, including full corporate power and authority, to execute and deliver this Agreement, to perform its obligations hereunder and to consummate the transactions contemplated hereby. Without limiting the foregoing, the execution, delivery and performance of this Agreement by LICENSEE and the consummation by it of the transactions contemplated hereby, have been duly authorized and approved by the members and managers of LICENSEE, and no other action on the part of LICENSEE or its officers, directors or shareholder is necessary to authorize the execution, delivery and performance of this Agreement by LICENSEE and the consummation of the transactions contemplated hereby. This Agreement has been duly executed and delivered by LICENSEE and is a valid and binding obligation of LICENSEE enforceable against it in accordance with its terms, except to the extent that its enforceability may be subject to applicable bankruptcy, insolvency, reorganization, moratorium and similar laws affecting the enforcement of creditors’ rights generally and by general equitable principles.
13.3 Consents and Approvals; No Violations . The execution, delivery and performance of this Agreement by LICENSEE and the consummation by LICENSEE of the transactions contemplated hereby will not, with or without the giving of notice or the lapse of time or both: (a) violate, conflict with, or result in a breach or default under any provision of the organizational documents of LICENSEE; (b) violate any statute, ordinance, rule or regulation applicable to LICENSEE, (c) violate any order, judgment or decree of any court or of any governmental or regulatory body, agency or authority applicable to LICENSEE or by which any of the LICENSED TECHNOLOGY may be bound; or (d) require any filing by LICENSEE with, or require LICENSEE to obtain any permit, consent or approval of, or require LICENSEE to give any notice to, any governmental or regulatory body, agency or authority, except filings, if any, which may be required under the “Blue Sky” laws of Massachusetts or as may be required in the future to comply with governmental regulations governing the production and sale of products by LICENSEE as it conducts its business.
13.4 Survival of Representations and Warranties .
(a) Except as otherwise provided herein, notwithstanding any investigation at any time made by or on behalf of any Party hereto, the representations and warranties set forth herein and in any certificate delivered in connection herewith with respect to any of those representations and warranties will survive the Effective Date until the longer to occur of: (i) two (2) years or (ii) the expiration of the applicable statutes of limitation, including all periods of extension and tolling whereupon they will terminate and expire.

 

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(b) After a representation and warranty has expired, as provided in Subsection 13.4(a) , no claim for claims or costs may be made or prosecuted by any Person who would have been entitled to claims or costs on the basis of that representation and warranty prior to its termination and expiration, provided that no claim presented in writing for claims or costs to the Person or Persons from which or whom those damages are sought on the basis of that representation and warranty prior to its termination and expiration will be affected in any way by that termination and expiration.
ARTICLE 14 — LIMITATION OF LIABILITY
EXCEPT FOR ANY LIABILITY TO ANY THIRD PARTIES PURSUANT TO ARTICLE 8 OR TO A PARTY PURSUANT TO ARTICLES 12 AND 13 OF THIS AGREEMENT, IN NO EVENT SHALL LICENSOR OR LICENSEE OR THEIR, ITS DIRECTORS, OFFICERS, EMPLOYEES OR AFFILIATES BE LIABLE FOR INCIDENTAL OR CONSEQUENTIAL DAMAGES OF ANY KIND, INCLUDING ECONOMIC DAMAGE OR INJURY TO PROPERTY AND LOST PROFITS, REGARDLESS OF WHETHER LICENSOR OR LICENSEE SHALL BE ADVISED, SHALL HAVE OTHER REASON TO KNOW, OR IN FACT SHALL KNOW OF THE POSSIBILITY OF SUCH DAMAGES.
ARTICLE 15 — MISCELLANEOUS PROVISIONS
15.1 CORPORATE PARTNERSHIPS. In the event LICENSEE enters into a corporate partnership for the joint development of any of the LICENSED TECHNOLOGY, and LICENSEE sublicenses the LICENSED TECHNOLOGY to a third party, then payments required hereunder shall not include funds provided for sponsored research or equity investments by any third party so long as such payments do not constitute a majority of funds transferred by such third party. However if the sponsored research involves fees in excess of industry standard reimbursement for FTEs or equity investment in excess of fair market value, LICENSEE shall pay to LICENSOR a royalty on such excess fees calculated at the rates specified herein.
15.2 LICENSEE “REVERSE LICENSE” TO LICENSOR. LICENSEE agrees to license to LICENSOR on a non-exclusive basis for therapeutic uses in the treatment of blood and cardiovascular diseases the rights to any technology it currently owns or has licensed or develops or licenses in the future that is applicable to such diseases (excluding however the use of proprietary techniques now or hereafter developed by LICENSEE for the enhanced vascularization of transplanted cells or tissues). Such license shall provide for royalty payments at the same rate as LICENSEE’S royalty payments to LICENSOR hereunder as provided in Section 4.2(a). Such license will be sublicensable only once in a given field of use; or for the

 

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purpose of having products produced, made, or distributed; or in connection with a merger or consolidation of LICENSOR into another company or a sale of all or substantially all of the assets of LICENSOR. LICENSEE shall also have no obligations hereunder with respect to technology licenses it has or may acquire if such licenses restrict sublicensing in a manner inconsistent with this subparagraph. Such “Reverse License shall not apply to any rights acquired by LICENSEE under Section 15.18 hereof.
15.3 FUTURE TECHNOLOGY LICENSES. LICENSOR acknowledges that it is continuing to develop cell-based technology, the existence or significance of which it may not have disclosed to LICENSEE. Therefore, LICENSOR further agrees that in the event any of its technology now perfected or pending as of the date of this agreement but not specifically enumerated herein would inhibit or adversely affect the commercial use by LICENSEE of the PATENT RIGHTS in the field, LICENSOR shall waive any claim of infringement to the extent necessary to permit LICENSEE to continue the use of the PATENT RIGHTS under this Agreement. In addition, LICENSOR agrees to license to LICENSEE on a non-exclusive basis for uses in the FIELDS, including any rights acquired under Section 15.18 hereof, the rights to any technology it currently owns or has licensed or develops or licenses in the future that is applicable to such FIELDS (but specifically excluding applications involving the use of cells in the treatment of tumors where the primary use of the cells is the destruction or reduction of tumors and does not involve regeneration of tissue or organ function). Such license shall provide for royalty payments at the same rate as LICENSEE’S royalty to LICENSOR hereunder as provided in Section 4.2(a). Such license will be sublicensable only once in a given field of use; or for the purpose of having products produced, made, or distributed; or in connection with a merger or consolidation of LICENSEE into another company or a sale of all or substantially all of the assets of LICENSEE. LICENSOR shall also have no obligations hereunder with respect to technology licenses it has or may acquire if such licenses restrict sublicensing in a manner inconsistent with this subparagraph.
15.4 LICENSEE shall comply with all local, state, federal and international laws and regulations relating to the development, manufacture, use, provision, and sale of LICENSED PRODUCTS, LICENSED PROCESSES and LICENSED SERVICES. Without limiting the generality of the foregoing, LICENSEE agrees to comply with the following:
  a)   LICENSEE shall obtain all necessary approvals from the FDA, USDA, or any similar governmental authorities of any foreign jurisdiction in which LICENSEE intends to make, use, or sell LICENSED PRODUCTS or to perform LICENSED PROCESSES or LICENSED SERVICES.
 
  b)   LICENSEE shall comply fully with any and all applicable local, state, federal and international laws and regulations relating to the LICENSED PRODUCTS, LICENSED PROCESSES and LICENSED SERVICES, and the PATENT RIGHTS, in the TERRITORY, including without limitation all export or import regulations and rules now in effect or as may be issued from time to time by any governmental authority which has jurisdiction relating to the export of LICENSED PRODUCTS, LICENSED PROCESSES or

 

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      LICENSED SERVICES and any technology relating thereto. LICENSEE hereby gives written assurance that it will comply with all such import or export laws and regulations (including without limitation all Export Administration Regulations of the United States Department of Commerce), that it bears sole responsibility for any violation of such laws and regulations, and that it will indemnify, defend, and hold LICENSOR and the University harmless (in accordance with Article 8 ) for the consequences of any such violation.
  c)   To the extent that any invention claimed in the PATENT RIGHTS has been partially funded by the United States Government, and only to the extent required by applicable laws and regulations, LICENSEE agrees that any LICENSED PRODUCTS used or sold in the United States will be manufactured substantially in the United States or its territories. Current law provides that if a domestic manufacturer is not commercially feasible under the circumstances, LICENSOR and/or the University may seek a waiver of this requirement from the relevant federal agency on behalf of LICENSEE and, upon LICENSEE’S request, shall cooperate with LICENSEE in seeking such a waiver.
15.5 LICENSEE shall not create or incur or cause to be incurred or to exist any lien, encumbrance, pledge, charge, restriction or other security interest of any kind upon the PATENT RIGHTS, but may cause to be incurred or to exist a lien, encumbrance, pledge, charge, restriction or other security interest on its rights to the LICENSED TECHNOLOGY hereunder, provided such security interest does not affect LICENSOR’s rights to the LICENSED TECHNOLOGY, or any of LICENSOR’s rights under this Agreement.
15.6 Neither Party shall originate any publicity, news release or other public announcement (“Announcements”), written or oral, relating to this Agreement or the existence of an arrangement between the Parties, without the prior written approval of the other Party, which approval shall not be unreasonably withheld or delayed, except as otherwise required by law. Any references to the University in such Announcements shall be subject to the approval of the University. The foregoing notwithstanding, LICENSOR and LICENSEE shall have the right to make such Announcements without the consent of the other Party or the University, as applicable, in any prospectus, offering memorandum, or other document or filing required by applicable securities laws or other applicable law or regulation, provided that such Party shall have given the other Party or the University, as applicable, at least ten (10) days prior written notice of the proposed text for the purpose of giving the other Party or the University, as applicable, the opportunity to comment on such text.
15.7 No implied licenses are granted pursuant to the terms of this Agreement. No licensed rights shall be created by implication or estoppel.

 

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15.8 Nothing herein shall be deemed to constitute either Party as the agent or representative of the Party, or both parties as joint venturers or partners for any purpose. Each Party shall be an independent contractor, not an employee or partner of the other Party, and the manner in which each Party renders its services under this Agreement shall be within its sole discretion. Neither Party shall be responsible for the acts or omissions of the other Party, nor shall either Party have authority to speak for, represent or obligate the other Party in any way without prior written authority from the other Party.
15.9 To the extent commercially feasible, and consistent with prevailing business practices and applicable law, all LICENSED PRODUCTS sold pursuant to this Agreement will be marked with the number of each issued patent that applies to such LICENSED PRODUCTS.
15.10 This Agreement shall be construed, governed, interpreted and applied in accordance with the laws of the State of California, U.S.A. without regard to principles of conflicts of law thereof, except that questions affecting the construction and effect of any patent shall be determined by the law of the country in which the patent was granted.
15.11 The Parties hereto acknowledge that this Agreement sets forth the entire Agreement and understanding of the Parties hereto as to the subject matter hereof, and shall not be subject to any change or modification except by the execution of a written instrument signed by the Parties hereto.
15.12 The provisions of this Agreement are severable, and in the event that any provision of this Agreement shall be determined to be invalid or unenforceable under any controlling body of the law, such invalidity or unenforceability shall not in any way affect the validity or enforceability of the remaining provisions hereof.
15.13 The failure of either Party to assert a right hereunder or to insist upon compliance with any term or condition of this Agreement shall not constitute a waiver of that right or excuse a similar subsequent failure to perform any such term or condition by the other Party.
15.14 This Agreement may not be assigned by LICENSEE without the prior written consent of LICENSOR, which consent shall be granted or denied in LICENSOR’s sole discretion. LICENSOR may not assign this Agreement without the consent of LICENSEE, which consent shall not be unreasonably withheld or delayed, except that LICENSOR may assign this Agreement to an affiliate or to a successor in connection with the merger, consolidation, or sale of all or substantially all of its assets or that portion of its business to which this Agreement relates. Notwithstanding the foregoing to the contrary, this restriction on the assignment by LICENSEE of this Agreement shall not prevent the assignment of this Agreement in connection with a merger or consolidation of LICENSEE into another company or a sale of all or substantially all of the assets of LICENSEE, so long as the purchaser of the assets agrees to assume to any and all outstanding liabilities to LICENSOR under this Agreement, including but not limited to any outstanding amounts under the promissory note referred to in Section 4.1 .

 

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15.15 This Agreement has been prepared jointly and no rule of strict construction shall be applied against either Party. In this Agreement, the singular shall include the plural and vice versa and the word “including” shall be deemed to be followed by the phrase “without limitation.” The section headings contained in this Agreement are inserted for convenience only and shall not affect in any way the meaning or interpretation of this Agreement.
15.16 This Agreement may be executed in counterparts, each of which together shall constitute one and the same Agreement.
15.17 All rights and licenses granted under or pursuant to this Agreement by LICENSOR to LICENSEE are, and shall otherwise be deemed to be, for purposes of Paragraph 365(n) of the U.S. Bankruptcy Code (the “Code”), licenses to rights in “intellectual property” as defined in the Code. The Parties hereto agree that LICENSEE, as a LICENSEE of such rights under this Agreement, shall retain and may fully exercise all of its rights and elections under the Code. The Parties hereto further agree that, in the event of the commencement of a bankruptcy proceeding by or against LICENSOR including a proceeding under the Code, LICENSEE shall be entitled to a complete duplicate of (or complete access to, as appropriate) any such intellectual property and all embodiments of such intellectual property, including the PATENT RIGHTS and KNOW-HOW, and the same, if not already in LICENSEE’s possession, shall be promptly delivered to LICENSEE upon any such commencement of a bankruptcy proceeding upon written request therefore by LICENSEE.
15.18 In addition to the other rights granted herein, LICENSOR hereby grants to LICENSEE a 90 day right of negotiation with respect to any technology that would constitute LICENSED TECHNOLOGY if the FIELD included diseases related either to the heart or to neuro degenerative diseases (the “Added Fields”) prior to LICENSOR entering into any license relating to either of such Added Fields) with a third party. Such a 90 day period shall commence on the earlier of the 12 month anniversary of the Effective Date, or such date when LICENSOR notifies LICENSEE that it has opened negotiations with a third party or that a third party has made inquiry about such a license. If following the expiration of any such 90-day negotiation period LICENSEE and LICENSOR have not entered into a license for an Added Field, LICENSOR shall be free to enter into an exclusive or non-exclusive license for such Added Field with any third party. If LICENSOR enters into a non-exclusive license for an Added Field with a third party following the 90-day negotiating period hereunder, LICENSOR shall offer a non-exclusive license to LICENSEE on comparable terms as those entered into with such third party. LICENSEE shall then have 30 days to enter into such a nonexclusive license. If LICENSEE does not enter into such a license within said 30-day period, LICENSOR shall have no further obligations relating to the Added Field.
15.19 LICENSEE shall acknowledge LICENSOR as [co-marketer] through equal size lettering on the packaging of ACT ANIMAL CELL LINES.

 

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IN WITNESS WHEREOF, the Parties have duly executed this Agreement on the EFFECTIVE DATE.
ADVANCED CELL TECHNOLOGY, INC.
         
By:
       
 
       
Printed Name: Michael D. West, Ph.D.    
Title: President & Chief Executive Officer    
PACGEN CELLCO, LLC
         
By:
       
 
       
Printed Name: Kenneth Aldrich    
Title: Managing Member    

 

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EXHIBIT A
PATENT RIGHTS
( Reference Section 1.12 )
                 
Serial No.       Filing Date        
Patent No.   CO   Issue Date   Title   Assignee
08/935,052
6,235,970
  US   1997-09-22
2001-05-22
  CICM Cells and Non-Human Mammalian Embryos Prepared by Nuclear Transfer of a Proliferating Differentiated Cell or its Nucleus   UMASS
 
               
09/828,876
  US   2001-04-10   Cloning Using Donor Nuclei from Differentiated Fetal and Adult Cells   UMASS
 
               
PI9806872-5
  BR   1998-01-05   Cloning Using Donor Nuclei from Differentiated Fetal and Adult Cells   UMASS
 
               
6014598
0742363
  AU   1998-01-05
2002-01-03
  Cloning Using Donor Nuclei from Differentiated Fetal and Adult Cells   UMASS
 
               
98802794.1
  CN   1998-01-05   Cloning Using Donor Nuclei from Differentiated Fetal and Adult Cells   UMASS
 
               
2277192
  CA   1998-01-05   Cloning Using Donor Nuclei from Differentiated Fetal and Adult Cells   UMASS
 
               
336612
  NZ   1998-01-05   Cloning Using Donor Nuclei from Differentiated Fetal and Adult Cells   UMASS
 
               
9906464
  MX   1998-01-05   Cloning Using Donor Nuclei from Differentiated Fetal and Adult Cells   UMASS
 
               
10-530958
  JP   1998-01-05   Cloning Using Donor Nuclei from Differentiated Fetal and Adult Cells   UMASS
 
               
130829
  IL   1998-01-05   Cloning Using Donor Nuclei from Differentiated Fetal and Adult Cells   UMASS
 
               
98903349.3
  EP   1998-01-05   Cloning Using Donor Nuclei from Differentiated Fetal and Adult Cells   UMASS

 

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Serial No.       Filing Date        
Patent No.   CO   Issue Date   Title   Assignee
PCT/US00/29551
  WO   2000-10-27   Gynogenetic or Androgenetic Production of Pluripotent Cells and Cell Lines, and Use Thereof to Produce Differentiated Cells and Tissues   UMASS
 
               
10/374,512
  US   2003-02-27   Gynogenetic or Androgenetic Production of Pluripotent Cells and Cell Lines, and Use Thereof to Produce Differentiated Cells and Tissues   UMASS
 
               
60/161,987
  US   1999-10-28   Gynogenetic or Androgenetic Production of Pluripotent Cells and Cell Lines, and Use Thereof to Produce Differentiated Cells and Tissues   UMASS
 
               
518365
  NZ   2000-10-27   Gynogenetic or Androgenetic Production of Pluripotent Cells and Cell Lines, and Use Thereof to Produce Differentiated Cells and Tissues   UMASS
 
               
PA/a/2002/004233
  MX   2000-10-27   Gynogenetic or Androgenetic Production of Pluripotent Cells and Cell Lines, and Use Thereof to Produce Differentiated Cells and Tissues   UMASS
 
               
2001-533962
  JP   2000-10-27   Gynogenetic or Androgenetic Production of Pluripotent Cells and Cell Lines, and Use Thereof to Produce Differentiated Cells and Tissues   UMASS
 
               
149175
  IL   2000-10-27   Gynogenetic or Androgenetic Production of Pluripotent Cells and Cell Lines, and Use Thereof to Produce Differentiated Cells and Tissues   UMASS
 
               
2000000973905
  EP   2000-10-27   Gynogenetic or Androgenetic Production of Pluripotent Cells and Cell Lines, and Use Thereof to Produce Differentiated Cells and Tissues   UMASS
 
               
00816098.8
  CN   2000-10-27   Gynogenetic or Androgenetic Production of Pluripotent Cells and Cell Lines, and Use Thereof to Produce Differentiated Cells and Tissues   UMASS

 

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Serial No.       Filing Date        
Patent No.   CO   Issue Date   Title   Assignee
2,387,506
  CA   2000-10-27   Gynogenetic or Androgenetic Production of Pluripotent Cells and Cell Lines, and Use Thereof to Produce Differentiated Cells and Tissues   UMASS
 
               
BR 0015148-3
  BR   2000-10-27   Gynogenetic or Androgenetic Production of Pluripotent Cells and Cell Lines, and Use Thereof to Produce Differentiated Cells and Tissues   UMASS
 
               
12353/01
  AU   2000-10-27   Gynogenetic or Androgenetic Production of Pluripotent Cells and Cell Lines, and Use Thereof to Produce Differentiated Cells and Tissues   UMASS
 
               
Invention Disclosures
 
               
UMA 01-02*
          Reprogramming of Somatic Cell Nuclei in vitro for use in Nuclear Transplantation   UMASS
 
               
UMA 99-19*
          Reprogramming
Nuclear Function in
Somatic Cell
Cytoplasm
  UMASS
*   Including patents filed by parties other than LICENSOR based on these Invention Disclosures, the rights to which LICENSOR would get through the litigation described in Exhibit D.

 

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EXHIBIT B
(Reference Section 2.4)
[Date]
Advanced Cell Technology, Inc.
One Innovation Drive
Worcester, MA 01605
Attention: Michael D. West, Ph.D., President
University of Massachusetts
Office of the General Counsel
One Beacon Street, 26 th Floor
Boston, MA 02108
PacGen Cellco, LLC.
157 Surfview Dr.,
Pacific Palisades, CA 90272
Attention: Kenneth Aldrich
Re: Exclusive License Agreement dated                            , 2004 between Advanced Cell Technology, Inc. (“LICENSOR”) and PacGen Cellco, LLC (“LICENSEE”) (the “License Agreement”)
Reference is made to the License Agreement identified above.
LICENSOR, the University of Massachusetts (the “University”) and LICENSEE agree that, in the event the UMASS LICENSES (as defined in the License Agreement) expire or are terminated for any reason pursuant to the provisions of the UMASS LICENSE or otherwise, (i) LICENSEE will thereafter pay directly to the University any payments due to LICENSOR under the License Agreement which are reasonably attributable to the University technology or subject matter of the UMASS LICENSES, and (ii) promptly following such termination, the University and LICENSEE will enter into a direct license agreement reflecting the applicable terms of the License Agreement and the UMASS LICENSES. For the avoidance of doubt, the references to “Sublicensees” in Section 8.5 of the 1996 UMASS LICENSE shall not apply to LICENSEE and shall not be construed as vitiating the provisions of Section 2.5 of the License Agreement. LICENSOR and the University agree that the provisions of Section 2.2 of the 1996 UMASS LICENSE providing for the automatic assignment to the University of sublicenses granted by LICENSOR under said Section 2.2 shall not apply to the sublicense by LICENSOR to LICENSEE under the License Agreement, and that the provisions of Section 2.5 of the License Agreement shall govern in the event that the UMASS LICENSES are terminated. LICENSOR and the University agree that LICENSEE will not be bound by any amendment to the UMASS

 

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LICENSES that affects LICENSEE’s rights under the License Agreement in any material respects, unless LICENSEE agrees in writing to such amendment. Neither LICENSOR nor the University will not make any change or addition to, or otherwise amend, the UMASS LICENSES in any manner that materially adversely affects LICENSEE without the prior written consent of LICENSEE (such consent not to be unreasonably withheld or delayed).
ADVANCED CELL TECHNOLOGY, INC.
         
By:
       
 
       
Printed Name: Michael D. West, Ph.D.    
Title: President & Chief Executive Officer    
THE UNIVERSITY OF MASSACHUSETTS
         
By:
       
 
       
Printed Name:    
Title:    
PACGEN CELLCO, LLC
         
By:
       
 
       
Printed Name: Kenneth Aldrich    
Title: President    

 

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EXHIBIT C
THIS NOTE AND THE SECURITIES ISSUABLE UPON CONVERSION OF THIS NOTE HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “ACT”), OR UNDER THE SECURITIES LAWS OF APPLICABLE STATES. THESE SECURITIES ARE SUBJECT TO RESTRICTIONS ON TRANSFERABILITY AND RESALE AND MAY NOT BE TRANSFERRED OR RESOLD EXCEPT AS PERMITTED UNDER THE ACT AND THE APPLICABLE STATE SECURITIES LAWS PURSUANT TO REGISTRATION OR EXEMPTION THEREFROM.
FORM OF
CONVERTIBLE PROMISSORY NOTE
OF
PACGEN CELLCO LLC
 
$150,000.00   Made as of May 14, 2004
For value received, PacGen CellCo LLC , a California limited liability company (the “Company”), with principal offices at 157 Surfview Drive, Pacific Palisades, CA 90272, hereby promise to pay to Advanced Cell Technology, Inc., a Delaware corporation (“Holder”), or its registered assigns, the principal sum of One Hundred Fifty Thousand Dollars ($150,000) (the “Principal Amount”).
Unless earlier paid or converted, the unpaid Principal Amount shall be due and payable on June 1, 2007 (the “Maturity Date”). On the Maturity Date, the principal shall be (i) repaid by the Company in cash to the Holder or (ii) at the Holder’s election, converted into shares of Common Stock (as defined below) at the conversion rate set forth in Subsection 2(a) below based on a determination of the Conversion Price as of the Maturity Date made not later than 60 days following the Maturity Date by the Company’s Board of Managers, acting in good faith.
This Note is issued pursuant to that certain Exclusive License Agreement dated as of May 14, 2004 (the “License Agreement”), by and among the Company and Holder, and is subject to the provisions thereof.
The following is a statement of the rights of Holder and the conditions to which this Note is subject, and to which Holder hereof, by the acceptance of this Note, agrees:
  1.   Definitions. The following definitions shall apply for all purposes of this Note:

 

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“Common Stock” means shares of or units of or other interests (as the case may be) of common equity of the Company or its successors or assigns
“Company” means the “Company” as defined above and includes any corporation, which shall succeed to or assume the obligations of the Company under this Note.
“Conversion Price” means (i) in the case of a First Equity Financing, the price paid per share for the equity securities issued in such First Equity Financing; or (ii) in the case of an Acquisition Event (as defined below) the value of one share or unit of Common Stock based upon the portion of the aggregate sale price or merger or consolidation consideration which is available to the Company’s common equity holders in connection with such Acquisition Event; or (iii) on the Maturity, the value of one share or unit of Common Stock as determined in good faith by the Board of Managers.
“First Equity Financing” means a sale or series thereof, subsequent to the date of this Note, by the Company of equity securities in which the Company receives aggregate cash proceeds of at least $5,000,000 (not including conversion of the this Note) as result of investments made by one or more bona fide third party institutional or strategic investors in exchange for the sale of shares of capital stock of the Company.
“Holder” means any person who shall at the time be the registered holder of this Note.
“Maturity Date” means the date on which this Note is either repaid or converted in whole in accordance with the terms hereunder.
“Note” means this Secured Convertible Promissory Note.
“Series A Preferred Stock” means the class of equity securities issued by the Company in the First Equity Financing.
2. Interest .
The principal sum outstanding under this Note shall bear no interest unless not repaid at the Maturity Date, in which event it shall thereafter bear interest at a rate equal to the lesser of (a) ten percent (10%) per annum, or (b) the maximum non-usurious rate allowed under the laws of the State of California.

 

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3. Conversion .
a) Automatic Conversions. This Note shall be automatically converted into that number of shares of Series A Preferred Stock equal to the quotient of (a) the aggregate principal amount of this Note then outstanding divided by (b) the Conversion Price, under the following conditions:
i) Upon the consummation of the First Equity Financing;
ii) Immediately prior to the closing of any merger, sale or other consolidation of the Company or of any sale of all or substantially all assets of the Company which occurs prior to the First Equity Financing (an “Acquisition Event”). Notwithstanding the above, and only in the event that a conversion resulting from such Acquisition Event would result in a security not traded on a national stock exchange (including NASDAQ and NASDAQ small cap), upon written notice to the Company not later than 5 days after the consummation of the Acquisition Event and notice of the Acquisition Event to the Holder of the Note, the Holder may elect to receive payment in cash of the entire outstanding principal of this Note.
b.  Conversion Mechanics . Upon the effective date of any elective or automatic conversion of this Note, the outstanding principal of this Note shall be deemed converted into shares of Series A Preferred Stock or Common Stock automatically as of such effective date without any further action by the Holder and whether or not the Note is surrendered to the Company or its transfer agent. However, the Company shall not be obligated to issue certificates evidencing the shares of the Series A Preferred Stock or Stock issuable upon such elective or automatic conversion unless such Note is either delivered to the Company or its transfer agent, or the Holder notifies the Company or its transfer agent that such Note has been lost, stolen or destroyed and executes an agreement satisfactory to the Company to indemnify the Company from any loss incurred by it in connection with such Note.
4. Reservation of Stock. If at any time the number of shares of Common Stock or other securities issuable upon conversion of this Note shall not be sufficient to effect the conversion of this Note, the Company will take such corporate action as may be necessary to increase its authorized but unissued shares of Common Stock or other securities issuable upon conversion of this Note (and any securities of the Company that the Common Stock may convert into) as shall be sufficient for such purpose.
5. Covenants of the Company. The Company covenants to, and agrees with the Holder that prior to the Maturity Date, so long as the Notes are outstanding, with the following:
a) Organization, Standing Power. The Company is a limited liability company duly organized, validly existing and in good standing under the California Limited Liability Company Act (the “CLLCA”). The Company has all requisite power and authority to conduct its business as now being conducted under the CLLCA.

 

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b) Authority; Enforceability; No Conflict . The Company has all requisite power and authority under the CLLCA to issue this Note and to carry out its obligations hereunder. The issuance of this Note by the Company has been duly and validly authorized by all requisite proceedings on the part of the Company. This Note when executed and delivered by the Company is a valid and binding obligation of the Company, enforceable against the Company in accordance with its terms, except that (i) such enforcement may be subject to bankruptcy, insolvency, reorganization, moratorium, rehabilitation, liquidation, conservatorship, receivership or other similar laws now or hereafter in effect relating to creditors’ rights generally and (ii) the remedy of specific performance and injunctive and other forms of equitable relief may be subject to equitable defenses and to the discretion of the court before which any proceeding therefor may be brought. The execution and delivery of this Note by the Company does not, and the consummation by the Company of the transaction contemplated hereby and thereby will not result in or constitute: (i) a default, breach or violation of or under the limited liability agreement of the Company, (ii) the California Limited Liability Company Act or any applicable law or (iii) any material agreement to which the Company is a party.
6. No Rights or Liabilities as Shareholder. This Note does not by itself entitle the Holder to any voting rights or other rights as a shareholder of the Company. In the absence of conversion of this Note, no provisions of this Note, and no enumeration herein of the rights or privileges of the Holder, shall cause the Holder to be a shareholder of the Company for any purpose.
7. No Impairment. The Company will not, by amendment of its limited liability agreement, or through reorganization, consolidation, merger, dissolution, issue or sale of securities, sale of assets or any other voluntary action, willfully avoid or seek to avoid the observance or performance of any of the terms of this Note, but will at all times in good faith assist in the carrying out of all such terms and in the taking of all such action as may be necessary or appropriate in order to protect the rights of the Holder under this Note against wrongful impairment. Without limiting the generality of the foregoing, the Company will take all such action as may be necessary or appropriate in order that the Company may duly and validly issue fully paid and nonassessable shares of Common Stock upon the conversion of this Note.
8. Prepayment. The Company may at any time, without penalty, prepay in whole or in part the unpaid balance of this Note. All payments will first be applied to the repayment of accrued fees and expenses, if any, then to accrued interest, if any, until all then outstanding accrued interest has been paid, and then shall be applied to the repayment of principal.
9. Notice. The Company shall give the Holder of this Note at least ten (10) days notice of any Acquisition Event.
10. Waiver and Amendment. Any provision of this Note may be amended, waived or modified only upon written consent of the Company and the Holder of the Note.
11. Waiver of Notice and Fees. The Company and all endorsers of this Note hereby waive notice, presentment, protest and notice of dishonor.

 

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12. Transfer. This Note and any rights hereunder may not be assigned, conveyed or transferred, in whole or in part, without the Company’s prior written consent, which consent shall not be unreasonably withheld. The rights and obligations of the Company and the Holder under this Note and the License Agreement shall be binding upon and benefit their respective permitted successors, assigns, heirs, administrators and transferees. However, this Note and the loans evidenced hereby may be transferred in whole or in part only by registration of such transfer on the register maintained for such purpose by or on behalf of the Company.
13. Governing Law. This Note shall be governed by and construed under the internal laws of the State of Delaware, without reference to principles of conflict of laws or choice of laws.
14. Securities Law Representations. This Note is issued to the Holder in reliance upon the Holder’s representation to the Company, which by such Holder’s execution of this Note Holder hereby confirms, that the Note will be acquired for investment for such Holder’s own account, not as a nominee or agent, and not with a view to the sale or distribution of any part thereof, and that such Holder has no present intention of selling, granting any participation in, or otherwise distributing the same. By executing this Note, such Holder further represents that such Holder has no contract, undertaking, agreement or arrangement with any person to sell, transfer, of grant participations to such person or to any third person, with respect to this Note.
15. Headings. The headings and captions used in this Note are used only for convenience and are not to be considered in construing or interpreting this Note. All references in this Note to sections and exhibits shall, unless otherwise provided, refer to sections hereof and exhibits attached hereto, all of which exhibits are incorporated herein by this reference.
16. Severability. If one or more provisions of this Note are held to be unenforceable under applicable law, such provision(s) shall be excluded from this Note and the balance of the Note shall be interpreted as if such provision(s) were so excluded and shall be enforceable in accordance with its terms.
17. Entire Agreement; Successors and Assigns. This Note constitutes the entire contract between the Company and the Holder relative to the subject matter hereof. Any previous agreement between the Company and the Holder is superseded by this Agreement. Subject to the exceptions specifically set forth in this Note, the terms and conditions of this Note shall inure to the benefit of and be binding upon the respective executors, administrators, heirs, successors and assigns of the Parties.
[Remainder of this page intentionally left blank]

 

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IN WITNESS WHEREOF , the Company has caused this Note to be signed in its name as of the date first above written.
PACGEN CELLCO LLC
         
By:
  /S/ KENNETH ALDRICH
 
Name:
   
 
  Title: MANAGING MEMBER    
ACCEPTED AND AGREED TO:
ADVANCED CELL TECHNOLOGY, INC.
         
By:
  /S/ MICHAEL D. WEST
 
Name:
   
 
  Title: PRESIDENT    

 

 


 

EXHIBIT D
(Reference Section 12.3)
A civil action was filed by the University of Massachusetts on February 3, 2004 against James M. Robl and Philippe Collas relating to the misappropriation of intellectual property. Specifically the University of Massachusetts believes that invention disclosures UMA 99-19 and UMA 01-02 were misappropriated and wrongly assigned to third parties. This action is currently pending as of the signing of this license.

 

 


 

EXHIBIT E
(Reference Section 12.7)
Declared patent interferences:
a)   Patent Interference No. 104,746, involving U.S. Patent No. 5,945,577 and U.S. Patent Application No. 09/650,194.
 
b)   Patent Interference No. 105,192, involving U.S. Patent No. 6,235,970 and U.S. Patent Application No. 09/989,126.
Potential patent interferences, verbally threatened to be filed against the following patents:
a)   6,215,041
 
b)   6,235,969

 

 

 

Exhibit 10.15
INTERNATIONAL STEM CELL CORPORATION
2006 EQUITY PARTICIPATION PLAN

 

 


 

INTERNATIONAL STEM CELL CORPORATION
2006 EQUITY PARTICIPATION PLAN
TABLE OF CONTENTS
                     
 
                   
1.   Purpose .     1  
 
                   
2.   Definitions .     1  
 
                   
3.   Administration     4  
 
                   
 
    3.1.     Delegation of Administration     4  
 
    3.2.     Powers of the Committee     5  
 
    3.3.     Administration When Common Stock is Publicly Traded     6  
 
                   
4.   Eligibility .     6  
 
                   
 
    4.1.     Eligibility for Awards     6  
 
    4.2.     Eligibility of Consultants     6  
 
    4.3.     Limitation on Individual Awards     6  
 
    4.4.     Substitute Awards     7  
 
                   
5.   Common Stock Subject to Plan .     7  
 
                   
 
    5.1.     Share Reserve     7  
 
    5.2.     Reversion of Shares     7  
 
    5.3.     Source of Shares.     7  
 
                   
6.   Options .     7  
 
                   
 
    6.1.     Award     7  
 
    6.2.     Option Price     7  
 
    6.3.     Maximum Option Period     8  
 
    6.4.     Maximum Value of Options which are Incentive Stock Options     8  

 

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    6.5.     Nontransferability     8  
 
    6.6.     Vesting and Termination of Continuous Service     9  
 
    6.7.     Exercise     9  
 
    6.8.     Payment     10  
 
    6.9.     Buyout Provisions     10  
 
    6.10.     Shareholder Rights     10  
 
    6.11.     Disposition and Stock Certificate Legends for Incentive Stock Option Shares     10  
 
                   
7.   Restricted Stock Awards     11  
 
                   
 
    7.1.     Restricted Stock Awards     11  
 
                   
8.   Changes in Capital Structure and Change in Control .     12  
 
                   
 
    8.1.     No Limitations of Rights     12  
 
    8.2.     Changes in Capitalization     12  
 
    8.3.     Change in Control     12  
 
    8.4.     Limitation on Adjustment     13  
 
                   
9.   Withholding of Taxes .     14  
 
                   
10.   Compliance with Law and Approval of Regulatory Bodies     14  
 
                   
 
    10.1.     General Requirements     14  
 
    10.2.     Participant Representations     14  
 
                   
11.   General Provisions     15  
 
                   
 
    11.1.     Corporation Repurchase Rights     15  
 
    11.2.     Information to Participants     15  
 
    11.3.     Effect on Employment and Service     15  
 
    11.4.     Use of Proceeds     15  
 
    11.5.     Unfunded Plan     15  
 
    11.6.     Rules of Construction     15  
 
    11.7.     Choice of Law     15  
 
                   
12.   Amendment and Termination     16  
 
                   
13.   Effective Date of Plan, Duration of Plan     16  

 

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INTERNATIONAL STEM CELL CORPORATION
2006 EQUITY PARTICIPATION PLAN
1.  
Purpose .
The 2006 Equity Participation Plan (the “ Plan ”) of International Stem Cell Corporation (the “ Corporation ”) is intended to promote the best interests of the Corporation and its shareholders by: (i) assisting the Corporation and its Affiliates (as defined below) in the recruitment and retention of persons with ability and initiative; (ii) providing an incentive to such persons to contribute to the growth and success of the Corporation’s businesses by affording such persons equity participation in the Corporation; and (iii) associating the interests of such persons with those of the Corporation and its Affiliates and shareholders.
2.  
Definitions .
As used in the Plan, the following definitions shall apply:
Affiliate ” means (i) any Subsidiary; (ii) any Parent; (iii) any corporation, trade or business (including, without limitation, a partnership or limited liability company) which is directly or indirectly controlled fifty percent (50%) or more (whether by ownership of stock, assets or an equivalent ownership interest or voting interest) by the Corporation or one of its Affiliates; and (iv) any other entity in which the Corporation or any of its Affiliates has a material equity interest and which is designated as an “Affiliate” by resolution of the Committee.
Board ” means the Board of Directors of the Corporation.
Cause ” means (i) in the case where the Participant does not have an employment, consulting or similar agreement in effect with the Corporation or its Affiliate at the time of grant of the Option or Restricted Stock Award or where there is such an agreement but it does not define “cause” (or words of like import), conduct related to the Participant’s service to the Corporation or an Affiliate for which either criminal or civil penalties against the Participant may be sought, misconduct, insubordination, material violation of Corporation or its Affiliate’s policies, disclosing or misusing any confidential information or material concerning the Corporation or any Affiliate or material breach of any employment, consulting agreement or similar agreement; or (ii) in the case where the Participant has an employment agreement, consulting agreement or similar agreement in effect with the Corporation or its Affiliate at the time of grant of the Option or Restricted Stock Award that defines a termination for “cause” (or words of like import), “cause” as defined in such agreement; provided , however , that with regard to any agreement that defines “cause” on occurrence of or in connection with change of control, such definition of “cause” shall not apply until a change of control actually occurs and then only with regard to a termination thereafter.

 

 


 

Change in Control ” means: (i) the acquisition (other than from the Corporation) by any Independent Third Party of beneficial ownership of more than fifty percent (50%) of the outstanding voting securities of the Corporation; provided, however, a Change in Control shall not be deemed to occur solely because more than fifty percent (50%) of the outstanding voting securities of the Corporation is acquired by (a) a trustee or other fiduciary holding securities under one (1) or more employee benefit plans maintained by the Corporation or any of its Subsidiaries, or (b) any individual, corporation, partnership, limited liability company, association, joint-stock company, trust, unincorporated association or other entity which, immediately prior to such acquisition, is owned directly or indirectly by the shareholders of the Corporation in the same proportion as their ownership of the voting securities of the Corporation immediately prior to such acquisition; (ii) a merger, consolidation or other reorganization involving the Corporation if the shareholders of the Corporation, immediately before such merger, consolidation or other reorganization, do not, as a result of such merger, consolidation or other reorganization, own, directly or indirectly, more than fifty percent (50%) of the combined voting power of the then outstanding voting securities of the entity resulting from such merger, consolidation or other reorganization in substantially the same proportion as their ownership of the Common Stock outstanding immediately before such merger, consolidation or other reorganization, (iii) a complete liquidation or dissolution of the Corporation; or (iv) the sale or other disposition of all or substantially all of the assets of the Corporation and its Subsidiaries determined on a consolidated basis.
Change in Control Price ” means the highest of (i) if the Common Stock is traded on the NASDAQ Stock Market or is listed on a national securities exchange, the highest reported sales price, regular way, of a share of Common Stock in any transaction as reported on the NASDAQ Stock Market or other national securities exchange or market on which such shares are listed, as applicable, during the 60-day period prior to and including the date of a Change in Control; (ii) if the Change in Control is the result of a tender or exchange offer, merger or other corporate transaction, the highest price per share of Common Stock paid in such tender or exchange offer, merger or other corporate transaction; and (iii) the Fair Market Value of a share of Common Stock upon the Change in Control. To the extent that the consideration paid in any such transaction described above consists all or in part of securities or other non-cash consideration, the value of such securities or other non-cash consideration shall be determined in the sole discretion of the Committee. The Participant shall receive the same form of consideration pursuant to the transaction as holders of Common Stock, subject to the same restrictions and limitations and indemnification obligations as the holders of Common Stock, and will execute any and all documents required by the Committee to evidence the same.
Code ” means the Internal Revenue Code of 1986, and any amendments thereto.
Committee ” means the Board or any Committee of the Board to which the Board has delegated any responsibility for the implementation, interpretation or administration of the Plan.
Common Stock ” means the common stock of the Corporation.
Consultant ” means (i) any person performing consulting or advisory services for the Corporation or any Affiliate; or (ii) a director of an Affiliate.
Continuous Service ” means that the Participant’s service with the Corporation or an Affiliate, whether as an employee, Director or Consultant, is not interrupted or terminated. A Participant’s Continuous Service shall not be deemed to have terminated merely because of a change in the capacity in which the Participant renders service to the Corporation or an Affiliate as an employee, Consultant or Director or a change in the entity for which the Participant renders such service, provided that there is no interruption or termination of the Participant’s Continuous Service. The Participant’s Continuous Service shall be deemed to have terminated either upon an actual termination or upon the corporation for which the Participant is performing services ceasing to be an Affiliate of the Corporation. The Committee shall determine whether Continuous Service shall be considered interrupted in the case of any leave of absence approved by the Corporation, including sick leave, military leave or any other personal leave.

 

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Corporation Law ” means the general corporation law of the jurisdiction of incorporation of the Corporation.
Director ” means a member of the Board.
Disability ” shall have the meaning provided for in Section 22(e)(3) of the Code or any successor statute thereto.
Eligible Person ” means, as determined by the Committee, an employee of the Corporation or an Affiliate (including a corporation that becomes an Affiliate after the adoption of the Plan), a Director or a Consultant to the Corporation or an Affiliate (including a corporation that becomes an Affiliate after the adoption of the Plan).
Exchange Act ” means the Securities Exchange Act of 1934, as amended.
Fair Market Value ” means, on any given date, the current fair market value of a share of Common Stock as determined as follows:
(i) If the Common Stock is traded on The NASDAQ Stock Market or is listed on a national securities exchange, the closing price for the day of determination as quoted on such market or exchange which is the primary market or exchange for trading of the Common Stock or if no trading occurs on such date, the last day on which trading occurred, or such other appropriate date as determined by the Committee in its discretion, as reported in The Wall Street Journal or such other source as the Committee deems reliable;
(ii) If the Common Stock is regularly quoted by a recognized securities dealer but selling prices are not reported, its Fair Market Value shall be the mean between the high and the low asked prices for the Common Stock for the day of determination; or
(iii) In the absence of an established market for the Common Stock, Fair Market Value shall be determined by the Committee in good faith.
Fair Market Value shall be determined in accordance with Code Section 409A and the regulations and other applicable guidance issued thereunder.
Independent Third Party ” means any individual, corporation, partnership, limited liability company, association, joint-stock company, trust, unincorporated association or other entity who does not directly or indirectly own in excess of twenty percent (20%) of the outstanding Common Stock, who is not controlling, controlled by or under common control with any such twenty percent (20%) owner, and who is not the spouse or descendent (by birth or adoption) of any such twenty percent (20%) owner.
Incentive Stock Option ” means an Option (or portion thereof) intended to qualify for special tax treatment under Section 422 of the Code.
Listing Date ” means the date on which the Corporation has a class of equity securities registered under Section 12 of the Securities Act.

 

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Nonqualified Stock Option ” means an Option (or portion thereof) which is not intended to or for any reason does not qualify as an Incentive Stock Option.
Option ” means any option to purchase shares of Common Stock granted under the Plan.
Parent ” means any corporation (other than the Corporation) in an unbroken chain of corporations ending with the Corporation if each of the corporations (other than the Corporation) owns stock possessing at least fifty percent (50%) of the total combined voting power of all classes of stock in one of the other corporations in such chain.
Participant ” means an Eligible Person who is selected by the Committee to receive an Option or Restricted Stock Award and is party to a Stock Option Agreement or Restricted Stock Agreement.
Plan ” means this International Stem Cell Corporation 2006 Equity Participation Plan.
Restricted Stock Award ” means an award of Common Stock under Section 7.1 .
Securities Act ” means the Securities Act of 1933, as amended.
Restricted Stock Agreement ” means an agreement (written or electronic) between the Corporation and a Participant setting forth the specific terms and conditions of a Restricted Stock Award granted to the Participant under Section 7 . Each Restricted Stock Agreement shall be subject to the terms and conditions of the Plan and shall include such terms and conditions as the Committee shall authorize.
Stock Option Agreement ” means an agreement (written or electronic) between the Corporation and a Participant setting forth the specific terms and conditions of an Option granted to the Participant. Each Stock Option Agreement shall be subject to the terms and conditions of the Plan and shall include such terms and conditions as the Committee shall authorize.
Subsidiary ” means any corporation (other than the Corporation) in an unbroken chain of corporations beginning with the Corporation if each of the corporations (other than the last corporation in the unbroken chain) owns stock possessing at least fifty percent (50%) of the total combined voting power of all classes of stock in one of the other corporations in such chain.
Ten Percent Owner ” means any Eligible Person owning at the time an Option or Restricted Stock Award is granted more than ten percent (10%) of the total combined voting power of all classes of stock of the Corporation or of an Affiliate. An individual shall be considered to own any voting stock owned (directly or indirectly) by or for his brothers, sisters, spouse, ancestors and lineal descendants and any voting stock owned (directly or indirectly) by or for a corporation, partnership, estate or trust shall be considered as being owned proportionately by or for its shareholders, partners or beneficiaries.
3.  
Administration .
3.1. Delegation of Administration . The Board shall serve as the Committee of the Plan unless the Board delegates all or any portion of its authority to administer the Plan to a Committee. To the extent not prohibited by the charter or bylaws of the Corporation, the Board may delegate all or a portion of its authority to administer the Plan to a Committee of the Board appointed by the Board and constituted in compliance with the applicable Corporation Law.

 

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3.2. Powers of the Committee . Subject to the provisions of the Plan and, in the case of a Committee appointed by the Board, the specific duties delegated to such Committee, the Committee shall have the authority:
(i) to construe and interpret all provisions of the Plan and all Stock Option Agreements and Restricted Stock Agreements under the Plan;
(ii) to determine the Fair Market Value of Common Stock;
(iii) to select the Eligible Persons to whom Options or Restricted Stock Awards are granted from time to time hereunder;
(iv) to determine the number of shares of Common Stock covered by an Option or Restricted Stock Award; determine whether an Option shall be an Incentive Stock Option or Nonqualified Stock Option; and determine such other terms and conditions, not inconsistent with the terms of the Plan, of each such Option or Restricted Stock Award. Such terms and conditions include, but are not limited to, the exercise price of an Option, the purchase price of Common Stock subject to a Restricted Stock Award, the time or times when Options or Restricted Stock Awards may be exercised or Common Stock issued thereunder, the right of the Corporation to repurchase Common Stock issued pursuant to the exercise of an Option or a Restricted Stock Award and other restrictions or limitations (in addition to those contained in the Plan) on the forfeitability or transferability of Options, Restricted Stock Awards or Common Stock issued upon exercise of an Option or pursuant to a Restricted Stock Award. Such terms may include conditions as determined by the Committee and need not be uniform with respect to Participants;
(v) to accelerate the time at which any Option or Restricted Stock Award may be exercised, or the time at which a Restricted Stock Award or Common Stock issued under the Plan may become transferable or non-forfeitable; provided that the time of exercise of any Option that is subject to Code Section 409A may not be accelerated;
(vi) to determine whether and under what circumstances an Option may be settled in cash, shares of Common Stock and/or other property under Section 6.1 ;
(vii) to amend, cancel, extend, renew, accept the surrender of, modify or accelerate the vesting of or lapse of restrictions on all or any portion of an outstanding Option or Restricted Stock Award and reduce the exercise price of any Option, provided that any action taken pursuant to this Section 3.2(vii) with respect to an Option shall be taken only to the extent that such action would not violate Code Section 409A or prevent the Plan or the Option from qualifying for an exemption under Code Section 409A. Except as specifically permitted by the Plan, Stock Option Agreement or Restricted Stock Agreement or as required to comply with applicable law, regulation or rule, no amendment, cancellation or modification shall, without a Participant’s consent, adversely affect any rights of the Participant; provided , however , that an amendment or modification that may cause an Incentive Stock Option to become a Nonqualified Stock Option shall not be treated as adversely affecting the rights of the Participant; and

 

- 5 -


 

(viii) to prescribe the form of Stock Option Agreements and Restricted Stock Agreements; to adopt policies and procedures for the exercise of Options and Restricted Stock Awards, including the satisfaction of withholding obligations, and the authority to adopt, amend, and rescind policies and procedures pertaining to the administration of the Plan and make all other determinations necessary or advisable for the administration of the Plan.
The express grant in the Plan of any specific power to the Committee shall not be construed as limiting any power or authority of the Committee; provided , however , that a Committee of the Board may not exercise any right or power reserved to the Board. Any decision made, or action taken, by the Committee or in connection with the administration of the Plan shall be final, conclusive and binding on all persons having an interest in the Plan.
3.3. Administration When Common Stock is Publicly Traded . On and following the Listing Date the Committee authorized by the Board to administer the Plan shall, if so determined by the Board, consist of solely two (2) or more Non-Employee Directors (within the meaning of Rule 16b-3 under the Exchange Act) and/or two (2) or more persons who qualify as Outside Directors (within the meaning of Treasury Regulations under Section 162(m) of the Code); provided , however , that the Board may delegate administrative authority with respect to Eligible Persons who are not subject to Section 16 of the Exchange Act to a committee of other than Non-Employee Directors and/or to a committee of other than Outside Directors if either the Board decides not to comply with Section 162(m) or such authority is limited to Eligible Persons who are not then and are not reasonably expected to become Covered Employees (within the meaning of Section 162(m) of the Code).
4.  
Eligibility .
4.1. Eligibility for Awards . Nonqualified Stock Options and Restricted Stock Awards may be granted to any Eligible Person selected by the Committee. Incentive Stock Options may be granted only to employees of the Corporation or a Parent or Subsidiary.
4.2. Eligibility of Consultants . A Consultant shall be an Eligible Person only if the offer or sale of the Corporation’s securities would be exempt from registration under Rule 701 under the Securities Act prior to the date the Corporation is required to file reports under Section 13 or 15(d) of the Exchange Act, or eligible for registration on Form S-8 Registration Statement, on and following the date the Corporation is required to file reports under Section 13 or 15(d) of the Exchange Act, because, in either case, of the identity and nature of the service provided by such person, unless the Corporation determines that an offer or sale of the Corporation’s securities to such person satisfies another exemption from registration under the Securities Act and complies with the security laws of all other jurisdictions applicable to such offer or sale.
4.3. Limitation on Individual Awards . Following the effective date of this Section as provided below and subject to adjustment in accordance with Section 8 of the Plan, no employee shall during any calendar year be granted Options or Restricted Stock Awards for more than Five Million (5,000,000) shares of Common Stock. The limitation of this Section 4.3 shall apply following the Listing Date and upon the earlier of (i) a material modification of the Plan; (ii) the first meeting of shareholders at which directors are elected and which occurs after the close of the third (3 rd ) calendar year following the calendar year during which occurs the first registration of the Corporation’s equity securities under Section 12 of the Securities Act; or (iii) such date as is required to comply with Section 162(m) of the Code and regulations thereunder.

 

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4.4. Substitute Awards . The Committee may make Restricted Stock Awards and may grant Options under the Plan by assumption, substitution or replacement of performance shares, phantom shares, stock awards, stock options, stock appreciation rights or similar awards granted by another company (including an Affiliate), if such assumption, substitution or replacement is in connection with an asset acquisition, merger, consolidation or similar transaction involving the Corporation (and/or its Affiliate) and such other company (and/or its affiliate). Notwithstanding any provision of the Plan (other than the maximum number of shares of Common Stock that may be issued under the Plan), the terms of such assumed, substituted or replaced Restricted Stock Awards or Options shall be as the Committee, in its discretion, determines is appropriate.
5.  
Common Stock Subject to Plan .
5.1. Share Reserve . Subject to adjustment as provided in Section 8 , the maximum aggregate number of shares of Common Stock that may be (i) issued under the Plan pursuant to the exercise of Options; and (ii) issued pursuant to Restricted Stock Awards is Fifteen Million (15,000,000) shares. At no time shall the total number of securities issuable upon the exercise of all outstanding options and the total number of shares provided for under any stock bonus or similar plan or agreement of the Corporation exceed the applicable percentage as calculated in accordance with the conditions and exclusions of Reg. 260.140.45 of the California Code of Regulations, based on the securities of the Corporation which are outstanding at the time the calculation is made.
5.2. Reversion of Shares . If an Option or Restricted Stock Award is terminated, expires or becomes unexercisable, in whole or in part, for any reason, the unissued or unpurchased shares of Common Stock which were subject thereto shall become available for future grant under the Plan. Shares of Common Stock that have been actually issued under the Plan shall not be returned to the share reserve for future grants under the Plan, except that shares of Common Stock issued pursuant to a Restricted Stock Award which are repurchased by the Corporation at the original purchase price of such shares shall be returned to the share reserve for future grant under the Plan.
5.3. Source of Shares . Common Stock issued under the Plan may be shares of authorized and unissued Common Stock or shares of previously issued Common Stock that have been reacquired by the Corporation.
6.  
Options .
6.1. Award . In accordance with the provisions of Section 4 above, the Committee shall designate each Eligible Person to whom an Option is to be granted and shall specify the number of shares of Common Stock covered by such Option. The Stock Option Agreement shall specify whether the Option is an Incentive Stock Option or Nonqualified Stock Option, the vesting schedule applicable to such Option and any other terms of such Option. No Option that is intended to be an Incentive Stock Option shall be invalid for failure to qualify as an Incentive Stock Option.
6.2. Option Price . The exercise price per share for Common Stock subject to an Option shall be determined by the Committee, but shall comply with the following:
(i) Unless otherwise determined by the Committee, the exercise price per share for Common Stock subject to a Nonqualified Stock Option:
(a) granted to a Participant who is deemed to be a Ten Percent Owner on the date such option is granted, shall not be less than one hundred ten percent (110%) of the Fair Market Value on the date of grant; and

 

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(b) granted to any other Participant, shall not be less than one hundred percent (100%) of the Fair Market Value on the date of grant.
(ii) The exercise price per share for Common Stock subject to an Incentive Stock Option:
(a) granted to a Participant who is deemed to be a Ten Percent Owner on the date such option is granted, shall not be less than one hundred ten percent (110%) of the Fair Market Value on the date of grant; and
(b) granted to any other Participant, shall not be less than one hundred percent (100%) of the Fair Market Value on the date of grant.
6.3. Maximum Option Period . The maximum period during which an Option may be exercised shall be determined by the Committee on the date of grant, except that no Option shall be exercisable after the expiration of ten years from the date such Option was granted. In the case of an Incentive Stock Option that is granted to a Participant who is or is deemed to be a Ten Percent Owner on the date of grant, such Option shall not be exercisable after the expiration of five years from the date of grant. The terms of any Option may provide that it is exercisable for a period less than such maximum period.
6.4. Maximum Value of Options which are Incentive Stock Options . To the extent that the aggregate Fair Market Value of the Common Stock with respect to which Incentive Stock Options granted to any person are exercisable for the first time during any calendar year (under all stock option plans of the Corporation or any of its Affiliates) exceeds One Hundred Thousand Dollars ($100,000) (or such other amount provided in Section 422 of the Code), the Options are not Incentive Stock Options. For purposes of this Section 6.4 , the Fair Market Value of the Common Stock shall be determined as of the time the Incentive Stock Option with respect to the Common Stock is granted. This Section 6.4 shall be applied by taking Incentive Stock Options into account in the order in which they are granted.
6.5. Nontransferability . Options granted under the Plan which are intended to be Incentive Stock Options shall be nontransferable except by will or by the laws of descent and distribution and during the lifetime of the Participant shall be exercisable by only the Participant to whom the Incentive Stock Option is granted. Nonqualified Stock Options granted under the Plan shall be nontransferable except by will or by the laws of descent and distribution or, if the Stock Option Agreement so provides or the Committee so approves, as permitted by Rule 701 of the Securities Act, with respect to transfers by a Participant to the Participant’s family members, provided, however, that the Participant may not receive any consideration for the transfer. The holder of an Option transferred pursuant to this Section 6.5 shall be bound by the same terms and conditions that governed the Option during the period that it was held by the Participant. Except to the extent transferability of a Nonqualified Stock Option is provided for in the Stock Option Agreement or is approved by the Committee, during the lifetime of the Participant to whom the Nonqualified Stock Option is granted, such Option may be exercised only by the Participant. No right or interest of a Participant in any Option shall be liable for, or subject to, any lien, obligation, or liability of such Participant.

 

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6.6. Vesting and Termination of Continuous Service . The following rules shall apply:
(i) Options shall vest as provided in the Stock Option Agreement, provided that Options granted to Eligible Persons other than officers, Directors and Consultants shall vest at a rate of at least twenty percent (20%) per year over five (5) years from the date the Option is granted subject to reasonable conditions such as continued employment. An Option shall be exercisable only to the extent that it is vested on the date of exercise. Except as provided in the Stock Option Agreement, vesting of an Option shall cease on the date of the Participant’s termination of Continuous Service and the Option shall be exercisable only to the extent the Option is vested on the date of termination of Continuous Service;
(ii) If the Participant’s termination of Continuous Service is due to death or Disability, the Participant may exercise the Option as set forth in the Stock Option Agreement, provided that the right to exercise the Option (to the extent vested) shall expire six (6) months after the date of the Participant’s termination of Continuous Service, but in no event later than the tenth (10th) anniversary of the effective date of the Stock Option Agreement. Until the expiration date, the Participant’s heirs, legatees or legal representative may exercise the Option, except to the extent the Option was previously transferred pursuant to Section 6.5 ;
(iii) If the Participant’s termination of Continuous Service is an involuntary termination by the Corporation without Cause, or a voluntary termination by the Participant with Cause, the Participant may exercise the vested portion of the Option as set forth in the Stock Option Agreement, provided that the right to exercise the Option (to the extent that it is vested) shall expire ninety (90) days after the date of the Participant’s termination of Continuous Service, but in no event later than the tenth (10th) anniversary of the effective date of the Stock Option Agreement. If the Participant’s termination of Continuous Service is an involuntary termination without Cause or a voluntary termination with cause, and the Participant dies after his or her termination of Continuous Service but before the right to exercise the Option has expired, the right to exercise the Option (to the extent vested) shall expire six (6) months after the date of the Participant’s termination of Continuous Service, but in no event later than the tenth (10th) anniversary of the effective date of the Stock Option Agreement, and, until expiration, the Participant’s heirs, legatees or legal representative may exercise the Option, except to the extent the Option was previously transferred pursuant to Section 6.5 ; and
(iv) Unless otherwise provided in the Stock Option Agreement, if the Participant’s termination of Continuous Service is: (a) for Cause by the Corporation; (2) voluntary by the Participant without Cause; or (3) voluntary by the Participant after an event which would be grounds for termination by the Corporation of the Participant’s Continuous Service for Cause, then the right to exercise the Option shall expire as of the date of the Participant’s termination of Continuous Service.
6.7. Exercise . An Option shall be exercised by completion, execution and delivery of a notice of exercise (written or electronic) to the Corporation which states: (i) the Option holder’s intent to exercise the Option; (ii) the number of shares of Common Stock with respect to which the Option is being exercised; (iii) such other representations and agreements as may be required by the Corporation; and (iv) the method for satisfying any applicable tax withholding as provided in Section 9 . Such notice of exercise shall be provided on such form or by such method as the Committee may designate, and payment of the exercise price shall be made in accordance with Section 6.8 . Subject to the provisions of the Plan and the applicable Stock Option Agreement, an Option may be exercised to the extent vested in whole at any time or in part from time to time at such times and in compliance with such requirements as the Committee shall determine. A partial exercise of an Option shall not affect the right to exercise the Option from time to time in accordance with the Plan and the applicable Stock Option Agreement with respect to the remaining shares subject to the Option. An Option may not be exercised with respect to fractional shares of Common Stock.

 

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6.8. Payment . Unless otherwise provided by the Stock Option Agreement, payment of the exercise price for an Option shall be made in cash or a cash equivalent acceptable to the Committee. With the consent of the Committee, payment of all or part of the exercise price of an Option may also be made (i) by surrendering shares of Common Stock to the Corporation that have been held for at least six (6) months prior to the date of exercise; (ii) with a full-recourse promissory note until such time as the Corporation has a class of equity securities registered under Section 12 of the Securities Act; (iii) if the Common Stock is traded on an established securities market, the Committee may approve payment of the exercise price by a broker-dealer or by the Option holder with cash advanced by the broker-dealer if the exercise notice is accompanied by the Option holder’s written irrevocable instructions to deliver the Common Stock acquired upon exercise of the Option to the broker-dealer; or (iv) any other method acceptable to the Committee and in compliance with applicable laws. If Common Stock is used to pay all or part of the exercise price, the sum of the cash or cash equivalent and the Fair Market Value (determined as of the date of exercise) of the shares surrendered must not be less than the Option price of the shares for which the Option is being exercised. If all or part of the exercise price is to be paid with a full-recourse promissory note, the shares received upon exercise of the Option shall be pledged as security for payment of the principal amount of the promissory note and interest thereon and the interest rate payable under the terms of the promissory note shall not be less than the minimum rate (if any) required to avoid the imputation of additional interest under the Code. Subject to the foregoing, the Committee (at its sole discretion) shall specify the term, interest rate, amortization requirements (if any) and other provisions of such note.
6.9. Buyout Provisions . The Committee may at any time offer to buy out an Option previously granted for a payment in cash, shares of Common Stock or other property. Such buyout offer shall be on such terms and conditions as the Committee shall determine.
6.10. Shareholder Rights . No Participant shall have any rights as a shareholder with respect to shares subject to an Option until the date of exercise of such Option and the certificate for shares of Common Stock to be received on exercise of such Option has been issued by the Corporation. Voting rights of Common Stock issued pursuant to the Plan shall comply with Reg. 260.140.1 of the California Code of Regulations.
6.11. Disposition and Stock Certificate Legends for Incentive Stock Option Shares . A Participant shall notify the Corporation of any sale or other disposition of Common Stock acquired pursuant to an Incentive Stock Option if such sale or disposition occurs (i) within two (2) years of the grant of an Option; or (ii) within one (1) year of the issuance of the Common Stock to the Participant. Such notice shall be in writing and directed to the Secretary of the Corporation. The Corporation may require that certificates evidencing shares of Common Stock purchased upon the exercise of an Incentive Stock Option issued under the Plan be endorsed with a legend in substantially the following form:

 

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THE SHARES EVIDENCED BY THIS CERTIFICATE MAY NOT BE SOLD OR TRANSFERRED PRIOR TO ___, 20___, IN THE ABSENCE OF A WRITTEN STATEMENT FROM THE CORPORATION TO THE EFFECT THAT THE CORPORATION IS AWARE OF THE FACTS OF SUCH SALE OR TRANSFER.
The blank lines contained in this legend shall be filled in with the date that is the later of (i) one (1) year and one (1) day after the date of the exercise of such Incentive Stock Option; or (ii) two (2) years and one (1) day after the grant of such Incentive Stock Option.
7.  
Restricted Stock Awards .
7.1. Restricted Stock Awards . Each Restricted Stock Agreement for a Restricted Stock Award shall be in such form and shall contain such terms and conditions as the Committee shall deem appropriate. The terms and conditions of the Restricted Stock Agreements for Restricted Stock Awards may change from time to time, and the terms and conditions of separate Restricted Stock Awards need not be identical, but each Restricted Stock Award shall include (through incorporation of the provisions hereof by references in the agreement or otherwise), unless the Committee otherwise provides, the substance of each of the following provisions.
(i)  Purchase Price . Unless otherwise determined by the Committee, the purchase price of Restricted Stock Awards:
(a) granted to a Participant who is deemed to be a Ten Percent Owner on the date of granted, shall be one hundred percent (100%) of the Fair Market Value either on the date of grant (if the Restricted Stock Award is an outright grant to the Participant) or at the time the purchase is consummated (if the Restricted Stock Award requires the Participation to purchase the shares subject to the Restricted Stock Award); and
(b) granted to any other Participant, shall not be less than eighty-five percent (85%) of the Fair Market Value on the date of grant (if the Restricted Stock Award in an outright grant to the Participant) or at the time the purchase is consummated (if the Restricted Stock Award requires the Participant to purchase the shares subject to the Restricted Stock Award).
(ii)  Consideration . The purchase price of Common Stock acquired pursuant to the Restricted Stock Award shall be paid either (a) in cash at the time of purchase; (b) at the discretion of the Committee, according to a deferred payment or other similar arrangement with the Participant; or (c) in any other form of legal consideration that may be acceptable to the Committee in its discretion.
(iii)  Vesting . Shares of Common Stock acquired under a Restricted Stock Award may, but need not, be subject to a vesting schedule and may, but need not, be subject to a share repurchase option in favor of the Corporation as determined by the Committee.
(iv)  Participant’s Termination of Service . In the event of a Participant’s termination of Continuous Service, the Corporation may repurchase or otherwise reacquire any or all of the shares of Common Stock held by the Participant which have not vested as of the date of termination under the terms of the Restricted Stock Agreement for such Restricted Stock Award, subject to Section 11.1 .

 

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(v)  Nontransferability . Rights to acquire shares of Common Stock under a Restricted Stock Award shall be nontransferable except by will or by the laws of descent and distribution or, if the Restricted Stock Agreement so provides or the Committee so approves, as permitted by Rule 701 of the Securities Act, with respect to transfers by a Participant to the Participant’s family members; provided, however, that the Participant may not receive any consideration for the transfer.
8.  
Changes in Capital Structure and Change in Control .
8.1. No Limitations of Rights . The existence of outstanding Options or Restricted Stock Awards shall not affect in any way the right or power of the Corporation or its shareholders to make or authorize any or all adjustments, recapitalizations, reorganizations or other changes in the Corporation’s capital structure or its business, or any merger or consolidation of the Corporation, or any issuance of bonds, debentures, preferred or prior preference stock ahead of or affecting the Common Stock or the rights thereof, or the dissolution or liquidation of the Corporation, or any sale or transfer of all or any part of its assets or business, or any other corporate act or proceeding, whether of a similar character or otherwise.
8.2. Changes in Capitalization . If the Corporation effects a subdivision or consolidation of shares or other capital readjustment, the payment of a stock dividend or other increase or reduction of the number of shares of the Common Stock outstanding, or a combination, reclassification or other distribution of shares, without receiving consideration therefor in money, services or property, then (i) the number, class, and per share price of shares of Common Stock subject to outstanding Options and Restricted Stock Awards hereunder; and (ii) the number and class of shares then reserved for issuance under the Plan and the maximum number of shares for which awards may be granted to a Participant during a specified time period shall be appropriately and proportionately adjusted. The conversion of convertible securities of the Corporation shall not be treated as having been effected “without receiving consideration.” No substitution or adjustment made pursuant to this Section 8.2 shall be made to the extent that such substitution or adjustment would violate Code Section 409A or prevent the Plan from qualifying from exemption under Code Section 409A. The Committee shall make such adjustments, and its determinations shall be final, binding and conclusive.
8.3. Change in Control . Notwithstanding any other provision of the Plan to the contrary, except to the extent otherwise provided in an agreement granting an Option or a Restricted Stock Award, in the event of a Change in Control:
(i) The Committee shall have the discretion to accelerate the vesting of any Options and Restricted Stock Awards outstanding, but not fully vested and exercisable as of the date of such Change in Control, to the extent it deems appropriate;
(ii) The Committee shall have the discretion to remove all restrictions applicable to any outstanding Restricted Stock Awards, the effect of which shall be that the Common Stock relating to such Restricted Stock Awards shall become fully vested and transferable;
(iii) The Committee shall have the discretion to terminate any outstanding repurchase rights of the Corporation with respect to any outstanding Options and Restricted Stock Awards; and

 

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(iv) Outstanding Options and Restricted Stock Awards shall be subject to any agreement of merger or reorganization that effects such Change in Control, which agreement shall provide for:
(a) The continuation of the outstanding Options and Restricted Stock Awards by the Corporation, if the Corporation is a surviving corporation;
(b) The assumption of the outstanding Options and Restricted Stock Awards by the surviving corporation or its parent or subsidiary;
(c) The substitution by the surviving corporation or its parent or subsidiary of equivalent awards for the outstanding Options and Restricted Stock Awards; or
(d) Settlement of each share of Common Stock subject to an outstanding Option or Restricted Stock Award for the Change in Control Price (less, to the extent applicable, the per share exercise price), or, if the per share exercise price equals or exceeds the Change in Control Price, the outstanding Option or Restricted Stock Award, as applicable, shall terminate and be canceled.
(v) In the absence of any agreement of merger or reorganization effecting such Change in Control, each share of Common Stock subject to an outstanding Option or Restricted Stock Award shall be settled for the Change in Control Price (less, to the extent applicable, the per share exercise price), or, if the per share exercise price equals or exceeds the Change in Control Price, the outstanding Option or Restricted Stock Award shall terminate and be canceled.
No substitution or adjustment made pursuant to this Section 8.3 shall be made to the extent that such substitution or adjustment would violate Code Section 409A or prevent the Plan from qualifying from exemption under Code Section 409A.
8.4. Limitation on Adjustment . Except as previously expressly provided, neither the issuance by the Corporation of shares of stock of any class, or securities convertible into shares of stock of any class, for cash or property, or for labor or services either upon direct sale or upon the exercise of rights or warrants to subscribe therefor, or upon conversion of shares or obligations of the Corporation convertible into such shares or other securities, nor the increase or decrease of the number of authorized shares of stock, nor the addition or deletion of classes of stock, shall affect, and no adjustment by reason thereof shall be made with respect to, the number, class or price of shares of Common Stock then subject to outstanding Options or Restricted Stock Awards. No adjustment made pursuant to this Section 8.4 shall be made to the extent that such adjustment would violate Code Section 409A or prevent the Plan from qualifying from exemption under Code Section 409A.

 

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9.  
Withholding of Taxes .
The Corporation shall have the right, before any certificate for any Common Stock is delivered, to deduct or withhold from any payment owed to a Participant any amount that is necessary in order to satisfy any withholding requirement that the Corporation in good faith believes is imposed upon it in connection with federal, state, or local taxes, including transfer taxes, as a result of the issuance of, or lapse of restrictions on, such Common Stock, or otherwise require such Participant to make provision for payment of any such withholding amount. Subject to such conditions as may be established by the Committee, the Committee may permit a Participant to (i) have Common Stock otherwise issuable under an Option or Restricted Stock Award withheld to the extent necessary to comply with minimum statutory withholding rate requirements for supplemental income; (ii) tender back to the Corporation shares of Common Stock received pursuant to an Option or Restricted Stock Award to the extent necessary to comply with minimum statutory withholding rate requirements for supplemental income; (iii) deliver to the Corporation previously acquired Common Stock; (iv) have funds withheld from payments of wages, salary or other cash compensation due the Participant; or (v) pay the Corporation in cash, in order to satisfy part or all of the obligations for any taxes required to be withheld or otherwise deducted and paid by the Corporation with respect to the Option or Restricted Stock Award.
10.  
Compliance with Law and Approval of Regulatory Bodies .
10.1. General Requirements . No Option or Restricted Stock Award shall be exercisable, no Common Stock shall be issued, no certificates for shares of Common Stock shall be delivered, and no payment shall be made under the Plan except in compliance with all applicable federal and state laws and regulations (including, without limitation, withholding tax requirements), any listing agreement to which the Corporation is a party, and the rules of all domestic stock exchanges or quotation systems on which the Corporation’s shares may be listed. The Corporation shall have the right to rely on an opinion of its counsel as to such compliance. Any share certificate issued to evidence Common Stock when a Restricted Stock Award is granted or for which an Option or Restricted Stock Award is exercised may bear such legends and statements as the Committee may deem advisable to ensure compliance with federal and state laws and regulations. No Option or Restricted Stock Award shall be exercisable, no Restricted Stock Award shall be granted, no Common Stock shall be issued, no certificate for shares shall be delivered, and no payment shall be made under the Plan until the Corporation has obtained such consent or approval as the Committee may deem advisable from regulatory bodies having jurisdiction over such matters.
10.2. Participant Representations . The Committee may require that a Participant, as a condition to receipt of a particular award, execute and deliver to the Corporation a written statement, in form satisfactory to the Committee, in which the Participant represents and warrants that the shares are being acquired for such person’s own account, for investment only and not with a view to the resale or distribution thereof. The Participant shall, at the request of the Committee, be required to represent and warrant in writing that any subsequent resale or distribution of shares of Common Stock by the Participant shall be made only pursuant to either (i) a registration statement on an appropriate form under the Securities Act, which registration statement has become effective and is current with regard to the shares being sold; or (ii) a specific exemption from the registration requirements of the Securities Act, but in claiming such exemption the Participant shall, prior to any offer of sale or sale of such shares, obtain a prior favorable written opinion of counsel, in form and substance satisfactory to counsel for the Corporation, as to the application of such exemption thereto.

 

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11.  
General Provisions .
11.1. Corporation Repurchase Rights . If the Committee provides for a right of the Corporation to repurchase shares of Common Stock issued under the Plan to a Participant other than an officer, Director or Consultant, the Corporation may exercise such right as set forth in the Stock Option Agreement or Restricted Stock Agreement, provided , however , that such repurchase right shall provide (i) that the Common Stock is to be repurchased for its Fair Market Value on the date of termination of Continuous Service and the repurchase right terminates when the Common Stock becomes publicly traded; or (ii) that the repurchase is at the original purchase price for the shares of Common Stock, provided that the right to repurchase lapses at a rate of at least twenty percent (20%) of the shares per year over five (5) years from the date the right to acquire the shares was granted (without respect to the date the Option was exercised or became exercisable). In either case, the right to repurchase the shares of Common Stock may be exercised for cash or cancellation of purchase money indebtedness for the shares within ninety (90) days of the Participant’s termination of Continuous Service (or in the case of shares issued upon exercise of Options after termination of Continuous Service, within ninety (90) days after the exercise). In addition to the restrictions set forth in this Section 11.1 , the securities held by an officer, director or consultant of the Corporation or an Affiliate may be subject to additional or greater restrictions.
11.2. Information to Participants . The Corporation shall provide to each Participant and to any other individual who acquires shares of Common Stock under the Plan, not less frequently than annually during the period such Participant has an Option or Restricted Stock Award outstanding under the Plan, and, in the case of an individual who acquires Common Stock pursuant to the Plan, during the period such individual owns such Common Stock, copies of annual financial statements for the Corporation. The Corporation shall not be required to provide such statements to key employees where duties in connection with the Corporation ensure their access to equivalent information.
11.3. Effect on Employment and Service . None of the adoption of the Plan, its operation, or any documents describing or referring to the Plan (or any part thereof) shall (i) confer upon any individual any right to continue in the employ or service of the Corporation or an Affiliate; (ii) in any way affect any right and power of the Corporation or an Affiliate to change an individual’s duties or terminate the employment or service of any individual at any time with or without assigning a reason therefor; or (iii) except to the extent the Committee grants an Option or Restricted Stock Award to such individual, confer on any individual the right to participate in the benefits of the Plan.
11.4. Use of Proceeds . The proceeds received by the Corporation from the sale of Common Stock pursuant to the Plan shall be used for general corporate purposes.
11.5. Unfunded Plan . The Plan, insofar as it provides for grants, shall be unfunded, and the Corporation shall not be required to segregate any assets that may at any time be represented by grants under the Plan. Any liability of the Corporation to any person with respect to any grant under the Plan shall be based solely upon any contractual obligations that may be created pursuant to the Plan. No such obligation of the Corporation shall be deemed to be secured by any pledge of, or other encumbrance on, any property of the Corporation.
11.6. Rules of Construction . Headings are given to the Sections of the Plan solely as a convenience to facilitate reference. The reference to any statute, regulation, or other provision of law shall be construed to refer to any amendment to or successor of such provision of law.
11.7. Choice of Law . The Plan and all Stock Option Agreements and Restricted Stock Agreements entered into under the Plan shall be interpreted under the laws of the State of California, without regard to any conflict of laws.

 

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12.  
Amendment and Termination .
The Board may amend or terminate the Plan from time to time; provided, however, that shareholder approval shall be required for any amendment that (i) increases the aggregate number of shares of Common Stock that may be issued under the Plan; or (ii) changes the class of employees eligible to receive Incentive Stock Options. Except as specifically permitted by the Plan, Stock Option Agreement or Restricted Stock Agreement or as required to comply with applicable law, regulation or rule, no amendment shall, without a Participant’s consent, adversely affect any rights of such Participant under any Option or Restricted Stock Award outstanding at the time such amendment is made; provided , however , that an amendment that may cause an Incentive Stock Option to become a Nonqualified Stock Option shall not be treated as adversely affecting the rights of the Participant. Any increase in the aggregate number of shares of Common Stock available under Plan or change in class of employees eligible to receive Incentive Stock Options shall be approved by the shareholders of the Corporation within twelve (12) months of the date such amendment is adopted by the Board.
No Option or Restricted Stock Award granted pursuant to this Plan is intended to constitute “deferred compensation” as defined in Code Section 409A, and the Plan and the terms of all Options and Restricted Stock Awards shall be interpreted accordingly. If any provision of the Plan, an Option or a Restricted stock Award contravenes any regulations or Treasury guidance issued under Code Section 409A, such provision shall be modified to maintain, to the maximum extent practicable, the original intent of the applicable provision without triggering the penalties and interest under Code Section 409A.
13.  
Effective Date of Plan, Duration of Plan .
13.1. The Plan became effective as of November 17, 2006, upon adoption by the Board, subject to approval within twelve (12) months by the shareholders holding of a majority of the shares of Common Stock entitled to vote thereon. Unless and until the Plan has been approved by the shareholders of the Corporation, no Option or Restricted Stock Award may be exercised. In the event that the shareholders of the Corporation do not approve the Plan within such twelve (12) month period, the Plan and any previously granted Option or Restricted Stock Award shall terminate.
13.2. Unless previously terminated, the Plan shall terminate ten (10) years after the earlier of (i) the date the Plan is adopted by the Board; or (ii) the date the Plan is approved by the shareholders, except that Options and Restricted Stock Awards that are granted under the Plan prior to its termination shall continue to be administered under the terms of the Plan until the Options and Restricted Stock Awards terminate or are exercised.
         
  INTERNATIONAL STEM CELL CORPORATION
 
 
   By:      
    Name:      
    Title:   President  
 
   Date:      

 

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Exhibit 14.1
BTHC III, INC.
Code of Ethics for Senior Financial Officers
BTHC III, Inc. (the “Company”) is committed to conducting its business in compliance with applicable laws and regulations and in accordance with high standards of business conduct. The Company strives to maintain the highest standards of accuracy, completeness and integrity in its financial dealings, records and reports. These standards serve as the basis for managing the Company’s business, for meeting the Company’s duties to its stockholders and for maintaining compliance with financial reporting requirements. The Company’s Chief Executive Officer, principal financial officer, principal accounting officer or controller, or persons performing similar functions (collectively, the “Senior Financial Officers”) hold an important and elevated role in corporate governance. Accordingly, the Company has adopted this Code of Ethics for Senior Financial Officers (the “Code”) in compliance with Section 406 of the Sarbanes-Oxley Act of 2002.
  I.   Honest and Ethical Conduct
 
      Senior Financial Officers will exhibit and promote honest and ethical conduct by:
    Encouraging and rewarding professional integrity and eliminating barriers to responsible behavior.
 
    Promoting the ethical handling of actual or apparent conflicts of interest between personal and professional relationships.
 
    Respecting the confidentiality of information acquired in the course of work, except when authorized or otherwise legally obligated to disclose such information.
 
    Periodically communicating these ethical standards throughout the organization.
  II.   Financial Records and Periodic Reports
 
      Senior Financial Officers will establish and manage the enterprise transaction and reporting systems and procedures to provide that:
    Business transactions are properly authorized and accurately and timely recorded on the Company’s books and records in accordance with U.S. generally accepted accounting principles (“GAAP”) and policies established by the Company.

 

 


 

CODE OF ETHICS FOR SENIOR FINANCIAL OFFICERS
Page 2
    False or artificial statements are not made in the Company’s books and records, financial statements and related communications.
 
    The retention or proper disposal of Company records shall be in accordance with applicable legal and regulatory requirements and any records retention policies established by the Company.
 
    Reports and documents filed by the Company with, or submitted by the Company to, the Securities and Exchange Commission, as well as other public communications made by the Company, will include full, fair, accurate, timely and understandable disclosure.
  III.   Compliance with Applicable Laws, Rules and Regulations
 
      Senior Financial Officers will establish mechanisms to:
    Educate Company employees about applicable governmental laws, rules and regulations.
 
    Monitor compliance with applicable governmental laws, rules and regulations.
  IV.   Reporting of Non-Compliance
 
      Senior Financial Officers will promptly bring to the attention to the Audit Committee of the Company’s Board of Directors (the “Audit Committee”) or, until such time as the Audit Committee has been established, the Board of Directors:
    Material information that calls into question disclosures made by the Company in its filings with, or submissions to, the Securities and Exchange Commission or in other public communications.
 
    Information concerning significant deficiencies or material weaknesses in the design or operation of the Company’s “internal control over financial reporting” or other factors that could adversely affect the Company’s ability to record, process, summarize and report financial data.
 
    Any fraud, whether or not material, that involves management or other employees who have a significant role in the Company’s financial reporting, disclosures or internal control over financial reporting.
 
    Information concerning a violation of this Code or any other Company conduct codes, including any actual or apparent conflicts of interest between personal and professional relationships, involving management or other employees who have a significant role in the Company’s financial reporting, disclosures or internal control over financial reporting.

 

 


 

CODE OF ETHICS FOR SENIOR FINANCIAL OFFICERS
Page 3
    Evidence of a material violation by the Company or its employees or agents of applicable governmental laws, rules or regulations.
  V.   Disciplinary Action
 
      Each Senior Financial Officer is accountable for adhering to this Code. In the event of a violation by a Senior Financial Officer of this Code, the Audit Committee, or until such time as the Audit Committee has been established, the Board of Directors, shall be responsible for recommending appropriate disciplinary and/or remedial actions.

 

 

 

Exhibit 16.1
Letterhead of S. W. Hatfield, CPA
December 28, 2006
U. S. Securities and Exchange Commission
450 Fifth Street, NW
Washington, DC 20549-2001
Gentlemen:
On December 28, 2006, this Firm received a draft copy of a Current Report on Form 8-K to be filed by BTHC III, Inc. (SEC File #0-51891, CIK #1355790) (Company) reporting an Item 4.01 — Changes in Registrant’s Certifying Public Accountant.
We have no disagreements with the statements made in the draft Form 8-K, Item 4.01 disclosures which we read.
Yours truly,
/s/ S. W. Hatfield, CPA
S. W. Hatfield, CPA
Dallas, Texas

 

 

EXHIBIT 21.1
BTHC III, INC.
LISTING OF THE COMPANY’S SUBSIDIARIES
                 
                State of
    Nature of   Date Acquired       Incorporation
Name   Business   or Created   % Owned   or Formation
International Stem Cell Corporation   Biotechnology   12/28/06   100%   California
Lifeline Cell Technology, LLC   Biotechnology   12/28/06   100%*   California
 
*  
100% of the interests in Lifeline Cell Technology, LLC are owned by International Stem Cell Corporation.

 

 

Exhibit 99.1
 
Financial Statements
International Stem Cell Corporation
(A Development Stage Company)
As of September 30, 2006 and for the period from June 16, 2006 (inception) to September 30, 2006
         
 
       
REPORT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM
    2  
 
       
Balance Sheet
    3  
 
       
Statement of Operations
    4  
 
       
Statement of Stockholders’ Equity
    5  
 
       
Statement of Cash Flows
    6  
 
       
Notes to Financial Statements
    7  

 

1


 

REPORT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM
To the Board of Directors and Stockholders of
International Stem Cell Corporation
Los Angeles, California
We have audited the accompanying balance sheet of International Stem Cell Corporation (a development stage company) (the “Company”) as of September 30, 2006 and the related statements of operations, stockholders’ equity and cash flows for the initial period from inception June 16, 2006 through September 30, 2006. These financial statements are the responsibility of the Company’s management. Our responsibility is to express an opinion on these financial statements based on our audit.
We conducted our audit in accordance with the standards of the Public Company Accounting Oversight Board. Those standards require that we plan and perform the audit to obtain reasonable assurance about whether the financial statements are free of material misstatement. An audit includes examining, on a test basis, evidence supporting the amounts and disclosures in the financial statements. An audit also includes assessing the accounting principles used and significant estimates made by management, as well as evaluating the overall financial statement presentation. We believe that our audit provide a reasonable basis for our opinion.
In our opinion, the financial statements referred to above present fairly, in all material respects, the financial position of International Stem Cell Corporation as of September 30, 2006 and the results of its operations and cash flows for the initial period from inception June 16, 2006 through September 30, 2006, in conformity with accounting principles generally accepted in the United States of America.
The accompanying financial statements have been prepared assuming that the Company will continue as a going concern. As discussed in Note 1 to the financial statements, the Company expects to incur losses and needs to raise capital that raise substantial doubt about its ability to continue as a going concern. Management’s plans in regard to these matters are also described in Note 1. The financial statements do not include any adjustments that might result from the outcome of the uncertainty.
/s/ VASQUEZ & Company LLP
Los Angeles, California
December 27, 2006

 

2


 

Financial Statements
International Stem Cell Corporation
(A Development Stage Company)
Balance Sheet
         
    September 30,  
    2006  
Assets
       
Current assets
       
Due from affiliated company — Lifeline Cell Technology LLC
  $ 310,300  
Prepaid stock issue cost
    68,957  
 
     
Total assets
  $ 379,257  
 
     
Liabilities and stockholders’ equity
       
Current liabilities
       
Accrued expenses
  $ 104,862  
Due to affiliated company — Lifeline Cell Technology LLC
    55,334  
 
     
Total current liabilities
    160,196  
 
     
Total liabilities
    160,196  
 
     
Stockholders’ equity
       
Common shares $0.001 par value 50,000,000 shares authorized and unissued
     
Additional paid-in capital for stock to be issued
    310,300  
Accumulated deficit
    (91,239 )
 
     
Total stockholders’ equity
    219,061  
 
     
Total liabilities and stockholders’ equity
  $ 379,257  
 
     
See accompanying notes

 

3


 

Financial Statements
International Stem Cell Corporation
(A Development Stage Company)
Statement of Operations
From June 16, 2006 (inception) to September 30, 2006
         
    From June 16,  
    2006 to  
    September 30,  
    2006  
Expenses
       
Conferences
  $ 10,597  
Legal fees and expenses of incorporation
    11,384  
Salaries and employment
    62,500  
Other
    6,758  
 
     
Total development expenses
    91,239  
 
     
Loss before income taxes
    (91,239 )
Provision for income taxes
     
 
     
Net loss
  $ (91,239 )
 
     
See accompanying notes

 

4


 

Financial Statements
International Stem Cell Corporation
(A Development Stage Company)
Statement of Stockholders’ Equity
From June 16, 2006 (inception) to September 30, 2006
                         
    Subscriptions for     Accumulated        
    Common Stock     deficit     Total  
Activity through September 30, 2006 and balance at September 30, 2006
  $ 310,300     $ (91,239 )   $ 219,061  
 
                 
See accompanying notes

 

5


 

Financial Statements
International Stem Cell Corporation
(A Development Stage Company)
Statement of Cash Flows
From June 16, 2006 (inception) to September 30, 2006
         
    Inception  
    (June 2006)  
    through  
    September 30,  
    2006  
Operating activities
       
Net loss
  $ (91,239 )
Changes in operating assets and liabilities:
       
Accrued expenses
    104,862  
Prepaid stock issue cost
    (68,957 )
Payable to affiliated company Lifeline Cell Technology LLC
    55,334  
 
     
Net cash used in operating activities
     
 
     
Investing activities
       
Net cash used in investing activities
     
 
     
Financing activities
       
Net cash provided by financing activities
     
 
     
Net (decrease) increase in cash and cash equivalents
     
Cash and cash equivalents at beginning of period
     
 
     
Cash and cash equivalents at end of period
  $  
 
     
Supplemental disclosures of cash flow information
       
Cash received for subscriptions for common shares and owing to the Company by subsidiary company Lifeline Cell Technology, LLC
  $ 310,300  
 
     
See accompanying notes

 

6


 

International Stem Cell Corporation
(A Development Stage Company)
Notes to financial statements
1.  
Organization and Significant Accounting Policies
Organization
International Stem Cell Corporation (“International”) was formed in the State of California on June 16, 2006. International was formed for the purpose of acquiring Lifeline Cell Technology, LLC (“Lifeline”) which is in the business of developing and manufacturing human embryonic stem cells and reagents free from animal protein contamination. Lifeline’s scientists have used a technology, called basal medium optimization to systematically eliminate animal proteins from cell culture systems. Lifeline is unique in the industry in that it has in place scientific and manufacturing staff with the experience and knowledge to set up systems and facilities to produce a source of consistent, standardized, animal protein free ES cell products suitable for FDA approval.
Going Concern
The Company continues in the development stage and as such has accumulated losses from inception and expects to incur additional losses in the near future. In addition, the Company has a working capital deficiency as of September 30, 2006. To sustain operations throughout 2006 and 2007, the Company needs to obtain additional capital. Without obtaining such additional capital, there is substantial doubt about the Company’s ability to continue as a going concern. The financial statements do not include any adjustments to reflect the possible future effects on the recoverability and classification of assets or the amounts and classification of liabilities that may result from the outcome of this uncertainty.
Management’s plans in regard to these matters are focused on going public through a reverse merger with a public company.
There can be no assurance that the Company will be successful in completing any of the above noted transactions or agreements or, if completed, that such transactions or agreements will result in cash flow sufficient to sustain the Company’s operations through 2006 or 2007.
Cash Equivalents
The Company considers all highly liquid investments with a maturity of three months or less when purchased to be cash equivalents.
Short-Term Investments
Management determines the appropriate classification of marketable securities at the time of purchase, and has classified all short-term investments as available-for-sale. Such securities are stated at fair value, with the unrealized gains and losses reported as a separate component of equity. Fair value is determined based on quoted market prices.
Property and Equipment
Property and equipment are stated at cost. The provision for depreciation and amortization is computed using the straight-line method over the estimated useful lives of the assets, which generally range from three to five years. The costs of major remodeling and leasehold improvements are capitalized and depreciated over the shorter of the remaining term of the lease or the life of the asset.
Long-Lived Asset Impairment
The Company reviews long-lived assets for impairment when events or changes in business conditions indicate that their carrying value may not be recovered. The Company considers assets to be impaired and writes them down to fair value if expected associated cash flows are less than the carrying amounts. Fair value is the present value of the associated cash flows. The Company has determined that no material long-lived assets are impaired at September 30, 2006.

 

7


 

Recent Accounting Pronouncements
In October 2006, the Emerging Issues Task Force (“EITF”) issued EITF 06-3, “How Taxes Collected from Customers and Remitted to Governmental Authorities Should Be Presented in the Income Statement (That is, Gross versus Net Presentation)” to clarify diversity in practice on the presentation of different types of taxes in the financial statements. The Task Force concluded that, for taxes within the scope of the issue, a company may adopt a policy of presenting taxes either gross within revenue or net. That is, it may include charges to customers for taxes within revenues and the charge for the taxes from the taxing authority within cost of sales, or, alternatively, it may net the charge to the customer and the charge from the taxing authority. If taxes subject to EITF 06-3 are significant, a company is required to disclose its accounting policy for presenting taxes and the amounts of such taxes that are recognized on a gross basis. The guidance in this consensus is effective for the first interim reporting period beginning after December 15, 2006 (the first quarter of our fiscal year 2007). We do not expect the adoption of EITF 06-3 will have a material impact on our results of operations, financial position or cash flow.
In September 2006, the United States Securities and Exchange Commission (SEC) issued Staff Accounting Bulletin No. 108, “Considering the Effects of Prior Year Misstatements when Quantifying Misstatements in Current Year Financial Statements” (“SAB 108”). This SAB provides guidance on the consideration of the effects of prior year misstatements in quantifying current year misstatements for the purpose of a materiality assessment. SAB 108 establishes an approach that requires quantification of financial statement errors based on the effects on each of the company’s balance sheets, statements of operations and related financial statement disclosures. The SAB permits existing public companies to record the cumulative effect of initially applying this approach in the first year ending after November 15, 2006 by recording the necessary correcting adjustments to the carrying values of assets and liabilities as of the beginning of that year with the offsetting adjustment recorded to the opening balance of retained earnings. Additionally, the use of the cumulative effect transition method requires detailed disclosure of the nature and amount of each individual error being corrected through the cumulative adjustment and how and when it arose. The Company is currently evaluating the impact SAB 108 may have on its results of operations and financial condition.
In September 2006, the FASB issued SFAS No. 158, “Employer’s accounting for Defined Benefit Pension and Other Post Retirement Plans”. SFAS No. 158 requires employers to recognize in its statement of financial position an asset or liability based on the retirement plan’s over or under funded status. SFAS No. 158 is effective for fiscal years ending after December 15, 2006. The Company is currently evaluating the effect that the application of SFAS No. 158 will have on its results of operations and financial condition.
In September 2006, the Financial Accounting Standards Board (FASB) issued Statement of Financial Accounting Issues No. 157, “Fair Value Measurements” (“SFAS 157”), which defines the fair value, establishes a framework for measuring fair value and expands disclosures about fair value measurements. This statement is effective for financial statements issued for fiscal years beginning after November 15, 2007, and interim periods within those fiscal years. Early adoption is encouraged, provided that the Company has not yet issued financial statements for that fiscal year, including any financial statements for an interim period within that fiscal year. The Company is currently evaluating the impact SFAS 157 may have on its financial condition or results of operations.
In July 2006, the FASB released FASB Interpretation No. 48, Accounting for Uncertainty in Income Taxes, an interpretation of FASB Statement No. 109 (FIN 48). FIN 48 clarifies the accounting and reporting for uncertainties in income tax law. This interpretation prescribes a comprehensive model for the financial statement recognition, measurement, presentation and disclosure of uncertain tax positions taken or expected to be taken in income tax returns. This statement is effective for fiscal years beginning after December 15, 2006. The Company is currently evaluating the impact FIN 48 may have on its financial condition or results of operations.

 

8


 

In March 2006, the FASB issued SFAS No. 156, “Accounting for Servicing of Financial Assets” (“SFAS NO. 156”), which provides an approach to simplify efforts to obtain hedge-like (offset) accounting. This Statement amends FASB Statement No. 140, “Accounting for Transfers and Servicing of Financial Assets and Extinguishments of Liabilities”, with respect to the accounting for separately recognized servicing assets and servicing liabilities. The Statement (1) requires an entity to recognize a servicing asset or servicing liability each time it undertakes an obligation to service a financial asset by entering into a servicing contract in certain situations; (2) requires that a separately recognized servicing asset or servicing liability be initially measured at fair value, if practicable; (3) permits an entity to choose either the amortization method or the fair value method for subsequent measurement for each class of separately recognized servicing assets or servicing liabilities; (4) permits at initial adoption a one-time reclassification of available-for-sale securities to trading securities by an entity with recognized servicing rights, provided the securities reclassified offset the entity’s exposure to changes in the fair value of the servicing assets or liabilities; and (5) requires separate presentation of servicing assets and servicing liabilities subsequently measured at fair value in the balance sheet and additional disclosures for all separately recognized servicing assets and servicing liabilities. SFAS No. 156 is effective for all separately recognized servicing assets and liabilities as of the beginning of an entity’s fiscal year that begins after September 15, 2006, with earlier adoption permitted in certain circumstances. The Statement also describes the manner in which it should be initially applied. The Company does not believe that SFAS No. 156 will have a material impact on its financial position, results of operations or cash flows.
In February 2006, the FASB issued SFAS No. 155, “Accounting for Certain Hybrid Financial Instruments”, which amends SFAS No. 133, “Accounting for Derivatives Instruments and Hedging Activities” and SFAS No. 140, “Accounting for Transfers and Servicing of Financial Assets and Extinguishment of Liabilities”. SFAS No. 155 amends SFAS No. 133 to narrow the scope exception for interest-only and principal-only strips on debt instruments to include only such strips representing rights to receive a specified portion of the contractual interest or principle cash flows. SFAS No. 155 also amends SFAS No. 140 to allow qualifying special-purpose entities to hold a passive derivative financial instrument pertaining to beneficial interests that itself is a derivative instrument. The Company is currently evaluating this new Standard but cannot determine the future impact as the Company does not have any “Derivatives Instruments and Hedging Activities”, but may implement them in the future.
In November 2005, the FASB issued FSP FAS 115-1 and FAS 124-1, “The Meaning of Other-Than-Temporary Impairment and Its Application to Certain Investments” (“FSP 115-1 and 124-1”), which clarifies when an investment is considered impaired, whether the impairment is other-than-temporary, and the measurement of an impairment loss. It also includes accounting considerations subsequent to the recognition of the other-than-temporary impairment and requires certain disclosures about unrealized losses that have not been recognized as other-than-temporary impairments. FSP 115-1 and 124-1 are effective for all reporting periods beginning after December 15, 2005. The Company does not anticipate that the implementation of these statements will have a significant impact on its financial position, results of operations or cash flows.
In May 2005, the FASB issued SFAS No. 154, “Accounting Changes and Error Corrections” (“SFAS No. 154”). SFAS No. 154 is a replacement of Accounting Principles Board Opinion No. 20 and SFAS No. 3. SFAS No. 154 provides guidance on the accounting for and reporting of accounting changes and error corrections. It establishes retrospective application as the required method for reporting a change in accounting principle. SFAS No. 154 provides guidance for determining whether retrospective application of a change in accounting principle is impracticable and for reporting a change when retrospective application is impracticable. SFAS No. 154 also addresses the reporting of a correction of an error by restating previously issued financial statements. SFAS No 154 is effective for accounting changes and corrections of errors made in fiscal years beginning after December 15, 2005. The Company does not believe that it will have a material impact on its financial position, results of operations or cash flows.

 

9


 

In December 2004, the Financial Accounting Standards Board (“FASB”) issued SFAS No. 153, “Exchanges of Nonmonetary Assets, an amendment of APB Opinion No. 29, Accounting for Nonmonetary Transactions.” The amendments made by Statement 153 are based on the principle that exchanges of nonmonetary assets should be measured based on the fair value of the assets exchanged. Further, the amendments eliminate the narrow exception for nonmonetary exchanges of similar productive assets and replace it with a broader exception for exchanges of nonmonetary assets that do not have commercial substance. Previously, Opinion 29 required that the accounting for an exchange of a productive asset for a similar productive asset or an equivalent interest in the same or similar productive asset should be based on the recorded amount of the asset relinquished. Opinion 29 provided an exception to its basic measurement principle (fair value) for exchanges of similar productive assets. The FASB believes that exception required that some nonmonetary exchanges, although commercially substantive, be recorded on a carryover basis. By focusing the exception on exchanges that lack commercial substance, the FASB believes this statement produces financial reporting that more faithfully represents the economics of the transactions. SFAS 153 is effective for nonmonetary asset exchanges occurring in fiscal periods beginning after June 15, 2005. Earlier application is permitted for nonmonetary asset exchanges occurring in fiscal periods beginning after the date of issuance. The provisions of SFAS 153 shall be applied prospectively. The Company has evaluated the impact of the adoption of SFAS 153, and does not believe the impact will be significant to the Company’s overall results of operations or financial position.
In December 2004, the FASB issued SFAS No. 123 (revised 2004), “Share-Based Payment”. SFAS 123(R) will provide investors and other users of financial statements with more complete and neutral financial information by requiring that the compensation cost relating to share-based payment transactions be recognized in financial statements. That cost will be measured based on the fair value of the equity or liability instruments issued. SFAS 123(R) covers a wide range of share-based compensation arrangements including share options, restricted share plans, performance-based awards, share appreciation rights, and employee share purchase plans. SFAS 123(R) replaces FASB Statement No. 123, “Accounting for Stock-Based Compensation”, and supersedes APB Opinion No. 25, “Accounting for Stock Issued to Employees”. SFAS 123, as originally issued in 1995, established as preferable a fair-value-based method of accounting for share-based payment transactions with employees. However, that statement permitted entities the option of continuing to apply the guidance in Opinion 25, as long as the footnotes to financial statements disclosed what net income would have been had the preferable fair-value-based method been used. Public entities (other than those filing as small business issuers) will be required to apply SFAS 123(R) as of the first interim or annual reporting period that begins after June 15, 2005. SFAS 123(R) is applicable for ASC effective the first interim period that starts after July 1, 2005. The Company has evaluated the impact of the adoption of SFAS 123(R), and cannot determine the future impact as the Company does not have any “Share Based Payment” compensations programs, but may implement them in the future.
In November 2004, the FASB issued SFAS No. 151, “Inventory Costs, an amendment of ARB No. 43, Chapter 4”. The amendments made by Statement 151 clarify that abnormal amounts of idle facility expense, freight, handling costs, and wasted materials (spoilage) should be recognized as current period charges and require the allocation of fixed production overheads to inventory based on the normal capacity of the production facilities. The guidance is effective for inventory costs incurred during fiscal years beginning after June 15, 2005. Earlier application is permitted for inventory costs incurred during fiscal years beginning after November 23, 2004. The Company has evaluated the impact of the adoption of SFAS 151, and does not believe the impact will be significant to the Company’s overall results of operations or financial position since the Company does not currently have any manufacturing operations or inventory.
In March 2004, the FASB approved the consensus reached on the Emerging Issues Task Force (EITF) Issue No. 03-1, “The Meaning of Other-Than-Temporary Impairment and Its Application to Certain Investments.” The objective of this Issue is to provide guidance for identifying impaired investments. EITF 03-1 also provides new disclosure requirements for investments that are deemed to be temporarily impaired. The accounting provisions of EITF 03-1 are effective for all reporting periods beginning after June 15, 2004, while the disclosure requirements for certain investments are effective for annual periods ending after December 15, 2003, and for other investments such disclosure requirements are effective for annual periods ending after June 15, 2004.

 

10


 

In December 2003, the SEC issued Staff Accounting Bulletin (“SAB”) No. 104 (“SAB No. 104”), “Revenue Recognition.” SAB No. 104 supersedes SAB No. 101, “Revenue Recognition in Financial Statements.” SAB No. 104, which was effective upon issuance, rescinded certain guidance contained in SAB No. 101 related to multiple element revenue arrangements, and replaced such guidance with that contained in EITF 00-21, “Accounting for Revenue Arrangements with Multiple Deliverables.” Additionally, SAB No. 104 rescinded the SEC’s Revenue Recognition in Financial Statements Frequently Asked Questions and Answers issued with SAB No. 101. The revenue recognition principles of SAB No. 101 remain largely unchanged by the issuance of SAB No. 104, and therefore the adoption of SAB No. 104 did not have a material effect on the Company’s results of operations or financial condition.
In January 2003, the FASB issued FASB Interpretation No. (“FIN”) 46, “Consolidation of Variable Interest Entities” (“FIN 46”). In December 2003, FIN 46 was replaced by FASB interpretation No. 46(R) “Consolidation of Variable Interest Entities.” FIN 46(R) clarifies the application of Accounting Research Bulletin No. 51, “Consolidated Financial Statements,” to certain entities in which equity investors do not have the characteristics of a controlling financial interest or do not have sufficient equity at risk for the entity to finance its activities without additional subordinated financial support from other parties. FIN 46(R) requires an enterprise to consolidate a variable interest entity if that enterprise will absorb a majority of the entity’s expected losses, is entitled to receive a majority of the entity’s expected residual returns, or both. FIN 46(R) is effective for entities being evaluated under FIN 46(R) for consolidation no later than the end of the first reporting period that ends after March 15, 2004. The Company does not currently have any variable interest entities that will be impacted by adoption of FIN 46(R).
Income Taxes
Income taxes are recorded in accordance with SFAS No. 109, Accounting for Income Taxes , which requires the use of the liability method for deferred income taxes. No deferred tax benefit for the current period net operating loss has been recognized in the financial statements due to the uncertainty as to its realizability in future periods.
Use of Estimates
The preparation of the financial statements in conformity with accounting principles generally accepted in the United States requires management to make estimates and assumptions that affect the reported amounts of assets and liabilities and disclosure of contingent assets and liabilities at the date of the financial statements. Significant estimates relate primarily to accrued expenses. Actual results could differ from those estimates.
2.  
Due from Affiliated Company Lifeline Cell Technology, LLC
Subscriptions for 344,778 shares of common stock in the amount of $310,000 have been received. Because the Company had not yet opened a bank account, the cash was deposited in the account of Lifeline Cell Technology, LLC, an associated company (see Note 4 Subsequent Events) for the account of the Company.
3.  
Due to Affiliated Company Lifeline Cell Technology, LLC
Payments for operating expenses have been made by Lifeline Cell Technology, LLC, an associated company (see Note 4 Subsequent Events) for the account of the Company.
4.  
Subsequent Events
On November 7, 2006 International entered into a Share Exchange Agreement (the “ISC Agreement”) between Lifeline Cell Technology LLC (“Lifeline”), International and the holders of membership units and warrants for the purchase of membership interests of Lifeline. Pursuant to the terms of the Agreement all the membership units in Lifeline were exchanged for 20,000,000 shares of International $0.001 par value Common Stock and for International’s assumption of Lifeline’s obligations under the warrants. Lifeline became a wholly-owned subsidiary of International.

 

11


 

On November 7, 2006 the Company issued 580,000 qualified and 2,507,500 non-qualified stock options to purchase shares of International $0.001 value Common Stock to Executives (1,750,000 options), employees (490,000), and consultants (847,500) of the Company. The options vest over varying periods from zero to three years and expire at the end of ten years. Each option permits the holder to purchase one share of common stock of the Company for $1.00 . If the recipient ceases to provide services to the Company or its affiliates, only those options vested may be exercised. The Company will calculate the grant date fair value of employee stock options using the straight line method as the options vest. For non-employees, the Company will use EITF 96-18, Accounting for Equity Instruments That Are Issued to Other Than Employees for Acquiring, or in Conjunction with Selling, Goods or Services.
In November and December 2006 International received subscriptions for 11,205,950 shares of its common stock in the amount of $9,630,651, net of fees and commissions, raised under a private placement memorandum. In addition to the subscriptions raised under the private placement memorandum, the Company received subscriptions for 344,778 shares of its common stock in the amount of $310,300 prior to September 30, 2006 and an additional 210,774 shares of its common stock in the amount of $189,700 in November and December 2006.

 

12

 

Exhibit 99.2
 
Financial Statements
Lifeline Cell Technology, LLC
(A Development Stage Company)
Years ended December 31, 2004 and 2005
         
 
       
REPORT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM
    2  
 
       
Balance Sheets
    3  
 
       
Statements of Operations
    4  
 
       
Statements of Members’ Equity
    5  
 
       
Statements of Cash Flows
    6  
 
       
Notes to Financial Statements
    7  

 

1


 

REPORT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM
To the Board of Directors and Stockholders of
Lifeline Cell Technology, LLC
(A Development Stage Company)
Los Angeles, California
We have audited the accompanying balance sheets of Lifeline Cell Technology, LLC (a development stage company) (the “Company”) as of December 31, 2005 and 2004, and the related statements of operations, members’ equity and cash flows for each of the two years ended December 31. These financial statements are the responsibility of the Company’s management. Our responsibility is to express an opinion on these financial statements based on our audits.
We conducted our audits in accordance with the standards of the Public Company Accounting Oversight Board (United States). Those standards require that we plan and perform the audit to obtain reasonable assurance about whether the financial statements are free of material misstatement. The Company is not required to have, nor were we engaged to perform, an audit of its internal control over financial reporting. Our audit included consideration of internal control over financial reporting as a basis for designing audit procedures that are appropriate in the circumstances, but not for the purpose of expressing an opinion on the effectiveness of the Company’s internal control over financial reporting. Accordingly, we express no such opinion. An audit includes examining, on a test basis, evidence supporting the amounts and disclosures in the financial statements. An audit also includes assessing the accounting principles used and significant estimates made by management, as well as evaluating the overall financial statement presentation. We believe that our audits provide a reasonable basis for our opinion.
In our opinion, the financial statements referred to above present fairly, in all material respects, the financial position of Lifeline Cell Technology, LLC as of December 31, 2005 and 2004, and the results of its operations and its cash flows for each of the years in the two-year period ended December 31, 2005, in conformity with accounting principles generally accepted in the United States of America.
The accompanying financial statements have been prepared assuming that the Company will continue as a going concern. As discussed in Note 1 to the financial statements, the Company expects to incur losses and needs to raise capital, which raise substantial doubt about its ability to continue as a going concern. Management’s plans in regard to these matters are also described in Note 1. The financial statements do not include any adjustments that might result from the outcome of the uncertainty.
/s/ VASQUEZ & Company LLP
Los Angeles, California
December 27, 2006

 

2


 

Financial Statements
Lifeline Cell Technology, LLC
(A Development Stage Company)
Balance Sheets
                 
    December 31,  
    2005     2004  
Assets
               
Current assets
               
Cash and cash equivalents
  $ 33,305     $ 9,736  
Other current assets
    218        
 
           
Total current assets
    33,523       9,736  
Property and equipment, net
    101,586       66,219  
Patent licenses, net
    717,142       746,696  
Deposits and other assets
    2,025       2,025  
 
           
Total assets
  $ 854,276     $ 824,676  
 
           
Liabilities and members’ equity
               
Current liabilities
               
Accounts payable
  $ 43,823     $ 4,432  
Accrued expenses
    45,393       56,307  
Promissory note
    600,000        
Related party payables
    673,797       699,855  
 
           
Total current liabilities
    1,363,013       760,594  
Promissory notes
    347,368       314,442  
 
           
Total liabilities
    1,710,381       1,075,036  
 
           
Members’ equity
               
Members’ contribution
    2,435,000       1,655,000  
Accumulated deficit
    (3,291,105 )     (1,905,360 )
 
           
Total members’ equity
    (856,105 )     (250,360 )
 
           
Total liabilities and members’ equity
  $ 854,276     $ 824,676  
 
           
See accompanying notes

 

3


 

Financial Statements
Lifeline Cell Technology, LLC
(A Development Stage Company)
Statements of Operations
                         
                    Inception  
                    (August 2001)  
                    through  
    Year Ended December 31,     December 31,  
    2005     2004     2005  
Sales
  $ 158             $ 158  
Cost of sales
    47               47  
 
                   
Gross profit
    111               111  
Development expenses
                       
Research and development
    804,191     $ 585,494       1,997,323  
Marketing
    36,361       2,163       38,524  
General and administrative
    461,634       197,579       1,045,377  
 
                 
Total development expenses
    1,302,186       785,236       3,081,224  
 
                 
Loss from development activities
    (1,302,075 )     (785,236 )     (3,081,113 )
Other income (expense)
                       
Miscellaneous income
    5,045             5,045  
Interest income
    405       39       444  
Interest expense
    (96,120 )     (69,608 )     (220,168 )
Sublease income
    7,800       887       8,687  
 
                 
Total other expense
    (82,870 )     (68,682 )     (205,992 )
 
                 
Loss before income taxes
    (1,384,945 )     (853,918 )     (3,287,105 )
Provision for income taxes
    800       800       4,000  
 
                 
Net loss
  ($ 1,385,745 )   ($ 854,718 )   ($ 3,291,105 )
 
                 
See accompanying notes

 

4


 

Financial Statements
Lifeline Cell Technology, LLC
(A Development Stage Company)
Statements of Members’ Equity
                         
    Members     Accumulated        
    contributions     deficit     Total  
Activity through December 31, 2001
  $ 100,000     ($ 140,996 )   ($ 40,996 )
Members contributions
    250,000             250,000  
Net loss
          (390,751 )     (390,751 )
 
                 
Balance at December 31, 2002
    350,000       (531,747 )     (181,747 )
Members contributions
    195,000             195,000  
Net loss
          (518,895 )     (518,895 )
 
                 
Balance at December 31, 2003
    545,000       (1,050,642 )     (505,642 )
Members contributions
    1,110,000             1,110,000  
Net loss
          (854,718 )     (854,718 )
 
                 
Balance at December 31, 2004
    1,655,000       (1,905,360 )     (250,360 )
Members contributions
    780,000             780,000  
Net loss
          (1,385,745 )     (1,385,745 )
 
                 
Balance at December 31, 2005
  $ 2,435,000     ($ 3,291,105 )   ($ 856,105 )
 
                 
See accompanying notes

 

5


 

Lifeline Cell Technology, LLC
(A Development Stage Company)
Statements of Cash Flows
                         
                    Inception  
                    (August 2001)  
                    through  
    Year ended December 31,     December 31,  
    2005     2004     2005  
Net loss
  ($ 1,385,745 )   ($ 854,718 )   ($ 3,291,105 )
Adjustments to reconcile net loss to net cash used in operating activities:
                       
Depreciation and amortization
    87,642       16,242       110,224  
Changes in operating assets and liabilities:
                       
Increase in accounts receivable
    (218 )           (218 )
Increase in deposits
          (2,025 )     (2,025 )
Increase in accounts payable
    39,391       4,432       43,823  
Increase (decrease) in accrued expenses
    (10,915 )     48,622       45,392  
Increase (decrease) in related party payables
    (26,057 )     85,148       673,798  
 
                 
Net cash used in operating activities
    (1,295,902 )     (702,299 )     (2,420,111 )
 
                 
Investing activities
                       
Purchases of property and equipment
    (56,899 )     (81,476 )     (145,700 )
Payments for patent licenses
    (3,630 )     (746,696 )     (750,326 )
 
                 
Net cash used in investing activities
    (60,529 )     (828,172 )     (896,026 )
 
                 
Financing activities
                       
Proceeds from members’ contributions
    780,000       1,110,000       2,435,000  
Issuance of convertible notes payable
    600,000       400,000       914,442  
 
                 
Net cash provided by financing activities
    1,380,000       1,510,000       3,349,442  
 
                 
Net (decrease) increase in cash and cash equivalents
    23,569       (20,471 )     33,305  
Cash and cash equivalents at beginning of period
    9,736       30,207        
 
                 
Cash and cash equivalents at end of period
  $ 33,305     $ 9,736     $ 33,305  
 
                 
Supplemental disclosures of cash flow information
                       
Cash paid for income taxes
  $ 800     $ 800     $ 4,000  
 
                 
See accompanying notes

 

6


 

Lifeline Cell Technology, LLC
(A Development Stage Company)
Notes to financial statements
1.  
Organization and Significant Accounting Policies
Organization
Lifeline Cell Technology, LLC (“Lifeline”) was formed in the State of California on August 17, 2001. Lifeline is in the business of developing and manufacturing human embryonic stem cells and reagents free from animal protein contamination. Lifeline’s scientists have used a technology, called basal medium optimization to systematically eliminate animal proteins from cell culture systems. Lifeline is unique in the industry in that it has in place scientific and manufacturing staff with the experience and knowledge to set up systems and facilities to produce a source of consistent, standardized, animal protein free ES cell products suitable for FDA approval.
Going Concern
Lifeline continues in the development stage and as such has accumulated losses from inception and expects to incur additional losses in the near future. In addition, Lifeline has a working capital deficiency as of December 31, 2005. To sustain operations throughout 2006 and 2007, Lifeline needs to obtain additional capital. Without obtaining such additional capital, there is substantial doubt about Lifeline’s ability to continue as a going concern. The financial statements do not include any adjustments to reflect the possible future effects on the recoverability and classification of assets or the amounts and classification of liabilities that may result from the outcome of this uncertainty.
Management’s plans in regard to these matters are focused on currently raising $1,200,000 in the form of notes and, in the near future, either going public or arranging substantial financing with a substantial investor.
There can be no assurance that Lifeline will be successful in completing any of the above noted transactions or agreements or, if completed, that such transactions or agreements will result in cash flow sufficient to sustain Lifeline’s operations through 2006 or 2007.
Cash Equivalents
Lifeline considers all highly liquid investments with a maturity of three months or less when purchased to be cash equivalents.
Short-Term Investments
Management determines the appropriate classification of marketable securities at the time of purchase, and has classified all short-term investments as available-for-sale. Such securities are stated at fair value, with the unrealized gains and losses reported as a separate component of equity. Fair value is determined based on quoted market prices.
Property and Equipment
Property and equipment are stated at cost. The provision for depreciation and amortization is computed using the straight-line method over the estimated useful lives of the assets, which generally range from three to five years. The costs of major remodeling and leasehold improvements are capitalized and depreciated over the shorter of the remaining term of the lease or the life of the asset.
Long-Lived Asset Impairment
Lifeline reviews long-lived assets for impairment when events or changes in business conditions indicate that their carrying value may not be recovered. Lifeline considers assets to be impaired and writes them down to fair value if expected associated cash flows are less than the carrying amounts. Fair value is the present value of the associated cash flows. Lifeline has determined that no material long-lived assets are impaired at December 31, 2005.

 

7


 

Recent Accounting Pronouncements
In October 2006, the Emerging Issues Task Force (“EITF”) issued EITF 06-3, “How Taxes Collected from Customers and Remitted to Governmental Authorities Should Be Presented in the Income Statement (That is, Gross versus Net Presentation)” to clarify diversity in practice on the presentation of different types of taxes in the financial statements. The Task Force concluded that, for taxes within the scope of the issue, a company may adopt a policy of presenting taxes either gross within revenue or net. That is, it may include charges to customers for taxes within revenues and the charge for the taxes from the taxing authority within cost of sales, or, alternatively, it may net the charge to the customer and the charge from the taxing authority. If taxes subject to EITF 06-3 are significant, a company is required to disclose its accounting policy for presenting taxes and the amounts of such taxes that are recognized on a gross basis. The guidance in this consensus is effective for the first interim reporting period beginning after December 15, 2006 (the first quarter of our fiscal year 2007). We do not expect the adoption of EITF 06-3 will have a material impact on our results of operations, financial position or cash flow.
In September 2006, the United States Securities and Exchange Commission (SEC) issued Staff Accounting Bulletin No. 108, “Considering the Effects of Prior Year Misstatements when Quantifying Misstatements in Current Year Financial Statements” (“SAB 108”). This SAB provides guidance on the consideration of the effects of prior year misstatements in quantifying current year misstatements for the purpose of a materiality assessment. SAB 108 establishes an approach that requires quantification of financial statement errors based on the effects on each of the company’s balance sheets, statements of operations and related financial statement disclosures. The SAB permits existing public companies to record the cumulative effect of initially applying this approach in the first year ending after November 15, 2006 by recording the necessary correcting adjustments to the carrying values of assets and liabilities as of the beginning of that year with the offsetting adjustment recorded to the opening balance of retained earnings. Additionally, the use of the cumulative effect transition method requires detailed disclosure of the nature and amount of each individual error being corrected through the cumulative adjustment and how and when it arose. The Company is currently evaluating the impact SAB 108 may have on its results of operations and financial condition.
In September 2006, the FASB issued SFAS No. 158, “Employer’s accounting for Defined Benefit Pension and Other Post Retirement Plans”. SFAS No. 158 requires employers to recognize in its statement of financial position an asset or liability based on the retirement plan’s over or under funded status. SFAS No. 158 is effective for fiscal years ending after December 15, 2006. The Company is currently evaluating the effect that the application of SFAS No. 158 will have on its results of operations and financial condition.
In September 2006, the Financial Accounting Standards Board (FASB) issued Statement of Financial Accounting Issues No. 157, “Fair Value Measurements” (“SFAS 157”), which defines the fair value, establishes a framework for measuring fair value and expands disclosures about fair value measurements. This statement is effective for financial statements issued for fiscal years beginning after November 15, 2007, and interim periods within those fiscal years. Early adoption is encouraged, provided that the Company has not yet issued financial statements for that fiscal year, including any financial statements for an interim period within that fiscal year. The Company is currently evaluating the impact SFAS 157 may have on its financial condition or results of operations.
In July 2006, the FASB released FASB Interpretation No. 48, Accounting for Uncertainty in Income Taxes, an interpretation of FASB Statement No. 109 (FIN 48). FIN 48 clarifies the accounting and reporting for uncertainties in income tax law. This interpretation prescribes a comprehensive model for the financial statement recognition, measurement, presentation and disclosure of uncertain tax positions taken or expected to be taken in income tax returns. This statement is effective for fiscal years beginning after December 15, 2006. The Company is currently evaluating the impact FIN 48 may have on its financial condition or results of operations.

 

8


 

In March 2006, the FASB issued SFAS No. 156, “Accounting for Servicing of Financial Assets” (“SFAS NO. 156”), which provides an approach to simplify efforts to obtain hedge-like (offset) accounting. This Statement amends FASB Statement No. 140, “Accounting for Transfers and Servicing of Financial Assets and Extinguishments of Liabilities”, with respect to the accounting for separately recognized servicing assets and servicing liabilities. The Statement (1) requires an entity to recognize a servicing asset or servicing liability each time it undertakes an obligation to service a financial asset by entering into a servicing contract in certain situations; (2) requires that a separately recognized servicing asset or servicing liability be initially measured at fair value, if practicable; (3) permits an entity to choose either the amortization method or the fair value method for subsequent measurement for each class of separately recognized servicing assets or servicing liabilities; (4) permits at initial adoption a one-time reclassification of available-for-sale securities to trading securities by an entity with recognized servicing rights, provided the securities reclassified offset the entity’s exposure to changes in the fair value of the servicing assets or liabilities; and (5) requires separate presentation of servicing assets and servicing liabilities subsequently measured at fair value in the balance sheet and additional disclosures for all separately recognized servicing assets and servicing liabilities. SFAS No. 156 is effective for all separately recognized servicing assets and liabilities as of the beginning of an entity’s fiscal year that begins after September 15, 2006, with earlier adoption permitted in certain circumstances. The Statement also describes the manner in which it should be initially applied. The Company does not believe that SFAS No. 156 will have a material impact on its financial position, results of operations or cash flows.
In February 2006, the FASB issued SFAS No. 155, “Accounting for Certain Hybrid Financial Instruments”, which amends SFAS No. 133, “Accounting for Derivatives Instruments and Hedging Activities” and SFAS No. 140, “Accounting for Transfers and Servicing of Financial Assets and Extinguishment of Liabilities”. SFAS No. 155 amends SFAS No. 133 to narrow the scope exception for interest-only and principal-only strips on debt instruments to include only such strips representing rights to receive a specified portion of the contractual interest or principle cash flows. SFAS No. 155 also amends SFAS No. 140 to allow qualifying special-purpose entities to hold a passive derivative financial instrument pertaining to beneficial interests that itself is a derivative instrument. The Company is currently evaluating this new Standard but cannot determine the future impact as the Company does not have any “Derivatives Instruments and Hedging Activities”, but may implement them in the future.
In November 2005, the FASB issued FSP FAS 115-1 and FAS 124-1, “The Meaning of Other-Than-Temporary Impairment and Its Application to Certain Investments” (“FSP 115-1 and 124-1”), which clarifies when an investment is considered impaired, whether the impairment is other-than-temporary, and the measurement of an impairment loss. It also includes accounting considerations subsequent to the recognition of the other-than-temporary impairment and requires certain disclosures about unrealized losses that have not been recognized as other-than-temporary impairments. FSP 115-1 and 124-1 are effective for all reporting periods beginning after December 15, 2005. The Company does not anticipate that the implementation of these statements will have a significant impact on its financial position, results of operations or cash flows.
In May 2005, the FASB issued SFAS No. 154, “Accounting Changes and Error Corrections” (“SFAS No. 154”). SFAS No. 154 is a replacement of Accounting Principles Board Opinion No. 20 and SFAS No. 3. SFAS No. 154 provides guidance on the accounting for and reporting of accounting changes and error corrections. It establishes retrospective application as the required method for reporting a change in accounting principle. SFAS No. 154 provides guidance for determining whether retrospective application of a change in accounting principle is impracticable and for reporting a change when retrospective application is impracticable. SFAS No. 154 also addresses the reporting of a correction of an error by restating previously issued financial statements. SFAS No 154 is effective for accounting changes and corrections of errors made in fiscal years beginning after December 15, 2005. The Company does not believe that it will have a material impact on its financial position, results of operations or cash flows.
In December 2004, the Financial Accounting Standards Board (“FASB”) issued SFAS No. 153, “Exchanges of Nonmonetary Assets, an amendment of APB Opinion No. 29, Accounting for Nonmonetary Transactions.” The amendments made by Statement 153 are based on the principle that exchanges of nonmonetary assets should be measured based on the fair value of the assets exchanged. Further, the amendments eliminate the narrow exception for nonmonetary exchanges of similar productive assets and replace it with a broader exception for exchanges of nonmonetary assets that do not have commercial substance. Previously, Opinion 29 required that the accounting for an exchange of a productive asset for a similar productive asset or an equivalent interest in the same or similar productive asset should be based on the recorded amount of the asset relinquished. Opinion 29 provided an exception to its basic measurement principle (fair value) for exchanges of similar productive assets. The FASB believes that exception required that some nonmonetary exchanges, although commercially substantive, be recorded on a carryover basis. By focusing the exception on exchanges that lack commercial substance, the FASB believes this statement produces financial reporting that more faithfully represents the economics of the transactions. SFAS 153 is effective for nonmonetary asset exchanges occurring in fiscal periods beginning after June 15, 2005. Earlier application is permitted for nonmonetary asset exchanges occurring in fiscal periods beginning after the date of issuance. The provisions of SFAS 153 shall be applied prospectively. The Company has evaluated the impact of the adoption of SFAS 153, and does not believe the impact will be significant to the Company’s overall results of operations or financial position.

 

9


 

In December 2004, the FASB issued SFAS No. 123 (revised 2004), “Share-Based Payment”. SFAS 123(R) will provide investors and other users of financial statements with more complete and neutral financial information by requiring that the compensation cost relating to share-based payment transactions be recognized in financial statements. That cost will be measured based on the fair value of the equity or liability instruments issued. SFAS 123(R) covers a wide range of share-based compensation arrangements including share options, restricted share plans, performance-based awards, share appreciation rights, and employee share purchase plans. SFAS 123(R) replaces FASB Statement No. 123, “Accounting for Stock-Based Compensation”, and supersedes APB Opinion No. 25, “Accounting for Stock Issued to Employees”. SFAS 123, as originally issued in 1995, established as preferable a fair-value-based method of accounting for share-based payment transactions with employees. However, that statement permitted entities the option of continuing to apply the guidance in Opinion 25, as long as the footnotes to financial statements disclosed what net income would have been had the preferable fair-value-based method been used. Public entities (other than those filing as small business issuers) will be required to apply SFAS 123(R) as of the first interim or annual reporting period that begins after June 15, 2005. SFAS 123(R) is applicable for ASC effective the first interim period that starts after July 1, 2005. The Company has evaluated the impact of the adoption of SFAS 123(R), and cannot determine the future impact as the Company does not have any “Share Based Payment” compensations programs, but may implement them in the future.
In November 2004, the FASB issued SFAS No. 151, “Inventory Costs, an amendment of ARB No. 43, Chapter 4”. The amendments made by Statement 151 clarify that abnormal amounts of idle facility expense, freight, handling costs, and wasted materials (spoilage) should be recognized as current period charges and require the allocation of fixed production overheads to inventory based on the normal capacity of the production facilities. The guidance is effective for inventory costs incurred during fiscal years beginning after June 15, 2005. Earlier application is permitted for inventory costs incurred during fiscal years beginning after November 23, 2004. The Company has evaluated the impact of the adoption of SFAS 151, and does not believe the impact will be significant to the Company’s overall results of operations or financial position since the Company does not currently have any manufacturing operations or inventory.
In March 2004, the FASB approved the consensus reached on the Emerging Issues Task Force (EITF) Issue No. 03-1, “The Meaning of Other-Than-Temporary Impairment and Its Application to Certain Investments.” The objective of this Issue is to provide guidance for identifying impaired investments. EITF 03-1 also provides new disclosure requirements for investments that are deemed to be temporarily impaired. The accounting provisions of EITF 03-1 are effective for all reporting periods beginning after June 15, 2004, while the disclosure requirements for certain investments are effective for annual periods ending after December 15, 2003, and for other investments such disclosure requirements are effective for annual periods ending after June 15, 2004.
In December 2003, the SEC issued Staff Accounting Bulletin (“SAB”) No. 104 (“SAB No. 104”), “Revenue Recognition.” SAB No. 104 supersedes SAB No. 101, “Revenue Recognition in Financial Statements.” SAB No. 104, which was effective upon issuance, rescinded certain guidance contained in SAB No. 101 related to multiple element revenue arrangements, and replaced such guidance with that contained in EITF 00-21, “Accounting for Revenue Arrangements with Multiple Deliverables.” Additionally, SAB No. 104 rescinded the SEC’s Revenue Recognition in Financial Statements Frequently Asked Questions and Answers issued with SAB No. 101. The revenue recognition principles of SAB No. 101 remain largely unchanged by the issuance of SAB No. 104, and therefore the adoption of SAB No. 104 did not have a material effect on the Company’s results of operations or financial condition.

 

10


 

In January 2003, the FASB issued FASB Interpretation No. (“FIN”) 46, “Consolidation of Variable Interest Entities” (“FIN 46”). In December 2003, FIN 46 was replaced by FASB interpretation No. 46(R) “Consolidation of Variable Interest Entities.” FIN 46(R) clarifies the application of Accounting Research Bulletin No. 51, “Consolidated Financial Statements,” to certain entities in which equity investors do not have the characteristics of a controlling financial interest or do not have sufficient equity at risk for the entity to finance its activities without additional subordinated financial support from other parties. FIN 46(R) requires an enterprise to consolidate a variable interest entity if that enterprise will absorb a majority of the entity’s expected losses, is entitled to receive a majority of the entity’s expected residual returns, or both. FIN 46(R) is effective for entities being evaluated under FIN 46(R) for consolidation no later than the end of the first reporting period that ends after March 15, 2004. The Company does not currently have any variable interest entities that will be impacted by adoption of FIN 46(R).
Income Taxes
Income taxes are recorded in accordance with SFAS No. 109, Accounting for Income Taxes , which requires the use of the liability method for deferred income taxes.
Use of Estimates
The preparation of the financial statements in conformity with accounting principles generally accepted in the United States requires management to make estimates and assumptions that affect the reported amounts of assets and liabilities and disclosure of contingent assets and liabilities at the date of the financial statements. Actual results could differ from those estimates.
2.  
Property and Equipment
Property and equipment consists of the following:
                 
    December 31  
    2005     2004  
Machinery and equipment
  $ 115,516     $ 5,474  
Computer equipment
    10,887       66,993  
Furniture and fixtures
    4,117       3,984  
Leasehold improvements
    9,906       7,076  
 
           
 
    140,426       83,527  
Accumulated depreciation and amortization
    (38,840 )     (17,308 )
 
           
Property and equipment, net
  $ 101,586     $ 66,219  
 
           
3.  
Patent licenses
At December 31, 2005 and September 30, 2006, the Company had patent licenses recorded at cost of $750,325 and $750,975 respectively. Patent licenses are amortized on a straight line basis over their useful lives.
On December 31, 2003, Lifeline entered into an Option to License Intellectual Property agreement with Advanced Cell Technology, Inc. (“ACT”) for patent rights and paid ACT $340,000 in option and license fees.
On February 13, 2004, Lifeline and ACT amended the Option agreement and Lifeline paid ACT additional option fees of $22,500 for fees related to registering ACT’s patents in selected international countries.
On May 14, 2004, Lifeline amended the licensing agreement with ACT for the exclusive worldwide patent rights for the following ACT technologies: Infigen IP, UMass IP and ACT IP, which terms are summarized below. The license fees aggregate a total of $400,000 and are secured by separate convertible promissory notes. The notes bear no interest unless they are not repaid at maturity, in which event they shall thereafter bear interest at an annual rate equal the lesser of 10% or the maximum non-usurious rate legally allowed.

 

11


 

The notes shall be automatically converted into the first equity financing of Lifeline with cash proceeds in excess of $5,000,000 under the following conditions: i) Upon the consummation of the First Equity Financing; or ii) Immediately prior to the closing of any merger, sale or other consolidation of the Company or of any sale of all or substantially all assets of the Company which occurs prior to the First Equity Financing (an “Acquisition Event”). Notwithstanding the above, and only in the event that a conversion resulting from such Acquisition Event would result in a security not traded on a national stock exchange (including NASDAQ and NASDAQ small cap), upon written notice to the Company not later than five days after the consummation of the Acquisition Event and notice of the Acquisition Event to the Holder of the Note, the Holder may elect to receive payment in cash of the entire outstanding principal of this Note.
                         
    Infigen IP     UMass IP     ACT IP  
License fee
  $ 25,000     $ 150,000     $ 225,000  
Royalty rates
    6%     3% to 12%     3% to 10%  
Minimum royalties
                       
At 12 months
  $ 7,500     $ 15,000     $ 15,000  
At 24 months
  $ 7,500     $ 30,000     $ 37,500  
At 36 months
  $ 6,875     $ 45,000     $ 60,625  
Annually thereafter
  $ 15,000     $ 60,000     $ 75,000  
Milestone payments
                       
First commercial product
  $ 250,000     $ 250,000     $ 250,000  
Sales reaching $5,000,000
  $ 500,000     $ 500,000     $ 500,000  
Sales reaching $10,000,000
  $ 1,000,000     $ 1,000,000     $ 1,000,000  
4.  
Related party payables
The Company has incurred obligations to the following related parties:
                 
    December 31,  
    2004     2005  
Management fee
  $ 495,364     $ 496,159  
SeaCrest Capital
    21,539       19,419  
SeaCrest Partners
    33,378       13,990  
YKA Partners
    62,760       32,779  
Gregory Keller
    62,064       69,717  
Janus Biologics, LLC
    24,750       41,733  
 
           
 
  $ 699,855     $ 673,797  
 
           
The management fee is paid to Mr. Adams and Mr. Aldrich, who are managing members of the Company and control 24.4% of the membership units, for management of the company since inception at $10,000 per month plus accrued interest at 10% per annum on the unpaid balance. Effective June 1, 2006 the management fee was increased to $20,000 per month.
SeaCreast Capital and SeaCreast Partners are controlled by Mr. Adams and Mr. Aldrich, YKA Partners is controlled by Mr. Aldrich and the amounts represent advances to the Company for operating expenses. Gregory Keller controls 12.2% of the membership units and the amounts represent advances to the Company for operating expenses. Janus Biologics, LLC is controlled by Jeffrey Janus who controls 12.5% of the membership units and the amounts represent advances to the Company for operating expenses.

 

12


 

5.  
Promissory Note
The convertible promissory note in the amount of $400,000 issued in payment for patent licenses (see Note 3.) is reduced by a discount in the amount of $25,694 to reflect a 10% fair market rate of interest that will be reflected as interest expense over the remaining term of the note.
6.  
Income Taxes
The Company is a Limited Liability Company and is exempt from Federal and most State income taxes. The net income or loss is passed through annually to the members and any related tax is their individual responsibility. The Company incurs state franchise taxes that are based on income and are included on the statement of operations as provision for income taxes.
7.  
Members’ Contributions
We are authorized to issue membership units to qualified investors which are recorded as members’ contributions on the balance sheet. Members’ contributions at December 31, 2004 and 2005 were $1,655,000 and $2,435,000, respectively. Members have voting rights to elect managing members proportionate to their respective contribution.
9.  
Commitments and Contingencies
Leases
The Company leases office space under a noncancelable operating lease. Future minimum lease payments required under operating leases that have initial or remaining noncancelable lease terms in excess of one year as of December 31, 2005, are as follows:
         
    Amount  
2006
  $ 36,794  
2007
    149,668  
2008
    154,158  
2009
    113,859  
2010 and thereafter
    158,933  
 
     
Total
  $ 613,412  
 
     
10.  
Subsequent Events
On July 1, 2005, Lifeline entered into a Share Exchange Agreement between American Stem Cell Corporation (“ASC”), Lifeline and members of Lifeline. Pursuant to the terms of the Agreement, if the transaction was not completed by December 31, 2005 then the contract was cancelled by its own terms. On June 30, 2006 Lifeline and ASC formally terminated the Agreement with the following provisions 1) Lifeline returned all of the fifteen million five hundred shares of ASC stock to ASC and 2) Lifeline issued a promissory note for $500,000 to ASC in recognition of the cash advances and other services that ASC had provided to Lifeline. The term of the promissory note specifies a maturity date of June 30, 2007 and that early repayments are required when Lifeline consummates equity financing in excess of $2,000,000 prior to the maturity date, Lifeline shall make partial early repayment of the note in an amount equal to 10% of such financing up to the amount of $500,000. No payments are due until the final closing of such financing or the maturity date of the promissory note, whichever comes first.
On November 7, 2006 Lifeline entered into a Share Exchange Agreement (the “ISC Agreement”) between Lifeline, International Stem Cell Corporation (International) and the holders of membership units and warrants for the purchase of membership interests of Lifeline. Pursuant to the terms of the Agreement all the membership units in Lifeline were exchanged for 20,000,000 shares of International $0.001 par value Common Stock and for International’s assumption of Lifeline’s obligations under the warrants. Lifeline became a wholly owned subsidiary of International.

 

13


 

In November and December 2006 International raised $9,630,651, net of fees and commissions, in the sale of 11,205,950 shares of common stock in a private placement. In addition to the funds raised in the private placement, International sold 344,778 shares of its common stock for $310,300 prior to September 30, 2006 and an additional 210,774 shares of its common stock in the amount of $189,700 in November and December 2006.
In December 2006 the Company repaid the $500,000 note payable to ASC and the $400,000 note payable to ACT.

 

14

 

Exhibit 99.3
 
Financial Statements
Lifeline Cell Technology, LLC
(A Development Stage Company)
Nine Months ended September 30, 2006 and September 30, 2005
(Unaudited)
         
 
       
Balance Sheets
    2  
 
       
Statements of Operations
    3  
 
       
Statements of Members’ Equity
    4  
 
       
Statements of Cash Flows
    5  
 
       
Notes to Financial Statements
    4  

 

1


 

Financial Statements
Lifeline Cell Technology, LLC
(A Development Stage Company)
Balance Sheets
(unaudited)
                 
    September 30,  
    2006     2005  
Assets
               
Current assets
               
Cash and cash equivalents
  $ 43,656     $ 197,856  
Receivable from affiliated company International Stem Cell Corporation
    55,334        
Other current assets
    11,926        
 
           
Total current assets
    110,916       197,856  
Property and equipment, net
    117,514       91,701  
Patent licenses, net
    680,460       728,888  
Deposits and other assets
    21,223       2,025  
 
           
Total assets
  $ 930,113     $ 1,020,470  
 
           
Liabilities and members’ equity
               
Current liabilities
               
Accounts payable
  $ 192,342     $ 26,488  
Accrued expenses
    63,255       14,912  
Promissory note
    500,000       400,000  
Payable to affiliated company International Stem Cell Corporation
    310,300        
Related party payables
    599,310       630,373  
 
           
Total current liabilities
    1,665,207       1,071,773  
Promissory notes
    1,121,647       338,827  
 
           
Total liabilities
    2,786,854       1,410,600  
Members’ equity
               
Additional paid-in capital
    1,315,457        
Members’ contribution
    2,685,000       2,435,000  
Accumulated deficit
    (5,857,198 )     (2,825,130 )
 
           
Total members’ equity
    (1,856,741 )     (390,130 )
 
           
Total liabilities and members’ equity
  $ 930,113     $ 1,020,470  
 
           
See accompanying notes

 

2


 

Financial Statements
Lifeline Cell Technology, LLC
(A Development Stage Company)
Statements of Operations
(unaudited)
                         
                    Inception  
                    (August 2001)  
    Nine Months Ended     through  
    September 30,     September 30,  
    2006     2005     2006  
Sales
  $ 1,745             $ 1,903  
Cost of sales
    19,827               19,874  
 
                   
Gross profit
    (18,082 )             (17,971 )
Development expenses
                       
Research and development
    735,499     $ 540,303       2,732,822  
Marketing
    22,279       17,428       60,803  
General and administrative
    1,584,729       309,120       2,630,106  
 
                 
Total development expenses
    2,342,507       866,851       5,423,731  
 
                 
Loss from development activities
    (2,360,589 )     (866,851 )     (5,441,702 )
Other income (expense)
                       
Settlement with related party - American Stem Cell
    (93,333 )           (93,333 )
Miscellaneous Income
    260       4,985       5,305  
Interest Income
    8       245       452  
Interest Expense
    (117,939 )     (63,049 )     (338,107 )
Sublease income
    6,300       5,700       14,987  
 
                 
Total other expense
    (204,704 )     (52,119 )     (410,696 )
 
                 
Loss before income taxes
    (2,565,293 )     (918,970 )     (5,852,398 )
Provision for income taxes
    800       800       4,800  
 
                 
Net loss
  ($ 2,566,093 )   ($ 919,770 )   ($ 5,857,198 )
 
                 
See accompanying notes

 

3


 

Financial Statements
Lifeline Cell Technology, LLC
(A Development Stage Company)
Statements of Members’ Equity
(unaudited)
                                 
    Additional                    
    paid-in     Members     Accumulated        
    capital     contributions     deficit     Total  
Activity through December 31, 2001
        $ 100,000     ($ 140,996 )   ($ 40,996 )
Members contributions
          250,000               250,000  
Net loss
                  (390,751 )     (390,751 )
 
                       
Balance at December 31, 2002
            350,000       (531,747 )     (181,747 )
Members contributions
          195,000               195,000  
Net loss
                  (518,895 )     (518,895 )
 
                       
Balance at December 31, 2003
          545,000       (1,050,642 )     (505,642 )
Members contributions
          1,110,000               1,110,000  
Net loss
                  (854,718 )     (854,718 )
 
                       
Balance at December 31, 2004
          1,655,000       (1,905,360 )     (250,360 )
Members contributions
          780,000               780,000  
Net loss
                  (1,385,745 )     (1,385,745 )
 
                       
Balance at December 31, 2005
          2,435,000       (3,291,105 )     (856,105 )
Warrants issued for services
  $ 807,883                   807,883  
Warrants issued with promissory notes
    507,574                   507,574  
Members contribution
          250,000             250,000  
Net loss (unaudited)
                (2,566,093 )     (2,566,093 )
 
                       
Balance at September 30, 2006
  $ 1,315,457     $ 2,685,000     ($ 5,857,198 )   ($ 1,856,741 )
 
                       
See accompanying notes

 

4


 

Lifeline Cell Technology, LLC
(A Development Stage Company)
Statements of Cash Flows
(unaudited)
                         
                    Inception  
                    (August 2001)  
    Nine Months ended     through  
    September 30,     September 30,  
    2006     2005     2006  
Net loss
  ($ 2,566,093 )   ($ 919,770 )   ($ 5,857,198 )
Adjustments to reconcile net loss to net cash used in operating activities:
                       
Depreciation and amortization
    138,020       36,402       215,317  
Warrants issued for services provided
    807,883             807,883  
Changes in operating assets and liabilities:
                       
Decrease in other current assets
    142             142  
Increase in accounts receivable
                (218 )
Increase in inventories
    (11,850 )           (11,850 )
Increase in deposits
    (19,198 )           (21,223 )
Increase in accounts payable
    148,518       22,057       192,342  
Increase (decrease) in accrued expenses
    17,862       (41,396 )     63,254  
Increase in payable to affiliated company
    254,966             254,966  
Increase (decrease) in related party payables
    (74,487 )     (69,482 )     599,311  
 
                 
Net cash used in operating activities
    (1,304,237 )     (972,189 )     (3,757,274 )
 
                 
Investing activities
                       
Purchases of property and equipment
    (37,618 )     (41,144 )     (183,318 )
Payments for patent licenses
    (650 )     (2,932 )     (750,976 )
 
                 
Net cash used in investing activities
    (38,268 )     (44,076 )     (934,294 )
 
                 
Financing activities
                       
Proceeds from members’ contribution
    250,000       780,000       2,685,000  
Promissory notes (net)
    (100,000 )           (100,000 )
Issuance of convertible notes payable
          424,385       947,368  
Issuance of bridge notes payable
    1,202,856             1,202,856  
 
                 
Net cash provided by financing activities
    1,352,856       1,204,385       4,735,224  
 
                 
Net (decrease) increase in cash and cash equivalents
    10,351       188,120       43,656  
Cash and cash equivalents at beginning of period
    33,305       9,736        
 
                 
Cash and cash equivalents at end of period
  $ 43,656     $ 197,856     $ 43,656  
 
                 
Supplemental disclosures of cash flow information
                       
Cash paid for taxes
  $ 800     $ 800     $ 4,800  
 
                 
See accompanying notes

 

5


 

Lifeline Cell Technology, LLC
(A Development Stage Company)
Notes to financial statements
1.  
Organization and Significant Accounting Policies
Organization
Lifeline Cell Technology, LLC (“Lifeline”) was formed in the State of California on August 17, 2001. Lifeline is in the business of developing and manufacturing human embryonic stem cells and reagents free from animal protein contamination. Lifeline’s scientists have used a technology, called basal medium optimization to systematically eliminate animal proteins from cell culture systems. Lifeline is unique in the industry in that it has in place scientific and manufacturing staff with the experience and knowledge to set up systems and facilities to produce a source of consistent, standardized, animal protein free ES cell products suitable for FDA approval.
Going Concern
The Company continues in the development stage and as such has accumulated losses from inception and expects to incur additional losses in the near future. In addition, the Company has a working capital deficiency as of September 30, 2006. To sustain operations throughout 2006 and 2007, the Company needs to obtain additional capital. Without obtaining such additional capital, there is substantial doubt about the Company’s ability to continue as a going concern. The financial statements do not include any adjustments to reflect the possible future effects on the recoverability and classification of assets or the amounts and classification of liabilities that may result from the outcome of this uncertainty.
Management’s plans in regard to these matters are focused on going public.
There can be no assurance that the Company will be successful in completing any of the above noted transactions or agreements or, if completed, that such transactions or agreements will result in cash flow sufficient to sustain the Company’s operations through 2006 or 2007.
Cash Equivalents
The Company considers all highly liquid investments with a maturity of three months or less when purchased to be cash equivalents.
Short-Term Investments
Management determines the appropriate classification of marketable securities at the time of purchase, and has classified all short-term investments as available-for-sale. Such securities are stated at fair value, with the unrealized gains and losses reported as a separate component of equity. Fair value is determined based on quoted market prices.
Property and Equipment
Property and equipment are stated at cost. The provision for depreciation and amortization is computed using the straight-line method over the estimated useful lives of the assets, which generally range from three to five years. The costs of major remodeling and leasehold improvements are capitalized and depreciated over the shorter of the remaining term of the lease or the life of the asset.
Long-Lived Asset Impairment
The Company reviews long-lived assets for impairment when events or changes in business conditions indicate that their carrying value may not be recovered. The Company considers assets to be impaired and writes them down to fair value if expected associated cash flows are less than the carrying amounts. Fair value is the present value of the associated cash flows. The Company has determined that no material long-lived assets are impaired at September 30, 2006.

 

6


 

Recent Accounting Pronouncements
In October 2006, the Emerging Issues Task Force (“EITF”) issued EITF 06-3, “How Taxes Collected from Customers and Remitted to Governmental Authorities Should Be Presented in the Income Statement (That is, Gross versus Net Presentation)” to clarify diversity in practice on the presentation of different types of taxes in the financial statements. The Task Force concluded that, for taxes within the scope of the issue, a company may adopt a policy of presenting taxes either gross within revenue or net. That is, it may include charges to customers for taxes within revenues and the charge for the taxes from the taxing authority within cost of sales, or, alternatively, it may net the charge to the customer and the charge from the taxing authority. If taxes subject to EITF 06-3 are significant, a company is required to disclose its accounting policy for presenting taxes and the amounts of such taxes that are recognized on a gross basis. The guidance in this consensus is effective for the first interim reporting period beginning after December 15, 2006 (the first quarter of our fiscal year 2007). We do not expect the adoption of EITF 06-3 will have a material impact on our results of operations, financial position or cash flow.
In September 2006, the United States Securities and Exchange Commission (SEC) issued Staff Accounting Bulletin No. 108, “Considering the Effects of Prior Year Misstatements when Quantifying Misstatements in Current Year Financial Statements” (“SAB 108”). This SAB provides guidance on the consideration of the effects of prior year misstatements in quantifying current year misstatements for the purpose of a materiality assessment. SAB 108 establishes an approach that requires quantification of financial statement errors based on the effects on each of the company’s balance sheets, statements of operations and related financial statement disclosures. The SAB permits existing public companies to record the cumulative effect of initially applying this approach in the first year ending after November 15, 2006 by recording the necessary correcting adjustments to the carrying values of assets and liabilities as of the beginning of that year with the offsetting adjustment recorded to the opening balance of retained earnings. Additionally, the use of the cumulative effect transition method requires detailed disclosure of the nature and amount of each individual error being corrected through the cumulative adjustment and how and when it arose. The Company is currently evaluating the impact SAB 108 may have on its results of operations and financial condition.
In September 2006, the FASB issued SFAS No. 158, “Employer’s accounting for Defined Benefit Pension and Other Post Retirement Plans”. SFAS No. 158 requires employers to recognize in its statement of financial position an asset or liability based on the retirement plan’s over or under funded status. SFAS No. 158 is effective for fiscal years ending after December 15, 2006. The Company is currently evaluating the effect that the application of SFAS No. 158 will have on its results of operations and financial condition.
In September 2006, the Financial Accounting Standards Board (FASB) issued Statement of Financial Accounting Issues No. 157, “Fair Value Measurements” (“SFAS 157”), which defines the fair value, establishes a framework for measuring fair value and expands disclosures about fair value measurements. This statement is effective for financial statements issued for fiscal years beginning after November 15, 2007, and interim periods within those fiscal years. Early adoption is encouraged, provided that the Company has not yet issued financial statements for that fiscal year, including any financial statements for an interim period within that fiscal year. The Company is currently evaluating the impact SFAS 157 may have on its financial condition or results of operations.
In July 2006, the FASB released FASB Interpretation No. 48, Accounting for Uncertainty in Income Taxes, an interpretation of FASB Statement No. 109 (FIN 48). FIN 48 clarifies the accounting and reporting for uncertainties in income tax law. This interpretation prescribes a comprehensive model for the financial statement recognition, measurement, presentation and disclosure of uncertain tax positions taken or expected to be taken in income tax returns. This statement is effective for fiscal years beginning after December 15, 2006. The Company is currently evaluating the impact FIN 48 may have on its financial condition or results of operations.

 

7


 

In March 2006, the FASB issued SFAS No. 156, “Accounting for Servicing of Financial Assets” (“SFAS NO. 156”), which provides an approach to simplify efforts to obtain hedge-like (offset) accounting. This Statement amends FASB Statement No. 140, “Accounting for Transfers and Servicing of Financial Assets and Extinguishments of Liabilities”, with respect to the accounting for separately recognized servicing assets and servicing liabilities. The Statement (1) requires an entity to recognize a servicing asset or servicing liability each time it undertakes an obligation to service a financial asset by entering into a servicing contract in certain situations; (2) requires that a separately recognized servicing asset or servicing liability be initially measured at fair value, if practicable; (3) permits an entity to choose either the amortization method or the fair value method for subsequent measurement for each class of separately recognized servicing assets or servicing liabilities; (4) permits at initial adoption a one-time reclassification of available-for-sale securities to trading securities by an entity with recognized servicing rights, provided the securities reclassified offset the entity’s exposure to changes in the fair value of the servicing assets or liabilities; and (5) requires separate presentation of servicing assets and servicing liabilities subsequently measured at fair value in the balance sheet and additional disclosures for all separately recognized servicing assets and servicing liabilities. SFAS No. 156 is effective for all separately recognized servicing assets and liabilities as of the beginning of an entity’s fiscal year that begins after September 15, 2006, with earlier adoption permitted in certain circumstances. The Statement also describes the manner in which it should be initially applied. The Company does not believe that SFAS No. 156 will have a material impact on its financial position, results of operations or cash flows.
In February 2006, the FASB issued SFAS No. 155, “Accounting for Certain Hybrid Financial Instruments”, which amends SFAS No. 133, “Accounting for Derivatives Instruments and Hedging Activities” and SFAS No. 140, “Accounting for Transfers and Servicing of Financial Assets and Extinguishment of Liabilities”. SFAS No. 155 amends SFAS No. 133 to narrow the scope exception for interest-only and principal-only strips on debt instruments to include only such strips representing rights to receive a specified portion of the contractual interest or principle cash flows. SFAS No. 155 also amends SFAS No. 140 to allow qualifying special-purpose entities to hold a passive derivative financial instrument pertaining to beneficial interests that itself is a derivative instrument. The Company is currently evaluating this new Standard but cannot determine the future impact as the Company does not have any “Derivatives Instruments and Hedging Activities”, but may implement them in the future.
In November 2005, the FASB issued FSP FAS 115-1 and FAS 124-1, “The Meaning of Other-Than-Temporary Impairment and Its Application to Certain Investments” (“FSP 115-1 and 124-1”), which clarifies when an investment is considered impaired, whether the impairment is other-than-temporary, and the measurement of an impairment loss. It also includes accounting considerations subsequent to the recognition of the other-than-temporary impairment and requires certain disclosures about unrealized losses that have not been recognized as other-than-temporary impairments. FSP 115-1 and 124-1 are effective for all reporting periods beginning after December 15, 2005. The Company does not anticipate that the implementation of these statements will have a significant impact on its financial position, results of operations or cash flows.
In May 2005, the FASB issued SFAS No. 154, “Accounting Changes and Error Corrections” (“SFAS No. 154”). SFAS No. 154 is a replacement of Accounting Principles Board Opinion No. 20 and SFAS No. 3. SFAS No. 154 provides guidance on the accounting for and reporting of accounting changes and error corrections. It establishes retrospective application as the required method for reporting a change in accounting principle. SFAS No. 154 provides guidance for determining whether retrospective application of a change in accounting principle is impracticable and for reporting a change when retrospective application is impracticable. SFAS No. 154 also addresses the reporting of a correction of an error by restating previously issued financial statements. SFAS No 154 is effective for accounting changes and corrections of errors made in fiscal years beginning after December 15, 2005. The Company does not believe that it will have a material impact on its financial position, results of operations or cash flows.
In December 2004, the Financial Accounting Standards Board (“FASB”) issued SFAS No. 153, “Exchanges of Nonmonetary Assets, an amendment of APB Opinion No. 29, Accounting for Nonmonetary Transactions.” The amendments made by Statement 153 are based on the principle that exchanges of nonmonetary assets should be measured based on the fair value of the assets exchanged. Further, the amendments eliminate the narrow exception for nonmonetary exchanges of similar productive assets and replace it with a broader exception for exchanges of nonmonetary assets that do not have commercial substance. Previously, Opinion 29 required that the accounting for an exchange of a productive asset for a similar productive asset or an equivalent interest in the same or similar productive asset should be based on the recorded amount of the asset relinquished. Opinion 29 provided an exception to its basic measurement principle (fair value) for exchanges of similar productive assets. The FASB believes that exception required that some nonmonetary exchanges, although commercially substantive, be recorded on a carryover basis. By focusing the exception on exchanges that lack commercial substance, the FASB believes this statement produces financial reporting that more faithfully represents the economics of the transactions. SFAS 153 is effective for nonmonetary asset exchanges occurring in fiscal periods beginning after June 15, 2005. Earlier application is permitted for nonmonetary asset exchanges occurring in fiscal periods beginning after the date of issuance. The provisions of SFAS 153 shall be applied prospectively. The Company has evaluated the impact of the adoption of SFAS 153, and does not believe the impact will be significant to the Company’s overall results of operations or financial position.

 

8


 

In December 2004, the FASB issued SFAS No. 123 (revised 2004), “Share-Based Payment”. SFAS 123(R) will provide investors and other users of financial statements with more complete and neutral financial information by requiring that the compensation cost relating to share-based payment transactions be recognized in financial statements. That cost will be measured based on the fair value of the equity or liability instruments issued. SFAS 123(R) covers a wide range of share-based compensation arrangements including share options, restricted share plans, performance-based awards, share appreciation rights, and employee share purchase plans. SFAS 123(R) replaces FASB Statement No. 123, “Accounting for Stock-Based Compensation”, and supersedes APB Opinion No. 25, “Accounting for Stock Issued to Employees”. SFAS 123, as originally issued in 1995, established as preferable a fair-value-based method of accounting for share-based payment transactions with employees. However, that statement permitted entities the option of continuing to apply the guidance in Opinion 25, as long as the footnotes to financial statements disclosed what net income would have been had the preferable fair-value-based method been used. Public entities (other than those filing as small business issuers) will be required to apply SFAS 123(R) as of the first interim or annual reporting period that begins after June 15, 2005. SFAS 123(R) is applicable for ASC effective the first interim period that starts after July 1, 2005. The Company has evaluated the impact of the adoption of SFAS 123(R), and cannot determine the future impact as the Company does not have any “Share Based Payment” compensations programs, but may implement them in the future.
In November 2004, the FASB issued SFAS No. 151, “Inventory Costs, an amendment of ARB No. 43, Chapter 4”. The amendments made by Statement 151 clarify that abnormal amounts of idle facility expense, freight, handling costs, and wasted materials (spoilage) should be recognized as current period charges and require the allocation of fixed production overheads to inventory based on the normal capacity of the production facilities. The guidance is effective for inventory costs incurred during fiscal years beginning after June 15, 2005. Earlier application is permitted for inventory costs incurred during fiscal years beginning after November 23, 2004. The Company has evaluated the impact of the adoption of SFAS 151, and does not believe the impact will be significant to the Company’s overall results of operations or financial position since the Company does not currently have any manufacturing operations or inventory.
In March 2004, the FASB approved the consensus reached on the Emerging Issues Task Force (EITF) Issue No. 03-1, “The Meaning of Other-Than-Temporary Impairment and Its Application to Certain Investments.” The objective of this Issue is to provide guidance for identifying impaired investments. EITF 03-1 also provides new disclosure requirements for investments that are deemed to be temporarily impaired. The accounting provisions of EITF 03-1 are effective for all reporting periods beginning after June 15, 2004, while the disclosure requirements for certain investments are effective for annual periods ending after December 15, 2003, and for other investments such disclosure requirements are effective for annual periods ending after June 15, 2004.
In December 2003, the SEC issued Staff Accounting Bulletin (“SAB”) No. 104 (“SAB No. 104”), “Revenue Recognition.” SAB No. 104 supersedes SAB No. 101, “Revenue Recognition in Financial Statements.” SAB No. 104, which was effective upon issuance, rescinded certain guidance contained in SAB No. 101 related to multiple element revenue arrangements, and replaced such guidance with that contained in EITF 00-21, “Accounting for Revenue Arrangements with Multiple Deliverables.” Additionally, SAB No. 104 rescinded the SEC’s Revenue Recognition in Financial Statements Frequently Asked Questions and Answers issued with SAB No. 101. The revenue recognition principles of SAB No. 101 remain largely unchanged by the issuance of SAB No. 104, and therefore the adoption of SAB No. 104 did not have a material effect on the Company’s results of operations or financial condition.

 

9


 

In January 2003, the FASB issued FASB Interpretation No. (“FIN”) 46, “Consolidation of Variable Interest Entities” (“FIN 46”). In December 2003, FIN 46 was replaced by FASB interpretation No. 46(R) “Consolidation of Variable Interest Entities.” FIN 46(R) clarifies the application of Accounting Research Bulletin No. 51, “Consolidated Financial Statements,” to certain entities in which equity investors do not have the characteristics of a controlling financial interest or do not have sufficient equity at risk for the entity to finance its activities without additional subordinated financial support from other parties. FIN 46(R) requires an enterprise to consolidate a variable interest entity if that enterprise will absorb a majority of the entity’s expected losses, is entitled to receive a majority of the entity’s expected residual returns, or both. FIN 46(R) is effective for entities being evaluated under FIN 46(R) for consolidation no later than the end of the first reporting period that ends after March 15, 2004. The Company does not currently have any variable interest entities that will be impacted by adoption of FIN 46(R).
Income Taxes
Income taxes are recorded in accordance with SFAS No. 109, Accounting for Income Taxes , which requires the use of the liability method for deferred income taxes.
Use of Estimates
The preparation of the financial statements in conformity with accounting principles generally accepted in the United States requires management to make estimates and assumptions that affect the reported amounts of assets and liabilities and disclosure of contingent assets and liabilities at the date of the financial statements. Actual results could differ from those estimates.
2.  
Property and Equipment
Property and equipment consists of the following:
                 
    September 30,  
    2006     2005  
Machinery and equipment
  $ 138,075     $ 104,238  
Computer equipment
    17,247       6,410  
Furniture and fixtures
    7,349       4,117  
Leasehold improvements
    15,373       9,906  
 
           
 
    178,044       124,671  
Accumulated depreciation and amortization
    (60,530 )     (32,970 )
 
           
 
  $ 117,514     $ 91,701  
 
           
3.  
Patent licenses
At September 30, 2006 and September 30, 2005, the Company had patent licenses recorded at cost of $750,975 and $749,628 respectively. Patent licenses are amortized on a straight line basis over their useful lives.
On December 31, 2003, Lifeline entered into an Option to License Intellectual Property agreement with Advanced Cell Technology, Inc. (“ACT”) for patent rights and paid ACT $340,000 in option and license fees.
On February 13, 2004, Lifeline and ACT amended the Option agreement and Lifeline paid ACT additional option fees of $22,500 for fees related to registering ACT’s patents in selected international countries.
On May 14, 2004, Lifeline amended the licensing agreement with ACT for the exclusive worldwide patent rights for the following ACT technologies: Infigen IP, UMass IP and ACT IP, which terms are summarized below. The license fees aggregate a total of $400,000 and are secured by separate convertible promissory notes. The notes bear no interest unless they are not repaid at maturity, in which event they shall thereafter bear interest at an annual rate equal the lesser of 10% or the maximum non-usurious rate legally allowed.

 

10


 

The notes shall be automatically converted into the first equity financing of Lifeline with cash proceeds in excess of $5,000,000 under the following conditions: i) Upon the consummation of the First Equity Financing; or ii) Immediately prior to the closing of any merger, sale or other consolidation of the Company or of any sale of all or substantially all assets of the Company which occurs prior to the First Equity Financing (an “Acquisition Event”). Notwithstanding the above, and only in the event that a conversion resulting from such Acquisition Event would result in a security not traded on a national stock exchange (including NASDAQ and NASDAQ small cap), upon written notice to the Company not later than five days after the consummation of the Acquisition Event and notice of the Acquisition Event to the Holder of the Note, the Holder may elect to receive payment in cash of the entire outstanding principal of this Note.
                         
    Infigen IP     UMass IP     ACT IP  
License fee
  $ 25,000     $ 150,000     $ 225,000  
Royalty rates
    6%     3% to 12%     3% to 10%  
Minimum royalties
                       
At 12 months
  $ 7,500     $ 15,000     $ 15,000  
At 24 months
  $ 7,500     $ 30,000     $ 37,500  
At 36 months
  $ 6,875     $ 45,000     $ 60,625  
Annually thereafter
  $ 15,000     $ 60,000     $ 75,000  
Milestone payments
                       
First commercial product
  $ 250,000     $ 250,000     $ 250,000  
Sales reaching $5,000,000
  $ 500,000     $ 500,000     $ 500,000  
Sales reaching $10,000,000
  $ 1,000,000     $ 1,000,000     $ 1,000,000  
4.  
Related party payables
The Company has incurred obligations to the following related parties:
                 
    September 30,  
    2006     2005  
Management fee
  $ 474,984     $ 497,185  
SeaCrest Capital
    20,762       18,971  
SeaCrest Partners
    14,925       13,678  
YKA Partners
    34,382       32,154  
Gregory Keller
    23,601       62,064  
Janus Biologics, LLC
    30,656       6,321  
 
           
 
  $ 599,310     $ 630,373  
 
           
The management fee is paid to Mr. Adams and Mr. Aldrich, who are managing members of the Company and control 24.4% of the membership units, for management of the company since inception at $10,000 per month plus accrued interest at 10% per annum on the unpaid balance. Effective June 1, 2006 the management fee was increased to $20,000 per month.
SeaCreast Capital and SeaCreast Partners are controlled by Mr. Adams and Mr. Aldrich, YKA Partners is controlled by Mr. Aldrich and the amounts represent advances to the Company for operating expenses. Gregory Keller controls 12.2% of the membership units and the amounts represent advances to the Company for operating expenses. Janus Biologics, LLC is controlled by Jeffrey Janus who controls 12.5% of the membership units and the amounts represent advances to the Company for operating expenses.

 

11


 

5.  
Promissory Notes
In connection with the loans of $1,202,856, the Company issued 10% promissory notes payable, due April 1, 2008 and warrants granting the holders the right to acquire 1,202,856 shares as follows; If the shareholders of Lifeline have received shares of stock in a corporation in exchange for Lifeline shares of Membership Interest (or pursuant to other corporate merger or consolidation) pursuant to which Lifeline is merged into or becomes a subsidiary of a public corporation in connection with a financing arrangement generating at least $2 million of operating capital for Lifeline, each Warrant shall entitle the holder thereof to purchase the number of shares of Common Stock that could be purchased by the dollar amount of the Warrant being exercised at the offering price of the shares sold in the offering (or at the conversion price if the offering is of a convertible security) at a price equal to 80% of the purchase price paid by the investors in such offering. The Company recognized the value attributable to the warrants in the amount of $507,575 and applied it to additional paid-in capital and a discount against the loan. The Company valued the warrants in accordance with EITF 00-27 using the Black-Scholes pricing model and the following assumptions: contractual terms of 3.25 years, an average risk free interest rate of 4.6%, a dividend yield of 0%, and volatility of 40%. The debt discount attributed to the value of the warrants is $507,575 and is amortized over the loan’s maturity period (three and one quarter years) as interest expense. To September 30, 2006 amortization in the amount of $52,059 has been recognized as interest expense.
In addition, the convertible promissory note in the amount of $400,000 issued in payment for patent licenses (see Note 3.) is reduced by a discount in the amount of $25,694 to reflect a 10% fair market rate of interest that will be reflected as interest expense over the remaining term of the note.
6.  
Income Taxes
The Company is a Limited Liability Company and is exempt from Federal and most State income taxes. The net income or loss is passed through annually to the members and any related tax is their individual responsibility. The Company incurs state franchise taxes that are based on income and are included on the statement of operations as provision for income taxes.
7.  
Warrants
In addition to the warrants issued in conjunction with the promissory notes (Note 5. above), during the 9 months ended September 30, 2006 the Company issued 2,000,000 warrants to Brookstreet Securities Corporation as partial compensation for their services as placement agent for the raising of equity capital and 426,767 warrants to a number of individuals as compensation for services rendered to the Company. If the shareholders of Lifeline have received shares of stock in a corporation in exchange for Lifeline shares of Membership Interest (or pursuant to other corporate merger or consolidation) pursuant to which Lifeline is merged into or becomes a subsidiary of a public corporation in connection with a financing arrangement generating at least $2 million of operating capital for Lifeline, each Warrant shall entitle the holder thereof to purchase the number of shares of Common Stock that could be purchased by the dollar amount of the Warrant being exercised at the offering price of the shares sold in the offering (or at the conversion price if the offering is of a convertible security) at a price equal to 100% in the case of the Brookstreet warrants and 80% in the case of the individuals’ warrants, of the purchase price paid by the investors in such offering. The Company recognized the value attributable to the warrants in the amount of $807,883 and applied it to general and administrative expense. The Company valued the warrants in accordance with EITF 00-27 using the Black-Scholes pricing model and the following assumptions: contractual terms of 2.92 years, an average risk free interest rate of 4.6%, a dividend yield of 0%, and volatility of 40%.
8.  
Members’ Contributions
We are authorized to issue membership units to qualified investors which are recorded as members’ contributions on the balance sheet. Members’ contributions at September 30, 2006 and September 30, 2005 were $2,685,000, and $2,435,000, respectively. Members have voting rights to elect managing members proportionate to their respective contribution.

 

12


 

9.  
Commitments and Contingencies
Leases
The Company leases office space under a noncancelable operating lease. Future minimum lease payments required under operating leases that have initial or remaining noncancelable lease terms in excess of one year as of September 30, 2006, are as follows:
         
    Amount  
2006
  $ 36,794  
2007
    149,668  
2008
    154,158  
2009
    113,859  
2010 and thereafter
    158,933  
 
     
Total
  $ 613,412  
 
     
American Stem Cell Corporation (“ASC”)
On July 1, 2005, Lifeline entered into a Share Exchange Agreement (the “ASC Agreement”) between ASC, Lifeline and members of Lifeline. Pursuant to the terms of the ASC Agreement, if the transaction was not completed by December 31, 2005 then the contract was cancelled by its own terms. On June 30, 2006 Lifeline and ASC formally terminated the ASC Agreement with the following provisions 1) Lifeline returned all of the fifteen million five hundred shares of ASC stock to ASC and 2) Lifeline issued a promissory note for $500,000 to ASC in recognition of the cash advances and other services that ASC had provided to Lifeline. The term of the promissory note specifies a maturity date of June 30, 2007 and that early repayments are required when Lifeline consummates equity financing in excess of $2,000,000 prior to the maturity date, Lifeline shall make partial early repayment of the note in an amount equal to 10% of such financing up to the amount of $500,000. No payments are due until the final closing of such financing or the maturity date of the promissory note, whichever comes first.
10.  
Subsequent Events
On November 7, 2006 Lifeline entered into a Share Exchange Agreement (the “ISC Agreement”) between Lifeline, International Stem Cell Corporation (International) and the holders of membership units and warrants for the purchase of membership interests of Lifeline. Pursuant to the terms of the Agreement all the membership units in Lifeline were exchanged for 20,000,000 shares of International $0.001 par value Common Stock and for International’s assumption of Lifeline’s obligations under the warrants. Lifeline became a wholly owned subsidiary of International.
In December, 2006, BTHC III, Inc., a Delaware corporation (“BTHC”) entered into a Share Exchange Agreement (the “Exchange Agreement”) by and among International, Halter Financial Group, Inc. and the shareholders of International by and through the shareholders’ representative named therein. Pursuant to the terms of the Exchange Agreement, BTHC will issue shares of its par value $0.001 per share common stock, in exchange for all of the issued and outstanding stock of International held by the International shareholders. After giving effect to the Share Exchange, the ISC Shareholders will own 93.7 percent of the issued and outstanding shares of BTHC.
In November and December 2006 International raised $9,630,651, net of fees and commissions, in the sale of 11,205,950 shares of common stock in a private placement. In addition to the funds raised in the private placement, International sold 344,778 shares of its common stock for $310,300 prior to September 30, 2006 and an additional 210,774 shares of its common stock in the amount of $189,700 in November and December 2006.
In December 2006 the Company repaid the $500,000 note payable to ASC and the $400,000 note payable to ACT.

 

13

 

Exhibit 99.4
 
International Stem Cell Corporation
Unaudited Pro Forma Financial Information
The following presents our unaudited pro forma financial information for the year ended December 31, 2005 and as of and for the nine months ended September 30, 2006. The pro forma statements of operations for the year ended December 31, 2005 and the nine months ended September 30, 2006 give effect to the combined operations of the three companies, International Stem Cell Corporation (“International”), BTHC III, Inc. (“BTHC”) and Lifeline Cell Technology, LLC (“Lifeline”). The unaudited pro forma balance sheet as of September 30, 2006 has been prepared as if (i) the issuance of 20 million shares of BTHC in exchange for all of the issued and outstanding stock of International held by the International shareholders whereby International became a wholly owned subsidiary of BTHC, (ii) the issue of 1,709,993 shares resulting from the 4.42:1 forward stock split to the pre-existing shareholders of BTHC, (iii) the issue of 555,552 shares in exchange for $500,000 in subscriptions for share received by International, $310,300 as of September 30, 2006 and $187,700 subsequently, (iv) the repayment of $400,000 and $500,000 notes payable in December, (v) the issue of 1,000,000 shares prepayment of a one year services contract and 350,000 shares as compensation for legal services related to the share issue, and (vi) the issue of 11,205,950 shares in exchange for $9,630,651 net of fees, commissions and expenses raised under a private placement memorandum, had occurred on that date. The pro forma adjustments are based upon available information and certain assumptions that we believe are reasonable. The share exchange agreement between BTHC III and International Stem Corporation will be accounted for as a reverse merger. In the reverse merger, BTHC III will be considered the legal acquirer and International Stem Cell Corporation will be considered the accounting acquirer.
The unaudited pro forma financial information is for informational purposes only and does not purport to present what our results would actually have been had these transactions actually occurred on the dates presented or to project our results of operations or financial position for any future period. You should read the information set forth below together with (i) the audited Lifeline financial statements as of December 31, 2004 and 2005 and for each of the years there ended, and the unaudited Lifeline Cell Technology, LLC financial statements as of September 30, 2006 and 2005 and for the nine months there ended, including the notes thereto, included in this report, and (ii) the International audited financial statements as of September 30, 2006 and for the nine month period there ended, including the notes thereto, and (iii) the audited BTHC financial statements as of December 31, 2004 and 2005 included in the BTHC Annual Report on Form 10-SB12GA for the fiscal year ended December 31, 2005, which is incorporated by reference and for each of the years there ended, including the notes thereto, and the unaudited BTHC financial statements as of September 30, 2006 included in the BTHC Quarterly Report on Form 10QSB for the period ended September 30, 2006, which is incorporated by reference, including the notes thereto.

 

1


 

INTERNATIONAL STEM CELL CORPORATION and SUBSIDIARIES
Pro Forma Consolidated Balance Sheet
As at September 30, 2006
                                                 
            Lifeline                                
    International     Cell                             Proforma  
    Stem Cell     Technology,     BTHC     Proforma             Balance  
    Corporation     LLC     III, Inc.     Adjustments             Sheet  
Assets           unaudited     unaudited     unaudited             unaudited  
Current assets
                                               
Cash and cash equivalents
          $ 43,656               9,630,651       (6 )   $ 8,514,007  
 
                            189,700       (8 )        
 
                            (900,000 )     (9 )        
 
                            (450,000 )     (10 )        
Receivable from Lifeline
    310,300                       (310,300 )     (1 )        
Due from International Stemcell
          $ 55,334               (55,334 )     (1 )        
Prepaid stock issue expenses
    68,957                       (68,957 )     (5 )        
Other assets
            11,926               1,000,000       (11 )     1,011,926  
 
                                       
Total current assets
    379,257       110,916                               9,525,933  
Property and equipment, net
            117,514                               117,514  
Patent licenses, net
            680,460                               680,460  
Deposits and other assets
            21,223                               21,223  
 
                                       
Total assets
  $ 379,257     $ 930,113                             $ 10,345,130  
 
                                       
Liabilities and Shareholder’ Equity
                                               
Current liabilities
                                               
Accounts payable
          $ 192,342                             $ 192,342  
Accrued expenses
  $ 104,862       63,255               (25,693 )     (9 )     142,424  
Payable to Lifeline
    55,334                       (55,334 )     (1 )        
Payable to International Stemcell
            310,300               (310,300 )     (1 )        
Promissory note
            500,000             (500,000 )     (9 )      
Related party payables
            599,310     $ 31,549                       630,859  
 
                                       
Total current liabilities
    160,196       1,665,207       31,549                       965,625  
Promissory notes
            1,121,647               (374,307 )     (9 )     747,340  
 
                                       
Total liabilities
    160,196       2,786,854       31,549                       1,712,965  
Stockholders’ equity
                                               
Capital Stock
                    500       1,710       (3 )     35,321  
 
                            20,000       (2 )        
 
                            345       (4 )        
 
                            11,206       (6 )        
 
                            211       (8 )        
 
                            1,000       (11 )        
 
                            350       (12 )        
Additional paid-in capital
    310,300       1,315,457       500       (1,710 )     (3 )     14,545,281  
 
                            2,665,000       (2 )        
 
                            (345 )     (4 )        
 
                            (68,957 )     (5 )        
 
                            9,619,445       (6 )        
 
                            (32,549 )     (7 )        
 
                            189,489       (8 )        
 
                            (450,000 )     (10 )        
 
                            999,000       (11 )        
 
                            (350 )     (12 )        
Members’ contribution
            2,685,000               (2,685,000 )     (2 )        
Retained earnings
    (91,239 )     (5,857,198 )     (32,549 )     32,549       (7 )     (5,948,437 )
 
                                         
Total members’ equity
    219,061       (1,856,741 )     (31,549 )                     8,632,165  
 
                                       
Total liabilities and equity
  $ 379,257     $ 930,113     $                     $ 10,345,130  
 
                                       

 

2


 

Pro Forma Adjustments
(1)  
To eliminate intercompany accounts
 
(2)  
Members’ contributions converted into 20,000,000 shares of common stock
 
(3)  
BTHC III forward split 4.42:1
 
(4)  
Issue of 344,778 subscribed shares in International
 
(5)  
Allocation of stock issue expenses to additional paid-in capital
 
(6)  
Subscriptions for 11,205,950 shares of International in November and December 2006
 
(7)  
Elimination of BTHC deficit
 
(8)  
Issue of 210,774 subscribed shares for cash received in International after September 30, 2006
 
(9)  
Repayment of $500,000 and $400,000 promissory notes
 
(10)  
Payment of fee for public shell company
 
(11)  
1,000,000 shares issued for 1 year future contract
 
(12)  
350,000 shares issued for legal expenses related to the issue of shares
 
(13)  
All shares of common stock of International Stem Cell Corporation are exchanged 1:1 for shares of common stock of BTHC III, Inc.

 

3


 

INTERNATIONAL STEM CELL CORPORATION and SUBSIDIARIES
Pro Forma Unaudited Consolidated Statement of Operations
Nine Months ended September 30, 2006
                                         
    International     Lifeline Cell                     Pro forma  
    Stem Cell     Technology,     BTHC     Pro forma     Statement of  
    Corporation     LLC     III, Inc.     Adjustment     Operations  
            unaudited     unaudited     unaudited     unaudited  
Sales
          $ 1,745                     $ 1,745  
Cost of sales
          19,827                       19,827  
 
                                   
Gross profit
          (18,082 )                 (18,082 )
Expenses
                                       
Research and development
          735,499                   735,498  
Marketing
          22,279                   22,279  
General and administrative
  $ 91,239       1,584,729     $ 24,253     ($ 24,253 )     1,675,968  
 
                             
Total expenses
    91,239       2,342,507       24,253       (24,253 )     2,433,746  
Loss from operations
    (91,239 )     (2,360,589 )     (24,253 )     24,253       (2,451,828 )
Other income (expense)
                                       
Settlement with related company
          (93,333 )                 (93,333 )
Miscellaneous Income
          260                   260  
Interest Income
          8                   8  
Interest Expense
          (117,939 )                 (117,939 )
Sublease income
          6,300                   6,300  
 
                             
Total other expense
          (204,704 )                 (204,704 )
 
                             
Loss before tax
    (91,239 )     (2,565,293 )     (24,253 )     24,253       (2,656,532 )
Provision for taxes
            800                       800  
 
                             
Net loss
  ($ 91,239 )   ($ 2,566,093 )   ($ 24,253 )   $ 24,253     ($ 2,657,332 )
 
                             
Pro Forma Adjustment
Elimination of BTHC III administrative expense

 

4


 

INTERNATIONAL STEM CELL CORPORATION and SUBSIDIARIES
Pro Forma Unaudited Consolidated Statement of Operations
For the Year Ended December 31, 2005
                                         
    International                              
    Stem Cell     Lifeline Cell                     Pro forma  
    Corporation     Technology,     BTHC     Pro forma     Statement of  
    (a)     LLC     III, Inc.     Adjustment     Operations  
            unaudited     unaudited     unaudited     unaudited  
Expenses
                                       
Research and development
        $ 804,191                 $ 804,191  
Marketing
          36,361                   36,361  
General and administrative
          461,523     $ 8,296     ($ 8,296 )     461,523  
 
                             
Total expenses
          1,302,075       8,296       (8,296 )     1,302,075  
Loss from operations
          (1,302,075 )     (8,296 )     8,296       (1,302,075 )
Other income (expense)
                                       
Interest Income
          405                   405  
Interest Expense
          (96,120 )                 (96,120 )
Sublease income
          7,800                   7,800  
Other income
          5,045                   5,045  
 
                             
Total other expense
          (82,870 )                 (82,870 )
 
                             
Loss before tax
          (1,384,945 )     (8,296 )     8,296       (1,384,945 )
Provision for taxes
          800                   800  
 
                             
Net loss
        ($ 1,385,745 )   ($ 8,296 )   $ 8,296     ($ 1,385,745 )
 
                             
Pro Forma Adjustment
Elimination of BTHC III administrative expense
Note
(a) Not formed in 2005

 

5