UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington D.C. 20549
 
FORM 10-Q
 
(Mark One)
x
QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934
For the quarterly period ended  September 30, 2012
OR
o
TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934
For the Transition Period from              to             
Commission File Number: 001-34885
 
AMYRIS, INC.
(Exact name of registrant as specified in its charter)  
Delaware
 
55-0856151
(State or other jurisdiction of
incorporation or organization)
 
(I.R.S. Employer
Identification No.)
Amyris, Inc.
5885 Hollis Street, Suite 100
Emeryville, CA 94608
(510) 450-0761
(Address and telephone number of principal executive offices)
 
Indicate by check mark whether the registrant (1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during the preceding 12 months (or for such shorter period that the registrant was required to file such reports), and (2) has been subject to such filing requirements for the past 90 days.    Yes   x     No   ¨

Indicate by check mark whether the registrant has submitted electronically and posted on its corporate Web site, if any, every Interactive Data File required to be submitted and posted pursuance to Rule 405 of Regulation S-T (§232.405 of this chapter) during the preceding 12 months (or for such shorter period that the registrant was required to submit and post such files).    Yes   x     No   ¨

Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, or a non-accelerated filer.
Large accelerated filer
x
Accelerated filer
¨
 
 
 
 
Non-accelerated filer
¨
Smaller reporting company
¨

Indicate by check mark whether the registrant is a shell company (as defined in Rule 12b-2 of the Exchange Act).    Yes   ¨     No   x

Indicate the number of shares outstanding of each of the issuer’s classes of common stock, as of the latest practicable date.
Class
Outstanding at October 26, 2012
Common Stock, $0.0001 par value per share
59,430,122 shares





AMYRIS, INC.
QUARTERLY REPORT ON FORM 10-Q
For the Quarterly Period Ended September 30, 2012
INDEX
 
 
 
Page
 
PART I - FINANCIAL INFORMATION
 
Item 1.
Item 2.
Item 3.
Item 4.
 
 
 
 
PART II - OTHER INFORMATION
 
Item 1.
Item 1A.
Item 2.
Item 3.
Item 4.
Item 5.
Item 6.
 
 

 

 






PART I - FINANCIAL INFORMATION

ITEM 1. FINANCIAL STATEMENTS

Amyris, Inc.
Condensed Consolidated Balance Sheets
(In Thousands, Except Share and Per Share Amounts)
(Unaudited)
 
 
September 30, 2012
 
December 31, 2011
Assets
 
 
 
Current assets:
 
 
 
Cash and cash equivalents
$
44,373

 
$
95,703

Short-term investments
56

 
7,889

Accounts receivable, net of allowance of $481 and $245, respectively
3,807

 
6,936

Inventories, net
8,311

 
9,070

Prepaid expenses and other current assets
9,995

 
19,873

Total current assets
66,542

 
139,471

Property and equipment, net
164,703

 
128,101

Restricted cash
954

 

Other assets
20,133

 
43,001

Goodwill and intangible assets
9,248

 
9,538

Total assets
$
261,580

 
$
320,111

Liabilities and Equity
 
 
 
Current liabilities:
 
 
 
Accounts payable
$
18,374

 
$
26,379

Deferred revenue
1,532

 
3,139

Accrued and other current liabilities
24,061

 
30,982

Capital lease obligation, current portion
1,871

 
3,717

Debt, current portion
2,121

 
28,049

Total current liabilities
47,959

 
92,266

Capital lease obligation, net of current portion
1,495

 
2,619

Long-term debt, net of current portion
103,289

 
13,275

Deferred rent, net of current portion
8,886

 
9,957

Deferred revenue, net of current portion
4,396

 
4,097

Other liabilities
18,893

 
37,085

Total liabilities
184,918

 
159,299

Commitments and contingencies (Note 5)

 

Stockholders’ equity:
 
 
 
Preferred stock - $0.0001 par value, 5,000,000 shares authorized, none issued and outstanding

 

Common stock - $0.0001 par value, 100,000,000 shares authorized as of September 30, 2012 and December 31, 2011; 59,430,122 and 45,933,138 shares issued and outstanding as of September 30, 2012 and December 31, 2011, respectively
6

 
5

Additional paid-in capital
632,773

 
548,159

Accumulated other comprehensive loss
(12,479
)
 
(5,924
)
Accumulated deficit
(542,835
)
 
(381,188
)
Total Amyris, Inc. stockholders’ equity
77,465

 
161,052

Noncontrolling interest
(803
)
 
(240
)
Total stockholders' equity
76,662

 
160,812

Total liabilities and stockholders' equity
$
261,580

 
$
320,111

See the accompanying notes to the unaudited condensed consolidated financial statements.

1



Amyris, Inc.
Condensed Consolidated Statements of Operations
(In Thousands, Except Share and Per Share Amounts)
(Unaudited)
 
 
Three Months Ended September 30,
 
Nine Months Ended September 30,
 
2012
 
2011
 
2012
 
2011
Revenues
 
 
 
 
 
 
 
Product sales
$
4,728

 
$
31,162

 
$
46,615

 
$
92,998

Grants and collaborations revenue
14,380

 
5,114

 
21,225

 
12,454

Total revenues
19,108

 
36,276

 
67,840

 
105,452

Costs and operating expenses
 
 
 
 
 
 
 
Cost of products sold
4,444

 
35,729

 
71,891

 
99,247

Loss on purchase commitments and write off of production assets
1,438

 

 
38,090

 

Research and development
15,736

 
23,441

 
55,580

 
66,622

Sales, general and administrative
17,355

 
21,174

 
61,301

 
59,401

Total costs and operating expenses
38,973

 
80,344

 
226,862

 
225,270

Loss from operations
(19,865
)
 
(44,068
)
 
(159,022
)
 
(119,818
)
Other income (expense):
 
 
 
 
 
 
 
Interest income
297

 
609

 
1,406

 
1,250

Interest expense
(1,224
)
 
(291
)
 
(3,538
)
 
(1,172
)
Other income (expense), net
664

 
310

 
(512
)
 
160

Total other income (expense)
(263
)
 
628

 
(2,644
)
 
238

Loss before income taxes
(20,128
)
 
(43,440
)
 
(161,666
)
 
(119,580
)
Provision for income taxes
(260
)
 
(474
)
 
(753
)
 
(299
)
Net loss
$
(20,388
)
 
$
(43,914
)
 
$
(162,419
)
 
$
(119,879
)
Net loss attributable to noncontrolling interest
95

 
224

 
772

 
437

Net loss attributable to Amyris, Inc. common stockholders
$
(20,293
)

$
(43,690
)
 
$
(161,647
)
 
$
(119,442
)
Net loss per share attributable to common stockholders, basic and diluted
$
(0.34
)
 
$
(0.97
)
 
$
(2.91
)
 
$
(2.68
)
Weighted-average shares of common stock outstanding used in computing net loss per share of common stock, basic and diluted
58,964,226

 
45,031,613

 
55,552,949

 
44,507,686


See the accompanying notes to the unaudited condensed consolidated financial statements.


2



Amyris, Inc.
Condensed Consolidated Statements of Comprehensive Loss
(In Thousands)
(Unaudited)


 
Three Months Ended
September 30,
 
Nine Months Ended
 September 30,
 
2012
 
2011
 
2012
 
2011
Comprehensive loss:
 
 
 
 
 
 
 
Net loss
$
(20,388
)
 
$
(43,914
)
 
$
(162,419
)
 
$
(119,879
)
Change in unrealized loss on investments

 

 

 
(5
)
Foreign currency translation adjustment, net of tax
(410
)
 
(10,642
)
 
(6,346
)
 
(8,318
)
Total comprehensive loss
(20,798
)
 
(54,556
)
 
(168,765
)
 
(128,202
)
Loss attributable to noncontrolling interest
95

 
224

 
772

 
437

Foreign currency translation adjustment attributable to noncontrolling interest
(41
)
 

 
(209
)
 

Comprehensive loss attributable to Amyris, Inc.
$
(20,744
)
 
$
(54,332
)
 
$
(168,202
)
 
$
(127,765
)

See the accompanying notes to the unaudited condensed consolidated financial statements.


3



Amyris, Inc.
Condensed Consolidated Statements of Stockholders' Equity
(Unaudited)


 
 
Common Stock
 
Additional
Paid-in
Capital
 
Accumulated
Deficit
 
Accumulated
Other
Comprehensive
Income (Loss)
 
Noncontrolling
Interest
 
Total
Equity
(In Thousands, Except Share and Per Share Amounts)
Shares
 
Amount
 
December 31, 2011
 
45,933,138

 
$
5

 
$
548,159

 
$
(381,188
)
 
$
(5,924
)
 
$
(240
)
 
$
160,812

Issuance of common stock related to employee stock purchase plan and exercise of stock options
 
1,306,430

 

 
1,313

 

 

 

 
1,313

Issuance of common stock in a private placement, net of issuance cost of $334
 
11,896,425

 
1

 
62,489

 

 

 

 
62,490

Restricted stock units settlement, net of tax withholdings
 
299,584

 

 
(588
)
 

 

 

 
(588
)
Repurchase of common stock
 
(53
)
 

 

 

 

 

 

Recovery of shares from Draths escrow
 
(5,402
)
 

 

 

 

 

 

Stock-based compensation
 

 

 
21,400

 

 

 

 
21,400

Foreign currency translation adjustment, net of tax
 

 

 

 

 
(6,555
)
 
209

 
(6,346
)
Net loss
 

 

 

 
(161,647
)
 

 
(772
)
 
(162,419
)
September 30, 2012
 
59,430,122

 
$
6

 
$
632,773

 
$
(542,835
)
 
$
(12,479
)
 
$
(803
)
 
$
76,662

See the accompanying notes to the unaudited condensed consolidated financial statements.

4



Amyris, Inc.
Condensed Consolidated Statements of Cash Flows
(In Thousands)
(Unaudited)

 
Nine Months Ended September 30,
 
2012
 
2011
Operating activities
 
 
 
Net loss
$
(162,419
)
 
$
(119,879
)
Adjustments to reconcile net loss to net cash used in operating activities:
 
 
 
Depreciation and amortization
10,686

 
7,728

Loss on disposal of property and equipment
208

 

Stock-based compensation
21,400

 
18,836

Amortization of premium on investments

 
630

Amortization of debt discount
316

 

Provision for doubtful accounts
236

 

Loss on purchase commitments and write off of production assets
38,090

 

Change in fair value of derivative instruments
364

 

Other noncash expenses
108

 
(79
)
Changes in assets and liabilities:
 
 
 
Accounts receivable
2,864

 
234

Inventories, net
612

 
(4,623
)
Prepaid expenses and other assets
10,655

 
(1,134
)
Accounts payable
(11,200
)
 
10,993

Accrued and other liabilities
(29,362
)
 
17,700

Deferred revenue
(1,308
)
 
4,587

Deferred rent
(943
)
 
(761
)
Net cash used in operating activities
(119,693
)
 
(65,768
)
Investing activities
 
 
 
Purchase of short-term investments
(8,240
)
 
(55,286
)
Maturities of short-term investments

 
105,000

Sales of short-term investments
16,449

 
44,826

Change in restricted cash
(954
)
 

Acquisition of cash in noncontrolling interest

 
344

Purchase of property and equipment, net of disposals
(50,344
)
 
(54,416
)
Deposits on property and equipment
(562
)
 
(16,832
)
Net cash provided by (used in) investing activities
(43,651
)
 
23,636

Financing activities
 
 
 
Proceeds from issuance of common stock, net of repurchases
696

 
4,987

Proceeds from issuance of common stock in private placements, net of issuance cost
62,490

 

Principal payments on capital leases
(2,970
)
 
(2,109
)
Proceeds from debt issued
105,624

 
7,622

Principal payments on debt
(52,052
)
 
(3,962
)
Initial public offering costs

 
(497
)
Net cash provided by financing activities
113,788

 
6,041

Effect of exchange rate changes on cash and cash equivalents
(1,774
)
 
(827
)
Net decrease in cash and cash equivalents
(51,330
)
 
(36,918
)
Cash and cash equivalents at beginning of period
95,703

 
143,060

Cash and cash equivalents at end of period
$
44,373

 
$
106,142


5



Amyris, Inc.
Condensed Consolidated Statements of Cash Flows—(Continued)
(In Thousands)
(Unaudited)

 
 
Nine Months Ended September 30,
 
2012
 
2011
Supplemental disclosures of cash flow information:
 
 
 
Cash paid for interest
$
2,831

 
$
1,131

Supplemental disclosures of noncash investing and financing activities:
 
 
 
Acquisitions of assets under accounts payable and accrued liabilities
$
5,672

 
$
7,166

Capitalization of manufacturing equipment under ASC840
$

 
$
7,272

Change in unrealized gain (loss) on foreign currency
$
(5,887
)
 
$
(7,265
)
Issuance of common stock upon exercise of warrants
$

 
$
3,554

Unpaid investment in joint venture
$

 
$
108

Long term deposits used for purchase of property and equipment
$
12,286

 
$

Conversion of other liability to notes payable
$
(23,300
)
 
$

Transfer of fixed assets to current assets
$

 
$
886

Acquisition of net assets in noncontrolling interest
$

 
$
25


See the accompanying notes to the unaudited condensed consolidated financial statements.

6



Amyris, Inc.
Notes to Unaudited Condensed Consolidated Financial Statements
 
1. The Company

Amyris, Inc. (the “Company”) was incorporated in California on July 17, 2003 and reincorporated in Delaware on June 10, 2010 for the purpose of leveraging breakthroughs in synthetic biology to develop and provide renewable compounds for a variety of markets. The Company is currently building and applying its industrial synthetic biology platform to provide alternatives to select petroleum-sourced products used in specialty chemical and transportation fuel markets worldwide. The Company’s first commercialization efforts have been focused on a renewable hydrocarbon molecule called farnesene (Biofene®), which forms the basis for a wide range of products varying from specialty chemical applications to transportation fuels, such as diesel. While the Company’s platform is able to use a wide variety of feedstocks, the Company focused initially on Brazilian sugarcane. The Company has secured access to this and other feedstock to expand its production capacity working with existing sugar and ethanol mill owners to build new, adjacent bolt-on facilities at their existing mills. In addition, the Company has entered into various contract manufacturing agreements to support commercial production. The Company has established two principal operating subsidiaries, Amyris Brasil Ltda. (formerly Amyris Brasil S.A., “Amyris Brasil”) for production in Brazil, and Amyris Fuels, LLC ("Amyris Fuels"). Through the third quarter of 2012, the Company conducted an ethanol and reformulated ethanol-blended gasoline business through Amyris Fuels, but has, as of September 30, 2012 transitioned out of that business.

On September 30, 2010, the Company closed its initial public offering (“IPO”) of 5,300,000 shares of common stock. Upon the closing of the IPO, the Company’s outstanding shares of convertible preferred stock were automatically converted into 31,550,277 shares of common stock, the outstanding convertible preferred stock warrants were automatically converted into common stock warrants to purchase a total of 195,604 shares of common stock, and shares of Amyris Brasil held by third party investors were automatically converted into 861,155 shares of the Company’s common stock.

The Company has incurred significant losses since its inception. As of September 30, 2012 , the Company had an accumulated deficit of $542.8 million and management believes that it will continue to incur losses and net cash outflows for the foreseeable future.
The Company's strategy is to focus on direct commercialization of higher-value, lower-volume markets while moving lower-margin, higher-volume commodity products into joint venture arrangements with established industry partners. To commercialize its products, the Company must be successful in using its technology to manufacture its products at commercial scale and on an economically viable basis. The Company is building its experience producing renewable products at commercial scale. The Company's prospects are subject to risks, expenses and uncertainties frequently encountered by companies in this stage of development. These risks include, but are not limited to, the Company's ability to finance its operations, its ability to achieve substantially higher production efficiencies than it has to date, timely completion of the construction and the commencement of operations at its production facilities, and its ability to secure additional collaborations and establish joint ventures on acceptable terms.

The Company expects to fund its operations for the foreseeable future with cash and investments currently on hand, with cash inflows from collaboration and grant funding, cash contributions from product sales, and with new debt and equity financing . In February 2012, the Company completed a private placement of 10.2 million shares of common stock for total proceeds of $58.7 million and raised $25.0 million through convertible promissory notes. In May 2012, the Company completed a private placement of 1.7 million shares of common stock for aggregate proceeds of $4.1 million . In July 2012, the Company completed a sale of a convertible promissory note for cash proceeds of $15.0 million and in September 2012, the Company completed a sale of an additional convertible promissory note for additional cash proceeds of $15.0 million . These notes issued in the third quarter of 2012 used the same conversion price and included the same covenants that were used in the notes issued in February 2012.

The Company's anticipated working capital needs and its planned operating and capital expenditures for the remainder of 2012 and for 2013 will require significant inflows of cash from collaboration partners, as well as funding from equity or debt offerings, credit facilities or loans, or combinations of these sources. Specifically, the Company will need to raise cash in the fourth quarter in order to fund its operations beyond the fourth quarter of 2012. To the extent that additional capital is raised through the sale of equity or convertible debt securities, the issuance of such securities could result in ownership dilution to existing stockholders and the Company may be subject to restrictive covenants that limit the Company's ability to conduct its business.

Beginning in March 2012, the Company initiated a plan to shift a portion of its production capacity from contract manufacturing facilities to a Company-owned plant that is currently under construction. As a result, the Company evaluated its contract manufacturing agreements and recorded a loss of $31.2 million related to the write-off of $10.0 million in facility

7



modification costs and recognition of $21.2 million of fixed purchase commitments in the three months ended March 31, 2012. The Company recognized an additional charge of $1.4 million associated with loss on fixed purchase commitments in the three months ended September 30, 2012. The Company computed the loss on facility modification costs and fixed purchase commitments using the same lower of cost or market approach that is used to value inventory. The computation of the loss on firm purchase commitments is subject to several estimates, including the cost to complete and the ultimate selling price of any Company products manufactured at the relevant production facilities, and is therefore inherently uncertain. The Company also recorded losses on write off of production assets of $5.5 million related to Amyris-owned equipment at contract manufacturing facilities in the three months ended March 31, 2012.

Nearly all of the Company's revenues to date have come from the sale of ethanol and reformulated ethanol-blended gasoline with substantially all of the remaining revenues coming from collaborations and government grants. Effective in the third quarter of 2012, the Company transitioned out of the ethanol and reformulated ethanol-blended gasoline business, which will result in the loss of all future revenue from that business. The Company does not expect to be able to replace much of the revenue lost in the near term as a result of this transition, particularly in 2012 and 2013 while it continues its efforts to establish a renewable products business.

Meeting the Company's anticipated working capital needs and funding its strategic plans for the remainder of 2012 and for 2013 will depend on its ability to identify and secure substantial additional sources of funding beyond those that it has currently identified. Furthermore, some of its anticipated financing sources are subject to risk that it may not meet milestones, or are not yet subject to definitive agreements or funding commitments. Failure to secure such funding in a timely manner, either in the short or long term, the Company may be forced to curtail its operations, which could include reductions or delays of its planned capital expenditures or scaling back its operations. If it is forced to curtail its operations, it may be unable to proceed with construction of certain planned production facilities, including its planned large-scale production plants at Usina São Martinho and Paraíso Bioenergia, enter into definitive agreements for supply of feedstock and associated production arrangements that are currently subject to letters of intent, commercialize its products within the timeline it expects, or otherwise continue its business as currently contemplated.

2. Summary of Significant Accounting Policies

Basis of Presentation

The accompanying interim condensed consolidated financial statements have been prepared in accordance with the accounting principles generally accepted in the United States of America (“GAAP”) and with the instructions for Form 10-Q and Regulations S-X statements. Accordingly, they do not include all of the information and notes required for complete financial statements. These interim condensed consolidated financial statements should be read in conjunction with the consolidated financial statements and notes thereto contained in the Company’s Form 10-K filed with the Securities and Exchange Commission (“SEC”) on February 28, 2012. The unaudited condensed consolidated financial statements include the accounts of the Company and its consolidated subsidiaries. All intercompany accounts and transactions have been eliminated in consolidation.

Principles of Consolidations

The Company has interests in joint venture entities that are variable interest entities (“VIEs”). Determining whether to consolidate a variable interest entity may require judgment in assessing (i) whether an entity is a VIE and (ii) if the Company is the entity’s primary beneficiary and thus required to consolidate the entity. To determine if the Company is the primary beneficiary of a VIE, the Company evaluates whether it has (i) the power to direct the activities that most significantly impact the VIE’s economic performance and (ii) the obligation to absorb losses or the right to receive benefits of the VIE that could potentially be significant to the VIE. The Company’s evaluation includes identification of significant activities and an assessment of its ability to direct those activities based on governance provisions and arrangements to provide or receive product and process technology, product supply, operations services, equity funding and financing and other applicable agreements and circumstances. The Company’s assessment of whether it is the primary beneficiary of its VIEs requires significant assumptions and judgment.

The unaudited condensed consolidated financial statements of the Company include the accounts of Amyris, Inc., its subsidiaries and two consolidated VIEs with respect to which the Company is considered the primary beneficiary, after elimination of intercompany accounts and transactions. Disclosure regarding the Company’s participation in the VIEs is included in Note 8.

Use of Estimates

In preparing the unaudited condensed consolidated financial statements, management must make estimates and assumptions that affect the reported amounts of assets and liabilities and disclosure of contingent assets and liabilities as of the date of the

8



unaudited condensed consolidated financial statements and the reported amounts of revenue and expenses during the reporting period. Actual results could differ from those estimates.

Unaudited Interim Financial Information

The accompanying interim condensed consolidated financial statements and related disclosures are unaudited, have been prepared on the same basis as the annual consolidated financial statements and, in the opinion of management, reflect all adjustments, which include only normal recurring adjustments, necessary for a fair statement of the results of operations for the periods presented. The condensed consolidated results of operations for any interim period are not necessarily indicative of the results to be expected for the full year or for any other future year or interim period.

Concentration of Credit Risk

Financial instruments that potentially subject the Company to a concentration of credit risk consist primarily of cash and cash equivalents and accounts receivable. The Company places its cash equivalents and investments with high credit quality financial institutions and, by policy, limits the amount of credit exposure with any one financial institution. Deposits held with banks may exceed the amount of insurance provided on such deposits. The Company has not experienced any losses on its deposits of cash and cash equivalents and short-term investments.

The Company performs ongoing credit evaluation of its customers, does not require collateral, and maintains allowances for potential credit losses on customer accounts when deemed necessary.

Customers representing 10% or greater of accounts receivable were as follows:
 
Customers
September 30, 2012
 
December 31, 2011
Customer A
*

 
20
%
Customer B
38
%
 
**

Customer C
13
%
 
**

Customer D
11
%
 
**

Customer E
**

 
10
%
Customer F
26
%
 
**

 
* No outstanding balance
** Less than 10%

Customers representing 10% or greater of revenues were as follows:
 
Three Months Ended September 30,
 
Nine Months Ended
 September 30,
Customers
2012
 
2011
 
2012
 
2011
Customer A
*

 
17
%
 
14
%
 
**

Customer C
14
%
 
**

 
**

 
**

Customer G
**

 
**

 
**

 
17
%
Customer H
51
%
 
*

 
14
%
 
**

Customer I
*

 
12
%
 
**

 
**


 * Not a current customer
** Less than 10%


Fair Value of Financial Instruments

The Company measures certain financial assets and liabilities at fair value based on the exchange price that would be received for an asset or paid to transfer a liability (an exit price) in the principal or most advantageous market for the asset or liability in an orderly transaction between market participants. Where available, fair value is based on or derived from observable market

9



prices or other observable inputs. Where observable prices or inputs are not available, valuation models are applied. These valuation techniques involve some level of management estimation and judgment, the degree of which is dependent on the price transparency for the instruments or market and the instruments’ complexity.

The carrying amounts of certain financial instruments, such as cash equivalents, accounts receivable, accounts payable and accrued liabilities, approximate fair value due to their relatively short maturities, and low market interest rates if applicable. The fair values of the notes payable, loan payable, convertible notes and credit facility are based on the present value of expected future cash flows and assumptions about current interest rates and the creditworthiness of the Company.

The Company estimates the fair value of its embedded derivative related to Total convertible notes using a Black-Scholes valuation model that combines expected cash outflows with market-based assumptions regarding risk-adjusted yields, stock price volatility, probability of a change of control and the trading information of the Company's common stock into which the notes are convertible. The Company will continue to mark the bifurcated compound derivative to market due to the conversion price not being indexed to the Company's own stock because of the feature requiring the Company to redeem foregone interest upon conversion by the holder. The change in the fair value of the bifurcated compound derivative is primarily related to the change in price of the underlying common stock and is reflected in the Company's consolidated statements of operations as “other income (expense)”.

Cash and Cash Equivalents

All highly liquid investments purchased with an original maturity date of 90 days or less at the date of purchase are considered to be cash equivalents. Cash and cash equivalents consist of money market funds, certificates of deposit, commercial paper, U.S. Government agency securities and various deposit accounts.

Accounts Receivable

The Company maintains an allowance for doubtful accounts receivable for estimated losses resulting from the inability of its customers to make required payments. The Company determines this allowance based on specific doubtful account identification and management judgment on estimated exposure. The Company writes off accounts receivable against the allowance when it determines a balance is uncollectible and no longer actively pursues collection of the receivable. 

Investments

Investments with original maturities greater than 90 days that mature less than one year from the consolidated balance sheet date are classified as short-term investments. The Company classifies investments as short-term or long-term based upon whether such assets are reasonably expected to be realized in cash or sold or consumed during the normal cycle of business. The Company invests its excess cash balances primarily in certificates of deposit, short-term investment grade commercial paper and corporate bonds, and U.S. Government agency securities and notes. Certificates of deposits that have maturities greater than 90 days that mature less than one year from the consolidated balance sheet date are classified as short term investments. The Company classifies all of its investments as available-for-sale and records such assets at estimated fair value in the consolidated balance sheets, with unrealized gains and losses, if any, reported as a component of accumulated other comprehensive income (loss) in stockholders’ equity. Debt securities are adjusted for amortization of premiums and accretion of discounts and such amortization and accretion are reported as a component of interest income. Realized gains and losses and declines in value that are considered to be other than temporary are recognized in the statements of operations. The cost of securities sold is determined on the specific identification method. There were no significant realized gains or losses from sales of debt securities during the nine months ended September 30, 2012 and 2011 . As of September 30, 2012 and December 31, 2011 , the Company did not have any other-than-temporary declines in the fair value of its debt securities.

Restricted Cash

Cash accounts that are restricted to withdrawal or usage are presented as restricted cash. As of September 30, 2012 and December 31, 2011 , the Company had $954,000 and zero , respectively, of restricted cash held by a bank in a certificate of deposit as collateral under a facility lease.

Inventories

Inventories, which consist of farnesene-derived products, as well as ethanol and reformulated ethanol-blended gasoline, are stated at the lower of cost or market and categorized as finished goods, work-in-process or raw material inventories. In the quarter ended September 30, 2012 the Company sold its remaining inventory of ethanol and reformulated ethanol-blended gasoline as it

10



transitioned out of this business. The Company evaluates the recoverability of its inventories based on assumptions about expected demand and net realizable value. If the Company determines that the cost of inventories exceeds its estimated net realizable value, the Company records a write-down equal to the difference between the cost of inventories and the estimated net realizable value. If actual net realizable values are less favorable than those projected by management, additional inventory write-downs may be required that could negatively impact the Company's operating results. If actual net realizable values are more favorable, the Company may have favorable operating results when products that have been previously written down are sold in the normal course of business. The Company also evaluates the terms of its agreements with its suppliers and establishes accruals for estimated losses on adverse purchase commitments as necessary, applying the same lower of cost or market approach that is used to value inventory. Cost is computed on a first-in, first-out basis. Inventory costs include transportation costs incurred in bringing the inventory to its existing location.

Derivative Instruments

The Company makes limited use of derivative instruments, which includes currency interest rate swap agreements to manage the Company's exposure to foreign currency exchange rate fluctuations and interest rate fluctuations related to the Company's Banco Pine S.A. loan (discussed below under Note 6). Through the third quarter of 2012, the Company held futures positions on the New York Mercantile Exchange and the CME/Chicago Board of Trade to mitigate the risks related to the price volatility of ethanol and reformulated ethanol-blended gasoline but as of September 30, 2012 the Company has transitioned out of that business and no longer held such derivative instruments. The Company does not engage in speculative derivative activities, and the purpose of its activity in derivative commodity instruments is to manage the financial risk posed by physical transactions and inventory. Changes in the fair value of the derivative contracts are recognized currently in the condensed consolidated statements of operations.

Asset Retirement Obligations

The fair value of an asset retirement obligation is recognized in the period in which it is incurred if a reasonable estimate of fair value can be made. In addition, asset retirement cost is added to the carrying amount of the associated asset and this additional carrying amount is amortized over the life of the asset. The Company’s asset retirement obligations are associated with its commitment to return property subject to an operating lease in Brazil to its original condition upon lease termination.
 
As of September 30, 2012 and December 31, 2011 , the Company had asset retirement obligations of $1.1 million and $1.1 million , respectively. The related leasehold improvements are being amortized to depreciation expense over the term of the lease or the useful life of the assets, whichever is shorter. Related amortization expense was $59,000 and $4,000 for the three months ended September 30, 2012 and 2011 , respectively, and $188,000 and $136,000 for nine months ended September 30, 2012 and 2011 , respectively.

The change in the asset retirement obligation is summarized below (in thousands):
 
Balance at December 31, 2011
$
1,129

Additions

Foreign currency impacts and other adjustments
(91
)
Accretion expenses recorded during the period
91

Balance at September 30, 2012
$
1,129


Property and Equipment, net

Property and equipment, net is stated at cost less accumulated depreciation and amortization. Depreciation and amortization is computed using the straight-line method over the estimated useful lives of the related assets. Maintenance and repairs are charged to expense as incurred, and improvements and betterments are capitalized. When assets are retired or otherwise disposed of, the cost and accumulated depreciation are removed from the balance sheet and any resulting gain or loss is reflected in operations in the period realized.

Depreciation and amortization periods for the Company’s property and equipment are as follows:


11



Machinery and equipment
7-15 years
Computers and software
3-5 years
Furniture and office equipment
5 years
Vehicles
5 years

Leasehold improvements are amortized on a straight-line basis over the terms of the lease, or the useful life of the assets, whichever is shorter.

Computers and software includes internal-use software that is acquired, internally developed or modified to meet the Company’s internal needs. Amortization commences when the software is ready for its intended use and the amortization period is the estimated useful life of the software, generally three to five years. Capitalized costs primarily include contract labor and payroll costs of the individuals dedicated to the development of internal-use software. Capitalized software additions totaled approximately $521,000 and $1.2 million for the nine months ended September 30, 2012 and 2011 , respectively, related to software development costs pertaining to the installation of a new financial reporting system. For the nine months ended September 30, 2012 and 2011 , $449,000 and $308,000 , respectively, of amortization expense was recorded and as of September 30, 2012 and December 31, 2011 , the total unamortized cost of capitalized software was $2.9 million and $2.8 million , respectively.

Impairment of Long-Lived Assets

Long-lived assets to be held and used are reviewed for impairment whenever events or changes in circumstances indicate that the carrying amount of an asset may not be recoverable or the estimated useful life is no longer appropriate. If indicators of impairment exist and the undiscounted projected cash flows associated with such assets are less than the carrying amount of the asset, an impairment loss is recorded to write the assets down to their estimated fair values. Fair value is estimated based on discounted future cash flows. The Company recorded losses on write off of production assets of $5.5 million and zero during the nine months ended September 30, 2012 and 2011 , respectively.

Goodwill and Intangible Assets  

Goodwill represents the excess of the cost over the fair value of net assets acquired from our business combinations. Intangible assets are comprised primarily of in-process research and development ("IPR&D"). The Company makes significant judgments in relation to the valuation of goodwill and intangible assets resulting from business combinations.

 
There are several methods that can be used to determine the estimated fair value of the IPR&D acquired in a business combination. The Company utilized the "income method," which applies a probability weighting that considers the risk of development and commercialization, to the estimated future net cash flows that are derived from projected sales revenues and estimated costs. These projections are based on factors such as relevant market size, pricing of similar products, and expected industry trends. The estimated future net cash flows are then discounted to the present value using an appropriate discount rate. These assets are treated as indefinite-lived intangible assets until completion or abandonment of the projects, at which time the assets will be amortized over the remaining useful life or written off, as appropriate.

Goodwill and intangible assets with indefinite lives are assessed for impairment using fair value measurement techniques on an annual basis or more frequently if facts and circumstance warrant such a review. When required, a comparison of fair value to the carrying amount of assets is performed to determine the amount of any impairment.

 
The Company evaluates its intangible assets with finite lives for indications of impairment whenever events or changes in circumstances indicate that the carrying value may not be recoverable. Intangible assets consist of purchased licenses and permits and are amortized on a straight-line basis over their estimated useful lives. Factors that could trigger an impairment review include significant under-performance relative to historical or projected future operating results, significant changes in the manner of use of the acquired assets or the strategy for overall business or significant negative industry or economic trends. If this evaluation indicates that the value of the intangible asset may be impaired, the Company makes an assessment of the recoverability of the net carrying value of the asset over its remaining useful life. If this assessment indicates that the intangible asset is not recoverable, based on the estimated undiscounted future cash flows of the technology over the remaining amortization period, the Company will reduce the net carrying value of the related intangible asset to fair value and may adjust the remaining amortization period. Any such impairment charge could be significant and could have a material adverse effect on the Company's reported financial results. The Company has not recognized any impairment charges on intangible assets through September 30, 2012 .

In-Process Research and Development

12




 
During 2011, the Company recorded IPR&D of $8.6 million related to the acquisition of Draths Corporation ("Draths"). Amounts recorded as IPR&D will begin being amortized upon first sales of the product over the estimated useful life of the technology. In accordance with authoritative accounting guidance, since the technology has not yet been proven, the amortization of the acquired IPR&D has not begun. The Company estimates that it could take up to three years before it will have viable products resulting from the acquired technology.

Noncontrolling Interest

Changes in noncontrolling interest ownership that do not result in a change of control and where there is a difference between fair value and carrying value are accounted for as equity transactions.

On April 14, 2010, the Company entered into a joint venture with Usina São Martinho. The carrying value of the noncontrolling interest from this joint venture is recorded in the equity section of the consolidated balance sheets (see Note 8).

On January 3, 2011, the Company entered into a production service agreement with Glycotech, Inc. ("Glycotech"). The Company has determined that the arrangement with Glycotech qualifies as a VIE. The Company determined that it is the primary beneficiary. The carrying value of the noncontrolling interest from this VIE is recorded in the equity section of the consolidated balance sheets (see Note 8).

Revenue Recognition

The Company recognizes revenue from the sale of farnesene-derived products, delivery of research and development services, and from governmental grants. Through the third quarter of 2012, the Company also sold ethanol and reformulated ethanol-blended gasoline under short-term agreements at prevailing market prices but as of September 30, 2012 the Company has transitioned out of that business. Revenue is recognized when all of the following criteria are met: persuasive evidence of an arrangement exists, delivery has occurred or services have been rendered, the fee is fixed or determinable, and collectibility is reasonably assured.

If sales arrangements contain multiple elements, the Company evaluates whether the components of each arrangement represent separate units of accounting. To date the Company has determined that all revenue arrangements should be accounted for as a single unit of accounting.

Product Sales

Beginning in the second quarter of 2011, the Company began to sell farnesene-derived products, which were produced by contracted third parties. Through the third quarter of 2012, the Company also sold ethanol and reformulated ethanol-blended gasoline under short-term agreements at prevailing market prices but as of September 30, 2012 the Company has transitioned out of that business. Ethanol and reformulated ethanol-blended gasoline sales consisted of sales to customers through purchases from third-party suppliers in which the Company took physical control of the ethanol and reformulated ethanol-blended gasoline and accepted risk of loss. The Company's renewable product sales do not include rights of return. Returns are only accepted if the product does not meet product specifications and such nonconformity is communicated to the Company within a set number of days of delivery. Commencing April 1, 2012, the Company began offering a two year standard warranty provision for squalane products sold after March 31, 2012 if the products do not meet Company-established criteria as set forth in the Company's trade terms. The Company based its return reserve on a combination of historical rate of return for the Company's squalane products and historical returns for companies in the cosmetics industry since the Company did not have a full two years of historical return data. Revenues are recognized, net of discounts and allowances, once passage of title and risk of loss has occurred and contractually specified acceptance criteria have been met, provided all other revenue recognition criteria have also been met.

Grants and Collaborative Revenue

Revenue from collaborative research services is recognized as the services are performed consistent with the performance requirements of the contract. In cases where the planned levels of research services fluctuate over the research term, the Company recognizes revenue using the proportionate performance method based upon actual efforts to date relative to the amount of expected effort to be incurred by the Company. When up-front payments are received and the planned levels of research services do not fluctuate over the research term, revenue is recorded on a ratable basis over the arrangement term, up to the amount of cash received. When up-front payments are received and the planned levels of research services fluctuate over the research term, revenue is recorded using the proportionate performance method, up to the amount of cash received. Where arrangements include milestones

13



that are determined to be substantive and at risk at the inception of the arrangement, revenue is recognized upon achievement of the milestone and is limited to those amounts whereby collectibility is reasonably assured.

Government grants are agreements that generally provide cost reimbursement for certain types of expenditures in return for research and development activities over a contractually defined period. Revenues from government grants are recognized in the period during which the related costs are incurred, provided that the conditions under which the government grants were provided have been met and only perfunctory obligations are outstanding. Under the Defense Advanced Research Projects Agency (DARPA) contract signed in June 2012, the Company will receive funding based on achievement of program milestones. Accordingly the Company will recognize revenue using the proportionate performance method based upon actual efforts to date relative to the amount of expected effort to be incurred, up to the amount of verified payable milestones.

Cost of Products Sold

Cost of products sold consists primarily of cost of purchased ethanol and reformulated ethanol-blended gasoline, terminal fees paid for storage and handling, transportation costs between terminals and changes in the fair value of derivative commodity instruments. Starting in the second quarter of 2011, cost of products sold also includes production costs of farnesene-derived products, which include cost of raw materials, amounts paid to contract manufacturers and period costs including inventory write-downs resulting from applying lower-of-cost-or-market inventory rules. Cost of farnesene-derived products sold also includes certain costs related to the scale-up in production of such products.

Shipping and handling costs charged to customers are recorded as revenues. Shipping costs are included in cost of products sold. Such charges were not significant in any of the periods presented.

Costs of Start-Up Activities

Start-up activities are defined as those one-time activities related to opening a new facility, introducing a new product or service, conducting business in a new territory, conducting business with a new class of customer or beneficiary, initiating a new process in an existing facility, commencing some new operation or activities related to organizing a new entity. All the costs associated with start-up activities related to a potential facility are expensed and recorded within selling, general and administrative expenses until the facility is considered viable by management, at which time costs would be considered for capitalization based on authoritative accounting literature.

Research and Development

Research and development costs are expensed as incurred and include costs associated with research performed pursuant to collaborative agreements and government grants. Research and development costs consist of direct and indirect internal costs related to specific projects as well as fees paid to others that conduct certain research activities on the Company’s behalf.
 
Income Taxes

The Company accounts for income taxes under the asset and liability method, which requires, among other things, that deferred income taxes be provided for temporary differences between the tax basis of the Company’s assets and liabilities and their financial statement reported amounts. In addition, deferred tax assets are recorded for the future benefit of utilizing net operating losses and research and development credit carryforwards. A valuation allowance is provided against deferred tax assets unless it is more likely than not that they will be realized.

The Company recognizes and measures uncertain tax positions in accordance with Income Taxes subtopic 05-6 of ASC 740, which prescribes a recognition threshold and measurement process for recording uncertain tax positions taken, or expected to be taken in a tax return, in the consolidated financial statements. Additionally, the guidance also prescribes treatment for the derecognition, classification, accounting in interim periods and disclosure requirements for uncertain tax positions. The Company accrues for the estimated amount of taxes for uncertain tax positions if it is more likely than not that the Company would be required to pay such additional taxes. An uncertain tax position will not be recognized if it has a less than 50% likelihood of being sustained.

Currency Translation

The Brazilian real is the functional currency of the Company’s wholly-owned subsidiary in Brazil and also of the Company’s joint venture with Usina São Martinho. Accordingly, asset and liability accounts of those operations are translated into United States dollars using the current exchange rate in effect at the balance sheet date and equity accounts are translated into United

14



States dollars using historical rates. The revenues and expenses are translated using the exchange rates in effect when the transactions occur. Gains and losses from foreign currency translation adjustments are included as a component of accumulated other comprehensive income (loss) in the consolidated balance sheets.

Stock-Based Compensation

The Company accounts for stock-based compensation arrangements with employees using a fair value method which requires the recognition of compensation expense for costs related to all stock-based payments including stock options. The fair value method requires the Company to estimate the fair value of stock-based payment awards on the date of grant using an option pricing model. The Company uses the Black-Scholes pricing model to estimate the fair value of options granted, which is expensed on a straight-line basis over the vesting period. The Company accounts for restricted stock unit awards issued to employees based on the fair market value of the Company’s common stock.

The Company accounts for stock options issued to nonemployees based on the estimated fair value of the awards using the Black-Scholes option pricing model. The Company accounts for restricted stock units issued to nonemployees based on the fair market value of the Company’s common stock. The measurement of stock-based compensation is subject to periodic adjustments as the underlying equity instruments vest, and the resulting change in value, if any, is recognized in the Company’s consolidated statements of operations during the period the related services are rendered.

Comprehensive Income (Loss)

Comprehensive income (loss) represents all changes in stockholders’ equity except those resulting from investments or contributions by stockholders. The Company’s unrealized gains and losses on available-for-sale securities and foreign currency translation adjustments represent the components of comprehensive income (loss) excluded from the Company’s net loss and have been disclosed in the condensed consolidated statements of comprehensive loss for all periods presented.

The components of accumulated other comprehensive loss are as follows (in thousands):
 
 
September 30, 2012
 
December 31, 2011
Foreign currency translation adjustment, net of tax
$
(12,479
)
 
$
(5,924
)
Total accumulated other comprehensive loss
$
(12,479
)
 
$
(5,924
)

Net Loss Attributable to Common Stockholders and Net Loss per Share

The Company computes net loss per share in accordance with ASC 260, “Earnings per Share.” Basic net loss per share of common stock is computed by dividing the Company’s net loss attributable to Amyris, Inc. common stockholders by the weighted-average number of shares of common stock outstanding during the period. Diluted net loss per share of common stock is computed by giving effect to all potentially dilutive securities, including stock options, restricted stock units, common stock warrants, using the treasury stock method or the as converted method, as applicable. For all periods presented, basic net loss per share was the same as diluted net loss per share because the inclusion of all potentially dilutive securities outstanding was anti-dilutive. As such, the numerator and the denominator used in computing both basic and diluted net loss are the same for each period presented.

The following table presents the calculation of basic and diluted net loss per share of common stock attributable to Amyris, Inc. common stockholders (in thousands, except share and per share amounts):
 
 
Three Months Ended September 30,
 
Nine Months Ended
 September 30,
 
2012
 
2011
 
2012
 
2011
Numerator:
 
 
 
 
 
 
 
Net loss attributable to Amyris, Inc. common stockholders
$
(20,293
)
 
$
(43,690
)
 
$
(161,647
)
 
$
(119,442
)
Denominator:
 
 
 
 
 
 
 
Weighted-average shares of common stock outstanding used in computing net loss per share of common stock, basic and diluted
58,964,226

 
45,031,613

 
55,552,949

 
44,507,686

Net loss per share attributable to common stockholders, basic and diluted
$
(0.34
)
 
$
(0.97
)
 
$
(2.91
)
 
$
(2.68
)


15



The following outstanding shares of potentially dilutive securities were excluded from the computation of diluted net loss per share of common stock for the periods presented because including them would have been antidilutive:
 
 
Nine Months Ended September 30,
 
2012
 
2011
Period-end stock options to purchase common stock
8,345,400

 
8,353,279

Convertible promissory notes
11,077,785

 

Period-end common stock subject to repurchase
301

 
10,335

Period-end common stock warrants
21,087

 
5,136

Period-end restricted stock units
1,712,899

 
375,189

Total
21,157,472

 
8,743,939


 
Recent Accounting Pronouncements

In May 2011, the FASB issued an amendment to an accounting standard related to fair value measurement. This amendment is intended to result in convergence between U.S. GAAP and International Financial Reporting Standards (“IFRS”) requirements for measurement of and disclosures about fair value. This guidance clarifies the application of existing fair value measurements and disclosures, and changes certain principles or requirements for fair value measurements and disclosures. The amended guidance is effective for interim and annual periods beginning after December 15, 2011. The adoption of this amended guidance required expanded disclosure in the Company's consolidated financial statements but did not impact financial results.

In June 2011, the FASB issued an amendment to an accounting standard related to the presentation of the Statement of Comprehensive Income. This amendment requires companies to present the components of net income and other comprehensive income either as one continuous statement or as two consecutive statements. It eliminates the option to present components of other comprehensive income as part of the statement of changes in stockholders' equity. The amended guidance is effective for interim and annual periods beginning after December 15, 2011 with full retrospective application required. Early adoption is permitted. The Company chose early adoption of this guidance effective its year ended December 31, 2011 through a separate presentation of its Consolidated Statement of Comprehensive Income for the years ended December 31, 2011, 2010 and 2009. The adoption of this amended guidance changed the financial statement presentation and required expanded disclosures in the Company's consolidated financial statements, but did not impact financial results.

In September 2011, the FASB approved a revised accounting standard update intended to simplify how an entity tests goodwill for impairment. The amendment will allow an entity to first assess qualitative factors to determine whether it is necessary to perform the two-step quantitative goodwill impairment test. An entity no longer will be required to calculate the fair value of a reporting unit unless the entity determines, based on a qualitative assessment, that it is more likely than not that its fair value is less than its carrying amount. This accounting standard update is effective for annual and interim goodwill impairment tests performed for fiscal years beginning after December 15, 2011. The adoption of this amended guidance did not have any impact on the Company's financial results.

In December 2011, the International Accounting Standards Board ("IASB") and the FASB issued common disclosure requirements that are intended to enhance comparability between financial statements prepared on the basis of U.S. GAAP and those prepared in accordance with IFRS. This new guidance affects all entities with financial instruments or derivatives that are either presented on a net basis on the balance sheet or subject to an enforceable master netting arrangement or similar arrangement. While this guidance does not change existing offsetting criteria in U.S. GAAP or the permitted balance sheet presentation for items meeting the criteria, it requires an entity to disclose both net and gross information about assets and liabilities that have been offset and the related arrangements. Required disclosures under this new guidance should be provided retrospectively for all comparative periods presented. This new guidance is effective for fiscal years beginning on or after January 1, 2013, and interim periods within those years, which would be the Company's first quarter of fiscal 2013. The Company does not expect that the adoption of this new guidance will have an impact on its financial position, results of operations or cash flows as it is disclosure only in nature.

In July 2012, the FASB issued an amended accounting standard update to simplify how entities test indefinite-lived intangible assets for impairment which improve consistency in impairment testing requirements among long-lived asset categories. The amended guidance permits an assessment of qualitative factors to determine whether it is more likely than not that the fair value of an indefinite-lived intangible asset is less than its carrying value. For assets in which this assessment concludes it is more likely

16



than not that the fair value is more than its carrying value, then the amended guidance eliminates the requirement to perform quantitative impairment testing as outlined in the previously issued standards. The amended guidance is effective for fiscal years beginning after September 15, 2012; however, early adoption is permitted. The Company does not expect this amended guidance to have an impact on the Company's financial results.


3. Fair Value Measurements

The inputs to the valuation techniques used to measure fair value are classified into the following categories:

Level 1: Quoted market prices in active markets for identical assets or liabilities.

Level 2: Observable market-based inputs or unobservable inputs that are corroborated by market data.

Level 3: Unobservable inputs that are not corroborated by market data.


As of September 30, 2012 , the Company’s financial assets and financial liabilities are presented below at fair value and were classified within the fair value hierarchy as follows (in thousands):
 
Level 1
 
Level 2
 
Level 3
 
Balance as of September 30, 2012
Financial Assets
 
 
 
 
 
 
 
Money market funds
$
20,718

 
$

 
$

 
$
20,718

Certificates of deposit
5,823

 

 

 
5,823

Derivative asset

 

 

 

Total financial assets
$
26,541

 
$

 
$

 
$
26,541

Financial Liabilities
 
 
 
 
 
 
 
Notes payable
$

 
$
1,762

 
$

 
$
1,762

Loans payable

 
21,133

 

 
21,133

Credit facilities

 
9,777

 

 
9,777

Convertible notes

 

 
63,278

 
63,278

Compound embedded derivative liability

 

 
10,263

 
10,263

Currency interest rate swap derivative liability

 
1,126

 

 
1,126

Total financial liabilities
$

 
$
33,798

 
$
73,541

 
$
107,339


The Company’s assessment of the significance of a particular input to the fair value measurement in its entirety requires management to make judgments and consider factors specific to the asset or liability. The fair values of money market funds are based on fair values of identical assets. The fair values of the notes payable, loan payable, convertible notes, credit facility and currency interest rate swaps are based on the present value of expected future cash flows and assumptions about current interest rates and the creditworthiness of the Company. Market risk associated with our fixed and variable rate long-term debt relates to the potential reduction in fair value and negative impact to future earnings, respectively, from an increase in interest rates.

The following table provides a reconciliation of the beginning and ending balances for the compound embedded derivative liability measured at fair value using significant unobservable inputs (Level 3) (in thousands):

 
Compound Embedded Derivative Liability
Balance at December 31, 2011
$

    Transfers in to Level 3
11,025

    Total (gain) losses included in other income (expense), net
(762
)
Balance at September 30, 2012
$
10,263



17



The compound embedded derivative liability, which is included in other liabilities, represents the value of the equity conversion option and a "make-whole" provision of outstanding convertible notes issued to Total Gas & Power USA SAS (see Note 6). There is no current observable market for this type of derivative and, as such, the Company determined the value of the embedded derivative using a Black-Scholes valuation model that combines expected cash outflows with market-based assumptions regarding risk-adjusted yields, stock price volatility, probability of a change of control and the trading information of the Company's common stock into which the notes are convertible. The Company will mark the embedded derivative to market due to the conversion price not being indexed to the Company's own stock. Except for the "make-whole interest" provision included in the conversion option, which is only required to be settled in cash upon a change of control, at the noteholder's option, the embedded derivative will be settled in either cash or shares. As of September 30, 2012 , the Company has enough common shares to settle the conversion option in shares.

The Company’s financial assets and financial liabilities as of December 31, 2011 are presented below at fair value and were classified within the fair value hierarchy as follows (in thousands):
 
Level 1
 
Level 2
 
Level 3
 
Balance as of December 31, 2011
Financial Assets
 
 
 
 
 
 
 
Money market funds
$
57,127

 
$

 
$

 
$
57,127

Certificates of Deposit
27,384

 

 

 
27,384

Total financial assets
$
84,511

 
$

 
$

 
$
84,511

Financial Liabilities

 

 

 

Derivative liabilities
$
18

 
$

 
$

 
$
18

Total financial liabilities
$
18

 
$

 
$

 
$
18



Derivative Instruments

The Company’s derivative instruments included Chicago Board of Trade (CBOT) ethanol futures and Reformulated Blendstock for Oxygenate Blending (RBOB) gasoline futures. All derivative commodity instruments were recorded at fair value on the consolidated balance sheets. None of the Company’s derivative instruments were designated as a hedging instrument. Changes in the fair value of these non-designated hedging instruments were recognized in cost of products sold in the condensed consolidated statements of operations.

In June 2012, the Company entered into a loan agreement with Banco Pine S.A. under which the bank provided the Company with a short term loan of R$52.0 million (approximately US$25.6 million based on the exchange rate as of September 30, 2012 ) (the “Bridge Loan”). At the time of the Bridge Loan, the Company also entered into a currency interest rate swap arrangement with Banco Pine with respect to the repayment of R$22.0 million (approximately US$10.8 million based on the exchange rate of as of September 30, 2012 ). The swap arrangement exchanges the principal and interest payments under the Bridge Loan for alternative principal and interest payments that are subject to adjustment based on fluctuations in the foreign exchange rate between the U.S. dollar and Brazilian real. The swap has a fixed interest rate of 3.94% . Changes in the fair value of the swap are recognized in other income (expense) in the condensed consolidated statements of operations.

Derivative instruments measured at fair value as of September 30, 2012 and December 31, 2011 , and their classification on the consolidated balance sheets and consolidated statements of operations, are presented in the following tables (in thousands except contract amounts)

 
Asset/Liability as of
 
September 30, 2012
 
December 31, 2011
Type of Derivative Contract
Quantity of
Short
Contracts
 
Fair Value
 
Quantity of
Short
Contracts
 
Fair Value
Regulated fixed price futures contracts, included as liability in accounts payable
 
$

 
22
 
$
18

Currency interest rate swap, included as net liability in other long term liability
1
 
$

 
 
$

 

18



Type of Derivative Contract
 
Income
Statement Classification
 
Three Months Ended September 30,
 
Nine Months Ended September 30,
 
 
2012
 
2011
 
2012
 
2011
 
 
Gain (Loss) Recognized
 
Gain (Loss) Recognized
Regulated fixed price futures contracts
 
Cost of products sold
 
$
(31
)
 
$
625

 
$
(288
)
 
$
(2,103
)
Currency interest rate swap
 
Other income (expense), net
 
$
82

 
$

 
$
(1,133
)
 
$



4. Balance Sheet Components

Investments

The following table summarizes the Company’s investments as of September 30, 2012 (in thousands):

 
September 30, 2012
 
Amortized
Cost
 
Unrealized Gain
(Loss)
 
Fair Value
Short-Term Investments
 
 
 
 
 
Certificates of Deposit
$
56

 
$

 
$
56

Total short-term investments
$
56

 
$

 
$
56


The following table summarizes the Company’s investments as of December 31, 2011 (in thousands):

 
December 31, 2011
 
Amortized
Cost
 
Unrealized Gain
(Loss)
 
Fair Value
Short-Term Investments
 
 
 
 
 
Certificates of Deposit
$
7,889

 
$

 
$
7,889

Total short-term investments
$
7,889

 
$

 
$
7,889



Inventories, net

Inventories, net, is comprised of the following (in thousands):
 
September 30, 2012
 
December 31, 2011
Raw materials
$
1,805

 
$
2,191

Work-in-process
5,105

 
1,237

Finished goods
1,401

 
5,642

Inventories, net
$
8,311

 
$
9,070


Prepaid and Other Current Assets

Prepaid and other current assets is comprised of the following (in thousands):
 
September 30, 2012
 
December 31, 2011
Advances to contract manufacturers (1)
$
820

 
$
10,748

Manufacturing catalysts
2,644

 
3,929

Recoverable VAT and other taxes
4,468

 
2,193

Other
2,063

 
3,003

Prepaid and other current assets
$
9,995

 
$
19,873


(1)  
At September 30, 2012 and December 31, 2011 , this amount includes $785,000 and $748,000 , respectively, of the current

19



unamortized portion of equipment costs funded by the Company to a contract manufacturer. The related amortization is being offset against purchases of inventory.


Property and Equipment, net

Property and equipment, net is comprised of the following (in thousands):  
 
September 30, 2012
 
December 31, 2011
Leasehold improvements
$
39,839

 
$
40,011

Machinery and equipment
61,238

 
59,657

Computers and software
7,548

 
6,491

Furniture and office equipment
2,365

 
2,223

Vehicles
511

 
596

Construction in progress
93,825

 
45,318

 
$
205,326

 
$
154,296

Less: accumulated depreciation and amortization
(40,623
)
 
(26,195
)
Property and equipment, net
$
164,703

 
$
128,101


Property and equipment includes $10.2 million and $13.7 million of machinery and equipment and furniture and office equipment under capital leases as of September 30, 2012 and December 31, 2011 , respectively. Accumulated amortization of assets under capital leases totaled $4.4 million and $4.7 million as of September 30, 2012 and December 31, 2011 , respectively.

Depreciation and amortization expense, including amortization of assets under capital leases, was $3.1 million and $3.0 million for the three months ended September 30, 2012 and 2011 , respectively and was $10.4 million and $7.5 million for the nine months ended September 30, 2012 and 2011 , respectively.

The Company capitalizes interest cost incurred to construct plant and equipment. The capitalized interest is recorded as part of the depreciable cost of the asset to which it relates to and this amount is amortized over the asset's estimated useful life. Interest cost capitalized as of September 30, 2012 and December 31, 2011 was $309,000 and zero , respectively.

Other Assets

Other assets are comprised of the following (in thousands):  
 
September 30, 2012
 
December 31, 2011
Deferred charge asset (1)
$

 
$
18,792

Deposits on property and equipment, including taxes
2,907

 
17,455

Advances to contract manufacturers, net of current portion (2)
2,419

 
2,866

Recoverable taxes on purchased property and equipment and inventories (3)
12,686

 
2,075

Other
2,121

 
1,813

Total other assets
$
20,133

 
$
43,001

______________ 
(1)  
The deferred charge asset relates to the collaboration agreement between the Company and Total (see Note 9).

(2)  
At September 30, 2012 and December 31, 2011 , the amount of $2.4 million and $2.9 million , respectively, relates to the non-current unamortized portion of equipment costs funded by the Company to a contract manufacturer. The related amortization is being offset against purchases of inventory.

(3)  
At September 30, 2012 and December 31, 2011 , $12.7 million and $2.1 million , respectively, are recoverable taxes from the Brazilian government.

 
Accrued and Other Current Liabilities

Accrued and other current liabilities are comprised of the following (in thousands):

20



 
September 30, 2012
 
December 31, 2011
Professional services
$
1,908

 
$
4,384

Accrued vacation
2,442

 
2,761

Payroll and related expenses
6,058

 
6,343

Construction in progress
1,069

 
4,992

Tax-related liabilities
620

 
2,180

Deferred rent, current portion
1,403

 
1,274

Contractual obligations to contract manufacturers
8,435

 

Customer advances
970

 
3,667

Refundable exercise price on early exercise of stock options
1

 
30

Other
1,155

 
5,351

Total accrued and other current liabilities
$
24,061

 
$
30,982


Other Liabilities

Other liabilities are comprised of the following (in thousands):
 
September 30, 2012
 
December 31, 2011
Contingently repayable advance from related party collaborator (1)
$

 
$
31,922

Bonus payable to contract manufacturer, non-current

 
2,500

Contractual obligations to contract manufacturers, non-current
4,000

 

Fair market value of swap obligations
1,126

 

Asset retirement obligations
1,129

 
1,129

Fair value of compound embedded derivative liability (2)
10,263

 

Other
2,375

 
1,534

Total other liabilities
$
18,893

 
$
37,085

______________ 
(1)  
The contingently repayable advance from related party collaborator relates to the collaboration agreement between the Company and Total which was settled in the third quarter of 2012.
(2)  
The compound embedded derivative liability represents the fair value of the equity conversion feature and a "make-whole" feature of the outstanding promissory notes issued to Total.

In November 2011, the Company and Total entered into an amendment of their Technology License, Development, Research and Collaboration Agreement (the "Amendment”). The Amendment provided for an exclusive strategic collaboration for the development of renewable diesel products and contemplated that the parties would establish a joint venture (the “JV”) for the production and commercialization of such renewable diesel products on an exclusive, worldwide basis. In addition, the Amendment contemplated providing the JV with the right to produce and commercialize certain other chemical products on a non-exclusive basis. The amendment further provided that definitive agreements to form the JV had to be in place by March 31, 2012 or such other date as agreed to by the parties or the renewable diesel program, including any further collaboration payments by Total related to the renewable diesel program, would terminate. In the second quarter of 2012, the parties extended the deadline to June 30, 2012, and, through June 30, 2012 the parties were engaged in discussions regarding the structure of future payments related to the program, until the amendment was superseded by a further amendment in July 2012 (as discussed in Note 9).

Pursuant to the Amendment, Total agreed to fund the following amounts: (i) the first $30.0 million in research and development costs related to the renewable diesel program which have been incurred since August 1, 2011, which amount would be in addition to the $50.0 million in research and development funding contemplated by the Collaboration Agreement, and (ii) for any research and development costs incurred following the JV formation date that were not covered by the initial $30.0 million , an additional $10.0 million in 2012 and up to an additional $10.0 million in 2013, which amounts would be considered part of the $50.0 million contemplated by the Collaboration Agreement. In addition to these payments, Total further agreed to fund 50%  of all remaining research and development costs for the renewable diesel program under the Amendment.

Under the Amendment,Total had an option for a period of 90 days, following the completion of the renewable diesel program on December 31, 2013 (or any other date as determined by the management committee to achieve the end-project milestone), to notify the Company that it did not wish to pursue production or commercialization of renewable diesel under the Amendment. If

21



Total exercised this right, all of Total's intellectual property rights that were developed during the renewable diesel program would terminate and would be assigned to the Company, and the Company would be obligated to pay Total specified royalties based on the Company's net income in consideration of the benefits the Company derived from the technology and intellectual property developed during the renewable diesel development project. Such royalty payments would commence on the royalty notification date and end on the date when the Company had paid Total an aggregate amount equal to $150.0 million . Such royalty payments would be equal to ( 20% ) of Company and Company-affiliate (i) net income on a yearly basis derived from licenses or sales of intellectual property developed under the collaboration other than to the extent such licenses or sales relate to the use of such intellectual property for the non-exclusive JV products, and (ii) net income of the Company on a consolidated basis other than that derived from the jet fuel development program with Total or from the non-exclusive JV products.

In addition, under the Amendment, if the Company sold all or substantially all of its renewable diesel business prior to the time the aggregate royalty amount has been paid, the Company would be required to pay Total fifty percent ( 50% ) of the net proceeds from such sale up to the then-remaining unpaid amount of the aggregate royalty amount. Net income was to be calculated in accordance with generally accepted accounting principles consistently applied by the Company and in the event that the foregoing net income was negative for a given fiscal quarter, the Company would not be required to pay any royalty for such fiscal quarter). Beginning on the sixth year from the royalty notification date, the aforementioned royalty would be additionally derived from the non-exclusive JV products.

The Company concluded that there was a significant amount of risk associated with the development of these products and therefore the arrangement is within the scope of ASC 730-20 Research and Development. The Company also determined that until Total exercised its royalty option under the Amendment, it would be uncertain that financial risk involved with research and development was transferred from the Company to Total. Accordingly, the funds received from Total for the diesel product research and development activities were recorded as a contingently repayable advance from the collaborator as part of other liabilities. Depending on the resolution of Total's royalty option contingency, the Company will record this arrangement as a contract to perform research and development services or as an obligation to repay the funds.

In July 2012, the Company entered into a further amendment of the collaboration agreement with Total that expanded Total's investment in the biofene collaboration, incorporated the development of certain joint venture products for use in diesel and jet fuel into the scope of the collaboration, and changed the structure of the funding from Total to include a convertible debt mechanism (see Note 9). As a part of the July 2012 amendments, Total's royalty option contingency related to diesel was removed and jet fuel collaboration was combined with the expanded biofene collaboration. As a result, $23.3 million of payments received from Total that had been recorded as an advance from the collaborator were no longer contingently repayable and were recorded as a contract to perform research and development services, by reducing the capitalized deferred charge asset of $14.4 million and recording revenue of $8.9 million .

5. Commitments and Contingencies

Capital Leases

In March 2008, the Company executed an equipment financing agreement intended to cover certain qualifying research and laboratory hardware and software. In January 2009, the agreement was amended to increase the financing amount. During the years ended December 31, 2011, 2010, and 2009, the Company financed certain purchases of hardware equipment and software of approximately zero , $1.4 million and $4.8 million , respectively. Pursuant to the equipment financing agreement, the Company financed the equipment with the transactions representing capital leases. Accordingly, fixed assets and capital lease liabilities were recorded at the present values of the future lease payments of $0.9 million and $3.1 million at September 30, 2012 and December 31, 2011 , respectively. The incremental borrowing rates used to determine the present values of the future lease payments was 9.5% . The capital lease obligations expire at various dates, with the latest maturity in March 2013. In connection with the agreement entered into in 2008, the Company issued a warrant to purchase shares of the Company's convertible preferred stock (see Note 11).

In December 2011, the Company executed an equipment financing agreement intended to cover certain qualifying research and laboratory hardware. During the year ended December 31, 2011, the Company financed certain purchases of hardware equipment of $3.0 million . Pursuant to the equipment financing agreement, the Company financed the equipment with transactions representing capital leases. This sale/leaseback transaction resulted in a $1.3 million unrealized loss which is being amortized over the life of the assets under lease. Accordingly, the Company recorded a capital lease liability at the present value of the future lease payments of $2.5 million at September 30, 2012 and $3.4 million at December 31, 2011 The incremental borrowing rate used to determine the present values of the future lease payments was 6.5% . The lease obligations expire on January 1, 2015 . In connection with the equipment financing transaction, the Company issued a warrant to purchase shares of the Company's common

22



stock (see Note 11). Future minimum payments under this sales/leaseback agreement as of September 30, 2012 are as follows (in thousands):
Years ending December 31:
Sale/Leaseback
2012 (Three Months)
$
274

2013
1,098

2014
1,007

2015
289

2016

Thereafter

Total future minimum lease payments
2,668

Less: amount representing interest
(207
)
Present value of minimum lease payments
2,461

Less: current portion
(966
)
Long-term portion
$
1,495

The Company recorded interest expense in connection with its capital leases of $81,000 and $126,000 for the three months ended September 30, 2012 and 2011 , respectively, and $321,000 and $437,000 for the nine months ended September 30, 2012 and 2011 , respectively. Future minimum payments under capital leases, including the sale/leaseback equipment financing agreement, as of September 30, 2012 are as follows (in thousands):
 
Years ending December 31:
Capital Leases
2012 (Three Months)
$
816

2013
1,489

2014
1,007

2015
289

2016

Thereafter

Total future minimum lease payments
3,601

Less: amount representing interest
(235
)
Present value of minimum lease payments
3,366

Less: current portion
(1,871
)
Long-term portion
$
1,495


Operating Leases

The Company has noncancelable operating lease agreements for office, research and development and manufacturing space in the United States that expire at various dates, with the latest expiration in May 2018 with an estimated annual rent payment of approximately $6.0 million . In addition, the Company leases facilities in Brazil pursuant to noncancelable operating leases that expire at various dates, with the latest expiration in November 2016 and with an estimated annual rent payment of approximately $0.6 million .

In 2007, the Company entered into an operating lease for its headquarters in Emeryville, California, with a term of ten years commencing in May 2008. As part of the operating lease agreement, the Company received a tenant improvements allowance of $11.4 million . The Company recorded the allowance as deferred rent and associated expenditures as leasehold improvements that are being amortized over the shorter of their useful life or the term of the lease. In connection with the operating lease, the Company elected to defer a portion of the monthly base rent due under the lease and entered into notes payable agreements with the lessor for the purchase of certain tenant improvements. In October 2010, the Company amended its lease agreement with the lessor of its headquarters, to lease up to approximately 22,000 square feet of research and development and office space. In return for the removal of the early termination clause in its amended lease agreement, the Company received approximately $1.0 million from the lessor in December 2010.


23



The Company recognizes rent expense on a straight-line basis over the noncancelable lease term and records the difference between cash rent payments and the recognition of rent expense as a deferred rent liability. Where leases contain escalation clauses, rent abatements, and/or concessions, such as rent holidays and landlord or tenant incentives or allowances, the Company applies them in the determination of straight-line rent expense over the lease term. Rent expense was $1.2 million and $1.2 million for the three months ended September 30, 2012 and 2011 , respectively, and $3.7 million and $3.5 million for the nine months ended September 30, 2012 and 2011 , respectively.
 
In January 2011, the Company entered into a right of first refusal agreement with respect to a facility and site in Leland, North Carolina leased by Glycotech covering a two year period commencing in January 2011. Under the right of first refusal agreement, the lessor agrees not to sell the facility and site leased by Glycotech during the term of the production service agreement. If the lessor is presented with an offer to sell, or decides to sell, an adjacent parcel, the Company has a right of first refusal to acquire the adjacent parcel or leased property.

In February 2011, the Company commenced payment of rent related to an operating lease on real property owned by Usina São Martinho in Brazil. In conjunction with a joint venture agreement (see Note 7) with the same entity, the real property will be used by the joint venture entity, SMA Indústria Química S.A. (“SMA”), for the construction of a production facility. This lease has a term of 20 years commencing in February 2011 with an estimated annual rent payment of approximately $47,000 .

In February 2011, the Company entered into an operating lease for certain equipment owned by GEA Engenharia de Processos e Sistemas Industriais Ltda (“GEA”) in Brazil. The equipment under this lease was used by the Company in its production activities in Brazil. This lease had a term of one year commencing in March 2011 and was terminated in June 2012 and the equipment was returned to GEA.

In March 2011, the Company entered into an operating lease on real property owned by Paraíso Bioenergia S.A. (“Paraíso Bioenergia”) in Brazil. In conjunction with a supply agreement (see Note 9) with the same entity, the real property is being used by the Company for the construction of an industrial facility. This lease has a term of 15 years commencing in March 2011 with an estimated annual rent payment of approximately $118,000 .

In August 2011, the Company notified the lessor of its leased office facilities in Brazil of the Company's termination of its existing lease effective November 30, 2011. At the same time, the Company entered into an operating lease for new office facilities in Campinas, Brazil. The new lease has a term of 5 years commencing in November 2011 with an estimated annual rent payment of approximately $375,000 .

Future minimum payments under operating leases as of September 30, 2012 , are as follows (in thousands):

Years ending December 31:
 
Operating
Leases -
Facilities
 
Operating
Leases -
Land
 
Total
Operating
Leases
2012 (Three Months)
$
1,658

 
$
32

 
$
1,690

2013
6,385

 
166

 
6,551

2014
6,516

 
165

 
6,681

2015
6,644

 
165

 
6,809

2016
6,630

 
165

 
6,795

Thereafter
9,233

 
1,758

 
10,991

Total future minimum lease payments
$
37,066

 
$
2,451

 
$
39,517


Guarantor Arrangements

The Company has agreements whereby it indemnifies its officers and directors for certain events or occurrences while the officer or director is, or was, serving at the Company’s request in such capacity. The term of the indemnification period is for the officer or director’s lifetime. The maximum potential amount of future payments the Company could be required to make under these indemnification agreements is unlimited; however, the Company has a director and officer insurance policy that limits its exposure and enables the Company to recover a portion of any future amounts paid. As a result of its insurance policy coverage, the Company believes the estimated fair value of these indemnification agreements is minimal. Accordingly, the Company had no liabilities recorded for these agreements as of September 30, 2012 and December 31, 2011 .
 

24



The Company has a facility (“FINEP Credit Facility”) with a financial institution to finance a research and development project on sugarcane-based biodiesel (see Note 6). The FINEP Credit Facility provides for loans of up to an aggregate principal amount of R$6.4 million (approximately US$3.2 million based on the exchange rate as of September 30, 2012 ) which is guaranteed by a chattel mortgage on certain equipment of the Company. The Company's total acquisition cost for the equipment under this guarantee is approximately R$6.0 million (approximately US$3.0 million based on the exchange rate as of September 30, 2012 ). Subject to compliance with certain terms and conditions under the FINEP Credit Facility, four disbursements of the loan will become available to the Company for withdrawal, as described in more detail in Note 6. After the release of the first disbursement, prior to any subsequent drawdown from the FINEP Credit Facility, the Company also needs to provide bank letters of guarantee of up to R$3.3 million (approximately US$1.6 million based on the exchange rate as of September 30, 2012 ).

The Company has a credit facility (“BNDES Credit Facility”) with a financial institution to finance a production site in Brazil. This credit facility is collateralized by a first priority security interest in certain of the Company's equipment and other tangible assets totaling R$24.9 million (approximately US$12.3 million based on the exchange rate at September 30, 2012 ). The Company is a parent guarantor for the payment of the outstanding balance under the BNDES Credit Facility. Additionally, the Company is required to provide a bank guarantee under the BNDES Credit Facility.

The Company has signed loan agreements and a security agreement where the Company pledged certain farnesene production system as collateral (the fiduciary conveyance of movable goods) with each of Nossa Caixa and Banco Pine. Under the loan agreements, Banco Pine, agreed to lend R$22.0 million and Nossa Caixa agreed to lend R$30.0 million as financing for capital expenditures relating to the Company's manufacturing facility at Paraíso Bioenergia in Brazil. The Company's total acquisition cost for the farnesene production system pledged as collateral under these agreements is approximately R$68.0 million (approximately US$33.5 million based on the exchange rate as of September 30, 2012 ). The Company is a also a parent guarantor for the payment of the outstanding balance under these loan agreements. 

Under an operating lease agreement for its office facilities in Brazil, which commenced on November 15, 2011, the Company is required to maintain restricted cash or letters of credit equal to three months of rent of approximately R$191,000 (approximately US$94,000 based on the exchange rate as of September 30, 2012 ) in the aggregate as a guarantee that the Company will meet its performance obligations under such operating lease agreement.

Other Matters
Certain conditions may exist as of the date the financial statements are issued, which may result in a loss to the Company but which will only be resolved when one or more future events occur or fail to occur. The Company's management assesses such contingent liabilities, and such assessment inherently involves an exercise of judgment. In assessing loss contingencies related to legal proceedings that are pending against and by the Company or unasserted claims that may result in such proceedings, the Company's management evaluates the perceived merits of any legal proceedings or unasserted claims as well as the perceived merits of the amount of relief sought or expected to be sought.
If the assessment of a contingency indicates that it is probable that a material loss has been incurred and the amount of the liability can be estimated, then the estimated liability would be accrued in the Company's financial statements. If the assessment indicates that a potential material loss contingency is not probable but is reasonably possible, or is probable but cannot be estimated, then the nature of the contingent liability, together with an estimate of the range of possible loss if determinable and material would be disclosed. Loss contingencies considered to be remote by management are generally not disclosed unless they involve guarantees, in which case the guarantee would be disclosed.
The Company is subject to disputes and claims that arise or have arisen in the ordinary course of business and that have not resulted in legal proceedings or have not been fully adjudicated. For example, one of our contract manufacturers recently sent us a notice of termination and demanded payment of certain ongoing costs and removal of our equipment in connection with our decision to halt production at that plant. Another of our contract manufacturers similarly made claims that we had breached an agreement by suspending production at that plant. The Company has accrued for losses it deems to be probable arising from these claims. However, such matters are subject to many uncertainties and outcomes are not predictable with assurance. Therefore, if one or more of these legal matters were resolved against the Company for amounts in excess of management’s expectations, the Company’s consolidated financial statements for the relevant reporting period could be materially adversely affected.




25



6. Debt

Debt is comprised of the following (in thousands):
 
September 30, 2012
 
December 31, 2011
Credit facilities
$
10,238

 
$
18,852

Notes payable
1,689

 
3,113

Convertible notes
67,591

 

Loans payable
25,892

 
19,359

Total debt
105,410

 
41,324

Less: current portion
(2,121
)
 
(28,049
)
Long-term debt
$
103,289

 
$
13,275


Credit Facility

In November 2010, the Company entered into a credit facility with Financiadora de Estudos e Projetos (“FINEP”), a state-owned company subordinated to the Brazilian Ministry of Science and Technology. This FINEP Credit Facility was extended to partially fund expenses related to the Company’s research and development project on sugarcane-based biodiesel (“FINEP Project”) and provides for loans of up to an aggregate principal amount of R$6.4 million (approximately US$3.2 million based on the exchange rate as of September 30, 2012 ) which is secured by a chattel mortgage on certain equipment of the Company as well as by bank letters of guarantee. Subject to compliance with certain terms and conditions under the FINEP Credit Facility, four disbursements of the loan will become available to the Company for withdrawal. The first disbursement received in February 2011 was approximately R$1.8 million (approximately US$0.9 million based on the exchange rate as of September 30, 2012 ) and the next three disbursements will each be approximately R$1.6 million (approximately US$0.8 million based on exchange rate as of September 30, 2012 ). As of September 30, 2012 and December 31, 2011 there was R$1.8 million (approximately US$0.9 million based on the exchange rate at September 30, 2012 ) outstanding under this FINEP Credit Facility.

Interest on loans drawn under this credit facility is fixed at 5.0%  per annum. In case of default under or non-compliance with the terms of the agreement, the interest on loans will be dependent on the long-term interest rate as published by the Central Bank of Brazil (“TJLP”). If the TJLP at the time of default is greater than 6.0% , then the interest will be 5.0% plus a TJLP adjustment factor, otherwise the interest will be at 11.0%  per annum. In addition, a fine of up to 10.0% shall apply to the amount of any obligation in default. Interest on late balances will be 1.0% interest per month, levied on the overdue amount. Payment of the outstanding loan balance is being made in 81 monthly installments which commenced in July 2012 and extends through March 2019. Commencing in March 2011, interest on loans drawn and other charges have been paid on a monthly basis.

The FINEP Credit Facility contains the following significant terms and conditions
The Company will share with FINEP the costs associated with the FINEP Project. At a minimum, the Company will contribute from its own funds approximately R$14.5 million (approximately US$7.1 million based on the exchange rate as of September 30, 2012 ) of which the Company expects R$11.1 million to be contributed prior to the release of the second disbursement, which is expected to occur in 2013;
After the release of the first disbursement, prior to any subsequent drawdown from the FINEP Credit Facility, the Company is required to provide bank letters of guarantee of up to R$3.3 million in aggregate (approximately US$1.6 million based on the exchange rate as of September 30, 2012 );
Amounts released from the FINEP Credit Facility must be completely used by the Company towards the FINEP Project within 30 months after the contract execution.

Notes Payable

During the period between May 2008 and October 2008, the Company entered into notes payable agreements with the lessor of its headquarters under which it borrowed a total of $3.3 million for the purchase of tenant improvements, bearing an interest rate of 9.5%  per annum and to be repaid over a period of 55 to 120 months. As of September 30, 2012 and December 31, 2011 , a principal amount of $1.6 million and $2.0 million , respectively, was outstanding under these notes payable.

In connection with the operating lease for its headquarters (see Note 5) in Emeryville, California, the Company elected

26



to defer a portion of monthly base rent due under the lease. In June 2011, a deferred rent obligation of $1.5 million resulting from this election became due and payable in 24 equal monthly installments of approximately $63,000 . As such, the Company reclassified this obligation from Other Liabilities to Notes Payable. In June 2012, the Company paid off the outstanding notes payable balance. As of September 30, 2012 and December 31, 2011 , a principal amount of zero and $1.1 million , respectively, was outstanding under this note payable.

Convertible Notes

In February 2012, the Company completed the sale of unsecured senior convertible promissory notes in an aggregate principal amount of $25.0 million pursuant to a Securities Purchase Agreement, between the Company and certain investment funds affiliated with Fidelity Investments Institutional Services Company, Inc. The offering consisted of the sale of 3% senior unsecured convertible promissory notes with a March 1, 2017 maturity date and a conversion price equal to $7.0682 per share of common stock, subject to adjustment for proportional adjustments to outstanding common stock and anti-dilution provisions in case of dividends and distributions. As of September 30, 2012 , the notes were convertible into an aggregate of up to 3,536,968 shares of common stock. The note holders have a right to require repayment of 101% of the principal amount of the notes in an acquisition of the Company, and the notes provide for payment of unpaid interest on conversion following such an acquisition if the note holders do not require such repayment.  The securities purchase agreement and notes include covenants regarding payment of interest, maintaining the Company's listing status, limitations on debt, maintenance of corporate existence, and filing of SEC reports. The notes include standard events of default resulting in acceleration of indebtedness, including failure to pay, bankruptcy and insolvency, cross-defaults, material adverse effect clauses and breaches of the covenants in the securities purchase agreement and notes, with default interest rates and associated cure periods applicable to the covenant regarding SEC reporting.

In July 2012 , the Company entered into a further amendment of the collaboration agreement with Total that expanded Total's investment in the biofene collaboration, incorporated the development of certain joint venture products for use in diesel and jet fuel into the scope of the collaboration, and changed the structure of the funding from Total to include a convertible debt mechanism (see Note 9).

The purchase agreement for the notes related to the funding from Total provides for the sale of an aggregate of $105.0 million in notes as follows:

As part of an initial closing under the purchase agreement (which initial closing was completed in two installments), (i) on July 30, 2012 , the Company sold a 1.5% Senior Unsecured Convertible Note Due 2017 to Total in the face amount of $38.3 million , including $15.0 million in new funds and repayment by the Company of $23.3 million in previously-provided diesel research and development funding by Total, and (ii) on September 14, 2012 , the Company sold another note (in the same form) for $15.0 million in new funds from Total.
The purchase agreement provides that additional notes may be sold in subsequent closings in July 2013 (for cash proceeds to the Company of $30.0 million ) and July 2014 (for cash proceeds to the Company of $21.7 million , which would be settled in an initial installment of $10.85 million payable at such closing and a second installment of $10.85 million payable in January 2015 ).

The notes each have a March 1, 2017 maturity date and a conversion price equal to $7.0682 per share of Company common stock. The notes bear interest of 1.5% per year (with a default rate of 2.5% ), accruing from date of funding and payable at maturity or on conversion or a change of control where Total exercises the right to require the Company to repay the notes. Accrued interest is canceled if the notes are canceled based on a “Go” decision.

The notes become convertible into Company common stock (i) within 10 trading days prior to maturity (if they are not canceled as described above prior to their maturity date), (ii) on a change of control of the Company, (iii) if Total is no longer the largest stockholder of the Company following a “No-Go” decision (subject to a six -month lock-up with respect to any shares of common stock issued upon conversion), and (iv) on a default by the Company. If Total makes a final “Go” decision, then the notes will be exchanged by Total for equity interests in the Fuels JV, after which the notes will not be convertible and any obligation to pay principal or interest on the notes will be extinguished. If Total makes a “No-Go” decision, outstanding notes will remain outstanding and become payable at maturity.

The conversion price of the notes is subject to adjustment for proportional adjustments to outstanding common stock and under anti-dilution provisions in case of certain dividends and distributions. Total has a right to require repayment of

27



101% of the principal amount of the notes in the event of a change of control of the Company and the notes provide for payment of unpaid interest on conversion following such a change of control if Total does not require such repayment. The purchase agreement and notes include covenants regarding payment of interest, maintenance of the Company's listing status, limitations on debt, maintenance of corporate existence, and filing of SEC reports. The notes include standard events of default resulting in acceleration of indebtedness, including failure to pay, bankruptcy and insolvency, cross-defaults, and breaches of the covenants in the purchase agreement and notes, with added default interest rates and associated cure periods applicable to the covenant regarding SEC reporting.

Loans Payable

In December 2009, the Company entered into a loans payable agreement with the lessor of its Emeryville pilot plant under which it borrowed a total of $250,000 , bearing an interest rate of 10.0%  per annum and to be repaid over a period of 96  months. As of September 30, 2012 and December 31, 2011 , a principal amount of $184,000 and $204,000 , respectively, was outstanding under the loan.

In December 2011, the Company entered into a loan agreement with Banco Pine under which Banco Pine provided the Company with a short term loan of R$35.0 million (approximately US$17.2 million based on the exchange rate as of September 30, 2012 ). Such loan was an advance on anticipated July 2012 financing from Nossa Caixa Desenvolvimento, ("Nossa Caixa"), the Sao Paulo State development bank, and Banco Pine, under which Banco Pine and Nossa Caxia would provide the Company with loans of up to approximately R$52.0 million (approximately US$25.6 million based on the exchange rate as of September 30, 2012 ) as financing for capital expenditures relating to the Company's manufacturing facility at Paraíso Bioenergia. The interest rate for the loan was 119.2% of the Brazilian interbank lending rate (approximately 12.3% on an annualized basis). The principal and interest of loans under the loan agreement, as amended, matured and were required to be repaid on August 15, 2012 .
In June 2012, the Company entered into a separate loan agreement with Banco Pine under which Banco Pine provided the Company with a short-term bridge loan of R$52.0 million (approximately US$25.6 million based on the exchange rate as of September 30, 2012 ). The bridge loan was an additional advance on the anticipated Banco Pine and Nossa Caixa financing described above. The interest rate for the bridge loan was 0.4472% monthly (approximately 5.5% on an annualized basis). The principal and interest under the bridge loan matured and were required to be repaid on September 19, 2012 , subject to extension by Banco Pine. The bridge loan was in addition to the R$35.0 million short term loan to the Company described above. At the time of this bridge loan, the Company entered into a currency interest rate swap arrangement with the lender for R$22.0 million (approximately US$10.8 million based on the exchange rate as of September 30, 2012 ). The swap arrangement exchanged the principal and interest payments under the bridge loan for alternative principal and interest payments that were subject to adjustment based on fluctuations in the foreign exchange rate between the U.S. dollar and Brazilian real. The swap had a fixed interest rate of 3.94% .
In July 2012, the Company entered into a Note of Bank Credit and a Fiduciary Conveyance of Movable Goods agreements with each of Nossa Caixa and Banco Pine. Under these agreements, the Company's total acquisition cost for the farnesene production system pledged as collateral is approximately R$68.0 million (approximately US$33.5 million based on the exchange rate as of September 30, 2012 ). The Company is a also a parent guarantor for the payment of the outstanding balance under these loan agreements.
Under such instruments, the Company could borrow an aggregate of R$52.0 million (approximately US$25.6 million based on the exchange rate as of September 30, 2012 ) as financing for capital expenditures relating to the Company's manufacturing facility at Paraíso Bioenergia in Brazil.  Under the loan agreements, Banco Pine, agreed to lend R$22.0 million and Nossa Caixa agreed to lend R$30.0 million .  The funds for the loans are provided by Banco Nacional de Desenvolvimento Econômico e Social ("BNDES"), but are guaranteed by the lenders. The loans have a final maturity date of July 15, 2022 and bear a fixed interest rate of 5.5% per year.  For the first two years that the loans are outstanding, the Company is required to pay interest only on a quarterly basis.  After August 15, 2014 , the Company is required to pay equal monthly installments of both principal and interest for the remainder of the term of the loans. In July 2012, the Company repaid the outstanding bridge loans of R$52.0 million and R$35.0 million from Banco Pine.

Letters of Credit

In November 2008, the Company entered into the Credit Agreement with a financial institution to finance the purchase and sale of fuel and for working capital requirements, as needed. In October 2009, the agreement was amended to decrease the maximum amount that the Company may borrow under such facility. The Credit Agreement, as amended, provided, as of March 31, 2012, for an aggregate maximum availability up to the lower of $20.0 million and the borrowing base as defined

28



in the agreement, and was subject to a sub-limit of $5.7 million for the issuance of letters of credit and a sub-limit of $20.0 million for short-term cash advances for product purchases. The Credit Agreement was collateralized by a first priority security interest in certain of the Company’s present and future assets. Amyris was a parent guarantor for the payment of the outstanding balance under the Credit Agreement. Outstanding advances bore an interest rate at the Company’s option of the bank’s prime rate plus 1.0% or the bank’s cost of funds plus 3.5% . In April 2012, the Company, entered into an Amendment to the credit agreement, effective as of April 14, 2012 to extend the maturity date pending the Company's transition out of its ethanol and reformulated ethanol-blended gasoline business, and its plan to repay all amounts remaining outstanding under the Credit Agreement, and terminate the Credit Agreement as of the new maturity date. As of September 30, 2012 , the Credit Agreement was terminated. As of September 30, 2012 and December 31, 2011 , the Company had no outstanding advances and had zero and $5.0 million , respectively, in outstanding letters of credit under the Credit Agreement.

In June 2012, the Company entered into a letter of credit agreement for $953,000 , under which it provided a letter of credit to the landlord for its headquarters in Emeryville, California in order to cover the security deposit on the lease. The letter of credit is secured by a certificate of deposit. Accordingly, the Company recorded $954,000 as restricted cash as of September 30, 2012 .

Revolving Credit Facility

In December 2010, the Company established a revolving credit facility with a financial institution that provided for loans and standby letters of credit of up to an aggregate principal amount of $10.0 million with a sublimit of $5.0 million on standby letters of credit. Interest on loans drawn under this revolving credit facility was equal to (i) the Eurodollar Rate plus 3.0% ; or (ii) the Prime Rate plus 0.5% . In case of default or non-compliance with the terms of the agreement, the interest on loans was Prime Rate plus 2.0% . The credit facility was collateralized by a first priority security interest in certain of the Company's present and future assets. In April 2012, the Company paid $7.7 million of its outstanding loans under the Credit Facility. In May 2012, the Company entered into a letter agreement with the bank amending the credit facility agreement to reduce the committed amount under the credit facility from $10.0 million to approximately $2.3 million , and the letters of credit sublimit from $5.0 million to approximately $2.3 million . The amendment also modified the current ratio covenant to require a ratio of current assets to current liabilities of at least 1.3 :1 (as compared to 2 :1 in the Credit Facility), and required the Company to maintain unrestricted cash of at least $15.0 million in its account with the Bank. In June 2012, the credit facility was terminated and, as of September 30, 2012 , no loans or letters of credit were outstanding.

BNDES Credit Facility

In December 2011, the Company entered into a credit facility (the "BNDES Credit Facility") in the amount of R$22.4 million (approximately US $11.0 million based on the exchange rate as of September 30, 2012 ) with BNDES, a government owned bank headquartered in Brazil. This BNDES facility was extended as project financing for a production site in Brazil. The credit line is divided into an initial tranche for up to approximately R$19.1 million and an additional tranche of approximately R$3.3 million that becomes available upon delivery of additional guarantees. The credit line is available for 12 months from the date of the Credit Agreement, subject to extension by the lender.
The principal of the loans under the BNDES Credit Facility is required to be repaid in 60 monthly installments, with the first installment due in January 2013 and the last due in December 2017. Interest is due initially on a quarterly basis and the first installment was paid in March 2012. From and after January 2013, payments of principal and interest will be due on a monthly basis. The loaned amounts carry interest of 7%  per year. Additionally, a credit reserve charge of 0.1% on the unused balance from each credit installment from the day immediately after it is made available through its date of use, when it is paid.

The BNDES Credit Facility is denominated in Brazilian reais. The credit facility is collateralized by a first priority security interest in certain of the Company's equipment and other tangible assets totaling R$24.9 million (approximately US $12.3 million based on the exchange rate as of September 30, 2012 ). The Company is a parent guarantor for the payment of the outstanding balance under the BNDES Credit Facility. Additionally, the Company is required to provide a bank guarantee equal to 10% of the total approved amount ( R$22.4 million in total debt) available under this credit facility. For advances of the second tranche (above R$19.1 million ), the Company is required to provide additional bank guarantees equal to 90% of each such advance, plus additional Company guarantees equal to at least 130% of such advance. The BNDES Credit Facility contains customary events of default, including payment failures, failure to satisfy other obligations under this credit facility or related documents, defaults in respect of other indebtedness, bankruptcy, insolvency and inability to pay debts when due, material judgments, and changes in control of Amyris Brasil. If any event of default occurs, the Lender may terminate its commitments and declare immediately due all borrowings under the facility. As of September 30, 2012 the Company had R$19.1 million (approximately US$9.4 million based on the exchange rate as of September 30, 2012 ) in

29



outstanding advances under the BNDES Credit Facility.

Future minimum payments under the debt agreements as of September 30, 2012 are as follows (in thousands):

Years ending December 31:
Notes Payable
 
Convertible Notes
 
Loans Payable
 
Credit Facility
2012 (Three Months)
$
156

 
$
192

 
$
670

 
$
370

2013
445

 
760

 
1,534

 
2,632

2014
355

 
760

 
2,495

 
2,497

2015
355

 
765

 
3,914

 
2,361

2016
355

 
761

 
3,823

 
2,226

Thereafter
479

 
81,958

 
19,400

 
2,255

Total future minimum payments
2,145

 
85,196

 
31,836

 
12,341

Less: amount representing interest
(456
)
 
(17,605
)
 
(5,944
)
 
(2,103
)
Present value of minimum debt payments
1,689

 
67,591

 
25,892

 
10,238

Less: current portion
(371
)
 

 
(127
)
 
(1,623
)
Noncurrent portion of debt
$
1,318

 
$
67,591

 
$
25,765

 
$
8,615



7. Joint Ventures

SMA Indústria Química S.A.

On April 14, 2010, the Company established SMA, a joint venture with Usina São Martinho, to build a manufacturing facility. SMA is located at the Usina São Martinho mill in Pradópolis, São Paulo state, Brazil. SMA has a 20 year initial term.

SMA is managed by a three member executive committee, of which the Company appoints two members one of whom is the plant manager who is the most senior executive responsible for managing the construction and operation of the facility. SMA is governed by a four member board of directors, of which the Company and Usina São Martinho each appoint two members. The board of directors has certain protective rights which include final approval of the engineering designs and project work plan developed and recommended by the executive committee.

The joint venture agreements require the Company to fund the construction costs of the new facility and Usina São Martinho would reimburse the Company up to R$61.8 million (approximately US$30.4 million based on the exchange rate as of September 30, 2012 ) of the construction costs after SMA commences production. Post commercialization, the Company would market and distribute Amyris renewable products and Usina São Martinho would sell feedstock and provide certain other services to SMA. The cost of the feedstock to SMA would be a price that is based on the average return that Usina São Martinho could receive from the production of its current products, sugar and ethanol. The Company would be required to purchase the output of SMA for the first four years at a price that guarantees the return of Usina São Martinho’s investment plus a fixed interest rate. After this four year period, the price would be set to guarantee a break-even price to SMA plus an agreed upon return.

Under the terms of the joint venture agreements, if the Company becomes controlled, directly or indirectly, by a competitor of Usina São Martinho, then Usina São Martinho has the right to acquire the Company’s interest in SMA. If Usina São Martinho becomes controlled, directly or indirectly, by a competitor of the Company, then the Company has the right to sell its interest in SMA to Usina São Martinho. In either case, the purchase price is determined in accordance with the joint venture agreements, and the Company would continue to have the obligation to acquire products produced by SMA for the remainder of the term of the supply agreement then in effect even though the Company would no longer be involved in SMA’s management.

Amyris has a 50% ownership interest in SMA. The Company has identified SMA as a VIE. The Company is the primary beneficiary and consequently consolidates SMA’s operations in its financial statements.

Joint Venture with Cosan

In June 2011, the Company entered into joint venture agreements with Cosan Combustíveis e Lubrificantes S.A. and Cosan S.A. Industria e Comércio (such Cosan entities, collectively or individually, “Cosan”), related to the formation of a joint venture (the “Novvi JV”), to focus on the worldwide development, production and commercialization of base oils made from Biofene

30



produced by the Novvi JV or purchased from the Company or a contract manufacturer. The Company and Cosan are establishing entities related to the joint venture in both Brazil and the United States.

Under the joint venture agreements, the Novvi JV would undertake, on a worldwide basis, the development, production and commercialization of certain classes of base oils produced from Biofene for use in lubricants products in the automotive, commercial and industrial markets. The agreements provide that (i) the Company will perform research and development activities on behalf of the Novvi JV under a research services arrangement and will grant a royalty-free license to the Novvi JV to use the Company's technology to develop, produce, market and distribute renewable base oils for use in lubricant products sold worldwide, and (ii) Cosan will provide technical expertise and use commercially reasonable efforts to contribute a base oils offtake agreement with a third party to the Novvi JV.

Subject to certain exceptions for the Company, the joint venture agreements provide that the Novvi JV will be the exclusive means through which the Company and Cosan will engage in the worldwide development and commercialization of specified classes of renewable base oils that are derived from Biofene or, under certain circumstances, from other intermediate molecules or technologies. The JV has certain rights of first refusal with respect to alternative base oil technologies that may be acquired by the Company or Cosan during the term of the Novvi JV.

Under the joint venture agreements, the Company and Cosan each own 50% of the Novvi JV and each party will share equally in any costs and any profits ultimately realized by the JV. The joint venture agreement has an initial term of 20 years from the date of the agreement, subject to earlier termination by mutual written consent or by a non-defaulting party in the event of specified defaults by the other party (including breach by a party of any material obligations under the joint venture agreements). The Shareholders' Agreement has an initial term of 10 years from the date of the agreement, subject to earlier termination if either the Company or Cosan ceases to own at least 10% of the voting stock of the Novvi JV.

The Company has identified Novvi S.A., the initial Brazilian JV entity formed, as a VIE. The power to direct activities, which most significantly impact the economic success of the joint venture, is equally shared between the Company and Cosan, who are not related parties. Accordingly, the Company is not the primary beneficiary and therefore will account for its investment in the JV entity using the equity method. The Company will periodically review its consolidation analysis on an ongoing basis. As of September 30, 2012 , the carrying amounts of the unconsolidated JV entity's assets and liabilities were not material to the Company's consolidated financial statements.

In September 2011, the U.S. JV entity, Novvi LLC was formed. The Company and Cosan are still finalizing operating agreements for this new entity. As of September 30, 2012 , there had been no activity in this joint venture.


8. Noncontrolling Interest

Redeemable Noncontrolling Interest

In December 2009, Amyris Brasil sold 1,111,111 of its shares representing a 4.8% interest in Amyris Brasil for R$ 10.0 million . This redeemable noncontrolling interest was reported in the mezzanine equity section of the consolidated balance sheet because the Company was then subject to a contingent put option under which it could have been required to repurchase an interest in Amyris Brasil from the noncontrolling interest holder.

In March 2010, Amyris Brasil sold an additional 853,333 shares of its stock, an incremental 3.4% interest, for R$ 3.0 million . In May 2010, Amyris Brasil sold an additional 1,111,111 shares of its stock, an incremental 4.07% interest, for R$ 10.0 million .

Under the terms of the agreements with these Amyris Brasil investors, the Company had the right to require the investors to convert their shares of Amyris Brasil into shares of common stock at a 1: 0.28 conversion ratio. On September 30, 2010, in connection with the Company’s IPO, shares of Amyris Brasil held by these investors were converted into 861,155 shares of the Company’s common stock. The remaining noncontrolling interest as of September 30, 2010 was converted to common stock and additional paid-in capital.

At the closing of the IPO, the Company recorded a one-time beneficial conversion feature charge of $2.7 million associated with the conversion of the shares of Amyris Brasil held by investors into shares of Amyris, Inc. common stock, which impacted earnings per share for the year ended December 31, 2010.

The following table provides a roll forward of the redeemable noncontrolling interest (in thousands):
 

31



Balance as of December 31, 2009
$
5,506

Proceeds from redeemable noncontrolling interest
7,041

Conversion of shares of Amyris Brasil S.A. subsidiary held by third parties into common stock
(11,870
)
Foreign currency translation adjustment
217

Net loss
(894
)
Balance as of December 31, 2010
$


Noncontrolling Interest

SMA Indústria Química
The joint venture, SMA (see Note 7), is a VIE pursuant to the accounting guidance for consolidating VIEs because the amount of total equity investment at risk is not sufficient to permit SMA to finance its activities without additional subordinated financial support, as well as the related commercialization agreement provides a substantive minimum price guarantee. Under the terms of the joint venture agreement, the Company directs the design and construction activities, as well as production and distribution. In addition, the Company has the obligation to fund the design and construction activities until commercialization is achieved. Subsequent to the construction phase, both parties equally fund SMA for the term of the joint venture. Based on those factors, the Company was determined to have the power to direct the activities that most significantly impact SMA’s economic performance and the obligation to absorb losses and the right to receive benefits. Accordingly, the financial results of SMA are included in the Company’s consolidated financial statements and amounts pertaining to Usina São Martinho’s interest in SMA are reported as noncontrolling interests in subsidiaries.

Glycotech

In January 2011, the Company entered into a production service agreement with Glycotech, whereby Glycotech is to provide process development and production services for the manufacturing of various Company products at its leased facility in Leland, North Carolina. The Company products to be manufactured by Glycotech will be owned and distributed by the Company. Pursuant to the terms of the agreement, the Company is required to pay the manufacturing and operating costs of the Glycotech facility which is dedicated solely to the manufacture of Amyris products. The initial term of the agreement is for a two year period commencing on February 1, 2011 and will renew automatically for successive one -year terms, unless terminated by the Company. On the same date as the production service agreement, the Company also entered into a right of first refusal agreement with the lessor of the facility and site leased by Glycotech covering a two year period commencing in January 2011. Per the terms of the right of first refusal agreement the lessor agreed not to sell the facility and site leased by Glycotech during the term of the production service agreement. In the event that the lessor is presented with an offer to sell or decides to sell an adjacent parcel, the Company has the right of first refusal to acquire it.

The Company has determined that the arrangement with Glycotech qualifies as a VIE. The Company determined that it is the primary beneficiary of this arrangement since it has the power through the management committee over which it has majority control to direct the activities that most significantly impact the arrangement's economic performance. In addition, the Company is required to fund 100% of Glycotech's actual operating costs for providing services each month while the facility is in operation under the production service agreement. Accordingly, the Company consolidates the financial results of Glycotech. As of September 30, 2012 , the carrying amounts of the consolidated VIE's assets and liabilities were not material to the Company's consolidated financial statements.

The table below reflects the carrying amount of the assets and liabilities of the two consolidated VIEs for which the Company is the primary beneficiary. The assets include $24.9 million in property and equipment and $4.8 million in other assets, and $0.3 million in current assets. The liabilities include $0.8 million in accounts payable and accrued current liabilities and $0.1 million in loan obligations by Glycotech to a financial institution that are non-recourse to the Company. The creditors of each consolidated VIE have recourse only to the assets of that VIE.

(In thousands)
September 30, 2012
 
December 31, 2011
Assets
$
29,964

 
$
22,094

Liabilities
$
921

 
$
2,873


The change in noncontrolling interest for the nine months ended September 30, 2012 and 2011 is summarized below (in

32



thousands):
 
2012
 
2011
Balance at January 1
$
(240
)
 
$
2

Addition to noncontrolling interest

 
369

Foreign currency translation adjustment
209

 

Loss attributable to noncontrolling interest
(772
)
 
(437
)
Balance at September 30
$
(803
)
 
$
(66
)


9. Significant Agreements

Research and Development Activities

Total Collaboration Agreement

In June 2010, the Company entered into a technology license, development, research and collaboration agreement (“collaboration agreement”) with Total Gas & Power USA Biotech, Inc., an affiliate of Total S.A. (Total S.A. and its relevant affiliates, collectively, “Total”). The collaboration agreement sets forth the terms for the research, development, production and commercialization of certain to be determined chemical and/or fuel products made through the use of the Company’s synthetic biology platform. The collaboration agreement establishes a multi-phased process through which projects are identified, screened, studied for feasibility, and ultimately selected as a project for development of an identified lead compound using an identified microbial strain. Under the terms of the collaboration agreement, Total will fund up to the first $50.0 million in research and development costs for the selected projects; thereafter the parties will share such costs equally. Amyris has agreed to dedicate the laboratory resources needed for collaboration projects. Total also plans to second employees at Amyris to work on the projects. Once a development project has commenced, the parties are obligated to work together exclusively to develop the lead compound during the project development phase. After a development project is completed, the Company and Total expect to form one or more joint ventures to commercialize any products that are developed, with costs and profits to be shared on an equal basis, provided that if Total has not achieved profits from sales of a joint venture product equal to the amount of funding it provided for development plus an agreed upon rate of return within three years of commencing sales, then Total will be entitled to receive all profits from sales until this rate of return has been achieved. Each party has certain rights to independently produce commercial quantities of these products under certain circumstances, subject to paying royalties to the other party. Total has the right of first negotiation with respect to exclusive commercialization arrangements that the Company would propose to enter into with certain third parties, as well as the right to purchase any of the Company’s products on terms no less favorable than those offered to or received by the Company from third parties in any market where Total or its affiliates have a significant market position.

The collaboration agreement has an initial term of 12 years and is renewable by mutual agreement by the parties for additional three year periods. Neither the Company nor Total has the right to terminate the agreement voluntarily. The Company and Total each have the right to terminate the agreement in the event the other party commits a material breach, is the subject of certain bankruptcy proceedings or challenges a patent licensed to it under the collaboration agreement. Total also has the right to terminate the collaboration agreement in the event the Company undergoes a sale or change of control to certain entities. If the Company terminates the collaboration agreement due to a breach, bankruptcy or patent challenge by Total, all licenses the Company has granted to Total terminate except licenses related to products for which Total has made a material investment and licenses related to products with respect to which binding commercialization arrangements have been approved, which will survive subject, in most cases, to the payment of certain royalties by Total to the Company. Similarly, if Total terminates the collaboration agreement due to a breach, bankruptcy or patent challenge by the Company, all licenses Total has granted to the Company terminate except licenses related to products for which the Company has made a material investment, certain grant-back licenses and licenses related to products with respect to which binding commercialization arrangements have been approved, which will survive subject, in most cases, to the payment of certain royalties to Total by the Company. On expiration of the collaboration agreement, or in the event the collaboration agreement is terminated for a reason other than a breach, bankruptcy or patent challenge by one party, licenses applicable to activities outside the collaboration generally continue with respect to intellectual property existing at the time of expiration or termination subject, in most cases, to royalty payments. There are circumstances under which certain of the licenses granted to Total will survive on a perpetual, royalty-free basis after expiration or termination of the collaboration agreement. Generally these involve licenses to use the Company’s synthetic biology technology and core metabolic pathway for purposes of either independently developing further improvements to marketed collaboration technologies or products or the processes for producing them within a specified scope agreed to by the Company and Total prior to the time of expiration or termination, or independently developing early stage commercializing products developed from collaboration compounds that met certain performance criteria prior to the time the agreement expired or was terminated and commercializing products related to such

33



compounds. After the collaboration agreement expires, the Company may be obligated to provide Total with ongoing access to Amyris laboratory facilities to enable Total to complete research and development activities that commenced prior to termination.

In June 2010, concurrent with the collaboration agreement, the Company issued 7,101,548 shares of Series D preferred stock to Total for aggregate proceeds of approximately $133.0 million at a per share price of $18.75 , which was lower than the per share fair value of common stock as determined by management and the Board of Directors. Due to the fact the collaboration agreement and the issuance of shares to Total occurred concurrently, the terms of both the collaboration agreement and the issuance of preferred stock were evaluated to determine whether their separately stated pricing was equal to the fair value of services and preferred stock. The Company determined that the fair value of Series D preferred stock was $22.68 at the time of issuance and, therefore, the Company measured the preferred stock initially at its fair value with a corresponding reduction in the consideration for the services under the collaboration agreement. As revenue from collaboration agreement will be generated over a period of time based on the performance requirements, the Company recorded the difference between the fair value and consideration received for Series D preferred stock of $27.9 million as a deferred charge asset within other assets at the time of issuance which will be recognized as a reduction to revenue in proportion to the total estimated revenue under the collaboration agreement. As of September 30, 2012 and December 31, 2011 , the Company had recognized a cumulative reduction of $27.9 million and $9.1 million , respectively, against the deferred charge asset.

As a result of recording Series D preferred stock at its fair value, the effective conversion price was greater than the fair value of common stock as determined by management and the Board of Directors. Therefore, no beneficial conversion feature was recorded at the time of issuance. The Company further determined that the conversion option with a contingent reduction in the conversion price upon a qualified IPO was a potential contingent beneficial feature and, as a result, the Company calculated the intrinsic value of such conversion option upon occurrence of the qualified IPO. The Company determined that a contingent beneficial conversion feature existed and the Company recorded a charge within the equity section of its balance sheet, which impacted earnings per share for the year ended December 31, 2010, based upon the price at which shares were offered to the public in the IPO in relation to the adjustment provisions provided for the Series D preferred stock. Based on the IPO price of $16.00 per share, the charge to net loss attributable to Amyris’ common stockholders was $39.3 million .
 
In connection with Total’s equity investment, the Company agreed to appoint a person designated by Total to serve as a member of the Company’s Board of Directors in the class subject to the latest reelection date, and to use reasonable efforts, consistent with the Board of Directors’ fiduciary duties, to cause the director designated by Total to be re-nominated by the Board of Directors in the future. These membership rights terminate upon the earlier of Total holding less than half of the shares of common stock originally issuable upon conversion of the Series D preferred stock or a sale of the Company.

The Company also agreed with Total that, so long as Total holds at least 10% of the Company’s voting securities, the Company will notify Total if the Company’s Board of Directors seeks to cause the sale of the Company or if the Company receives an offer to be acquired. In the event of such decision or offer, the Company must provide Total with all information given to an offering party and certain other information, and Total will have an exclusive negotiating period of 15 business days in the event the Board of Directors authorizes the Company to solicit offers to buy the Company, or five business days in the event that the Company receives an unsolicited offer to be acquired. This exclusive negotiation period will be followed by an additional restricted negotiation period of 10 business days, during which the Company will be obligated to negotiate with Total and will be prohibited from entering into an agreement with any other potential acquirer. Total has also entered into a standstill agreement pursuant to which it agreed for a period of three years not to acquire in excess of the greater of 20% or the number of shares of Series D preferred stock purchased by Total (during the initial two years) or 30% (during the third year) of the Company’s common stock without the prior consent of the Company's Board of Directors, except that, among other things, if another person acquires more than Total’s then current holdings of the Company’s common stock, then Total may acquire up to that amount plus one share.

In November 2011, the Company and Total entered into an amendment of the collaboration agreement as described above in Note 4 under "Other Liabilities".

In July 2012 , the Company entered into an amendment of its collaboration agreement with Total and related agreements. Under such July agreements, the scope of the collaboration initially contemplated by the parties under the November 2011 amendment described in Note 4, was expanded to encompass certain joint venture products for use in diesel and jet fuel on a worldwide basis and to provide a new structure for the research and development program and formation of the joint venture (the “Fuels JV”) to commercialize the products encompassed by the diesel and jet fuel research and development program (the “Program”).

Under the new agreements, the Company controls operations and execution of the Program subject to strategic and ultimate decision-making authority by a management committee composed of Company and Total representatives, and Total participates

34



in the ultimate Fuels JV, or receives rights to recover its investment if, at a series of decision points, it decides not to proceed with the project. The agreements contemplate that the parties would grant exclusive manufacturing and commercial licenses to the Fuels JV for the Fuels JV products when the Fuels JV is formed (subject to requirements for the Company to grant the license to Total in the event the Fuels JV is not formed because of a deadlock, followed by an election by the Company to sell to Total the assets it otherwise would have contributed to the Fuels JV, or earlier under certain circumstances), and that the Company would retain the right to make and sell products other than the Fuels JV products. Under the agreements, the Fuels JV licenses would be consistent with the principle that development, production and commercialization of the Fuels JV products in Brazil will remain with the Company unless Total elects, after formation of the Fuels JV, to have such business contributed to the Fuels JV. The agreements also provide that certain Fuels JV non-exclusive products that were contemplated by the November 2011 amendment to the collaboration agreement are no longer to be included in the Fuels JV, but that the parties will explore potential development and commercialization of such products at a later date.

The agreements contemplate that the research and development efforts under the Program may extend through 2016, with a series of “Go/No Go” decisions by Total through such date tied to funding by Total. Each funding tranche involves the issuance of senior unsecured convertible promissory notes by the Company to Total (see Note 6). The agreements provided for funding by Total of $15.0 million in July 2012 and an additional $15.0 million in September 2012 . (Such funding occurred in July and September as contemplated by the agreements.) Further, Total will, if it chooses to proceed with the Program, fund an additional $30.0 million in July 2013 , $10.85 million in July 2014 and $10.85 million in January 2015 . Thirty days following the earlier of the completion of the research and development program or December 31, 2016, Total has a final opportunity to decide whether or not to proceed with the Program.

At either of the decision points tied to the funding described above (in July 2013 or July 2014), if Total decides not to continue to fund the Program (or, at any funding date does not provide funding based on (i) the Company's failure to satisfy a closing condition under the purchase agreement for the notes, or (ii) Total's breach of the purchase agreement), the notes previously issued under the purchase agreement would remain outstanding and become payable by the Company at the maturity date in March 2017, the Program and associated agreements would terminate, all Company rights granted for use in farnesene-based diesel and farnesene-based jet fuel would revert to the Company, and no Fuels JV would be formed to commercialize the Fuels JV products.

In the final “Go/No Go” decision described above, Total may elect to (i) go forward with the full Program (diesel and jet fuel) (a “Go” decision), (ii) not continue its participation in the full Program, or (iii) go forward only with the jet fuel component of the Program, with the following outcomes:

For a “Go” decision by Total with respect to the whole Program, the parties would form the Fuels JV and the notes would be canceled.

For a “No-Go” decision by Total with respect to the whole Program, the consequences would be as described in the paragraph above regarding a decision by Total not to continue to fund the Program.

For a decision by Total to proceed with the jet fuel component of the Program and not the diesel component of the Program, 70% of the principal amount outstanding under the notes would remain outstanding and become payable by the Company and 30% of the outstanding principal of such notes would be canceled, the diesel product would no longer be included in the collaboration, the Fuels JV would not receive rights to products for use in diesel fuels, and the Fuels JV would be formed by the parties to commercialize products for use in jet fuels.

The agreements contemplate that the parties will finalize the structure for the Fuels JV in the future as set forth in the agreements and that the Fuels JV, if and when it is formed, would, subject to the conditions described below and absent other agreement, be owned equally ( 50% / 50% ) by the Company and Total. Under the agreements, the parties will, prior to the projected completion date, enter into a shareholders' agreement governing the Fuels JV, agree on the budget and business plan for the Fuels JV, and form the Fuels JV. In addition, following a final “Go” decision, the parties would enter into the Fuels JV license agreements, contribution agreements and other agreements required to establish the Fuels JV and enable it to operate.

Within 30 days prior to the final “Go” decision, Total may declare a “deadlock” if the parties fail to come to agreement on various matters relating to the formation of the Fuels JV, at which point Total may (i) elect to declare a “No-Go” decision, which has the consequences described above, or (ii) initiate a process whereby the fair value of the proposed Fuels JV would be determined and the Company would then have the option to: (x) elect to sell to Total the assets that the Company would have been required to contribute to the Fuels JV for an amount equal to 50% of such fair value; (y) proceed with the formation of the Fuels JV (accepting Total's position with respect to the funding requirement of the Fuels JV) and becoming a 50% owner of the Fuels JV; or (z) proceed with the formation of the Fuels JV (accepting Total's position with respect to the funding requirements of the Fuels JV), and then sell all or a portion of its 50% interest in the Fuels JV to Total for a price equal to the fair value multiplied by the

35



percentage ownership of the Fuels JV sold to Total.

The agreements provide that the Company would initially retain its ability to develop its diesel and jet fuel business in Brazil, and that Total has an option to require the Company to contribute its Brazil diesel and jet fuel business to the Fuels JV at a price determined pursuant to the agreements. Such option terminates if the Fuels JV is not formed or if Total subsequently buys out the Company's Fuels JV contribution. Furthermore, the option is limited to the jet fuel business if Total opts out of the diesel component of the Program as described above.

Under the agreements, Total has a right to participate in future equity or convertible debt financings of the Company through December 31, 2013 to preserve its pro rata ownership of the Company and thereafter in limited circumstances. The purchase price for the first $30.0 million of purchases under this pro rata right would be paid by cancellation of outstanding notes held by Total.

In connection with the purchase agreement and sale of the Notes, the Company entered into a registration rights agreement. Under such agreement, the Company is obligated to file a registration statement on Form S-3 with the SEC registering the resale of all of the shares of Company common stock issuable upon conversion of the notes within 20 days prior to the maturity date of the notes or within 30 days following optional conversion. In addition, the Company is obligated to have the registration statement declared effective within 70 - 100 days following the filing depending on whether the Company receives comments from the SEC. If the registration statement filing is delayed or the registration statement is not declared effective within the foregoing time frames, the Company is required to make certain monthly payments to the Total.
 
As a result of the July 2012 amendments, $23.3 million of payments received from Total that had been recorded as an advance from the collaborator were no longer contingently repayable and were recorded as a contract to perform research and development services, by reducing the capitalized deferred charge asset of $14.4 million and recording revenue of $8.9 million .

M&G Finanziaria Collaboration Agreement

In June 2010, the Company entered into a collaboration agreement with M&G Finanziaria S.R.L. (“M&G”) to incorporate Biofene as an ingredient in M&G's polyethylene terephthalate, or PET, resins to be incorporated into containers for food, beverages and other products. In April 2011, Amyris and M&G entered into an amended and restated collaboration agreement to amend certain portions of the original agreement entered into in June 2010 and adding Chemtex Italia S.R.L. and Chemtex International Inc. (both wholly owned subsidiaries of M&G) to the collaboration agreement. Under the terms of the amended agreement, the Company and Chemtex International Inc. will share the costs incurred associated with the PET collaboration on a 50 / 50 basis. In addition, the amended agreement expanded the collaboration arrangement between the Company and M&G to include a cellulosic feasibility study with each party bearing its own costs associated with such feasibility study. The collaboration agreement also establishes the terms under which M&G may purchase Biofene from the Company upon successful completion of product integration.

Firmenich Collaboration and Joint Development Agreements

In November 2010, the Company entered into collaboration and joint development agreements with Firmenich SA (“Firmenich”), a flavors and fragrances company based in Geneva, Switzerland. Under the agreement, Firmenich will fund technical development at the Company to produce an ingredient for the flavors and fragrances market. The Company will manufacture the ingredient and Firmenich will market it, and the parties will share in any resulting economic value. The agreement also grants worldwide exclusive flavors and fragrances commercialization rights to Firmenich for the ingredient. In addition, Firmenich has an option to collaborate with the Company to develop a second ingredient. In July 2011, the Company and Firmenich expanded their collaboration agreement to include a third ingredient. The collaboration and joint development agreements will continue in effect until the later of the expiration or termination of the development agreements or the supply agreements. The Company is also eligible to receive additional payments of up to $6.0 million upon the achievement of certain performance milestones towards which the Company will be required to make a contributory performance. These milestones are accounted for under the guidance in the FASB accounting standard update related to revenue recognition under the milestone method. The Company concluded that these milestones are substantive. For the nine months ended September 30, 2012 and 2011 , the Company recorded $4.3 million and $4.6 million , respectively, of revenue from the collaboration agreement with Firmenich. During the third quarter of 2012, the second milestone was reached and as a result $2.0 million was recognized as revenue in the period.

Michelin Collaboration Agreement

In September 2011, the Company entered into a collaboration agreement with Manufacture Francaise des Pneumatiques Michelin (“Michelin”). Under the terms of the collaboration agreement the Company and Michelin will collaborate on the development, production and worldwide commercialization of isoprene or isoprenol, generally for tire applications, using the

36



Company's technology. Under the agreement, Michelin has agreed to pay an upfront payment to the Company of $5.0 million , subject to a reimbursement provision under which the Company would have to repay $1.0 million if it fails to achieve specified future technical milestones. The agreement provides that, subject to achievement of technical milestones, Michelin can notify the Company of its desired date for initial delivery, and the parties will either collaborate to establish a production facility or use an existing Company facility for production. The agreement also includes a term sheet for a supply agreement that would be negotiated at the time the decision regarding production facilities is made. The agreement has an initial term that will expire upon the earlier of 42 months from the effective date and the completion of a development work plan. As of September 30, 2012 , the Company had recorded the upfront payment of $5.0 million from Michelin as deferred revenue.

Manufacturing Agreements

In 2010 and 2011, the Company entered into contract manufacturing agreements with Biomin do Brasil Nutricão Animal Ltda. (“Biomin”), Tate & Lyle Ingredients Americas, Inc. (“Tate & Lyle”), Antibióticos, S.A. (“Antibióticos”), Albemarle Corporation ("Albemarle"), and Glycotech (see Note 8) to utilize their manufacturing facilities to produce Amyris products.

Under the terms of these contract manufacturing agreements, the Company provided necessary equipment for the manufacturing of its products, over which the Company retained ownership. The Company also reimbursed the contract manufacturers for an aggregate of $13.8 million in expenditures related to the modification of their facilities. The Company recorded facility modification costs as other assets and amortized them as an offset against purchases of inventory. Certain of these contract manufacturing agreements also impose fixed purchase commitments on the Company, regardless of the production volumes.

Beginning in March 2012, the Company initiated a plan to shift a portion of its production capacity from the contract manufacturing facilities to a Company-owned plant that is currently under construction. As a result, the Company evaluated its contract manufacturing agreements and recorded a loss of $31.2 million related to the write-off of $10.0 million in facility modification costs and the recognition of $21.2 million of fixed purchase commitments in the three months ended March 31, 2012. The Company recognized an additional charge of $1.4 million associated with loss on fixed purchase commitments in the three months ended September 30, 2012. The Company computed the loss on facility modification costs and fixed purchase commitments using the same lower of cost or market approach that is used to value inventory. The computation of the loss on firm purchase commitments is subject to several estimates, including cost to complete and the ultimate selling price of any Company products manufactured at the relevant production facilities, and is therefore inherently uncertain. The Company also recorded a loss on write off of production assets of $5.5 million related to Amyris-owned production equipment at contract manufacturing facilities in the quarter ended March 31, 2012. The Company will continue to evaluate the potential for losses in future periods based on updated production and sales price assumptions.

Paraíso Bioenergia

In March 2011, the Company entered into a supply agreement with Paraíso Bioenergia. Under the agreement, the Company will construct fermentation and separation capacity to produce its products and Paraíso Bioenergia will supply sugar cane juice and other utilities. The Company will retain the full economic benefits enabled by the sale of Amyris farnesene-derived products over the lower of sugar or ethanol alternatives. In conjunction with the supply agreement, the Company also entered into an operating lease on real property owned by Paraíso Bioenergia. The real property is being used by the Company for the construction of an industrial facility (see Note 5).

Per the terms of the supply agreement, in the event that Paraíso is presented with an offer to sell or decides to sell the real property, the Company has the right of first refusal to acquire it. If the Company fails to exercise its right of first refusal the purchaser of the real property will need to comply with the specific obligations of Paraíso Bioenergia to the Company under the lease agreement.

Albemarle

In July 2011, the Company entered into a contract manufacturing agreement with Albemarle Corporation ("Albemarle"), which will provide toll manufacturing services at its facility in Orangeburg, South Carolina. Under this agreement, Albemarle will manufacture lubricant base oils from Biofene, which will be owned and distributed by the Company or a Company commercial partner. The initial term of this agreement is from July 31, 2011 through December 31, 2012. Albemarle is required to modify its facility, including installation and qualification of equipment and instruments necessary to perform the toll manufacturing services under the agreement. The Company reimbursed Albemarle $10.0 million for all capital expenditures related to the facility modification, which was accounted for as a prepaid asset. All equipment or facility modifications acquired or made by Albemarle will be owned by Albemarle, subject to Albemarle's obligation to transfer title to and ownership of certain assets to the Company

37



within 30 days after termination of the agreement, at the Company's discretion and sole expense. In March 2012 the Company recorded a loss of $10.0 million related to the write off of the facility modification costs, described above.

In addition, the Company was required to pay a one-time, non-refundable performance bonus of $5.0 million if Albemarle delivered to the Company a certain quantity of the lubricant base stock by December 31, 2011 or $2.0 million if Albemarle delivered the same quantity by January 31, 2012. Based on Albemarle's performance as of December 31, 2011, the Company concluded that Albemarle had earned the bonus and recorded a liability of $5.0 million as of September 30, 2012 . The bonus is payable in two payments: one payment of $2.5 million on September 30, 2012 and one payment of $2.5 million on March 31, 2013.
 
In February 2012, the Company entered into an amended and restated agreement with Albemarle, which superseded the original contract manufacturing agreement with Albemarle.  The term of the new agreement continues through December 31, 2019.  The agreement includes certain obligations for the Company to pay fixed costs totaling $7.5 million , of which $3.5 million and $4.0 million are payable in 2012 and 2014, respectively. In the three months ended March 31, 2012, the Company recorded a corresponding loss related to these fixed purchase commitments, as described above. In addition, fixed costs of $2.0 million per quarter are payable in 2013 if the Company exercises its option to have product manufactured in the facility in 2013.  The agreement also includes variable pricing during the contract term.

Supply Agreements

The Company has also entered into agreements to sell Biofene and its derivatives directly to various potential customers, including with Procter & Gamble Company ("P&G") for use in cleaning products, with M&G for use in plastics, with Kuraray Co., Ltd. ("Kuraray") for use in production of polymers, with Firmenich and Givaudan SA. ("Givaudan") for ingredients for the flavors and fragrances market, with Method Products, Inc. ("Method") for use in home and personal care products, and with Wilmar International Limited ("Wilmar") for use as a surfactant.

Soliance Agreements

In June 2010, the Company entered into an agreement with Soliance for the development and commercialization of Biofene-based squalane for use as an ingredient in cosmetics products. In December 2011, the Company and Soliance entered into an agreement and release to terminate the collaboration agreement and any other obligations with respect to the proposed joint venture. As part of the termination agreement the parties agreed that for a period commencing October 1, 2011 and ending on December 31, 2013, Soliance will be paid a commission of 10% of amounts received by the Company from Nikko Chemicals Co., Ltd. (“Nikko") on quantities of squalane sold by the Company to Nikko with respect to Nikko's committed minimum purchase obligation pursuant to a distribution agreement with Nikko. Concurrently with the execution of such termination agreement, the parties executed a distribution agreement, pursuant to which the Company appointed Soliance as its exclusive distributor to distribute the Company's squalane in the cosmetic market in the approved territory.

Nikko Chemicals

In August 2011, the Company entered into an agreement with Nikko, a private limited company in Japan, for the sales of renewable squalane to Nikko (commencing in September 2011 and continuing for two years through the end of December 2013).


10. Draths Corporation Acquisition

On October 6, 2011 (the Closing Date), the Company completed an acquisition of assets of Draths related to production of renewable chemicals. The acquisition was accounted for as a business combination. In connection with the acquisition, the Company issued 362,319 shares of common stock, of which 41,408 shares were held in escrow and paid $2.9 million in cash. In the quarter ended June 30, 2012, the Company recovered 5,402 shares of common stock from the escrow in connection with certain Draths indemnification obligations under the purchase agreement.

The components of the purchase price allocation for Draths are as follows:


38



Purchase Consideration:
 
 
(in thousands)
 
 
Fair value of common stock issued to Draths
 
$
7,000

Cash paid to Draths
 
2,934

     Total purchase consideration
 
$
9,934


Allocation of Purchase Price:
 
 
(in thousands)
 
 
Property and Equipment
 
$
713

Other
 
101

In-process research and development
 
8,560

Goodwill
 
560

     Total purchase consideration
 
$
9,934

The Company allocated $8.6 million of the purchase price of Draths to acquired IPR&D. This amount represents management's valuation of the fair value of assets acquired at the date of the acquisition. Management used the income approach to determine the estimated fair values of acquired IPR&D, applying a risk adjusted discount rate of 30% to the development project's cash flows. The discounted cash flow model applies probability weighting factors, based on estimates of successful product development and commercialization, to estimated future net cash flows resulting from projected revenues and related costs. These success rates take into account the stages of completion and the risks surrounding successful development and commercialization of the underlying products such as estimates of revenues and operating profits related to the IPR&D considering its stage of development; the time and resources needed to complete the development; the life of the potential commercialized product and associated risks, including the inherent difficulties and uncertainties in developing a product.
     
Goodwill totaling $0.6 million represents the excess of the purchase price over the fair value of tangible and identifiable intangible assets acquired and is due primarily to synergies expected from combining the new genetic pathway with the Company's existing platform to accelerate development to get the technology to market sooner leading to increased market penetration from future products and customers.

The Draths business acquisition was a taxable transaction. For federal and state tax purposes, the above in-process research and development and goodwill is amortized over a 15-year period. The Company has determined that there are no significant differences in the tax basis of assets and the basis for financial reporting purposes. In addition, the business combination did not have any impact on the Company's deferred tax balance, net of the full valuation allowance, or to uncertain tax positions, at the acquisition date.

The Company applies the applicable accounting principles set forth in the U.S. Financial Accounting Standards Board's Accounting Standards Codification to its intangible assets (including goodwill), which prohibits the amortization of intangible assets with indefinite useful lives and requires that these assets be reviewed for impairment at least annually. There are several methods that can be used to determine the estimated fair value of the IPR&D acquired in a business combination. The Company has used the "income method," which applies a probability weighting that considers the risk of development and commercialization, to the estimated future net cash flows that are derived from projected sales revenues and estimated costs. These projections are based on factors such as relevant market size, pricing of similar products, and expected industry trends. The estimated future net cash flows are then discounted to the present value using an appropriate discount rate. These assets are treated as indefinite-lived intangible assets until completion or abandonment of the projects, at which time the assets will be amortized over the remaining useful life or written off, as appropriate. If the carrying amount of the assets is greater than the measures of fair value, impairment is considered to have occurred and a write-down of the asset is recorded. Any finding that the value of its intangible assets has been impaired would require the Company to write-down the impaired portion, which could reduce the value of its assets and reduce its net income for the year in which the related impairment charges occur.  
      

11. Stockholders’ Equity

Private Placement

In May 2012, the Company completed a private placement of its common stock of 1,736,100 shares of common stock at a

39



price of $2.36 for aggregate proceeds of $4.1 million .

In February 2012, the Company completed a private placement of its common stock of 10,160,325 shares of common stock at a price of $5.78 for aggregate proceeds of $58.7 million . In connection with this private placement, the Company entered into an agreement with an investor to purchase additional shares of Common Stock for an additional $15.0 million upon satisfaction by the Company of criteria associated with the commissioning of the Company's Paraíso Bioenergia production plant in Brazil by March 2013. Additionally, such agreement granted certain investors Board designation rights and certain rights of first investment with respect to future issuances of the Company's securities.

Common Stock

Pursuant to the Company’s amended and restated certificate of incorporation, the Company is authorized to issue 100,000,000 shares of common stock. Holders of the Company’s common stock are entitled to dividends as and when declared by the Board of Directors, subject to the rights of holders of all classes of stock outstanding having priority rights as to dividends. There have been no dividends declared to date. The holder of each share of common stock is entitled to one vote.

Preferred Stock

Pursuant to the Company’s amended and restated certificate of incorporation, the Company is authorized to issue 5,000,000 shares of preferred stock. The Board of Directors has the authority, without action by its stockholders, to designate and issue shares of preferred stock in one or more series and to fix the rights, preferences, privileges and restrictions thereof. Prior to the closing of the Company’s IPO, the Company had four series of convertible preferred stock outstanding, including Series D preferred stock issued to Total (see Note 9). As of September 30, 2012 and December 31, 2011 , the Company had zero shares of convertible preferred stock outstanding.

Common Stock Warrants

During the period from January 1, 2008 to September 30, 2010, the Company issued 182,405 warrants in connection with placement agent fees associated with its preferred stock issuance, capital and operating lease agreements and consulting services. Upon the closing of the Company’s IPO on September 30, 2010, these outstanding convertible preferred stock warrants were automatically converted into common stock warrants to purchase 195,604 shares of common stock. In addition, the fair value of the convertible preferred stock warrants as of September 30, 2010, estimated to be $2.3 million using the Black-Scholes option pricing model, was reclassified to additional paid in capital.

In December 2011, in connection with a capital lease agreement, the Company issued a warrant to purchase 21,087 shares of the Company's common stock at an exercise price of $10.67 a share. The Company estimated the fair value of these warrants as of the issuance date to be $193,000 and was recorded as other assets and amortized subsequently over the term of the lease. The fair value was based on the contractual term of the warrants of 10 years, risk free interest rate of 2.0% , expected volatility of 86% and zero expected dividend yield. This warrant remains unexercised and outstanding as of September 30, 2012 .
Each of these warrants included a cashless exercise provision which permitted the holder of the warrant to elect to exercise the warrant without paying the cash exercise price, and receive a number of shares determined by multiplying (i) the number of shares for which the warrant is being exercised by (ii) the difference between the fair market value of the stock on the date of exercise and the warrant exercise price, and dividing such by (iii) the fair market value of the stock on the date of exercise. During the nine months ended September 30, 2012 and 2011 , warrants were exercised with respect to zero and 190,468 shares, respectively through the cashless exercise provision and 77,087 shares of common stock were issued after deducting the shares to cover the cashless exercises. There were no warrants exercised during the three months ended September 30, 2012 and 2011 .

As of September 30, 2012 and December 31, 2011 , the Company had the following unexercised common stock warrants outstanding:
 
 
Expiration Date
 
Exercise
Price per Share
 
Shares as of
Underlying Stock
 
 
 
September 30, 2012
 
December 31, 2011
Common Stock
 
1/31/2018
 
$
24.88

 

 
2,884

Common Stock
 
9/23/2018
 
$
25.26

 

 
2,252

Common Stock
 
12/23/2021
 
$
10.67

 
21,087

 
21,087

Total
 
 
 
 
 
21,087

 
26,223



40




12. Stock-Based Compensation Plans

2010 Equity Incentive Plan

The Company's 2010 Equity Incentive Plan (“2010 Equity Plan”) became effective on September 28, 2010 and will terminate in 2020. Pursuant to the 2010 Equity Plan, any shares of the Company’s common stock (i) issued upon exercise of stock options granted under the Company's 2005 Stock Option/Stock Issuance Plan (the "2005 Plan")that cease to be subject to such option and (ii) issued under the 2005 Plan that are forfeited or repurchased by the Company at the original purchase price will become part of the 2010 Equity Plan. Subsequent to the effective date of the 2010 Equity Plan, an additional 737,807 shares that were forfeited under the 2005 Plan were added to the shares reserved for issuance under the 2010 Equity Plan.

The number of shares reserved for issuance under the 2010 Equity Plan increase automatically on January 1 st of each year starting with January 1, 2011, by a number of shares equal to 5.0% percent of the Company’s total outstanding shares as of the immediately preceding December 31 st . The Company’s Board of Directors or the Leadership Development and Compensation Committee of the Board of Directors is able to reduce the amount of the increase in any particular year. The 2010 Equity Plan provides for the granting of common stock options, restricted stock awards, stock bonuses, stock appreciation rights, restricted stock units and performance awards. It allows for time-based or performance-based vesting for the awards. Options granted under the 2010 Equity Plan may be either incentive stock options ("ISOs") or non-statutory stock options ("NSOs"). ISOs may be granted only to Company employees (including officers and directors who are also employees). NSOs may be granted to Company employees, non-employee directors and consultants. The Company will be able to issue no more than 30,000,000 shares pursuant to the grant of ISOs under the 2010 Equity Plan. Options under the 2010 Equity Plan may be granted for periods of up to ten years. All options issued to date have had a ten year life. Under the plan, the exercise price of any ISOs and NSOs may not be less than 100% of the fair market value of the shares on the date of grant. The exercise price of any ISOs and NSOs granted to a 10% stockholder may not be less than 110% of the fair value of the underlying stock on the date of grant. The options granted to date generally vest over four to five years.

As of September 30, 2012 , options to purchase 5,031,057 shares of our common stock granted from the 2010 Equity Plan were outstanding and 2,508,896 shares of the Company’s common stock remained available for future awards that may be granted from the 2010 Equity Plan. The options outstanding as of September 30, 2012 had a weighted-average exercise price of approximately $11.24 per share.

2005 Stock Option/Stock Issuance Plan

In 2005, the Company established its 2005 Plan which provided for the granting of common stock options, restricted stock units, restricted stock and stock purchase rights awards to employees and consultants of the Company. The 2005 Plan allowed for time-based or performance-based vesting for the awards. Options granted under the 2005 Plan were ISOs or NSOs. ISOs were granted only to Company employees (including officers and directors who are also employees). NSOs were granted to Company employees, non-employee directors, and consultants.

All options issued under the 2005 Plan have had a ten year life. The exercise prices of ISOs and NSOs granted under the 2005 Plan were not less than 100% of the estimated fair value of the shares on the date of grant, as determined by the Board of Directors. The exercise price of an ISO and NSO granted to a 10% stockholder could not be less than 110% of the estimated fair value of the underlying stock on the date of grant as determined by the Board of Directors. The options generally vested over five years.

As of September 30, 2012 , options to purchase 3,254,343 shares of the Company’s common stock granted from the 2005 Stock Option/Stock Issuance Plan remained outstanding and, as a result of the adoption of the 2010 Equity Incentive Plan discussed above, zero shares of the Company’s common stock remained available for issuance under the 2005 Plan. The options outstanding under the 2005 Plan as of September 30, 2012 had a weighted-average exercise price of approximately $7.83 per share.

No income tax benefit has been recognized relating to stock-based compensation expense and no tax benefits have been realized from exercised stock options or release of restricted stock units.

2010 Employee Stock Purchase Plan

The 2010 Employee Stock Purchase Plan (the “2010 ESPP”) became effective on September 28, 2010. The 2010 ESPP is designed to enable eligible employees to purchase shares of the Company’s common stock at a discount. Each offering period is for one year and consists of two six-month purchase periods. Each twelve-month offering period generally commences on May 16 th

41



and November 16 th , each consisting of two six-month purchase periods. The purchase price for shares of common stock under the 2010 ESPP is the lesser of 85% of the fair market value of the Company’s common stock on the first day of the applicable offering period or the last day of each purchase period. A total of 168,627 shares of common stock were initially reserved for future issuance under the 2010 Employee Stock Purchase Plan. During the first eight years of the life of the 2010 ESPP, the number of shares reserved for issuance increases automatically on January 1 st of each year, starting with January 1, 2011, by a number of shares equal to 1% of the Company’s total outstanding shares as of the immediately preceding December 31 st . Pursuant to the automatic increase provision, an additional 459,325 shares were reserved for issuance during the nine months ended September 30, 2012 for a cumulative total of 897,799 additional shares reserved for issuance under the automatic increase provision. The Company’s Board of Directors or the Leadership Development and Compensation Committee of the Board of Directors is able to reduce the amount of the increase in any particular year. No more than 10,000,000 shares of the Company’s common stock may be issued under the 2010 ESPP and no other shares may be added to this plan without the approval of the Company’s stockholders.

During the three months ended September 30, 2012 and 2011 , no shares of common stock were purchased under the 2010 ESPP and during the nine months ended September 30, 2012 and 2011 , 454,010 and zero shares of common stock, respectively, were purchased under this stock purchase plan. At September 30, 2012 , 311,857 shares of the Company’s common stock remained available for issuance under the 2010 ESPP.
 
Stock Option Activity

The Company’s stock option activity and related information for the nine months ended September 30, 2012 was as follows:
 
 
 
 
Number
Outstanding
 
Weighted -
Average
Exercise
Price
 
Weighted -
Average
Remaining
Contractual
Life (Years)
 
Aggregate
Intrinsic
Value
 
 
 
 
 
 
 
 
 
(in thousands)
Outstanding - December 31, 2011
 
8,377,016

 
$
14.05

 
7.9

 
$
29,127

 
Options granted
 
2,663,763

 
$
3.69

 

 

 
Options exercised
 
(856,114
)
 
$
0.72

 

 

 
Options cancelled
 
(1,839,265
)
 
$
16.45

 

 

Outstanding - September 30, 2012
 
8,345,400

 
$
9.85

 
7.5

 
$
1,083

 
 
 
 
 
 
 
 
 
Vested and expected to vest after September 30, 2012
 
7,745,694

 
$
9.90

 
7.3

 
$
1,023

Exercisable at September 30, 2012
 
3,841,181

 
$
9.90

 
5.9

 
$
695



The aggregate intrinsic value of options exercised under all option plans was $2.0 million and $5.2 million for the three months ended September 30, 2012 and 2011 , respectively, and $2.7 million and $27.4 million for the nine months ended September 30, 2012 and 2011 , respectively, determined as of the date of option exercise.

The Company’s restricted stock units ("RSUs") and restricted stock activity and related information for the nine months ended September 30, 2012 was as follows:

  
 
RSUs
 
Weighted Average Grant-Date Fair Value
 
Weighted Average Remaining Contractual Life (Years)
Outstanding - December 31, 2011
375,189

 
$
29.84

 
1.4

 Awarded
 
1,964,000

 
$
3.69

 
 
 Vested
 
(415,792
)
 
$
13.47

 
 
 Forfeited
 
(210,498
)
 
$
15.34

 
 
Outstanding - September 30, 2012
1,712,899

 
$
5.61

 
1.4

Expected to vest after September 30, 2012
1,482,729

 
$
5.61

 
1.4


RSUs are converted into common stock upon vesting. Upon the vesting of RSUs, the Company primarily uses the net share

42



settlement approach, where a portion of the shares are withheld and cancelled as settlement of statutory employee withholding taxes, which decreases the shares issued to the employee by a corresponding value.

The following table summarizes information about stock options outstanding as of September 30, 2012 :
 
 
Options Outstanding
 
Options Exercisable
Exercise Price
Number of Options
 
Weighted -
Average
Remaining
Contractual Life
(Years)
 
Weighted Average Exercise Price
 
Number of Options
 
Weighted Average Exercise Price
$0.10—$3.23
948,407

 
7.9

 
$
2.30

 
288,234

 
$
1.03

$3.55—$3.55
54,000

 
9.8

 
$
3.55

 

 
$

$3.86—$3.86
1,480,113

 
9.1

 
$
3.86

 
218,480

 
$
3.86

$3.93—$3.93
1,200,343

 
4.2

 
$
3.93

 
1,115,829

 
$
3.93

$4.06—$9.32
1,411,280

 
7.0

 
$
6.40

 
756,536

 
$
6.46

$10.44—$14.28
330,589

 
7.4

 
$
12.60

 
152,801

 
$
13.99

$16.00—$16.00
1,221,900

 
8.3

 
$
16.00

 
487,325

 
$
16.00

$16.50—$20.41
1,075,373

 
7.7

 
$
18.55

 
533,417

 
$
18.70

$24.20—$27.13
543,395

 
7.9

 
$
26.34

 
248,559

 
$
26.12

$30.17—$30.17
80,000

 
8.5

 
$
30.17

 
40,000

 
$
30.17

$0.10—$30.17
8,345,400

 
7.5

 
$
9.85

 
3,841,181

 
$
9.90

 
Common Stock Subject to Repurchase

Historically under the 2005 Plan, the Company allowed employees to exercise options prior to vesting. The Company has the right to repurchase at the original purchase price any unvested (but issued) common shares upon termination of service of an employee. The consideration received for an early exercise of an option is considered to be a deposit of the exercise price and the related dollar amount is recorded as a liability. The shares and liability are reclassified into equity on a ratable basis as the award vests. The Company recorded a liability in accrued expenses of $1,179 and $30,000 , respectively, relating to options for 301 and 7,929 shares of common stock that were exercised and unvested as of September 30, 2012 and December 31, 2011 , respectively. These shares were subject to a repurchase right held by the Company and are included in issued and outstanding shares as of September 30, 2012 and December 31, 2011 , respectively.

Stock-Based Compensation Expense

Stock-based compensation expense related to options and restricted stock units granted to employees and non-employees was allocated to research and development expense and sales, general and administrative expense as follows (in thousands):

 
Three Months Ended September 30,
 
Nine Months Ended September 30,
 
 
2012
 
2011
 
2012
 
2011
Research and development
$
1,450

 
$
1,711

 
$
4,521

 
$
4,697

Sales, general and administrative
4,515

 
5,162

 
16,879

 
14,139

Total stock-based compensation expense
$
5,965

 
$
6,873

 
$
21,400

 
$
18,836


Employee Stock–Based Compensation

During the three months ended September 30, 2012 and 2011 , the Company granted options to purchase 431,860 and 228,750 shares of its common stock, respectively, to employees with weighted average grant date fair values of $2.48 and $14.48  per share, respectively. During the nine months ended September 30, 2012 and 2011 , the Company granted options to purchase 2,660,763 and 2,478,125 shares of its common stock, respectively, to employees, with weighted average grant date fair values of $2.40 and $19.21  per share, respectively. As of September 30, 2012 and December 31, 2011 , there were unrecognized compensation costs of $41.8 million and $54.7 million , respectively, related to outstanding employee stock options. The Company expects to recognize those costs over a weighted average period of 3 years as of September 30, 2012 . Future option grants will increase the amount of compensation expense to be recorded in these periods.


43



In August 2012, the Company's CEO exercised outstanding options to purchase 668,730 shares of the Company's common stock and sold the shares to certain members of the Company's Board of Directors or their affiliates through a private sale at a price of $3.70 , which was greater than the fair market value of the stock at the date of sale. During the three and nine months ended September 30, 2012 , the Company recorded $388,000 in stock-based compensation expense as an excess of the sale price over the fair market value of shares in this transaction.

During the three months ended September 30, 2012 and 2011 , 127,000 and 21,000 RSUs, respectively, were granted to employees with a weighted average service-inception date fair value of $3.95 and $24.50 , respectively. During the nine months ended September 30, 2012 and 2011 , 1,964,000 and 352,301 RSUs, respectively, were granted to employees with a weighted average service-inception date fair value of $3.69 and $29.85 per unit, respectively. The Company recognized a total of $1.1 million and $0.9 million , respectively, for the three months ended September 30, 2012 and 2011 and $4.7 million and $2.7 million , respectively, for the nine months ended September 30, 2012 and 2011 in stock-based compensation expense for RSUs granted to employees. As of September 30, 2012 and December 31, 2011 , there were unrecognized compensation costs of $7.5 million and $6.0 million , respectively, related to these RSUs.

The Company also recognized stock-based compensation expense related to its 2010 ESPP of $105,000 and $518,000 , respectively, during the three months ended September 30, 2012 and 2011 , and $701,000 and $1,427,000 , respectively, during the nine months ended September 30, 2012 and 2011 .

Compensation expense was recorded for stock-based awards granted to employees based on the grant date estimated fair value (in thousands):
 
 
Three Months Ended September 30,
 
Nine Months Ended September 30,
 
2012
 
2011
 
2012
 
2011
Research and development
$
1,444

 
$
1,703

 
$
4,511

 
$
4,663

Sales, general and administrative
4,496

 
4,883

 
16,771

 
13,274

Total stock-based compensation expense
$
5,940

 
$
6,586

 
$
21,282

 
$
17,937


Employee stock-based compensation expense recognized for the three and nine months ended September 30, 2012 included zero and $811,000 , respectively related to option modifications. In the second quarter of 2012, as part of separation agreements with certain former senior employees, the Company agreed to accelerate the vesting of options for 698,886 shares of common stock and extend the exercise period for certain grants. The stock-based compensation expense above includes the impact of a repricing of stock options in June 2012 under which certain non-executive employees received a one-time reduction in the exercise price for such options with exercise prices per share higher than $24.00 held by U.S. employees of Amyris and the new exercise price for such options was $16.00 , our initial public offering price. The total amount of the stock-based charge associated with repricing was immaterial to the consolidated financial statements.

In the quarter ended June 30, 2011, the Company commenced sales of farnesene-derived products which were produced by contracted third parties. Accordingly, the Company did not have any dedicated production headcount so there is no stock-based compensation expense recorded in cost of products sold.
 
Stock-based compensation cost for RSUs is measured based on the closing fair market value of the Company's common stock on the date of grant. Stock-based compensation cost for stock options and employee stock purchase plan rights is estimated at the grant date and offering date, respectively, based on the fair-value using the Black-Scholes option pricing model. The fair value of employee stock options is being amortized on a straight-line basis over the requisite service period of the awards. The fair value of employee stock options was estimated using the following weighted-average assumptions:
 
 
Three Months Ended September 30,
 
Nine Months Ended September 30,
 
2012
 
2011
 
2012
 
2011
Expected dividend yield
%
 
%
 
%
 
%
Risk-free interest rate
0.9
%
 
1.3
%
 
1.1
%
 
2.4
%
Expected term (in years)
5.9

 
5.1

 
6.0

 
5.8

Expected volatility
79
%
 
85
%
 
76
%
 
86
%

Expected Dividend Yield —The Company has never paid dividends and does not expect to pay dividends.


44



Risk-Free Interest Rate —The risk-free interest rate was based on the market yield currently available on United States Treasury securities with maturities approximately equal to the option’s expected term.

Expected Term —The expected term represents the period that the Company’s stock-based awards are expected to be outstanding. The Company’s assumptions about the expected term have been based on that of companies that have similar industry, life cycle, revenue, and market capitalization and the historical data on employee exercises.

Expected Volatility —The expected volatility is based on a combination of historical volatility for the Company's stock and the historical stock volatilities of several of the Company’s publicly listed comparable companies over a period equal to the expected terms of the options, as the Company does not have a long trading history.

Fair Value of Common Stock — Prior to the IPO, the fair value of the shares of common stock underlying the stock options was determined by the Board of Directors. Because there was no public market for the Company’s common stock, the Board of Directors determined the fair value of the common stock at the time of grant of the option by considering a number of objective and subjective factors including valuation of comparable companies, sales of convertible preferred stock to unrelated third parties, operating and financial performance, the lack of liquidity of capital stock and general and industry specific economic outlook, amongst other factors. The Company’s common stock started trading in the NASDAQ Global Market under ticker symbol AMRS on September 28, 2010. Consequently, after the IPO, the fair value of the shares of common stock underlying the stock options is the closing price on the option grant date.

Forfeiture Rate —The Company estimates its forfeiture rate based on an analysis of its actual forfeitures and will continue to evaluate the adequacy of the forfeiture rate based on actual forfeiture experience, analysis of employee turnover behavior, and other factors. The impact from a forfeiture rate adjustment will be recognized in full in the period of adjustment, and if the actual number of future forfeitures differs from that estimated by the Company, the Company may be required to record adjustments to stock-based compensation expense in future periods.

Each of the inputs discussed above is subjective and generally requires significant management and director judgment to determine.

Nonemployee Stock–Based Compensation

During the three months ended September 30, 2012 and 2011 , the Company granted zero and 15,000 options, respectively, and for the nine months ended September 30, 2012 and 2011 3,000 and 15,000 options, respectively, to purchase shares of common stock to nonemployees in exchange for services. Stock-based compensation expense of $21,000 and $227,000 was recorded for the three months ended September 30, 2012 and 2011 , respectively, and $74,000 and $699,000 for the nine months ended September 30, 2012 and 2011 , respectively, for options granted to nonemployees. The nonemployee options were valued using the Black-Scholes option pricing model.

During the three months ended September 30, 2012 and 2011 , zero and 2,855 restricted stock units, respectively, were granted to nonemployees. Stock-based compensation expense of $4,000 and $61,000 respectively, was recorded for the three months ended September 30, 2012 and 2011 . During the nine months ended September 30, 2012 and 2011 , zero and 32,855 restricted stock units, respectively, were granted to nonemployees and a total of $45,000 and $200,000 respectively, in stock-based compensation expense was recognized by the Company.

The fair value of nonemployee stock options was estimated using the following weighted-average assumptions:
 
 
Three Months Ended September 30,
 
Nine Months Ended September 30,
 
2012
 
2011
 
2012
 
2011
Expected dividend yield
%
 
%
 
%
 
%
Risk-free interest rate
1.3
%
 
1.5
%
 
1.5
%
 
2.3
%
Expected term (in years)
6.9

 
7.8

 
7.1

 
7.9

Expected volatility
79
%
 
85
%
 
77
%
 
86
%
 
13. Employee Benefit Plan

The Company established a 401(k) Plan to provide tax deferred salary deductions for all eligible employees. Participants may make voluntary contributions to the 401(k) Plan up to 90% of their eligible compensation, limited by certain Internal Revenue

45



Service restrictions. The Company does not match employee contributions.

14. Related Party Transactions

The Company has entered into a license agreement with University of California, Berkeley. A co-founder and advisor to the Company is a professor at the University of California, Berkeley. The Company paid the advisor zero during the nine months ended September 30, 2012 and 2011 , respectively.

During 2008, the Company entered into an agreement with a venture capital group to provide strategic advisory services to Amyris and its then majority owned subsidiary, Amyris Brasil. One of its former directors is also a member of the Company’s Board of Directors. Under the agreement, the Company issued options to the venture capital group, which vest and become exercisable based on the service of the former director of the group on the Company's Board of Directors (see Note 12).

On June 21, 2010 the Company entered into agreements with Total relating to the Company’s Series D preferred stock and collaboration for the research, development, production and commercialization of chemical and/or fuel products (see Note 9).

In November 2011, the Company and Total entered into an amendment of their Technology License, Development, Research and Collaboration Agreement (see Note 4).

On October 6, 2011, the Company completed a business combination with Draths. In connection with the acquisition, the Company issued 362,319 shares of the Company's common stock, of which 41,408 shares were held in escrow and paid $2.9 million in cash. In the quarter ended June 30, 2012, the Company recovered 5,402 shares of common stock from the escrow in connection with certain Draths indemnification obligations under the purchase agreement. One of the Company's board members was also on the board of Draths.

In February 2012, the Company completed a private placement of 10,160,325 shares of common stock at a price of $5.78 per share for aggregate proceeds of $58.7 million pursuant to a securities purchase agreement, among the Company and existing certain investors, including Total and Maxwell (Mauritius) Pte Ltd, each a beneficial owner of more than 5% of our existing common stock at the time of the transaction. In addition, members of the Company's Board of Directors and certain parties related to such directors participated in the offering.

In May 2012, the Company completed a private placement of 1,736,100 shares of common stock at a price of $2.36 for aggregate proceeds of $4.1 million pursuant to a series of Common Stock Purchase Agreements, among the Company and members of the Company's Board of Directors and certain parties related to such directors.

In July 2012 , the Company entered into various agreements with Total relating to the Program (see Note 9).


15. Income Taxes

For the three months ended September 30, 2012 and 2011 , the Company recorded a provision for income taxes of $260,000 and $474,000 , respectively, and for the nine months ended September 30, 2012 and 2011 a provision for income taxes of $753,000 and $299,000 , respectively. The provision for incomes for three and nine months ended September 30, 2012 consisted of an accrual of Brazilian withholding tax on an intercompany interest liability. The provision for income taxes in the three months ended September 30, 2011 of $474,000 was for the accrual of Brazilian withholding tax on the intercompany interest liability while the provision for income taxes of $299,000 for the nine months ended September 30, 2011 consisted of this $474,000 accrual partially offset by $175,000 benefit from income taxes resulting from valuation allowance adjustments due to an increase in currency translation adjustments classified as other comprehensive losses. Other than the above mentioned provision for income tax, no additional provision for income taxes has been made, net of the valuation allowance, due to cumulative losses since the commencement of operations.

The Company is currently under audit by the US Internal Revenue Service for tax year 2008. As of September 30, 2012 , the Company has received Form 4549-A, Income Tax Discrepancy Adjustments (Examination No Change Report) which concluded that there were no adjustments resulting from the audit by the US Internal Revenue Service for the tax year 2008.  As of September 30, 2012 , the Company has not yet received the Area Director's final approval of the report. Therefore, the tax year 2008 remains open.



46



16. Reporting Segments

The chief operating decision maker for the Company is the chief executive officer. The chief executive officer reviews financial information presented on a consolidated basis, accompanied by information about revenue by geographic region, for purposes of allocating resources and evaluating financial performance. The Company has one business activity comprised of development and sales of fuels and farnesene-derived products and there are no segment managers who are held accountable for operations, operating results or plans for levels or components below the consolidated unit level. Accordingly, the Company has determined that it has a single reportable segment and operating unit structure.

Revenues by geography are based on the location of the customer. The following tables set forth revenue and long-lived assets by geographic area (in thousands):

Revenues
 
Three Months Ended September 30,
 
Nine Months Ended September 30,
 
2012
 
2011
 
2012
 
2011
United States
$
3,905

 
$
35,441

 
$
46,807

 
$
100,799

Brazil
1,053

 
6

 
2,741

 
6

Europe
12,452

 
829

 
15,785

 
4,647

Asia
1,698

 

 
2,507

 

Total
$
19,108

 
$
36,276

 
$
67,840

 
$
105,452




Long-Lived Assets
 
September 30, 2012
 
December 31, 2011
 
United States
$
73,536

 
$
76,108

Brazil
89,190

 
48,240

Europe
1,977

 
3,753

Total
$
164,703

 
$
128,101



17. Subsequent Events

On October 1, 2012, the Company paid the $2.5 million first installment of its non-refundable performance bonus liability to Albemarle (see Note 9).

On October 18, 2012, the Company and Antibióticos entered into a Termination Agreement whereby the Company agreed to pay Antibióticos €3.5 million (approximately US$4.5 million as of September 30, 2012 ), which represents all of the Company's outstanding financial obligations under a manufacturing agreement entered into by both parties in 2011. The payment of €3.5 million (approximately US$4.5 million as of September 30, 2012 ) will be paid in four installments with the remaining three payments scheduled to be paid in the fourth quarter of 2012. As of September 30, 2012 , the Company paid the first installment of €250,000 (approximately $0.3 million as of September 30, 2012 ) and had accrued a liability of US$4.3 million for the remaining obligation on this termination agreement.

47




ITEM 2. MANAGEMENT’S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION AND RESULTS OF OPERATIONS

Forward-Looking Statements

The following discussion and analysis should be read in conjunction with our condensed consolidated financial statements and the related notes that appear elsewhere in this Form 10-Q. These discussions contain forward-looking statements reflecting our current expectations that involve risks and uncertainties which are subject to safe harbors under the Securities Act of 1933, as amended, or the Securities Act, and the Securities Exchange Act of 1934, as amended, or the Exchange Act. These forward-looking statements include, but are not limited to, statements concerning our strategy, future production capacity and other aspects of our future operations, ability to improve our production efficiencies, future financial position, future revenues, projected costs, expectations regarding demand and acceptance for our technologies, growth opportunities and trends in the market in which we operate, prospects and plans and objectives of management. The words “anticipates,” “believes,” “estimates,” “expects,” “intends,” “may,” “plans,” “projects,” “will,” “would” and similar expressions are intended to identify forward-looking statements, although not all forward-looking statements contain these identifying words. We may not actually achieve the plans, intentions or expectations disclosed in our forward-looking statements and you should not place undue reliance on our forward-looking statements. These forward-looking statements involve risks and uncertainties that could cause our actual results to differ materially from those in the forward-looking statements, including, without limitation, the risks set forth in Part II, Item 1A, “Risk Factors,” in this Quarterly Report on Form 10-Q and in our other filings with the Securities and Exchange Commission. We do not assume any obligation to update any forward-looking statements.

Trademarks

Amyris®, the Amyris logo, Biofene® and No Compromise® are trademarks or registered trademarks of Amyris, Inc. This report also contains trademarks and trade names of other businesses that are the property of their respective holders.

Overview

We are building an integrated renewable products company to provide sustainable alternatives to a broad range of petroleum-sourced products used in specialty chemical and transportation fuel markets worldwide. We do this by applying our industrial synthetic biology technology platform to modify microorganisms, primarily yeast, to function as living factories in established fermentation processes to convert plant-sourced sugars into a variety of hydrocarbon molecules that can serve as flexible building blocks to be used in a wide range of products.

We were incorporated in 2003 and commenced research, development, marketing and administrative activities in 2005. To further develop our business we have established two subsidiaries, Amyris Brasil, which oversees the establishment and expansion of our production in Brazil, and Amyris Fuels. Through the third quarter of 2012, we also conducted an ethanol and reformulated ethanol-blended gasoline business through Amyris Fuels, but have, as of September 30, 2012, transitioned out of that business.

While our technology enables us to design yeast and other microorganisms to produce many different kinds of molecules, our current priority is the commercialization and production of Biofene, and its derivatives for sale in a range of specialty chemical applications within the following six identified markets: cosmetics, lubricants, flavors and fragrances, polymers and plastic additives, home and personal care products and transportation fuels.

In April 2010, we entered into a definitive agreement with Usina São Martinho to establish a joint venture entity for construction and operation of a large-scale production facility in Brazil. In March 2011, we entered into an agreement with Paraíso Bioenergia (Paraíso), under which we are designing and building a fermentation and separation plant on leased space at the Paraíso Bioenergia facility and Paraíso will supply sugar cane juice and other utilities. The manufacturing facility at Paraíso Bioenergia is our initial principal focus for production capacity. Based on our shifting manufacturing priorities and uncertainty regarding financing availability, we cannot currently predict, when or if, our facility at Usina São Martinho will be completed or commence commercial operations.

Total Relationship

In June 2010, we entered into a collaboration agreement with Total. This agreement provided for joint collaboration on the development of products through the use of our synthetic biology platform. In connection with this agreement, Total invested $133.2 million in our equity. At the end of the second quarter of 2010, we recorded a deferred charge asset of $27.9 million associated with the Total investment. This deferred charge asset resulted from the difference between a third party valuation of

48



our stock and the price paid by Total. This deferred charge asset was to be offset against future revenue earned under arrangements with Total. As of September 30, 2012 , we recognized a cumulative reduction of $27.9 million against the deferred charge asset based on collaboration services provided by us and, the settlement of the contingently repayable advance from Total pursuant to an amendment of the collaboration agreement (as described below).

In November 2011, we entered into an amendment of the collaboration agreement with Total with respect to development and commercialization of Biofene for diesel. This represented an expansion of the initial collaboration that the parties established in 2010, and established a global, exclusive collaboration for the development of Biofene for diesel and a framework for the creation of a joint venture to manufacture and commercialize Biofene for diesel. In addition, a limited number of other potential products were subject to development for the joint venture on a non-exclusive basis.

In July 2012, we entered into a further amendment of the collaboration agreement with Total that expanded Total's investment in the Biofene collaboration, incorporated the development of certain joint venture products for use in diesel and jet fuel into the scope of the collaboration, and changed the structure of the funding from Total to include a convertible debt mechanism. Under the new agreements, we issued senior unsecured convertible notes to Total for an aggregate of $30.0 million in new cash in the third quarter of 2012. Further funding will be triggered by Total at annual decision points in mid-2013 and 2014. Upon completion of the research and development program, we and Total would form a joint venture company that would have exclusive rights to produce and market renewable diesel and/or jet fuel. Should Total decide not to pursue commercialization, under certain conditions, it is eligible to recover up to $105 million, payable in March 2017, in the form of cash or in the form of common stock at a conversion price of $7.0682 per share.

Contract Manufacturing

In 2010 and 2011, to support our initial commercial production of Biofene , we entered into contract manufacturing agreements with Biomin, Tate & Lyle and Antibióticos.

We also established contract manufacturing relationships to support conversion of Biofene into finished chemical products. For example, in January 2011, we entered into a production service agreement with Glycotech under which Glycotech performs finishing steps to convert Biofene into squalane, diesel, base oils for industrial lubricants, and other products. In addition, in July 2011, we entered into a contract manufacturing agreement with Albemarle under which Albemarle is to provide toll manufacturing services at its facility in South Carolina and we are obligated to reimburse Albemarle for capital expenditures related to facility modifications required for the services. In February 2012, we entered into an amended and restated agreement with Albemarle, which superseded the original contract manufacturing agreement with Albemarle. The term of the new agreement continues through December 31, 2019.  The agreement includes certain obligations for us to pay fixed costs totaling $7.5 million , of which $3.5 million and $4.0 million are payable in 2012 and 2014, respectively. In addition, fixed costs of $2.0 million per quarter are payable in 2013 if we exercise our option to have product manufactured in the facility in 2013.  The agreement also includes variable pricing during the contract term. We may seek to enter into additional contract manufacturing arrangements. We expect to work with third parties specializing in particular industries to convert Biofene by simple chemical processes and initially to sell it primarily in the forms of squalane, diesel, base oils for industrial lubricants, and other products.

Under the terms of these contract manufacturing agreements, we provided necessary equipment for the manufacturing of products, over which we retained ownership. We also reimbursed the contract manufacturers for an aggregate of $13.8 million in expenditures related to the modification of their facilities, which we recorded as facility modification costs in other assets and amortized them as an offset against purchases of inventory. Certain of these contract manufacturing agreements also impose fixed purchase commitments on us, regardless of the production volumes.

Beginning in March 2012, we initiated a plan to shift production capacity from the contract manufacturing facilities to Amyris-owned plants that are currently under construction. As a result, we evaluated our contract manufacturing agreements and recorded a loss of $31.2 million related to $10.0 million in facility modification costs and $21.2 million of fixed purchase commitments in the first quarter of 2012. We recognized an additional charge of $1.4 million in the third quarter of 2012 associated with loss on fixed purchase commitments. We computed the loss on facility modification costs and fixed purchase commitments using the same lower of cost or market approach that is used to value inventory. The computation of the loss on firm purchase commitments is subject to several estimates, including cost to complete and the ultimate selling price of any of our products manufactured at the relevant production facilities, and is therefore inherently uncertain. We also recorded a loss on write off of production assets of $5.5 million related to Amyris-owned production equipment at contract manufacturing facilities in the three months ended March 31, 2012. We will continue to evaluate the potential for losses in future periods based on updated production and sales price assumptions.


49



During the three and nine months ended September 30, 2012 , we incurred $3.0 million and $33.2 million , respectively, of scale-up costs to support our production of farnesene-derived products that are included within cost of products sold. These scale-up costs include the contract manufacturing cost related to production of farnesene-derived products and the finishing of farnesene into finished products. We continue to commit significant resources to our production process in advance of our achieving full commercial production volume. As only a portion of our production costs varies with our revenue, our production costs will be greater than our revenue until we achieve significant product volume. We anticipate that our production costs will decrease as we continue to improve our processes and increase throughput.

Sales

To commercialize our initial farnesene derived product, squalane, for sale to cosmetics companies for use as a moisturizing ingredient in cosmetics and other personal care products, we entered into marketing and distribution agreements with a number of distributors since June 2010. As an initial step towards commercialization of farnesene based diesel, we have entered into agreements with several bus operators in Sao Paulo, Brazil. Our diesel fuel is supplied to BR Distribudora, a division of Petrobras, which in turn blends our product with petroleum diesel and sells to a number of bus operators including Santa Brigida, the largest bus fleet operator in Sao Paulo. For the industrial lubricants market, in June 2011 we established a joint venture with Cosan for the worldwide development, production and commercialization of renewable base oils. In September 2011, for development and commercialization of isoprene for use in tires, we entered into a development agreement with Michelin.
 
We have also entered into agreements to sell Biofene and its derivatives directly to various potential customers, including with P&G for use in cleaning products, with M&G for use in plastics, with Kuraray for use in production of polymers, with Firmenich and Givaudan for ingredients for the flavors and fragrances market, with Method for use in home and personal care products, and with Wilmar for use as a surfactant. Production and sale of our products pursuant to any of these relationships will depend on the achievement of contract-specific technical, development and commercial milestones.

Financing and Revenues

In the first three quarters of 2012, we have completed multiple financings involving loans and convertible debt and equity offerings. In February 2012, we completed a private placement of 10.2 million shares of common stock for total proceeds of $58.7 million and raised $25.0 million through convertible promissory notes. In May 2012, we completed a private placement of 1.7 million shares of common stock for an aggregate proceeds of $4.1 million . In July 2012, we completed a sale of a convertible promissory note for cash proceeds of $15.0 million and, in September 2012, we completed a sale of additional convertible promissory note for additional cash proceeds of $15.0 million . We expect to need additional financing in the coming quarters, and expect that such financing will include additional offerings of securities or incurring additional debt if such financing sources become available on appropriate terms for the company and its stockholders.

Since inception through September 30, 2012 , we have recognized $386.7 million in revenue, primarily from the sale of ethanol and reformulated ethanol-blended gasoline. We transitioned out of the ethanol and ethanol-blended business during the third quarter ended September 30, 2012, which resulted in the loss of the majority of such revenues during the period. We do not expect to be able to replace much of the revenues lost in the near term as a result of this transition, particularly in 2012 and 2013 while we continue our efforts to establish a renewable products business.

Liquidity

We expect to fund operations for the foreseeable future with cash and investments currently on hand, with cash inflows from existing collaboration and grant funding, cash contributions from product sales, and with new debt and equity financing. Our anticipated working capital needs and our planned operating and capital expenditures for the remainder of 2012 and for 2013 will require significant inflows of cash from collaboration partners, as well as funding from equity or debt offerings, credit facilities or loans, or combinations of these sources. Specifically, we will need to raise cash in the fourth quarter in order to fund our operations beyond the fourth quarter of 2012. Meeting our anticipated working capital needs and funding our strategic plans for the remainder of 2012 and for 2013 will depend on our ability to identify and secure substantial additional sources of funding beyond those we have currently identified. Furthermore, some of our anticipated financing sources are subject to risk that we cannot meet milestones, or are not yet subject to definitive agreements or funding commitments. If we fail to secure such funding in a timely manner, either in the short or long term, we may be forced to curtail our operations, which could include reductions or delays of planned capital expenditures or scaling back our operations. If we are forced to curtail our operations, we may be unable to proceed with construction of certain planned production facilities, including our planned large-scale production plants at Usina São Martinho and Paraíso Bioenergia, enter into definitive agreements for supply of feedstock and associated production arrangements that are currently subject to letters of intent, commercialize our products within the timeline we expect, or otherwise continue our business as currently contemplated.

50




If, to support our planned operations, we seek additional types of funding that involve the issuance of equity securities, our existing stockholders could suffer dilution. Furthermore, the convertible notes we have issued in recent financings include various covenants, including restrictions on the amount of debt we are permitted to incur. For example, our total outstanding debt at any time can not exceed the greater of $200.0 million or 50% of our consolidated total assets. We may conduct additional financings if they become available on appropriate terms and we deem them to be consistent with our financing strategy. If we raise additional debt financing, we may be subject to additional restrictive covenants that limit our ability to conduct our business and could cause us to be at risk of defaults.

We may not be able to raise sufficient additional funds on terms that are favorable to us, if at all. If we fail to raise sufficient funds and continue to incur losses, our ability to fund our operations, take advantage of strategic opportunities, develop and commercialize products or technologies, or otherwise respond to competitive pressures could be significantly limited. If this happens, we may be forced to delay or terminate research and development programs or the commercialization of products resulting from our technologies, curtail or cease operations, or obtain funds through collaborative and licensing arrangements that may require us to relinquish commercial rights, or grant licenses on terms that are not favorable to us. If adequate funds are not available, we will not be able to successfully execute our business plan or continue our business.

As part of our operating plan for 2012, we continually look at ways to reduce our cost structure by improving efficiency in our operations and reducing non-critical expenditures.  We expect these efforts to include adjustments to the timing and scope of planned capital and operating expenditures in the coming quarters.

Critical Accounting Policies and Estimates

Our discussion and analysis of our financial condition and results of operations is based upon our consolidated financial statements, which have been prepared in accordance with accounting principles generally accepted in the United States. The preparation of these consolidated financial statements requires us to make estimates and assumptions that affect the reported amounts of assets, liabilities, revenues, expenses and related disclosures. We base our estimates and assumptions on historical experience and on various other factors that we believe to be reasonable under the circumstances. We evaluate our estimates and assumptions on an ongoing basis. The results of our analysis form the basis for making assumptions about the carrying values of assets and liabilities that are not readily apparent from other sources. Our actual results may differ from these estimates under different assumptions or conditions.

We believe the following critical accounting policies involve significant areas of management’s judgments and estimates in the preparation of our financial statements.

Revenue Recognition

We currently recognize revenues from the sale of farnesene-derived products, from the delivery of collaborative research services and from government grants. Through the third quarter of 2012, we also sold ethanol and reformulated ethanol-blended gasoline under short-term agreements and in spot transactions at prevailing market prices. Revenues are recognized when all of the following criteria are met: persuasive evidence of an arrangement exists, delivery has occurred or services have been rendered, the fee is fixed or determinable and collectibility is reasonably assured.

If sales arrangements contain multiple elements, we evaluate whether the components of each arrangement represent separate units of accounting. We have determined that all of our revenue arrangements should be accounted for as a single unit of accounting. Application of revenue recognition standards requires subjective determination and requires management to make judgments about the fair values of each individual element and whether it is separable from other aspects of the contractual relationship.

For each source of revenues, we apply the above revenue recognition criteria in the following manner:

Product Sales

Starting in the second quarter of 2011, we commenced sales of farnesene-derived products. Through the third quarter of 2012 we also sold ethanol and reformulated ethanol-blended gasoline under short-term agreements and in spot transactions at prevailing market prices. Revenues are recognized, net of discounts and allowances, once passage of title and risk of loss have occurred, provided all other revenue recognition criteria have also been met.

Shipping and handling costs charged to customers are recorded as revenues. Shipping costs are included in cost of products

51



sold. Such charges were not significant in any of the periods presented.

Grants and Collaborative Research Services

Revenues from collaborative research services are recognized as the services are performed consistent with the performance requirements of the contract. In cases where the planned levels of research services fluctuate over the research term, we recognize revenues using the proportionate performance method based upon actual efforts to date relative to the amount of expected effort to be incurred by us. When up-front payments are received and the planned levels of research services do not fluctuate over the research term, revenues are recorded on a ratable basis over the arrangement term, up to the amount of cash received. When up-front payments are received and the planned levels of research services fluctuate over the research term, revenues are recorded using the proportionate performance method, up to the amount of cash received. Where arrangements include milestones that are determined to be substantive and at risk at the inception of the arrangement, revenues are recognized upon achievement of the milestone and is limited to those amounts whereby collectibility is reasonably assured.

Government grants are made pursuant to agreements that generally provide cost reimbursement for certain types of expenditures in return for research and development activities over a contractually defined period. Revenues from government grants are recognized in the period during which the related costs are incurred, provided that the conditions under which the government grants were provided have been met and only perfunctory obligations are outstanding. Under the DARPA contract signed in June 2012, we will receive funding based on achievement of program milestones and accordingly we will recognize revenue based on achievement of the milestones.

Consolidations

We have interests in certain joint venture entities that are variable interest entities or VIEs. Determining whether to consolidate a variable interest entity may require judgment in assessing (i) whether an entity is a variable interest entity and (ii) if we are the entity’s primary beneficiary and thus required to consolidate the entity. To determine if we are the primary beneficiary of a VIE, we evaluate whether we have (i) the power to direct the activities that most significantly impact the VIE’s economic performance and (ii) the obligation to absorb losses or the right to receive benefits of the VIE that could potentially be significant to the VIE. Our evaluation includes identification of significant activities and an assessment of our ability to direct those activities based on governance provisions and arrangements to provide or receive product and process technology, product supply, operations services, equity funding and financing and other applicable agreements and circumstances. Our assessment of whether we are the primary beneficiary of our VIEs requires significant assumptions and judgment.

Impairment of Long-Lived Assets

We assess impairment of long-lived assets, which include property and equipment and test long-lived assets for recoverability when events or changes in circumstances indicate that their carrying amount may not be recoverable. Circumstances which could trigger a review include, but are not limited to, significant decreases in the market price of the asset; significant adverse changes in the business climate or legal factors; accumulation of costs significantly in excess of the amount originally expected for the acquisition or construction of the asset; current period cash flow or operating losses combined with a history of losses or a forecast of continuing losses associated with the use of the asset; or expectations that the asset will more likely than not be sold or disposed of significantly before the end of its estimated useful life.

Recoverability is assessed based on the fair value of the asset, which is calculated as the sum of the undiscounted cash flows expected to result from the use and the eventual disposal of the asset. An impairment loss is recognized in the consolidated statements of operations when the carrying amount is determined not to be recoverable and exceeds fair value, which is determined on a discounted cash flow basis.

We make estimates and judgments about future undiscounted cash flows and fair values. Although our cash flow forecasts are based on assumptions that are consistent with our plans, there is significant exercise of judgment involved in determining the cash flow attributable to a long-lived asset over its estimated remaining useful life. Our estimates of anticipated cash flows could be reduced significantly in the future. As a result, the carrying amounts of our long-lived assets could be reduced through impairment charges in the future. We recorded losses on write off of production assets of $5.5 million and zero during the nine months ended September 30, 2012 and 2011 , respectively.

Inventories

Inventories, which consist of farnesene-derived products, ethanol and reformulated ethanol-blended gasoline, are stated at the lower of cost or market. In the quarter ended September 30, 2012 we sold the remaining inventory of ethanol and reformulated

52



ethanol-blended gasoline as we transitioned out of this business. We evaluate the recoverability of our inventories based on assumptions about expected demand and net realizable value. If we determine that the cost of inventories exceeds its estimated net realizable value, we record a write-down equal to the difference between the cost of inventories and the estimated net realizable value. If actual net realizable values are less favorable than those projected by management, additional inventory write-downs may be required that could negatively impact our operating results. If actual net realizable values are more favorable, we may have favorable operating results when products that have been previously written down are sold in the normal course of business. We also evaluate the terms of our agreements with our suppliers and establish accruals for estimated losses on adverse purchase commitments as necessary, applying the same lower of cost or market approach that is used to value inventory.

Goodwill and Intangible Assets 

Goodwill represents the excess of the cost over the fair value of net assets acquired from our business combinations. Intangible assets are comprised primarily of in-process research and development ('IPR&D"). We make significant judgments in relation to the valuation of goodwill and intangible assets resulting from business combinations and asset acquisitions.

 
There are several methods that can be used to determine the estimated fair value of the IPR&D acquired in a business combination. We have used the "income method," which applies a probability weighting that considers the risk of development and commercialization, to the estimated future net cash flows that are derived from projected sales revenues and estimated costs. These projections are based on factors such as relevant market size, pricing of similar products, and expected industry trends. The estimated future net cash flows are then discounted to the present value using an appropriate discount rate. These assets are treated as indefinite-lived intangible assets until completion or abandonment of the projects, at which time the assets will be amortized over the remaining useful life or written off, as appropriate.
 
Goodwill and intangible assets with indefinite lives are assessed for impairment using fair value measurement techniques on an annual basis or more frequently if facts and circumstance warrant such a review. When required, a comparison of fair value to the carrying amount of assets is performed to determine the amount of any impairment.

 
We evaluate our intangible assets with finite lives for indications of impairment whenever events or changes in circumstances indicate that the carrying value may not be recoverable. Intangible assets consist of purchased licenses and permits and are amortized on a straight-line basis over their estimated useful lives. Factors that could trigger an impairment review include significant under-performance relative to historical or projected future operating results, significant changes in the manner of our use of the acquired assets or the strategy for our overall business or significant negative industry or economic trends. If this evaluation indicates that the value of the intangible asset may be impaired, we make an assessment of the recoverability of the net carrying value of the asset over its remaining useful life. If this assessment indicates that the intangible asset is not recoverable, based on the estimated undiscounted future cash flows of the technology over the remaining amortization period, we will reduce the net carrying value of the related intangible asset to fair value and may adjust the remaining amortization period. Any such impairment charge could be significant and could have a material adverse effect on our reported financial results. We have not recognized any impairment charges on our intangible assets through September 30, 2012 .

Stock-Based Compensation

Stock-based compensation cost for RSUs is measured based on the closing fair market value of our common stock on the date of grant. Stock-based compensation cost for stock options and employee stock purchase plan rights is estimated at the grant date and offering date, respectively, based on the fair-value using the Black-Scholes option pricing model. We amortize the fair value of the employee stock options on a straight-line basis over the requisite service period of the award, which is generally the vesting period. The measurement of nonemployee stock-based compensation is subject to periodic adjustments as the underlying equity instruments vest, and the resulting change in value, if any, is recognized in our consolidated statements of operations during the period the related services are rendered. There is inherent uncertainty in these estimates and if different assumptions had been used, the fair value of the equity instruments issued to nonemployee consultants could have been significantly different.

In future periods, our stock-based compensation expense is expected to increase as a result of our existing unrecognized stock-based compensation still to be recognized and as we issue additional stock-based awards in order to attract and retain employees and nonemployee consultants.

Significant Factors, Assumptions and Methodologies Used In Determining Fair Value

We utilize the Black-Scholes option pricing model to estimate the fair value of our equity awards. The Black-Scholes option pricing model requires inputs such as the expected term of the grant, expected volatility and risk-free interest rate. Further, the

53



forfeiture rate also affects the amount of aggregate compensation that we are required to record as an expense. These inputs are subjective and generally require significant judgment.

The fair value of employee stock options was estimated using the following weighted-average assumptions:
 
Three Months Ended September 30,
 
Nine Months Ended September 30,
 
2012
 
2011
 
2012
 
2011
Expected dividend yield
%
 
%
 
%
 
%
Risk-free interest rate
0.9
%
 
1.3
%
 
1.1
%
 
2.4
%
Expected term (in years)
5.9

 
5.1

 
6.0

 
5.8

Expected volatility
79
%
 
85
%
 
76
%
 
86
%

Expected term is derived from a comparable group of publicly listed companies that has a similar industry, life cycle, revenue, and market capitalization and the historical data on employee exercises.

Expected volatility is derived from a combination of historical volatility for our stock and the historical volatilities of a comparable group of publicly listed companies within our industry over a period equal to the expected term of our options because we do not yet have a long trading history.

Risk-free interest rate is the market yield currently available on United States Treasury securities with maturities approximately equal to the option’s expected term.

Expected dividend yield was assumed to be zero as we have not paid, and do not anticipate, declaring any cash dividends to holders of our common stock in the foreseeable future.

We estimate our forfeiture rate based on an analysis of our actual forfeitures and will continue to evaluate the appropriateness of the forfeiture rate based on actual forfeiture experience, analysis of employee turnover and other factors. Quarterly changes in the estimated forfeiture rate can have a significant effect on reported stock-based compensation expense, as the cumulative effect of adjusting the rate for all expense amortization is recognized in the period the forfeiture estimate is changed. If a revised forfeiture rate is higher than the previously estimated forfeiture rate, an adjustment is made that will result in a decrease to the stock-based compensation expense recognized in the consolidated financial statements. If a revised forfeiture rate is lower than the previously estimated forfeiture rate, an adjustment is made that will result in an increase to the stock-based compensation expense recognized in the consolidated financial statements.

We will continue to use judgment in evaluating the expected term, volatility and forfeiture rate related to our own stock-based compensation on a prospective basis and incorporating these factors into the Black-Scholes option pricing model.

Each of these inputs is subjective and generally requires significant management and director judgment to determine. If, in the future, we determine that another method for calculating the fair value of our stock options is more reasonable, or if another method for calculating these input assumptions is prescribed by authoritative guidance, and, therefore, should be used to estimate expected volatility or expected term, the fair value calculated for our employee stock options could change significantly. Higher volatility and longer expected terms generally result in an increase to stock-based compensation expense determined at the date of grant.

Income Taxes

We are subject to income taxes in both the U.S. and foreign jurisdictions, and we use estimates in determining our provisions for income taxes. We use the liability method of accounting for income taxes, whereby deferred tax assets or liability account balances are calculated at the balance sheet date using current tax laws and rates in effect for the year in which the differences are expected to affect taxable income.

Recognition of deferred tax assets is appropriate when realization of such assets is more likely than not. We recognize a valuation allowance against our net deferred tax assets if it is more likely than not that some portion of the deferred tax assets will not be fully realizable. This assessment requires judgment as to the likelihood and amounts of future taxable income by tax jurisdiction. At September 30, 2012 , we had a full valuation allowance against all of our deferred tax assets.

We apply the provisions of FASB's guidance on accounting for uncertainty in income taxes. We assess all material positions taken in any income tax return, including all significant uncertain positions, in all tax years that are still subject to assessment or

54



challenge by relevant taxing authorities. Assessing an uncertain tax position begins with the initial determination of the position’s sustainability and the tax benefit to be recognized is measured at the largest amount of benefit that is greater than 50 percent likely of being realized upon ultimate settlement. As of each balance sheet date, unresolved uncertain tax positions must be reassessed, and we will determine whether (i) the factors underlying the sustainability assertion have changed and (ii) the amount of the recognized tax benefit is still appropriate. The recognition and measurement of tax benefits requires significant judgment. Judgments concerning the recognition and measurement of a tax benefit might change as new information becomes available.

Embedded Derivatives related to Convertible Notes

Embedded derivatives that are required to be bifurcated from the underlying debt instrument (i.e. host) are accounted for and valued as a separate financial instrument. We evaluated the terms and features of our convertible notes payable and identified a compound embedded derivative (a conversion option that contains a “make-whole interest” provision) requiring bifurcation and accounting at fair value because the economic and contractual characteristics of the embedded derivative met the criteria for bifurcation and separate accounting due to the conversion option containing a “make-whole interest” provision, that requires cash payment for forgone interest upon a change of control. We estimate the fair value of the compound embedded derivative using a Black-Scholes valuation model that combines expected cash outflows with market-based assumptions regarding risk-adjusted yields, stock price volatility, probability of a change of control and the trading information of our common stock into which the notes are convertible. The change in the fair value of the bifurcated compound derivative is primarily related to the change in price of the underlying common stock and is reflected in our consolidated statements of operations as “other income (expense)”.




55




Results of Operations

The following table sets forth our condensed consolidated statement of operations data for the periods shown (in thousands except share and per share amounts):

 
 
Three Months Ended September 30,
 
Nine Months Ended September 30,
 
2012

2011
 
2012
 
2011
 
(In Thousands, Except share and Per Share Amounts)
Consolidated Statement of Operations Data:
 
 
 
 
 
 
Revenues
 
 
 
 
 
 
 
Product sales
$
4,728

 
$
31,162

 
$
46,615

 
$
92,998

Grants and collaborations revenue
14,380

 
5,114

 
21,225

 
12,454

Total revenues
19,108

 
36,276

 
67,840

 
105,452

Costs and operating expenses

 

 
 
 
 
Cost of products sold
4,444

 
35,729

 
71,891

 
99,247

Loss on purchase commitments and write off of production assets
1,438

 

 
38,090

 

Research and development (1)
15,736

 
23,441

 
55,580

 
66,622

Sales, general and administrative (1)
17,355

 
21,174

 
61,301

 
59,401

Total costs and operating expenses
38,973

 
80,344

 
226,862

 
225,270

Loss from operations
(19,865
)
 
(44,068
)
 
(159,022
)
 
(119,818
)
Other income (expense):

 

 

 

Interest income
297

 
609

 
1,406

 
1,250

Interest expense
(1,224
)
 
(291
)
 
(3,538
)
 
(1,172
)
Other income (expense), net
664

 
310

 
(512
)
 
160

Total other income (expense)
(263
)
 
628

 
(2,644
)
 
238

Loss before income taxes
(20,128
)
 
(43,440
)
 
(161,666
)
 
(119,580
)
Provision for income taxes
(260
)
 
(474
)
 
(753
)
 
(299
)
Net loss
$
(20,388
)
 
$
(43,914
)
 
$
(162,419
)
 
$
(119,879
)
Net loss attributable to noncontrolling interest
95

 
224

 
772

 
437

Net loss attributable to Amyris, Inc. common stockholders
$
(20,293
)
 
$
(43,690
)
 
$
(161,647
)
 
$
(119,442
)
Net loss per share attributable to common stockholders, basic and diluted
$
(0.34
)
 
$
(0.97
)
 
$
(2.91
)
 
$
(2.68
)
Weighted-average shares of common stock outstanding used in computing net loss per share of common stock, basic and diluted
58,964,226

 
45,031,613

 
55,552,949

 
44,507,686

___________________________________________________
(1) Includes stock-based compensation expense.


56




Comparison of Three Months Ended September 30, 2012 and 2011

Revenues
 
 
Three Months Ended September 30,
 
Year-to-Year
Change
 
Percentage
Change
 
 
2012
 
2011
 
 
 
(Dollars in thousands)
 
 
Revenues
 
 
 
 
 
 
 
 
Product sales
 
$
4,728

 
$
31,162

 
$
(26,434
)
 
(85
)%
Grants and collaborations revenue
 
14,380

 
5,114

 
9,266

 
181
 %
Total revenues
 
$
19,108

 
$
36,276

 
$
(17,168
)
 
(47
)%

Our total revenues decreased by $17.2 million to $19.1 million from $36.3 million in the same period of 2011 , with such decrease primarily resulting from decreases in product sales. Revenue from product sales decreased by $26.4 million to $4.7 million primarily from lower sales of ethanol and reformulated ethanol-blended gasoline purchased from third parties, with a decrease in gallons sold and a decrease in average selling price per gallon compared to 2011 . We sold 0.2 million gallons of ethanol and 0.4 million gallons of reformulated ethanol-blended gasoline compared to 2.1 million gallons of ethanol and 8.5 million gallons of reformulated ethanol-blended gasoline sales in the prior year. Product sales of farnesene-derived products in the three months ended September 30, 2012 increased $3.0 million over the same period of prior year primarily due to sales of squalane and diesel fuels. Grants and collaborations revenue increased by $9.3 million over the same prior year period primarily due to the revenue recognized under our amended collaboration agreement with Total, which resulted in the recognition of approximately $9.8 million in collaboration revenue, partially offset by a decline in other grants and collaborations revenue of $0.5 million.

Nearly all of our revenues to date have come from the sale of ethanol and reformulated ethanol-blended gasoline with the remainder coming from renewable products as well as from collaborations and government grants. We transitioned out of the ethanol and ethanol-blended gasoline business during the third quarter ended September 30, 2012, which resulted in the loss of the majority of such revenues during the period. We do not expect to be able to replace much of the revenue lost in the near term as a result of this transition, particularly in 2012 and 2013 while we continue our efforts to establish a renewable products business.

Costs and Operating Expenses
 
 
Three Months Ended September 30,
 
Year-to-Year
Change
 
Percentage
Change
 
 
2012
 
2011
 
 
 
(Dollars in thousands)
 
 
Cost of products sold
 
$
4,444

 
$
35,729

 
$
(31,285
)
 
(88
)%
Loss on purchase commitments and write off of production assets
 
1,438

 

 
1,438

 
 %
Research and development
 
15,736

 
23,441

 
(7,705
)
 
(33
)%
Sales, general and administrative
 
17,355

 
21,174

 
(3,819
)
 
(18
)%
Total costs and operating expenses
 
$
38,973

 
$
80,344

 
$
(41,371
)
 
(51
)%
 
 
 
 
 
 
 
 
 

Cost of Products Sold

Our cost of products sold decreased by $31.3 million to $4.4 million compared to the prior year. We had a decrease of $29.9 million in costs of ethanol and reformulated ethanol-blended gasoline purchased from third parties primarily due to a decrease in product volume. Production cost of farnesene-derived products remained the same at approximately $3.0 million compared to the same period of the prior year. The cost of farnesene-derived products included charges related to the write down of inventory resulting from applying the lower-of-cost-or-market inventory rules.

We transitioned out of our ethanol and gasoline business in the quarter ended September 30, 2012, which resulted in a reduction of cost of products sold. We plan to make significant capital expenditures in connection with the construction of our large-scale production plant, and expect to continue to incur costs in connection with our contract manufacturing arrangements.

We expect cost of products sold associated with farnesene-derived products to decline if and when we achieve full-scale commercial production at our large-scale manufacturing facility. We are not able to predict when or if this will occur.

57



Cost of Products Sold Associated with Loss on Purchase Commitments

Beginning in March 2012, we initiated a plan to shift a portion of our production capacity from contract manufacturing facilities to Amyris-owned plants that are currently under construction. We recognized an additional charge of $1.4 million in the third quarter of 2012 associated with loss on fixed purchase commitments. We computed the loss on fixed purchase commitments using the same approach that is used to value inventory-the lower of cost or market value. The computation of the loss on firm purchase commitments is subject to several estimates, including the ultimate selling price of any of our products manufactured at the relevant production facilities, and is therefore inherently uncertain. In addition, many of our contract manufacturing agreements contain terms that commit us to pay for other costs incurred by the plant operators and owners, which could result in contractual liability for us even if we determine that we no longer wish to pursue a particular contract manufacturing arrangement.

Research and Development Expenses

Our research and development expenses decreased by $7.7 million in the third quarter of 2012 compared to the same period of the prior year, primarily the result of a $4.2 million decrease in outside consulting expenses and a $1.6 million decrease in personnel-related expenses associated with lower headcount and corresponding lower stock-based compensation. Research and development expenses included stock-based compensation expense of $1.5 million in 2012 compared to $1.7 million in 2011 .

Sales, General and Administrative Expenses

Our sales, general and administrative expenses decreased by $3.8 million in the third quarter of 2012 compared to the same period of the prior year, primarily the result of a $2.5 million decrease in personnel-related expenses and corresponding lower stock-based compensation associated with a change in headcount, $0.8 million decrease in professional services fees, and $0.4 million decrease in marketing expenses. Sales, general and administrative expenses included stock-based compensation expense of $4.5 million and $5.2 million during the third quarter of 2012 and 2011 , respectively.

Other Income (Expense)
 
 
 
Three Months Ended September 30,
 
Year-to-Year
Change
 
Percentage
Change
 
 
2012
 
2011
 
 
 
(Dollars in thousands)
 
 
Other income (expense):
 
 
 
 
 
 
 
 
Interest income
 
$
297

 
$
609

 
$
(312
)
 
(51
)%
Interest expense
 
(1,224
)
 
(291
)
 
(933
)
 
321
 %
Other income, net
 
664

 
310

 
354

 
114
 %
Total other income (expense)
 
$
(263
)
 
$
628

 
$
(891
)
 
(142
)%

Total other expense increased by approximately $0.9 million to $0.3 million in 2012 compared to the prior year. The increase in total other expense was related primarily to higher interest expense of $0.9 million associated with increased debt balances and lower interest income of $0.3 million , partially offset by higher other income, net in the 2012 period of approximately $0.4 million primarily related to the change in the fair value of the derivative liability associated with our amended collaboration agreement with Total. We expect interest expense to be greater in 2012 than in 2011 due to increased amounts of debt incurred to fund our operations, including capital expenditures for the coming year. We also may experience exposure to fluctuations in other expense, net in future periods related to changes in the market value of our currency interest rate swap agreement and changes in the fair value of our derivate liability associated with our amended collaboration agreement with Total.

Comparison of Nine Months Ended September 30, 2012 and 2011

Revenues
 
 
Nine Months Ended September 30,
 
Year-to-Year
Change
 
Percentage
Change
 
 
2012
 
2011
 
 
 
(Dollars in thousands)
 
 
Revenues
 
 
 
 
 
 
 
 
Product sales
 
$
46,615

 
$
92,998

 
$
(46,383
)
 
(50
)%
Grants and collaborations revenue
 
21,225

 
12,454

 
8,771

 
70
 %
Total revenues
 
$
67,840

 
$
105,452

 
$
(37,612
)
 
(36
)%

58




Our total revenues decreased by $37.6 million to $67.8 million with such decrease primarily resulting from decreases in product sales. Revenue from product sales decreased by $46.4 million to $46.6 million primarily from lower sales of ethanol and reformulated ethanol-blended gasoline purchased from third parties, with a decrease in gallons sold and a decrease in average selling price per gallon. We sold 2.3 million gallons of ethanol and 11.2 million gallons of reformulated ethanol-blended gasoline in the nine months ended September 30, 2012 compared to 8.5 million gallons of ethanol and 24.4 million gallons of reformulated ethanol-blended gasoline sales in the comparable period of the prior year. Product sales of our farnesene-derived products increased $7.7 million in the nine months ended September 30, 2012 compared to the same period in prior year. Grants and collaborations revenue increased by $8.8 million over the same prior year period primarily due to the revenue recognized under our amended collaboration agreement with Total which resulted in the recognition of approximately $9.8 million in collaboration revenue, partially offset by a decline in other collaboration revenue of $1.0 million.

Costs and Operating Expenses

 
 
Nine Months Ended September 30,
 
Year-to-Year
Change
 
Percentage
Change
 
 
2012
 
2011
 
 
 
(Dollars in thousands)
 
 
Cost of products sold
 
$
71,891

 
$
99,247

 
$
(27,356
)
 
(28
)%
Loss on purchase commitments and write off of production assets
 
38,090

 

 
38,090

 
nm

Research and development
 
55,580

 
66,622

 
(11,042
)
 
(17
)%
Sales, general and administrative
 
61,301

 
59,401

 
1,900

 
3
 %
Total costs and operating expenses
 
$
226,862

 
$
225,270

 
$
1,592

 
1
 %
______________ 
nm= not meaningful

Cost of Products Sold

Our cost of products sold decreased by $27.4 million to $71.9 million in the nine months ended September 30, 2012 compared to the same period the prior year. We had a decrease of $54.4 million in costs of ethanol and reformulated ethanol-blended gasoline purchased from third parties primarily due to a decline in product volume and a decrease in average unit cost. This decrease in cost of product sold for ethanol and reformulated ethanol-blended gasoline was partially offset by an increase in production costs of farnesene-derived products of $27.1 million in the nine months ended September 30, 2012 compared to the prior year as we scale up our renewable operations. The cost of farnesene-derived products included charges related to the write down of inventory resulting from applying the lower-of-cost-or-market inventory rules.

We expect cost of products sold associated with farnesene-derived products to decline if and when we achieve full-scale commercial production at our large-scale manufacturing facility. We are not able to predict when or if this will occur.

Cost of Products Sold Associated with Loss on Purchase Commitments and Write Off of Production Assets

Beginning in March 2012, we initiated a plan to shift production capacity from contract manufacturing facilities to Amyris-owned plants that are currently under construction. As a result, we evaluated our contract manufacturing agreements and, in the first quarter of 2012, recorded a loss of $31.2 million related to facility modification costs and fixed purchase commitments. We recognized an additional charge of $1.4 million in the third quarter of 2012 associated with loss on fixed purchase commitments. We computed the loss on facility modification costs and fixed purchase commitments using the same approach that is used to value inventory-the lower of cost or market value. The computation of the loss on firm purchase commitments is subject to several estimates, including the ultimate selling price of any of our products manufactured at the relevant production facilities, and is therefore inherently uncertain. We also recorded an impairment charge of $5.5 million in the three months ended March 31, 2012 related to Amyris-owned equipment at contract manufacturing facilities, based on the excess of the carrying value of the assets over their fair value.

Further impairment of such assets may occur in future quarters as we continue to evaluate and adjust our priorities for production, including the levels of utilization of our current and planned manufacturing facilities, which would cause us to incur additional future losses associated with such facilities. In addition, many of our contract manufacturing agreements contain terms that commit us to pay for other costs incurred by the plant operators and owners, which could result in contractual liability for us even if we determine that we no longer wish to pursue a particular contract manufacturing arrangement.

59




Research and Development Expenses

Our research and development expenses decreased by $11.0 million , primarily the result of an $8.8 million decrease in outside consulting expenses and a $1.1 million decrease in personnel-related expenses associated with lower headcount and corresponding lower stock-based compensation. Research and development expenses included stock-based compensation expense of $4.5 million in nine months ended September 30, 2012 compared to $4.7 million in 2011 .

Sales, General and Administrative Expenses

Our sales, general and administrative expenses increased by $1.9 million , primarily as a result of increased personnel-related expenses of $3.8 million associated with severance and transition costs and higher stock-based compensation, higher overhead costs of $1.9 million associated with increased headcount offset by a $1.7 million decrease in marketing expenses, a $1.2 million in decrease in professional service fees, and $1.2 million decrease in other sales, general and administrative expenses. Sales, general and administrative expenses included stock-based compensation expense of $16.9 million and $14.1 million during the nine months ended September 30, 2012 and 2011 , respectively.

Other Income (Expense)

 
 
Nine Months Ended September 30,
 
Year-to-Year
Change
 
Percentage
Change
 
 
2012
 
2011
 
 
 
(Dollars in thousands)
 
 
Other income (expense):
 
 
 
 
 
 
 
 
Interest income
 
$
1,406

 
$
1,250

 
$
156

 
12
 %
Interest expense
 
(3,538
)
 
(1,172
)
 
(2,366
)
 
202
 %
Other income (expense), net
 
(512
)
 
160

 
(672
)
 
(420
)%
Total other income (expense)
 
$
(2,644
)
 
$
238

 
$
(2,882
)
 
(1,211
)%

Total other expense increased by approximately $2.9 million to $2.6 million primarily due to higher interest expense of $2.4 million associated with increased debt balances and an increase in other expense, net of approximately $0.7 million primarily related to the change in fair value of our currency interest rate swap arrangement and the change in fair value of our derivative liability offset by an increase in interest income of $0.2 million . We expect interest expense to be greater in 2012 than in 2011 due to increased amounts of debt incurred to fund our operations, including capital expenditures for the coming year. We also may experience exposure to fluctuations in other expense, net in future periods related to changes in the market value of our currency interest rate swap agreement and changes in fair value of our derivative liability


Liquidity and Capital Resources
 
 
 
September 30, 2012
 
December 31, 2011
 
 
(Dollars in thousands)
Working capital
 
$
18,583

 
$
47,205

Cash and cash equivalents and short-term investments
 
$
44,429

 
$
103,592

Debt and capital lease obligations
 
$
108,776

 
$
47,660

Accumulated deficit
 
$
(542,835
)
 
$
(381,188
)
 
 
 
Nine Months Ended September 30,
 
 
2012
 
2011
 
 
(Dollars in thousands)
Net cash used in operating activities
 
$
(119,693
)
 
$
(65,768
)
Net cash provided by (used in) investing activities
 
$
(43,651
)
 
$
23,636

Net cash provided by financing activities
 
$
113,788

 
$
6,041


Working Capital. Working capital was $18.6 million at September 30, 2012 , a decrease of $28.6 million from working capital

60



as of December 31, 2011. This decrease was principally attributable to a reduction in net cash and investment balances of $59.2 million due primarily to investment in large scale production plants, and a decline of $9.9 million in other current assets largely related to the write off of facility modification costs at one of our contract manufacturing facilities. This decrease was offset in part by a reduction of $25.9 million in short term debt balances and a reduction of $14.9 million in accounts payable and accrued and other current liabilities.

To support production of our products in contract manufacturing and dedicated production facilities, we have incurred, and we expect to continue to incur, capital expenditures as we invest in these facilities.We plan to continue to seek external debt financing from U.S. and Brazilian sources to help fund our investment in these contract manufacturing and dedicated production facilities.

The timing and amount of capital expenditures for additional production facilities, at least in the near term will depend on our ability to access external sources of financing as well as our business and financial outlook. For example, we believe that the amount of financing that we agree to provide for the construction of bolt-on, or other, production facilities may influence the other terms of the arrangements that we establish with the facility owner, and, accordingly, expect to evaluate the optimal amount of capital expenditures that we agree to fund on a case-by-case basis. We may also consider additional strategic investments or acquisitions. These events may require us to access additional capital through equity or debt offerings. If we are unable to access additional capital, our growth may be limited due to the inability to invest in additional production facilities.

We believe that in order to fund our operations and other capital expenditures for the next twelve months we will be required to raise additional funds, in addition to our existing cash, cash equivalents and short-term investments at September 30, 2012 , cash inflows from existing collaboration, grants and product sales, and reductions in cash outflows as a result of planned actions.
Our anticipated working capital needs and our planned operating and capital expenditures for the remainder of 2012 and for 2013 will require significant inflows of cash from collaboration partners, as well as funding from equity or debt offerings, credit facilities or loans, or combinations of these sources. Specifically, we will need to raise cash in the fourth quarter in order to fund our operations beyond the fourth quarter of 2012. Meeting our anticipated working capital needs and funding our strategic plans for the remainder of 2012 and for 2013 will depend on our ability to identify and secure substantial additional sources of funding beyond those we have currently identified. Furthermore, some of our anticipated financing sources are subject to risk that we cannot meet milestones, or are not yet subject to definitive agreements or funding commitments. If we fail to secure such funding in a timely manner, either in the short or long term, we may be forced to curtail our operations, which could include reductions or delays of planned capital expenditures or scaling back our operations. If we are forced to curtail our operations, we may be unable to proceed with construction and commissioning of our planned large-scale production facilities at Usina São Martinho and Paraíso Bioenergia , enter into definitive agreements for supply of feedstock and associated production arrangements that are currently subject to letters of intent, commercialize our products within the timeline we expect, or otherwise continue our business as currently contemplated.
If, to support our planned operations, we seek additional types of funding that involve the issuance of equity securities, our existing stockholders would suffer dilution. Furthermore, the convertible notes we have issued in recent financings include various covenants, including restrictions on the amount of debt we are permitted to incur. For example our total outstanding debt at any time cannot exceed the greater of $200.0 million or 50% of our consolidated total assets. We may conduct additional financings if they become available on appropriate terms and we deem them to be consistent with our financing strategy. If we raise additional debt financing, we may be subject to additional restrictive covenants that limit our ability to conduct our business and could cause us to be at risk of defaults. For example, in February 2012, we completed the convertible note financing described below. The convertible notes contain various covenants, including restrictions on the amount of debt we are permitted to incur. We may conduct additional financings if they become available on appropriate terms and we deem them to be consistent with our financing strategy. If we raise additional debt financing, we may be subject to additional restrictive covenants that limit our ability to conduct our business and could cause us to be at risk of defaults.
We may not be able to raise sufficient additional funds on terms that are favorable to us, if at all. If we fail to raise sufficient funds and continue to incur losses, our ability to fund our operations, take advantage of strategic opportunities, develop and commercialize products or technologies, or otherwise respond to competitive pressures could be significantly limited. If this happens, we may be forced to delay or terminate research and development programs or the commercialization of products resulting from our technologies, curtail or cease operations, or obtain funds through collaborative and licensing arrangements that may require us to relinquish commercial rights, or grant licenses on terms that are not favorable to us. If adequate funds are not available, we will not be able to successfully execute our business plan or continue our business.

Beginning in March 2012, we initiated a plan to shift a portion of our production capacity from contract manufacturing facility to our Amyris-owned plant that is currently under construction. As a result, we evaluated our contract manufacturing agreements and recorded a loss of $31.2 million related to the write-off of $10.0 million in facility modification costs and the

61



recognition of $21.2 million of fixed purchase commitments in the three months ended, March 31, 2012. We recognized an additional charge of $1.4 million in the third quarter of 2012 associated with loss on fixed purchase commitments. We computed the loss on facility modification costs and fixed purchase commitments using the same lower of cost or market approach that is used to value inventory. The computation of the loss on firm purchase commitments is subject to several estimates, including cost to complete and the ultimate selling price of any of our products manufactured at the relevant production facilities, and is therefore inherently uncertain. We also recorded a loss on write off of production assets of $5.5 million related to Amyris-owned production equipment at contract manufacturing facilities in the quarter ended March 31, 2012.

Convertible Note Offering. In February 2012, we sold $25.0 million in principal amount of unsecured senior convertible promissory notes due March 1, 2017 . The notes have a 3.0% annual interest rate and are convertible into shares of our common stock at a conversion price of $7.0682 , subject to adjustment for proportional adjustments to outstanding common stock and anti-dilution provisions in case of dividends and distributions.  The note holders have a right to require repayment of 101% of the principal amount of the notes in an acquisition of Amyris, and the notes provide for payment of unpaid interest on conversion following such an acquisition if the note holders do not require such repayment.  The securities purchase agreement and notes include covenants regarding payment of interest, maintaining our listing status, limitations on debt, maintenance of corporate existence, and filing of SEC reports. The notes include standard events of default resulting in acceleration of indebtedness, including failure to pay, bankruptcy and insolvency, cross-defaults, and breaches of the covenants in the securities purchase agreement and notes, with default interest rates and associated cure periods applicable to the covenant regarding SEC reporting.

In July and September of 2012, we issued convertible notes to Total for an aggregate of $30.0 million in cash proceeds as described in more detail under "Overview - Total Relationship" above.

Common Stock Offerings. In February 2012, we sold 10,160,325 shares of our common stock in a private placement for aggregate offering proceeds of $58.7 million .

In May 2012, we completed a private placement of 1.7 million shares of our common stock for aggregate proceeds of $4.1 million .

Banco Pine Loans . In December 2011, we received a loan of R$35.0 million (approximately US$17.2 million based on the exchange rate as of September 30, 2012 ) from Banco Pine. Such loan was an advance on anticipated 2012 financing from Nossa Caixa, the Sao Paulo State development bank, and Banco Pine, under which Banco Pine and Nossa Caixa would provide us with loans of up to approximately R$52.0 million (approximately US$25.6 million based on the exchange rate at September 30, 2012 ) as financing for capital expenditures relating to our manufacturing facility at Paraíso Bioenergia. The maturity date for this loan was originally February 17, 2012; however, in February 2012, we entered into a supplemental agreement with Banco Pine under which the parties agreed to extend the maturity date for the repayment of the original loan from February 17, 2012 to May 17, 2012, and in May 2012, we entered into an additional supplemental extending the maturity date to August 15, 2012 . This loan was repaid in July 2012.

In June 2012, we entered into a separate loan agreement with Banco Pine under which Banco Pine provided a bridge Loan of R$52.0 million reais (approximately US$25.6 million based on the exchange rate as of September 30, 2012 ). The Bridge Loan was an additional advance on the anticipated Banco Pine and Nossa Caixa financing described above. The interest rate for the Bridge Loan is 0.4472% monthly (approximately 5.5% on an annualized basis). The principal and interest of this bridge loan matured and were required to be repaid on September 19, 2012 , subject to extension by Banco Pine. This bridge loan was repaid in July 2012.

We secured these loans to allow us to continue construction and process development at Paraiso, and expect to seek additional loans from this bank and others in order to be able to fund the establishment of other plants in Brazil and elsewhere.

Banco Pine/Nossa Caixa Financing . In July 2012, we entered into a Note of Bank Credit and a Fiduciary Conveyance of Movable Goods agreement with each of Nossa Caixa and Banco Pine. Under such instruments, we borrowed an aggregate of R$52.0 million (approximately US$25.6 million based on the exchange rate as of September 30, 2012 ) as financing for capital expenditures relating to our manufacturing facility at Paraíso Bioenergia. Under the loan agreements, Banco Pine agreed to lend R$22.0 million and Nossa Caixa agreed to lend R$30.0 million . The funds for these loans are provided by BNDES, but are guaranteed by the lenders. The loans have a final maturity date of July 15, 2022 and bear a fixed interest rate of 5.5% per year. The loans are secured by certain of our farnesene production system at the Paraíso Bioenergia manufacturing facility, and we were required to provide parent guarantees to each of the lenders.

BNDES Credit Facility . In December 2011, we entered into a credit facility in the amount of R$22.4 million (approximately

62



US$11.0 million based on the exchange rate as of September 30, 2012 ) with Banco Nacional de Desenvolvimento Econômico e Social, or BNDES, a government owned bank headquartered in Brazil. This BNDES facility was extended as project financing for a production site in Brazil. The credit line is divided into an initial tranche for up to approximately R$19.1 million and an additional tranche of approximately R$3.3 million reais that becomes available upon delivery of additional guarantees. The credit line is available for 12 months from the date of the Credit Agreement, subject to extension by the lender.

The principal of loans under the BNDES credit facility is required to be repaid in 60 monthly installments, with the first installment due in January 2013 and the last due in December 2017. Interest will be due initially on a quarterly basis with the first installment due in March 2012. From and after January 2013, interest payments will be due on a monthly basis together with principal payments. The loaned amounts carry interest of 7% per year. Additionally, a credit reserve charge of 0.1% on the unused balance from each credit installment from the day immediately after it is made available through its date of use, when it is paid.
 
The credit facility is collateralized by first priority security interest in certain of certain of our equipment and other tangible assets with an original purchase price of R$24.9 million reais. We are a parent guarantor for the payment of the outstanding balance under the BNDES credit facility. Additionally, we are required to provide a bank guarantee equal to 10% of the total approved amount (R$22.4 million reais in total debt) available under the credit facility. For advances in the second tranche (above R$19.1 million ), we are required to provide additional bank guarantees equal to 90% of each such advance, plus additional Amyris guarantees equal to at least 130% of such advance. The credit agreement contains customary events of default, including payment failures, failure to satisfy other obligations under the Credit Agreement or related documents, defaults in respect of other indebtedness, bankruptcy, insolvency and inability to pay debts when due, material judgments, and changes in control of Amyris Brasil. If any event of default under the credit agreement occurs, the lender may terminate its commitments and declare immediately due all borrowings under the facility. As of September 30, 2012 we had R$19.1 million (approximately US$9.4 million based on the exchange rate as of September 30, 2012 ) in outstanding advances under the BNDES Credit Facility.

FINEP Credit Facility. In November 2010, we entered into a credit facility with Financiadora de Estudos e Projetos, or FINEP, a state-owned company subordinated to the Brazilian Ministry of Science and Technology. This FINEP Credit Facility was extended to partially fund expenses related to our research and development project on sugarcane-based biodiesel, or the FINEP Project, and provides for loans of up to an aggregate principal amount of R$6.4 million (approximately US$3.2 million based on the exchange rate at September 30, 2012 ) which is guaranteed by a chattel mortgage on certain of our equipment as well as bank letters of guarantee. The first disbursement of approximately R$1.8 million reais was received on February 11, 2011 and the next three disbursements will each be approximately R$1.6 million reais. Subject to compliance with certain terms and conditions under the FINEP Credit Facility, the three remaining disbursements of the loan would become available to us for withdrawal.

Interest on loans drawn under this credit facility is fixed at 5.0% per annum. In case of default under or non-compliance with the terms of the agreement the interest on loans will be dependent on the long-term interest rate as published by the Central Bank of Brazil, or TJLP. If the TJLP at the time of default is greater than 6%, then the interest will be 5.0% + a TJLP adjustment factor otherwise the interest will be at 11.0% per annum. In addition, a fine of up to 10.0% will apply to the amount of any obligation in default. Interest on late balances will be 1.0% interest per month, levied on the overdue amount. Payment of the outstanding loan balance will be made in 81 monthly installments which will commence in July 2012 and extend through March 2019. Interest on loans drawn and other charges are paid on a monthly basis commencing in March 2011. As of September 30, 2012 and December 31, 2011 there were R$1.8 million (approximately US$0.9 million based on the exchange rate at September 30, 2012 ) outstanding under this FINEP Credit Facility.

The FINEP Credit Facility contains the following significant terms and conditions:

We will share with FINEP the costs associated with the FINEP Project. At a minimum, we will contribute approximately R$14.5 million reais ( US$7.1 million based on the exchange rate at September 30, 2012 ) of which R$11.1 million to be contributed prior to the release of the second disbursement, which is expected to occur in 2013;
After the release of the first disbursement, prior to any subsequent drawdown from the FINEP Credit Facility, we are required to provide letters of guarantee of up to R$3.3 million in aggregate (approximately US$1.6 million based on the exchange rate at September 30, 2012 );
Amounts released from the FINEP Credit Facility must be completely used by us towards the FINEP Project within 30 months after the contract execution.

Revolving Credit Facility. In December 2010, we established a revolving credit facility with a financial institution that provided for loans and standby letters of credit of up to an aggregate principal amount of $10.0 million, with a sublimit of $5.0 million on standby letters of credit. Interest on loans drawn under this revolving credit facility was equal to (i) the Eurodollar Rate plus 3.0%; or (ii) the Prime Rate plus 0.5%. In case of default or non-compliance with the terms of the agreement, the interest on

63



loans was Prime Rate plus 2.0%. The credit facility was collateralized by a first priority security interest in certain of our present and future assets. In April 2012, we paid $7.7 million of outstanding loans under this credit facility (see Note 6). In May 2012, we entered into a letter agreement with the bank amending the credit facility agreement to reduce the committed amount under the credit facility from $10.0 million to approximately $2.3 million , and the letters of credit sublimit from $5.0 million to approximately $2.3 million . The amendment also modified the current ratio covenant to require a ratio of current assets to current liabilities of at least 1.3 :1 (as compared to 2 :1 in the credit facility), and required us to maintain unrestricted cash of at least $15.0 million in its account with the bank. In June 2012, the credit facility was terminated and, as of September 30, 2012 , no loans or letters of credit were outstanding.

Amyris Fuels Credit Agreement. We had an uncommitted facility letter with a financial institution to finance the purchase and sale of fuel and for working capital requirements, as needed. We were a parent guarantor for the payment of the outstanding balance under the credit agreement. The agreement was collateralized by a first priority security interest in certain of our present and future assets. The agreement was terminated as of June 30, 2012 and, as of September 30, 2012 , we had zero in outstanding letters of credit under the Credit Agreement.

The fair values of the notes payable, loan payable, convertible notes and credit facility are based on the present value of expected future cash flows and assumptions about current interest rates and the creditworthiness of the Company that market participants would use in pricing the debt.

Government Contracts . In 2010, we were awarded a $24.3 million “Integrated Bio-Refinery” grant from the U.S. Department of Energy, or DOE. Under this grant, we are required to fund an additional $10.6 million in cost sharing expenses. According to the terms of the DOE grant, we were required to maintain a cash balance of $8.7 million, calculated as a percentage of the total project costs, to cover potential contingencies and cost overruns. As of September 30, 2012 , cash requirement is approximately US$1.0 million .These funds are not legally restricted but they must be available and unrestricted during the term of the project. Our obligation for this cost share is contingent on reimbursement for project costs incurred. Through September 30, 2012 , we recognized $22.1 million in revenue under this grant, of which $4.5 million was received during the nine months ended September 30, 2012 .
 
In August 2010, we were appointed as a subcontractor to National Renewable Energy Laboratory, or NREL, under a DOE grant awarded to NREL. We have the right to be reimbursed for up to $3.9 million, and are required to fund an additional $1.5 million, in cost sharing expenses. Through September 30, 2012 , we had recognized $1.1 million in revenue under this grant, of which $665,000 was received during the nine months ended September 30, 2012 .

In June 2012, we entered into a Technology Investment Agreement with The Defense Advanced Research Projects Agency (DARPA), under which we will perform certain research and development activities funded in part by DARPA. The work is to be performed on a cost-share basis, where DARPA funds 90% of the work and we fund the remaining 10% (primarily by providing specified labor). Under the agreement, we could receive funding of up to approximately $8.0 million over two years based on achievement of program milestones, and, accordingly, would be responsible for contributions equivalent to approximately $900,000. The agreement has an initial term of one year and, at DARPA's option, may be renewed for an additional year. Either party may terminate the agreement upon a reasonable determination that the program will not produce beneficial results commensurate with the expenditure of resources, subject to certain consultation obligations. We cannot be sure that we will receive the amount of funding available under the agreement. For example, we may not be able to meet the project milestones on a timely basis or at all. In addition, DARPA may determine that the project is not producing beneficial results commensurate with the expense, and seek to terminate the agreement. Furthermore, like the DOE grant, the DARPA contract requires us to implement certain governance and other processes, and DARPA may audit us and terminate the agreement if it determines we have failed to comply with such requirements.

Cash Flows during the Nine Months Ended September 30, 2012 and 2011

Cash Flows from Operating Activities

Our primary uses of cash from operating activities are cost of products sold and personnel-related expenditures offset by cash received from product sales. Cash used in operating activities was $119.7 million and $65.8 million for the nine months ended September 30, 2012 and 2011 , respectively.

Net cash used in operating activities of $119.7 million for the nine months ended September 30, 2012 reflected a net loss of $162.4 million and a $28.7 million net change in our operating assets and liabilities partially offset by non-cash charges of $71.4 million . The net change in operating assets and liabilities of $28.7 million primarily consisted of an $11.2 million decrease

64



in accounts payable, a $29.4 million decrease in accrued and other long term liabilities, a $1.3 million decrease in deferred revenue and a $0.9 million decrease in deferred rent partially offset by a $10.7 million decrease in prepaid expenses and other assets and a $2.9 million decrease in accounts receivable. Non-cash charges of $71.4 million were primarily related to $38.1 million of losses from firm purchase commitments and write off of production assets at contract manufacturers, $21.4 million of stock-based compensation, and $10.7 million of depreciation and amortization expenses.

Net cash used in operating activities of $65.8 million in the nine months ended September 30, 2011 reflected a net loss of $119.9 million partially offset by non-cash charges of $27.1 million and a $27.0 million net change in our operating assets and liabilities. Non-cash charges primarily included $18.8 million of stock-based compensation and $7.7 million of depreciation and amortization. Net change in operating assets and liabilities of $27.0 million primarily consists of a $17.7 million increase in accrued and other long term liabilities, an $11.0 million increase in accounts payable and a $4.6 million increase in deferred revenue partially offset by a $4.6 million increase in inventory and a $1.1 million increase in prepaid expenses and other assets.

Cash Flows from Investing Activities

Our investing activities consist primarily of capital expenditures, net investment purchases, maturities and sales.

For the nine months ended September 30, 2012 , cash used in investing activities was $43.7 million as a result of $50.9 million of capital expenditures and deposits on property and equipment, offset by net sales of short term investments of $8.2 million .

For the nine months ended September 30, 2011 , cash provided by investing activities was $23.6 million as a result of $94.5 million in net investment maturities and $0.3 million in acquisition of cash in noncontrolling interest offset by $71.2 million of capital expenditures and deposits on property and equipment.

Cash Flows from Financing Activities

For the nine months ended September 30, 2012 , cash provided by financing activities was $113.8 million , primarily the result of $105.6 million in debt financing and the receipt of $62.5 million in proceeds from sales of common stock in private placements, net of issuance costs. These cash inflows were offset in part by principal payments on debt of $52.1 million and principal payments on capital leases of $3.0 million .

For the nine months ended September 30, 2011 , cash provided by financing activities was $6.0 million , primarily the result of $7.6 million from debt financing and the receipt of $5.0 million in proceeds from option exercises. These cash receipts were offset in part by principal payments on debt of $4.0 million and principal payments on capital leases of $2.1 million

Off-Balance Sheet Arrangements

We did not have during the periods presented, and we do not currently have, any material off-balance sheet arrangements, as defined under SEC rules, such as relationships with unconsolidated entities or financial partnerships, which are often referred to as structured finance or special purpose entities, established for the purpose of facilitating financing transactions that are not required to be reflected on our consolidated financial statements.
 

65



Contractual Obligations

The following is a summary of our contractual obligations as of September 30, 2012 (in thousands):
 
 
 
Total
 
2012
(Three Months)
 
2013
 
2014
 
2015
 
2016
 
Thereafter
Principal payments on long-term debt
 
$
116,119

 
$
156

 
$
2,449

 
$
3,620

 
$
5,515

 
$
5,546

 
$
98,833

Interest payments on short- and long-term debt, fixed rate (1)
 
15,399

 
1,232

 
2,922

 
2,487

 
1,880

 
1,619

 
5,259

Operating leases
 
39,517

 
1,690

 
6,551

 
6,681

 
6,809

 
6,795

 
10,991

Principal payments on capital leases
 
3,366

 
756

 
1,366

 
957

 
287

 

 

Interest payments on capital leases
 
235

 
60

 
123

 
50

 
2

 

 

Terminal storage costs
 
142

 
53

 
89

 

 

 

 

Purchase obligations (2)
 
55,272

 
10,034

 
13,268

 
13,880

 
9,855

 
8,235

 

Total
 
$
230,050

 
$
13,981

 
$
26,768

 
$
27,675

 
$
24,348

 
$
22,195

 
$
115,083

______________ 
(1)
The interest rates are more fully described in Note 6 of our consolidated financial statements.
(2)
Purchase obligations include non-cancelable contractual obligations and construction commitments of $54.2 million , of which $14.3 million have been accrued as loss on purchase commitments.

This table does not reflect non-reimburseable expenses that we expect to incur in 2012 in connection with research activities under the DOE Integrated Bio-Refinery grant and the NREL subcontract discussed above under the caption "Liquidity and Capital Resources - Government Contracts." We have the right to be reimbursed for up to $24.3 million of a total of up to $34.9 million of expenses for research activities that we undertake under the DOE Integrated Bio-Refinery grant. We have the right to be reimbursed for up to $3.9 million of a total of $5.4 million of expenses for research activities that we undertake under the NREL grant.

Additionally, this table does not reflect the expenses that we expect to incur in 2012 and 2013 in connection with research activities under DARPA under which we will perform certain research and development activities funded in part by DARPA. The work is to be performed on a cost-share basis, where DARPA funds 90% of the work and we fund the remaining 10% (primarily by providing specified labor). Under the agreement, we could receive funding of up to approximately $8.0 million over two years based on achievement of program milestones, and, accordingly, we would be responsible for contributions equivalent to approximately $900,000.


Recent Accounting Pronouncements

The information contained in Note 2 to the Unaudited Condensed Consolidated Financial Statements under the heading recent accounting pronouncements is hereby incorporated by reference into this Part I, Item 2.


ITEM 3. QUANTITATIVE AND QUALITATIVE DISCLOSURES ABOUT MARKET RISK

We are exposed to financial market risks, primarily changes in interest rates, currency exchange rates and commodity prices. On a limited basis, we use derivative financial instruments primarily to manage commodity price risk.

Interest Rate Risk

Our exposure to market risk for changes in interest rates relates primarily to our investment portfolio and our outstanding debt obligations. We generally invest our cash in investments with short maturities or with frequent interest reset terms. Accordingly, our interest income fluctuates with short-term market conditions. As of September 30, 2012 , our investment portfolio consisted primarily of money market funds and certificates of deposit, all of which are highly liquid investments. Due to the short-term nature of our investment portfolio, our exposure to interest rate risk is minimal. Additionally, as of September 30, 2012 , 100% of our outstanding debt is in fixed rate instruments.

Foreign Currency Risk

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Certain of our sales contracts are denominated in foreign currencies and, therefore, our revenues are subject to foreign currency risks. In addition, we do incur certain of our production costs, primarily sugar feedstocks and manufacturing service fees, operating expenses and capital expenditures in currencies other than the U.S. dollar and, therefore, are subject to volatility in cash flows due to fluctuations in foreign currency exchange rates, particularly changes in the Brazilian reais. As of September 30, 2012 we have entered into a currency interest rate swap arrangement with Banco Pine for R$22.0 million (approximately US$10.8 million based on the exchange rate of September 30, 2012 ). The swap arrangement exchanges the principal and interest payments under the bridge loan for alternative principal and interest payments that are subject to adjustment based on fluctuations in the foreign exchange rate between the U.S. dollar and Brazilian real. The swap has a fixed interest rate of 3.94% . This arrangement hedges the fluctuations in the foreign exchange rate between the U.S. dollar and Brazilian real.

Commodity Price Risk

Our exposure to market risk for changes in commodity prices currently relates to our purchases of sugar feedstocks and through the third quarter of 2012, were also related to our purchases of ethanol and reformulated ethanol-blended gasoline. When possible, we manage our exposure to this risk primarily through the use of supplier pricing agreements. Through the third quarter of 2012, we also used standard derivative commodity instruments to hedge the price volatility of ethanol and reformulated ethanol-blended gasoline, principally through futures contracts but have, as of September 30, 2012, transitioned out of that business and no longer purchase any ethanol and reformulated ethanol-blended gasoline or use standard derivative commodity instruments.
 
The changes in fair value of these contracts are recorded on the balance sheet and recognized immediately in cost of products sold. We recognized a loss of $288,000 and $2.1 million as the change in fair value for the nine months ended September 30, 2012 and 2011 , respectively (see Note 3 to our Consolidated Financial Statements).

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ITEM 4. CONTROLS AND PROCEDURES

Disclosure Controls and Procedures

Our management, with the participation of our chief executive officer and chief financial officer, evaluated the effectiveness of our disclosure controls and procedures pursuant to Rule 13a-15 under the Exchange Act of 1934, as of the end of the period covered by this Quarterly Report on Form 10-Q.  Based on this evaluation, our chief executive officer ("CEO") and chief financial officer ("CFO") concluded that, as of September 30, 2012 , our disclosure controls and procedures are designed and are effective to provide reasonable assurance that information we are required to disclose in reports that we file or submit under the Exchange Act is recorded, processed, summarized, and reported within the time periods specified in the SEC's rules and forms, and that such information is accumulated and communicated to our management, including our CEO and CFO, as appropriate, to allow timely decisions regarding required disclosure.

Our management recognizes that any controls and procedures, no matter how well designed and operated, can provide only reasonable assurance of achieving their objectives and management necessarily applies its judgment in evaluating the cost-benefit relationship of possible controls and procedures.

Changes in Internal Control over Financial Reporting

There were no changes in our internal control over financial reporting identified in management’s evaluation pursuant to Rules 13a-15(d) or 15d-15(d) of the Exchange Act during our third fiscal quarter ended September 30, 2012 that materially affected, or are reasonably likely to materially affect, our internal control over financial reporting.


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PART II

ITEM 1. LEGAL PROCEEDINGS

We are not involved in any legal proceedings that management believes will have a material adverse effect on our business, results of operations, financial position or cash flows. We may, however, be involved, from time to time, in legal proceedings and claims arising in the ordinary course of our business. Such matters are subject to many uncertainties and there can be no assurance that legal proceedings arising in the ordinary course of business or otherwise will not have a material adverse effect on our business, results of operations, financial position or cash flows.



ITEM 1A. RISK FACTORS

Investing in our common stock involves a high degree of risk. You should carefully consider the risks and uncertainties described below, together with all of the other information set forth in this Quarterly Report on Form 10-Q, which could materially affect our business, financial condition or future results. If any of the following risks actually occurs, our business, financial condition, results of operations and future prospects could be materially and adversely harmed. The trading price of our common stock could decline due to any of these risks, and, as a result, you may lose all or part of your investment.

Risks Related to Our Business
We have incurred losses to date, anticipate continuing to incur losses in the future and may never achieve or sustain profitability.
As of September 30, 2012 , we had an accumulated deficit of $542.8 million . We expect to incur additional costs and expenses related to the continued development and expansion of our business, including construction and operation of our manufacturing facilities, our research and development operations, continued operation of our pilot plants and demonstration facility, and engineering and design work. Further, we expect to incur costs related to contract manufacturing arrangements. There can be no assurance that we will ever achieve or sustain profitability on a quarterly or annual basis.
We have very limited experience producing our products at the commercial scale needed for the development of our business.
To commercialize our products, we must be successful in using our yeast strains to produce target molecules at commercial scale and on an economically viable basis. Such production will require that our technology and processes be scalable from laboratory, pilot and demonstration projects, and industrial-scale test runs to commercial-scale production. Up to and through most of 2010, our primary focus was research and development. In 2011, we commenced commercial manufacturing operations at various contract manufacturing facilities. For longer term and more cost-effective production capacity, we are planning to shift most of our production capacity away from these contract manufacturing facilities and complete construction of our own large-scale production plants in Brazil. We have very limited manufacturing experience and cannot be sure that we will be successful in establishing these larger-scale production operations in a timely manner and on a scale that will allow us to meet our plans for commercialization. To help establish our operations, we have outsourced some of our production process development to the contract manufacturers and to other third parties and are relying on them to help us achieve production efficiency in our commercial scale-up efforts. Such third parties may not perform this work as well as we need them to in order for us to produce our products in a commercially viable manner. Based on, among other things, the foregoing risks and uncertainties associated with launching manufacturing facilities and our reliance on third parties to address some of the challenges, we may not be able to scale up our production in a timely manner, if at all. Even to the extent we successfully complete product development in our laboratories and pilot and demonstration facilities and conduct successful industrial-scale test runs, we may be unable to translate such success to commercial operations. If this occurs, our ability to commercialize our technology will be adversely affected, and, with respect to any products that we are able to bring to market, we may not be able to lower the cost of production, which would adversely affect our ability to sell our products and achieve profits. Similarly, our ability to produce the volume of Biofene covered by our existing offtake agreements is based in part on our ability to achieve substantially higher production efficiencies than we have to date. We may never achieve those production efficiencies.
We will require additional financing to fund our anticipated operations and may not be able to obtain such financing on favorable terms, if at all.
We will continue to need to fund our research and development and related activities and to provide working capital to fund production, storage, distribution and other aspects of our business. We may also from time to time consider acquisitions of other companies, assets or technologies to accelerate our research and development and commercialization efforts. In addition, we plan to make significant capital expenditures to construct and commission our large-scale production plants, and expect to continue to

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incur costs in connection with our contract manufacturing arrangements.
Our anticipated working capital needs and our planned operating and capital expenditures for the remainder of 2012 and for 2013 will require significant inflows of cash from collaboration partners, as well as funding from equity or debt offerings, credit facilities or loans, or combinations of these sources. Specifically, we will need to raise cash in the fourth quarter in order to fund our operations beyond the fourth quarter of 2012. Meeting our anticipated working capital needs and funding our strategic plans for the remainder of 2012 and for 2013 will depend on our ability to identify and secure substantial additional sources of funding beyond those we have currently identified. Furthermore, some of our anticipated financing sources are subject to risk that we cannot meet milestones or are not yet subject to definitive agreements or funding commitments. If we fail to secure such funding in a timely manner, either in the short or long term, we may be forced to curtail our operations, which could include reductions or delays of planned capital expenditures or scaling back our operations. If we are forced to curtail our operations, we may be unable to continue or complete construction of certain planned production facilities, including our planned large-scale production plants at Usina São Martinho and Paraíso Bioenergia, enter into definitive agreements for supply of feedstock and associated production arrangements that are currently subject to letters of intent, commercialize our products within the timeline we expect, or otherwise continue our business as currently contemplated.
If, to support our planned operations, we seek additional types of funding that involve the issuance of equity securities, our existing stockholders could suffer dilution. For example, in February 2012, we completed a private placement of our common stock that resulted in the issuance of approximately 10.2 million shares of our common stock and entered into a securities purchase agreement that resulted in the issuance of $25.0 million in unsecured senior convertible promissory notes that are convertible into common stock at an initial conversion price of $7.0682 . The convertible notes contain various covenants, including restrictions on the amount of debt we are permitted to incur. In May 2012, we completed another private placement of our common stock where we sold approximately 1.7 million shares of our common stock to certain members of our Board and parties related to them. In July 2012, we completed a sale of a convertible promissory note for cash proceeds of $15.0 million and, in September 2012, we completed a sale of an additional convertible promissory note for additional cash proceeds of $15.0 million . These notes issued in the third quarter of 2012 used the same conversion price and included the same covenants that were in the notes issued in February. We may conduct additional financings if they become available on appropriate terms and we deem them to be consistent with our financing strategy. If we raise additional debt financing, we may be subject to additional restrictive covenants that limit our ability to conduct our business and could cause us to be at risk of defaults.
We may not be able to raise sufficient additional funds on terms that are favorable to us, if at all. If we fail to raise sufficient funds and continue to incur losses, our ability to fund our operations, take advantage of strategic opportunities, develop and commercialize products or technologies, or otherwise respond to competitive pressures could be significantly limited. If this happens, we may be forced to delay or terminate research and development programs or the commercialization of products resulting from our technologies, curtail or cease operations, or obtain funds through collaborative and licensing arrangements that may require us to relinquish commercial rights, or grant licenses on terms that are not favorable to us. If adequate funds are not available, we will not be able to successfully execute our business plan or continue our business.
If our major production facilities in Brazil do not successfully commence operations, our customer relationships, business and results of operations may be adversely affected.
Our business plan envisions that we will develop our principal production capacity in Brazil, primarily through arrangements with existing sugar and ethanol producers, but we have not yet commenced commercial operation of any of our planned large-scale production plants in Brazil. In 2010, we entered into an agreement with Usina São Martinho, a sugar and ethanol producer in Brazil, for the joint ownership and development of a production facility at the Usina São Martinho mill. More recently, we entered into a manufacturing agreement with Paraíso Bioenergia, also in Brazil, under which we will be responsible for construction of a production facility. In late 2011 and 2012 we commenced a reassessment of the timing of construction projects relating to the Usina São Martinho plant due to financing constraints and a decision to seek proof of concept at a smaller scale. As a result, the timeline for Usina São Martinho is unclear and adjustments to the project, up to and including re-negotiation or termination of the agreements, are possible. The plan for Usina São Martinho depends on the timing and success of financing activities and production priorities. Based on these priorities and economic considerations relating to anticipated production costs at contract manufacturing facilities, we have adjusted our near-term focus to completion and commissioning the planned facility at Paraíso Bioenergia. A substantial component of our planned production capacity in the near and long term depends on the completion and commencement of operations at this production facility, and development of additional facilities using similar models thereafter.
Delays in completion of our large-scale production facilities will cause delays in our ramp-up of production and hamper our ability to reduce our production costs. For example, we have had to adjust our goals for production volume in 2012 and beyond based on, among other things, our ability to raise sufficient financing to fund construction and commissioning costs, delays in process development at contract manufacturing facilities, production economics at contract manufacturing facilities and related decisions regarding production volume at such facilities, and uncertainty relating to the timing of our planned large-scale facilities. Once our large-scale production facilities are operational, they must perform as we have designed them. If we encounter significant delays, cost overruns, engineering problems, equipment supply constraints or other serious challenges in bringing these facilities

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online, we may be unable to produce our initial renewable products in the time frame we have planned, or we may need to continue to use contract manufacturing sources to a greater degree, which would reduce our expected gross margins. Further, if our efforts to complete and commence production at these facilities are not successful, other mill owners in Brazil may decide not to work with us to develop additional production facilities, demand more favorable terms or delay their commitment to invest capital in our production.
Our construction of manufacturing facilities requires significant capital expenditures and subjects us to significant liquidity and production risks.
Our manufacturing facility at Paraíso Bioenergia is our principal focus for production capacity as we shift away from our dependence on contract manufacturing arrangements. Under the agreement with Paraíso Bioenergia, we are designing and building a fermentation and separation plant on leased space at the Paraíso Bioenergia facility, and we are responsible for financing the project. Our initial large-scale production facility construction plan was for the plant at Usina São Martinho and we were responsible for designing and managing the project. We had projected the construction costs of the new facility to total approximately $100 million, but we are currently delaying further work on our facility at Usina São Martinho due to financial constraints and a decision to seek proof of concept at a smaller scale . While Usina São Martinho was obligated under our agreement to contribute up to approximately R$61.8 million reais (approximately US$30.4 million based on the exchange rate as of September 30, 2012 ), such contributions depended on, among other things, successful commencement of commercial operations at the plant. Based on our shifting manufacturing priorities and uncertainty regarding financing availability, we cannot currently predict when or if our facility at Usina São Martinho will be completed or commence commercial operations, which means that Usina São Martinho's anticipated contribution will be delayed and may never occur. Even if we decide not to fund construction projects, we may not be able to quickly or completely cease incurring costs associated with such projects. For example, we have continued to incur costs associated with the Usina São Martinho project even after we decided to put that project on hold, and expect that such costs will continue as we pay for work already done or committed and scale down construction activity. We anticipate funding construction of our plants at Paraíso Bioenergia and, if we decide to start up construction again, Usina São Martinho, with our existing funds and with additional financing; however, we cannot be sure that we will be able to raise financing for these projects in sufficient amounts or on acceptable terms in a timely manner. If we fail to raise sufficient funds or are required to conserve working capital for other uses, we may be forced to delay or terminate projects, which could have a material adverse effect on our ability to achieve target production levels in the coming years.

The construction and commissioning of our plant at Paraíso Bioenergia is subject to execution and economic risks.
Our decision to focus our efforts for production capacity on the manufacturing facility at Paraíso Bioenergia and shift away from our dependence on contract manufacturers means that any failure to establish our plant at Paraíso Bioenergia could have a significant negative impact on our business, including our ability to achieve commercial viability for our products. The plant at Paraíso Bioenergia is under construction and we cannot be sure we will be able to complete construction and commissioning soon enough to commence commercial production to replace farnesene currently produced at contract manufacturing facilities. Furthermore, while we are moving our production focus to our plant at Paraíso Bioenergia based on an expectation that we will ultimately be able to produce farnesene at a lower cost using such facility, we cannot be sure when, or if, using such plant will in fact result in such lower production costs than contract manufacturing facilities. Also, with our facility at Paraíso Bioenergia, we will, for the first time, be the operator of a commercial fermentation and separation facility. We are inexperienced at operating plants and may face unexpected difficulties associated with the operation of the plant. For example, we have in the past, at certain contract manufacturing facilities, encountered significant delays and difficulties in ramping up production based on contamination in the production process, problems with plant utilities, lack of automation and related human error, issues arising from process modifications to reduce costs and adjust product specifications, and other similar challenges. Such challenges are likely to arise in our plant at Paraíso Bioenergia, and we cannot be certain that we will be able to remedy them quickly or effectively enough to achieve commercially viable near-term production costs and volumes.
As part of our arrangement to build the plant, we have an agreement with Paraíso Bioenergia that provides we are obligated to purchase from Paraíso Bioenergia sugarcane juice corresponding to up to a certain number of tons of sugarcane per year, along with specified water and vapor volumes. Until this annual volume is reached, we are restricted from purchasing sugarcane juice for processing in the facility from any third party, subject to limited exceptions, unless we pay the premium to Paraíso Bioenergia that we would have paid if we bought the juice from them. As such, we will be relying on Paraíso Bioenergia to supply such juice and utilities on a timely basis, in the volumes we need, and at competitive prices. If a third party can offer superior prices and Paraíso Bioenergia does not consent to our purchasing from such third party, we would be required to pay Paraíso Bioenergia the applicable premium, which would have a negative impact on our production cost. Furthermore, we agreed to pay a price for the juice that is based on the lower of the cost of two other products produced by Paraíso Bioenergia using such juice, plus a premium. Paraíso Bioenergia may not want to sell sugarcane juice to us if the price of one of the other products is substantially higher than the one setting the price for the juice we purchase. While the agreement provides that Paraíso Bioenergia would have to pay a penalty to us if it fails to supply the agreed-upon volume of juice for a given month, the penalty may not be enough to compensate

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us for the increased cost if third-party suppliers do not offer competitive prices. Also, if the prices of the other products produced by Paraíso Bioenergia increase, we could be forced to pay those increased prices for production without a related increase in the price at which we can sell our products, reducing or eliminating any margins we can otherwise achieve. If in the future these supply terms no longer provide a viable economic structure for the operation at Paraíso Bioenergia, we may be required to renegotiate our agreement, which could result in manufacturing disruptions and delays.

Our joint venture with Usina São Martinho subjects us to certain legal and financial terms that could adversely affect us.
In late 2011 and 2012 we commenced a reassessment of the timing for construction projects relating to our planned large-scale production facility at Usina São Martinho due to financing constraints and a decision to seek proof of concept at a smaller scale. As a result, the timeline for the plant at Usina São Martinho is unclear and adjustments to the project, up to and including re-negotiation or termination of the agreements relating to the production facility, are possible. The consequences of such actions could cause us to incur obligations and expenses under the agreements with Usina São Martinho.
Furthermore, even if we are successful in establishing the plant at Usina São Martinho, the agreements governing the joint venture subject us to terms that may not be favorable to us under certain conditions. Under the agreements governing the joint venture, upon the commencement of plant operations, the joint venture has agreed to purchase, and Usina São Martinho has agreed to provide, feedstock for a price that is based on the average return that Usina São Martinho could receive from the production of its current products, sugar and ethanol. If the cost of these products increases relative to the price at which we can sell the output that we are required to purchase from the joint venture, our return on sales of products produced by the joint venture would be adversely affected. We are required to purchase the output of the joint venture for the first four years at a price that guarantees the return of Usina São Martinho's investment plus a fixed interest rate. We may not be able to sell the output at a price that allows us to achieve anticipated, or any, level of profitability on the product we acquire under these terms. Similarly, the return that we are required to provide the joint venture for products after the first four years may have an adverse effect on the profitability we achieve from acquiring the mill's output. Finally, our purchase obligation with the mill requires us to purchase the output regardless of whether we have a customer for such output, and our results of operations and financial condition would be adversely affected if we are unable to sell the output that we are required to purchase.
If the joint venture fails to commence operations by the end of 2013, Usina São Martinho has the right to terminate the joint venture and require us to buy the joint venture's assets at fair value and transfer them to another location. In that event, we could incur significant costs and be required to find alternative locations for the facility. In addition, if Amyris Brasil becomes controlled, directly or indirectly, by a competitor of Usina São Martinho, then Usina São Martinho has the right to acquire our interest in the joint venture and if Usina São Martinho becomes controlled, directly or indirectly, by a competitor of ours, then we have the right to sell our interest in the joint venture to Usina São Martinho. In either case, the purchase price is to be determined in accordance with the joint venture agreements, and we would continue to have the obligation to acquire products produced by the joint venture for the remainder of the term of the supply agreement then in effect even though we might no longer be involved in the joint venture's management.
We may seek to enter into arrangements with Brazilian sugar and ethanol producers to produce a substantial portion of our products, and if we are not able to complete these arrangements in a timely manner and on terms favorable to us, our business will be adversely affected.
To expand our production in Brazil beyond that of our initial production facilities, we may seek to enter into agreements with other sugar and ethanol producers in Brazil that require them to make a substantial capital or operating contribution to partner with us to produce our renewable products. In return, we expect to provide them with a share of the higher gross margin we believe we will realize from the sale of these products relative to their existing products. There can be no assurance that a sufficient number of Brazilian sugar and ethanol mill owners will accept the opportunity to partner with us for the production of our products, whether on those terms or at all. Reluctance on the part of mill owners may be caused, for example, by their failure to understand our technology or product opportunities or agree with the greater economic benefits that we believe they can achieve from partnering with us. Mill owners may also be reluctant or unable to obtain needed capital, or they may be limited by existing contractual obligations with other third parties, liability, health and safety concerns, additional maintenance, training, operating and other ongoing expenses. We have entered into letters of intent with certain Brazilian sugar and ethanol producers to produce our products and Usina São Martinho has the option for production at a second mill, but these do not bind either the mill owner or us to enter into and proceed with a formal relationship. In addition, there are numerous issues regarding these mill relationships that must be successfully negotiated with each of the mill owners and we may not be successful in completing these negotiations. Even if sugar and ethanol producers are willing to build new facilities and produce our products, they may do so only on economic terms that place more of the cost, or confer less of the economic return, on us than we currently anticipate. If we are not successful in negotiations with sugar and ethanol mill owners, our cost of gaining this production capacity may be higher than we anticipate in terms of up-front costs, capital expenditure or lost future returns, and we may not gain the production base that we need in Brazil to allow us to grow our business.

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Building new, bolt-on facilities adjacent to existing sugar and ethanol mills for production of our products requires significant capital, and if mill owners are unwilling to contribute capital, or do not have or have access to this capital, production of our products would be more limited or more expensive than expected and our business would be harmed.
We expect to expand our production capacity over time using a capital light approach, through which mill owners would invest a substantial portion or all of the capital needed to build our bolt-on production facilities in exchange for a share of the higher gross margin from the sale of our renewable chemicals and fuels, as compared to their current products. Mill owners may perceive this construction as a costly process requiring excessive capital or operating contribution, or have concerns regarding our limited financial resources and the development stage of our business (particularly with respect to establishing manufacturing operations). Mill owners may not have sufficient capital of their own for this purpose or may not be willing or able to secure financing. As a result, they may choose not to contribute the amount of capital that we anticipate or may need to seek external sources of financing, which may not be available. If the mill owner needs to obtain financing through debt, we may be required to provide a guarantee. Furthermore, even if we are able to establish mill relationships where mill owners contribute desired levels of capital, we will be required to contribute significant capital ourselves, as is the case with our existing contract manufacturing arrangements and planned mill facilities. As we add relationships and commit to building additional production facilities, we will require additional financial resources to finance such projects, which could include equity financing, debt and additional contributions from existing and new collaboration partners. Even if sugar and ethanol producers are attracted to the opportunity, they may not be able to obtain credit to pursue it, which could adversely affect our ability to develop the production capacity needed to allow us to grow our business.
Our reliance on and relationships with contract manufacturers for near term production exposes us to risks relating to the costs, contractual terms, location, equipment installation, technology transfer and availability of that contract manufacturing and could adversely affect our growth.
We commenced commercial production of Biofene and some specialty chemical products in 2011 through the use of contract manufacturers, and we anticipate that we will continue to use contract manufacturers for chemical conversion and production of end-products, as well as for production of Biofene (even after Paraíso Bioenergia or a similar plant commences commercial operations) to mitigate cost and volume risks at our large-scale production facilities. Setting up sufficient contract manufacturing facilities requires us to make significant capital expenditures, which reduces our cash and places this capital at risk. We incurred, and expect to continue to incur, significant expenditures in connection with our contract manufacturing arrangements. Furthermore, based on an evaluation of our assets associated with contract manufacturing facilities and anticipated levels of use of such facilities, we recorded a loss on write off of production assets of approximately $5.5 million for the three months ended March 31, 2012. Further write off of such assets may occur in future quarters as we continue to evaluate and adjust our priorities for production, including the levels of utilization of our current and planned manufacturing facilities, which would cause us to incur additional losses associated with such facilities in the future. In addition, many of our contract manufacturing agreements contain terms that commit us to pay for capital expenditures and other costs incurred or expected to be earned by the plant operators and owners, which can result in contractual liability and losses for us even if we terminate a particular contract manufacturing arrangement or decide to reduce or stop production under such an arrangement. For example, we incurred a $31.2 million loss in the first quarter of 2012 related to $10.0 million in facility modification costs and $21.2 million of fixed purchase commitment losses associated with a scale-back of production at certain facilities. We recognized an additional charge of $1.4 million in the third quarter of 2012 associated with loss on fixed purchase commitments. Some of the contract manufacturing agreements also contain requirements to pay bonuses for milestone achievements by the contractor, minimum offtake requirements with penalties for failure to purchase specified amounts in a given period, and other terms that create contingent liabilities or other obligations for us. Any failure to comply with such requirements could result in legal claims against us, resulting in additional liability and diverting management attention, which could have a material adverse effect on our business. For example, in the second quarter of 2012, one of our contract manufacturers sent us a notice of termination and demanded payment of certain ongoing costs and removal of our equipment in connection with our decision to halt production at that plant, and we had to negotiate the termination of this relationship. Another of our contract manufacturers similarly made claims that we had breached an agreement by suspending production at that plant, and we had to negotiate a settlement of such claims.
Loss or termination of contract manufacturing relationships could be an additional source of risk. The failure to have multiple available supply options could create a risk for us if a single source or a limited number of sources of manufacturing runs into operational issues. In addition, if we are unable to secure the services of contract manufacturers when and as needed, we may lose customer opportunities and the growth of our business may be impaired. We cannot be sure that contract manufacturers will be available when we need their services, that they will be willing to dedicate a portion of their capacity to our projects, or that we will be able to reach acceptable price and other terms with them for the provision of their production services. If we shift priorities and stop or adjust anticipated production levels at contract manufacturing facilities, such adjustments could also result in disputes or otherwise harm our business relationships with contract manufacturers. In addition, reducing or stopping production at one facility while increasing or starting up production at another facility generally results in significant losses of production efficiency, which can persist for varying periods of time. Also, in order for production to commence under our contract manufacturing

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arrangements, we will generally have to provide equipment needed for the production of our products and we cannot be assured that such equipment can be ordered, or installed, on a timely basis, at acceptable costs, or at all. In addition, to establish new manufacturing facilities we need to transfer our yeast strains and production processes from lab to commercial plants controlled by third parties, which may pose technical or operational challenges that delay production or increase our costs.
The locations of contract manufacturers can pose additional cost, logistics and feedstock challenges. If production capacity is available at a plant that is remote from usable chemical finishing or distribution facilities, or from customers, we will be required to incur additional expenses in shipping products to other locations. Such costs could include shipping costs, compliance with export and import controls, tariffs and additional taxes, among others. In addition, we may be required to use feedstock from a particular region for a given production facility. The feedstock available in a particular region may not be the least expensive or most effective feedstock for production, which could significantly raise our overall production cost until we are able to optimize the supply chain.
If we are unable to decrease our production costs, we may not be able to produce our products at competitive prices and our ability to grow our business will be limited.
Currently, our costs of production are not low enough to allow us to offer many of our planned products at competitive prices. For us to establish significant sales of our specialty chemicals or fuels, we must achieve commercially-viable production efficiencies and cost structures. As discussed above, our strategy for achieving this goal includes moving production away from contract manufacturers and into our own large-scale production plants at sugar and ethanol mills to increase our scale of operations, improving feedstock supply and other production economics. This strategy is in its early stages and is subject to numerous risks, including execution risks associated with building, commissioning and running a new, Amyris-controlled production facility for the first time. Furthermore, our production costs depend on many factors that could have a negative effect on our ability to offer our planned products at competitive prices. Key factors beyond production scale and feedstock cost that impact our production costs include yield, productivity, separation efficiency and chemical process efficiency. Yield refers to the amount of the desired molecule that can be produced from a fixed amount of feedstock. Productivity represents the rate at which our product is produced by a given yeast strain. Separation efficiency refers to the amount of desired product produced in the fermentation process that we are able to extract and the time that it takes to do so. Chemical process efficiency refers to the cost and yield for the chemical finishing steps that convert our target molecule into a desired product. In order to successfully enter transportation fuels and certain chemical markets, we must produce those products at significantly lower costs, which will require both substantially higher yields than we have achieved to date and other significant improvements in production efficiency, including in productivity and in separation and chemical process efficiencies. There can be no assurance that we will be able to make these improvements or reduce our production costs sufficiently to offer our planned products at competitive prices, and any such failure could have a material adverse impact on our business and prospects.
Our ability to establish substantial commercial sales of our products is subject to many risks, any of which could prevent or delay revenue growth and adversely impact our customer relationships, business and results of operations.
There can be no assurance that our products will be approved or accepted by customers, that customers will choose our products over competing products, or that we will be able to sell our products profitably at prices and with features sufficient to establish demand. Although we are now selling squalane and some diesel fuel on a commercial basis, we are in the very early stages of selling our products into the commercial markets we are targeting. Our sales and marketing efforts for our initial products are primarily focused on a small number of target customers, and we need to continually establish that our products are comparable to, or better than, products they currently use that we seek to replace, ultimately both in terms of cost and performance. In addition, these customers will need to complete product qualification procedures, which may not be achieved in a timely manner or at all. We also face various risks related to commercial production, including obtaining assistance of contract manufacturers, production process development and production efficiency as discussed in the production risk factors above.
Our manufacturing operations require sugar feedstock, and the inability to obtain such feedstock in sufficient quantities or in a timely manner, or at reasonable prices, may limit our ability to produce our products.
We anticipate that the production of our products will require large volumes of feedstock. To date, we have been relying on a mixture of feedstock sources for use at our contract manufacturing operations, including cane sugar, corn-based dextrose and beet molasses. For our large-scale production facilities in Brazil, we expect to rely primarily on Brazilian sugarcane. We cannot predict the future availability or price of these various feedstocks, nor can we be sure that our mill partners, which we expect to supply the sugarcane feedstock necessary to produce our products in Brazil, will be able to supply it in sufficient quantities or in a timely manner. Furthermore, to the extent we are required to rely on sugar feedstock other than Brazilian sugarcane, the cost of such feedstock may be higher than we expect, increasing our anticipated production costs. Feedstock crop yields and sugar content depend on weather conditions, such as rainfall and temperature, that vary. Weather conditions have historically caused volatility in the ethanol and sugar industries by causing crop failures or reduced harvests. Excessive rainfall can adversely affect the supply

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of sugarcane and other sugar feedstock available for the production of our products by reducing the sucrose content and limiting growers' ability to harvest. Crop disease and pestilence can also occur from time to time and can adversely affect feedstock growth, potentially rendering useless or unusable all or a substantial portion of affected harvests. With respect to sugarcane, our initial primary feedstock, the limited amount of time during which it keeps its sugar content after harvest and the fact that sugarcane is not itself a traded commodity increases these risks and limits our ability to substitute supply in the event of such an occurrence. If production of sugarcane or any other feedstock we may use to produce our products is adversely affected by these or other conditions, our production will be impaired, and our business will be adversely affected.
We have entered into a number of agreements for the development, initial commercialization and sale of certain products that contain important technical, development and commercial milestones. If we do not meet those milestones our future revenue and financial results will be adversely impacted.
We have entered into a number of agreements regarding the further development of certain of our products and, in some cases, for ultimate sale to the customer under the agreement. None of these agreements affirmatively obligates the other party to purchase specific quantities of any products at this time, and most contain important conditions that must be satisfied before any such purchases would be made. These conditions include research and development milestones and technical specifications that must be achieved to the satisfaction of our customers, which we cannot be certain we will achieve. Some agreements provide that we will not initiate sales until we achieve advances in production efficiency to lower production costs. In addition, these agreements contain exclusivity and other terms that may limit our ability to commercialize our products and technology in ways that we do not currently envision. If we do not achieve these contractual milestones, our revenues and financial results will be harmed.
Our relationship with our strategic partner, Total, may have a substantial impact on our company.
We have entered into a strategic relationship with Total. As part of this relationship, Total has made significant equity investments in our company and has certain board membership rights, as well as certain first negotiation rights in the event of a sale of our company. As a result, Total will have access to a significant amount of information about our company and the ability to influence our management and affairs. Total's right of first negotiation may adversely affect our ability to complete a change in control transaction that our Board of Directors believes is in the best interests of stockholders other than Total.
We also entered into a license, development, research and collaboration agreement with Total, under which we may develop, produce and commercialize products with Total, which originally contemplated Total paying up to the first $50 million in research costs for selected research and development projects. Under the agreement, Total has a right of first negotiation with us with respect to exclusive commercialization arrangements that we would propose to enter into with certain third parties, as well as the right to purchase any of our products on terms not less favorable than those offered to or received by us from third parties in any market where Total or its affiliates have a significant market position. These rights might inhibit potential strategic partners or potential customers from entering into negotiations with us about future business opportunities. Total also has the right to terminate the collaboration agreement in the event we undergo a sale or change of control to certain entities, which could discourage a potential acquirer from making an offer to acquire us.

In November 2011, we entered into an amendment of the collaboration agreement with Total with respect to development and commercialization of Biofene for diesel. This represented an expansion of the initial collaboration that the parties established in 2010, and established a global, exclusive collaboration for the development of Biofene for diesel and a framework for the creation of a joint venture to manufacture and commercialize Biofene for diesel. In addition, a limited number of other potential products were subject to development for the joint venture on a non-exclusive basis. In July 2012, we entered into a further amendment of the collaboration agreement with Total that expanded Total's investment in the Biofene collaboration, incorporated the development of certain joint venture products for use in diesel and jet fuel into the scope of the collaboration, and changed the structure of the funding from Total to include a convertible debt mechanism. Under the new agreements, Total funded $30 million in new cash investment during the third quarter of 2012. Further funding will be triggered by Total at annual decision points in mid-2013 and 2014. Upon completion of the research and development program, we and Total would form a joint venture company that would have exclusive rights to produce and market renewable diesel and/or jet fuel. Should Total decide not to pursue commercialization, under certain conditions, it is eligible to recover up to $105 million, payable in March 2017, in the form of cash or in the form of common stock at a conversion price of $7.0682 per share.

Under the new agreements related to the July amendment, the $50 million in funding by Total originally contemplated under the collaboration agreement is deemed to be exhausted, so the funding under the most recent amendment is all the funding still contemplated by our agreements with Total. We cannot be certain that Total will choose to continue funding the research and development program or ultimately opt in to participate in the anticipated joint venture. Under the new agreements, Total may, at certain annual decision points through a final decision date following the earlier of completion of the research and development program or December 31, 2016, refuse to continue funding or participating in the program and, if it does, any notes issued to Total to date will remain outstanding and become payable or convertible into our common stock. If Total chooses to demand repayment

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of amounts advanced under the notes, we may not be able to repay them by the maturity date in March 2017 (the same maturity date as we have for $25 million in convertible promissory notes issued earlier in February 2012), which could lead to defaults and our insolvency, and Total and other creditors could pursue collection claims against us. If the notes become convertible and Total chooses to convert them, the resulting issuance of common stock would be dilutive to other stockholders.

The new agreements provide that we will provide an exclusive license to our intellectual property related to the manufacture and commercialization of Biofene-based diesel and jet fuel to the above-mentioned fuels joint venture, but also provide that we may be required to provide such a license to Total before formation of the joint venture under certain circumstances such as our insolvency. Furthermore, the new agreements contemplate that Total can, if there is a deadlock in finalizing various matters related to the formation of the joint venture, initiate a bidding process where the fair value of the proposed joint venture would be determined and we would be required to choose whether to (i) sell our joint venture assets to Total for 50% of the joint venture value, (ii) proceed with formation of the joint venture with Total as a 50% owner and accept Total's position regarding the funding requirements of the joint venture, or (iii) proceed with the formation of the joint venture with Total as a 50% owner, accepting Total's position regarding the funding requirements of the joint venture, and then sell all or a portion of our 50% interest in the joint venture to Total for a price equal to the fair value multiplied by the percentage ownership of the joint venture sold to Total. If we are forced to relinquish our rights with respect to diesel and jet fuel under these scenarios (or under an early exclusive license as described above), our ability to continue pursuing our fuels business will be impaired.

Loss of key personnel, including key management personnel, and/or failure to attract and retain additional personnel could delay our product development programs and harm our research and development efforts and our ability to meet our business objectives.
Our business involves complex, global operations across a variety of markets and requires a management team and employee workforce that is knowledgeable in the many areas in which we operate. As we build our business, we will need to hire additional qualified research and development, management and other personnel to succeed. The process of hiring, training and successfully integrating qualified personnel into our operation, in both the U.S. and Brazil, is a lengthy and expensive one. The market for qualified personnel is very competitive because of the limited number of people available with the necessary technical skills and understanding of our technology and anticipated products, particularly in Brazil. Our failure to hire and retain qualified personnel could impair our ability to meet our research and development and business objectives and adversely affect our results of operations and financial condition.
The loss of any key member of our management or key technical and operational employees, or the failure to attract or retain such employees could prevent us from developing and commercializing our products for our target markets and executing our business strategy. We also may not be able to attract or retain qualified employees in the future due to the intense competition for qualified personnel among biotechnology and other technology-based businesses, particularly in the renewable chemicals and fuels area, or due to the availability of personnel with the qualifications or experience necessary for our business. In addition, our stock price has declined significantly over the last year, which may reduce our ability to recruit and retain employees using equity compensation. If we are not able to attract and retain the necessary personnel to accomplish our business objectives, we may experience staffing constraints that will adversely affect our ability to meet the demands of our collaborators and customers in a timely fashion or to support our internal research and development programs. In particular, our product and process development programs are dependent on our ability to attract and retain highly skilled technical and operational personnel. Competition for such personnel from numerous companies and academic and other research institutions may limit our ability to do so on acceptable terms. All of our employees are at-will employees, which mean that either the employee or we may terminate their employment at any time.

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An increase in the price and profitability of ethanol and sugar relative to our products could adversely affect our arrangements with sugar and ethanol producers.
In order to induce owners of sugar and ethanol facilities to partner with us to produce our products, we generally have planned to compensate them for the production of our products based on the revenue they would have realized had they instead produced their traditional products, plus any incremental costs incurred in the production of our products over their usual production costs. Also, our discussions and agreements with mill owners have contemplated sharing a portion of the realized gross margin on any sales of products with these mill owners. An increase in the price of ethanol or sugar relative to the price at which we can sell our products could result in the production cost of our products increasing without a corresponding increase in the price at which we can sell our products. In this event our results of operations would be adversely affected. If ethanol prices are sufficiently high that the return from converting a given amount of sugarcane to ethanol exceeds the return from converting that amount of sugarcane into our products, then we will have to compensate the mill owner for that loss or risk the mill owner reverting to the production of ethanol and not producing our products at all. Many factors could cause this unfavorable price dislocation. If sugar prices increase over a sustained period of time, this may encourage sugar production at the expense of ethanol in mills with flexibility to produce both products, which in turn could cause domestic prices in Brazilian reais for ethanol to increase. In addition, the Brazilian government currently requires the use of anhydrous ethanol as a gasoline additive. Any change in these government policies could affect ethanol demand in a way that discourages mill owners from producing our products.
The price of sugarcane and other feedstocks can be volatile as a result of changes in industry policy and may increase the cost of production of our products.
In Brazil, Conselho dos Produtores de Cana, Açúcar e Álcool (Council of Sugarcane, Sugar and Ethanol Producers), or Consecana, an industry association of producers of sugarcane, sugar and ethanol, sets market terms and prices for general supply, lease and partnership agreements for sugarcane. Changes in such prices and terms could result in higher sugarcane prices and/or a significant decrease in the volume of sugarcane available for the production of our products. If Consecana were to cease to be involved in this process, such prices and terms could become more volatile. Similar principles apply to pricing of other feedstocks as well. Any of these events could adversely affect our business and results of operations.
Our initial large-scale commercial production capacity is planned for Brazil, and our business will be adversely affected if we do not operate effectively in that country.
For the foreseeable future, we will be subject to risks associated with the concentration of essential product sourcing and operations in Brazil. In the past, the Brazilian economy was characterized by frequent and occasionally extensive intervention by the Brazilian government and unstable economic cycles. The Brazilian government has changed in the past, and may change in the future, monetary, taxation, credit, tariff and other policies to influence the course of Brazil's economy. For example, the government's actions to control inflation have at times involved setting wage and price controls, adjusting interest rates, imposing taxes and exchange controls and limiting imports into Brazil. We have no control over, and cannot predict, what policies or actions the Brazilian government may take in the future. For example, the Brazilian government may take actions to support state-controlled entities in our industry that could adversely affect us. Our business, financial performance and prospects may be adversely affected by, among others, the following factors:

delays or failures in securing licenses, permits or other governmental approvals necessary to build and operate facilities and use our yeast strains to produce products;
rapid consolidation in the sugar and ethanol industries in Brazil, which could result in a decrease in competition;
political, economic, diplomatic or social instability in or affecting Brazil;
changing interest rates;
tax burden and policies;
effects of changes in currency exchange rates;
exchange controls and restrictions on remittances abroad;
inflation;
land reform movements;
export or import restrictions that limit our ability to move our products out of Brazil or interfere with the import of essential materials into Brazil;
changes in or interpretations of foreign regulations that may adversely affect our ability to sell our products or repatriate profits to the U.S.;

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tariffs, trade protection measures and other regulatory requirements;
successful compliance with U.S. and foreign laws that regulate the conduct of business abroad;
an inability, or reduced ability, to protect our intellectual property in Brazil including any effect of compulsory licensing imposed by government action; and
difficulties and costs of staffing and managing foreign operations. 
Such factors could have a material adverse impact on our results of operations and financial condition.
We cannot predict whether the current or future Brazilian government will implement changes to existing policies on taxation, exchange controls, monetary strategy and social security, among others. We cannot estimate the impact of any such changes on the Brazilian economy or our operations.
We may face risks relating to the use of our genetically modified yeast strains and if we are not able to secure regulatory approval for the use of our yeast strains or if we face public objection to our use of them, our business could be adversely affected.
The use of genetically-modified microorganisms, or GMMs, such as our yeast strains, is subject to laws and regulations in many countries, some of which are new and some of which are still evolving. Public attitudes about the safety and environmental hazards of, and ethical concerns over, genetic research and GMMs could influence public acceptance of our technology and products. In the U.S., the Environmental Protection Agency, or EPA, regulates the commercial use of GMMs as well as potential products from the GMMs. Various states within the U.S. could choose to regulate products made with GMMs as well. While the strain of genetically modified yeast that we currently use for the development and anticipate using for the commercial production of our target molecules, S. cerevisiae , is eligible for exemption from EPA review because it is recognized as posing a low risk, we must satisfy certain criteria to achieve this exemption, including but not limited to use of compliant containment structures and safety procedures, and we cannot be sure that we will meet such criteria in a timely manner, or at all. If exemption of S. cerevisiae is not obtained, our business may be substantially harmed. In addition to S. cerevisiae , we may seek to use different GMMs in the future that will require EPA approval. If approval of different GMMs is not secured, our ability to grow our business could be adversely affected.
In Brazil, GMMs are regulated by the National Biosafety Technical Commission, or CTNBio. We have obtained approval from CTNBio to use GMMs in a contained environment in our Campinas facilities for research and development purposes as well as at a contract manufacturing facility in Brazil. In addition, we have obtained initial commercial approval from CTNBio for one of our current yeast strains. As we continue to develop new yeast strains and deploy our technology at new production facilities in Brazil, we will be required to obtain further approvals from CTNBio in order to use these strains in commercial production in Brazil. We may not be able to obtain approvals from relevant Brazilian authorities on a timely basis, or at all, and if we do not, our ability to produce our products in Brazil would be impaired, which would adversely affect our results of operations and financial condition.
In addition to our production operations in the U.S. and Brazil, we have been party to contract manufacturing agreements with parties in other production locations around the world, including Europe. The use of GMM technology is strictly regulated in the European Union, which has established various directives for member states regarding regulation of the use of such technology, including notification processes for contained use of such technology. We expect to encounter GMM regulations in most, if not all, of the countries in which we may seek to establish production capabilities, and the scope and nature of these regulations will likely be different from country to country. If we cannot meet the applicable requirements in other countries in which we intend to produce products using our yeast strains, or if it takes longer than anticipated to obtain such approvals, our business could be adversely affected.
We may not be able to obtain regulatory approval for the sale of our renewable products.
Our renewable chemical products may be subject to government regulation in our target markets. In the U.S., the EPA administers the Toxic Substances Control Act, or TSCA, which regulates the commercial registration, distribution, and use of many chemicals. Before an entity can manufacture or distribute significant volumes of a chemical, it needs to determine whether that chemical is listed in the TSCA inventory. If the substance is listed, then manufacture or distribution can commence immediately. If not, then in most cases a “Chemical Abstracts Service” number registration and pre-manufacture notice must be filed with the EPA, which has up to 180 days to review the filing. Some of the products we produce or plan to produce, such as Biofene and squalane, are already in the TSCA inventory. Others, such as our farnesane (diesel) and new jet fuel molecules, are not yet listed. We may not be able to expediently receive approval from the EPA to list the molecules we would like to make on the TSCA registry, resulting in delays or significant increases in testing requirements. A similar program exists in the European Union, called REACH (Registration, Evaluation, Authorization, and Restriction of Chemical Substances). Under this program, we need to register our

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products with the European Commission, and this process could cause delays or significant costs. To the extent that other geographies, such as Brazil, may rely on TSCA or REACH (or similar laws and programs) for chemical registration in their geographies, delays with the U.S. or European authorities may subsequently delay entry into these markets as well.
Our diesel fuel is subject to regulation by various government agencies, including the EPA and the California Air Resources Board in the U.S. and Agência Nacional do Petróleo, or ANP, in Brazil. To date, we have obtained registration with the EPA for the use of our diesel in the U.S. at a 35% blend rate with petroleum diesel. We are currently working to secure ANP approval for use of our diesel in Brazil at a 10% blend rate. We are also currently in the process of registration of our fuel with the California Air Resources Board and the European Commission. Registration with each of these bodies is required for the sale and use of our fuels within their respective jurisdictions. In addition, for us to achieve full access to the U.S. fuels market for our fuel products, we will need to obtain EPA and California Air Resources Board (and potentially other state agencies) certifications for our feedstock pathway and production facilities, including certification of a feedstock lifecycle analysis relating to greenhouse gas emissions. Any delay in obtaining these additional certifications could impair our ability to sell our renewable fuels to refiners, importers, blenders and other parties that produce transportation fuels as they comply with Federal and state requirements to include certified renewable fuels in their products.
We expect to encounter regulations in most, if not all, of the countries in which we may seek to sell our renewable chemical and fuel products, and we cannot assure you that we will be able to obtain necessary approvals in a timely manner or at all. If our chemical and fuel products do not meet applicable regulatory requirements in a particular country or at all, then we may not be able to commercialize our products and our business will be adversely affected.
We cannot assure you that our products will be approved or accepted by customers or end consumers in specialty chemical markets.
The markets we intend to enter first are primarily those for specialty chemical products used by large consumer products or specialty chemical companies. In entering these markets, we intend to sell our products as alternatives to chemicals currently in use, and in some cases the chemicals that we seek to replace have been used for many years. The potential customers for our molecules generally have well developed manufacturing processes and arrangements with suppliers of the chemical components of their products and may have a resistance to changing these processes and components. These potential customers frequently impose lengthy and complex product qualification procedures on their suppliers, influenced by consumer preference, manufacturing considerations such as process changes and capital and other costs associated with transitioning to alternative components, supplier operating history, regulatory issues, product liability and other factors, many of which are unknown to, or not well understood by, us. Satisfying these processes may take many months or years. If we are unable to convince these potential customers (and the consumers who purchase products containing such chemicals) that our products are comparable to the chemicals that they currently use or that the use of our products is otherwise to their benefits, we will not be successful in entering these markets and our business will be adversely affected.
If we are unable to satisfy the significant product qualification requirements of equipment manufacturers, we may not be able to successfully enter markets for transportation fuels, and our business would be adversely affected.
In order for our diesel fuel product to be accepted in various countries around the world, diesel engine manufacturers must determine that the use of our fuels in their equipment will not invalidate product warranties and that they otherwise regard our diesel as an acceptable fuel. In addition, we must successfully demonstrate to these manufacturers that our fuel does do not degrade the performance or reduce the life cycle of their engines or cause them to fail to meet emissions standards. Meeting these suitability standards can be a time consuming and expensive process, and we may invest substantial time and resources into such qualification efforts without ultimately securing approval. To date, our diesel fuel products have achieved limited approvals from certain engine manufacturers, but we cannot be assured that other engine or vehicle manufacturers or fleet operators, will approve usage of our fuels. Although our diesel fuel satisfies existing pipeline operator and fuel distributor requirements, such fuel has not been reviewed nor transported by such operators as of this date. If these operators impose volume limitations on the transport of our fuels, our ability to sell our fuels may be impaired.
Our ability to sell a jet fuel product will be subject to the same types of qualification requirements as our diesel fuel, although we believe the qualification process will take longer and will be more expensive than the process for diesel.
Our international operations expose us to the risk of fluctuation in currency exchange rates and rates of foreign inflation, which could adversely affect our results of operations.
We currently incur some costs and expenses in Brazilian reais and may in the future incur additional expenses in foreign currencies and derive a portion of our revenues in the local currencies of customers throughout the world. As a result, our revenues and results of operations are subject to foreign exchange fluctuations, which we may not be able to manage successfully. During the past few decades, the Brazilian currency in particular has faced frequent and substantial exchange rate fluctuations in relation

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to the U.S. dollar and other foreign currencies. There can be no assurance that the Brazilian real will not significantly appreciate or depreciate against the U.S. dollar in the future.
We bear the risk that the rate of inflation in the foreign countries where we incur costs and expenses or the decline in value of the U.S. dollar compared to those foreign currencies will increase our costs as expressed in U.S. dollars. For example, future measures by the Central Bank of Brazil to control inflation, including interest rate adjustments, intervention in the foreign exchange market and actions to fix the value of the real, may weaken the U.S. dollar in Brazil. Whether in Brazil or otherwise, we may not be able to adjust the prices of our products to offset the effects of inflation or foreign currency appreciation on our cost structure, which could increase our costs and reduce our net operating margins. If we do not successfully manage these risks through hedging or other mechanisms, our revenues and results of operations could be adversely affected.
We expect to face competition for our specialty chemical and transportation fuels products from providers of petroleum-based products and from other companies seeking to provide alternatives to these products, and if we cannot compete effectively against these companies or products we may not be successful in bringing our products to market or further growing our business after we do so.
We expect that our renewable products will compete with both the traditional, largely petroleum-based specialty chemical and fuels products that are currently being used in our target markets and with the alternatives to these existing products that established enterprises and new companies are seeking to produce.
In the specialty chemical markets that we are initially seeking to enter, and in other chemical markets that we may seek to enter in the future, we will compete primarily with the established providers of chemicals currently used in these products. Producers of these incumbent products include global oil companies, large international chemical companies and companies specializing in specific products, such as squalane or essential oils. We may also compete in one or more of these markets with products that are offered as alternatives to the traditional petroleum-based or other traditional products being offered in these markets.
 
In the transportation fuels market, we expect to compete with independent and integrated oil refiners, advanced biofuels companies and biodiesel companies. These refiners compete with us by selling traditional fuel products and some are also pursuing hydrocarbon fuel production using non-renewable feedstocks, such as natural gas and coal, as well as processes using renewable feedstocks, such as vegetable oil and biomass. We also expect to compete with companies that are developing the capacity to produce diesel and other transportation fuels from renewable resources in other ways. These include advanced biofuels companies using specific enzymes that they have developed to convert cellulosic biomass, which is non-food plant material such as wood chips, corn stalks and sugarcane bagasse, into fermentable sugars. Similar to us, some companies are seeking to use engineered enzymes to convert sugars, in some cases from cellulosic biomass and in others from natural sugar sources, into renewable diesel and other fuels. Biodiesel companies convert vegetable oils and animal oils into diesel fuel and some are seeking to produce diesel and other transportation fuels using thermochemical methods to convert biomass into renewable fuels.
With the emergence of many new companies seeking to produce chemicals and fuels from alternative sources, we may face increasing competition from alternative fuels and chemicals companies. As they emerge, some of these companies may be able to establish production capacity and commercial partnerships to compete with us. If we are unable to establish production and sales channels that allow us to offer comparable products at attractive prices, we may not be able to compete effectively with these companies.
We believe the primary competitive factors in both the chemicals and fuels markets are:
product price;
product performance and other measures of quality;
infrastructure compatibility of products;
sustainability; and
dependability of supply. 
The oil companies, large chemical companies and well-established agricultural products companies with whom we compete are much larger than we are, have, in many cases, well developed distribution systems and networks for their products, have valuable historical relationships with the potential customers we are seeking to serve and have much more extensive sales and marketing programs in place to promote their products. In order to be successful, we must convince customers that our products are at least as effective as the traditional products they are seeking to replace and we must provide our products on a cost-competitive basis with these traditional products and other available alternatives. Some of our competitors may use their influence to impede the development and acceptance of renewable products of the type that we are seeking to produce.
We believe that for our chemical products to succeed in the market, we must demonstrate that our products are comparable

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alternatives to existing products and to any alternative products that are being developed for the same markets based on some combination of product cost, availability, performance, and consumer preference characteristics. With respect to our diesel and other transportation fuels products, we believe that our product must perform as effectively as petroleum-based fuel, or alternative fuels, and be available on a cost-competitive basis. In addition, with the wide range of renewable fuels products under development, we must be successful in reaching potential customers and convincing them that ours are effective and reliable alternatives.
A decline in the price of petroleum and petroleum-based products may reduce demand for many of our renewable products and may otherwise adversely affect our business.
We anticipate that most of our renewable products, and in particular our fuels, will be marketed as alternatives to corresponding petroleum-based products. If the price of oil falls, we may be unable to produce products that are cost-effective alternatives to petroleum-based products. Declining oil prices, or the perception of a future decline in oil prices, may adversely affect the prices we can obtain from our potential customers or prevent potential customers from entering into agreements with us to buy our products. During sustained periods of lower oil prices we may be unable to sell some of our products, which could materially and adversely affect our operating results.
 
Our pursuit of new product opportunities may not be technically feasible, which would limit our ability to expand our product line and sources of revenues.
In order to grow our business over time we will need to, and we intend to, commit substantial resources, alone or with collaboration partners, to the development and analysis of new molecules that can be produced using our technology, and the new pathways, or microbial strains, required to produce them. There is no guarantee that we will be successful in creating microbial strains that are capable of producing each target molecule or that the molecule can be produced with the required purity profile for a given market in a cost effective manner. For example, some target molecules may be “toxic” to the microbe, which means that the production of the molecule kills the microbe. Other molecules may be biologically producible in small amounts but cannot be produced in quantities adequate for commercial production. In addition, some of our microbes may have longer production cycles that may make production of the target molecules more costly. If we are unable to resolve issues of this nature, we may not be able to expand our product line to introduce new sources of future revenues.
Changes in government regulations, including subsidies and economic incentives, could have a material adverse effect upon our business.
The market for renewable fuels is heavily influenced by foreign, federal, state and local government regulations and policies. Changes to existing or adoption of new domestic or foreign federal, state and local legislative initiatives that impact the production, distribution or sale of renewable fuels may harm our renewable fuels business. In the U.S. and in a number of other countries, regulations and policies encouraging production and use of alternative fuels have been modified in the past and may be modified again in the future. Any reduction in mandated requirements for fuel alternatives and additives to gasoline or diesel may cause demand for biofuels to decline and deter investment in the research and development of renewable fuels. For example, in December 2011, the U.S. Congress did not renew legislation that extended tax credits to blenders of certain renewable fuel products and is not likely to renew them retroactively. The absence of tax credits, subsidies and other incentives in the U.S. and foreign markets for renewable fuels, or any inability of our customers to access such credits, subsidies and incentives, may adversely affect demand for our products and increase the overall cost of commercialization of our renewable fuels, which would adversely affect our renewable fuels business. In addition, in December 2011, a U.S. federal court found the State of California's Low Carbon Fuel Standard unconstitutional and the case is currently on appeal in the Ninth Circuit. An affirmation of this ruling could have a negative impact on demand for advanced renewable fuels. The resulting market uncertainty regarding this and future standards and policies may also affect our ability to develop new renewable products or to license our technologies to third parties and to sell products to our end customers. Any inability to address these requirements and any regulatory or policy changes could have a material adverse effect on our business, financial condition and results of operations.
Concerns associated with renewable fuels, including land usage, national security interests and food crop usage, continue to receive legislative, industry and public attention. This attention could result in future legislation, regulation and/or administrative action that could adversely affect our business. Any inability to address these requirements and any regulatory or policy changes could have a material adverse effect on our business, financial condition and results of operations.
Furthermore, the production of our products will depend on the availability of feedstock, especially sugarcane. Agricultural production and trade flows are subject to government policies and regulations. Governmental policies affecting the agricultural industry, such as taxes, tariffs, duties, subsidies, incentives and import and export restrictions on agricultural commodities and commodity products, can influence the planting of certain crops, the location and size of crop production, whether unprocessed or processed commodity products are traded, the volume and types of imports and exports, and the availability and competitiveness of feedstocks as raw materials. Future government policies may adversely affect the supply of feedstocks, restrict our ability to use sugarcane or other feedstocks to produce our products, and negatively impact our future revenues and results of operations.
 

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We may incur significant costs complying with environmental laws and regulations, and failure to comply with these laws and regulations could expose us to significant liabilities.
We use hazardous chemicals and radioactive and biological materials in our business and such materials are subject to a variety of federal, state and local laws and regulations governing the use, generation, manufacture, storage, handling and disposal of these materials both in the U.S. and overseas. Although we have implemented safety procedures for handling and disposing of these materials and related waste products in an effort to comply with these laws and regulations, we cannot be sure that our safety measures are compliant or capable of eliminating the risk of accidental injury or contamination from the use, storage, handling or disposal of hazardous materials. In the event of contamination or injury, we could be held liable for any resulting damages, and any liability could exceed our insurance coverage. There can be no assurance that violations of environmental, health and safety laws will not occur in the future as a result of human error, accident, equipment failure or other causes. Compliance with applicable environmental laws and regulations may be expensive, and the failure to comply with past, present, or future laws could result in the imposition of fines, third party property damage, product liability and personal injury claims, investigation and remediation costs, the suspension of production, or a cessation of operations, and our liability may exceed our total assets. Liability under environmental laws can be joint and several and without regard to comparative fault. Environmental laws could become more stringent over time, imposing greater compliance costs and increasing risks and penalties associated with violations, which could impair our research, development or production efforts and harm our business.
Our financial results could vary significantly from quarter to quarter and are difficult to predict.
Our revenues and results of operations could vary significantly from quarter to quarter because of a variety of factors, many of which are outside of our control. As a result, comparing our results of operations on a period-to-period basis may not be meaningful. Factors that could cause our quarterly results of operations to fluctuate include:
achievement, or failure, with respect to technology, product development or manufacturing milestones needed to allow us to enter identified markets on a cost effective basis;
delays or greater than anticipated expenses associated with the completion or commissioning of new production facilities, or the time to ramp up and stabilize production following completion of a new production facility;
impairment of assets based on shifting business priorities and working capital limitations;
disruptions in the production process at any manufacturing facility;
losses associated with producing our products as we ramp to commercial production levels;
failure to recover value added tax (VAT) that we currently reflect as recoverable in our financial statements (e.g., due to failure to meet conditions for reimbursement of VAT under local law);
the timing, size and mix of sales to customers for our products;
increases in price or decreases in availability of feedstock;
the unavailability of contract manufacturing capacity altogether or at reasonable cost;
fluctuations in foreign currency exchange rates;
gains or losses associated with our hedging activities;
fluctuations in the price of and demand for sugar, ethanol, and petroleum-based and other products for which our products are alternatives;
seasonal variability in production and sales of our products;
competitive pricing pressures, including decreases in average selling prices of our products;
unanticipated expenses associated with changes in governmental regulations and environmental, health and safety requirements;
reductions or changes to existing fuel and chemical regulations and policies;
departure of executives or other key management employees resulting in transition and severance costs;
our ability to use our net operating loss carry forwards to offset future taxable income;
business interruptions such as earthquakes and other natural disasters;
our ability to integrate businesses that we may acquire;
risks associated with the international aspects of our business; and

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changes in general economic, industry and market conditions, both domestically and in our foreign markets.
In addition, nearly all of our revenue to date has come from the sale of ethanol and reformulated ethanol-blended gasoline, with the remainder coming from collaborations and government grants and, more recently, sales of our renewable products. Effective in the third quarter of 2012, we transitioned out of the ethanol and reformulated ethanol-blended gasoline business. We do not expect to be able to replace much of the revenue lost in the near term as a result of this transition, particularly in 2012 and 2013 while we continue our efforts to establish a renewable products business.

As part of our operating plan for 2012, we have commenced reductions to, and expect to continue to reduce, our cost structure by improving efficiency in our operations and reducing non-critical expenditures. These efforts may include reductions to our workforce and adjustments to the timing and scope of planned capital expenditures in the coming quarters. Resulting headcount reductions to reduce operating expenses may result in reduced collaboration and government grant revenues to the extent that such headcount reductions reduce our ability to dedicate resources to activities funded by such collaborations and grants.

Due to the factors described above, among others, the results of any quarterly or annual period may not meet our expectations or the expectations of our investors and may not be meaningful indications of our future performance.
Disruption of transportation and logistics services or insufficient investment in public infrastructure could adversely affect our business.
We intend to conduct initial large-scale manufacturing of most of our renewable products in Brazil, where existing transportation infrastructure is relatively underdeveloped. Substantial investments required for infrastructure changes and expansions may not be made on a timely basis or at all. Any delay or failure in making the changes to or expansion of infrastructure could harm demand or prices for our renewable products or impose additional costs that would hinder their commercialization.
In Brazil, a substantial portion of commercial transportation is by truck, which is significantly more expensive than the rail transportation available to U.S. and certain other international producers. Our dependence on truck transport may affect our production cost and, consequently, impair our ability to compete with petroleum-sourced products in local and world markets.
Growth may place significant demands on our management and our infrastructure.
We have experienced, and expect to continue to experience, expansion of our business as we continue to make efforts to develop and bring our products to market. We have grown from 18 employees at the end of 2005 to 437 at September 30, 2012. We are working simultaneously on multiple projects to develop, produce and commercialize several types of renewable chemicals and fuels. Our growth and diversified operations have placed, and may continue to place, significant demands on our management and our operational and financial infrastructure. In particular, continued growth could strain our ability to:
manage multiple research and development programs;
operate multiple manufacturing facilities around the world;
develop and improve our operational, financial and management controls;
enhance our reporting systems and procedures;
recruit, train and retain highly skilled personnel;
develop and maintain our relationships with existing and potential business partners;
maintain our quality standards; and
maintain customer satisfaction.
 In addition, if our strategy or plans are unsuccessful, we may be forced to scale back our headcount and other aspects of our operating structure to maintain alignment with changing strategies. For example, as part of our operating plan for 2012, we have commenced reductions to, and expect to continue to reduce, our cost structure by improving efficiency in our operations and reducing non-critical expenditures.  These efforts may include reductions to our workforce and adjustments to the timing and scope of planned capital expenditures in the coming quarters.

Managing our growth will require significant expenditures and allocation of valuable management resources. If we fail to achieve the necessary level of efficiency in our organization as it grows, our business, results of operations and financial condition would be adversely impacted.
Our proprietary rights may not adequately protect our technologies and product candidates.

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Our commercial success will depend substantially on our ability to obtain patents and maintain adequate legal protection for our technologies and product candidates in the U.S. and other countries. As of October 31, 2012, we had 180 issued U.S. and foreign patents and 306 pending U.S. and foreign patent applications that were owned by or licensed to us. We will be able to protect our proprietary rights from unauthorized use by third parties only to the extent that our proprietary technologies and future products are covered by valid and enforceable patents or are effectively maintained as trade secrets.
We apply for patents covering both our technologies and product candidates, as we deem appropriate. However, we may fail to apply for patents on important technologies or product candidates in a timely fashion, or at all. Our existing and future patents may not be sufficiently broad to prevent others from practicing our technologies or from developing competing products or technologies. In addition, the patent positions of companies like ours are highly uncertain and involve complex legal and factual questions for which important legal principles remain unresolved. No consistent policy regarding the breadth of patent claims has emerged to date in the U.S. and the landscape is expected to become even more uncertain in view of recent rule changes by the Patent and Trademark Office, or USPTO, the introduction of patent reform legislation in Congress and recent decisions in patent law cases by the U.S. Supreme Court. In addition, we obtained certain key U.S. patents using a procedure for accelerated examination recently implemented by the USPTO which requires special activities and disclosures that may create additional risks related to the validity or enforceability of the U.S. patents so obtained. The patent situation outside of the U.S. is even less predictable. As a result, the validity and enforceability of patents cannot be predicted with certainty. Moreover, we cannot be certain whether:
we or our licensors were the first to make the inventions covered by each of our issued patents and pending patent applications;
we or our licensors were the first to file patent applications for these inventions;
others will independently develop similar or alternative technologies or duplicate any of our technologies;
any of our or our licensors' patents will be valid or enforceable;
any patents issued to us or our licensors will provide us with any competitive advantages, or will be challenged by third parties;
we will develop additional proprietary products or technologies that are patentable; or
the patents of others will have an adverse effect on our business.
We do not know whether any of our patent applications or those patent applications that we license will result in the issuance of any patents. Even if patents are issued, they may not be sufficient to protect our technology or product candidates. The patents we own or license and those that may be issued in the future may be challenged, invalidated, rendered unenforceable, or circumvented, and the rights granted under any issued patents may not provide us with proprietary protection or competitive advantages. In particular, U.S. patents we obtained using the USPTO accelerated examination program may introduce additional risks to the validity or enforceability of some or all of these specially-obtained U.S. patents if validity or enforceability are challenged. Moreover, third parties could practice our inventions in territories where we do not have patent protection or in territories where they could obtain a compulsory license to our technology where patented. Such third parties may then try to import products made using our inventions into the U.S. or other territories. Additional uncertainty may result from potential passage of patent reform legislation by the U.S. Congress, legal precedent by the U.S. Federal Circuit and Supreme Court as they determine legal issues concerning the scope and construction of patent claims and inconsistent interpretation of patent laws by the lower courts. Accordingly, we cannot ensure that any of our pending patent applications will result in issued patents, or even if issued, predict the breadth, validity and enforceability of the claims upheld in our and other companies' patents.
Unauthorized parties may attempt to copy or otherwise obtain and use our products or technology. Monitoring unauthorized use of our intellectual property is difficult, and we cannot be certain that the steps we have taken will prevent unauthorized use of our technology, particularly in certain foreign countries where the local laws may not protect our proprietary rights as fully as in the U.S. or may provide, today or in the future, for compulsory licenses. If competitors are able to use our technology, our ability to compete effectively could be harmed. Moreover, others may independently develop and obtain patents for technologies that are similar to, or superior to, our technologies. If that happens, we may need to license these technologies, and we may not be able to obtain licenses on reasonable terms, if at all, which could cause harm to our business.
 
We rely in part on trade secrets to protect our technology, and our failure to obtain or maintain trade secret protection could adversely affect our competitive business position.
We rely on trade secrets to protect some of our technology, particularly where we do not believe patent protection is appropriate or obtainable. However, trade secrets are difficult to maintain and protect. Our strategy for contract manufacturing and scale-up of commercial production requires us to share confidential information with our international business partners and other parties. Our product development collaborations with third parties, including with Total, require us to share confidential information, including with employees of Total who are seconded to Amyris during the term of the collaboration. While we use reasonable

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efforts to protect our trade secrets, our or our business partners' employees, consultants, contractors or scientific and other advisors may unintentionally or willfully disclose our proprietary information to competitors. Enforcement of claims that a third party has illegally obtained and is using trade secrets is expensive, time consuming and uncertain. In addition, foreign courts are sometimes less willing than U.S. courts to protect trade secrets. If our competitors independently develop equivalent knowledge, methods and know-how, we would not be able to assert our trade secrets against them.
We require new employees and consultants to execute confidentiality agreements upon the commencement of an employment or consulting arrangement with us. These agreements generally require that all confidential information developed by the individual or made known to the individual by us during the course of the individual's relationship with us be kept confidential and not disclosed to third parties. These agreements also generally provide that inventions conceived by the individual in the course of rendering services to us shall be our exclusive property. Nevertheless, our proprietary information may be disclosed, or these agreements may be unenforceable or difficult to enforce. Additionally, trade secret law in Brazil differs from that in the U.S. which requires us to take a different approach to protecting our trade secrets in Brazil. Some of these approaches to trade secret protection may be novel and untested under Brazilian law and we cannot guarantee that we would prevail if our trade secrets are contested in Brazil. If any of the above risks materializes, our failure to obtain or maintain trade secret protection could adversely affect our competitive business position.
Third parties may misappropriate our yeast strains.
Third parties, including contract manufacturers, sugar and ethanol mill owners, other contractors and shipping agents, often have custody or control of our yeast strains. If our yeast strains were stolen, misappropriated or reverse engineered, they could be used by other parties who may be able to reproduce the yeast strains for their own commercial gain. If this were to occur, it would be difficult for us to challenge and prevent this type of use, especially in countries where we have limited intellectual property protection or that do not have robust intellectual property law regimes.
If we are sued for infringing intellectual property rights or other proprietary rights of third parties, litigation could be costly and time consuming and could prevent us from developing or commercializing our future products.
Our commercial success depends on our ability to operate without infringing the patents and proprietary rights of other parties and without breaching any agreements we have entered into with regard to our technologies and product candidates. We cannot determine with certainty whether patents or patent applications of other parties may materially affect our ability to conduct our business. Our industry spans several sectors, including biotechnology, renewable fuels, renewable specialty chemicals and other renewable compounds, and is characterized by the existence of a significant number of patents and disputes regarding patent and other intellectual property rights. Because patent applications can take several years to issue, there may currently be pending applications, unknown to us, that may result in issued patents that cover our technologies or product candidates. We are aware of a significant number of patents and patent applications relating to aspects of our technologies filed by, and issued to, third parties. The existence of third-party patent applications and patents could significantly reduce the coverage of patents owned by or licensed to us and limit our ability to obtain meaningful patent protection. If we wish to make, use, sell, offer to sell, or import the technology or compound claimed in issued and unexpired patents owned by others, we will need to obtain a license from the owner, enter into litigation to challenge the validity of the patents or incur the risk of litigation in the event that the owner asserts that we infringe its patents. If patents containing competitive or conflicting claims are issued to third parties and these claims are ultimately determined to be valid, we may be enjoined from pursing research, development, or commercialization of products, or be required to obtain licenses to these patents, or to develop or obtain alternative technologies.
If a third-party asserts that we infringe upon its patents or other proprietary rights, we could face a number of issues that could seriously harm our competitive position, including:
infringement and other intellectual property claims, which could be costly and time consuming to litigate, whether or not the claims have merit, and which could delay getting our products to market and divert management attention from our business;
substantial damages for past infringement, which we may have to pay if a court determines that our product candidates or technologies infringe a third party's patent or other proprietary rights;
a court prohibiting us from selling or licensing our technologies or future products unless the holder licenses the patent or other proprietary rights to us, which it is not required to do; and
if a license is available from a third party, such third party may require us to pay substantial royalties or grant cross licenses to our patents or proprietary rights.
The industries in which we operate, and the biotechnology industry in particular, are characterized by frequent and extensive litigation regarding patents and other intellectual property rights. Many biotechnology companies have employed intellectual property litigation as a way to gain a competitive advantage. If any of our competitors have filed patent applications or obtained

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patents that claim inventions also claimed by us, we may have to participate in interference proceedings declared by the relevant patent regulatory agency to determine priority of invention and, thus, the right to the patents for these inventions in the U.S. These proceedings could result in substantial cost to us even if the outcome is favorable. Even if successful, an interference proceeding may result in loss of certain claims. Our involvement in litigation, interferences, opposition proceedings or other intellectual property proceedings inside and outside of the U.S., to defend our intellectual property rights or as a result of alleged infringement of the rights of others, may divert management time from focusing on business operations and could cause us to spend significant resources, all of which could harm our business and results of operations.
Many of our employees were previously employed at universities, biotechnology, specialty chemical or oil companies, including our competitors or potential competitors. We may be subject to claims that these employees or we have inadvertently or otherwise used or disclosed trade secrets or other proprietary information of their former employers. Litigation may be necessary to defend against these claims. If we fail in defending such claims, in addition to paying monetary damages, we may lose valuable intellectual property rights or personnel and be enjoined from certain activities. A loss of key research personnel or their work product could hamper or prevent our ability to commercialize our product candidates, which could severely harm our business. Even if we are successful in defending against these claims, litigation could result in substantial costs and demand on management resources.
We may need to commence litigation to enforce our intellectual property rights, which would divert resources and management's time and attention and the results of which would be uncertain.
Enforcement of claims that a third party is using our proprietary rights without permission is expensive, time consuming and uncertain. Significant litigation would result in substantial costs, even if the eventual outcome is favorable to us and would divert management's attention from our business objectives. In addition, an adverse outcome in litigation could result in a substantial loss of our proprietary rights and we may lose our ability to exclude others from practicing our technology or producing our product candidates.
The laws of some foreign countries do not protect intellectual property rights to the same extent as do the laws of the U.S. Many companies have encountered significant problems in protecting and defending intellectual property rights in certain foreign jurisdictions. The legal systems of certain countries, particularly certain developing countries, do not favor the enforcement of patents and other intellectual property protection, particularly those relating to biotechnology and/or bioindustrial technologies. This could make it difficult for us to stop the infringement of our patents or misappropriation of our other intellectual property rights. Proceedings to enforce our patent rights in foreign jurisdictions could result in substantial costs and divert our efforts and attention from other aspects of our business. Moreover, our efforts to protect our intellectual property rights in such countries may be inadequate.
We may be sued for product liability.
The design, development, production and sale of our products involve an inherent risk of product liability claims and the associated adverse publicity. Our potential products could be used by a wide variety of consumers with varying levels of sophistication. Although safety is a priority for us, we are not always in control of the final uses and formulations of the products we supply or their use as ingredients. Our products could have detrimental impacts or adverse impacts we cannot anticipate. Despite our efforts, negative publicity about Amyris, including product safety or similar concerns, whether real or perceived, could occur, and our products could face withdrawal, recall or other quality issues. In addition, we may be named directly in product liability suits relating to our products, even for defects resulting from errors of our commercial partners, contract manufacturers or chemical finishers. These claims could be brought by various parties, including customers who are purchasing products directly from us or other users who purchase products from our customers. We could also be named as co-parties in product liability suits that are brought against the contract manufacturers or Brazilian sugar and ethanol mills with whom we partner to produce our products. Insurance coverage is expensive, may be difficult to obtain and may not be available in the future on acceptable terms. We cannot be certain that our contract manufacturers or the sugar and ethanol producers who partner with us to produce our products will have adequate insurance coverage to cover against potential claims. Any insurance we do maintain may not provide adequate coverage against potential losses, and if claims or losses exceed our liability insurance coverage, our business would be adversely impacted. In addition, insurance coverage may become more expensive, which would harm our results of operations.
During the ordinary course of business, we may become subject to lawsuits or indemnity claims, which could materially and adversely affect our business and results of operations.
From time to time, we may in the ordinary course of business be named as a defendant in lawsuits, claims and other legal proceedings. These actions may seek, among other things, compensation for alleged personal injury, worker's compensation, employment discrimination, breach of contract, property damages, civil penalties and other losses of injunctive or declaratory relief. In the event that such actions or indemnities are ultimately resolved unfavorably at amounts exceeding our accrued liability, or at material amounts, the outcome could materially and adversely affect our reputation, business and results of operations. In addition, payments of significant amounts, even if reserved, could adversely affect our liquidity position.

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If we fail to maintain an effective system of internal controls, we might not be able to report our financial results accurately or prevent fraud; in that case, our stockholders could lose confidence in our financial reporting, which would harm our business and could negatively impact the price of our stock.
Effective internal controls are necessary for us to provide reliable financial reports and prevent fraud. In addition, Section 404 of the Sarbanes-Oxley Act of 2002 requires us and our independent registered public accounting firm to evaluate and report on our internal control over financial reporting. The process of implementing our internal controls and complying with Section 404 is expensive and time consuming, and requires significant attention of management. We cannot be certain that these measures will ensure that we maintain adequate controls over our financial processes and reporting in the future. In addition, to the extent we create joint ventures or have any variable interest entities and the financial statements of such entities are not prepared by us, we will not have direct control over their financial statement preparation. As a result, we will, for our financial reporting, depend on what these entities report to us, which could result in us adding monitoring and audit processes and increase the difficulty of implementing and maintaining adequate controls over our financial processes and reporting in the future. This may be particularly true where we are establishing such entities with commercial partners that do not have sophisticated financial accounting processes in place, or where we are entering into new relationships at a rapid pace, straining our integration capacity. Additionally, if we do not receive the information from the joint venture or variable interest entity on a timely basis, this could cause delays in our external reporting. Even if we conclude, and our independent registered public accounting firm concurs, that our internal control over financial reporting provides reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external purposes in accordance with generally accepted accounting principles, because of its inherent limitations, internal control over financial reporting may not prevent or detect fraud or misstatements. Failure to implement required new or improved controls, or difficulties encountered in their implementation, could harm our results of operations or cause us to fail to meet our reporting obligations. If we or our independent registered public accounting firm discover a material weakness, the disclosure of that fact, even if quickly remedied, could reduce the market's confidence in our financial statements and harm our stock price. In addition, failure to comply with Section 404 could subject us to a variety of administrative sanctions, including SEC action, ineligibility for short form resale registration, the suspension or delisting of our common stock from the stock exchange on which it is listed, and the inability of registered broker-dealers to make a market in our common stock, which would further reduce our stock price and could harm our business.
If the value of our goodwill or other intangible assets becomes impaired, it could materially reduce the value of our assets and reduce our net income for the year in which the related impairment charges occur.
We apply the applicable accounting principles set forth in the U.S. Financial Accounting Standards Board's Accounting Standards Codification to our intangible assets (including goodwill), which prohibits the amortization of intangible assets with indefinite useful lives and requires that these assets be reviewed for impairment at least annually. There are several methods that can be used to determine the estimated fair value of the in-process research and development acquired in a business combination. We have used the "income method," which applies a probability weighting that considers the risk of development and commercialization, to the estimated future net cash flows that are derived from projected sales revenues and estimated costs. These projections are based on factors such as relevant market size, pricing of similar products, and expected industry trends. The estimated future net cash flows are then discounted to the present value using an appropriate discount rate. These assets are treated as indefinite-lived intangible assets until completion or abandonment of the projects, at which time the assets will be amortized over the remaining useful life or written off, as appropriate. If the carrying amount of the assets is greater than the measures of fair value, impairment is considered to have occurred and a write-down of the asset is recorded. Any finding that the value of our intangible assets has been impaired would require us to write-down the impaired portion, which could reduce the value of our assets and reduce our net income for the year in which the related impairment charges occur.  As of September 30, 2012 , we had a net carrying value of approximately $9.1 million in in-process research and development and goodwill associated with our acquisition of Draths Corporation.
Our ability to use our net operating loss carry forwards to offset future taxable income may be subject to certain limitations.
In general, under Section 382 of the Internal Revenue Code, or Code, a corporation that undergoes an “ownership change” is subject to limitations on its ability to utilize its pre-change net operating loss carry forwards, or NOLs, to offset future taxable income. If the Internal Revenue Service challenges our analysis that our existing NOLs are not subject to limitations arising from previous ownership changes, or if we undergo an ownership change, our ability to utilize NOLs could be limited by Section 382 of the Code. Future changes in our stock ownership, some of which are outside of our control, could result in an ownership change under Section 382 of the Code. Furthermore, our ability to utilize NOLs of companies that we may acquire in the future may be subject to limitations. For these reasons, we may not be able to utilize a material portion of the NOLs reflected on our balance sheet, even if we attain profitability.
Loss of government contract revenues could impair our research and development efforts.
In 2010, we were awarded a $24.3 million “Integrated Bio-Refinery” grant from the U.S. Department of Energy, or DOE. The terms of this grant make funds available to us to leverage and expand our existing Emeryville, California, pilot plant and

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support laboratories to develop U.S.-based production capabilities for renewable fuels and chemicals derived from sweet sorghum. Generally, government grant agreements have fixed terms and may be terminated, modified or recovered by the granting agency under certain conditions. For example, our grant requires us to implement substantial reporting, governance and other processes to comply with the grant contract, and we are subject to audits and reviews by government agencies with respect to such compliance. We have limited experience in complying with such government contract requirements, and any compliance failures can result in additional audits, burdensome corrective action plans, and significant penalties, up to and including termination, modification and recovery of the grant by the granting agency. Our first DOE audit was performed in 2011 for the year ended December 31, 2010, and as a result of the audit we were required to implement a corrective action plan with respect to certain administrative requirements. We are subject to follow-on audits by the DOE from time to time to review our compliance and other matters.
In June 2012, we entered into a Technology Investment Agreement with The Defense Advanced Research Projects Agency (DARPA), under which we are performing certain research and development activities funded in part by DARPA. Under the agreement, we could receive funding of up to approximately $8.0 million over two years based on achievement of program milestones and would be responsible for contributions equivalent to approximately $900,000. We cannot be sure that we will receive the amount of funding available under the agreement. For example, we may not be able to meet the project milestones on a timely basis or at all. In addition, DARPA may determine that the project is not producing beneficial results commensurate with the expense, and seek to terminate the agreement in accordance with its terms.
If the DOE or DARPA terminate their agreements with us, in addition to reducing our revenues, our U.S.-based research and development activities could be impaired, which would harm our business.
Our headquarters and other facilities are located in an active earthquake zone, and an earthquake or other types of natural disasters affecting us or our suppliers could cause resource shortages and disrupt and harm our results of operations.
We conduct our primary research and development operations in the San Francisco Bay Area in an active earthquake zone, and certain of our suppliers conduct their operations in the same region or in other locations that are susceptible to natural disasters. In addition, California and some of the locations where certain of our suppliers are located have experienced shortages of water, electric power and natural gas from time to time. The occurrence of a natural disaster, such as an earthquake, drought or flood, or localized extended outages of critical utilities or transportation systems, or any critical resource shortages, affecting us or our suppliers could cause a significant interruption in our business, damage or destroy our facilities, production equipment or inventory or those of our suppliers and cause us to incur significant costs or result in limitations on the availability of our raw materials, any of which could harm our business, financial condition and results of operations. The insurance we maintain against fires, earthquakes and other natural disasters may not be adequate to cover our losses in any particular case.
Risks Related to Ownership of Our Common Stock
Our stock price may be volatile.
The market price of our common stock has been, and we expect it to continue to be, subject to significant volatility, and it has declined significantly from our initial public offering price. As of November 1, 2012, the reported closing price for our common stock on the NASDAQ Global Select Market was $2.63 . Market prices for securities of early stage companies have historically been particularly volatile. Such fluctuations could be in response to, among other things, the factors described in this “Risk Factors” section or elsewhere in this report, or other factors, some of which are beyond our control, such as:
fluctuations in our financial results or outlook or those of companies perceived to be similar to us;
changes in estimates of our financial results or recommendations by securities analysts;
changes in market valuations of similar companies;
changes in the prices of commodities associated with our business such as sugar, ethanol and petroleum;
changes in our capital structure, such as future issuances of securities or the incurrence of debt;
announcements by us or our competitors of significant contracts, acquisitions or strategic alliances;
regulatory developments in the U.S., Brazil, and/or other foreign countries;
litigation involving us, our general industry or both;
additions or departures of key personnel;
investors' general perception of us; and
changes in general economic, industry and market conditions.
Furthermore, stock markets have experienced price and volume fluctuations that have affected, and continue to affect, the

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market prices of equity securities of many companies. These fluctuations often have been unrelated or disproportionate to the operating performance of those companies. These broad market fluctuations, as well as general economic, political and market conditions, such as recessions, interest rate changes and international currency fluctuations, may negatively affect the market price of our common stock.
In the past, many companies that have experienced volatility and sustained declines in the market price of their stock have become subject to securities class action litigation. We may be the target of this type of litigation in the future. Securities litigation against us could result in substantial costs and divert our management's attention from other business concerns, which could seriously harm our business.
We are incurring increased costs and demands upon management as a result of complying with the laws and regulations affecting public companies, which could harm our results of operations.
As a public company, we are incurring significant additional accounting, legal and other expenses, including costs associated with public company reporting requirements. We also have incurred and will continue to incur costs associated with corporate governance requirements, including requirements under Section 404 and other provisions of the Sarbanes-Oxley Act, as well as rules implemented by the SEC and NASDAQ. The expenses incurred by public companies for reporting and corporate governance purposes have increased dramatically in recent years.
The concentration of our capital stock ownership with insiders will limit your ability to influence corporate matters.

As of September 30, 2012 , our executive officers and directors together beneficially owned (excluding options and other rights to acquire common stock) approximately 35.2% (as determined based on public filings with the SEC), and a single stockholder, Total, beneficially owned approximately 20.1%, of our outstanding common stock, respectively. This significant concentration of share ownership may adversely affect the trading price for our common stock because investors often perceive disadvantages in owning stock in companies with controlling stockholders. Also, these stockholders, acting together, will be able to control our management and affairs and matters requiring stockholder approval, including the election of directors and the approval of significant corporate transactions, such as mergers, consolidations or the sale of substantially all of our assets. Consequently, this concentration of ownership may have the effect of delaying or preventing a change of control, including a merger, consolidation or other business combination involving us, or discouraging a potential acquirer from making a tender offer or otherwise attempting to obtain control, even if that change of control would benefit our other stockholders.
If securities or industry analysts do not publish or cease publishing research or reports about us, our business or our market, or if they change their recommendations regarding our stock adversely, our stock price and trading volume could decline.
The trading market for our common stock will be influenced by the research and reports that industry or securities analysts may publish about us, our business, our market or our competitors. If any of the analysts who may cover us change their recommendation regarding our stock adversely, or provide more favorable relative recommendations about our competitors, our stock price would likely decline. If any analyst who may cover us were to cease coverage of our company or fail to regularly publish reports on us, we could lose visibility in the financial markets, which in turn could cause our stock price or trading volume to decline.
We do not expect to declare any dividends in the foreseeable future.
We do not anticipate declaring any cash dividends to holders of our common stock in the foreseeable future. In addition, certain of our equipment leases and credit facilities currently restrict our ability to pay dividends. Consequently, investors may need to rely on sales of their common stock after price appreciation, which may never occur, as the only way to realize any future gains on their investment. Investors seeking cash dividends should not purchase our common stock.
Anti-takeover provisions contained in our certificate of incorporation and bylaws, as well as provisions of Delaware law, could impair a takeover attempt.
Our amended and restated certificate of incorporation and our amended and restated bylaws that became effective upon the completion of our initial public offering contain provisions that could delay or prevent a change in control of our company. These provisions could also make it more difficult for stockholders to elect directors and take other corporate actions. These provisions include:
staggered board of directors;
authorizing the board to issue, without stockholder approval, preferred stock with rights senior to those of our common stock;
authorizing the board to amend our bylaws and to fill board vacancies until the next annual meeting of the stockholders;

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prohibiting stockholder action by written consent;
limiting the liability of, and providing indemnification to, our directors and officers;
not authorizing our stockholders to call a special stockholder meeting;
eliminating the ability of our stockholders to call special meetings; and
requiring advance notification of stockholder nominations and proposals. 
Section 203 of the Delaware General Corporation Law prohibits, subject to some exceptions, “business combinations” between a Delaware corporation and an “interested stockholder,” which is generally defined as a stockholder who becomes a beneficial owner of 15% or more of a Delaware corporation's voting stock, for a three-year period following the date that the stockholder became an interested stockholder. We have agreed to opt out of Section 203 through our certificate of incorporation, but our certificate of incorporation contains substantially similar protections to our company and stockholders as those afforded under Section 203, except that we have agreed with Total that it and its affiliates will not be deemed to be “interested stockholders” under such protections.
 
In addition, we have an agreement with Total, which provides that, so long as Total holds at least 10% of our voting securities, we must inform Total of any offer to acquire us or any decision of our Board of Directors to sell our company, and we must provide Total with information about the contemplated transaction. In such events, Total will have an exclusive negotiating period of 15 business days in the event the Board of Directors authorizes us to solicit offers to buy Amyris, or five business days in the event that we receive an unsolicited offer to purchase us. This exclusive negotiation period will be followed by an additional restricted negotiation period of 10 business days, during which we are obligated to continue to negotiate with Total and will be prohibited from entering into an agreement with any other potential acquirer.
 
These and other provisions in our amended and restated certificate of incorporation and our amended and restated bylaws that became effective upon the completion of our initial public offering under Delaware law and in our agreement with Total could discourage potential takeover attempts, reduce the price that investors might be willing to pay in the future for shares of our common stock and result in the market price of our common stock being lower than it would be without these provisions.


Item 2. Unregistered Sales of Equity Securities and Use of Proceeds

(a) Recent Sales of Unregistered Securities

In July and September 2012, we completed the sale of unsecured senior convertible promissory notes in an aggregate principal amount of $53.3 million pursuant to a purchase agreement with Total. Under the purchase agreement: (i) on July 30, 2012, we sold a 1.5% Senior Unsecured Convertible Note Due 2017 to Total in the face amount of $38.3 million, including $15.0 million in new funds and repayment by Amyris of $23.3 million in previously-provided diesel research and development funding by Total, and (ii) on September 14, 2012, we sold another note (in the same form) for $15.0 million in new funds from Total. (The purchase agreement provides that additional notes may be sold in subsequent closings in July 2013 (for cash proceeds to Amyris of $30.0 million) and July 2014 (for cash proceeds to Amyris of $21.7 million, which would be settled in an initial installment of $10.85 million payable at such closing and a second installment of $10.85 million payable in January 2015).

The notes each have a March 1, 2017 maturity date and a conversion price equal to $7.0682 per share of our common stock. The notes bear interest of 1.5% per year (with a default rate of 2.5%), accruing from date of funding and payable at maturity or on conversion or a change of control where Total exercises a right to require us to repay the notes. Accrued interest is canceled if the notes are canceled based on a decision by Total to proceed with the underlying program and joint venture (a "Go" decision as discussed in "Note 9 - Significant Agreements" in Part I, Item 1 of this report). The notes become convertible into our common stock (i) within 10 trading days prior to maturity (if they are not canceled as described above prior to their maturity date), (ii) on a change of control of Amyris, (iii) if Total is no longer the largest stockholder of Amyris following a “No-Go” decision (subject to a six-month lock-up with respect to any shares of common stock issued upon conversion), and (iv) on a default by Amyris. If Total makes a final “Go” decision, then the notes will be exchanged by Total for equity interests in the Fuels JV, after which the notes will not be convertible and any obligation to pay principal or interest on the notes will be extinguished. If Total makes a “No-Go” decision, outstanding notes will remain outstanding and become payable at maturity.

As of September 30, 2012, the notes were convertible into an aggregate of approximately 7,540,817 shares of our common stock. The conversion price of the notes is subject to adjustment for proportional adjustments to outstanding common stock and under anti-dilution provisions in case of certain dividends and distributions. Total has a right to require repayment of 101% of the principal amount of the notes in the event of a change of control of Amyris and the notes provide for payment of unpaid interest

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on conversion following such a change of control if Total does not require such repayment. The purchase agreement and notes include covenants regarding payment of interest, maintaining our listing status, limitations on debt, maintenance of corporate existence, and filing of SEC reports. The notes include standard events of default resulting in acceleration of indebtedness, including failure to pay, bankruptcy and insolvency, cross-defaults, and breaches of the covenants in the purchase agreement and notes, with added default interest rates and associated cure periods applicable to the covenant regarding SEC reporting.

No underwriters were involved in the foregoing sales of securities. The notes were issued in private transactions pursuant to Section 4(2) of the Securities Act. The recipient of notes acquired the securities for investment purposes only and without intent to resell, was able to fend for itself in these transactions, and was an accredited investor as defined in Rule 501 of Regulation D promulgated under Section 3(b) of the Securities Act, and appropriate restrictions were set out in the agreements for, and notes issued in, these transactions. This security holder had adequate access, through its relationship with us, to information about us.

ITEM 3. DEFAULTS UPON SENIOR SECURITIES

Not applicable.


ITEM 4. MINE SAFETY DISCLOSURES

Not applicable.

ITEM 5. OTHER INFORMATION

Not applicable.




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ITEM 6. EXHIBITS

The exhibits listed in Exhibit Index immediately preceding the exhibits are filed (other than exhibits 32.01, 32.02 and 101) as part of this Quarterly Report on Form 10-Q and such Exhibit Index is incorporated herein by reference.



SIGNATURE
Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned thereunto duly authorized.
 
 
 
AMYRIS, INC.
 
 
 
 
Dated:
November 8, 2012
By:
/ S /    J OHN  G. M ELO
 
 
 
John G. Melo
President and Chief Executive Officer
(Principal Executive Officer)
 
 
 
 
Dated:
November 8, 2012
By:
/ S /   STEVEN R. MILLS
 
 
 
STEVEN R. MILLS
Chief Financial Officer
(Principal Financial and Accounting Officer)



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EXHIBIT INDEX
 
Exhibit
Index
 
 
 
Previously Filed
 
Filed
Herewith
Description
 
Form
  
File No.
 
Filing Date
  
Exhibit
 
 
 
 
 
 
 
 
 
 
 
 
 
 
3.01
 
Restated Certificate of Incorporation
 
10-Q
 
001-34885
 
November 10, 2010
 
3.01
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
3.02
 
Restated Bylaws
 
10-Q
 
001-34885
 
November 10, 2010
 
3.02
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
4.01
 
Securities Purchase Agreement, dated July 30, 2012, between registrant and Total Gas & Power USA, SAS
 
 
 
 
 
 
 
 
 
X
 
 
 
 
 
 
 
 
 
 
 
 
 
4.02 a
 
1.5% Senior Unsecured Convertible Notes, dated July 30, 2012 and September 14, 2012, respectively, issued by registrant to Total Gas & Power USA, SAS
 
 
 
 
 
 
 
 
 
X
 
 
 
 
 
 
 
 
 
 
 
 
 
4.03
 
Registration Rights Agreement, dated July 30, 2012, between registrant and Total Gas & Power USA, SAS
 
 
 
 
 
 
 
 
 
X
 
 
 
 
 
 
 
 
 
 
 
 
 
10.01 bc
 
Note of Bank Credit, dated July 13, 2012, between Amyris Brasil Ltda. and Nossa Caixa Desenvolvimento
 
 
 
 
 
 
 
 
 
X
 
 
 
 
 
 
 
 
 
 
 
 
 
10.02 bc
 
Note of Bank Credit, dated July 13, 2012, between Amyris Brasil Ltda. and Banco Pine S.A.
 
 
 
 
 
 
 
 
 
X
 
 
 
 
 
 
 
 
 
 
 
 
 
10.03 c
 
Fiduciary Conveyance of Movable Goods Agreement, dated July 13, 2012, among Amyris Brasil Ltda., Nossa Caixa Desenvolvimento and Banco Pine S.A.
 
 
 
 
 
 
 
 
 
X
 
 
 
 
 
 
 
 
 
 
 
 
 
10.04
 
Corporate Guarantee, dated July 13, 2012, issued by registrant to Nossa Caixa Desenvolvimento
 
 
 
 
 
 
 
 
 
X
 
 
 
 
 
 
 
 
 
 
 
 
 
10.05
 
Corporate Guarantee, dated July 13, 2012, issued by registrant to Banco Pine S.A.
 
 
 
 
 
 
 
 
 
X
 
 
 
 
 
 
 
 
 
 
 
 
 
10.06 b
 
Master Framework Agreement, dated July 30, 2012, between registrant and Total Gas & Power USA, SAS
 
 
 
 
 
 
 
 
 
X
 
 
 
 
 
 
 
 
 
 
 
 
 


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Exhibit
Index
 
 
 
Previously Filed
 
Filed
Herewith
Description
 
Form

File No.

Filing Date

Exhibit
 
 
 
 
 
 
 
 
 
 
 
 
 
 
10.07 b
 
Second Amendment to the Technology License, Development, Research and Collaboration Agreement, dated July 30, 2012, between registrant and Total Gas & Power USA, SAS
 
 
 
 
 
 
 
 
 
X
 
 
 
 
 
 
 
 
 
 
 
 
 
31.01
 
Certification of Chief Executive Officer pursuant to Securities Exchange Act Rules 13a-14(c) and 15d-14(a), as adopted pursuant to Section 302 of the Sarbanes-Oxley Act of 2002
 
 
 
 
 
 
 
 
 
X
 
 
 
 
 
 
 
 
 
 
 
 
 
31.02
 
Certification of Chief Financial Officer pursuant to Securities Exchange Act Rules 13a-14(c) and 15d-14(a), as adopted pursuant to Section 302 of the Sarbanes-Oxley Act of 2002
 
 
 
 
 
 
 
 
 
X
 
 
 
 
 
 
 
 
 
 
 
 
 
32.01 d
 
Certification of Chief Executive Officer pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002
 
 
 
 
 
 
 
 
 
X
 
 
 
 
 
 
 
 
 
 
 
 
 
32.02 d
 
Certification of Chief Financial Officer pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002
 
 
 
 
 
 
 
 
 
X
 
 
 
 
 
 
 
 
 
 
 
 
 
101 e
 
The following materials from registrant's Quarterly Report on Form 10-Q for the fiscal quarter ended September 30, 2012, formatted in XBRL(Extensible Business Reporting Language): (i) the Condensed Consolidated Statements of Operations; (ii) the Condensed Consolidated Balance Sheets; (iii) the Condensed Consolidated Statements of Comprehensive Loss; (iv) the Condensed Consolidated Statements of Stockholder's Equity; (v) the Condensed Consolidated Statement of Cash Flows; and (vi) Notes to Unaudited Condensed Consolidated Financial Statements
 
 
 
 
 
 
 
 
 
X
 
 
 
 
 
 
 
 
 
 
 
 
 
                                                      

a.
Registrant issued substantially identical 1.5% Senior Unsecured Convertible Notes (the “Notes”) to Total Gas & Power USA, SAS on separate dates. Registrant has filed the first of the Notes (numbered R-1), and has included, with Exhibit 4.02, a schedule (Schedule A to Exhibit 4.02) identifying each of the Notes and setting forth the material details in which the other Note(s) differ from the filed Note (i.e., the dates of issuance and the amounts of the Notes).
b.
Portions of this exhibit have been omitted pending a determination by the Securities and Exchange Commission as to whether these portions should be granted confidential treatment.
c.
Translation to English from Portuguese in accordance with Rule 12b-12(d) of the regulations promulgated by the Securities and Exchange Commission under the Securities Exchange Act of 1934, as amended (the “Exchange Act”).

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d.
This certification shall not be deemed “filed” for purposes of Section 18 of the Exchange Act or otherwise subject to the liability of that Section, nor shall it be deemed incorporated by reference into any filing under the Securities Act of 1933, as amended (the “Securities Act”) or the Exchange Act.
e.
Pursuant to applicable securities laws and regulations, registrant is deemed to have complied with the reporting obligation relating to the submission of interactive data files in such exhibits and is not subject to liability under any anti-fraud provisions of the federal securities laws as long as registrant has made a good faith attempt to comply with the submission requirements and promptly amends the interactive data files after becoming aware that the interactive data files fails to comply with the submission requirements. These interactive data files are deemed not filed or part of a registration statement or prospectus for purposes of Sections 11 or 12 of the Securities Act, are deemed not filed for purposes of Section 18 of the Exchange Act and otherwise are not subject to liability under these sections.


95



EXECUTION DRAFT

SECURITIES PURCHASE AGREEMENT
This SECURITIES PURCHASE AGREEMENT (this “ Agreement ”) is made and entered into as of July 30, 2012, by and between Amyris, Inc., a Delaware corporation (the “ Company ”), and Total Gas & Power USA, SAS, a société par actions simplifiée organized under the laws of the Republic of France (the “ Purchaser ”).
BACKGROUND
(A)
The Company and Purchaser are parties to that certain Technology License, Development, Research and Collaboration Agreement, entered into as of June 21, 2010, as amended by the First Amendment entered into as of November 23, 2011 (the “ Current Collaboration Agreement ”), which provides for certain research and development projects under the Amyris-Total Renewable Farnesene Development Project Plan (the “ Project Plan ”) between the Company and Purchaser.

(B)
Contemporaneously with the execution of this Agreement, the Company and Purchaser will enter into the Second Amendment to the Current Collaboration Agreement (the “ Second Amendment ”, and the Current Collaboration Agreement, as so amended, the “ Collaboration Agreement ”).

(C)
Contemporaneously with the execution of this Agreement, the Company and the Purchaser will execute and deliver a Master Framework Agreement, dated as of July 30, 2012, by and between the Company and the Purchaser (the “ Master Framework Agreement ”).

(D)
The Company and Purchaser are executing and delivering this Agreement in reliance upon the exemption from registration afforded by Section 4(2) of the Securities Act of 1933, (the “ Securities Act ”), and Rule 506 of Regulation D (“ Regulation D ”) as promulgated by the United States Securities and Exchange Commission (the “ SEC ”) under the Securities Act.

(E)
The Purchaser desires to purchase, and the Company desires to offer and sell to the Purchaser, up to an aggregate of $105,000,000 in principal amount of its 1.5% Senior Unsecured Convertible Notes due 2017 (individually a “ Security ” and collectively the “ Securities ”) at the Initial Closing and at any Subsequent Closing (each as hereinafter defined). The Securities will be evidenced by Convertible Notes in the form attached hereto as Exhibit A . The Securities will be convertible into shares (the “ Underlying Securities ”) of the Company's common stock, $0.0001 par value per share (the “ Common Stock ”), in accordance with the terms of the Securities.

Agreement
The parties, intending to be legally bound, agree as follows:

1



ARTICLE 1
SALE OF SECURITIES

1.1.     Purchase and Sale of Securities .

(a) Initial Closing . Subject to the terms and conditions hereof, at the Initial Closing the Company will sell to the Purchaser, and the Purchaser will purchase from the Company, a Security in the principal amount of Fifty-Three Million Three Hundred Thousand Dollars ($53,300,000), of which Thirty Million Dollars ($30,000,000) shall be paid by the Purchaser in cash in two equal installments of Fifteen Million Dollars ($15,000,000) as specified in Section 2.1(a) below, and of which Twenty-Three Million Three Hundred Thousand Dollars ($23,300,000) shall be retained by the Purchaser pursuant to Section 8.4 (collectively, the “ Initial Closing Purchase Price ”).

(b) Second Closing . Subject to the terms and conditions hereof, at the Second Closing the Company will sell to the Purchaser, and the Purchaser will purchase from the Company, a Security in the principal amount of Thirty Million Dollars ($30,000,000) (the “ Second Closing Purchase Price ”).

(c) Third Closing . Subject to the terms and conditions hereof, at the Third Closing the Company will sell to the Purchaser, and the Purchaser will purchase from the Company, a Security in the principal amount of Twenty-One Million Seven Hundred Thousand Dollars ($21,700,000), which amount shall be paid by the Purchaser in cash in two equal installments of Ten Million Eight Hundred Fifty Thousand Dollars ($10,850,000) as specified in Section 2.1(c) below (the “ Third Closing Purchase Price ”, with each of the Initial Closing Purchase Price, any Second Closing Purchase Price and any Third Closing Purchase Price being referred to herein as a “ Purchase Price ”).

ARTICLE 2
CLOSING; DELIVERY

2.1.     Closing .

(a) Initial Closing . The closing of the purchase and sale of the first Fifty-Three Million Three Hundred Thousand Dollars ($53,300,000) in principal amount of Securities by and to the Purchaser hereunder (the “ Initial Closing ”) shall be held at the offices of Shearman & Sterling LLP, Four Embarcadero Center, Suite 3800, San Francisco, California  94111-5994 within one business day following the date on which the last of the conditions set forth in Section 5.1 and Section 6.1 (other than those conditions that by their nature are to be satisfied at the Initial Closing), have been satisfied or waived in accordance with this Agreement but in no event later than July 31, 2012 (such date, the “ Initial Closing Date ”), or at such other time and place as the Company and the Purchaser mutually agree upon. The settlement of the purchase and sale of the Securities to be purchased and sold at the Initial Closing shall take place in two installments, with the first installment in the principal amount of Thirty-Eight Million Three Hundred Thousand Dollars ($38,300,000) occurring on the Initial Closing Date, such amount to be paid in the manner specified in Sections 5.1(a) and Section 8.4 below, and the second installment in the principal amount of Fifteen Million Dollars ($15,000,000) occurring on September 15, 2012.


2



(b) Second Closing . The closing of the purchase and sale of the second Thirty Million Dollars ($30,000,000) in principal amount of Securities, if any, by and to the Purchaser hereunder (the “ Second Closing ”) shall be held at the offices of Shearman & Sterling LLP, Four Embarcadero Center, Suite 3800, San Francisco, California  94111-5994 within one business day following the date on which the last of the conditions set forth in Section 5.2 and Section 6.2 applicable to any Second Closing (other than those conditions that by their nature are to be satisfied at any Second Closing) have been satisfied or waived in accordance with this Agreement but in no event later than July 31, 2013 (such date, the “ Second Closing Date ”), or at such other time and place as the Company and the Purchaser mutually agree upon. The settlement of the purchase and sale of the Securities to be purchased and sold at the Second Closing shall take place in a single installment occurring on the Second Closing Date.

(c) Third Closing . The closing of the purchase and sale of the third Twenty-One Million Seven Hundred Thousand Dollars ($21,700,000) in principal amount of Securities, if any, by and to the Purchaser hereunder (the “ Third Closing ”, with each of the Initial Closing, any Second Closing and any Third Closing being referred to herein as a “ Closing ”, and each of any Second Closing and any Third Closing being referred to herein as a “ Subsequent Closing ”) shall be held at the offices of Shearman & Sterling LLP, Four Embarcadero Center, Suite 3800, San Francisco, California  94111-5994 within one business day following the date on which the last of the conditions set forth in Section 6.2 and Section 7.2 applicable to any Third Closing (other than those conditions that by their nature are to be satisfied at any Third Closing) have been satisfied or waived in accordance with this Agreement but in no event later than July 31, 2014 (such date, the “ Third Closing Date ”, with each of the Initial Closing Date, any Second Closing Date and any Third Closing Date being referred to herein as a “ Closing Date ”, and each of any Second Closing Date and any Third Closing Date being referred to herein as a “ Subsequent Closing Date ”), or at such other time and place as the Company and the Purchaser mutually agree upon. The settlement of the purchase and sale of the Securities to be purchased and sold at the Third Closing shall take place in two installments, with the first installment in the principal amount of Ten Million Eight Hundred Fifty Thousand Dollars ($10,850,000) occurring on the Third Closing Date, and the second installment in the principal amount of Ten Million Eight Hundred Fifty Thousand Dollars ($10,850,000) occurring on the date that is six (6) months following any Third Closing Date but in no event later than January 31, 2015.

2.2.     Delivery .

2.2.1    In each installment under each Closing hereunder, subject to the terms and conditions hereof to be satisfied at the applicable Closing Date, the Company will deliver to the Purchaser the Security to be purchased by and sold to the Purchaser in the applicable installment, in the name of the Purchaser, duly executed by the Company. At the Initial Closing, the Company shall execute and deliver to the Purchaser the Registration Rights Agreement in the form attached hereto as Exhibit B (“ Rights Agreement ”) and the other documents referenced in Section 6.1 . In the first installment under each Subsequent Closing, the Company shall execute and deliver to the Purchaser the documents referenced in Section 6.2 .

2.2.2    In each installment under each Closing hereunder, subject to the terms and conditions hereof to be satisfied at the applicable Closing Date, the Purchaser will deliver to the Company the Purchase Price for the Security to be purchased by and sold to the Purchaser in the

3



applicable installment by wire transfer of immediately available funds to such account or accounts as the Company shall designate in writing to the Purchaser at least two business days prior to the applicable Closing Date. At the Initial Closing, the Purchaser shall execute and deliver to the Company the Rights Agreement and the other documents referenced in Section 5.1 . In the first installment under each Subsequent Closing, the Purchaser shall execute and deliver to the Company the documents referenced in Section 5.2 .

ARTICLE 3
REPRESENTATIONS AND WARRANTIES OF THE COMPANY

The Company represents, warrants and covenants to the Purchaser, except as set forth in the disclosure letter supplied by the Company to the Purchaser dated as of the date hereof (in the case of the Initial Closing), as of the Second Closing Date (in the case of the Second Closing), or as of the Third Closing Date (in the case of the Third Closing), which exceptions shall be deemed to be part of the representations and warranties made hereunder as provided therein, as follows:
3.1.     Organization and Standing . The Company and each of its subsidiaries is duly incorporated, validly existing, and in good standing under the laws of the jurisdiction of its organization. Each of the Company and its subsidiaries has all requisite power and authority to own and operate its respective properties and assets and to carry on its respective business as presently conducted and as proposed to be conducted. The Company and each of its subsidiaries is qualified to do business as a foreign entity in every jurisdiction in which the failure to be so qualified would have, or would reasonably be expected to have, a material adverse effect, individually or in the aggregate, upon the business, properties, tangible and intangible assets, liabilities, operations, prospects, financial condition or results of operation of the Company and its subsidiaries or the ability of the Company or any of its subsidiaries to perform their respective obligations under the Transaction Agreements (as defined below) (a “ Material Adverse Effect ”).

3.2.     Subsidiaries . As used in this Agreement, references to any “subsidiary” of a specified Person shall refer to an Affiliate controlled by such Person directly, or indirectly through one or more intermediaries, as such terms are used in and construed under Rule 405 under the Securities Act (which, for the avoidance of doubt, shall include the Company's controlled joint ventures, including shared-controlled joint ventures). The Company's subsidiaries as of the date hereof are listed on Exhibit 21.01 to the Company's Annual Report on Form 10-K for the year ended December 31, 2011 and, except as Previously Disclosed (as defined in Section 3.10 ) are the only subsidiaries, direct or indirect, of the Company as of the date hereof. All the issued and outstanding shares of each subsidiary's capital stock have been duly authorized and validly issued, are fully paid and nonassessable, have been issued in compliance with all federal and state securities laws, were not issued in violation of or subject to any preemptive rights or other rights to subscribe for or purchase securities, and, except as Previously Disclosed, are owned by the Company or a Company subsidiary free and clear of all liens, encumbrances and equities and claims. As used herein, “ Person ” shall mean any individual, corporation, limited liability company, partnership, joint venture, association, joint-stock company, trust, unincorporated organization or government or any agency or political subdivision thereof, and an “ Affiliate ” means, with respect to any Person, any other Person which directly or indirectly controls, is controlled by, or is under common control with, such Person .


4



3.3.     Power . The Company has all requisite power to execute and deliver this Agreement, to sell and issue the Securities hereunder, and to carry out and perform its obligations under the terms of this Agreement, the Rights Agreement and the Securities (together, the “ Transaction Agreements ”).

3.4.     Authorization . The execution, delivery, and performance of the Transaction Agreements by the Company has been duly authorized by all requisite action on the part of the Company and its officers, directors and stockholders, and the Transaction Agreements constitute the legal, valid, and binding obligations of the Company enforceable in accordance with their terms, except (a) as limited by applicable bankruptcy, insolvency, reorganization, moratorium, and other laws of general application affecting enforcement of creditors' rights generally, and (b) as limited by laws relating to the availability of specific performance, injunctive relief or other equitable remedies (together, the “ Enforceability Exceptions ”).

3.5.     Consents and Approvals . Except for any Current Report on Form 8-K or Notice of Exempt Offering of Securities on Form D to be filed by the Company in connection with the transactions contemplated hereby, the Company is not required to give any notice to, make any filing with, or obtain any authorization, consent, or approval of any government or governmental agency in order to consummate the transactions contemplated by the Transaction Agreements. No consent, approval, authorization or other order of, or registration, qualification or filing with, any court, regulatory body, administrative agency, self-regulatory organization, stock exchange or market (including The NASDAQ Stock Market), or other governmental body is required for the execution and delivery of these Transaction Agreements, the valid, sale and delivery of the Securities to be sold pursuant to this Agreement other than such as have been made or obtained, or for any securities filings required to be made under federal or state securities laws applicable to the offering of the Securities.

3.6.     Non-Contravention . The execution and delivery of the Transaction Agreements, the issuance, sale and delivery of the Securities (including the issuance of the Underlying Securities upon conversion thereof) to be sold by the Company under this Agreement, the performance by the Company of its obligations under the Transaction Agreements and/or the consummation of the transactions contemplated thereby will not (a) conflict with, result in the breach or violation of, or constitute (with or without the giving of notice or the passage of time or both) a violation of, or default under, (i) any bond, debenture, note or other evidence of indebtedness, or under any lease, license, franchise, permit, indenture, mortgage, deed of trust, loan agreement, joint venture or other agreement or instrument to which the Company or any subsidiary is a party or by which it or its properties may be bound or affected, (ii) the Company's Restated Certificate of Incorporation, as amended and as in effect on the date hereof (the “ Certificate of Incorporation ”), the Company's Bylaws, as amended and as in effect on the date hereof (the “ Bylaws ”), or the equivalent document with respect to any subsidiary, as amended and as in effect on the date hereof, or (iii) any statute or law, judgment, decree, rule, regulation, ordinance or order of any court or governmental or regulatory body (including The NASDAQ Stock Market), governmental agency, arbitration panel or authority applicable to the Company, any of its subsidiaries or their respective properties, except in the

5



case of clauses (i) and (iii) for such conflicts, breaches, violations or defaults that would not be likely to have, individually or in the aggregate, a Material Adverse Effect, or (b) result in the creation or imposition of any lien, encumbrance, claim, security interest or restriction whatsoever upon any of the material properties or assets of the Company or any of its subsidiaries or an acceleration of indebtedness pursuant to any obligation, agreement or condition contained in any material bond, debenture, note or any other evidence of indebtedness or any material indenture, mortgage, deed of trust or any other agreement or instrument to which the Company or any if its subsidiaries is a party or by which the Company or any of its subsidiaries is bound or to which any of the property or assets of the Company is subject. For purposes of this Section 3.6 , the term “material” shall apply to agreements, understandings, instruments, contracts or proposed transactions to which the Company is a party or by which it is bound involving obligations (contingent or otherwise) of, or payments to, the Company in excess of $100,000 in a consecutive 12-month period.

3.7.     The Securities . The Securities have been duly authorized by the Company and, when duly executed and delivered and paid for as provided herein, will be duly and validly issued and outstanding and will constitute valid and legally binding obligations of the Company enforceable against the Company in accordance with their terms, subject to the Enforceability Exceptions.

3.8.     The Underlying Securities . Upon issuance and delivery of the Securities in accordance with this Agreement, the Securities will be convertible into shares of the Underlying Securities in accordance with the terms of the Securities; the Underlying Securities reserved for issuance upon conversion of the Securities have been duly authorized and reserved and, when issued upon conversion of the Securities in accordance with the terms of the Securities, will be validly issued, fully paid and non‑assessable, and the issuance of the Underlying Securities will not be subject to any preemptive or similar rights.

3.9.     No Registration . Assuming the accuracy of each of the representations and warranties of the Purchaser herein, the issuance by the Company of the Securities (including the issuance of the Underlying Securities upon conversion thereof) is exempt from registration under the Securities Act of 1933, as amended (the “ Securities Act ”).

3.10.     Reporting Status . The Company is subject to the reporting requirements of the Securities Exchange Act of 1934, as amended (the “ Exchange Act ”), and has, in a timely manner, filed all documents and reports that the Company was required to file pursuant to Section I.A.3.b of the General Instructions to Form S-3 promulgated under the Securities Act in order for the Company to be eligible to use Form S-3 for the two years preceding the Initial Closing Date (in the case of the Initial Closing), the Second Closing Date (in the case of the Second Closing), or the Third Closing Date (in the case of the Third Closing), or such shorter time period as the Company has been subject to such reporting requirements (the foregoing materials, together with any materials filed by the Company under the Exchange Act, whether or not required, collectively, the “ SEC Documents ”). The SEC Documents complied as to form in all material respects with requirements of the Securities Act and Exchange Act and the rules and regulations of the U.S. Securities and Exchange Commission (the “ SEC ”) promulgated thereunder (collectively, the “ SEC Rules ”), and none of the SEC Documents and the information contained therein, as of their respective filing dates, contained any untrue statement of a material

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fact or omitted to state a material fact required to be stated therein or necessary in order to make the statements therein, in light of the circumstances under which they were made, not misleading. As used in this Agreement, “ Previously Disclosed ” means information set forth in or incorporated by reference into the SEC Documents filed with the SEC on or after February 28, 2012 but prior to the Business Day immediately prior to the date hereof (in the case of the Initial Closing), the Business Day immediately prior to the Second Closing Date (in the case of the Second Closing), or the Business Day immediately prior to the Third Closing Date (in the case of the Third Closing) (except for risks and forward-looking information set forth in the “Risk Factors” section of the applicable SEC Documents or in any forward-looking statement disclaimers or similar statements that are similarly non-specific and are predictive or forward-looking in nature). The Company is eligible to register the Underlying Securities for resale by the Purchaser using Form S-3 promulgated under the Securities Act.

3.11.     Contracts . Each indenture, contract, lease, mortgage, deed of trust, note agreement, loan or other agreement or instrument of a character that is required to be described or summarized in the SEC Documents or to be filed as an exhibit to the SEC Documents under the SEC Rules (collectively, the “ Material Contracts ”) is so described, summarized or filed. The Material Contracts to which the Company or its subsidiaries are a party have been duly and validly authorized, executed and delivered by the Company and constitute the legal, valid and binding agreements of the Company or its subsidiaries, as applicable, enforceable by and against the Company or its subsidiaries, as applicable, in accordance with their respective terms, subject to the Enforceability Exceptions

3.12.     Capitalization . Immediately prior to the Initial Closing, the authorized capital stock of the Company consists of (a) 100,000,000 shares of Common Stock, $0.0001 par value per share, 58,739,226 shares of which are issued and outstanding as of the date hereof, and (b) 5,000,000 shares of Preferred Stock, $0.0001 par value per share, of which no shares were issued and outstanding. All subscriptions, warrants, options, convertible securities, and other rights (contingent or other) to purchase or otherwise acquire equity securities of the Company issued and outstanding as of the date hereof, or material contracts, commitments, understandings, or arrangements by which the Company or any of its subsidiaries is or may be obligated to issue shares of capital stock, or securities or rights convertible or exchangeable for shares of capital stock, are as set forth in the SEC Documents. The issued and outstanding shares of the Company's capital stock have been duly authorized and validly issued, are fully paid and nonassessable, have been issued in compliance with all applicable federal and state securities laws, and were not issued in violation of or subject to any preemptive rights or other rights to subscribe for or purchase securities. Except as Previously Disclosed, no holder of the Company's capital stock is entitled to preemptive or similar rights. The Company has delivered to the Purchaser copies of all agreements to which the Company is a party related to the Company's securities with any securityholder of the Company , other than (i) any agreement with Purchaser, (ii) any agreement which has been filed as an exhibit to the SEC Documents, and (iii) any agreement related to employee equity grants or awards. There are no bonds, debentures, notes or other indebtedness having general voting rights (or convertible into securities having such rights) of the Company issued and outstanding. Except as Previously Disclosed, there are no agreements or arrangements under which the Company or any of its subsidiaries is obligated to register the sale of any of their securities under the Securities Act. The Company has made available to the Purchaser a true, correct and complete copy of the Company's Certificate of Incorporation and Bylaws.

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3.13.     Legal Proceedings . Except as Previously Disclosed, there is no action, suit or proceeding before any court, governmental agency or body, domestic or foreign, now pending or, to the knowledge of the Company, threatened against the Company or its subsidiaries wherein an unfavorable decision, ruling or finding would reasonably be expected to, individually or in the aggregate, (i) materially adversely affect the validity or enforceability of, or the authority or ability of the Company to perform its obligations under this Agreement or (ii) have a Material Adverse Effect. The Company is not a party to or subject to the provisions of any injunction, judgment, decree or order of any court, regulatory body, administrative agency or other governmental agency or body that might have, individually or in the aggregate, a Material Adverse Effect.

3.14.     No Violations .

(a) Neither the Company nor any of its subsidiaries is in violation of its respective certificate of incorporation, bylaws or other organizational documents, or to its knowledge, is in violation of any statute or law, judgment, decree, rule, regulation, ordinance or order of any court or governmental or regulatory body (including The NASDAQ Stock Market), governmental agency, arbitration panel or authority applicable to the Company or any of its subsidiaries, which violation, individually or in the aggregate, would be reasonably likely to have a Material Adverse Effect. Neither the Company nor any of its subsidiaries is in default (and there exists no condition which, with or without the passage of time or giving of notice or both, would constitute a default) in the performance of any bond, debenture, note or any other evidence of indebtedness in any indenture, mortgage, deed of trust or any other material agreement or instrument to which the Company or any of its subsidiaries is a party or by which the Company or any of its subsidiaries is bound or by which the properties of the Company are bound, which would be reasonably likely to have a Material Adverse Effect. There has not been, and to the knowledge of the Company, there is not pending or contemplated, any investigation by the SEC involving the Company or any current or former director or officer of the Company and the Company is not an “ineligible issuer” pursuant to Rules 164, 405 and 433 under the Securities Act. The Company has not received any comment letter from the SEC relating to any SEC Documents which has not been finally resolved. The SEC has not issued any stop order or other order suspending the effectiveness of any registration statement filed by the Company under the Exchange Act or the Securities Act.

(b) The Company is not in default (and there exists no condition which, with or without the passage of time or giving of notice or both, would constitute a default) in the performance of any outstanding Securities.

3.15.     Governmental Permits; FDA Matters .

(a) Permits . The Company and its subsidiaries possess all necessary franchises, licenses, certificates and other authorizations from any foreign, federal, state or local government or governmental agency, department or body that are currently necessary for the operation of their respective businesses as currently conducted, except where such failure to

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possess would not reasonably be expected to have, individually or in the aggregate, a Material Adverse Effect. Neither the Company nor any of its subsidiaries has received any notice of proceedings relating to the revocation or modification of any such permit which, if the subject of an unfavorable decision, ruling or finding, could reasonably be expected to have, individually or in the aggregate, a Material Adverse Effect.

(b) EPA and FDA Matters . As to each of the manufacturing processes, intermediate products and research or commercial products of the Company and each of its subsidiaries, including, without limitation, products or compounds currently under research and/or development by the Company, subject to the jurisdiction of the United States Environmental Protection Agency (“ EPA ”) under the Toxic Substances Control Act and regulations thereunder (“ TSCA ”) or the Food and Drug Administration (“ FDA ”) under the Federal Food, Drug and Cosmetic Act and the regulations thereunder (“ FDCA ”) (each such product, a “ Life Science Product ”), such Life Science Product is being researched, developed, manufactured, tested, distributed and/or marketed in compliance in all material respects with all applicable requirements under the FDCA and TSCA and similar laws and regulations applicable to such Life Science Product, including those relating to investigational use, premarket approval, good manufacturing practices, labeling, advertising, record keeping, filing of reports and security. The Company has not received any notice or other communication from the FDA, EPA or any other federal, state or foreign governmental entity (i) contesting the premarket approval of, the uses of or the labeling and promotion of any Life Science Product or (ii) otherwise alleging any violation by the Company of any law, regulation or other legal provision applicable to a Life Science Product. Neither the Company, nor any officer, employee or agent of the Company has made an untrue statement of a material fact or fraudulent statement to the FDA or other federal, state or foreign governmental entity performing similar or equivalent functions or failed to disclose a material fact required to be disclosed to the FDA or such other federal, state or foreign governmental entity.

3.16.     Listing Compliance . The Company is in compliance with the requirements of the NASDAQ Global Select Market for continued listing of the Common Stock thereon and has no knowledge of any facts or circumstances that could reasonably lead to delisting of its Common Stock from the NASDAQ Global Select Market. The Company has taken no action designed to, or likely to have the effect of, terminating the registration of the Common Stock under the Exchange Act or the listing of the Common Stock on the NASDAQ Global Select Market, nor has the Company received any notification that the SEC or the NASDAQ Global Select Market is contemplating terminating such registration or listing. The transactions contemplated by the Transaction Agreements will not contravene the rules and regulations of the NASDAQ Global Select Market. The Company will comply with all requirements of the NASDAQ Global Select Market with respect to the issuance of the Securities (including the issuance of the Underlying Securities upon conversion thereof), including the filing of any additional listing notice with respect to the issuance of the Securities (including the issuance of the Underlying Securities upon conversion thereof).

3.17.     Intellectual Property .

(a) The Company and/or the subsidiaries owns or possesses, free and clear of all encumbrances, all legal rights to all intellectual property and industrial property rights and

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rights in confidential information, including all (i) patents, patent applications, invention disclosures, and all related continuations, continuations-in-part, divisional, reissues, re‑examinations, substitutions and extensions thereof, (ii) trademarks, trademark rights, service marks, service mark rights, corporate names, trade names, trade name rights, domain names, logos, slogans, trade dress, design rights, and other similar designations of source or origin, together with the goodwill symbolized by and of the foregoing, (iii) trade secrets and all other confidential information, ideas, know-how, inventions, proprietary processes, formulae, models, and other methodologies, (iv) copyrights, (v) computer programs (whether in object code, subject code or other form), algorithms, databases, compilations and data, technology supporting the foregoing, and all related documentation, (vi) licenses to any of the foregoing, and (vii) all applications and registrations of the foregoing, and (viii) all other similar proprietary rights (collectively, “ Intellectual Property ”) used or held for use in, or necessary for the conduct of their businesses as now conducted and as proposed to be conducted, and neither the Company nor any of its subsidiaries (i) has received any communications alleging that either the Company or any of the subsidiaries has violated, infringed or misappropriated or, by conducting their businesses as now conducted and as proposed to be conducted, would violate, infringe or misappropriate any of the Intellectual Property of any other Person, (ii) knows of any basis for any claim that the Company or any of the subsidiaries has violated, infringed or misappropriated, or, by conducting their businesses as now conducted and as proposed to be conducted, would violate, infringe or misappropriate any of the Intellectual Property of any other Person, and (iii) knows of any third‑party infringement, misappropriation or violation of any Company or any Company subsidiary's Intellectual Property. The Company has taken and takes reasonable security measures to protect the secrecy, confidentiality and value of its Intellectual Property, including requiring all Persons with access thereto to enter into appropriate non-disclosure agreements. To the knowledge of the Company, there has not been any disclosure of any material trade secret of the Company or a Company subsidiary (including any such information of any other Person disclosed in confidence to the Company) to any other Person in a manner that has resulted or is likely to result in the loss of trade secret in and to such information. Except as Previously Disclosed, and except as would not reasonably be expected to have, individually or in the aggregate, a Material Adverse Effect, there are no outstanding options, licenses or agreements, claims, encumbrances or shared ownership interests of any kind relating to the Company's or the subsidiaries' Intellectual Property, nor is the Company or the subsidiaries bound by or a party to any options, licenses or agreements of any kind with respect to the Intellectual Property of any other Person.

(b) To the Company's knowledge, none of the employees of the Company or the subsidiaries are obligated under any contract (including, without limitation, licenses, covenants or commitments of any nature or contracts entered into with prior employers), or subject to any judgment, decree or order of any court or administrative agency, that would interfere with the use of his or her best efforts to promote the interests of the Company or the subsidiaries or would conflict with their businesses as now conducted and as proposed to be conducted. Neither the execution nor delivery of the Transaction Agreements will conflict with or result in a breach of the terms, conditions or provisions of, or constitute a default under any contract, covenant or instrument under which the Company or the subsidiaries or any of the employees of the Company or the subsidiaries is now obligated, and neither the Company nor the subsidiaries will need to use any inventions that any of its employees, or persons it currently intends to employ, have made prior to their employment with the Company or the subsidiaries,

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except for inventions that have been assigned or licensed to the Company or the subsidiaries as of the applicable Closing Date. Each current and former employee or contractor of the Company or the subsidiaries that has developed any Intellectual Property owned or purported to be owned by the Company or the subsidiaries has executed and delivered to the Company a valid and enforceable Invention Assignment and Confidentiality Agreement that (i) assigns to the Company or such subsidiaries all right, title and interest in and to any Intellectual Property rights arising from or developed or delivered to the Company or such subsidiaries in connection with such person's work for or on behalf of the Company or such subsidiaries, and (ii) provides reasonable protection for the trade secrets, know-how and other confidential information (1) of the Company or such subsidiaries and (2) of any third party that has disclosed same to the Company or such subsidiaries. To the knowledge of the Company, no current or former employee, officer, consultant or contractor is in default or breach of any term of any employment, consulting or contractor agreement, non-disclosure agreement, assignment agreement, or similar agreement. Except as Previously Disclosed, to the knowledge of the Company, no present or former employee, officer, consultant or contractor of the Company has any ownership, license or other right, title or interest, directly or indirectly, in whole or in part, in any Intellectual Property that is owned or purported to be owned, in whole or part, by the Company or the subsidiaries.

3.18.     Financial Statements . The consolidated financial statements of the Company and its subsidiaries and the related notes thereto included in the SEC Documents (the “ Financial Statements ”) comply in all material respects with applicable accounting requirements and the rules and regulations of the SEC with respect thereto as in effect at the time of filing and present fairly, in all material respects, the financial position of the Company and its subsidiaries as of the dates indicated and the results of its operations and cash flows for the periods therein specified subject, in the case of unaudited statements, to normal year-end audit adjustments. Except as set forth in such Financial Statements (or the notes thereto), such Financial Statements (including the related notes) have been prepared in accordance with U.S. generally accepted accounting principles applied on a consistent basis throughout the periods therein specified (“ GAAP ”). Except as set forth in the Financial Statements, neither the Company nor the subsidiaries has any material liabilities other than liabilities and obligations that have arisen in the ordinary course of business and which would not be required to be reflected in financial statements prepared in accordance with GAAP.

3.19.     Accountants . PricewaterhouseCoopers LLP (with respect to the Initial Closing) or any “Big Four” or “Second Six” independent audit firm then engaged by the Company (with respect to any Subsequent Closing), which has expressed its opinion with respect to the consolidated financial statements contained in the Company's Annual Report on Form 10-K for the year ended December 31, 2011 (with respect to the Initial Closing), December 31, 2012 (with respect to the Second Closing), or December 31, 2013 (with respect to the Third Closing), are, or with respect to the Second Closing and Third Closing will be at the time of the issuance of the applicable opinion, registered independent public accountants as required by the Exchange Act and the rules and regulations promulgated thereunder (and by the rules of the Public Company Accounting Oversight Board). In the case of the Initial Closing, as of the date hereof, the Company does not expect that the disclosure to be included in the Company's Quarterly Report on Form 10-Q for the three months ended June 30, 2012 in Note 1 of Notes to Unaudited Condensed Consolidated Financial Statements and under the headings “Management's Discussion and Analysis of Financial Condition and Results of Operations - Overview - Liquidity” and “Management's

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Discussion and Analysis of Financial Condition and Results of Operations - Liquidity and Capital Resources” will be materially different with respect to the Company's need for additional funds than such disclosure as was provided under such headings in the Company's Quarterly Report on Form 10-Q for the three months ended March 31, 2012, and in the case of each Subsequent Closing, as of the date of such Subsequent Closing, the Company does not expect that the disclosure to be included in the Company's Quarterly Report on Form 10-Q for the three month quarterly reporting period ended immediately prior to such Subsequent Closing in Note 1 of Notes to Unaudited Condensed Consolidated Financial Statements and under the headings “Management's Discussion and Analysis of Financial Condition and Results of Operations - Overview - Liquidity” and “Management's Discussion and Analysis of Financial Condition and Results of Operations - Liquidity and Capital Resources” will be materially different with respect to the Company's need for additional funds than such disclosure as was provided under such headings in the Company's most recently filed Quarterly Report on Form 10-Q.

3.20.     Internal Accounting Controls . The Company maintains a system of internal accounting controls sufficient to provide reasonable assurances that (i) transactions are executed in accordance with management's general or specific authorizations; (ii) transactions are recorded as necessary to permit preparation of financial statements in conformity with GAAP and to maintain accountability for assets; (iii) access to assets is permitted only in accordance with management's general or specific authorization; and (iv) the recorded accountability for assets is compared with existing assets at reasonable intervals and appropriate action is taken with respect to any differences. The Company has disclosure controls and procedures (as defined in Rules 13a-14 and 15d-14 under the Exchange Act) that are effective and designed to ensure that (i) information required to be disclosed in the reports that it files or submits under the Exchange Act is recorded, processed, summarized and reported, within the time periods specified by the SEC Rules, and (ii) such information is accumulated and communicated to the Company's management, including its principal executive officer and principal financial officer, to allow timely decisions regarding required disclosure. The Company is otherwise in compliance in all material respects with all applicable provisions of the Sarbanes-Oxley Act of 2002, as amended and the rules and regulations promulgated thereunder.

3.21.     Off-Balance Sheet Arrangements . There is no transaction, arrangement or other relationship between the Company or its subsidiaries and an unconsolidated or other off‑balance sheet entity that is required to be disclosed by the Company in its Exchange Act filings and is not so disclosed or that otherwise would be reasonably likely to have, individually or in the aggregate, a Material Adverse Effect. There are no such transactions, arrangements or other relationships with the Company that may create contingencies or liabilities that are not otherwise disclosed by the Company in its Exchange Act filings.

3.22.     No Material Adverse Change . Except as set forth in the SEC Documents in each case, filed or made through and including the applicable Closing Date, since December 31, 2011 (with respect to the Initial Closing), December 31, 2012 (with respect to the Second Closing), or December 31, 2013 (with respect to the Third Closing):

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(a) there has not been any event, occurrence or development that, individually or in the aggregate, has had or that could reasonably be expected to result in a Material Adverse Effect,

(b) the Company has not incurred any liabilities (contingent or otherwise) other than (1) trade payables and accrued expenses incurred in the ordinary course of business consistent with past practice and (2) liabilities not required to be reflected in the Company's financial statements pursuant to GAAP or not required to be disclosed in filings made with the SEC,

(c) the Company has not declared or made any dividend or distribution of cash or other property to its stockholders or purchased, redeemed or made any agreements to purchase or redeem any shares of its capital stock other than routine withholding in accordance with the Company's existing stock-based plan,

(d) the Company has not altered its method of accounting or the identity of its auditors, except as Previously Disclosed,

(e) the Company has not issued any equity securities except (i) pursuant to the Company's existing stock-based plans, or (ii) as otherwise Previously Disclosed; and

(f) there has not been any loss or damage (whether or not insured) to the physical property of the Company or any of its subsidiaries.

3.23.     Solvency . The Company is not as of the date hereof, and after giving effect to the transactions contemplated hereby to occur at the applicable Closing (assuming for this purpose that, in the case of the Initial Closing and the Third Closing, the payment to be made in the second installment of such Closing was instead made concurrent with such Closing), will not be Insolvent (as defined below). For purposes of this Section, “ Insolvent ” means, with respect to any Person, (i) the present fair saleable value of such Person's assets is less than the amount required to pay such Person's total indebtedness, (ii) such Person is unable to pay its debts and liabilities, subordinated, contingent or otherwise, as such debts and liabilities become absolute and matured, (iii) such Person intends to incur or believes that it will incur debts that would be beyond its ability to pay as such debts mature or (iv) such Person has unreasonably small capital with which to conduct the business in which it is engaged as such business is now conducted and is currently proposed to be conducted.

3.24.     No Manipulation of Stock . Neither the Company nor any of its subsidiaries, nor to the Company's knowledge, any of their respective officers, directors, employees, Affiliates or controlling Persons has taken and will not, in violation of applicable law, take, any action designed to or that might reasonably be expected to, directly or indirectly, cause or result in stabilization or manipulation of the price of the Common Stock.

3.25.     Insurance . The Company and its subsidiaries are insured by insurers of recognized financial responsibility against such losses and risks and in such amounts as are prudent and customary in the businesses in which the Company and the subsidiaries are engaged. The Company and its subsidiaries will continue to maintain such insurance or substantially similar insurance, which covers the same risks at the same levels as the existing insurance with

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insurers which guarantee the same financial responsibility as the current insurers, and neither the Company nor any subsidiary has any reason to believe that it will not be able to renew its existing insurance coverage as and when such coverage expires or to obtain similar coverage from similar insurers as may be necessary to continue its business without a significant increase in cost.

3.26.     Properties . The Company and its subsidiaries have good and marketable title to all the properties and assets (both tangible and intangible) described as owned by them in the consolidated financial statements included in the SEC Documents, free and clear of all liens, mortgages, pledges, or encumbrances of any kind except (i) those, if any, reflected in such consolidated financial statements (including the notes thereto), or (ii) those that are not material in amount and do not adversely affect the use made and proposed to be made of such property by the Company or its subsidiaries. The Company and each of its subsidiaries hold their leased properties under valid and binding leases. The Company and each of its subsidiaries own or lease all such properties as are necessary to its operations as now conducted.

3.27.     Tax Matters . The Company and the subsidiaries have filed all Tax Returns, and these Tax Returns are true, correct, and complete in all material respects. The Company and each subsidiary (i) have paid all Taxes that are due from the Company or such subsidiary for the periods covered by the Tax Returns or (ii) have duly and fully provided reserves adequate to pay all Taxes in accordance with GAAP. No agreement as to indemnification for, contribution to, or payment of Taxes exists between the Company or any subsidiary, on the one hand, and any other Person, on the other, including pursuant to any Tax sharing agreement, lease agreement, purchase or sale agreement, partnership agreement or any other agreement not entered into in the ordinary course of business. Neither the Company nor any of its subsidiaries has any liability for Taxes of any Person (other than the Company or any of its subsidiaries) under Treasury Regulation Section 1.1502-6 (or any similar provision of any state, local or foreign law), or as a transferee or successor, by contract or otherwise. Since the date of the Company's most recent Financial Statements, the Company has not incurred any liability for Taxes other than in the ordinary course of business consistent with past practice. Neither the Company nor the subsidiaries has been advised (a) that any of its Tax Returns have been or are being audited as of the date hereof, or (b) of any deficiency in assessment or proposed judgment to its Taxes. Neither the Company nor any of its subsidiaries has knowledge of any Tax liability to be imposed upon its properties or assets as of the date of this Agreement that is not adequately provided for. The Company has not distributed stock of another corporation, or has had its stock distributed by another corporation, in a transaction that was governed, or purported or intended to be governed, in whole or in part, by Section 355 of the Internal Revenue Code (i) in the two years prior to the date of this Agreement or (ii) in a distribution that could otherwise constitute part of a “plan” or “series of related transactions” (within the meaning of Section 334(e) of the Internal Revenue Code) in conjunction with the purchase of the Securities. “ Tax ” or “ Taxes ” means any foreign, federal, state or local income, gross receipts, license, payroll, employment, excise, severance, stamp, occupation, premium, property, windfall, profits, environmental, customs, capital stock, franchise, employees' income withholding, foreign or domestic withholding, social security, unemployment, disability, real property, personal property, sales, use, transfer, value added, alternative or add-on minimum or other similar tax, governmental fee, governmental assessment or governmental charge, including any interest, penalties or additions to Taxes or additional amounts with respect to the foregoing.

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Tax Returns ” means all returns, reports, or statements required to be filed with respect to any Tax (including any elections, notifications, declarations, schedules or attachments thereto, and any amendment thereof) including any information return, claim for refund, amended return or declaration of estimated Tax.

3.28.     Investment Company Status . The Company is not, and immediately after receipt of payment for the Securities will not be, an “investment company,” an “affiliated person” of, “promoter” for or “principal underwriter” for, or an entity “controlled” by an “investment company,” within the meaning of the Investment Company Act of 1940, as amended, or the rules and regulations promulgated thereunder.

3.29.     Transactions With Affiliates and Employees . Except as Previously Disclosed, none of the officers or directors of the Company or its subsidiaries and, to the knowledge of the Company, none of the employees of the Company or its subsidiaries is presently a party to any transaction with the Company or any subsidiary (other than for services as employees, officers and directors required to be disclosed under Item 404 of Regulation S-K under the Exchange Act).

3.30.     Foreign Corrupt Practices . Neither the Company nor its subsidiaries or Affiliates, any director or officer, nor to the knowledge of the Company, any agent, employee or other Person acting on behalf of the Company or its subsidiaries has, in the course of its actions for, or on behalf of, the Company or any of its subsidiaries (a) used any corporate funds for any unlawful contribution, gift, entertainment or other unlawful expenses relating to political activity, (b) made or promised to make any direct or indirect unlawful payment to any foreign or domestic government official or employee (including any officer or employee of a government or government-owned or controlled entity or of a public international organization, or any person acting in an official capacity for or on behalf of any of the foregoing, or of any political party or part official or candidate for political office (each such person, a “ Government Official ”)) from corporate funds, (c) violated or is in violation of any provision of the U.S. Foreign Corrupt Practices Act of 1977, as amended or (d) made or promised to make any unlawful bribe, rebate, payoff, influence payment, kickback or other unlawful payment to any foreign or domestic Government Official.

3.31.     Money Laundering Laws . The operations of the Company and its subsidiaries are and have been conducted at all times in compliance with applicable financial record-keeping and reporting requirements of the Currency and Foreign Transactions Reporting Act of 1970, as amended, and the Bank Secrecy Act, as amended by Title III of the Uniting and Strengthening America by Providing Appropriate Tools Required to Intercept and Obstruct Terrorism Act of 2001 (Title III of Pub. L. 107-56 (signed into law on October 26, 2001)), applicable money laundering statutes and applicable rules and regulations thereunder (collectively, the “ Money Laundering Laws ”), and no action, suit or proceeding by or before any court or governmental agency, authority or body or any arbitrator involving the Company or any of its subsidiaries with respect to the Money Laundering Laws is pending or, to the Company's knowledge, threatened.

3.32.     OFAC . Neither the Company, any director or officer, nor, to the Company's knowledge, any agent, employee, subsidiary or Affiliate of the Company is currently

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subject to any U.S. sanctions administered by the Office of Foreign Assets Control of the U.S. Treasury Department (“ OFAC ”); and the Company will not directly or indirectly use the proceeds of the offering, or lend, contribute or otherwise make available such proceeds to any subsidiary, joint venture partner or other Person, for the purpose of financing the activities of any Person currently subject to any U.S. sanctions administered by OFAC.

3.33.     Environmental Laws . The Company and its subsidiaries (i) are in compliance with any and all applicable foreign, federal, state and local laws and regulations relating to the protection of human health and safety, the environment or hazardous or toxic substances or wastes, pollutants or contaminants (“ Environmental Laws ”), (ii) have received all permits, licenses or other approvals required of them under applicable Environmental Laws to conduct their respective businesses and (iii) are in compliance with all terms and conditions of any such permit, license or approval, except where such noncompliance with Environmental Laws, failure to receive required permits, licenses or other approvals or failure to comply with the terms and conditions of such permits, licenses or approvals would not, singly or in the aggregate, have a Material Adverse Effect on the Company and its subsidiaries, taken as a whole. There are no costs or liabilities associated with Environmental Laws (including, without limitation, any capital or operating expenditures required for clean-up, closure of properties or compliance with Environmental Laws or any permit, license or approval, any related constraints on operating activities and any potential liabilities to third parties) which would, singly or in the aggregate, have a Material Adverse Effect on the Company and its subsidiaries, taken as a whole.

3.34.     Employee Relations . Neither the Company nor any of its subsidiaries is a party to any collective bargaining agreement or employs any member of a union. Neither the Company nor any of its subsidiaries is engaged in any unfair labor practice. There is (i) (x) no unfair labor practice complaint pending or, to the Company's knowledge, threatened against the Company or any of its subsidiaries before the National Labor Relations Board, and no grievance or arbitration proceeding arising out of or under collective bargaining agreements is pending or threatened, (y) no strike, labor dispute, slowdown or stoppage pending or, to the Company's knowledge, threatened against the Company or any of its subsidiaries and (z) no union representation dispute currently existing concerning the employees of the Company or any of its subsidiaries, and (ii) to the Company's knowledge, (x) no union organizing activities are currently taking place concerning the employees of the Company or any of its subsidiaries and (y) there has been no violation of any federal, state, local or foreign law relating to discrimination in the hiring, promotion or pay of employees or any applicable wage or hour laws. No executive officer of the Company (as defined in Rule 501(f) promulgated under the Securities Act) has notified the Company that such officer intends to leave the Company or otherwise terminate such officer's employment with the Company. No executive officer of the Company, to the knowledge of the Company, is, or is now expected to be, in violation of any material term of any employment contract, confidentiality, disclosure or proprietary information agreement, non-competition agreement, or any other agreement or any restrictive covenant, and the continued employment of each such executive officer does not subject the Company or any of its subsidiaries to any liability with respect to any of the foregoing matters.

3.35.     ERISA . The Company and its subsidiaries are in compliance in all material respects with all presently applicable provisions of the Employee Retirement Income Security Act of 1974, as amended, including the regulations and published interpretations

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thereunder (herein called “ ERISA ”); no “reportable event” (as defined in ERISA) has occurred with respect to any “pension plan” (as defined in ERISA) for which the Company or any of its subsidiaries would have any liability; the Company has not incurred and does not expect to incur liability under (i) Title IV of ERISA with respect to termination of, or withdrawal from, any “pension plan”; or (ii) Sections 412 or 4971 of the Internal Revenue Code of 1986, as amended, including the regulations and published interpretations thereunder (the “ Code ”); and each “Pension Plan” for which the Company would have liability that is intended to be qualified under Section 401(a) of the Code is so qualified in all material respects and nothing has occurred, whether by action or by failure to act, which would cause the loss of such qualification.

3.36.     Obligations of Management . To the Company's knowledge, each officer and key employee of the Company or the subsidiaries is currently devoting substantially all of his or her business time to the conduct of the business of the Company or the subsidiaries, respectively. The Company is not aware that any officer or key employee of the Company or the subsidiaries is planning to work less than full time at the Company or the subsidiaries, respectively, in the future. To the Company's knowledge, no officer or key employee is currently working or plans to work for a competitive enterprise, whether or not such officer or key employee is or will be compensated by such enterprise. To the Company's knowledge, no officer or person currently nominated to become an officer of the Company or the subsidiaries is or has been subject to any judgment or order of, the subject of any pending civil or administrative action by the SEC or any self-regulatory organization .

3.37.     Integration; Other Issuances of Securities . Neither the Company nor its subsidiaries or any Affiliates, nor any Person acting on its or their behalf, has issued any shares of Common Stock or shares of any series of preferred stock or other securities or instruments convertible into, exchangeable for or otherwise entitling the holder thereof to acquire shares of Common Stock which would be integrated with the sale of the Securities to the Purchaser at the applicable Closing for purposes of the Securities Act or of any applicable stockholder approval provisions, including, without limitation, under the rules and regulations of The NASDAQ Stock Market, nor will the Company or its subsidiaries or Affiliates take any action or steps that would require registration of any of the Securities under the Securities Act or cause the offering of the Securities at the applicable Closing to be integrated with other offerings if any such integration would cause the issuance of the Securities hereunder at the applicable Closing to fail to be exempt from registration under the Securities Act as provided in Section 3.9 above or cause the transactions contemplated hereby to contravene the rules and regulations of the NASDAQ Global Select Market.

3.38.     No General Solicitation . Neither the Company nor its subsidiaries or any Affiliates, nor any Person acting on its or their behalf, has offered or sold any of the Securities by any form of general solicitation or general advertising.

3.39.     No Brokers' Fees . The Company has not incurred any liability for any finder's or broker's fee or agent's commission in connection with the execution and delivery of this Agreement or the consummation of the transactions contemplated hereby.

3.40.     Registration Rights . Except as set forth in (i) the Amended and Restated Investors' Rights Agreement dated June 21, 2010, by and between the Company and the parties

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listed on Exhibits A through G thereof, as amended by Amendment Number 1 thereto dated as of February 23, 2012, (ii) the Registration Rights Agreement dated February 27, 2012, by and among the Company and the several purchasers signatory thereto and (iii) the Rights Agreement, the Company has not granted or agreed to grant to any Person any rights (including “piggy-back” registration rights) to have any securities of the Company registered with the SEC or any other governmental authority that have not been satisfied or waived.

3.41.     Application of Takeover Protections . There is no control share acquisition, business combination, poison pill (including any distribution under a rights agreement) or other similar anti-takeover provision under the Company's charter documents or the laws of its state of incorporation that is or could become applicable to the Purchaser as a result of the Purchaser and the Company fulfilling their obligations or exercising their rights under the Transaction Agreements, including, without limitation, as a result of the Company's issuance of the Securities (including the issuance of the Underlying Securities upon conversion thereof) and the Purchaser's ownership of the Securities.

3.42.     Disclosure . The Company understands and confirms that the Purchaser will rely on the foregoing representations in effecting transactions in the Securities. All disclosure furnished by or on behalf of the Company to the Purchaser in connection with this Agreement, the Second Amendment and the Master Framework Agreement regarding the Company, its business and the transactions contemplated hereby and thereby is true and correct in all material respects and does not contain any untrue statement of a material fact or omit to state any material fact necessary in order to make the statements made therein, in light of the circumstances under which they were made, not misleading.

ARTICLE 4
REPRESENTATIONS AND WARRANTIES OF THE PURCHASER

The Purchaser represents, warrants and covenants to the Company with respect to this purchase as follows:
4.1.     Organization . The Purchaser is duly organized, validly existing, and in good standing under the laws of the jurisdiction of its organization.

4.2.     Power . The Purchaser has all requisite power to execute and deliver this Agreement and to carry out and perform its obligations under the terms of this Agreement.

4.3.     Authorization . The execution, delivery, and performance of this Agreement by the Purchaser has been duly authorized by all requisite action, and this Agreement constitutes the legal, valid, and binding obligation of the Purchaser enforceable in accordance with its terms, except (a) as limited by applicable bankruptcy, insolvency, reorganization, moratorium, and other laws of general application affecting enforcement of creditors' rights generally, and (b) as limited by laws relating to the availability of specific performance, injunctive relief or other equitable remedies.

4.4.     Consents and Approvals . The Purchaser need not give any notice to, make any filing with, or obtain any authorization, consent, or approval of any government or governmental agency in order to consummate the transactions contemplated by this Agreement.


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4.5.     Non-Contravention . Neither the execution and the delivery of this Agreement, nor the consummation of the transactions contemplated hereby, will violate in any material respect any constitution, statute, regulation, rule, injunction, judgment, order, decree, ruling, charge, or other restriction of any government, governmental agency, or court to which the Purchaser is subject. No approval, waiver, or consent by the Purchaser under any instrument, contract, or agreement to which the Purchaser or any of its Affiliates is a party is necessary to consummate the transactions contemplated hereby.

4.6.     Purchase for Investment Only . The Purchaser is purchasing the Securities for the Purchaser's own account for investment purposes only and not with a view to, or for resale in connection with, any “distribution” in violation of the Securities Act. By executing this Agreement, the Purchaser further represents that it does not have any contract, undertaking, agreement, or arrangement with any Person to sell, transfer, or grant participation to such Person or to any third Person, with respect to any of the Securities. The Purchaser understands that the Securities have not been registered under the Securities Act or any applicable state securities laws by reason of a specific exemption therefrom that depends upon, among other things, the bona fide nature of the investment intent as expressed herein.

4.7.     Disclosure of Information . The Purchaser has had an opportunity to review the Company's filings under the Securities Act and the Exchange Act (including risks factors set forth therein) and the Purchaser represents that it has had an opportunity to ask questions and receive answers from the Company to evaluate the financial risk inherent in making an investment in the Securities. To the Purchaser's knowledge, the Purchaser has not been offered the opportunity to purchase the Securities by means of any general solicitation or general advertising.

4.8.     Risk of Investment . The Purchaser realizes that the purchase of the Securities will be a highly speculative investment and the Purchaser may suffer a complete loss of its investment. The Purchaser understands all of the risks related to the purchase of the Securities. By virtue of the Purchaser's experience in evaluating and investing in private placement transactions of securities in companies similar to the Company, the Purchaser is capable of evaluating the merits and risks of the Purchaser's investment in the Company and has the capacity to protect the Purchaser's own interests.

4.9.     Advisors . The Purchaser has reviewed with its own tax advisors the federal, state, and local tax consequences of this investment and the transactions contemplated by this Agreement. The Purchaser acknowledges that it has had the opportunity to review the Transaction Agreements and the transactions contemplated thereby with the Purchaser's own legal counsel.

4.10.     Finder . The Purchaser is not obligated and will not be obligated to pay any broker commission, finders' fee, success fee, or commission in connection with the transactions contemplated by this Agreement.

4.11.     Restricted Securities . The Purchaser understands that the Securities must be held indefinitely unless subsequently registered under the Securities Act or unless an exemption from registration is otherwise available. Moreover, the Purchaser understands that

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except as set forth in the Rights Agreement, the Company is under no obligation to register the Securities. The Purchaser is aware of Rule 144 promulgated under the Securities Act that permits limited resales of securities purchased in a private placement subject to the satisfaction of certain conditions.

4.12.     Legend . It is understood by the Purchaser that the Security and any other document representing or evidencing the Securities shall be endorsed with a legend substantially in the following form:

THE SECURITIES REPRESENTED BY THIS NOTE AND THE SECURITIES ISSUABLE UPON ITS CONVERSION HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “ ACT ”), OR SECURITIES LAWS OF ANY STATE AND MAY NOT BE OFFERED, SOLD, ASSIGNED, PLEDGED TRANSFERRED OR OTHERWISE DISPOSED OF IN THE ABSENCE OF AN EFFECTIVE REGISTRATION STATEMENT UNDER THE ACT AND APPLICABLE STATE SECURITIES LAWS OR PURSUANT TO AN AVAILABLE EXEMPTION FROM REGISTRATION UNDER THE ACT OR SUCH LAWS AND, IF REASONABLY REQUESTED BY THE COMPANY, UPON DELIVERY OF AN OPINION OF COUNSEL REASONABLY SATISFACTORY TO THE COMPANY THAT THE PROPOSED TRANSFER IS EXEMPT FROM THE ACT OR SUCH LAWS. THIS NOTE IS ALSO SUBJECT TO THE TRANSFER RESTRICTIONS CONTAINED IN THE SECURITIES PURCHASE AGREEMENT, DATED AS OF JULY 30, 2012, AMONG THE COMPANY AND TOTAL GAS & POWER USA, SAS.
Subject to Section 8.3 , the Company need not register a transfer of Securities unless the conditions specified in the foregoing legend are satisfied. Subject to Section 8.3 , the Company may also instruct its transfer agent not to register the transfer of any of the Securities unless the conditions specified in the foregoing legend are satisfied.
4.13.     Investor Qualification . The Purchaser is an “accredited investor” as defined in Rule 501(a) of Regulation D under the Securities Act.

ARTICLE 5
CONDITIONS TO COMPANY'S OBLIGATIONS AT EACH CLOSING

5.1.     Conditions to Company's Obligations at the Initial Closing . The Company's obligation to complete the sale and issuance of the Securities and deliver the Securities to the Purchaser at the Initial Closing shall be subject to the following conditions to the extent not waived by the Company:

(a) Receipt of Payment . The Company shall have received payment, by wire transfer of immediately available funds, in the full amount of the portion of the Initial Closing

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Purchase Price to be paid in the first installment under the Initial Closing pursuant hereto for the Security to be purchased by and sold to the Purchaser in the first installment under the Initial Closing, less the amount to be retained by the Purchaser pursuant to Section 8.4.

(b) Representations and Warranties . The representations and warranties made by the Purchaser in Section 4 hereof shall be true and correct in all material respects as of, and as if made on, the date of this Agreement and as of the Initial Closing.

(c) Receipt of Rights Agreement . The Purchaser shall have executed and delivered to the Company the Rights Agreement, duly executed by the Purchaser.

(d) Receipt of Second Amendment . The Purchaser shall have executed and delivered to the Company the Second Amendment, duly executed by the Purchaser.

(e) Receipt of Master Framework Agreement . The Purchaser shall have executed and delivered to the Company the Master Framework Agreement, duly executed by the Purchaser.

5.2.     Conditions to Company's Obligations at Each Subsequent Closing . The Company's obligation to complete the sale and issuance of the Securities and deliver the Securities to the Purchaser at each Subsequent Closing shall be subject to the following conditions to the extent not waived by the Company:
 
(a) Receipt of Payment . The Company shall have received payment, by wire transfer of immediately available funds, in the full amount of the portion of the applicable Purchase Price to be paid in the first installment under the applicable Subsequent Closing pursuant hereto for the Security to be purchased by and sold to the Purchaser in the first installment under such applicable Subsequent Closing.

(b) Representations and Warranties . The representations and warranties made by the Purchaser in Section 4 hereof shall be true and correct in all material respects as of, and as if made as of, the applicable Subsequent Closing.

(c) Absence of No-Go Decision . A “No-Go Decision” under the Master Framework Agreement shall not have been made in accordance with the Master Framework Agreement.

ARTICLE 6
CONDITIONS TO PURCHASER'S OBLIGATIONS AT EACH CLOSING

6.1.     Conditions to the Purchaser's Obligations at the Initial Closing. The Purchaser's obligation to accept delivery of the Securities and to pay for the Securities at the Initial Closing shall be subject to the following conditions to the extent not waived by the Purchaser:

(a) Representations and Warranties . The representations and warranties made by the Company in Section 3 hereof shall be true and correct in all respects as of, and as if made on, the date of this Agreement and as of the Initial Closing.


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(b) Receipt of Securities . The Company shall have executed and delivered to the Purchaser the Securities to be purchased by and sold to the Purchaser in the first installment under the Initial Closing as described herein, duly executed by the Company.

(c) Receipt of Rights Agreement . The Company shall have executed and delivered to the Purchaser the Rights Agreement, duly executed by the Company.

(d) Receipt of Second Amendment . The Company shall have executed and delivered to the Purchaser the Second Amendment, duly executed by the Company.

(e) Receipt of Master Framework Agreement . The Company shall have executed and delivered to the Purchaser the Master Framework Agreement, duly executed by the Company.

(f) Legal Opinion . The Purchaser shall have received an opinion of Shearman & Sterling LLP, counsel to the Company, substantially in the form set forth in Exhibit C hereto.

(g) Certificate . The Purchaser shall have received a certificate signed by the Company's Chief Executive Officer and Chief Financial Officer to the effect that the representations and warranties of the Company in Section 3 hereof are true and correct in all respects as of, and as if made on, the date of this Agreement and as of the Initial Closing and that the Company has satisfied in all material respects all of the conditions set forth in this Agreement with respect to the Initial Closing.

(h) Good Standing . The Company is validly existing as a corporation in good standing under the laws of Delaware as evidenced by a certificate of the Secretary of State of the State of Delaware, a copy of which was provided to the Purchaser.

(i) Secretary's Certificate . A certificate, executed by the Secretary of the Company and dated as of the Initial Closing Date, as to (A) the resolutions approving the issuance of the Securities (including the issuance of the Underlying Securities upon conversion thereof) as adopted by an Independent Committee of the Board of Directors and/or the Company's Board of Directors in a form reasonably acceptable to the Purchaser, (B) the certificate of incorporation, and (C) the bylaws, each as in effect as of the Initial Closing Date.

(j) Board Approval . The terms and conditions of the issuance of the Securities (including the issuance of the Underlying Securities upon conversion thereof) and the Transaction Agreements shall have been approved by an Independent Committee of the Board of Directors and/or a majority of the disinterested directors of the Board of Directors, as applicable.

(k) Approvals . The Company shall have obtained all governmental, regulatory or third party consents and approvals, if any, and given all notices, if any, necessary for the sale of the Securities, including, without limitation, from the NASDAQ Global Select Market.


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6.2.     Conditions to The Purchaser's Obligations at each Subsequent Closing . The Purchaser's obligation to accept delivery of the Securities and to pay for the Securities at any Subsequent Closing shall be subject to the following conditions to the extent not waived by the Purchaser:

(a) Representations and Warranties . The representations and warranties made by the Company in Section 3 hereof shall be true and correct in all material respects as of, and as if made as of, each applicable Subsequent Closing.

(b) Receipt of Securities . The Company shall have executed and delivered to the Purchaser the Securities to be purchased by and sold to the Purchaser in the first installment under the applicable Subsequent Closing as described herein, duly executed by the Company.

(c) Legal Opinion . The Purchaser shall have received an opinion of Shearman & Sterling LLP, counsel to the Company, substantially in the form set forth in Exhibit C hereto.

(d) Certificate . The Purchaser shall have received a certificate signed by the Company's Chief Executive Officer and Chief Financial Officer to the effect that the representations and warranties of the Company referred to in Section 6.2(a) hereof are true and correct in all material respects as of, and as if made as of each applicable Subsequent Closing and that the Company has satisfied in all material respects all of the conditions set forth in this Agreement with respect to each applicable Subsequent Closing.

(e) Good Standing . The Company is validly existing as a corporation in good standing under the laws of Delaware as evidenced by a certificate of the Secretary of State of the State of Delaware, a copy of which was provided to the Purchaser.

(f) Secretary's Certificate . A certificate, executed by the Secretary of the Company and dated as of any Subsequent Closing Date, as to (A) the certificate of incorporation, and (B) the bylaws, each as in effect as of any Subsequent Closing Date.

(g) Approvals . The Company shall have obtained all governmental, regulatory or third party consents and approvals, if any, and given all notices, if any, necessary for the sale of the Securities, including, without limitation, from the NASDAQ Global Select Market.

(h) Absence of No-Go Decision . A “No-Go Decision” under the Master Framework Agreement shall not have been made in accordance with the Master Framework Agreement.

In the event the Initial Closing shall have occurred, the Company shall be irrevocably committed to issue and sell to the Purchaser, and the Purchaser shall be irrevocably committed to purchase from the Company, the Securities to be issued, sold and purchased in the second installment of the Initial Closing with no additional conditions except that (i) the following representations and warranties made by the Company shall be true and correct in all material respects as of, and if as

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made as of, the second installment of the Initial Closing: 3.1 (organization and standing); 3.3 (power); 3.4 (authorization); 3.5 (consents and approvals); 3.6 (non-contravention); 3.7 (the securities); 3.8 (the underlying securities); 3.9 (no registration); 3.14(b) (no violations under the Securities); 3.16 (listing compliance); 3.23 (solvency) (assuming for this purpose that the payment to be made in the second installment of the Initial Closing was instead made concurrent with the Initial Closing); 3.28 (investment company); 3.37 (integration; other issuances of securities); 3.38 (no general solicitation) (the “ Installment Representations and Warranties ”); (ii) the Purchaser shall have received a certificate signed by the Company's Chief Executive Officer and Chief Financial Officer to the effect that the Installment Representations and Warranties are true and correct in all material respects as of, and as if made as of, the second installment of the Initial Closing and that the Company has satisfied in all material respects all of the conditions set forth in this Agreement with respect to the second installment of the Initial Closing; and (iii) the Purchaser shall have received an opinion of Shearman & Sterling LLP, counsel to the Company, substantially in the form set forth in Exhibit C hereto. In the event the Third Closing shall have occurred, the Company shall be irrevocably committed to issue and sell to the Purchaser, and the Purchaser shall be irrevocably committed to purchase from the Company, the Securities to be issued, sold and purchased in the second installment of the Third Closing with no additional conditions except that (i) the Installment Representations and Warranties by the Company shall be true and correct in all material respects as of, and if as made as of, the second installment of the Third Closing (assuming for this purpose that, in the case of the representations and warranties made by the Company in Section 3.23 (solvency), the payment to be made in the second installment of the Third Closing was instead made concurrent with the Third Closing); (ii) the Purchaser shall have received a certificate signed by the Company's Chief Executive Officer and Chief Financial Officer to the effect that the Installment Representations and Warranties are true and correct in all material respects as of, and as if made as of, the second installment of the Third Closing and that the Company has satisfied in all material respects all of the conditions set forth in this Agreement with respect to the second installment of the Third Closing; and (iii) the Purchaser shall have received an opinion of Shearman & Sterling LLP, counsel to the Company, substantially in the form set forth in Exhibit C hereto.
ARTICLE 7
COVENANTS OF THE COMPANY

7.1.     Payment of Principal and Interest . The Company covenants and agrees that it will duly and punctually pay the principal of and interest (including any additional interest upon an Event of Default or a Make-Whole Interest (as defined in the Securities) on the Securities in accordance with the terms of such Securities.

7.2.     Stay, Extension and Usury Laws . The Company covenants (to the extent that it may lawfully do so) that it will not at any time insist upon, plead, or in any manner whatsoever claim or take the benefit or advantage of, any stay, extension or usury law wherever enacted, now or at any time hereafter in force, which may affect the covenants or the performance of the Securities; and the Company (to the extent it may lawfully do so) hereby expressly waives all benefit or advantage of any such law.

7.3.     Corporate Existence . Subject to Section 7 of the Securities, the Company will do or cause to be done all things necessary to preserve and keep in full force and effect its

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corporate existence in accordance with its organizational documents and the rights (charter and statutory), licenses and franchises of the Company; provided , however , that the Company shall not be required to preserve any such right, license or franchise if the Board of Directors of the Company shall determine that the preservation thereof is no longer desirable in the conduct of the business of the Company and that the loss thereof is not adverse in any material respect to the Purchaser.

7.4.     Taxes . The Company shall pay prior to delinquency all taxes, assessments and governmental levies, except as contested in good faith and by appropriate proceedings.

ARTICLE 8
OTHER AGREEMENTS OF THE PARTIES

8.1.     Securities Laws Disclosure; Publicity . The initial press release regarding the transactions contemplated by the Transaction Agreements shall be a joint press release by the Company and the Purchaser and the text of such press release shall be agreed upon by the Company and the Purchaser. On or before 5:30 p.m., New York City time, on the fourth Business Day immediately following the execution of this Agreement, the Company will file a Current Report on Form 8-K with the SEC describing the terms of the Transaction Agreements. The Company and the Purchaser will maintain the confidentiality of all disclosures made to it in connection with this transaction (including, until such time as the transactions contemplated by the Transaction Agreements are required to be publicly disclosed by the Company as described in this Section 8.1 , the existence and terms of this transaction).

8.2.     Form D . The Company agrees to timely file a Form D with respect to the Securities sold at each Closing as required under Regulation D and to provide a copy thereof to the Purchaser ( provided that the posting of the Form D on the SEC's EDGAR system shall be deemed delivery of the Form D for purposes of this Agreement).

8.3.     Transfer Restrictions .

8.3.1    General. The Purchaser shall not, and shall not permit any of its Affiliates to, directly or indirectly, make, effect or otherwise consummate any Transfer of any Securities except in accordance with the terms and conditions of this Section 8.3 . As used herein, “ Transfer ” means, directly or indirectly, to offer, sell (including any short sale), transfer, assign, pledge, encumber, hypothecate or similarly dispose of (by merger, testamentary disposition, operation of law or otherwise), either voluntarily or involuntarily, or enter into any contract, option or other arrangement or understanding with respect to the offer, sale (including any short sale), transfer, assignment, pledge, encumbrance, hypothecation or similar disposition of (by merger, testamentary disposition, operation of law or otherwise), any Securities “beneficially owned” (as such term is defined in Rule 13d-3 and Rule 13d-5 under the Exchange Act) by a Person or any interest (including any right to all or any portion of the pecuniary interest in the security, including, without limitation, the right to receive interest, dividends and distributions, proceeds upon liquidation and receive the proceeds of disposition or conversion of the Securities. Whether or not treated as an offer or sale of the Securities under the Securities Act, “Transfer” shall also include any hedging or other transaction entered into after the date hereof, such as any purchase, sale (including any short sale) or grant of any right (including without limitation any

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put or call option) with respect to any of the Securities or with respect to any security that includes or derives any significant part of its value from such Securities. This Section 8.3 shall not be applicable to any of the Underlying Securities issued upon the conversion of any of the Securities in accordance with their terms following any such conversion.

8.3.2     Recognition of Transfer . No Transfer of any Securities that is in violation of this Section 8.3 shall be valid or effective, and the Company shall have no obligation to recognize such invalid Transfer. The Company shall not incur any liability as a result of refusing to make any payments of any kind in respect of the Securities to the transferee of any such invalid Transfer.

8.3.3     Permitted Transferees . Notwithstanding the restrictions in this Section 8.3 , but subject to Section 8.3.1 and Section 8.3.2 , the Purchaser shall be permitted to Transfer all or any portion of its Securities to an Affiliate (a “ Permitted Transferee ”); provided , however , that (a) such Affiliate shall execute a statement in writing and reasonably acceptable to the Company whereby such Affiliate expressly agrees to become a party to this Agreement and the other Transaction Agreements, and (b) if such Affiliate ceases at any time after any such Transfer to be an Affiliate of the Purchaser, all Securities previously Transferred to such Affiliate shall be required to be promptly Transferred back to the Purchaser. No Transfer of Securities to a Permitted Transferee shall release the Purchaser from liability for the obligations of the Purchaser and its Permitted Transferee pursuant to this Agreement and the other Transaction Agreements.

8.4.     Use of Proceeds . The Company agrees to use $23,300,000 of the proceeds of the offering to be received by the Company in the first installment of the Initial Closing to immediately repay the Purchaser (which amount may be retained by the Purchaser and applied to such repayment) for research and development funding provided by the Purchaser pursuant to the Renewable Diesel Development Project Plan under the Current Collaboration Agreement. The Company agrees to use the remainder of the proceeds of the offering to fund activities under the Biofene Development Project Plan under the Collaboration Agreement as amended by the Second Amendment. The Company shall not use the proceeds of the offering in a manner that would require the Company to register as an investment company under the Investment Company Act of 1940, as amended.

8.5.     Subsequent Securities Sales . The Company shall not, and shall use its commercially reasonable efforts to ensure that no Affiliate of the Company shall, sell, offer for sale or solicit offers to buy or otherwise negotiate in respect of any security (as defined in Section 2 of the Securities Act) that will be integrated with the offer or sale of the Securities in a manner that would require the registration under the Securities Act of the sale of the Securities to the Purchaser, or that will be integrated with the offer or sale of the Securities for purposes of the rules and regulations of any trading market such that it would require stockholder approval prior to the closing of such other transaction unless stockholder approval is obtained before the closing of such subsequent transaction.


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8.6.     Listing; SEC Compliance .

(a) Listing . The Company shall promptly take any action required to maintain on each Security the listing of all of the Underlying Securities upon each national securities exchange and automated quotation system, if any, upon which shares of Common Stock are then listed (subject to official notice of issuance) and shall maintain, so long as any other shares of Common Stock shall be so listed, such listing of the Underlying Securities from time to time issuable under the terms of the Securities. The Company shall not take any action which would be reasonably expected to result in the delisting or suspension of the Common Stock on The NASDAQ Stock Market.

(b) SEC Filings . The Company shall take all actions within its control to comply with the reporting requirements of the Exchange Act and each applicable national securities exchange and automated quotation system on which the Common Stock is listed. The Purchaser's sole remedy for breach of this Section 8.6(b) will be as set forth in Section 5 of the Securities.

(c) Current Information . The Company shall make and keep public information available, as those terms are understood and defined in SEC Rule 144 for so long as required in order to permit the resale of the Underlying Securities pursuant to SEC Rule 144.

8.7.     Register . The Company shall keep a “register” which shall provide for the recordation of the name and address of, and the amount of each Security and the outstanding principal and interest on each Security owing to, the Purchaser. The entries in the register shall be conclusive evidence of the amounts due and owing to the Purchaser in the absence of manifest error. The obligations of the Company to the Purchaser under the Securities (the “ Obligations ”) are registered obligations and the right, title and interest of the Purchaser and its assignees in and to such Obligations shall be transferable only upon notation of such transfer in the register. This Section 8.7 shall be construed so that the Obligations are at all times maintained in “registered form” within the meaning of Sections 163(f), 871(h)(2) and 881(c)(2) of the Code and any related regulations (and any other relevant or successor provisions of the Code or such regulations). The register shall be available for inspection by the Purchaser from time to time upon reasonable prior notice.

8.8.     Federal Income Tax Reporting . Notwithstanding anything to the contrary contained herein, each party hereto hereby acknowledges and agrees that for United States federal, state and local income tax purposes, the aggregate “issue price” of the Securities under Section 1273(b) of the Code shall equal $53,300,000, with respect to the Securities to be purchased and sold at the Initial Closing, $30,000,000, with respect to any Securities to be purchased and sold at any Second Closing, and $21,700,000, with respect to the Securities to be purchased and sold at any Third Closing. Each party hereto agrees to use the foregoing issue price for all income tax, financial accounting and regulatory purposes with respect to this transaction. Each party hereto further acknowledges and agrees that the Obligations shall be treated as debt for all tax and accounting purposes and no party shall take any position inconsistent therewith.

27



8.9.     Remedies for Purchaser Funding Default . In the event that the Purchaser fails to make full payment for the Security to be purchased by and sold to the Purchaser in any applicable installment under any Subsequent Closing in accordance with the terms hereof by the applicable date such installment was due, and such failure continues for 5 days after the applicable date such installment was due, the unfunded amount shall bear interest at a rate per annum equal to 2.50%. In the event such failure continues for 30 days after the applicable date such installment was due, the unfunded amount shall then bear interest at a rate per annum equal to 15%. All computations of interest under this Section 8.9 shall be made on the basis of a 360-day year and actual days elapsed (which results in more interest being paid than if computed on the basis of a 365-day year). Such interest shall be paid monthly on each 1 month anniversary date of the applicable date such installment was due, and the Company shall be entitled to offset any such interest that is not paid when due against the principal amount of the Securities.

ARTICLE 9
MISCELLANEOUS

9.1.     Survival . The representations, warranties and covenants contained herein shall survive the execution and delivery of this Agreement and the sale of the Securities.

9.2.     Indemnification .
 
(a) Indemnification of Purchaser . The Company agrees to indemnify and hold harmless the Purchaser and its Affiliates and their respective directors, officers, trustees, members, managers, employees and agents, and their respective successors and assigns, from and against any and all losses, claims, damages, liabilities and expenses (including without limitation reasonable attorney fees and disbursements and other expenses reasonably incurred in connection with investigating, preparing or defending any action, claim or proceeding, pending or threatened and the costs of enforcement thereof) (collectively, “ Losses ”) to which such Person may become subject as a result of any breach of representation, warranty, covenant or agreement made by or to be performed on the part of the Company under this Agreement, and will reimburse any such Person for all such amounts as they are incurred by such Person.

(b) Conduct of Indemnification Proceedings . Any Person entitled to indemnification hereunder shall (i) give prompt notice to the indemnifying party of any claim with respect to which it seeks indemnification and (ii) subject to the Company acknowledging in writing that such claim is an indemnifiable claim under this Agreement, permit such indemnifying party to assume the defense of such claim with counsel reasonably satisfactory to the indemnified party; provided that any Person entitled to indemnification hereunder shall have the right to employ separate counsel and to participate in the defense of such claim, but the fees and expenses of such counsel shall be at the expense of such Person unless (a) the indemnifying party has agreed to pay such fees or expenses, or (b) the indemnifying party shall have failed to assume the defense of such claim and employ counsel reasonably satisfactory to such Person or (c) in the reasonable judgment of any such Person, based upon written advice of its counsel, a conflict of interest exists between such Person and the indemnifying party with respect to such claims (in which case, if the Person notifies the indemnifying party in writing that such Person elects to employ separate counsel at the expense of the indemnifying party, the indemnifying party shall not have the right to assume the defense of such claim on behalf of such Person); and

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provided , further , that the failure of any indemnified party to give notice as provided herein shall not relieve the indemnifying party of its obligations hereunder, except to the extent that such failure to give notice shall materially adversely affect the indemnifying party in the defense of any such claim or litigation. It is understood that the indemnifying party shall not, in connection with any proceeding in the same jurisdiction, be liable for fees or expenses of more than one separate firm of attorneys at any time for all such indemnified parties. No indemnifying party will, except with the consent of the indemnified party, which consent shall not be unreasonably withheld, conditioned or delayed, consent to entry of any judgment or enter into any settlement that does not include as an unconditional term thereof the giving by the claimant or plaintiff to such indemnified party of a release from all liability in respect of such claim or litigation. No indemnified party will, except with the consent of the indemnifying party, consent to entry of any judgment or enter into any settlement.

9.3.     Assignment; Successors and Assigns . Except as contemplated by Section 8.3.3, this Agreement may not be assigned by either party without the prior written consent of the other party. This Agreement and all provisions thereof shall be binding upon, inure to the benefit of, and are enforceable by the parties hereto and their respective successors and permitted assigns.

9.4.     Notices . All notices, requests, and other communications hereunder shall be in writing and will be deemed to have been duly given and received (a) when personally delivered, (b) when sent by facsimile upon confirmation of receipt, (c) one business day after the day on which the same has been delivered prepaid to a nationally recognized courier service, or (d) five business days after the deposit in the United States mail, registered or certified, return receipt requested, postage prepaid, in each case to the applicable address set forth below:

If to the Company, to:
Amyris, Inc.
5885 Hollis Street, Suite 100
Emeryville, CA 94608
United States of America
Attn:     General Counsel
Fax. No.: +1 (510) 842-1460

with a copy (which shall not constitute notice) to:

Shearman & Sterling LLP
Four Embarcadero Center, Suite 3800
San Francisco, CA  94111-5994
United States of America
Attn:    Michael S. Dorf
Fax. No.: +1 (415) 616-1446

If to the Purchaser, to:

Total Gas & Power USA, SAS
2, place Jean Millier

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La Défense 6
92400 Courbevoie
France
Attn:     Bernard Clément
Fax. No.: +331 4744 8178

with a copy (which shall not constitute notice) to:

Wilson Sonsini Goodrich & Rosati
Professional Corporation
650 Page Mill Road
Palo Alto, CA 94304
United States of America
Attn:     David J. Segre
Michael Occhiolini
Richard Cameron Blake
Fax No.: +1 (650) 493-6811

Any party hereto from time to time may change its address, facsimile number, or other information for the purpose of notices to that party by giving notice specifying such change to the other parties hereto. The Purchaser and the Company may each agree in writing to accept notices and other communications to it hereunder by electronic communications pursuant to procedures reasonably approved by it; provided that approval of such procedures may be limited to particular notices or communications.

9.5.     Governing Law; Jurisdiction .

(a) Governing Law . This Agreement, and the provisions, rights, obligations, and conditions set forth herein, and the legal relations between the parties hereto, including all disputes and claims, whether arising in contract, tort, or under statute, shall be governed by and construed in accordance with the laws of the State of New York without giving effect to its conflict of law provisions.

(b) Jurisdiction . Any and all disputes arising out of, or in connection with, the interpretation, performance, or nonperformance of this Agreement or any and all disputes arising out of, or in connection with, transactions in any way related to this Agreement and/or the relationship between the parties shall be litigated solely and exclusively before the United States District Court for the Southern District of New York. The parties consent to the in personam jurisdiction of said court for the purposes of any such litigation, and waive, fully and completely, any right to dismiss and/or transfer any action pursuant to 28 U.S.C. § 1404 or 1406 (or any successor statute). In the event the United States District Court for the Southern District of New York does not have subject matter jurisdiction of said matter, then such matter shall be litigated solely and exclusively before the appropriate state court of competent jurisdiction located in the state of New York.

9.6.     Severability . In the event that any provision of this Agreement or the application of any provision hereof is declared to be illegal, invalid, or otherwise unenforceable

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by a court of competent jurisdiction, the remainder of this Agreement shall not be affected except to the extent necessary to delete such illegal, invalid, or unenforceable provision unless that provision held invalid shall substantially impair the benefits of the remaining portions of this Agreement.

9.7.     Headings . The headings in this Agreement are for convenience of reference only and shall not constitute a part of this Agreement, nor shall they affect its meaning, construction, or effect.

9.8.     Entire Agreement . This Agreement embodies the entire understanding and agreement between the parties hereto with respect to the subject matter hereof and supersedes all prior agreements and understandings relating to the subject matter hereof.

9.9.     Finder's Fee . The Company agrees that it shall be responsible for the payment of any placement agent's fees, financial advisory fees, or brokers' commissions (other than for Persons engaged by the Purchaser) relating to or arising out of the transactions contemplated hereby. The Company shall pay, and hold the Purchaser harmless against, any liability, loss or expense (including, without limitation, attorney's fees and out-of-pocket expenses) arising in connection with any claim for any such fees or commissions.

9.10.     Expenses . Each party will bear its own costs and expenses in connection with this Agreement.

9.11.     Further Assurances . The parties agree to execute and deliver all such further documents, agreements and instruments and take such other and further action as may be necessary or appropriate to carry out the purposes and intent of this Agreement.

9.12.     Counterparts . This Agreement may be executed in two or more counterparts, each of which shall constitute an original, but all of which, when taken together, shall constitute but one instrument, and shall become effective when one or more counterparts have been signed by each party hereto and delivered to the other party. Facsimile signatures shall be deemed originals for all purposes hereunder.

[Signature page follows]


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This Securities Purchase Agreement is hereby confirmed and accepted by the Company as of July 30, 2012.
AMYRIS, INC.
By: /s/ John Melo    
Name: John Melo
Title: President and Chief Executive Officer

TOTAL GAS & POWER USA, SAS
By: /s/ Bernard Clément    
Name: Bernard Clément
Title: Authorized Signatory










[Signature Page to Securities Purchase Agreement]


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Exhibit A
FORM OF SECURITY
(see Exhibit 4.02 as filed to this Form 10-Q)




Exhibit B
RIGHTS AGREEMENT
(see Exhibit 4.03 as filed to this Form 10-Q)





Exhibit C
Opinion of Company Counsel





July 30, 2012
Total Gas & Power USA, SAS
2, place Jean Millier
La Défense 6
92400 Courbevoie
France
Amyris, Inc.
1.5% Senior Unsecured Convertible Notes due 2017
Ladies and Gentlemen:
We have acted as counsel to Amyris, Inc., a Delaware corporation (the “ Company ”), in connection with the purchase by you, subject to the terms and conditions set forth in the Securities Purchase Agreement, dated as of July 30, 2012 (the “ Purchase Agreement ”), between you and the Company, of a 1.5% Senior Unsecured Convertible Note due 2017 (the “ Note ”) in an aggregate principal amount of $38,300,000 at the Initial Closing (as defined in the Purchase Agreement) under the Purchase Agreement.
This opinion is being delivered pursuant to Section 6.1(f) of the Purchase Agreement. Capitalized terms used herein without definition shall have the meanings assigned to them in the Purchase Agreement.
In that connection, we have reviewed originals or copies of the following documents:
(a) The Purchase Agreement.

(b) The Note.

(c) The Rights Agreement.

The documents described in the foregoing clauses (a), and (b) and (c) are collectively referred to herein as the “ Opinion Documents ”.
We have also reviewed the following:
(a) The Certificate of Incorporation and By-laws of the Company, each as amended and restated through the date hereof;




(b) Originals or copies of the agreements set forth on Schedule A; and

(c) Originals or copies of such other corporate records of the Company, certificates of public officials and of officers of the Company and agreements and other documents as we have deemed necessary as a basis for the opinions expressed below.

In our review of the Opinion Documents and other documents, we have assumed:

(a) The genuineness of all signatures.

(b) The authenticity of the originals of the documents submitted to us.

(c) The conformity to authentic originals of any documents submitted to us as copies.

(d) As to matters of fact, the truthfulness of the representations made in the Opinion Documents and in certificates of public officials and officers of the Company.

(e) That each of the Opinion Documents is the legal, valid and binding obligation of each party thereto, other than the Company, enforceable against each such party in accordance with its terms.

(f) That:

(i) The Company was duly organized under the laws of the jurisdiction of its organization.

(ii) The execution, delivery and performance by the Company of the Opinion Documents do not:

(A) except with respect to Generally Applicable Law, violate any law, rule or regulation applicable to it; or

(B) result in any conflict with or breach of any document or contract binding on the Company or any of its subsidiaries (other than any of the agreements set forth on Schedule A).

(iii) Except with respect to Generally Applicable Law, no authorization, approval or other action by, and no notice to or filing with, any governmental authority or regulatory body or (to the extent the same is required under any agreement or document binding on the Company or any of its subsidiaries of which you have knowledge, have received notice or have reason to know) any other third party is required for the due execution, delivery or




performance by the Company of any Opinion Document or, if any such authorization, approval, consent, action, notice or filing is required, it has been duly obtained, taken, given or made and is in full force and effect.

We have not independently established the validity of the foregoing assumptions.
Generally Applicable Law ” means the federal law of the United States of America, and the law of the State of New York (including the rules or regulations promulgated thereunder or pursuant thereto), that a New York lawyer exercising customary professional diligence would reasonably be expected to recognize as being applicable to the Company, the Opinion Documents or the transactions governed by the Opinion Documents, and for purposes of assumption paragraph (f) above and our opinions in paragraphs 1, 2, 3, 4, 5, 6(a) and 7 below, the General Corporation Law of the State of Delaware. Without limiting the generality of the foregoing definition of Generally Applicable Law, the term “Generally Applicable Law” does not include any law, rule or regulation that is applicable to the Company, the Opinion Documents or such transactions solely because such law, rule or regulation is part of a regulatory regime applicable to any party to any of the Opinion Documents or any of its affiliates due to the specific assets or business of such party or such affiliate. We express no opinion with respect to any laws, rules or regulations (whether at a federal, state or local level) pertaining to the manufacturing processes, intermediate products and research or commercial products of the Company and its subsidiaries, including, without limitation, products or compounds currently under research and/or development by the Company and its subsidiaries subject to the jurisdiction of the United States Environmental Protection Agency (“ EPA ”) under the Toxic Substances Control Act and regulations thereunder (“ TSCA ”) or the Food and Drug Administration (“ FDA ”) under the Federal Food, Drug and Cosmetic Act and the regulations thereunder (“ FDCA ”). Accordingly, matters involving such laws, rules or regulations are excluded from this opinion.
In rendering the opinions set forth in paragraph 1 below, we have relied exclusively on a certificate of status regarding the Company issued by the Secretary of State of the State of Delaware dated July 27, 2012, a letter regarding the Company from the California Franchise Tax Board dated July 26, 2012, and a certificate of good standing regarding the Company issued by the Secretary of State of the State of California dated July 27, 2012.
Based upon the foregoing and upon such other investigation as we have deemed necessary and subject to the qualifications set forth below, we are of the opinion that:
1. The Company is a corporation validly existing and in good standing under the laws of the State of Delaware. The Company is qualified to do business and in good standing as a foreign corporation in the State of California.

2. The Company (a) has the corporate power to execute, deliver and perform each Opinion Document, and (b) has taken all corporate action necessary to authorize the execution, delivery and performance of each Opinion Document.




3. The shares of Common Stock issuable upon conversion of the Note have been duly authorized and reserved for issuance upon such conversion, and such shares, when issued and delivered by the Company as provided in the Note, will be validly issued, fully paid and non-assessable, and the issuance of such shares will not be subject to preemptive rights pursuant to the General Corporation Law of the State of Delaware, the Certificate of Incorporation or By-laws of the Company, or any of the agreements set forth on Schedule A.

4. The Purchase Agreement and the Rights Agreement have been duly authorized, executed and delivered by the Company and constitute the legal, valid and binding obligations of the Company, enforceable against the Company in accordance with their respective terms.

5. The Note has been duly authorized and executed by the Company and, when delivered and paid for as provided in the Purchase Agreement, the Note will be the legal, valid and binding obligation of the Company, enforceable against the Company in accordance with its terms.

6. The execution and delivery by the Company of each Opinion Document do not, and the performance by the Company of its obligations thereunder and the consummation of the transactions contemplated thereby will not, (a) result in a violation of the Certificate of Incorporation or By-laws of the Company, (b) result in a violation of Generally Applicable Law, or (c) result in a breach of, a default under or the acceleration of (or entitle any party to accelerate) the maturity of any obligation of the Company under, or result in or require the creation of any lien upon or security interest in any property of the Company pursuant to, the terms of any of the agreements set forth on Schedule A.

7. No authorization, approval or other action by, and no notice to or filing with, any United States federal or New York state or Delaware (under the General Corporation Law of the State of Delaware) governmental authority or regulatory body is required for the due execution, delivery or performance by the Company of any Opinion Document, except (i) as may be required under the securities or blue sky laws of any State in the United States in connection with the offer and sale of the Note, (ii) as may be required under the Securities Act of 1933, as amended, in connection with the registration statement contemplated by the Rights Agreement, and (iii) for the authorizations, approvals, actions, notices and filings specified in the Purchase Agreement.

8. The Company is not, and after the issuance of the Notes and the use of the proceeds therefrom as contemplated in the Purchase Agreement will not be, required to register as an investment company under the Investment Company Act of 1940, as amended.





9. Based upon the representations, warranties and agreements of the Company and you in the Purchase Agreement, it is not necessary in connection with the offer and sale of the Note to you under the Purchase Agreement to register the Note under the Securities Act of 1933, as amended, it being understood that no opinion is expressed as to any subsequent resale of the Note.

Our opinions expressed above are subject to the following qualifications:
(a) Our opinions in paragraphs 4 and 5 above are subject to (i) the effect of any applicable bankruptcy, insolvency, reorganization, moratorium or similar laws affecting creditors' rights generally (including without limitation all laws relating to fraudulent transfers) and (ii) possible judicial action giving effect to governmental actions or foreign laws affecting creditors' rights.
(b) Our opinions in paragraphs 4 and 5 above are also subject to the effect of general principles of equity, including without limitation concepts of materiality, reasonableness, good faith and fair dealing (regardless of whether considered in a proceeding in equity or at law). We express no opinion as to the validity, legally binding effect or enforceability of any provision in the Opinion Documents that requires or relates to adjustments to the conversion rate in an amount that a court would determine in the circumstances under applicable law to be commercially unreasonable or a penalty or forfeiture.

(c) Our opinions are limited to (i) Generally Applicable Law, (ii) in the case of our opinion in paragraph 8 above, the Investment Company Act of 1940, as amended, and (iii) in the case of our opinion in paragraph 9 above, the Securities Act of 1933, as amended, and we do not express any opinion herein concerning (x) antitrust laws, (y) any anti-fraud provisions of federal or state securities laws or “blue sky” laws or (z) any other law.

(d)    The enforcement of any rights to indemnity and contribution under the Purchase Agreement and the Rights Agreement may be limited by federal and state securities laws and principles of public policy.

In addition to the foregoing opinions, we supplementally confirm to you that, as of immediately prior to the Closing, to our knowledge, without investigation, there is no action, suit, investigation, litigation or proceeding against the Company pending or threatened in writing before any United States federal, California state, New York state or Delaware state court or governmental authority that challenges the legality, validity or enforceability of any Opinion Document.
This opinion letter is rendered to you in connection with the transactions contemplated by the Opinion Documents. This opinion letter may not be referred to or relied upon by you for any other purpose without our prior written consent




This opinion letter speaks only as of the date hereof. We expressly disclaim any responsibility to advise you of any development or circumstance of any kind, including any change of law or fact, that may occur after the date of this opinion letter that might affect the opinions expressed herein.

Very truly yours,
/s/ Shearman & Sterling LLP




SCHEDULE A

1.
Securities Purchase Agreement dated as of February 24, 2012, by and between the Company and the individuals or entities listed on Schedule I thereto, with respect to the sale of $25,000,000 in principal amount of the Company's Convertible Senior Notes due 2017.

2.
Asset Purchase Agreement, dated as of October 6, 2011, between Draths Corporation and the Company.

3.
Registration Rights Agreement, dated February 27, 2012, between the Company and the Company's security holders listed therein.

4.
Securities Purchase Agreement, dated May 18, 2012, among the Company and certain investors listed therein.





1.5% SENIOR UNSECURED CONVERTIBLE NOTE
R-1                                            July 30, 2012
U.S.$38,300,000
THE SECURITIES REPRESENTED BY THIS NOTE AND THE SECURITIES ISSUABLE UPON ITS CONVERSION HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “ACT”), OR SECURITIES LAWS OF ANY STATE AND MAY NOT BE OFFERED, SOLD, ASSIGNED, PLEDGED TRANSFERRED OR OTHERWISE DISPOSED OF IN THE ABSENCE OF AN EFFECTIVE REGISTRATION STATEMENT UNDER THE ACT AND APPLICABLE STATE SECURITIES LAWS OR PURSUANT TO AN AVAILABLE EXEMPTION FROM REGISTRATION UNDER THE ACT OR SUCH LAWS AND, IF REASONABLY REQUESTED BY THE COMPANY, UPON DELIVERY OF AN OPINION OF COUNSEL REASONABLY SATISFACTORY TO THE COMPANY THAT THE PROPOSED TRANSFER IS EXEMPT FROM THE ACT OR SUCH LAWS. THIS NOTE IS ALSO SUBJECT TO THE TRANSFER RESTRICTIONS CONTAINED IN THE SECURITIES PURCHASE AGREEMENT, DATED AS OF JULY 30, 2012, AMONG THE COMPANY AND TOTAL GAS & POWER USA, SAS.
FOR VALUE RECEIVED, the undersigned, Amyris, Inc., a Delaware corporation (the “ Company ”), promises to pay to Total Gas & Power USA, SAS, a société par actions simplifiée organized under the laws of the Republic of France, or its Permitted Transferees pursuant to Section 13 of this Note (the “ Investor ”), in lawful money of the United States and in immediately available funds (or in shares of Common Stock as provided herein), U.S. $38,300,000 (the “ Face Amount ”), all in accordance with the provisions of this Note. The “ Issue Date ” of this Note is July 30, 2012.
This Note was issued pursuant to the Securities Purchase Agreement, dated as of July 30, 2012 (as amended from time to time, the “ Agreement ”), among the Company and the Investor. Unless the context otherwise requires, as used herein, “ Note ” means any of the Convertible Notes issued to the Investor pursuant to the Agreement and any other similar convertible notes issued by the Company in exchange for, or to effect a transfer of, any Note and “ Notes ” means all such Notes in the aggregate.
1. Definitions. For purposes of this Note, the following definitions shall be applicable:

Affiliate ” of any specified person means any other person directly or indirectly controlling or controlled by or under direct or indirect common control with such specified person; for purposes of this definition, “control” (including, with correlative meanings, the terms “controlling,” “controlled by” and 'under common control with”), as used with respect to any person, shall mean the possession, directly or indirectly, of the power to direct or cause the direction of the management or policies of such person, whether through the ownership of voting securities, by agreement or otherwise.

1



Bankruptcy Law ” means Title 11, U.S. Code or any similar federal or state law for the relief of debtors.
Board of Directors ” means the board of directors of the Company.
Business Day ” means any day other than a Saturday, a Sunday or a day on which the Federal Reserve Bank of New York is authorized or required by law or executive order to close or be closed.
Capital Lease Obligation ” means, at the time any determination thereof is to be made, the amount of the liability in respect of a capital lease that would at such time be required to be capitalized on a balance sheet in accordance with GAAP.
Certificate of Incorporation ” means the Company's Restated Certificate of Incorporation, as amended and as in effect on the date hereof.
Change of Control ” shall mean the occurrence of any of the following: (i) the consolidation of the Company with, or the merger of the Company with or into, another “person” (as such term is used in Rule 13d-3 and Rule 13d-5 of the Exchange Act), or the sale, lease, transfer, conveyance or other disposition, in one or a series of related transactions, of all or substantially all of the assets of the Company and its Subsidiaries taken as a whole, or the consolidation of another “person” with, or the merger of another “person” into, the Company, other than in each case pursuant to a transaction in which the “persons” that “beneficially owned” (as such term is defined in Rule 13d-3 and Rule 13d-5 under the Exchange Act), directly or indirectly, the Voting Shares of the Company immediately prior to the transaction “beneficially own”, directly or indirectly, Voting Shares representing at least a majority of the total voting power of all outstanding classes of voting stock of the surviving or transferee person; (ii) the adoption by the Company of a plan relating to the liquidation or dissolution of the Company; (iii) the consummation of any transaction (including, without limitation, any merger or consolidation) the result of which is that any “person” becomes the “beneficial owner” directly or indirectly, of more than 50% of the Voting Shares of the Company (measured by voting power rather than number of shares); or (iv) the first day on which a majority of the members of the Board of Directors does not consist of Continuing Directors.
Closing Price ” of the shares of Common Stock on any day means the last reported sale price regular way on such day or, in the case no such sale takes place on such day, the average of the reported closing bid and asked prices regular way of the shares of Common Stock, in each case as quoted on The NASDAQ Stock Market or such other principal securities exchange or inter-dealer quotation system on which the shares of Common Stock are then traded.
Common Stock ” means the Company's common stock, $0.0001 par value per share (or such other security into which such Common Stock is exchanged for (or becomes) pursuant to the consummation of a Capital Reorganization (as defined in Section 3(g))).
Company License Agreement ” means that certain license to be entered into by the Company pursuant to Section 11 of the Second Amendment.

2



Continuing Director ” shall mean, as of any date of determination, any member of the Board of Directors who (i) was a member of the Board of Directors on July 31, 2012 or (ii) was nominated for election or elected to the Board of Directors with the approval of a majority of the Continuing Directors who were members of the Board of Directors at the time of such nomination or election and who voted with respect to such nomination or election; provided that a majority of the members of the Board of Directors voting with respect thereto shall at the time have been Continuing Directors.
Debt ” shall mean, with respect to any person, any indebtedness of such person, whether or not contingent, in respect of borrowed money or evidenced by bonds, notes, debentures or similar instruments or letters of credit (or reimbursement agreements in respect thereof) or banker's acceptances or representing Capital Lease Obligations or the balance deferred and unpaid of the purchase price of any property or representing any Hedging Obligations, except any such balance that constitutes an accrued expense or trade payable, if and to the extent any of the foregoing indebtedness (other than letters of credit and Hedging Obligations) would appear as a liability upon a balance sheet of such Person prepared in accordance with GAAP, as well as all Debt of others secured by a Lien on any asset of such Person (whether or not such Debt is assumed by such Person) and Lease Debt and, to the extent not otherwise included, the Guarantee by such Person of any Debt of any other Person. The indebtedness of the Company represented by this Note shall constitute Debt. The amount of any Debt outstanding as of any date shall be (i) the accreted value thereof, in the case of any Debt that does not require current payments of interest or (ii) the principal amount thereof, together with any interest thereon that is more than 30 days past due, in the case of any other Debt.
Default ” means any event that is or with the passage of time or the giving of notice or both would be an Event of Default.
“Disqualified Stock ” means any capital stock that, by its terms (or by the terms of any security into which it is convertible, or for which it is exchangeable, in each case, at the option of the holder of the capital stock), or upon the happening of any event, matures or is mandatorily redeemable, pursuant to a sinking fund obligation or otherwise, or redeemable at the option of the holder of the capital stock, in whole or in part, on or prior to the date that is 91 days after the date on which this Note matures. The amount of Disqualified Stock deemed to be outstanding at any time will be the maximum amount that the Company and its Subsidiaries may become obligated to pay upon the maturity of, or pursuant to any mandatory redemption provisions of, such Disqualified Stock, exclusive of accrued dividends.
Exchange Act ” means the Securities Exchange Act of 1934, as amended, and the rules and regulations thereunder.
Final Go Decision Date ” has the meaning ascribed thereto in the Master Framework Agreement.
GAAP ” means generally accepted accounting principles set forth in the opinions and pronouncements of the Accounting Principles Board of the American Institute of Certified Public Accountants and statements and pronouncements of the Financial Accounting Standards Board

3



or in such other statements by such other entity as have been approved by a significant segment of the accounting profession in the United States, which are in effect from time to time.
Guarantee ” means a guarantee (other than by endorsement of negotiable instruments for collection in the ordinary course of business), direct or indirect, in any manner (including, without limitation, by way of a pledge of assets, letters of credit and reimbursement agreements in respect thereof), of all or any part of any Debt.
Hedging Obligations ” means, with respect to any person, the obligations of such person under (i) currency exchange or interest rate swap agreements, interest rate cap agreements and interest rate collar agreements and (ii) other agreements or arrangements designed to protect such person against fluctuations in interest rates or currency exchange rates.
Intellectual Property ” has the meaning ascribed thereto in the Agreement.
Jet Go Decision ” has the meaning ascribed thereto in the Master Framework Agreement.
Joint Venture ” shall mean the joint venture to be established between the Company and the Investor pursuant to Article 3 of the Master Framework Agreement.
Larger Shareholder ” shall mean any “person” or “group” (as each such term is used in Rule 13d-3 and Rule 13d-5 of the Exchange Act) who shall “beneficially own” (as such term is defined in Rule 13d-3 and Rule 13d-5 under the Exchange Act), directly or indirectly, Voting Shares of the Company (measured by voting power rather than number of shares) representing a larger number of Voting Shares than the number of Voting Shares of the Company (measured by voting power rather than number of shares) “beneficially owned”, directly or indirectly, by the Investor and its Affiliates, in each case as reported on (or required to have been reported on to the extent any “executive officer” (as such term is defined in Rule 3b-7 under the Exchange Act) of the Company has actual knowledge of the number of such “person” or “group's” Voting Shares) the most recent Schedule 13D or Schedule 13G or an amendment to any such Schedule filed with the Securities and Exchange Commission by any such “person” or “group” or by the Investor or any of its Affiliates or as otherwise publicly announced by any such “person” or “group” or by the Investor or any of its Affiliates.
Lease Debt ” means, with respect to any Person, (i) the amount of any accrued and unpaid obligations of such Person arising under any lease or related document (including a purchase agreement, conditional sale or other title retention agreement) in connection with the lease of real property or improvement thereon (or any personal property included as part of any such lease) which provides that such Person is contractually obligated to purchase or cause a third party to purchase the leased property or pay an agreed upon residual value of the leased property to the lessor (whether or not such lease transaction is characterized as an operating lease or a capitalized lease in accordance with GAAP) and (ii) the guarantee, direct or indirect, in any manner (including, without limitation, letters of credit and reimbursement agreements in respect thereof), of any of the amounts set forth in (i) above.
License Terms ” has the meaning ascribed thereto in the Second Amendment.

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Lien ” means, with respect to any asset, any mortgage, lien, pledge, charge, security interest or encumbrance of any kind in respect of such asset, whether or not filed, recorded or otherwise perfected under applicable law (including any conditional sale or other title retention agreement, any lease in the nature thereof, any option or other agreement to sell or give a security interest in and any filing of or agreement to give any financing statement under the Uniform Commercial Code (or equivalent statutes) of any jurisdiction). Notwithstanding the foregoing, (x) prior to either the No-Go Decision Date or the Final Go Decision Date, a license to any Intellectual Property for uses other than those set forth in the scope of the License Terms shall not constitute a Lien hereunder, (y) following the No-Go Decision Date with respect to a particular JV Product or JV Products, a license to any Intellectual Property with respect to such JV Product or JV Products shall not constitute a Lien hereunder, and (z) following the Final Go Decision Date with respect to a particular JV Product or JV Products, a license to any Intellectual Property with respect to such JV Product or JV Products for uses other than those set forth in the scope of the Company License Agreement, shall not constitute a Lien hereunder.
Master Framework Agreement ” shall have the meaning specified in the Agreement.
No-Go Decision Date ” has the meaning ascribed thereto in the Master Framework Agreement.
Permitted Transferees ” shall mean any Affiliate of Total Gas & Power.
Person ” means any individual, corporation, limited liability company, partnership, joint venture, association, joint-stock company, trust, unincorporated organization or government or any agency or political subdivision thereof.
Registration Rights Agreement ” means that certain Registration Rights Agreement, dated July 30, 2012, by and among the Company and the Investor.
Second Amendment ” means the Second Amendment to the Technology License, Development, Research and Collaboration Agreement entered into by the Company and the Investor, as of July 30, 2012, as such amendment may be further amended from time to time after the date hereof.
Securities Act ” means the Securities Act of 1933, as amended, and the rules and regulations promulgated thereunder.
Significant Subsidiary ” shall have the meaning specified in the Agreement.
Subsidiary ” means, with respect to any specified Person:
(1)    any corporation, association or other business entity of which more than 50% of the total voting power of shares of capital stock entitled (without regard to the occurrence of any contingency and after giving effect to any voting agreement or stockholders' agreement that effectively transfers voting power) to vote in the election of directors, managers or trustees of the corporation, association or other business entity is at the time owned or controlled, directly or indirectly, by that Person or one or more of the other Subsidiaries of that Person (or a combination thereof); and

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(2)    any partnership (a) the sole general partner or the managing general partner of which is such Person or a Subsidiary of such Person or (b) the only general partners of which are that Person or one or more Subsidiaries of that Person (or any combination thereof).
Trading Day ” means, with respect to the Common Stock, each Monday, Tuesday, Wednesday, Thursday and Friday, other than any day on which securities are not generally traded on The NASDAQ Stock Market (or its successor) or such other principal securities exchange or inter-dealer quotation system on which the shares of Common Stock are then traded.
Transfer ” means, directly or indirectly, to offer, sell (including any short sale), transfer, assign, pledge, encumber, hypothecate or similarly dispose of (by merger, testamentary disposition, operation of law or otherwise), either voluntarily or involuntarily, or enter into any contract, option or other arrangement or understanding with respect to the offer, sale (including any short sale), transfer, assignment, pledge, encumbrance, hypothecation or similar disposition of (by merger, testamentary disposition, operation of law or otherwise), any Conversion Shares “beneficially owned” (as such term is defined in Rule 13d-3 and Rule 13d-5 under the Exchange Act) by a Person or any interest (including any right to (x) all or any portion of the pecuniary interest in the security, including, without limitation, the right to receive dividends and distributions, proceeds upon liquidation and receive the proceeds of disposition or conversion (if applicable) of the security, or (y) direct the voting of the security with respect to any matter for which the security is entitled to vote) in any Conversion Shares beneficially owned by a Person. Whether or not treated as an offer or sale of the Conversion Shares under the Securities Act, “ Transfer ” shall also include any hedging or other transaction entered into after the date hereof, such as any purchase, sale (including any short sale) or grant of any right (including without limitation any put or call option) with respect to any of the Conversion Shares or with respect to any security that includes or derives any significant part of its value from such Conversion Shares.
Voting Shares ” of any person means capital shares or capital stock of such Person which ordinarily has voting power for the election of directors (or persons performing similar functions) of such person, whether at all times or only so long as no senior class of securities has such voting power by reason of any contingency.
2. Interest; Payment of Principal of Note; Cancellation of Note.

(a) Interest . This Note shall bear interest from the Issue Date on the Face Amount at a rate per annum equal to 1.50% (subject to Section 5(c)). Interest on this Note shall accrue daily and be due and payable in arrears on the Final Maturity Date and at such other times as may be specified herein. All computations of interest shall be made on the basis of a 360-day year and actual days elapsed (which results in more interest being paid than if computed on the basis of a 365-day year). Notwithstanding the foregoing, if an Event of Default shall have occurred and be continuing this Note shall bear interest on the Face Amount at a rate per annum equal to 2.50% (as may be further adjusted pursuant to Section 5(c)).

(b) Scheduled Payment of Principal . Unless paid, converted or cancelled and extinguished earlier in accordance with the terms hereof, the Company shall deliver to the

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Investor cash in the amount of the Face Amount, together with all accrued and unpaid interest on this Note, on March 1, 2017 (the “ Final Maturity Date ”).
  
(c) Contribution of Note . On the Final Go Decision Date, if any, or as otherwise provided in the Master Framework Agreement, (i) other than upon the occurrence of a Jet Go Decision, this Note and all of the Debt represented by the Face Amount, and all accrued and unpaid interest thereon, shall be exchanged for equity interests in the Joint Venture in accordance with the provisions of the Master Framework Agreement, and after such exchange this Note shall be extinguished and of no further force and effect and the Company shall have no further obligations with respect hereto, and (ii) in the event of the occurrence of a Jet Go Decision, (x) 30% of the Debt represented by the Face Amount, and all accrued and unpaid interest on such portion of such Debt, shall be exchanged for equity interests in the Joint Venture in accordance with the provisions of the Master Framework Agreement, and after such exchange the portion of this Note representing such Debt shall be extinguished and of no further force and effect and the Company shall have no further obligations with respect hereto, and (y) upon receipt of this Note from the Investor, the Company shall promptly issue and deliver to the Investor a new Note in an aggregate principal amount equal to 70% of the Debt represented by the Face Amount.

3. Conversion Rights; Adjustments. The Investor shall have conversion rights as follows (the “ Conversion Rights ”):

(a) Investor's Right to Convert . At any time (i) after the tenth Trading Day prior to the Final Maturity Date and prior to the fifth Trading Day prior to the Final Maturity Date, (ii) after the earlier to occur of (x) the occurrence of a Change of Control and (y) the date of the Company's delivery of the Change of Control Notice pursuant to Section 4(b), and in each case and prior to the fifth Trading Day prior to the Final Maturity Date, (iii) when there shall then exist a Larger Shareholder after the No-Go Decision Date, or (iv) after the occurrence of an Event of Default, the Investor shall have the right to convert the Face Amount of this Note, in whole or in part, at the option of the Investor, at any time within the period specified above into a number of fully paid and nonassessable authorized but unissued Common Stock determined by dividing (x) the Face Amount proposed to be converted at such date by (y) the then effective Conversion Price on the Conversion Date (as defined in Section 3(c)(i)) (the “ Investor Optional Conversion ”).

(b) The “Conversion Price” at which Common Stock shall be deliverable upon conversion of the Notes (the “ Conversion Price ”) shall initially be $7.0682. Such initial Conversion Price shall be subject to adjustment as provided below.

(c) Mechanics of Conversion .

(i) In order to exercise its rights pursuant to the Investor Optional Conversion, the Investor shall deliver written notice in the form of Exhibit 1 to the Company stating that the Investor elects to convert all or part of the Face Amount represented by this Note. Such notice shall state the Face Amount of Notes which the Investor seeks to convert and shall be accompanied within one (1) Trading Day by the Note or Notes subject to conversion. The date contained in the notice (which date shall be no earlier than the Trading Day immediately

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following the date of the notice) shall be the date of conversion of the Note (such date of conversion, the “ Conversion Date ”) and the Investor shall be deemed to be the beneficial owner of the underlying Common Stock as of such date.

(ii) The Investor shall be deemed to beneficially own the Common Stock underlying this Note as of the applicable Conversion Date. Not later than three (3) Trading Days following the Conversion Date, the Company shall promptly issue and deliver to the Investor a certificate or certificates for the number of shares of Common Stock to which the Investor is entitled and, in the case where only part of a Note is converted, the Company shall execute and deliver (at its own expense) a new Note of any authorized denomination as requested by the Investor in an aggregate principal amount equal to and in exchange for the unconverted portion of the principal amount of the Note so surrendered.

(iii) Upon conversion of this Note in whole or in part in accordance with the provision of Section 3(c) of this Note, the Company shall pay to the Investor, substantially concurrently with delivery of the shares of Common Stock issuable on such conversion (the “ Conversion Shares ”), any accrued and unpaid interest, through the day preceding the Conversion Date, on the portion of the Face Amount represented by this Note that has been so converted. In addition, upon conversion of this Note in whole or in part following a Change of Control the Company shall pay to the Investor, substantially concurrently with delivery of the Conversion Shares, an amount in cash equal to the interest that would have accrued at a rate per annum equal to 1.50% from such Conversion Date through the Final Maturity Date on the portion of the Face Amount represented by this Note that has been so converted if such Note (or portion of the Note) had not been converted (“ Make-Whole Interest ”). Notwithstanding the foregoing, in no event will the total amount of Make-Whole Interest exceed $19,118,030.05.

(iv) The Company shall at all times during which the Notes shall be outstanding, have and keep available out of its authorized but unissued shares, for the purpose of effecting the conversion of the outstanding Notes, such number of its duly authorized shares of Common Stock as shall from time to time be sufficient to effect the conversion of all outstanding Notes. In no event shall the Conversion Price be reduced to an amount less than the then par value of the Common Stock.

(v) No fractional shares of Common Stock shall be issued upon any conversion of the Notes pursuant to this Section 3. In lieu of fractional shares, the Company shall pay cash equal to such fraction multiplied by the Closing Price of the Common Stock on the Conversion Date.

(vi) All Notes (or the portions thereof) which shall have been surrendered for conversion as herein provided shall no longer be deemed to be outstanding and all rights with respect to such Notes, except only the right of the Investor to receive shares of Common Stock in exchange therefor, accrued and unpaid interest and Make-Whole Interest, if applicable, each as described in Section 3(b)(iii) and, if applicable, cash for any fractional shares of Common Stock. Any Notes, to the extent so converted, shall be retired and canceled.


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(vii) If any conversion pursuant to this Section 3 is in connection with an underwritten offering of securities registered pursuant to the Securities Act, the conversion may, at the option of the Investor, be conditioned upon the closing with the underwriter of the sale of the Conversion Shares issuable to the Investor pursuant to such offering, in which event the Investor shall not be deemed to have converted such Notes until immediately prior to the closing of such sale of securities.

(d) Adjustment for Share Splits and Combinations . If the Company shall at any time or from time to time after July 31, 2012 effect a subdivision of the outstanding shares of Common Stock, the Conversion Price and Conversion Price Floor (as defined in Section 3(e)) then in effect immediately before that subdivision shall be proportionately decreased. If the Company shall at any time or from time to time after July 31, 2012 combine the outstanding shares of Common Stock, the Conversion Price and Conversion Price Floor then in effect immediately before the combination shall be proportionately increased. Any adjustment under this paragraph shall become effective at the close of business on the date the subdivision or combination becomes effective.

(e) Adjustment for Certain Dividends and Distributions . In the event the Company at any time or from time to time after July 31, 2012, shall make or issue a dividend or other distribution payable in (x) additional shares of Common Stock, then and in each such event the Conversion Price shall be decreased as of the time of such issuance, by multiplying such Conversion Price by a fraction, the numerator of which shall be the total number of shares of Common Stock outstanding immediately prior to such issuance and the denominator of which shall be the total number of shares of Common Stock outstanding immediately prior to such issuance plus the number of such additional shares of Common Stock issuable in payment of such dividend or distribution; (y) in cash, then and in each such event, the Conversion Price shall be decreased as of the time of such issuance, by multiplying such Conversion Price by a fraction, the numerator of which shall be the Closing Price of the Common Stock on the Trading Day immediately preceding the ex-dividend date for such dividend and distribution minus the amount in cash per share of Common Stock that the Company dividends or distributes, and the denominator of which shall be the Closing Price of the Common Stock on the Trading Day immediately preceding the ex-dividend date for such dividend and distribution; (z) shares of capital stock of the Company, evidences of indebtedness, or any other asset (collectively, the “ Distributed Property ”), then and in each such event, the Conversion Price shall be decreased as of the time of such issuance, by multiplying such Conversion Price by a fraction, the numerator of which shall be the Closing Price of the Common Stock on the Trading Day immediately preceding the ex-dividend date for such dividend and distribution minus the fair market value (as determined in good faith by the Company's board of directors) of the Distributed Property distributed with respect to each share of Common Stock, and the denominator of which shall be the Closing Price of the Common Stock on the Trading Day immediately preceding the ex-dividend date for such dividend and distribution. Notwithstanding the foregoing, in no event shall the Conversion Price be reduced below $5.99 (as may be adjusted pursuant to Section 3(d), the “ Conversion Price Floor ”) pursuant to this clause (e). If a distribution or dividend would cause the Conversion Price to be below the Conversion Price Floor if not for the immediately preceding sentence, the Company shall allow the Investor to participate in the dividend or distribution as if it held the number of shares of Common Stock that this Note would be convertible into at the close of business on the day immediately preceding the ex-dividend date

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or effective date, as the case may be, for such distribution or dividend, and no adjustment shall be made to the Conversion Price as a result of such distribution or dividend.

(f) Adjustment for Reclassification, Exchange or Substitution . If at any time after July 31, 2012, shares of Common Stock of the Company shall be changed into the same or a different number of shares of any class or classes of shares, whether by reclassification, or otherwise (other than a subdivision or combination of shares, share dividend or reorganization, reclassification, merger, consolidation or asset sale provided for elsewhere in this Section 3), then and in each such event the Company shall enter into an amendment to supplement to this Note to provide that the Note will become convertible (subject to Section 3(a)) into the kind and amount of shares and other securities and property receivable upon such reorganization, reclassification, or other change, by holders of the number of shares of Common Stock into which this Note might have been converted immediately prior to such reorganization, reclassification, or change, all subject to further adjustment as provided herein or with respect to such other securities or property by the terms thereof.

(g) Reorganizations, Mergers, Consolidations or Asset Sales . If at any time after July 31, 2012 there is a tender offer, exchange offer, merger, consolidation, recapitalization, sale of all or substantially all of the Company's assets or reorganization involving the shares of Common Stock (collectively, a “ Capital Reorganization ”) (other than a merger, consolidation, sale of assets, recapitalization, subdivision, combination, reclassification, exchange or substitution of shares provided for elsewhere in this Section 3), as part of such Capital Reorganization, the Company shall enter into an amendment or supplement to this Note to provide that the Note will become convertible (subject to Section 3(a)) into the number of shares or other securities or property of the Company to which a holder of the number of shares of Common Stock deliverable upon conversion immediately prior to such Capital Reorganization would have been entitled on such Capital Reorganization, subject to adjustment in respect to such shares or securities by the terms thereof. In any such case, appropriate adjustment will be made in the application of the provisions of this Section 3 with respect to the rights of the Investor after the Capital Reorganization to the end that the provisions of this Section 3 (including adjustment of the Conversion Price then in effect and the number of Conversion Shares) and the provisions of the Agreement and the Registration Rights Agreement will be applicable after that event and be as nearly equivalent as practicable. In the event that the Company is not the surviving entity of any such Capital Reorganization, each Note shall become Notes of such surviving entity, with the same powers, rights and preferences as provided herein.

(h) No Impairment . The Company will not, by amendment of its Certificate of Incorporation or through any reorganization, transfer of assets, consolidation, merger, dissolution, issue or sale of securities or any other voluntary action, avoid or seek to avoid the observance or performance of any of the terms to be observed or performed hereunder by the Company, but will at all times in good faith assist in the carrying out of all the provisions of this Section 3 and in the taking of all such action as may be necessary or appropriate in order to protect the conversion rights of the Investor against impairment to the extent required hereunder.

(i) Certificate as to Adjustments or Distributions . Upon the occurrence of each adjustment of the Conversion Price or distribution to holders pursuant to this Section 3, the Company at its expense shall promptly compute such adjustment or distribution in accordance

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with the terms hereof and furnish to the Investor a certificate setting forth the terms of such adjustment or distribution and showing in detail the facts upon which such adjustment or distribution are based and shall file a copy of such certificate with its corporate records.

(j) Notice of Record Date . In the event:

(i) that the Company declares a dividend (or any other distribution) on its Common Stock payable in shares of Common Stock, securities, or other assets, rights or properties;

(ii) that the Company subdivides or combines its outstanding shares of Common Stock;

(iii) of any reclassification of the shares of Common Stock (other than a subdivision or combination of the Company's outstanding shares of Common Stock or a share dividend or share distribution thereon);

(iv) of any Capital Reorganization; or

(v) of the involuntary or voluntary dissolution, liquidation or winding up of the Company; then the Company shall cause to be filed at its principal office, and shall cause to be mailed to the Investor, at least ten (10) days prior to the record date specified in (A) below or twenty (20) days prior to the date specified in (B) below, a notice stating:

(A) the record date of such dividend, distribution, subdivision or combination, or, if a record is not to be taken, the date as of which the holders of shares of Common Stock of record to be entitled to such dividend, distribution, subdivision or combination are to be determined, or

(B) the date on which such reclassification, Capital Reorganization, dissolution, liquidation or winding up is expected to become effective, and the date as of which it is expected that holders of shares of Common Stock of record shall be entitled to exchange their shares of Common Stock for securities or other property deliverable upon such reclassification, Capital Reorganization, dissolution or winding up

(k) Notice of Adjustment to Conversion Price . The Company will provide notice to the Investor upon the occurrence of any adjustment to the Conversion Price.

(l) Lockup Agreement . In the event of an Investor Optional Conversion pursuant to clause (iii) of Section 3(a), the Investor shall not, without the prior written consent of the Company, Transfer any of the Conversion Shares other than as expressly permitted by, and in compliance with, the provisions of this Section 3(l):

(i) the Investor may Transfer any or all of its Conversion Shares to the Company or any of its Subsidiaries;


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(ii) the Investor may Transfer all or any of its Conversion Shares in a transaction exempt from the registration requirements under the Securities Act to any of its Affiliates, so long as prior to or concurrent with any such Transfer such Affiliate agrees in writing to be bound by the terms hereunder as the “Investor” and such other terms hereunder applicable to the Investor, and agrees to transfer such Conversion Shares back to the Investor if it ceases to be an Affiliate of the Investor;

(iii) the Investor may Transfer all or any of its Conversion Shares pursuant to the terms of any tender offer, exchange offer, merger, reclassification, reorganization, recapitalization or other similar transaction in which stockholders of the Company are offered, permitted or required to participate as holders of Common Stock, provided that such tender offer, exchange offer, merger, reclassification, reorganization, recapitalization or other transaction has been approved or recommended by the Board of Directors (and which at the time of Transfer continues to be approved or recommended by the Board of Directors); or

(iv) following the date that is six (6) months after the date of such Investor Optional Conversion pursuant to clause (iii) of Section 3(a), the Investor may transfer all or any of its Conversion Shares pursuant to either an effective registration statement that is effective at the time of such transfer or pursuant to Rule 144 promulgated under the Securities Act, and any successor provision thereto.

Notwithstanding anything herein to the contrary, the restrictions set forth in this Article III shall terminate (i) upon the consummation of a Change of Control, or (ii) at such time as the Investor, together with its Affiliates, “beneficially owns” (as such term is defined in Rule 13d-3 and Rule 13d-5 under the Exchange Act) in the aggregate Voting Shares of the Company (measured by voting power rather than number of shares) representing less than five percent (5%) of the total voting power of all outstanding classes of voting stock of the Company.
4. Repurchase Right Upon a Change of Control.

(a) Upon the occurrence of a Change of Control, the Investor will have the right to require the Company to repurchase all or any part of its Notes pursuant to an offer as provided in this Section 4 (the “ Change of Control Offer ”) at an offer price in cash equal to 101% of the Face Amount of its Notes, plus any accrued and unpaid interest as of the Change of Control Payment Date (as defined in Section 4(b)(i)) (the “ Change of Control Payment ”), in addition to the Investor's right to convert the Notes pursuant to Section 3 above.

(b) On or before the 30th day after a Change of Control, the Company shall give to the Investor notice (the “ Change of Control Notice ”) of the occurrence of the Change of Control and of the Investor's right to receive the Change of Control Payment arising as a result thereof. Each notice of the Investor's right to participate in the Change of Control Offer (the “ Change of Control Repurchase Right ”) shall be mailed to the Investor pursuant to Section 15 and shall state:

(i) the date on which the Notes shall be repurchased (the “ Change of Control Payment Date ”), which date shall be no earlier than 30 days and no later than 60 days from the date of the Company's delivery of the Change of Control Notice;

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(ii) the date by which the Change of Control Repurchase Right must be exercised, which date shall be no earlier than the close of business on the Trading Day immediately prior to the Change of Control Payment Date;

(iii) the amount of the Change of Control Payment;

(iv) a description of the procedure which the Investor must follow to exercise the Change of Control Repurchase Right, and the place or places where the Notes are to be surrendered for payment of the Change of Control Payment; and

(v) the Conversion Price then in effect and the place where such Notes may be surrendered for conversion.

No failure by the Company to give the Change of Control Notice and no defect in any Change of Control Notice shall limit the Investor's right to exercise its Change of Control Repurchase Right or affect the validity of the proceedings for the repurchase of Notes. If any of the foregoing provisions or other provisions of this Section 4 are inconsistent with applicable law, such law shall govern.
(c) To exercise the Change of Control Repurchase Right, the Investor shall deliver to the Company, on or before the Trading Day immediately prior to the Change of Control Payment Date, (i) written notice of the Investor's exercise of such right, which notice shall set forth the name of the Investor, the Face Amount of Notes held by the Investor to be repurchased, and a statement that an election to exercise the Change of Control Repurchase Right is being made thereby, and (ii) the Notes with respect to which the Change of Control Repurchase Right is being exercised. Such written notice shall be irrevocable, except that the right of the Investor to convert the Notes shall continue until midnight (Eastern Time) on the Trading Day immediately preceding the Change of Control Repurchase Date.

(d) On the Change of Control Payment Date, the Company will (i) accept for payment all Notes or portions thereof properly tendered pursuant to the Change of Control Offer and (ii) deliver cash in the amount of the Change of Control Payment to the Investor in respect of all Notes or portions thereof so tendered. All Notes repurchased by the Company shall be canceled immediately by the Company

(e) The Company shall publicly announce the results of the Change of Control Offer on or as soon as practicable after the Change of Control Payment Date.

(f) The Company will comply with the requirements of Rule 14e-1 under the Exchange Act and any other securities laws and regulations thereunder to the extent such laws and regulations are applicable in connection with the repurchase of the Notes as a result of a Change of Control.

(g) Any Note which is to be repurchased only in part shall be surrendered to the Company and the Company shall execute and make available for delivery to the Investor without service charge, a new Note or Notes, containing identical terms and conditions, each in an authorized denomination in aggregate principal amount equal to and in exchange for the

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unrepurchased portion of the principal of the Note so surrendered. Any Notes surrendered to the Company pursuant to the provisions of this Section 4 shall be retired and cancelled.

(h) The Company will not be required to make a Change of Control Offer upon a Change of Control if a third party makes the Change of Control Offer in the manner, at the times and otherwise in compliance with the requirements set forth in this Section 4 applicable to a Change of Control Offer made by the Company and purchases all Notes validly tendered and not withdrawn under such Change of Control Offer.

5. Events of Default. Definitions . For purposes of this Note, the following events shall constitute an “ Event of Default ”:

(i) default in payment when due (whether at the Final Maturity Date or upon an earlier repurchase) of the principal of, or premium, if any, on this Note;

(ii) default in the payment of an installment of interest on the Notes, which failure continues for thirty (30) days after the date when due;

(iii) failure by the Company for thirty (30) days after notice from the Investor to comply with the provisions of Section 4 or Section 6 of this Note;

(iv) failure by the Company for sixty (60) days after notice from the Investor to comply with any of its other agreements in this Note or the Agreement (other than Section 8.6(b) of the Agreement);

(v) default under any mortgage, indenture or instrument under which there may be issued or by which there may be secured or evidenced any Debt for money borrowed by the Company (or the payment of which is guaranteed by the Company, whether such Debt or guarantee now exists, or is created after the date of the Issue Date, which default (a) is caused by a failure to pay principal of or premium, if any, or interest on such Debt prior to the expiration of the grace period provided in such Debt on the date of such default or (b) results in the acceleration of such Debt prior to its express maturity and, in each case in clause (a) or (b), the principal amount of any such Debt, together with the principal amount of any other such Debt that has not been paid when due, or the maturity of which has been so accelerated, aggregates $10,000,000 or more;

(vi) failure by the Company to pay final judgments aggregating in excess of $10,000,000, which judgments are not paid, discharged or stayed for a period of sixty (60) days;

(vii) the Company:

(A) commences a voluntary case under any Bankruptcy Law,

(B) consents to the entry of an order for relief against it in an involuntary case under any Bankruptcy Law,


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(C) consents to the appointment of a custodian of it or for all or substantially all of its property,

(D) makes a general assignment for the benefit of its creditors, or

(E) is unable to pay its debts as they become due; or

(viii) a court of competent jurisdiction enters an order or decree under any Bankruptcy Law that:

(A) is for relief against the Company;

(B) appoints a custodian of the Company or any of its Significant Subsidiaries or for all or substantially all of the property of the Company; or

(C) orders the liquidation of the Company and the order or decree remains unstayed and in effect for sixty (60) consecutive days; or

(ix)    failure by the Company to deliver when due the consideration deliverable upon conversion of this Note, which failure shall continue for a period of five days.
(b) Notice of Compliance . The Company shall be required to deliver to the Investor annually a statement regarding compliance with this Note, and the Company shall be required within five (5) days of becoming aware of any Default or Event of Default (or such earlier date as any such statement is provided to the holders of the Debt incurred pursuant to the Securities Purchase Agreement dated as of February 24, 2012) to deliver to the Investor a statement specifying such Default or Event of Default.

(c) Acceleration . If any Event of Default occurs and is continuing, the Investor may declare all the Notes to be due and payable immediately. Notwithstanding the foregoing, in the case of an Event of Default described in Section 5(vii) or (viii) with respect to the Company all outstanding Notes will become due and payable without further action or notice. The Investor may rescind an acceleration and its consequences if the rescission would not conflict with any judgment or decree. Notwithstanding the foregoing (or anything to the contrary in the Agreement), the sole remedy of the Investor for a failure by the Company to comply with Section 8.6(b) of the Agreement shall, for the first 365 days after the occurrence of such failure, be the right, by notice to the Company by the Investor, to increase in the rate of interest on this Note to 6% for the first 180 days of such failure, and to 9% thereafter (which increased interest shall constitute liquidated damages for such failure).

(d) Waiver of Past Defaults . The Investor may waive any existing Default or Event of Default and its consequences under this Note. Upon any such waiver, such Default shall cease to exist, and any Event of Default arising therefrom shall be deemed to have been cured for every purpose of this Note, but no such waiver shall extend to any subsequent or other default or impair any right consequent thereon.

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(e) Rights of Investor to Receive Payment . Notwithstanding any other provision of this Note, the right of the Investor to receive payment of the principal of, and premium on, this Note, on or after the respective due dates expressed in the Note (including in connection with a redemption or an offer to purchase), or to bring suit for the enforcement of any such payment on or after such respective dates, shall not be impaired or affected without the consent of the Investor

6. Limitation on Debt and Liens. The Company will not, and will not permit its Subsidiaries to, directly or indirectly, create, incur, issue, assume, guarantee or otherwise become directly or indirectly liable, contingently or otherwise, with respect to any Debt, and the Company will not issue any Disqualified Stock and the Company will not permit its Subsidiaries to issue shares of preferred stock except for:

(a) Debt in an amount outstanding at any time not to exceed the greater of (i) $200 million in aggregate principal amount or (ii) 50% of the Company's total consolidated assets (as set forth on its most recent balance sheet prepared in accordance with GAAP and filed with the Securities and Exchange Commission after giving effect to any reductions or additions to assets in accordance with GAAP since the date of such balance sheet) (and provided that Debt incurred pursuant to this clause (a) that is secured by a Lien on assets of the Company shall not exceed the greater of (i) $125 million in aggregate principal amount or (ii) 30% of the Company's total consolidated assets (as set forth on its most recent balance sheet prepared in accordance with GAAP); provided that neither the Company nor any of its Subsidiaries shall incur any Debt pursuant to this clause 6(a) if the issuance of such Debt would prohibit the Company from issuing the maximum amount of Notes to be issued by the Company under the Agreement;

(b) Debt in existence on February 27, 2012;

(c) the incurrence by the Company or any of its Subsidiaries of Debt represented by Capital Lease Obligations, mortgage financings or purchase money obligations, in each case, incurred for the purpose of financing all or any part of the purchase price or cost of design, construction, installation or improvement of property, plant or equipment used in the business of the Company or any of its Subsidiaries.

(d) Debt of the Company that is (i) contractually subordinated in right of payment to the Notes, (ii) matures 91 days after the Notes and (iii) is less than $50 million in aggregate principal amount at any one time outstanding;

(e) Debt of the Company (A) in respect of performance, surety or appeal bonds or letters of credit in the ordinary course of business, or (B) under interest rate, currency, commodity or similar hedges, swaps and other derivatives entered into with one or more financial institutions that is designed to protect such the Company against fluctuations in interest rates or currency exchange rates, commodity prices or other market fluctuations and is not entered into for speculative purposes; and

(f) Debt which is exchanged for or the proceeds of which are used to refinance or refund, or any extension or renewal of (each a "refinancing"), (1) the Notes or (2)

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debt in existence on the Issue Date, and (3) Debt incurred pursuant to clause (c) of this paragraph, in each case in an aggregate principal amount not to exceed the principal amount of the Debt so refinanced (together with any accrued interest and any premium and other payment required to be made with respect to the Debt being refinanced or refunded, and any fees, costs, expenses, underwriting discounts or commissions and other payments paid or payable with respect to the Debt incurred pursuant to this clause (f)); provided, however, that (A) Debt, the proceeds of which are used to refinance the Notes, or Debt which is pari passu with the Notes (including Debt incurred pursuant to the Securities Purchase Agreement, dated as of February 24, 2012, among the Company and the purchasers named therein) or subordinate in right of payment to the Notes, shall only be permitted if (x) in the case of any refinancing of the Notes or Debt which is pari passu to the Notes (including Debt incurred pursuant to the Securities Purchase Agreement, dated as of February 24, 2012, among the Company and the purchasers named therein), the refinancing Debt is Incurred by the Company and made pari passu to the Notes or subordinated to the Notes, and (y) in the case of any refinancing of Debt which is subordinated to the Notes, the refinancing Debt is incurred by the Company and is subordinated to the Notes in a manner that is at least as favorable to the Investor as that of the Debt refinanced; (B) refinancing Debt with respect to Debt incurred pursuant to clause (c) of this paragraph shall not be secured by a Lien on any assets other than the assets securing the Debt so refinanced, and any improvements or additions thereto, and (C) the refinancing Debt by its terms, or by the terms of any agreement or instrument pursuant to which such Debt is issued, does not have a final maturity prior to the final maturity of the Debt being refinanced.
For purposes of determining compliance with this Section 6, in the event that an item of Debt meets the criteria of more than one of the types of Debt described in the above clauses the Company, in its sole discretion, shall classify, and from time to time may reclassify, such item of Debt.
(g) The Company will not create, incur, assume or suffer to exist any Lien of any kind on any asset now owned or hereafter acquired, except for (a) the Liens described in Section 6(a) and 6(c) (including the refinancing of Liens described in Section 6(c) pursuant to Section 6(f)), (b) Permitted Liens, and (c) any Liens in existence on the Issue Date (including the refinancing thereof pursuant to Section 6(f)). Notwithstanding the foregoing, without the prior written consent of the Investor, which consent shall not be unreasonably withheld, the Company will not create, incur, assume or suffer to exist any Lien of any kind on any of its Intellectual Property that is subject to or within the scope of the License Terms, unless the secured party acknowledges in writing that its Lien shall not restrict the Company from granting and performing its obligations under any license agreement entered into in accordance with the License Terms, and that the rights of the secured party under its Lien shall be subordinate and subject to the rights of the licensees under any such licenses, and (ii) there shall be no restriction on the ability of the Company to create, incur, assume or suffer to exist any Lien of any kind on any of its Intellectual Property that is not subject to or within the scope of the License Terms or, once executed, the Company License Agreement.

As used herein, “ Permitted Liens ” means the following: (a) Liens for taxes, assessments and governmental charges or levies that are not overdue for a period of more than thirty (30) days or which are being contested in good faith; (b) Liens imposed by law, such as materialmen's, mechanics', carriers', workmen's and repairmen's Liens and other similar Liens

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securing obligations that are not overdue for a period of more than thirty (30) days or that are being contested in good faith; (c) pledges or deposits to secure obligations under workers' compensation laws or similar legislation or to secure public or statutory obligations; (d) easements, rights of way and other encumbrances on title to real property that do not render title to the property encumbered thereby unmarketable or materially adversely affect the use of such property for its present purposes; (e) Liens to secure the performance of bids, trade contracts, leases, statutory obligations, surety and appeal bonds, performance bonds and other obligations of a like nature; (f) landlords' Liens under leases; (g) Liens consisting of leases, subleases, licenses or sublicenses granted to others and not interfering in any material respect with the business of the Company and its Subsidiaries, taken as a whole, and any interest or title of a lessor or licensor under any lease or license, as applicable; (h) Liens arising solely by virtue of any statutory or common law provision relating to banker's Liens, rights of set-off or similar rights and remedies as to deposit accounts or other funds maintained with a creditor depository institution; and (i) Liens securing judgments for the payment of money not constituting an Event of Default under Section 5(a)(vi) or securing appeal or other surety bonds related to such judgments.
7. Successors.

(a) Merger, Consolidation or Sale of Assets . The Company shall not consolidate or merge with or into (whether or not the Company is the surviving corporation), or sell, assign, transfer, lease, convey or otherwise dispose of all or substantially all of its properties or assets in one or more related transactions, to another corporation, Person or entity unless:

(i) the entity or Person formed by or surviving any such consolidation or merger (if other than the Company), or the parent company thereof, or the entity or Person to which such sale, assignment, transfer, lease, conveyance or other disposition shall have been made assumes all the obligations of the Company under the Notes and the Agreement; and

(ii) immediately after such transaction no Default or Event of Default exists.

(b) Successor Corporation Substituted . Upon any consolidation or merger or any transfer of all or substantially all of the assets of the Company in accordance with Section 7(a) hereof, the successor Person formed by such consolidation or into which the Company is merged, or the parent company thereof, or to which such transfer is made shall succeed to and (except in the case of a lease) be substituted for (so that from and after the date of such consolidation, merger or transfer, the provisions of this Note, the Agreement and the Registration Rights Agreement referring to the “Company” shall refer instead to the successor Person and not to the Company), and may exercise every right and power of, the Company under this Note and the Agreement with the same effect as if such successor Person had been named herein as the Company, and (except in the case of a lease) the Company shall be released from the obligations under the Notes and the Agreement except with respect to any obligations that arise from, or are related to, such transaction.

8. Amendment and Waiver. Except as otherwise expressly provided herein, the provisions of this Note may be amended and the Company may take any action herein

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prohibited, or omit to perform any act herein required to be performed by it, only if the Company has obtained the written consent of the Investor.

9. Place of Payment. Payments of principal, interest, and premium, if any, consideration deliverable upon conversion of this Note (unless otherwise specified in the conversion notice) and all notices and other communications to the Investor hereunder or with respect hereto are to be delivered to the Investor at the address identified in the Agreement or to such other address or to the attention of such other person as specified by prior written notice to the Company, including any Permitted Transferee of this Note in accordance with Section 3 of this Note.

10. Costs of Collection. In the event that the Company fails to (a) pay when due (including, without limitation upon acceleration in connection with an Event of Default) the full amount of principal, interest and/or premium hereunder or (b) deliver when due the consideration deliverable upon conversion of this Note, the Company shall indemnify and hold harmless the Investor of any portion of this Note from and against all reasonable costs and expenses incurred in connection with the enforcement of this provision or collection of such principal, interest, premium and/or consideration, including, without limitation, reasonable attorneys' fees and expenses.

11. Waivers. The Company hereby waives presentment, demand, notice, protest and all other demands and notices in connection with the delivery, acceptance, performance, default or enforcement of this Note.

12. Benefits of the Agreement. The Investor and all transferees of this Note (to the extent such transfer is permitted by the Agreement) shall be entitled to the rights and benefits granted to them in the Agreement.

13. Registration of Transfer and Exchange Generally.

(a) Registration, Registration of Transfer and Exchange Generally . The Company shall keep at its principal executive offices a register (the register maintained in such being herein sometimes collectively referred to as the “ Note Register ”) in which the Company shall provide for the registration of Notes and of transfers and exchanges of Notes.

Subject to the provisions of the Agreement regarding restrictions on transfer and provided the Permitted Transferee agrees to be bound by the terms of this Note and the Agreement, upon surrender for registration of transfer of any Note at its principal executive office, the Company shall execute and deliver, in the name of the designated transferee or transferees, one or more new Notes in denominations requested by the transferee (which denominations shall not be less than $1,000,000 per Note (unless the transferor holds a lesser denomination, in which case no such restriction shall apply)), of a like aggregate principal amount and bearing such restrictive legends as may be required by law.
At the option of the Investor, Notes may be exchanged for other Notes of any authorized denominations, of a like aggregate principal amount and bearing such restrictive legends as may be required by law upon surrender of the Notes to be exchanged at the Company's principal executive offices. Whenever any Notes are so surrendered for exchange, the Company shall

19



execute and make available for delivery the Notes that the Investor making the exchange is entitled to receive.
All Notes issued upon any registration of transfer or exchange of Notes shall be the valid obligations of the Company, evidencing the same debt, and entitled to the same benefits as the Notes surrendered upon such registration of transfer or exchange.
Every Note presented or surrendered for registration of transfer or for exchange shall (if so required by the Company) be duly endorsed, or be accompanied by a written instrument of transfer in form satisfactory to the Company, duly executed by the Investor.
No service charge shall be made for any registration of transfer or exchange of Notes.
(b) Mutilated, Destroyed, Lost and Stolen Notes . If any mutilated Note is surrendered to the Company, the Company shall execute and make available for delivery in exchange therefor a new Note of like tenor and principal amount and bearing a number not contemporaneously outstanding.

If there shall be delivered to the Company (i) evidence to its reasonable satisfaction of the destruction, loss or theft of any Note and (ii) such indemnity as may be reasonably requested by the Company to save itself harmless, then, in the absence of notice to the Company that such Note has been acquired by a protected purchaser, the Company shall execute and make available for delivery, in lieu of any such destroyed, lost or stolen Note, a new Note of like tenor and principal amount and bearing a number not contemporaneously outstanding.
Every new Note issued pursuant to this Section 13 in lieu of any mutilated, destroyed, lost or stolen Note shall constitute an original additional contractual obligation of the Company, whether or not the destroyed, lost or stolen Note shall be at any time enforceable by anyone.
The provisions of this Section 13 are exclusive and shall preclude (to the extent lawful) all other rights and remedies with respect to the replacement or payment of mutilated, destroyed, lost or stolen Notes.
14. Governing Law.

(a)    THIS NOTE, AND THE PROVISIONS, RIGHTS, OBLIGATIONS, AND CONDITIONS SET FORTH HEREIN, AND THE LEGAL RELATIONS BETWEEN THE PARTIES HERETO, INCLUDING ALL DISPUTES AND CLAIMS, WHETHER ARISING IN CONTRACT, TORT, OR UNDER STATUTE, SHALL BE GOVERNED BY AND CONSTRUED IN ACCORDANCE WITH THE LAWS OF THE STATE OF NEW YORK WITHOUT GIVING EFFECT TO ITS CONFLICT OF LAW PROVISIONS.
(b)    Any and all disputes arising out of, or in connection with, the interpretation, performance, or nonperformance of this Note or any and all disputes arising out of, or in connection with, transactions in any way related to this Note and/or the relationship between the parties shall be litigated solely and exclusively before the United States District Court for the Southern District of New York. The parties consent to the in personam jurisdiction of said court for the purposes of any such litigation, and waive, fully and completely, any right to

20



dismiss and/or transfer any action pursuant to 28 U.S.C. § 1404 or 1406 (or any successor statute). In the event the United States District Court for the Southern District of New York does not have subject matter jurisdiction of said matter, then such matter shall be litigated solely and exclusively before the appropriate state court of competent jurisdiction located in the state of New York.
15. Notices. All notices, requests, and other communications hereunder shall be in writing and will be deemed to have been duly given and received (a) when personally delivered, (b) when sent by facsimile upon confirmation of receipt, (c) one business day after the day on which the same has been delivered prepaid to a nationally recognized courier service, or (d) five business days after the deposit in the United States mail, registered or certified, return receipt requested, postage prepaid, in each case to the applicable address set forth below:

(i) if to the Company, to:
Amyris, Inc.
5885 Hollis Street, Suite 100
Emeryville, CA 94608
United States of America
Attn:     General Counsel
Fax. No.: +1 (510) 842-1460
with a copy (which shall not constitute notice) to:

Shearman & Sterling LLP
Four Embarcadero Center, Suite 3800
San Francisco, CA  94111-5994
United States of America
Attn:    Michael S. Dorf
Fax. No.: +1 (415) 616-1446

(ii) if to the Investor, to:
Total Gas & Power USA, SAS
2, place Jean Millier
La Défense 6
92400 Courbevoie
France
Attn:     Bernard Clément
Fax. No.: +331 4744 8178


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with a copy (which shall not constitute notice) to:
Wilson Sonsini Goodrich & Rosati
Professional Corporation
650 Page Mill Road
Palo Alto, CA 94304
United States of America
Attn:     David J. Segre
Michael A. Occhiolini
Richard Cameron Blake
Fax No.: +1 (650) 493-6811
Any party hereto from time to time may change its address, facsimile number, or other information for the purpose of notices to that party by giving notice specifying such change to the other parties hereto. The Investor and the Company may each agree in writing to accept notices and other communications to it hereunder by electronic communications pursuant to procedures reasonably approved by it; provided that approval of such procedures may be limited to particular notices or communications.

[Signature Page Follows]


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IN WITNESS WHEREOF, the Company has executed and delivered this Note on July 30, 2012.

AMYRIS, INC.
By: /s/ John Melo    
Name: John Melo
Title: President and Chief Executive Officer


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EXHIBIT 1
(To be Executed by Investor in order to Convert Note)
CONVERSION NOTICE
FOR
1.5% SENIOR UNSECURED CONVERTIBLE NOTE DUE 2017
The undersigned, as holder of the 1.5% Senior Unsecured Convertible Note due 2017 of AMYRIS, INC ., (the “ Company ”), in the outstanding principal amount of U.S. $38,300,000 (the “ Note ”), hereby elects to convert that portion of the outstanding principal amount of the Note shown on the next page into shares of the Company's common stock, $0.0001 par value per share (the “ Common Stock ”), of the Company, accrued and unpaid interest and Make-Whole Interest, if any, in accordance with and in compliance with the conditions of the Note, as of the date written below. The undersigned hereby requests that share certificates for the shares of Common Stock to be issued to the undersigned pursuant to this Conversion Notice be issued in the name of, and delivered to, the undersigned or its designee as indicated below. If shares are to be issued in the name of a person other than the undersigned, the undersigned will pay all transfer taxes payable with respect thereto. No fee will be charged to the Investor for any conversion, except for transfer taxes, if any.
Conversion Information      TOTAL GAS & POWER USA, SAS:
By:     
Print Name:
Print Title:
Address:
2, Place Jean Millier
La Défense 6
92400 Courbevoie
France
Attn: Bernard Clément
Fax. No.: +331 4744 8178
    

Issue Common Stock:     
at:     

Date of Conversion
    
Applicable Conversion Price
    





THE COMPUTATION OF THE NUMBER OF SHARES OF COMMON STOCK TO
BE RECEIVED IS SET FORTH ON THE ATTACHED PAGE

Page 2 to Conversion Notice for: Total Gas & Power USA, SAS    


COMPUTATION OF NUMBER OF COMMON SHARES TO BE RECEIVED
Face Amount converted:
 
$
 
 
 
 
 
Conversion Price
 
$
 
 
 
 
 
Number of shares of Common Stock =
Total dollar amount converted    =
$
 
 
Conversion Price
 
 
Number of shares of Common Stock =
 
 
 
 
 
 
 
Please issue and deliver ___ certificate(s) for shares of Common Stock in the following amount(s):
 
 
 
 
Please issue and deliver ___ new Note(s) in the following amounts:
 
 
 






Schedule A

Notes Issued by Registrant
Note Number
Date of Note
Amount
Conversion Price
R-1
July 30, 2012
$38,300,000
$7.0682
R-2
September 14, 2012
$15,000,000
$7.0682






EXECUTION COPY

REGISTRATION RIGHTS AGREEMENT
This Registration Rights Agreement (this “ Agreement ”) is made and entered into as of July 30, 2012, by and among Amyris, Inc. a Delaware corporation (the “ Company ”), and Total Gas & Power USA, SAS, a société par actions simplifiée organized under the laws of the Republic of France (the “ Investor ”).
This Agreement is made pursuant to the Securities Purchase Agreement, dated as of July 30, 2012 between the Company and the Investor (the “ Purchase Agreement ”) pursuant to which the Investor has purchased and has agreed to subsequently purchase, subject to the terms and conditions of the Purchase Agreement, Convertible Senior Notes due 2017 (the “ Convertible Notes ”) which are convertible into Common Stock (as defined below).
NOW, THEREFORE, IN CONSIDERATION of the mutual covenants contained in this Agreement, and for other good and valuable consideration, the receipt and adequacy of which are hereby acknowledged, the Company and the Investor agree as follows:
1. Definitions . Capitalized terms used and not otherwise defined herein that are defined in the Purchase Agreement shall have the meanings given such terms in the Purchase Agreement. As used in this Agreement, the following terms shall have the following meanings:

Advice ” has the meaning set forth in Section 6(c) .
Affiliate ” means, with respect to any person, any other person which directly or indirectly controls, is controlled by, or is under common control with, such person.
Agreement ” has the meaning set forth in the Preamble.
Business Day ” means a day, other than a Saturday or Sunday, on which banks in New York City are open for the general transaction of business.
Commission ” means the Securities and Exchange Commission.
Common Stock ” means the common stock of the Company, par value $0.0001 per share, and any securities into which such common stock may hereinafter be reclassified.
Company ” has the meaning set forth in the Preamble.
Effective Date ” means the date that the Registration Statement filed pursuant to Section 2(a) is first declared effective by the Commission.
Effectiveness Deadline ” means, with respect to the Initial Registration Statement or the New Registration Statement, the seventieth (70 th ) calendar day following the Filing Deadline (or, in the event the Commission reviews and has written comments to the Initial Registration Statement or the New Registration Statement, the one hundredth (100 th ) calendar day following the Filing Deadline); provided, however , that if the Company is notified by the Commission that the Initial Registration Statement or the New Registration Statement will not be reviewed or is no longer subject to further review and comments, the Effectiveness Deadline as to such Registration Statement shall be the fifth (5 th ) Trading Day following the date on which the Company is so notified if such date precedes the dates otherwise required above;

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provided, further , that if the Effectiveness Deadline falls on a Saturday, Sunday or other day that the Commission is closed for business, the Effectiveness Deadline shall be extended to the next Business Day on which the Commission is open for business.
Effectiveness Period ” has the meaning set forth in Section 2(b) .
Event ” has the meaning set forth in Section 2(c) .
Event Date ” has the meaning set forth in Section 2(c) .
Exchange Act ” means the Securities Exchange Act of 1934, as amended, and the rules and regulations promulgated thereunder.
Filing Deadline ” means, with respect to the Initial Registration Statement required to be filed pursuant to Section 2(a) , the earlier to occur of (i) the twentieth (20th) calendar day before the Final Maturity Date (as defined in the Convertible Notes) and (ii) in the event that the Investor exercises its right to convert any of its Convertible Notes pursuant to Section 3(a) of such Convertible Note, within ninety (90) days following any such optional conversion; provided, however , that if the Filing Deadline falls on a Saturday, Sunday or other day that the Commission is closed for business, the Filing Deadline shall be extended to the next business day on which the Commission is open for business.
Indemnified Party ” has the meaning set forth in Section 5(c) .
Indemnifying Party ” has the meaning set forth in Section 5(c) .
Initial Registration Statement ” means the initial Registration Statement filed pursuant to Section 2(a) of this Agreement.
Investor ” has the meaning set forth in the Preamble.
“Liquidated Damages” has the meaning set forth in Section 2(c) .
“Losses ” has the meaning set forth in Section 5(a) .
New Registration Statement ” has the meaning set forth in Section 2(a) .
Person ” means an individual or corporation, partnership, trust, incorporated or unincorporated association, joint venture, limited liability company, joint stock company, government (or an agency or subdivision thereof) or other entity of any kind.
Principal Market ” means the Trading Market on which the Common Stock is primarily listed on and quoted for trading, which, as of the Filing Deadline, shall be the NASDAQ Global Select Market.
Proceeding ” means an action, claim, suit, investigation or proceeding (including, without limitation, an investigation or partial proceeding, such as a deposition), whether commenced or threatened.
Prospectus ” means the prospectus included in a Registration Statement (including, without limitation, a prospectus that includes any information previously omitted from a prospectus filed as part of an effective registration statement in reliance upon Rule 430A promulgated under the Securities Act), as amended or supplemented by any prospectus supplement, with respect to the terms of the offering

2



of any portion of the Registrable Securities covered by a Registration Statement, and all other amendments and supplements to the Prospectus, including post-effective amendments, and all material incorporated by reference or deemed to be incorporated by reference in such Prospectus.
Purchase Agreement ” has the meaning set forth in the Recitals.
Registrable Securities ” means all of (i) the Shares, and (ii) any securities issued or issuable upon any stock split, dividend or other distribution, recapitalization or similar event with respect to the foregoing provided , that the Investor has completed and delivered to the Company a Selling Stockholder Questionnaire; and provided, further , that the Shares shall cease to be Registrable Securities upon the earliest to occur of the following: (A) a sale pursuant to a Registration Statement or Rule 144 under the Securities Act (in which case, only such security sold by the Investor shall cease to be a Registrable Security); or (B) becoming eligible for resale by the Investor under Rule 144 without the requirement for the Company to be in compliance with the current public information required thereunder and without volume or manner-of-sale restrictions, pursuant to a written opinion letter to such effect, addressed, delivered and acceptable to the Transfer Agent..
Registration Statements ” means any one or more registration statements of the Company filed under the Securities Act that covers the resale of any of the Registrable Securities pursuant to the provisions of this Agreement (including without limitation the Initial Registration Statement, the New Registration Statement and any Remainder Registration Statements), amendments and supplements to such Registration Statements, including post-effective amendments, all exhibits and all material incorporated by reference or deemed to be incorporated by reference in such Registration Statements.
Remainder Registration Statement ” has the meaning set forth in Section 2(a) .
Rule 144 ” means Rule 144 promulgated by the Commission pursuant to the Securities Act, as such Rule may be amended from time to time, or any similar rule or regulation hereafter adopted by the Commission having substantially the same effect as such Rule.
Rule 415 ” means Rule 415 promulgated by the Commission pursuant to the Securities Act, as such Rule may be amended from time to time, or any similar rule or regulation hereafter adopted by the Commission having substantially the same effect as such Rule.
Rule 424 ” means Rule 424 promulgated by the Commission pursuant to the Securities Act, as such Rule may be amended from time to time, or any similar rule or regulation hereafter adopted by the Commission having substantially the same effect as such Rule.
SEC Guidance ” means (i) any publicly-available written or oral guidance, comments, requirements or requests of the Commission staff and (ii) the Securities Act.
Securities Act ” means the Securities Act of 1933, as amended, and the rules and regulations promulgated thereunder.
Selling Stockholder Questionnaire ” means a questionnaire in the form attached as Annex B hereto, or such other form of questionnaire as may reasonably be proposed by the Investor and reasonably acceptable to the Company.
Shares ” means the shares of Common Stock issued or issuable to the Investor upon conversion of the Convertible Notes.

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Trading Day ” means (i) a day on which the Common Stock is listed or quoted and traded on its Principal Market (other than the OTC Bulletin Board), or (ii) if the Common Stock is not listed on a Trading Market (other than the OTC Bulletin Board), a day on which the Common Stock is traded in the over‑the‑counter market, as reported by the OTC Bulletin Board, or (iii) if the Common Stock is not quoted on any Trading Market, a day on which the Common Stock is quoted in the over‑the‑counter market as reported in the “pink sheets” by Pink Sheets LLC (or any similar organization or agency succeeding to its functions of reporting prices); provided , that in the event that the Common Stock is not listed or quoted as set forth in (i), (ii) and (iii) hereof, then Trading Day shall mean a Business Day.
Trading Market ” means whichever of the New York Stock Exchange, the American Stock Exchange, the NASDAQ Global Select Market, the NASDAQ Global Market, the NASDAQ Capital Market or OTC Bulletin Board on which the Common Stock is listed or quoted for trading on the date in question.
2. Registration .

(a) On or prior to the Filing Deadline, the Company shall prepare and file with the Commission a Registration Statement covering the resale of all of the Registrable Securities not already covered by an existing and effective Registration Statement for an offering to be made on a continuous basis pursuant to Rule 415 or, if Rule 415 is not available for offers and sales of the Registrable Securities, by such other means of distribution of Registrable Securities as the Investor may reasonably specify (the “ Initial Registration Statement ”). The Initial Registration Statement shall be on Form S-3 (except if the Company is then ineligible to register for resale the Registrable Securities on Form S-3, in which case such registration shall be on such other form available to register for resale the Registrable Securities as a secondary offering) subject to the provisions of Section 2(e) and shall contain (except if otherwise required pursuant to written comments received from the Commission upon a review of such Registration Statement) the “Plan of Distribution” section attached hereto as Annex A (which may be modified to respond to comments, if any, provided by the Commission). Notwithstanding the registration obligations set forth in this Section 2 , in the event the Commission informs the Company that all of the Registrable Securities cannot, as a result of the application of Rule 415, be registered for resale as a secondary offering on a single registration statement, the Company agrees to promptly (i) inform the Investor thereof and use its commercially reasonable efforts to file amendments to the Initial Registration Statement as required by the Commission and/or (ii) withdraw the Initial Registration Statement and file a new registration statement (a “ New Registration Statement ”), in either case covering the maximum number of Registrable Securities permitted to be registered by the Commission, on Form S-3 or such other form available to register for resale the Registrable Securities as a secondary offering; provided, however , that prior to filing such amendment or New Registration Statement, the Company shall be obligated to use its commercially reasonable efforts to advocate with the Commission for the registration of all of the Registrable Securities in accordance with the SEC Guidance, including without limitation, the Manual of Publicly Available Telephone Interpretations D.29. Notwithstanding any other provision of this Agreement and subject to the payment of liquidated damages in Section 2(c) , if any SEC Guidance sets forth a limitation of the number of Registrable Securities permitted to be registered on a particular Registration Statement as a secondary offering (and notwithstanding that the Company used diligent efforts to advocate with the Commission for the registration of all or a greater number of Registrable Securities), unless otherwise directed in writing by the Investor, the number of Registrable Securities to be registered on such Registration Statement will first be reduced by Registrable Securities not acquired pursuant to the Purchase Agreement (whether pursuant to registration rights or otherwise), and second by Registrable Securities represented by the Shares held by the Investor (or by the Shares that would be held by the Investor if the Convertible Notes were converted). In the event the Company amends the Initial Registration Statement or files a New Registration Statement, as the case may be, under clauses (i) or (ii)

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above, the Company will use its commercially reasonable efforts to file with the Commission, as promptly as allowed by Commission or SEC Guidance provided to the Company or to registrants of securities in general, one or more registration statements on Form S-3 or such other form available to register for resale those Registrable Securities that were not registered for resale on the Initial Registration Statement, as amended, or the New Registration Statement (the “ Remainder Registration Statements ”).

(b) The Company shall use its commercially reasonable efforts to cause each Registration Statement to be declared effective by the Commission as soon as practicable and, with respect to the Initial Registration Statement or the New Registration Statement, as applicable, no later than the Effectiveness Deadline (including filing with the Commission a request for acceleration of effectiveness in accordance with Rule 461 promulgated under the Securities Act), and shall use its commercially reasonable efforts to keep each Registration Statement continuously effective under the Securities Act until the earlier of (i) such time as all of the Registrable Securities covered by such Registration Statement have been publicly sold by the Investor or (ii) the date that all Registrable Securities covered by such Registration Statement may be sold by non-affiliates without volume or manner-of-sale restrictions pursuant to Rule 144, without the requirement for the Company to be in compliance with the current public information requirement under Rule 144 as determined by counsel to the Company pursuant to a written opinion letter to such effect, addressed and reasonably acceptable to the Company's transfer agent (the “ Effectiveness Period ”). The Company shall telephonically request effectiveness of a Registration Statement as of 5:00 P.M. New York City time on a Trading Day. The Company shall promptly notify the Investor via facsimile or electronic mail of a “.pdf” format data file of the effectiveness of a Registration Statement on the same Trading Day that the Company telephonically confirms effectiveness with the Commission, which date of confirmation shall initially be the date requested for effectiveness of such Registration Statement. The Company shall, by 9:30 A.M. New York City time on the first Trading Day after the Effective Date, file a final Prospectus with the Commission, as required by Rule 424(b). Failure to so notify the Investor on or before the second Trading Day after such notification or effectiveness or failure to file a final Prospectus as aforesaid shall be deemed an Event under Section 2(c) .

(c) If: (i) the Initial Registration Statement is not filed with the Commission on or prior to the Filing Deadline, (ii) the Initial Registration Statement or the New Registration Statement, as applicable, is not declared effective by the Commission (or otherwise does not become effective) for any reason on or prior to the Effectiveness Deadline or (iii) after its Effective Date, (A) such Registration Statement ceases for any reason (including without limitation by reason of a stop order, or the Company's failure to update the Registration Statement), to remain continuously effective as to all Registrable Securities included in such Registration Statement or (B) the Investor is not permitted to utilize the Prospectus therein to resell such Registrable Securities for any reason for more than an aggregate of twenty (20) consecutive calendar days or forty (40) calendar days (which need not be consecutive days) during any twelve (12) month period, or (iv) the Company fails to satisfy the current public information requirement pursuant to Rule 144(c)(1) as a result of which the Investor is unable to sell Registrable Securities without restriction under Rule 144 (or any successor thereto), (any such failure or breach in clauses (i) through (iv) above being referred to as an “ Event ,” and, for purposes of clauses (i), (ii) or (iv), the date on which such Event occurs, or for purposes of clause (iii), the date on which such twenty (20) or forty (40) calendar day period is exceeded, being referred to as an “ Event Date ”), then in addition to any other rights the Investor may have hereunder or under applicable law, on each such Event Date and on each 30-day anniversary (or pro rata portion thereof) of each such Event Date (if the applicable Event shall not have been cured by such date) until the earlier of (1) the applicable Event is cured or (2) the Registrable Securities are eligible for resale pursuant to Rule 144 without manner of sale or volume restrictions, the Company shall pay to the Investor an amount in cash, as partial liquidated damages and not as a penalty (“ Liquidated Damages ”), equal (x) on the Event Date and through the fifth 30-day anniversary thereafter, one-half percent (0.5%) of the aggregate purchase price paid by the Investor

5



pursuant to the Purchase Agreement for the Convertible Notes with respect to which any unregistered Registrable Securities are then held by the Investor or would be held by the Investor if the Convertible Notes were converted, and (y) from the sixth 30-day anniversary of the Event Date and thereafter, one percent (1.0%) of the aggregate purchase price paid by the Investor pursuant to the Purchase Agreement for the Convertible Notes with respect to which any unregistered Registrable Securities are then held by the Investor or would be held by the Investor if the Convertible Notes were converted. The parties agree that (1) notwithstanding anything to the contrary herein or in the Purchase Agreement, no Liquidated Damages shall be payable with respect to any period after the expiration of the Effectiveness Period (except in respect of an Event described in Section 2(c)(iv) herein), (it being understood that this sentence shall not relieve the Company of any Liquidated Damages accruing prior to the Effectiveness Deadline) and in no event shall, the aggregate amount of Liquidated Damages (excluding Liquidated Damages payable in respect of an Event described in Section 2(c)(iv) herein) payable to the Investor exceed, in the aggregate, ten percent (10%) of the aggregate purchase price paid by the Investor pursuant to the Purchase Agreement (twelve percent (12%) if the only Event is clause (iv)) and (2) in no event shall the Company be liable in any thirty (30) day period for Liquidated Damages under this Agreement in excess of, (x) with respect to the first five 30-day anniversaries after the Event Date, and including the Event Date, one-half percent (0.5%) of the aggregate purchase price paid by the Investor pursuant to the Purchase Agreement, and (y) with respect to the sixth 30-day anniversary and any date thereafter, one percent (1.0%) of the aggregate purchase price paid by the Investor pursuant to the Purchase Agreement. If the Company fails to pay any Liquidated Damages pursuant to this Section 2(c) in full within five (5) Business Days after the date payable, the Company will pay interest thereon at a rate of one and one-half percent (1.5%) per month (or such lesser maximum amount that is permitted to be paid by applicable law) to the Investor, accruing daily from the date such Liquidated Damages are due until such amounts, plus all such interest thereon, are paid in full. The Liquidated Damages pursuant to the terms hereof shall apply on a daily pro-rata basis for any portion of a month prior to the cure of an Event. Notwithstanding the foregoing, nothing shall preclude the Investor from pursuing or obtaining any available remedies at law, specific performance or other equitable relief with respect to this Section 2(c) in accordance with applicable law. The Company shall not be liable for Liquidated Damages under this Agreement as to any Registrable Securities which are not permitted by the Commission to be included in a Registration Statement due solely to SEC Guidance from the time that it is determined that such Registrable Securities are not permitted to be registered until such time as the provisions of this Agreement as to the Remainder Registration Statements required to be filed hereunder are triggered, in which case the provisions of this Section 2(c) shall once again apply, if applicable. In such case, the Liquidated Damages shall be calculated to only apply to the percentage of Registrable Securities which are permitted in accordance with SEC Guidance to be included in such Registration Statement. The Effectiveness Deadline for a Registration Statement shall be extended without default or Liquidated Damages hereunder in the event that the Company's failure to obtain the effectiveness of the Registration Statement on a timely basis results from the failure of the Investor to timely provide the Company with information requested by the Company and necessary to complete the Registration Statement in accordance with the requirements of the Securities Act (in which the Effectiveness Deadline would be extended with respect to the Registrable Securities).

(d) The Investor agrees to furnish to the Company a completed Selling Stockholder Questionnaire not more than ten (10) Trading Days following the date of this Agreement. At least ten (10) Trading Days prior to the first anticipated filing date of a Registration Statement for any registration under this Agreement, the Company will notify the Investor of the information the Company requires from the Investor other than the information contained in the Selling Stockholder Questionnaire, if any, which shall be completed and delivered to the Company promptly upon request and, in any event, within three (3) Trading Days prior to the applicable anticipated filing date. The Investor further agrees that it shall not be entitled to be named as a selling securityholder in the Registration Statement or use the Prospectus for offers and resales of Registrable Securities at any time, unless the Investor has returned to

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the Company a completed and signed Selling Stockholder Questionnaire and a response to any requests for further information as described in the previous sentence. If the Investor returns a Selling Stockholder Questionnaire or a request for further information, in either case, after its respective deadline, the Company shall use its commercially reasonable efforts to take such actions as are required to name the Investor as a selling securityholder in the Registration Statement or any pre-effective or post-effective amendment thereto and to include (to the extent not theretofore included) in the Registration Statement the Registrable Securities identified in such late Selling Stockholder Questionnaire or request for further information. The Investor acknowledges and agrees that the information in the Selling Stockholder Questionnaire or request for further information as described in this Section 2(d) will be used by the Company in the preparation of the Registration Statement and hereby consents to the inclusion of such information in the Registration Statement.

(e) In the event that Form S-3 is not  available for the registration of the resale of Registrable Securities hereunder, the Company shall (i) register the resale of the Registrable Securities on Form S-1 or another appropriate form reasonably acceptable to the Investor and (ii) undertake to register the Registrable Securities on Form S-3 promptly after such form is available, provided that the Company shall maintain the effectiveness of the Registration Statement then in effect until such time as a Registration Statement on Form S-3 covering the Registrable Securities has been declared effective by the Commission.

3. Registration Procedures

In connection with the Company's registration obligations hereunder, the Company shall:
(a) Not less than five (5) Trading Days prior to the filing of each Registration Statement and not less than one (1) Trading Day prior to the filing of any related Prospectus or any amendment or supplement thereto (except for Annual Reports on Form 10-K, and Quarterly Reports on Form 10-Q and Current Reports on Form 8-K and any similar or successor reports), (i) furnish to the Investor copies of such Registration Statement, Prospectus or amendment or supplement thereto, as proposed to be filed, which documents will be subject to the review of the Investor (it being acknowledged and agreed that if the Investor does not object to or comment on the aforementioned documents within such five (5) Trading Day or one (1) Trading Day period, as the case may be, then the Investor shall be deemed to have consented to and approved the use of such documents) and (ii) use commercially reasonable efforts to cause its officers and directors, counsel and independent registered public accountants to respond to such inquiries as shall be necessary, in the reasonable opinion of respective counsel to the Investor, to conduct a reasonable investigation within the meaning of the Securities Act. The Company shall not file any Registration Statement or amendment or supplement thereto in a form to which the Investor reasonably objects in good faith, provided that, the Company is notified of such objection in writing within the five (5) Trading Day or one (1) Trading Day period described above, as applicable.

(b) (i) Prepare and file with the Commission such amendments (including post‑effective amendments) and supplements, to each Registration Statement and the Prospectus used in connection therewith as may be necessary to keep such Registration Statement continuously effective as to the applicable Registrable Securities for its Effectiveness Period; (ii) cause the related Prospectus to be amended or supplemented by any required Prospectus supplement (subject to the terms of this Agreement), and, as so supplemented or amended, to be filed pursuant to Rule 424; (iii) respond as promptly as reasonably practicable to any comments received from the Commission with respect to each Registration Statement or any amendment thereto and, as promptly as reasonably possible, provide the Investor true and complete copies of all correspondence from and to the Commission relating to such Registration Statement that pertains to the Investor as a “Selling Stockholder” but not any comments that

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would result in the disclosure to the Investor of material and non-public information concerning the Company; and (iv) comply with the provisions of the Securities Act and the Exchange Act with respect to the disposition of all Registrable Securities covered by a Registration Statement until such time as all of such Registrable Securities shall have been disposed of (subject to the terms of this Agreement) in accordance with the intended methods of disposition by the Investor thereof as set forth in such Registration Statement as so amended or in such Prospectus as so supplemented; provided, however, that in the event the Company informs the Investor in writing that it does not satisfy the conditions specified in Rule 172 and, as a result thereof, the Investor is required to deliver a Prospectus in connection with any disposition of Registrable Securities, the Company shall deliver to the Investor a copy of the Prospectus in electronic format and the Investor shall be responsible for the delivery of the Prospectus to the Persons to whom the Investor sells any of the Registrable Securities, and the Investor agrees to dispose of Registrable Securities in compliance with the “Plan of Distribution” described in the Registration Statement and otherwise in compliance with applicable federal and state securities laws. In the case of amendments and supplements to a Registration Statement which are required to be filed pursuant to this Agreement (including pursuant to this Section 3(b) ) by reason of the Company filing a report on Form 10-K, Form 10-Q or Form 8-K or any analogous report under the Exchange Act, the Company shall have incorporated such report by reference into such Registration Statement, if applicable, or shall file such amendments or supplements with the Commission on the same day on which the Exchange Act report which created the requirement for the Company to amend or supplement such Registration Statement was filed.

(c) Notify the Investor (which notice shall, pursuant to clauses (iii) through (v) hereof, be accompanied by an instruction to suspend the use of the Prospectus until the requisite changes have been made) as promptly as reasonably practicable (and, in the case of (i)(A) below, not less than one (1) Trading Day prior to such filing) and (if requested by any such Person) confirm such notice in writing no later than one (1) Trading Day following the day: (i)(A) when a Prospectus or any Prospectus supplement or post‑effective amendment to a Registration Statement is proposed to be filed; (B) when the Commission notifies the Company whether there will be a “review” of such Registration Statement and whenever the Commission comments in writing on any Registration Statement (in which case the Company shall provide to the Investor true and complete copies of all comments that pertain to the Investor as a “Selling Stockholder” or to the “Plan of Distribution” and all written responses thereto, but not information that the Company believes would constitute material and non-public information); and (C) with respect to each Registration Statement or any post‑effective amendment, when the same has become effective; (ii) of any request by the Commission or any other Federal or state governmental authority for amendments or supplements to a Registration Statement or Prospectus or for additional information that pertains to the Investor as a “Selling Stockholder” or the “Plan of Distribution”; (iii) of the issuance by the Commission or any other federal or state governmental authority of any stop order suspending the effectiveness of a Registration Statement covering any or all of the Registrable Securities or the initiation of any Proceedings for that purpose; (iv) of the receipt by the Company of any notification with respect to the suspension of the qualification or exemption from qualification of any of the Registrable Securities for sale in any jurisdiction, or the initiation or threatening of any Proceeding for such purpose; and (v) of the occurrence of any event or passage of time that makes the financial statements included in a Registration Statement ineligible for inclusion therein or any statement made in such Registration Statement or Prospectus or any document incorporated or deemed to be incorporated therein by reference untrue in any material respect or that requires any revisions to such Registration Statement, Prospectus or other documents so that, in the case of such Registration Statement or the Prospectus, as the case may be, it will not contain any untrue statement of a material fact or omit to state any material fact required to be stated therein or necessary to make the statements therein (in the case of any Prospectus, form of prospectus or supplement thereto, in light of the circumstances under which they were made), not misleading.

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(d) Use commercially reasonable efforts to avoid the issuance of, or, if issued, obtain the withdrawal of (i) any order suspending the effectiveness of a Registration Statement, or (ii) any suspension of the qualification (or exemption from qualification) of any of the Registrable Securities for sale in any jurisdiction, as soon as practicable.

(e) If requested by the Investor, furnish to the Investor, without charge, at least one conformed copy of each Registration Statement and each amendment thereto and all exhibits to the extent requested by such Person (including those previously furnished or incorporated by reference) promptly after the filing of such documents with the Commission; provided , that the Company shall have no obligation to provide any document pursuant to this clause that is available on the Commission's EDGAR system.

(f) Prior to any resale of Registrable Securities by the Investor, use its commercially reasonable efforts to register or qualify or cooperate with the Investor in connection with the registration or qualification (or exemption from the registration or qualification) of such Registrable Securities for the resale by the Investor under the securities or Blue Sky laws of such jurisdictions within the United States as the Investor reasonably requests in writing, to keep each registration or qualification (or exemption therefrom) effective during the Effectiveness Period and to do any and all other acts or things reasonably necessary to enable the disposition in such jurisdictions of the Registrable Securities covered by each Registration Statement; provided , that the Company shall not be required to qualify generally to do business in any jurisdiction where it is not then so qualified, subject the Company to any material tax in any such jurisdiction where it is not then so subject or file a general consent to service of process in any such jurisdiction.

(g) If requested by the Investor, cooperate with the Investor to facilitate the timely preparation and delivery of certificates representing Registrable Securities to be delivered to a transferee pursuant to the Registration Statement, which certificates shall be free, to the extent permitted by the Purchase Agreement and under law, of all restrictive legends, and to enable such Registrable Securities to be in such denominations and registered in such names as the Investor may reasonably request.

(h) Following the occurrence of any event contemplated by Section 3(c) , as promptly as reasonably practicable, prepare a supplement or amendment, including a post‑effective amendment, to the affected Registration Statements or a supplement to the related Prospectus or any document incorporated or deemed to be incorporated therein by reference, and file any other required document so that, as thereafter delivered, no Registration Statement nor any Prospectus will contain an untrue statement of a material fact or omit to state a material fact required to be stated therein or necessary to make the statements therein (in the case of any Prospectus, form of prospectus or supplement thereto, in light of the circumstances under which they were made), not misleading. If the Company notifies the Investor in accordance with clauses (iii) through (v) of Section 3(c) above to suspend the use of any Prospectus until the requisite changes to such Prospectus have been made, then the Investor shall suspend use of such Prospectus. The Company will use its commercially reasonable efforts to ensure that the use of the Prospectus may be resumed as promptly as is practicable. The Company shall be entitled to exercise its right under this Section 3(h) to suspend the availability of a Registration statement and Prospectus, subject to the payment of partial Liquidated Damages otherwise required pursuant to Section 2(c) , for a period not to exceed forty (40) calendar days (which need not be consecutive days) in any twelve (12) month period.

(i) The Company may require the Investor to furnish to the Company a certified statement as to (i) the number of shares of Common Stock beneficially owned by the Investor and any Affiliate thereof, (ii) any Financial Industry Regulatory Authority (“ FINRA ”) affiliations, (iii) any natural persons who have the power to vote or dispose of the common stock and (iv) any other information as

9



may be requested by the Commission, FINRA or any state securities commission. During any periods that the Company is unable to meet its obligations hereunder with respect to the registration of Registrable Securities because the Investor fails to furnish such information within three (3) Trading Days of the Company's request, any Liquidated Damages that are accruing at such time as to the Investor only shall be tolled and any Event that may otherwise occur solely because of such delay shall be suspended as to the Investor only, until such information is delivered to the Company.

(j) The Company shall cooperate with any registered broker through which the Investor proposes to resell its Registrable Securities in effecting a filing with FINRA pursuant to FINRA Rule 5110 as requested by any the Investor and the Company shall pay the filing fee required for the first such filing within two (2) Business Days of the request therefor.

4. Registration Expenses . All fees and expenses incident to the Company's performance of or compliance with its obligations under this Agreement (excluding any underwriting discounts and selling commissions and all legal fees and expenses of legal counsel for the Investor) shall be borne by the Company whether or not any Registrable Securities are sold pursuant to a Registration Statement. The fees and expenses referred to in the foregoing sentence shall include, without limitation, (i) all registration and filing fees (including, without limitation, fees and expenses (A) with respect to filings required to be made with any Trading Market on which the Common Stock is then listed for trading, (B) with respect to compliance with applicable state securities or Blue Sky laws (including, without limitation, fees and disbursements of counsel for the Company in connection with Blue Sky qualifications or exemptions of the Registrable Securities and determination of the eligibility of the Registrable Securities for investment under the laws of such jurisdictions as requested by the Investor) and (C) if not previously paid by the Company in connection with Section 3(j) above, with respect to any filing that may be required to be made by any broker through which the Investor intends to make sales of Registrable Securities with FINRA pursuant to the FINRA Rule 5110, so long as the broker is receiving no more than a customary brokerage commission in connection with such sale, (ii) printing expenses (including, without limitation, expenses of printing certificates for Registrable Securities and of printing prospectuses if the printing of prospectuses is reasonably requested by the Investor), (iii) messenger, telephone and delivery expenses, (iv) fees and disbursements of counsel for the Company, (v) Securities Act liability insurance, if the Company so desires such insurance, and (vi) fees and expenses of all other Persons retained by the Company in connection with the consummation of the transactions contemplated by this Agreement. In addition, the Company shall be responsible for all of its internal expenses incurred in connection with the consummation of the transactions contemplated by this Agreement (including, without limitation, all salaries and expenses of its officers and employees performing legal or accounting duties), the expense of any annual audit and the fees and expenses incurred in connection with the listing of the Registrable Securities on any securities exchange as required hereunder. In no event shall the Company be responsible for any underwriting, broker or similar fees or commissions of the Investor or, except to the extent provided for in the Purchase Agreement, any legal fees or other costs of the Investor, except as provided in the immediately succeeding sentence. The Investor shall have the right to select one legal counsel to review and oversee any registration pursuant to this Agreement (“ Legal Counsel ”) which shall be Wilson Sonsini Goodrich & Rosati, P.C. or such other counsel designated by the Investor, and the cost thereof shall be borne by the Company.

5. Indemnification .

(a) Indemnification by the Company . The Company shall, notwithstanding any termination of this Agreement, indemnify, defend and hold harmless the Investor, the officers, directors, agents, partners, members, managers, stockholders, Affiliates and employees of each of them, each Person who controls the Investor (within the meaning of Section 15 of the Securities Act or Section 20 of the Exchange Act) and the officers, directors, partners, members, managers, stockholders, agents and

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employees of each such controlling Person, to the fullest extent permitted by applicable law, from and against any and all losses, claims, damages, liabilities, costs (including, without limitation, reasonable costs of preparation and investigation and reasonable attorneys' fees) and expenses (collectively, “ Losses ”), as incurred, that arise out of or are based upon (i) any untrue or alleged untrue statement of a material fact contained in any Registration Statement, any Prospectus or any form of prospectus or in any amendment or supplement thereto or in any preliminary prospectus, or arising out of or relating to any omission or alleged omission to state a material fact required to be stated therein or necessary to make the statements therein (in the case of any Prospectus or form of prospectus or supplement thereto, in light of the circumstances under which they were made) not misleading, or (ii) any violation or alleged violation by the Company of the Securities Act, Exchange Act or any state securities law or any rule or regulation thereunder, in connection with the performance of its obligations under this Agreement, except to the extent, but only to the extent, that (A) such untrue statements, alleged untrue statements, omissions or alleged omissions are based solely upon information regarding the Investor furnished in writing to the Company by the Investor expressly for use therein, or to the extent that such information relates to the Investor or the Investor's proposed method of distribution of Registrable Securities and was reviewed and approved in writing by the Investor expressly for use in the Registration Statement, such Prospectus or such form of Prospectus or in any amendment or supplement thereto (it being understood that the Investor has approved Annex A hereto for this purpose) or (B) in the case of an occurrence of an event of the type specified in Section 3(c)(iii) - (v) , related to the use by the Investor of an outdated or defective Prospectus after the Company has notified the Investor in writing that the Prospectus is outdated or defective and prior to the receipt by the Investor of the Advice contemplated and defined in Section 6(c) below, to the extent that following the receipt of the Advice the misstatement or omission giving rise to such Loss would have been corrected or (C) to the extent that any such Losses arise out of the Investor's (or any other indemnified Person's) failure to send or give a copy of the Prospectus or supplement (as then amended or supplemented), if required, pursuant to Rule 172 under the Securities Act (or any successor rule) to the Persons asserting an untrue statement or alleged untrue statement or alleged untrue statement or omission or alleged omission at or prior to the written confirmation of the sale of Registrable Securities to such Person if such statement or omission was corrected in such Prospectus or supplement. The Company shall notify the Investor promptly of the institution, threat or assertion of any Proceeding arising from or in connection with the transactions contemplated by this Agreement of which the Company is aware. Such indemnity shall remain in full force and effect regardless of any investigation made by or on behalf of an Indemnified Party (as defined in Section 5(c) ) and shall survive the transfer of the Registrable Securities by the Investor.

(b) Indemnification by the Investor . The Investor shall, severally and not jointly, indemnify and hold harmless the Company, its directors, officers, agents and employees, each Person who controls the Company (within the meaning of Section 15 of the Securities Act and Section 20 of the Exchange Act), and the directors, officers, agents or employees of such controlling Persons, to the fullest extent permitted by applicable law, from and against all Losses, as incurred, arising out of or are based solely upon any untrue or alleged untrue statement of a material fact contained in any Registration Statement, any Prospectus, or any form of prospectus, or in any amendment or supplement thereto or in any preliminary prospectus, or arising out of or relating to any omission or alleged omission of a material fact required to be stated therein or necessary to make the statements therein (in the case of any Prospectus, or any form of prospectus or supplement thereto, in light of the circumstances under which they were made) not misleading (i) to the extent that such untrue statements or omissions are based solely upon information regarding the Investor furnished in writing to the Company by the Investor expressly for use therein or (ii) to the extent that such information relates to the Investor or the Investor's proposed method of distribution of Registrable Securities and was reviewed and approved in writing by the Investor expressly for use in a Registration Statement (it being understood that the Investor has approved Annex A hereto for this purpose), such Prospectus or such form of Prospectus or in any amendment or supplement thereto or (iii) in the case of an occurrence of an event of the type specified in Section 3(c)(iii) - (vi) , to the

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extent related to the use by the Investor of an outdated or defective Prospectus after the Company has notified the Investor in writing that the Prospectus is outdated or defective and prior to the receipt by the Investor of the Advice contemplated in Section 6(c) . In no event shall the liability of the Investor hereunder be greater in amount than the dollar amount of the net proceeds received by the Investor upon the sale of the Registrable Securities giving rise to such indemnification obligation.

(c) Conduct of Indemnification Proceedings . If any Proceeding shall be brought or asserted against any Person entitled to indemnity hereunder (an “ Indemnified Party ”), such Indemnified Party shall promptly notify the Person from whom indemnity is sought (the “ Indemnifying Party ”) in writing, and the Indemnifying Party shall have the right to assume the defense thereof, including the employment of counsel reasonably satisfactory to the Indemnified Party and the payment of all reasonable fees and expenses incurred in connection with defense thereof; provided , that the failure of any Indemnified Party to give such notice shall not relieve the Indemnifying Party of its obligations or liabilities pursuant to this Agreement, except (and only) to the extent that it shall be finally determined by a court of competent jurisdiction (which determination is not subject to appeal or further review) that such failure shall have materially and adversely prejudiced the Indemnifying Party.

An Indemnified Party shall have the right to employ separate counsel in any such Proceeding and to participate in the defense thereof, but the fees and expenses of such counsel shall be at the expense of such Indemnified Party or Parties unless: (1) the Indemnifying Party has agreed in writing to pay such fees and expenses; (2) the Indemnifying Party shall have failed promptly to assume the defense of such Proceeding and to employ counsel reasonably satisfactory to such Indemnified Party in any such Proceeding; or (3) the named parties to any such Proceeding (including any impleaded parties) include both such Indemnified Party and the Indemnifying Party, and such Indemnified Party shall have been advised by counsel that a conflict of interest exists if the same counsel were to represent such Indemnified Party and the Indemnifying Party (in which case, if such Indemnified Party notifies the Indemnifying Party in writing that it elects to employ separate counsel at the expense of the Indemnifying Party, the Indemnifying Party shall not have the right to assume the defense thereof and such counsel shall be at the expense of the Indemnifying Party); provided , that the Indemnifying Party shall not be liable for the fees and expenses of more than one separate firm of attorneys at any time for all Indemnified Parties. The Indemnifying Party shall not be liable for any settlement of any such Proceeding effected without its written consent, which consent shall not be unreasonably withheld, delayed or conditioned. No Indemnifying Party shall, without the prior written consent of the Indemnified Party, effect any settlement of any pending Proceeding in respect of which any Indemnified Party is a party, unless such settlement includes an unconditional release of such Indemnified Party from all liability on claims that are the subject matter of such Proceeding and such settlement does not include any non-monetary limitation on the actions of any Indemnified Party or any of its affiliates or any admission of fault or liability on behalf of any such Indemnified Party.
Subject to the terms of this Agreement, all fees and expenses of the Indemnified Party (including reasonable fees and expenses to the extent incurred in connection with investigating or preparing to defend such Proceeding in a manner not inconsistent with this Section 5 ) shall be paid to the Indemnified Party, as incurred, within twenty (20) Trading Days of written notice thereof to the Indemnifying Party; provided , that the Indemnified Party shall promptly reimburse the Indemnifying Party for that portion of such fees and expenses applicable to such actions for which such Indemnified Party is finally judicially determined to not be entitled to indemnification hereunder). The failure to deliver written notice to the Indemnifying Party within a reasonable time of the commencement of any such action shall not relieve such Indemnifying Party of any liability to the Indemnified Party under this Section 5 , except to the extent that the Indemnifying Party is materially and adversely prejudiced in its ability to defend such action.


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(d) Contribution . If a claim for indemnification under Section 5(a) or 5(b) is unavailable to an Indemnified Party or insufficient to hold an Indemnified Party harmless for any Losses, then each Indemnifying Party, in lieu of indemnifying such Indemnified Party, shall contribute to the amount paid or payable by such Indemnified Party as a result of such Losses, in such proportion as is appropriate to reflect the relative fault of the Indemnifying Party and Indemnified Party in connection with the actions, statements or omissions that resulted in such Losses as well as any other relevant equitable considerations. The relative fault of such Indemnifying Party and Indemnified Party shall be determined by reference to, among other things, whether any action in question, including any untrue or alleged untrue statement of a material fact or omission or alleged omission of a material fact, has been taken or made by, or relates to information supplied by, such Indemnifying Party or Indemnified Party, and the parties' relative intent, knowledge, access to information and opportunity to correct or prevent such action, statement or omission. The amount paid or payable by a party as a result of any Losses shall be deemed to include, subject to the limitations set forth in this Agreement, any reasonable attorneys' or other reasonable fees or expenses incurred by such party in connection with any Proceeding to the extent such party would have been indemnified for such fees or expenses if the indemnification provided for in this Section 5 was available to such party in accordance with its terms.

The parties hereto agree that it would not be just and equitable if contribution pursuant to this Section 5(d) were determined by pro rata allocation or by any other method of allocation that does not take into account the equitable considerations referred to in the immediately preceding paragraph. Notwithstanding the provisions of this Section 5(d) , (A) the Investor shall not be required to contribute, in the aggregate, any amount in excess of the amount by which the net proceeds actually received by the Investor from the sale of the Registrable Securities subject to the Proceeding exceeds the amount of any damages that the Investor has otherwise been required to pay by reason of such untrue or alleged untrue statement or omission or alleged omission and (B) no contribution will be made under circumstances where the maker of such contribution would not have been required to indemnify the Indemnified Party under the fault standards set forth in this Section 5 . No person guilty of fraudulent misrepresentation (within the meaning of Section 11(f) of the Securities Act) shall be entitled to contribution from any Person who was not guilty of such fraudulent misrepresentation.
The indemnity and contribution agreements contained in this Section 5 are in addition to any liability that the Indemnifying Parties may have to the Indemnified Parties and are not in diminution or limitation of the indemnification provisions under the Purchase Agreement.
6. Miscellaneous .

(a) Remedies . In the event of a breach by the Company or by the Investor of any of their obligations under this Agreement, the Investor or the Company, as the case may be, in addition to being entitled to exercise all rights granted by law and under this Agreement, including recovery of damages, will be entitled to specific performance of its rights under this Agreement. The Company and the Investor agree that monetary damages would not provide adequate compensation for any losses incurred by reason of a breach by it of any of the provisions of this Agreement and hereby further agrees that, in the event of any action for specific performance in respect of such breach, it shall waive the defense that a remedy at law would be adequate.

(b) Compliance . The Investor covenants and agrees that in the event the Company informs the Investor in writing that it does not satisfy the conditions specified in Rule 172 and, as a result thereof, the Investor is required to deliver a Prospectus in connection with any disposition of Registrable Securities, it will comply with the prospectus delivery requirements of the Securities Act as applicable to it (unless an exemption therefrom is available) in connection with sales of Registrable Securities pursuant

13



to the Registration Statement and shall sell the Registrable Securities only in accordance with a method of distribution described in the Registration Statement

(c) Discontinued Disposition . By its acquisition of Registrable Securities, the Investor agrees that, upon receipt of a notice from the Company of the occurrence of any event of the kind described in Section 3(c)(iii) - (v) , the Investor will forthwith discontinue disposition of such Registrable Securities under a Registration Statement until it is advised in writing (the “ Advice ”) by the Company that the use of the applicable Prospectus (as it may have been supplemented or amended) may be resumed. The Company will use its commercially reasonable efforts to ensure that the use of the Prospectus may be resumed as promptly as is practicable. The Company agrees and acknowledges that any periods during which the Investor is required to discontinue the disposition of the Registrable Securities hereunder shall be subject to the provisions of Section 2(c) .

(d) No Inconsistent Agreements . Neither the Company nor any of its Subsidiaries has entered, as of the date hereof, nor shall the Company or any of its Subsidiaries, on or after the date hereof, enter into any agreement with respect to its securities, that would have the effect of impairing the rights granted to the Investor in this Agreement or otherwise conflicts with the provisions hereof.

(e) Amendments and Waivers . The provisions of this Agreement, including the provisions of this sentence, may not be amended, modified or supplemented, or waived unless the same shall be in writing and signed by the Company and the Investor.

(f) Notices . Any and all notices or other communications or deliveries required or permitted to be provided hereunder shall be delivered as set forth in the Purchase Agreement.

(g) Successors and Assigns . This Agreement shall inure to the benefit of and be binding upon the successors and permitted assigns of each of the parties hereto. Nothing in this Agreement, express or implied, is intended to confer upon any party other than the parties hereto or their respective successors and assigns any rights, remedies, obligations, or liabilities under or by reason of this Agreement, except as expressly provided in this Agreement. The Company may not assign its rights (except by merger or in connection with another entity acquiring all or substantially all of the Company's assets) or obligations hereunder without the prior written consent the Investor. The Investor may assign its rights hereunder to Permitted Transferees (as defined in the Purchase Agreement) in the manner provided in the Purchase Agreement, provided in each case that (i) the Investor agrees in writing with the Permitted Transferee to assign such rights and related obligations under this Agreement, and for the Permitted Transferee to assume such obligations, and a copy of such agreement is furnished to the Company within a reasonable time after such assignment, (ii) the Company is, within a reasonable time after such transfer or assignment, furnished with written notice of the name and address of such Permitted Transferee and the securities with respect to which such registration rights are being transferred or assigned, (iii) at or before the time the Company received the written notice contemplated by clause (ii) of this sentence, the Permitted Transferee agrees in writing with the Company to be bound by all of the provisions contained herein and (iv) the Permitted Transferee is an “accredited investor,” as that term is defined in Rule 501 of Regulation D.

(h) Execution and Counterparts . This Agreement may be executed in two or more counterparts, each of which when so executed shall be deemed to be an original and, all of which taken together shall constitute one and the same Agreement and shall become effective when counterparts have been signed by each party and delivered to the other party, it being understood that both parties need not sign the same counterpart. In the event that any signature is delivered by facsimile transmission or by e-mail delivery of a “.pdf” format data file, such signature shall create a valid and binding obligation of the

14



party executing (or on whose behalf such signature is executed) with the same force and effect as if such facsimile or “.pdf” signature were the original thereof.

(i) Governing Law . All questions concerning the construction, validity, enforcement and interpretation of this Agreement shall be determined in accordance with the provisions of the Purchase Agreement.

(j) Cumulative Remedies . The remedies provided herein are cumulative and not exclusive of any other remedies provided by law.

(k) Severability . If any term, provision, covenant or restriction of this Agreement is held by a court of competent jurisdiction to be invalid, illegal, void or unenforceable, the remainder of the terms, provisions, covenants and restrictions set forth herein shall remain in full force and effect and shall in no way be affected, impaired or invalidated, and the parties hereto shall use their good faith reasonable efforts to find and employ an alternative means to achieve the same or substantially the same result as that contemplated by such term, provision, covenant or restriction. It is hereby stipulated and declared to be the intention of the parties that they would have executed the remaining terms, provisions, covenants and restrictions without including any of such that may be hereafter declared invalid, illegal, void or unenforceable.

(l) Headings . The headings in this Agreement are for convenience only and shall not limit or otherwise affect the meaning hereof.

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15



IN WITNESS WHEREOF, the parties have executed this Registration Rights Agreement as of the date first written above.
AMYRIS, INC.


By: /s/ John Melo                
Name: John Melo
Title: President and Chief Executive Officer
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16



IN WITNESS WHEREOF, the parties have executed this Registration Rights Agreement as of the date first written above.

INVESTOR
TOTAL GAS & POWER USA, SAS

By: Bernard Clément        
Name: Bernard Clément
Title: Authorized Signatory



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17



Annex A
PLAN OF DISTRIBUTION

We are registering the shares of common stock previously issued to the selling stockholder and issuable upon conversion of the Convertible Notes previously issued to the selling stockholder to permit the resale of these shares of common stock by the holder of the common stock and Convertible Notes from time to time after the date of this prospectus. We will not receive any of the proceeds from the sale by the selling stockholder of the shares of common stock. We will bear all fees and expenses incident to our obligation to register the shares of common stock.
The selling stockholder may sell all or a portion of the shares of common stock beneficially owned by it and offered hereby from time to time directly or through one or more underwriters, broker-dealers or agents. If the shares of common stock are sold through underwriters or broker-dealers, the selling stockholder will be responsible for underwriting discounts or commissions or agent's commissions. The shares of common stock may be sold in one or more transactions at fixed prices, at prevailing market prices at the time of the sale, at varying prices determined at the time of sale, or at negotiated prices. The selling stockholder will act independently of us in making decisions with respect to the timing, manner and size of each sale. These sales may be effected in transactions, which may involve crosses or block transactions,
on any national securities exchange or quotation service on which the securities may be listed or quoted at the time of sale;

in the over-the-counter market;

in transactions otherwise than on these exchanges or systems or in the over-the-counter market;

through the writing of options, whether such options are listed on an options exchange or otherwise;

ordinary brokerage transactions and transactions in which the broker-dealer solicits purchasers;

block trades in which the broker-dealer will attempt to sell the shares as agent but may position and resell a portion of the block as principal to facilitate the transaction;

purchases by a broker-dealer as principal and resale by the broker-dealer for its account;

an exchange distribution in accordance with the rules of the applicable exchange;

privately negotiated transactions;

short sales;

through the distribution of the common stock by the selling stockholder to its partners, members or stockholders;





through one or more underwritten offerings on a firm commitment or best efforts basis;

sales pursuant to Rule 144;

broker-dealers may agree with the selling stockholder to sell a specified number of such shares at a stipulated price per share;

a combination of any such methods of sale; and

any other method permitted pursuant to applicable law.

If the selling stockholder effects such transactions by selling shares of common stock to or through underwriters, broker-dealers or agents, such underwriters, broker-dealers or agents may receive commissions in the form of discounts, concessions or commissions from the selling stockholder or commissions from purchasers of the shares of common stock for whom they may act as agent or to whom they may sell as principal (which discounts, concessions or commissions as to particular underwriters, broker-dealers or agents may be in excess of those customary in the types of transactions involved). In connection with sales of the shares of common stock or otherwise, the selling stockholder may enter into hedging transactions with broker-dealers, which may in turn engage in short sales of the shares of common stock in the course of hedging in positions they assume. The selling stockholder may also sell shares of common stock short and deliver shares of common stock covered by this prospectus to close out short positions and to return borrowed shares in connection with such short sales. The selling stockholder may also loan or pledge shares of common stock to broker-dealers that in turn may sell such shares.
The selling stockholder may pledge or grant a security interest in some or all of the shares of common stock owned by it and, if it defaults in the performance of its secured obligations, the pledgees or secured parties may offer and sell the shares of common stock from time to time pursuant to this prospectus or any amendment to this prospectus under Rule 424(b)(3) or other applicable provision of the Securities Act amending, if necessary, the list of selling stockholder to include the pledgee, transferee or other successors in interest as selling stockholder under this prospectus. The selling stockholder also may transfer and donate the shares of common stock in other circumstances in which case the transferees, donees, pledgees or other successors in interest will be the selling beneficial owners for purposes of this prospectus.
The selling stockholder and any broker-dealer participating in the distribution of the shares of common stock may be deemed to be “underwriters” within the meaning of the Securities Act, and any commission paid, or any discounts or concessions allowed to, any such broker-dealer may be deemed to be underwriting commissions or discounts under the Securities Act. At the time a particular offering of the shares of common stock is made, a prospectus supplement, if required, will be distributed which will set forth the aggregate amount of shares of common stock being offered and the terms of the offering, including the name or names of any broker-dealers or agents, any discounts, commissions and other terms constituting compensation from the selling stockholder and any discounts, commissions or concessions allowed or reallowed or paid to broker-dealers. The selling stockholder may indemnify any broker-dealer that participates in transactions involving the sale of the shares of common stock against certain liabilities, including liabilities arising under the Securities Act.
Under the securities laws of some states, the shares of common stock may be sold in such states only through registered or licensed brokers or dealers. In addition, in some states the shares of common stock may not be sold unless such shares have been registered or qualified for sale in such state or an exemption from registration or qualification is available and is complied with.




There can be no assurance that any selling stockholder will sell any or all of the shares of common stock registered pursuant to the registration statement, of which this prospectus forms a part.
The selling stockholder and any other person participating in such distribution will be subject to applicable provisions of the Exchange Act and the rules and regulations thereunder, including, without limitation, Regulation M of the Exchange Act, which may limit the timing of purchases and sales of any of the shares of common stock by the selling stockholder and any other participating person. Regulation M may also restrict the ability of any person engaged in the distribution of the shares of common stock to engage in market-making activities with respect to the shares of common stock. All of the foregoing may affect the marketability of the shares of common stock and the ability of any person or entity to engage in market-making activities with respect to the shares of common stock.
We will pay all expenses of the registration of the shares of common stock pursuant to the registration rights agreement, estimated to be $______ in total, including, without limitation, SEC filing fees and expenses of compliance with state securities or “Blue Sky” laws; provided , however , that a selling stockholder will pay all underwriting discounts and selling commissions, if any. We will indemnify the selling stockholder against liabilities, including some liabilities under the Securities Act, in accordance with the registration rights agreement, or the selling stockholder will be entitled to contribution. We may be indemnified by the selling stockholder against civil liabilities, including liabilities under the Securities Act, that may arise from any written information furnished to us by the selling stockholder specifically for use in this prospectus, in accordance with the registration rights agreement, or we may be entitled to contribution.
Once sold under the registration statement, of which this prospectus forms a part, the shares of common stock will be freely tradable in the hands of persons other than our affiliates.




Annex B
AMYRIS, INC.

SELLING STOCKHOLDER NOTICE AND QUESTIONNAIRE


The undersigned holder of shares of the common stock, par value $0.01 per share, of Amyris, Inc. (the “ Company ”) understands that the Company intends to file with the Securities and Exchange Commission a registration statement on Form S-3 (the “ Resale Registration Statemen t”) for the registration and the resale under Rule 415 of the Securities Act of 1933, as amended (the “ Securities Act ”), of the Registrable Securities in accordance with the terms of the Registration Rights Agreement. All capitalized terms not otherwise defined herein shall have the meanings ascribed thereto in the Registration Rights Agreement.

In order to sell or otherwise dispose of any Registrable Securities pursuant to the Resale Registration Statement, the undersigned holder of Registrable Securities will be required to be named as a selling stockholder in the related prospectus or a supplement thereto (as so supplemented, the “ Prospectus ”), deliver the Prospectus to purchasers of Registrable Securities (including pursuant to Rule 172 under the Securities Act) and be bound by the provisions of the Registration Rights Agreement (including certain indemnification provisions, as described below). The undersigned holder must complete and deliver this Notice and Questionnaire in order to be named as a selling stockholder in the Prospectus.

Certain legal consequences arise from being named as a selling stockholder in the Resale Registration Statement and the Prospectus. The undersigned holder of Registrable Securities is advised to consult its own securities law counsel regarding the consequences of being named or not named as a selling stockholder in the Resale Registration Statement and the Prospectus.

NOTICE

The undersigned holder (the “ Selling Stockholder ”) of Registrable Securities hereby gives notice to the Company of its intention to sell or otherwise dispose of Registrable Securities owned by it and listed below in Item (3), unless otherwise specified in Item (3), pursuant to the Resale Registration Statement. The undersigned, by signing and returning this Notice and Questionnaire, understands and agrees that it will be bound by the terms and conditions of this Notice and Questionnaire and the Registration Rights Agreement.

The undersigned hereby provides the following information to the Company and represents that such information is accurate and complete:

QUESTIONNAIRE

1.
Name .

(a)
Full Legal Name of Selling Stockholder:
____________________________
(b)
Full Legal Name of Registered Holder (if not the same as (a) above) through which Registrable Securities Listed in Item 3 below are held:
____________________________





(c)
Full Legal Name of Natural Control Person (which means a natural person who directly or indirectly alone or with others has power to vote or dispose of the securities covered by the questionnaire):
____________________________

2.
Address for Notices to Selling Stockholder:
 
 
 
Telephone:
Fax:
Contact Person:
E-mail address of Contact Person:

3.
Beneficial Ownership of Registrable Securities:

(a)
Type and Number of Registrable Securities beneficially owned:
____________________________
____________________________
____________________________
(b)
Number of shares of Common Stock to be registered pursuant to this Notice for resale:
____________________________
____________________________
____________________________
4.
Broker-Dealer Status:

(a)
Are you a broker-dealer?

Yes     No
(b)
If “yes” to Section 4(a), did you receive your Registrable Securities as compensation for investment banking services to the Company?

Yes     No
Note:
If no, the Commission's staff has indicated that you should be identified as an underwriter in the Registration Statement.
(c)
Are you an affiliate of a broker-dealer?

Yes     No
Note:    If yes, provide a narrative explanation below:




____________________________
____________________________
(d)
If you are an affiliate of a broker-dealer, do you certify that you bought the Registrable Securities in the ordinary course of business, and at the time of the purchase of the Registrable Securities to be resold, you had no agreements or understandings, directly or indirectly, with any person to distribute the Registrable Securities?
Yes     No
Note:
If no, the Commission's staff has indicated that you should be identified as an underwriter in the Registration Statement.
5.
Beneficial Ownership of Other Securities of the Company Owned by the Selling Stockholder .

Except as set forth below in this Item 5, the undersigned is not the beneficial or registered owner of any securities of the Company other than the Registrable Securities listed above in Item 3.
Type and amount of other securities beneficially owned:
________________________________________________________________________________________________________________________________________________
________________________________________________________________________________________________________________________________________________
6.
Relationships with the Company:

Except as set forth below, neither the undersigned nor any of its affiliates, officers, directors or principal equity holders (owners of 5% of more of the equity securities of the undersigned) has held any position or office or has had any other material relationship with the Company (or its predecessors or affiliates) during the past three years.
State any exceptions here:
____________________________________________________________________________________________________________________________________________________________
____________________________________________________________________________________________________________________________________________________________
7.
Plan of Distribution:

The undersigned has reviewed the form of Plan of Distribution attached as Annex A to the Registration Rights Agreement, and hereby confirms that, except as set forth below, the information contained therein regarding the undersigned and its plan of distribution is correct and complete.
State any exceptions here:
__________________________________________________________________________________________________________________________________________________________
__________________________________________________________________________________________________________________________________________________________
***********




The undersigned agrees to promptly notify the Company of any inaccuracies or changes in the information provided herein that may occur subsequent to the date hereof and prior to the effective date of any applicable Resale Registration Statement. All notices hereunder and pursuant to the Registration Rights Agreement shall be made in writing, by hand delivery, confirmed or facsimile transmission, first-class mail or air courier guaranteeing overnight delivery at the address set forth below. In the absence of any such notification, the Company shall be entitled to continue to rely on the accuracy of the information in this Notice and Questionnaire.
By signing below, the undersigned consents to the disclosure of the information contained herein in its answers to Items (1) through (7) above and the inclusion of such information in the Resale Registration Statement and the Prospectus. The undersigned understands that such information will be relied upon by the Company in connection with the preparation or amendment of any such Registration Statement and the Prospectus.
By signing below, the undersigned acknowledges that it understands its obligation to comply, and agrees that it will comply, with the provisions of the Exchange Act and the rules and regulations thereunder, particularly Regulation M in connection with any offering of Registrable Securities pursuant to the Resale Registration Statement. The undersigned also acknowledges that it understands that the answers to this Questionnaire are furnished for use in connection with Registration Statements filed pursuant to the Registration Rights Agreement and any amendments or supplements thereto filed with the Commission pursuant to the Securities Act.
By returning this Questionnaire, the undersigned will be deemed to be aware of the foregoing interpretation.
I confirm that, to the best of my knowledge and belief, the foregoing statements (including, without limitation the answers to this Questionnaire) are correct.
IN WITNESS WHEREOF the undersigned, by authority duly given, has caused this Questionnaire to be executed and delivered either in person or by its duly authorized agent.
Dated:          Beneficial Owner:     
By:     
Name:
Title:








CONFIDENTIAL TREATMENT REQUESTED. CERTAIN PORTIONS OF THIS DOCUMENT HAVE BEEN OMITTED PURSUANT TO A REQUEST FOR CONFIDENTIAL TREATMENT AND, WHERE APPLICABLE, HAVE BEEN MARKED WITH AN ASTERISK TO DENOTE WHERE OMISSIONS HAVE BEEN MADE. THE CONFIDENTIAL MATERIAL HAS BEEN FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION.


BANK CREDIT NOTE
TABLE I - INFORMATION ON THE NOTE
Number of the Note
2766
Maturity Date
July 15, 2022
Amount of the Note
R$30,000,000.00
Type of Credit
BNDES FINAME - PSI
PAC Number
66.716-1
PAC Approved on
July 12, 2012
City of Payment
São Paulo - State of São Paulo
TABLE II - LENDER
NOSSA CAIXA DESENVOLVIMENTO - AGÊNCIA DE FOMENTO DO ESTADO DE SÃO PAULO S.A. , with its principal place of business in the Capital City of the State of São Paulo, at Rua da Consolação, 371 - Consolação, enrolled with the CNPJ/MF under No. 10.663.610/0001-29.
BNDES Authorization

521-5
TABLE III - ISSUER
Corporate Name
AMYRIS BRASIL LTDA
CNPJ/MF
09.379.224/0001-20
Address
R James Clerk Maxwell, 315
District
Techno Park
City
Campinas
State
 São Paulo
Postal Code
13.069-380
Checking Account No.
07494-1
Branch
4009
Bank
341
TABLE IV - PURPOSE OF THE LOAN AND PROPERTY SELLER
The Loan agreed under this Bank Credit Note shall be used for acquisition of the property described below, for the construction of an industrial plant for the Farnesene Production System at Paraíso plant, in the City of Brotas, State of São Paulo.
Description of the Financed Property
Units
1
Model
FARNESENE PRODUCTION SYSTEM, MOD. PEBR 10106
Product Code/FINAME
2887533
Price of the Property
R$82,410,000.00
Seller
Corporate Name
GEA ENGENHARIA DE PROCESSOS E SISTEMAS INDUSTRIAIS LTDA
CNPJ/MF
49.070.824/0001-27
Address
AV. Mercedes Benz, 679 - BUILDING 4D2 FLOOR 1 P
District
Distrito Industrial
City
Campinas
State
São Paulo
Postal Code
13.054-750
Checking Account No.
41595-0
Branch
1370
Bank
341
TABLE V - CHARACTERISTICS OF THE TRANSACTION

1



Total Price of the Financed Project
R$52,000,000.00
Amount of the Loan
R$30,000,000.00
TCC Amount
R$20,000.00
Amortization Period
96 months
Grace Period
24 months
Financial Burden
Nominal Interest Rate
0.4472% per month
Nominal Interest Rate

5.37% per year
Actual Interest Rate

5.5% per year
CET

5.58% per year
Delinquency Charges
Permanence Commission
8.9% per month
Interest for Late Payment
1% per month
TABLE VI - GUARANTEES
6.1. CORPORATE GUARANTEE
Name/Corporate Name of the Surety
Amyris Inc.
CNPJ/MF
09.345.642/0001-05
Address
5885 Hollis Street, Suite 100 - Emeryville, CA 94608 - United States of America
Legal Representative(s)
João Gabriel Alves de Melo
Identification Document
Passport: [*]
Nationality
Portuguese
Title
CEO and President
6.2. FIDUCIARY SALE OF PERSONAL PROPERTY
Pursuant to the “Instrument of Fiduciary Sale of Personal Property”, which is an integral part of this Bank Credit Note.
CONDITIONS APPLICABLE TO THE BANK CREDIT NOTE
I - OFFER OF PAYMENT
1.1. ISSUER and the other codebtors offer to pay by this Bank Credit Note (Note or CCB), in favor of NOSSA CAIXA DESENVOLVIMENTO - AGÊNCIA DE FOMENTO DO ESTADO DE SÃO PAULO S.A. (São Paulo State Development Agency or LENDER), or to its order, at the “City of Payment” and on the “Maturity” date set forth in TABLE I, the amount set forth in the Field “Amount of the Note”, which corresponds to the “Amount of the Loan”, which shall be increased by the Financial Burdens set forth in TABLE V and, should this be the case, by the statutory burdens and the Delinquency Charges contemplated herein, representing a net, certain and payable obligation to pay such amount in cash, pursuant to the provisions of article 29, item II of Law No. 10.931/2004.
II - RELEASE OF THE LOAN
2.1. Pursuant to the applicable statutory provisions, the São Paulo State Development Agency grants ISSUER , within the scope of the BNDES Investment Maintenance Program ( BNDES-PSI ), the credit approved by Agência Especial de Financiamento Industrial - FINAME , a state-owned company created by Law No. 5662, of June 21, 1971, as agent of the Brazilian Bank of Economic and Social Development - BNDES , in the amount set forth in the Field “Amount of the Loan” mentioned in TABLE V , which is intended for acquisition of the Property/Equipment described in TABLE IV , in accordance with the budget presented to the Consortium LEADER , as provided in sub-item 2.1.1.
2.1.1. ISSUER hereby represents that it is aware of and agrees to the fact that the loan for acquisition of the Property/Equipment described in TABLE IV is made by means of a Consortium between the Financial Agents, the São Paulo State Development Agency and BANCO PINE S.A., pursuant to the provisions of the General Conditions included in EXHIBIT VIII to BNDES Circular No. 33/2011, of September 1 st , 2011, it being understood that BANCO PINE is designated the Consortium LEADER (LEADER), as agreed by the Consortium members.
[*] Certain portions denoted with an asterisk have been omitted and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested with respect to the omitted portions.


2



2.1.2. It is hereby agreed that the São Paulo State Development Agency is exempted from any liability with respect to the dependency, availability and sufficiency of funds of the BNDES-PSI/FINAME, as required for completion of this Loan, it being understood that in the event of unavailability and/or insufficiency of funds of the BNDES, this Note shall be automatically cancelled, regardless of any judicial or extrajudicial notification, in which case ISSUER shall not be entitled to damages or redress as a result of failure to release the corresponding credit.
2.2. The funds shall be released by the São Paulo State Development Agency within up to one (1) business day as from actual release by the BNDES/FINAME or, in the event of releases in installments, the releases shall be made as set forth in the Release Schedule attached to the Credit Extension Offer (PAC) presented by the LEADER , as duly approved by the BNDES/FINAME , to which this Note is copied and which shall become an integral part hereof for all purposes and effects.
2.2.1. Release of the funds shall be further conditional upon: (i) proof of due investment of the installment previously released/used, in the event of release in installments; (ii) proof by ISSUER of the actual and regular pledge of the guarantee contemplated in subsection 6.2 of TABLE VI, as provided in the Instrument of Fiduciary Sale of Personal Property, which is an integral part hereof, granted in favor of the São Paulo State Development Agency and of BANCO PINE; (iii) inexistence of any fact that, at the discretion of the BNDES and/or of the São Paulo State Development Agency, significantly changes the economic and financial situation of ISSUER, or which may jeopardize performance of the subject matter of the loan in order to change it or to prevent performance thereof, pursuant to the provisions of the Project ratified by the BNDES/FINAME; (iv) presentation, by ISSUER, of a Debt Clearance Certificate - CND or Certificate of Suspended Debt Liability - CPD-EN, issued by the Brazilian Federal Revenue Service by the INTERNET, to be extracted by ISSUER and verified by the São Paulo State Development Agency at the addresses: www.previdenciasocial.gov.br or www.receita.fazenda.gov.br , except if such proof is waived as a result of a statutory and/or normative provision; (v) proof, should this be the case, of regular standing with respect to the environmental authorities or, if such proof has already been presented and is in effect, a statement by ISSUER in this respect; (vi) payment, should this be the case, of the expenses referred to in subsection 3.4.1.
2.3. Subject to the other conditions set forth in this Note, the funds to be released hereunder shall be directly credited to the deposit account held by SELLER, as described in TABLE IV, or to its order to ISSUER, by means of bank transfer(s) in the amount mentioned in the corresponding Field “Amount of the Loan” referred to in TABLE V, by means of presentation of the corresponding Tax document(s), in which case ISSUER irrevocably and irreversibly authorizes the São Paulo State Development Agency to adopt the procedure set forth herein, giving full and general release with respect to receipt of the amount then released.
2.3.1. The release(s) referred to in subsection 2.3 may be made by means of Wire Transfer of Immediately Available Funds (TED) , Credit Document or transfer between accounts held with the same Institution, to an account held by SELLER or by whomever SELLER indicates.
2.3.2. Whenever the amount to be released is transferred by means of Wire Transfer of Immediately Available Funds (TED) or Credit Document (DOC) , ISSUER shall be liable for reimbursement of the fee charged by the corresponding Financial Institution, plus any possible tax levied thereon, pursuant to the Third-Party Services Expenses Reimbursement Table, as disclosed on São Paulo State Development Agency's website: www.desenvolvesp.com.br ; in which case ISSUER agrees to pay such amount by means of a Bank Bill to be issued by the São Paulo State Development Agency or as otherwise defined by it.

3



III - FINANCIAL BURDEN AND OTHER LOAN EXPENSES
3.1. The Interest levied on the “Amount of the Loan” is set forth in the Field “Interest Rate” in TABLE V, and the following formula shall be adopted:
J n = SD n-1 {(1 + i /100) N/360 - 1}
J n : Interest to be paid by ISSUER , in Brazilian Reais (R$), at the time “n”;
SD n-1 : Debit Balance, in R$, at the time “n-1”;
i : five point five percent (5.5%);
N: number of days between the date of the financial event and the date of capitalization, maturity or performance of the obligation, it being understood that financial event shall be understood as any and all financial facts that result or may result in a change in the debit balance of this Note.
3.1.1. The Interest shall be payable: (i) on a quarterly basis, during the grace period; and (ii) on a monthly basis, during the amortization period, along with payment of the installments of principal, and upon maturity or payment of the Note.
3.1.2. The “Interest Rate” set forth in TABLE V already includes the remunerations due to the BNDES and to the São Paulo State Development Agency.
3.2. In the event of substitution of the legal criterion of Remuneration of the funds transferred to the BNDES from the Social Integration Program of the Public Servant Fund (PIS/PASEP) and from the Workers Support Fund - FAT, the remuneration set forth in this Note may, at the discretion of the BNDES/FINAME, be made by means of use of the new remuneration criterion applicable to said funds, or by another criterion indicated by the BNDES/FINAME itself, which, in addition to preserving the actual amount of the transaction, remunerates it in the same previous levels, in which case the São Paulo State Development Agency shall give ISSUER written notice thereof.
3.3. In case the BNDES/FINAME so requires, on the dates of release of the funds or of cancelation of the transaction, ISSUER shall pay the Credit Reserve Commission, which shall correspond to zero point one percent (0.1%) per month, to be levied on the amount of the corresponding release or of the cancelled balance, as from the date of approval of the PAC.
3.4. In addition to the charges referred to in subsection 3.1., ISSUER and the other Codebtors are required to pay: (i) all taxes or legal expenses levied or that come to be levied on this transaction, in the form and at the rates set forth in the applicable law; (ii) other statutory charges, or charges contemplated in the regulations issued by the Central Bank of Brazil (BACEN), BNDES/FINAME; (iii) of the Credit Extension Fee (TCC), in the amount set forth in TABLE V, and of the Reimbursement of the Credit Release Fee (TED and DOC), as set forth in subsection 2.3.2.
3.4.1. The amounts related to the charges set forth in subsection 3.4, should this be the case, shall be paid by ISSUER before release of the credit, it being understood that failure to make this payment shall authorize the São Paulo State Development Agency to suspend the corresponding release, without prejudice to the other penalties set forth in this Note.

4



3.5. ISSUER shall also pay to the São Paulo State Development Agency, should this be the case, fees and/or fee reimbursement, pursuant to the provisions of the “Fee Table” and/or of the “Third-Party Services Expenses Reimbursement Table” available at São Paulo State Development Agency's address: www.desenvolvesp.com.br .
3.5.1. The payments referred to in subsections 3.4.1 and 3.5 shall be made by ISSUER by means of Bank Bills issued in favor of the São Paulo State Development Agency, in any bank that participates in the Bank Clearance System, or by any other means permitted by the São Paulo State Development Agency.
3.6. Without prejudice to the other provisions of this item III, ISSUER represents, for all purposes and effects, that before formalization of the Transaction that is the subject matter hereof, it became aware and is aware of the percentage relating to the Total Actual Cost (CET) mentioned in TABLE V, as well as of the calculation flows thereof, with which it hereby agrees.
3.6.1 ISSUER is aware of and agrees to the fact that calculation of the annual CET percentage referred to in subsection 3.6 took into consideration the flows relating to the scheduled release(s) and payment(s), including the Interest Rate agreed hereunder, taxes, fees, insurance and other expenses on the Loan, in addition to those related to payment of the third-party services agreed by the São Paulo State Development Agency.
IV - DEBT PROCESSING AND COLLECTION
4.1. ISSUER and the other codebtors under this Note agree to pay the Loan, subject to the grace period, in accordance with the monthly installments and on the maturity dates mentioned in the Schedule set forth in the EXHIBIT - PAYMENT SCHEDULE, which, after read and initialed by the parties, shall be an integral part of this Note for all purposes and effects.
4.1.1. Subject to the provisions of the corresponding Field of TABLE V, the grace period shall start on the fifteenth (15 th ) day of the month, after the date of issuance/execution hereof.
4.1.2. During the grace period, ISSUER and the other codebtors agree to quarterly pay the Interest accrued in the period, in accordance with the criteria set forth in this Note, which term shall commence on the date referred to in subsection 4.1.1.
4.1.3. During the term of amortization, ISSUER and the other codebtors agree to pay the principal of the Loan, by means of monthly and successive installments, each of which in the unmatured amount of the principal, divided by the number of unmatured installments, plus the monthly interest set forth in this Note, it being understood that the first installment shall be due on the fifteenth (15 th ) day of the month following the end of the grace period.
4.2. Collection of the principal and charges shall be made by means of a Bank Bill, which shall have the same effects as a Collection Notice, and which shall be sent by the São Paulo State Development Agency to ISSUER and contain the required amount for payment of the corresponding installment on the maturity date, to be paid in any bank that participates in the Bank Clearance System.
4.2.1. The provisions of subsection 4.2 does not exempt ISSUER and the other codebtors from the obligation to timely pay the installments of the Loan on the dates set forth in this Note, including in case the bank bills have not been received by ISSUER, for any reason, it being understood that ISSUER shall be liable for the late payment charges set forth herein in the event of late payment.

5



4.2.2. If ISSUER and the other codebtors fail to pay the installment(s), including charges, on the agreed date(s), these installments shall be added to the debit balance of this transaction, and in the event of nonperformance and/or default, the permanence commission, interest and fine, as provided in Item V of this Note, shall apply to the unpaid amount of the debt.
4.2.3. In case any installment of the principal and/or charges is due on a Saturday, Sunday or national holiday, including bank holidays, such maturity date shall be, for all purposes and effects, transferred to the first subsequent business day, it being understood that the charges shall be calculated by such date, on which the next regular period of assessment and calculation of the transaction charges shall commence.
4.3. ISSUER may prepay the debt, except in the event BNDES has the right to refuse prepayment, it being hereby agreed that: (i) if partial prepayment is accepted, such prepayment shall be proportionally used to cover the unmatured installments of principal, maintaining the same maturity dates and adopting the same remuneration and calculation criteria set forth in this Note; (ii) if prepayment of the total amount of the debt is accepted, the same remuneration and calculation criteria set forth in this Note shall be adopted.
4.3.1. In addition, in the event of prepayment of the total amount of the debt, the other obligations to do or not to do assumed by ISSUER shall be maintained until the maturity date set forth in this Note, especially the obligation to carry out the project that is the subject matter of this Loan within the agreed term, it being understood that the São Paulo State Development Agency and the BNDES shall be entitled to inspect conduction of the project.
4.3.2. In the event of verification of irregular investment of funds during an inspection conducted pursuant to the provisions of subsection 4.3.1., ISSUER shall be subject to the penalties imposed by the BNDES and to those described in this Note.
4.3.3. In the event of nonperformance and/or default, ISSUER and the other codebtors hereby irrevocably and irreversibly authorize the São Paulo State Development Agency to offset, pursuant to the provisions of article 368 of the Brazilian Civil Code, its credit, as represented by the debit balance hereof, against any cash and cash equivalents they may own, either currently existing or that come to exist in the future, including as a result of other credit transactions possibly released to ISSUER.
V - EARLY MATURITY OF THE LOAN AND DELINQUENCY CHARGES
5.1. The early maturity of this Note shall be declared, in which case the whole debt shall become immediately payable, including the charges set forth herein, with immediate suspension of the release of any disbursement to ISSUER, should this be the case, upon occurrence of the following events: (i) failure by ISSUER to physically or financially prove conduction of the project that is the subject matter of the financial cooperation with respect to the Loan agreed hereunder; (ii) investment of the funds granted hereunder for other purposes than those set forth in TABLE IV hereof; (iii) inexistence of or failure to update or to provide the São Paulo State Development Agency and the BNDES with the records required under subsection 3.13.6 of Exhibit I to Circular No. 33/2011, as the case may be (only in the transactions with Beneficiaries engaged, among others, in the planting, renewal and costing of crops, and also the processing of sugarcane for the production of ethanol and other sugarcane-derived biofuels, and sugar, except for brown sugar, pursuant to the codes 0113-0/00, 1071-6/00, 1072-4/01 and 1931-4/00 of the National Code of Economic Activity (CNAE) disclosed by the Brazilian Institute of Geography and Statistics (IBGE); (iv) existence of an unappealable adverse judgment as a result of the practice of actions, by ISSUER or its managers, involving race or gender discrimination, child labor, slave labor, workplace or sexual harassment, or environmental crime; (v) failure by ISSUER and other codebtors under this Note to comply with any of the obligations set forth herein, including those provided in subsection 7.1; (vi) supply of irregular and/or false information to the São Paulo State Development Agency and/or to the BNDES by ISSUER and by the other codebtors in order to obtain the loan that is the subject matter of this Note; (vii) occurrence of a legitimate protested instrument or any other judicial or extrajudicial action against ISSUER, which may in any way prevent compliance with the obligations assumed by it hereunder; (viii) insolvency of ISSUER, request for court-supervised or out-of-court reorganization, or bankruptcy; (ix) interruption of the activities of ISSUER for more than thirty (30) days, except for interruption of the activities of ISSUER during sugarcane off-season; (x) assignment or transfer by ISSUER to third parties of the rights and obligations hereunder without the prior and express consent of the São Paulo State Development Agency; (xi) if ISSUER fails to grant, substitute and/or supplement personal guarantee(s) or security interest(s) granted hereunder within thirty (30) days after a request by the São Paulo State Development Agency in this respect, in case these personal guarantee(s) or security

6



interest(s) are not duly given or if they otherwise become unable, inadequate or insufficient to guarantee full payment of the debt; (xii) if ISSUER fits any of the provisions of articles 39 and 40 of the Provisions Applicable to the BNDES agreements; (xii) provision of false representations and/or information provided and required under subsection 3.13.6 of Exhibit I to BNDES Circular No. 33/2011, without prejudice to imposition of the applicable statutory penalties; (xiv) if ISSUER fits any other events contemplated in articles 333 and 1425 of the Brazilian Civil Code.
5.1.1. In the events set forth in items (i) and (ii) of subsection 5.1, ISSUER shall be subject, as from the day following the day established by means of an official or extrajudicial notification, to a fine of fifty percent (50%) of the amount released and not proved, plus the charges due as agreed hereunder until the date of actual payment of the debt.
5.2. In the event of failure to comply with any statutory or contractual obligation, even in the event of late payment of any installment of the principal and charges, as well as in the event of early maturity of this Note as provided in subsection 5.1, ISSUER and the other codebtors shall be put in default, by operation of law and regardless of any warning or notice, in which case they shall be required to pay, as from the date of the corresponding default, the Delinquency Charges represented by the Permanence Commission and interest for late payment, at the rates set forth in the corresponding Field of TABLE V, without prejudice, should this be the case, of imposition of the fine referred to in subsection 5.1.1.
5.2.1. The delinquency charges set forth in subsection 5.2 shall apply and be due on a daily basis, from the date of default to the date of actual payment, levied on the outstanding amount of the debt.
5.2.2. ISSUER and the other codebtors shall also be liable for all expenses related to collection of the unpaid debt, including protest, and of the other debts contemplated in this Note, and if the São Paulo State Development Agency goes to the courts to recover its credit, for the attorneys' fees set forth by the court and for the other court expenses.

7



VI - LOAN GUARANTEES
6.1. In order to guarantee full compliance with all main and ancillary obligations, in the form and under the conditions set forth in this Note, individually or along with other guarantees, the CORPORATE GUARANTEE is granted as provided in subsection 6.2 of TABLE VI, subject to the other conditions contemplated in the corresponding instrument of guarantee (i.e. Corporate Guarantee), which shall be an integral part hereof.
6.2. In addition, in order to fully comply with all main and ancillary obligations assumed under this Note, individually or along with other guarantees, ISSUER transfers to the São Paulo State Development Agency the Property described and characterized in the “INSTRUMENT OF FIDUCIARY SALE OF PERSONAL PROPERTY”, which shall be an integral part hereof for all legal purposes and effects.
VII - SPECIAL CONDITIONS
7.1. In addition to the other conditions set forth in this Note, ISSUER further agrees to: (i) invest the funds provided hereunder exclusively to carry out the venture that is the subject matter of this Note, pursuant to the conditions approved by the BNDES/FINAME and by the São Paulo State Development Agency; (ii) not to change the venture supported by the funds granted hereunder, so as not to reduce the ability or deviate the purpose thereof, without the prior and express consent of the BNDES/FINAME; (iii) to prove, should this be the case, the accurate use of its own funds, in the proportion and form and under the conditions set forth in this Note and/or in the budget; (iv) to comply, to the extent applicable, with the “PROVISIONS APPLICABLE TO BNDES AGREEMENTS”, as approved by Resolution No 665, of December 10, 1987, as amended; (v) to comply, to the extent applicable, with the “GENERAL CONDITIONS GOVERNING TRANSACTIONS” with respect to the FINAME , which shall be carried out pursuant to Decree No. 59.170, of September 2, 1966, microfilmed under No. 399.674, entered in the annotations column of Record No. 4.879, of Book H-9, in the 2 nd Registry of Deeds and Documents of the Judicial District of Rio de Janeiro, State of Rio de Janeiro; (vi) to comply, to the extent applicable, with the rules related to processing of the credit transactions established by the BNDES/FINAME ¸ which it hereby declares to know and agrees to accept; (vii) to grant the BNDES/FINAME ¸ either directly or through the São Paulo State Development Agency , free access to its premises and to its accounting or legal records, for purposes of controlling the financial cooperation contemplated in this Note, providing any and all pieces of information upon request; (viii) to expressly mention the BNDES/FINAME cooperation and the participation of the São Paulo State Development Agency as financing entities, whenever it advertises the Property and the use thereof, it being understood that such disclosure shall be subject to the prior approval of the São Paulo State Development Agency and of the BNDES; (ix) to comply with the provisions of the law related to the National Environmental Policy, adopting, during the term of effectiveness of this Note, measures and actions intended to avoid or remedy damages caused to the environment, to labor safety and occupational health that may be caused by the financed property; (x) to maintain its obligations to the environmental authorities in regular standing during the term of effectiveness of this Note; (xi) to observe, during the term of effectiveness of this Note, the provisions of the applicable law concerning persons with special needs; (xii) neither to assign nor to transfer the rights and obligations hereunder, as well as neither to sell nor in any way dispose of or encumber the Property that is the subject matter of the Loan without the express authorization of the São Paulo State Development Agency and/or of the BNDES/FINAME , under penalty of early maturity hereof by operation of law, pursuant to the provisions of item V , without prejudice to the other applicable measures and penalties; (xiii) to prove, at the request of the São Paulo State Development Agency , compliance with the special conditions set forth in items (ix) and (x) ; (xiv) to prove, in transactions secured by pledge or fiduciary assignment of credit rights, that debtor is aware, should this be the case, of the credits pledged or subject to the fiduciary sale, as provided in this Note, by means of a notice to be made through a Registry of Deeds and Documents or by means of a public or private instrument registered with the Registries of Deeds and Documents of the Judicial District of the domicile of lender and of the Judicial District of the domicile of borrower of the credit rights granted to secure this Note; (xv) to keep the São Paulo State Development Agency permanently informed of its technical and economic conditions, including with respect to amendments to its Articles of Incorporation or Organization, as well as to promptly provide, upon request, reports, information and statements within the required term; (xvi) to comply, until full settlement of the debt assumed hereunder, all rules and regulations issued by the FINAME/BNDES and other regulatory agencies; (xvii) to maintain the Property pledged as guarantee in perfect conditions of operation and conservation, requiring and causing compliance, with respect to such Property, with all warranties offered by the sellers or manufacturers; (xviii) to assume all risks against third parties, exempting the São Paulo State Development Agency from any liability, as well as to inform the São Paulo State Development Agency , within five (5) days, of any event that could depreciate the Property pledged as guarantee; (xix) to visibly affix to the equipment that is the subject matter of this Loan and referred to in TABLE IV an identification label informing at least

8



the corporate name or acronym of ISSUER , year of manufacture and serial or identification number of the financed property; (xx) to update and keep available to the São Paulo State Development Agency and to the BNDES , whenever applicable, until full payment of the loan, the records required in subsection 3.13.6 of Exhibit I to Circular No. 33/2011, as the case may be (only in the transactions with Beneficiaries engaged, among others, in the planting, renewal and costing of crops, and also the processing of sugarcane for the production of ethanol and other sugarcane-derived biofuels, and sugar, except for brown sugar, pursuant to the codes 0113-0/00, 1071-6/00, 1072-4/01 and 1931-4/00 of the CNAE, as disclosed by the IBGE); (xxi) to carry an insurance covering the Property subject to the Fiduciary Sale, as provided in the “Instrument of Fiduciary Sale of Personal Property” referred to in subsection 6.2, during effectiveness of this Note.
7.2. The São Paulo State Development Agency may, at any time and at its discretion, require reinforcement of the guarantee to cover any possible increase in the debit balance as a result of the adjustment of the amount of the debt that results in a disproportional relation between the Amount of the Loan granted hereunder and the amount of the guarantees pledged hereunder, or in any other case this action is required, including in order to recompose the Guarantee, in which case ISSUER shall provide this reinforcement within thirty (30) days as from the date of request by the São Paulo State Development Agency .
7.2.1 The guarantees given in this transaction shall not jeopardize São Paulo State Development Agency's right to directly request from ISSUER and the other codebtors immediate compliance with any outstanding payment obligation, and ISSUER and the other codebtors cannot claim any order of preference of guarantees.
VIII - FINAL PROVISIONS
8.1. ISSUER acknowledges that the following documents are valid and effective and shall be an integral part hereof for all legal purposes and effects: (i) the Instrument of Fiduciary Sale of Personal Property and other documents that are an integral part thereof; (ii) the correspondence exchanged between the São Paulo State Development Agency and ISSUER, including electronically, which have been regularly received by the corresponding addressee, as well as of all documents resulting from this Note; (iii) the review and inspection report(s) of the Property given as Guarantee, as provided in this Note; (iv) the PAYMENT SCHEDULE; (v) the Credit Extension Offer (PAC) (copy).

9



8.2. ISSUER and the other CODEBTORS acknowledge, pursuant to the provisions of article 28 of Law No. 10931/2004, as proof of the net, certain and payable debt, pursuant to the provisions of this Note, the debt assessed by the São Paulo State Development Agency by means of a Calculation Spreadsheet or Balance Statement issued by the São Paulo State Development Agency in connection with this instrument, containing the corresponding entries made in accordance with the provisions hereof, provided the right of recovery in the event of processing error.
8.3. Pursuant to the applicable law, the São Paulo State Development Agency may endorse, assign and transfer this Note and all rights and guarantees set forth herein, subrogating to all rights, interests and prerogatives of the endorsee or assignee under the endorsement, assignment and transfer, and it is hereby authorized by ISSUER to do so.
8.4. ISSUER irrevocably and irreversibly authorizes the São Paulo State Development Agency to: (i) provide the Central Bank of Brazil with information on the amount of the debts and liabilities assumed under this Note, including, but not limited to, the Credit Information System (SCR), pursuant to the provisions of Resolution No. 3658 of the Brazilian Monetary Council, of December 2008; (ii) access the information of the same regulatory agency, as provided by the other financial institutions; and to (iii) provide, in the event of default, information to the State Register of Defaulters (CADIN), which was created by State Law No. 12799, of January 11, 2008, pursuant to the provisions of article 4 thereof.
8.5. Notwithstanding any provision to the contrary herein, before declaring the early maturity for any reason, or before the imposition of any pecuniary or other penalty, the São Paulo State Development Agency agrees to send written notice to ISSUER, informing of the default and granting ISSUER a term of five (5) days after receipt of such notice to cure such default(s).
8.6. No forbearance by the São Paulo State Development Agency with respect to failure to perform or default of obligations, conditions and terms set forth in this Note shall result in novation or desistence, it being understood that it may not be invoked, under any circumstance, by ISSUER and the other codebtors hereunder and under the Instrument of Fiduciary Sale of Personal Property.

10



IX - JURISDICTION
9.1. The parties elect the Central Courts of the Judicial District of the Capital City of the State of São Paulo as competent to resolve any possible dispute under this Note , provided the parties hereby waive any other court, no matter how privileged it may be, provided NOSSA CAIXA DESENVOLVIMENTO's right to bring actions in the Court of the domicile of ISSUER .
São Paulo, July 13, 2012.
ISSUER
/s/ Paulo Diniz /s/ Felipe M. Caram
AMYRIS BRASIL LTDA

I AGREE
JULY 13, 2012
NOSSA CAIXA DESENVOLVIMENTO - AGÊNCIA DE FOMENTO DO ESTADO DE SÃO PAULO
/s/ Gilberto Fioravante              /s/ Ana Paula Alves Shuay    
Gilberto Fioravante            Ana Paula Alves Shuay
Business and Operations Supervisor    Business and Operations Supervisor

NOSSA CAIXA DESENVOLVIMENTO SERVICE CENTER: (11) 3123-0464
OFFICE OF THE OMBUDSMAN: 0800-7706272
EMAIL: ouvidoria@desenvolvesp.com.br

11



EXHIBIT TO THE BANK CREDIT NOTE
- PAYMENT SCHEDULE -
Number of the Note
2766
Amount of the Note
 R$30,000,000.00
Maturity Date
July 15, 2022
Type of Credit
BNDES FINAME - PSI
City of Payment
São Paulo - State of São Paulo
ISSUER
Corporate Name
AMYRIS BRASIL LTDA
CNPJ/MF
09.379.224/0001-20
Address
R James Clerk Maxwell, 315, Techno Park
City
Campinas
State
São Paulo
Payment of the principal and charges with respect to the Note identified in the corresponding Fields of TABLE V hereof shall be made in accordance with the following SCHEDULE, which shall be an integral and inseparable part of the aforementioned Note :
PAYMENT SCHEDULE
Installment No.
Date of Payment
Type
1
October 15, 2012
E
2
January 15, 2013
E
3
April 15, 2013
E
4
July 15, 2013
E
5
October 15, 2013
E
6
January 15, 2014
E
7
April 15, 2014
E
8
July 15, 2014
E
9
August 15, 2014
P+E
10
September 15, 2014
P+E
11
October 15, 2014
P+E
12
November 15, 2014
P+E
13
December 15, 2014
P+E
14
January 15, 2015
P+E
15
February 15, 2015
P+E
16
March 15, 2015
P+E
17
April 15, 2015
P+E
18
May 15, 2015
P+E
19
June 15, 2015
P+E
20
July 15, 2015
P+E
21
August 15, 2015
P+E
22
September 15, 2015
P+E
23
October 15, 2015
P+E
24
November 15, 2015
P+E
25
December 15, 2015
P+E
26
January 15, 2016
P+E
27
February 15, 2016
P+E
28
March 15, 2016
P+E
29
April 15, 2016
P+E
30
May 15, 2016
P+E

12



31
June 15, 2016
P+E
32
July 15, 2016
P+E
33
August 15, 2016
P+E
34
September 15, 2016
P+E
35
October 15, 2016
P+E
36
November 15, 2016
P+E
37
December 15, 2016
P+E
38
January 15, 2017
P+E
39
February 15, 2017
P+E
40
March 15, 2017
P+E
41
April 15, 2017
P+E
42
May 15, 2017
P+E
43
June 15, 2017
P+E
44
July 15, 2017
P+E
45
August 15, 2017
P+E
46
September 15, 2017
P+E
47
October 15, 2017
P+E
48
November 15, 2017
P+E
49
December 15, 2017
P+E
50
January 15, 2018
P+E
51
February 15, 2018
P+E
52
March 15, 2018
P+E
53
April 15, 2018
P+E
54
May 15, 2018
P+E
55
June 15, 2018
P+E
56
July 15, 2018
P+E
57
August 15, 2018
P+E
58
September 15, 2018
P+E
59
October 15, 2018
P+E
60
November 15, 2018
P+E
61
December 15, 2018
P+E
62
January 15, 2019
P+E
63
February 15, 2019
P+E
64
March 15, 2019
P+E
65
April 15, 2019
P+E
66
May 15, 2019
P+E
67
June 15, 2019
P+E
68
July 15, 2019
P+E
69
August 15, 2019
P+E
70
September 15, 2019
P+E
71
October 15, 2019
P+E
72
November 15, 2019
P+E
73
December 15, 2019
P+E
74
January 15, 2020
P+E
75
February 15, 2020
P+E

13



76
March 15, 2020
P+E
77
April 15, 2020
P+E
78
May 15, 2020
P+E
79
June 15, 2020
P+E
80
July 15, 2020
P+E
81
August 15, 2020
P+E
82
September 15, 2020
P+E
83
October 15, 2020
P+E
84
November 15, 2020
P+E
85
December 15, 2020
P+E
86
January 15, 2021
P+E
87
February 15, 2021
P+E
88
March 15, 2021
P+E
89
April 15, 2021
P+E
90
May 15, 2021
P+E
91
June 15, 2021
P+E
92
July 15, 2021
P+E
93
August 15, 2021
P+E
94
September 15, 2021
P+E
95
October 15, 2021
P+E
96
November 15, 2021
P+E
97
December 15, 2021
P+E
98
January 15, 2022
P+E
99
February 15, 2022
P+E
100
March 15, 2022
P+E
101
April 15, 2022
P+E
102
May 15, 2022
P+E
103
June 15, 2022
P+E
104
July 15, 2022
P+E

NB: For purposes of identification of the payment installments pursuant to the schedule, (i) “E” refers to the exclusive payments of charges; and “P+E” refers to the payment of an installment of principal and charges.

14



CONFIDENTIAL TREATMENT REQUESTED. CERTAIN PORTIONS OF THIS DOCUMENT HAVE BEEN OMITTED PURSUANT TO A REQUEST FOR CONFIDENTIAL TREATMENT AND, WHERE APPLICABLE, HAVE BEEN MARKED WITH AN ASTERISK TO DENOTE WHERE OMISSIONS HAVE BEEN MADE. THE CONFIDENTIAL MATERIAL HAS BEEN FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION.


BANK CREDIT NOTE
TABLE I - INFORMATION ON THE NOTE
Number of the Note
089/2012
Maturity Date
July 15, 2022
Amount of the Note
R$22,000,000.00
Type of Credit
BNDES FINAME - PSI
PAC Number
66.716-1
PAC Approved on
July 12, 2012
City of Payment
São Paulo - State of São Paulo
TABLE II - LENDER
BANCO PINE S.A. , with its principal place of business in the Capital City of the State of São Paulo, at Avenida das Nações Unidas, 8501 - 29 th and 30 th floor, building Eldorado Business Tower, Pinheiros, enrolled with the CNPJ/MF under No. 62.144.175/0001-20.
BNDES Authorization

Nr. 482-0
TABLE III - ISSUER
Corporate Name
AMYRIS BRASIL LTDA
CNPJ/MF
09.379.224/0001-20
Address
R James Clerk Maxwell, 315
District
Techno Park
City
Campinas
State
 São Paulo
Postal Code
13.069-380
Checking Account No.
31692
Branch
001-9
Bank
643
TABLE IV - PURPOSE OF THE LOAN AND PROPERTY SELLER
The Loan agreed under this Bank Credit Note shall be used for acquisition of the property described below, for the construction of an industrial plant for the Farnesene Production System at Paraíso plant, in the City of Brotas, State of São Paulo.
Description of the Financed Property
Units
1
Model
FARNESENE PRODUCTION SYSTEM, MOD. PEBR 10106
Product Code/FINAME
2887533
Price of the Property
R$82,410,000.00
Seller
Corporate Name
GEA ENGENHARIA DE PROCESSOS E SISTEMAS INDUSTRIAIS LTDA
CNPJ/MF
49.070.824/0001-27
Address
AV. Mercedes Benz, 679 - BUILDING 4D2 FLOOR 1 P
District
Distrito Industrial
City
Campinas
State
São Paulo
Postal Code
13.054-750
Checking Account No.
41595-0
Branch
1370
Bank
341
TABLE V - CHARACTERISTICS OF THE TRANSACTION

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Total Price of the Financed Project
R$82,410,000.00
Amount of the Loan
R$22,000,000.00
TCC Amount
NIHIL
Amortization Period
96 months
Grace Period
24 months
Financial Burden
Nominal Interest Rate
0.4472% per month
Nominal Interest Rate

5.3660% per year
Actual Interest Rate

5.5% per year
CET

5.57% per year
Delinquency Charges
Permanence Commission
8.9% per month
Interest for Late Payment
1% per month
TABLE VI - GUARANTEES
6.1. CORPORATE GUARANTEE
Name/Corporate Name of the Surety
Amyris Inc.
CNPJ/MF
09.345.642/0001-05
Address
5885 Hollis Street, Suite 100 - Emeryville, CA 94608 - United States of America
Legal Representative(s)
João Gabriel Alves de Melo
Identification Document
Passport: [*]
Nationality
Portuguese
Title
CEO and President
6.2. FIDUCIARY SALE OF PERSONAL PROPERTY
Pursuant to the “Instrument of Fiduciary Sale of Personal Property”, which is an integral part of this Bank Credit Note.
CONDITIONS APPLICABLE TO THE BANK CREDIT NOTE
I - OFFER OF PAYMENT

1.1. ISSUER and the other codebtors offer to pay by this Bank Credit Note (Note or CCB), in favor of BANCO PINE S.A. (PINE or LENDER), or to its order, at the “City of Payment” and on the “Maturity” date set forth in TABLE I, the amount set forth in the Field “Amount of the Note”, which corresponds to the “Amount of the Loan”, which shall be increased by the Financial Burdens set forth in TABLE V and, should this be the case, by the statutory burdens and the Delinquency Charges contemplated herein, representing a net, certain and payable obligation to pay such amount in cash, pursuant to the provisions of article 29, item II of Law No. 10931/2004.
II - RELEASE OF THE LOAN
2.1. Pursuant to the applicable statutory provisions, the PINE grants ISSUER , within the scope of the BNDES Investment Maintenance Program ( BNDES-PSI ), the credit approved by Agência Especial de Financiamento Industrial - FINAME , a state-owned company created by Law No. 5662, of June 21, 1971, as agent of the Brazilian Bank of Economic and Social Development - BNDES , in the amount set forth in the Field “Amount of the Loan” mentioned in TABLE V , which is intended for acquisition of the Property/Equipment described in TABLE IV , in accordance with the budget presented to the Consortium LEADER , as provided in sub-item 2.1.1.

[*] Certain portions denoted with an asterisk have been omitted and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested with respect to the omitted portions.


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2.1.1. ISSUER hereby represents that it is aware of and agrees to the fact that the loan for acquisition of the Property/Equipment described in TABLE IV is made by means of a Consortium between the Financial Agents, the São Paulo State Development Agency and PINE, pursuant to the provisions of the General Conditions included in EXHIBIT VIII to BNDES Circular No. 33/2011, of September 1 st , 2011, it being understood that PINE is designated the Consortium LEADER (LEADER), as agreed by the Consortium members.
2.1.2. It is hereby agreed that the PINE is exempted from any liability with respect to the dependency, availability and sufficiency of funds of the BNDES-PSI/FINAME, as required for completion of this Loan, it being understood that in the event of unavailability and/or insufficiency of funds of the BNDES, this Note shall be automatically cancelled, regardless of any judicial or extrajudicial notification, in which case ISSUER shall not be entitled to damages or redress as a result of failure to release the corresponding credit.
2.2. The funds shall be released by the PINE within up to one (1) business day as from actual release by the BNDES/FINAME or, in the event of releases in installments, the releases shall be made as set forth in the Release Schedule attached to the Credit Extension Offer (PAC) presented by the LEADER , as duly approved by the BNDES/FINAME , to which this Note is copied and which shall become an integral part hereof for all purposes and effects.
2.2.1. Release of the funds shall be further conditional upon: (i) proof of due investment of the installment previously released/used, in the event of release in installments; (ii) proof by ISSUER of the actual and regular pledge of the guarantee contemplated in subsection 6.2 of TABLE VI, as provided in the Instrument of Fiduciary Sale of Personal Property, which is an integral part hereof, granted in favor of the São Paulo State Development Agency and of PINE; (iii) inexistence of any fact that, at the discretion of the BNDES and/or of the PINE, significantly changes the economic and financial situation of ISSUER, or which may jeopardize performance of the subject matter of the loan in order to change it or to prevent performance thereof, pursuant to the provisions of the Project ratified by the BNDES/FINAME; (iv) presentation, by ISSUER, of a Debt Clearance Certificate - CND or Certificate of Suspended Debt Liability - CPD-EN, issued by the Brazilian Federal Revenue Service by the INTERNET, to be extracted by ISSUER and verified by the PINE at the addresses: www.previdenciasocial.gov.br or www.receita.fazenda.gov.br , except if such proof is waived as a result of a statutory and/or normative provision; (v) proof, should this be the case, of regular standing with respect to the environmental authorities or, if such proof has already been presented and is in effect, a statement by ISSUER in this respect; (vi) payment, should this be the case, of the expenses referred to in subsection 3.4.1.
2.3. Subject to the other conditions set forth in this Note, the funds to be released hereunder shall be directly credited to the deposit account held by SELLER, as described in TABLE IV, or to its order to ISSUER, by means of bank transfer(s) in the amount mentioned in the corresponding Field “Amount of the Loan” referred to in TABLE V, by means of presentation of the corresponding Tax document(s), in which case ISSUER irrevocably and irreversibly authorizes the PINE to adopt the procedure set forth herein, giving full and general release with respect to receipt of the amount then released.

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2.3.1. The release(s) referred to in subsection 2.3 may be made by means of Wire Transfer of Immediately Available Funds (TED) , Credit Document or transfer between accounts held with the same Institution, to an account held by SELLER or by whomever SELLER indicates.
2.3.2. Whenever the amount to be released is transferred by means of Wire Transfer of Immediately Available Funds (TED) or Credit Document (DOC) , ISSUER shall be liable for reimbursement of the fee charged by the corresponding Financial Institution, plus any possible tax levied thereon, pursuant to the Third-Party Services Expenses Reimbursement Table, as disclosed on PINE'S website: www.pine.com.br ; in which case ISSUER agrees to pay such amount by means of a Bank Bill to be issued by the PINE or as otherwise defined by it.
III - FINANCIAL BURDEN AND OTHER LOAN EXPENSES
3.1. The Interest levied on the “Amount of the Loan” is set forth in the Field “Interest Rate” in TABLE V, and the following formula shall be adopted:
J n = SD n-1 {(1 + i /100} N/360 - 1}
J n : Interest to be paid by ISSUER , in Brazilian Reais (R$), at the time “n”;
SD n-1 : Debit Balance, in R$, at the time “n-1”;
i : five point five percent (5.5%);
N: number of days between the date of the financial event and the date of capitalization, maturity or performance of the obligation, it being understood that financial event shall be understood as any and all financial facts that result or may result in a change in the debit balance of this Note.
3.1.1. The Interest shall be payable: (i) on a quarterly basis, during the grace period; and (ii) on a monthly basis, during the amortization period, along with payment of the installments of principal, and upon maturity or payment of the Note.
3.1.2. The “Interest Rate” set forth in TABLE V already includes the remunerations due to the BNDES and to the PINE.
3.2. In the event of substitution of the legal criterion of Remuneration of the funds transferred to the BNDES from the Social Integration Program of the Public Servant Fund (PIS/PASEP) and from the Workers Support Fund - FAT, the remuneration set forth in this Note may, at the discretion of the BNDES/FINAME, be made by means of use of the new remuneration criterion applicable to said funds, or by another criterion indicated by the BNDES/FINAME itself, which, in addition to preserving the actual amount of the transaction, remunerates it in the same previous levels, in which case the PINE shall give ISSUER written notice thereof.

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3.3. In case the BNDES/FINAME so requires, on the dates of release of the funds or of cancelation of the transaction, ISSUER shall pay the Credit Reserve Commission, which shall correspond to zero point one percent (0.1%) per month, to be levied on the amount of the corresponding release or of the cancelled balance, as from the date of approval of the PAC.
3.4. In addition to the charges referred to in subsection 3.1., ISSUER and the other Codebtors are required to pay: (i) all taxes or legal expenses levied or that come to be levied on this transaction, in the form and at the rates set forth in the applicable law; (ii) other statutory charges, or charges contemplated in the regulations issued by the Central Bank of Brazil (BACEN), BNDES/FINAME; (iii) of the Credit Extension Fee (TCC), in the amount set forth in TABLE V, and of the Reimbursement of the Credit Release Fee (TED and DOC), as set forth in subsection 2.3.2.
3.4.1. The amounts related to the charges set forth in subsection 3.4, should this be the case, shall be paid by ISSUER before release of the credit, it being understood that failure to make this payment shall authorize the PINE to suspend the corresponding release, without prejudice to the other penalties set forth in this Note.
3.5. ISSUER shall also pay to the PINE, should this be the case, fees and/or fee reimbursement, pursuant to the provisions of the “Fee Table” and/or of the “Third-Party Services Expenses Reimbursement Table” available at PINE'S address: www.pine.com.br .
3.5.1. The payments referred to in subsections 3.4.1 and 3.5 shall be made by ISSUER by means of Bank Bills issued in favor of the PINE, in any bank that participates in the Bank Clearance System, or by any other means permitted by the PINE.
3.6. Without prejudice to the other provisions of this item III, ISSUER represents, for all purposes and effects, that before formalization of the Transaction that is the subject matter hereof, it became aware and is aware of the percentage relating to the Total Actual Cost (CET) mentioned in TABLE V, as well as of the calculation flows thereof, with which it hereby agrees.
3.6.1 ISSUER is aware of and agrees to the fact that calculation of the annual CET percentage referred to in subsection 3.6 took into consideration the flows relating to the scheduled release(s) and payment(s), including the Interest Rate agreed hereunder, taxes, fees, insurance and other expenses on the Loan, in addition to those related to payment of the third-party services agreed by the PINE.
IV - DEBT PROCESSING AND COLLECTION
4.1. ISSUER and the other codebtors under this Note agree to pay the Loan, subject to the grace period, in accordance with the monthly installments and on the maturity dates mentioned in the Schedule set forth in the EXHIBIT - PAYMENT SCHEDULE, which, after read and initialed by the parties, shall be an integral part of this Note for all purposes and effects.
4.1.1. Subject to the provisions of the corresponding Field of TABLE V, the grace period shall start on the fifteenth (15 th ) day of the month, after the date of issuance/execution hereof.
4.1.2. During the grace period, ISSUER and the other codebtors agree to quarterly pay the Interest accrued in the period, in accordance with the criteria set forth in this Note, which term shall commence on the date referred to in subsection 4.1.1.

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4.1.3. During the term of amortization, ISSUER and the other codebtors agree to pay the principal of the Loan, by means of monthly and successive installments, each of which in the unmatured amount of the principal, divided by the number of unmatured installments, plus the monthly interest set forth in this Note, it being understood that the first installment shall be due on the fifteenth (15 th ) day of the month following the end of the grace period.
4.2. Collection of the principal and charges shall be made by means of a Bank Bill, which shall have the same effects as a Collection Notice, and which shall be sent by the PINE to ISSUER and contain the required amount for payment of the corresponding installment on the maturity date, to be paid in any bank that participates in the Bank Clearance System.
4.2.1. The provisions of subsection 4.2 does not exempt ISSUER and the other codebtors from the obligation to timely pay the installments of the Loan on the dates set forth in this Note, including in case the bank bills have not been received by ISSUER, for any reason, it being understood that ISSUER shall be liable for the late payment charges set forth herein in the event of late payment.
4.2.2. If ISSUER and the other codebtors fail to pay the installment(s), including charges, on the agreed date(s), these installments shall be added to the debit balance of this transaction, and in the event of nonperformance and/or default, the permanence commission, interest and fine, as provided in Item V of this Note, shall apply to the unpaid amount of the debt.
4.2.3. In case any installment of the principal and/or charges is due on a Saturday, Sunday or national holiday, including bank holidays, such maturity date shall be, for all purposes and effects, transferred to the first subsequent business day, it being understood that the charges shall be calculated by such date, on which the next regular period of assessment and calculation of the transaction charges shall commence.
4.3. ISSUER may prepay the debt, except in the event BNDES has the right to refuse prepayment, it being hereby agreed that: (i) if partial prepayment is accepted, such prepayment shall be proportionally used to cover the unmatured installments of principal, maintaining the same maturity dates and adopting the same remuneration and calculation criteria set forth in this Note; (ii) if prepayment of the total amount of the debt is accepted, the same remuneration and calculation criteria set forth in this Note shall be adopted.
4.3.1. In addition, in the event of prepayment of the total amount of the debt, the other obligations to do or not to do assumed by ISSUER shall be maintained until the maturity date set forth in this Note, especially the obligation to carry out the project that is the subject matter of this Loan within the agreed term, it being understood that the PINE and the BNDES shall be entitled to inspect conduction of the project.
4.3.2. In the event of verification of irregular investment of funds during an inspection conducted pursuant to the provisions of subsection 4.3.1., ISSUER shall be subject to the penalties imposed by the BNDES and to those described in this Note.
4.3.3. In the event of nonperformance and/or default, ISSUER and the other codebtors hereby irrevocably and irreversibly authorize the PINE to offset, pursuant to the provisions of article 368 of the Brazilian Civil Code, its credit, as represented by the debit balance hereof, against any cash and cash equivalents they may own, either currently existing or that come to exist in the future, including as a result of other credit transactions possibly released to ISSUER.

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V - EARLY MATURITY OF THE LOAN AND DELINQUENCY CHARGES
5.1. The early maturity of this Note shall be declared, in which case the whole debt shall become immediately payable, including the charges set forth herein, with immediate suspension of the release of any disbursement to ISSUER, should this be the case, upon occurrence of the following events: (i) failure by ISSUER to physically or financially prove conduction of the project that is the subject matter of the financial cooperation with respect to the Loan agreed hereunder; (ii) investment of the funds granted hereunder for other purposes than those set forth in TABLE IV hereof; (iii) inexistence of or failure to update or to provide the PINE and the BNDES with the records required under subsection 3.13.6 of Exhibit I to Circular No. 33/2011, as the case may be (only in the transactions with Beneficiaries engaged, among others, in the planting, renewal and costing of crops, and also the processing of sugarcane for the production of ethanol and other sugarcane-derived biofuels, and sugar, except for brown sugar, pursuant to the codes 0113-0/00, 1071-6/00, 1072-4/01 and 1931-4/00 of the National Code of Economic Activity (CNAE) disclosed by the Brazilian Institute of Geography and Statistics (IBGE); (iv) existence of an unappealable adverse judgment as a result of the practice of actions, by ISSUER or its managers, involving race or gender discrimination, child labor, slave labor, workplace or sexual harassment, or environmental crime; (v) failure by ISSUER and other codebtors under this Note to comply with any of the obligations set forth herein, including those provided in subsection 7.1; (vi) supply of irregular and/or false information to the PINE and/or to the BNDES by ISSUER and by the other codebtors in order to obtain the loan that is the subject matter of this Note; (vii) occurrence of a legitimate protested instrument or any other judicial or extrajudicial action against ISSUER, which may in any way prevent compliance with the obligations assumed by it hereunder; (viii) insolvency of ISSUER, request for court-supervised or out-of-court reorganization, or bankruptcy; (ix) interruption of the activities of ISSUER for more than thirty (30) days, except for interruption of the activities of ISSUER during sugarcane off-season; (x) assignment or transfer by ISSUER to third parties of the rights and obligations hereunder without the prior and express consent of the PINE; (xi) if ISSUER fails to grant, substitute and/or supplement personal guarantee(s) or security interest(s) granted hereunder within thirty (30) days after a request by the PINE in this respect, in case these personal guarantee(s) or security interest(s) are not duly given or if they otherwise become unable, inadequate or insufficient to guarantee full payment of the debt; (xii) if ISSUER fits any of the provisions of articles 39 and 40 of the Provisions Applicable to the BNDES agreements; (xii) provision of false representations and/or information provided and required under subsection 3.13.6 of Exhibit I to BNDES Circular No. 33/2011, without prejudice to imposition of the applicable statutory penalties; (xiv) if ISSUER fits any other events contemplated in articles 333 and 1425 of the Brazilian Civil Code.
5.1.1. In the events set forth in items (i) and (ii) of subsection 5.1, ISSUER shall be subject, as from the day following the day established by means of an official or extrajudicial notification, to a fine of fifty percent (50%) of the amount released and not proved, plus the charges due as agreed hereunder until the date of actual payment of the debt.

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5.2. In the event of failure to comply with any statutory or contractual obligation, even in the event of late payment of any installment of the principal and charges, as well as in the event of early maturity of this Note as provided in subsection 5.1, ISSUER and the other codebtors shall be put in default, by operation of law and regardless of any warning or notice, in which case they shall be required to pay, as from the date of the corresponding default, the Delinquency Charges represented by the Permanence Commission and interest for late payment, at the rates set forth in the corresponding Field of TABLE V, without prejudice, should this be the case, of imposition of the fine referred to in subsection 5.1.1.
5.2.1. The delinquency charges set forth in subsection 5.2 shall apply and be due on a daily basis, from the date of default to the date of actual payment, levied on the outstanding amount of the debt.
5.2.2. ISSUER and the other codebtors shall also be liable for all expenses related to collection of the unpaid debt, including protest, and of the other debts contemplated in this Note, and if the PINE goes to the courts to recover its credit, for the attorneys' fees set forth by the court and for the other court expenses.
VI - LOAN GUARANTEES
6.1. In order to guarantee full compliance with all main and ancillary obligations, in the form and under the conditions set forth in this Note, individually or along with other guarantees, the CORPORATE GUARANTEE is granted as provided in subsection 6.2 of TABLE VI, subject to the other conditions contemplated in the corresponding instrument of guarantee (i.e. Corporate Guarantee), which shall be an integral part hereof.
6.2. In addition, in order to fully comply with all main and ancillary obligations assumed under this Note, individually or along with other guarantees, ISSUER transfers to the PINE the Property described and characterized in the “INSTRUMENT OF FIDUCIARY SALE OF PERSONAL PROPERTY”, which shall be an integral part hereof for all legal purposes and effects.
VII - SPECIAL CONDITIONS
7.1. In addition to the other conditions set forth in this Note, ISSUER further agrees to: (i) invest the funds provided hereunder exclusively to carry out the venture that is the subject matter of this Note, pursuant to the conditions approved by the BNDES/FINAME and by the PINE; (ii) not to change the venture supported by the funds granted hereunder, so as not to reduce the ability or deviate the purpose thereof, without the prior and express consent of the BNDES/FINAME; (iii) to prove, should this be the case, the accurate use of its own funds, in the proportion and form and under the conditions set forth in this Note and/or in the budget; (iv) to comply, to the extent applicable, with the “PROVISIONS APPLICABLE TO BNDES AGREEMENTS”, as approved by Resolution No 665, of December 10, 1987, as amended; (v) to comply, to the extent applicable, with the “GENERAL CONDITIONS GOVERNING TRANSACTIONS” with respect to the FINAME , which shall be carried out pursuant to Decree No. 59.170, of September 2, 1966, microfilmed under No. 399.674, entered in the annotations column of Record No. 4.879, of Book H-9, in the 2 nd Registry of Deeds and Documents of the Judicial District of Rio de Janeiro, State of Rio de Janeiro; (vi) to comply, to the extent applicable, with the rules related to processing of the credit transactions established by the BNDES/FINAME ¸ which it hereby declares to know and agrees to accept;

8



(vii) to grant the BNDES/FINAME ¸ either directly or through the PINE , free access to its premises and to its accounting or legal records, for purposes of controlling the financial cooperation contemplated in this Note, providing any and all pieces of information upon request; (viii) to expressly mention the BNDES/FINAME cooperation and the participation of the PINE as financing entities, whenever it advertises the Property and the use thereof, it being understood that such disclosure shall be subject to the prior approval of the PINE and of the BNDES; (ix) to comply with the provisions of the law related to the National Environmental Policy, adopting, during the term of effectiveness of this Note, measures and actions intended to avoid or remedy damages caused to the environment, to labor safety and occupational health that may be caused by the financed property; (x) to maintain its obligations to the environmental authorities in regular standing during the term of effectiveness of this Note; (xi) to observe, during the term of effectiveness of this Note, the provisions of the applicable law concerning persons with special needs; (xii) neither to assign nor to transfer the rights and obligations hereunder, as well as neither to sell nor in any way dispose of or encumber the Property that is the subject matter of the Loan without the express authorization of the PINE and/or of the BNDES/FINAME , under penalty of early maturity hereof by operation of law, pursuant to the provisions of item V , without prejudice to the other applicable measures and penalties; (xiii) to prove, at the request of the PINE , compliance with the special conditions set forth in items (ix) and (x) ; (xiv) to prove, in transactions secured by pledge or fiduciary assignment of credit rights, that debtor is aware, should this be the case, of the credits pledged or subject to the fiduciary sale, as provided in this Note, by means of a notice to be made through a Registry of Deeds and Documents or by means of a public or private instrument registered with the Registries of Deeds and Documents of the Judicial District of the domicile of lender and of the Judicial District of the domicile of borrower of the credit rights granted to secure this Note; (xv) to keep the PINE permanently informed of its technical and economic conditions, including with respect to amendments to its Articles of Incorporation or Organization, as well as to promptly provide, upon request, reports, information and statements within the required term; (xvi) to comply, until full settlement of the debt assumed hereunder, all rules and regulations issued by the FINAME/BNDES and other regulatory agencies; (xvii) to maintain the Property pledged as guarantee in perfect conditions of operation and conservation, requiring and causing compliance, with respect to such Property, with all warranties offered by the sellers or manufacturers; (xviii) to assume all risks against third parties, exempting the PINE from any liability, as well as to inform the PINE , within five (5) days, of any event that could depreciate the Property pledged as guarantee; (xix) to visibly affix to the equipment that is the subject matter of this Loan and referred to in TABLE IV an identification label informing at least the corporate name or acronym of ISSUER , year of manufacture and serial or identification number of the financed property; (xx) to update and keep available to the PINE and to the BNDES , whenever applicable, until full payment of the loan, the records required in subsection 3.13.6 of Exhibit I to Circular No. 33/2011, as the case may be (only in the transactions with Beneficiaries engaged, among others, in the planting, renewal and costing of crops, and also the processing of sugarcane for the production of ethanol and other sugarcane-derived biofuels, and sugar, except for brown sugar, pursuant to the codes 0113-0/00, 1071-6/00, 1072-4/01 and 1931-4/00 of the CNAE, as disclosed by the IBGE); (xxi) to carry an insurance covering the Property subject to the Fiduciary Sale, as provided in the “Instrument of Fiduciary Sale of Personal Property” referred to in subsection 6.2, during effectiveness of this Note.

9



7.2. The PINE may, at any time and at its discretion, require reinforcement of the guarantee to cover any possible increase in the debit balance as a result of the adjustment of the amount of the debt that results in a disproportional relation between the Amount of the Loan granted hereunder and the amount of the guarantees pledged hereunder, or in any other case this action is required, including in order to recompose the Guarantee, in which case ISSUER shall provide this reinforcement within thirty (30) days as from the date of request by the PINE .
7.2.1 The guarantees given in this transaction shall not jeopardize PINE's right to directly request from ISSUER and the other codebtors immediate compliance with any outstanding payment obligation, and ISSUER and the other codebtors cannot claim any order of preference of guarantees.
VIII - FINAL PROVISIONS
8.1. ISSUER acknowledges that the following documents are valid and effective and shall be an integral part hereof for all legal purposes and effects: (i) the Instrument of Fiduciary Sale of Personal Property and other documents that are an integral part thereof; (ii) the correspondence exchanged between the PINE and ISSUER, including electronically, which have been regularly received by the corresponding addressee, as well as of all documents resulting from this Note; (iii) the review and inspection report(s) of the Property given as Guarantee, as provided in this Note; (iv) the PAYMENT SCHEDULE; (v) the Credit Extension Offer (PAC) (copy).
8.2. ISSUER and the other CODEBTORS acknowledge, pursuant to the provisions of article 28 of Law No. 10931/2004, as proof of the net, certain and payable debt, pursuant to the provisions of this Note, the debt assessed by the PINE by means of a Calculation Spreadsheet or Balance Statement issued by the PINE in connection with this instrument, containing the corresponding entries made in accordance with the provisions hereof, provided the right of recovery in the event of processing error.
8.3. Pursuant to the applicable law, the PINE may endorse, assign and transfer this Note and all rights and guarantees set forth herein, subrogating to all rights, interests and prerogatives of the endorsee or assignee under the endorsement, assignment and transfer, and it is hereby authorized by ISSUER to do so.
8.4. ISSUER irrevocably and irreversibly authorizes the PINE to: (i) provide the Central Bank of Brazil with information on the amount of the debts and liabilities assumed under this Note, including, but not limited to, the Credit Information System (SCR), pursuant to the provisions of Resolution No. 3658 of the Brazilian Monetary Council, of December 2008; (ii) access the information of the same regulatory agency, as provided by the other financial institutions; and to (iii) provide, in the event of default, information to the State Register of Defaulters (CADIN), which was created by State Law No. 12799, of January 11, 2008, pursuant to the provisions of article 4 thereof.
8.5. Notwithstanding any provision to the contrary herein, before declaring the early maturity for any reason, or before the imposition of any pecuniary or other penalty, the PINE agrees to send written notice to ISSUER, informing of the default and granting ISSUER a term of five (5) days after receipt of such notice to cure such default(s).
8.6. No forbearance by the PINE with respect to failure to perform or default of obligations, conditions and terms set forth in this Note shall result in novation or desistence, it being understood that it may not be invoked, under any circumstance, by ISSUER and the other codebtors hereunder and under the Instrument of Fiduciary Sale of Personal Property.

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IX - JURISDICTION
9.1. The parties elect the Central Courts of the Judicial District of the Capital City of the State of São Paulo as competent to resolve any possible dispute under this Note , provided the parties hereby waive any other court, no matter how privileged it may be, provided PINE's right to bring actions in the Court of the domicile of ISSUER .
São Paulo, July 13, 2012.
ISSUER
/s/ Paulo Diniz /s/ Felipe M. Caram
AMYRIS BRASIL LTDA

I AGREE
JULY 13, 2012
BANCO PINE S.A.
/s/ illegible              /s/ illegible    

BANCO PINE S.A. SERVICE CENTER: (11) 3372- 5200
OFFICE OF THE OMBUDSMAN: 0800-7257463
EMAIL: ouvidoria.pine@pine.com.br


11



EXHIBIT TO THE BANK CREDIT NOTE
- PAYMENT SCHEDULE -
Number of the Note
089/2012
Amount of the Note
 R$22,000,000.00
Maturity Date
July 15, 2022
Type of Credit
BNDES FINAME - PSI
City of Payment
São Paulo - State of São Paulo
ISSUER
Corporate Name
AMYRIS BRASIL LTDA
CNPJ/MF
09.379.224/0001-20
Address
R James Clerk Maxwell, 315, Techno Park
City
Campinas
State
São Paulo
Payment of the principal and charges with respect to the Note identified in the corresponding Fields of TABLE V hereof shall be made in accordance with the following SCHEDULE, which shall be an integral and inseparable part of the aforementioned Note :
PAYMENT SCHEDULE
Installment No.
Date of Payment
Type
1
October 15, 2012
E
2
January 15, 2013
E
3
April 15, 2013
E
4
July 15, 2013
E
5
October 15, 2013
E
6
January 15, 2014
E
7
April 15, 2014
E
8
July 15, 2014
E
9
August 15, 2014
P+E
10
September 15, 2014
P+E
11
October 15, 2014
P+E
12
November 15, 2014
P+E
13
December 15, 2014
P+E
14
January 15, 2015
P+E
15
February 15, 2015
P+E
16
March 15, 2015
P+E
17
April 15, 2015
P+E
18
May 15, 2015
P+E
19
June 15, 2015
P+E
20
July 15, 2015
P+E
21
August 15, 2015
P+E
22
September 15, 2015
P+E
23
October 15, 2015
P+E
24
November 15, 2015
P+E
25
December 15, 2015
P+E
26
January 15, 2016
P+E
27
February 15, 2016
P+E
28
March 15, 2016
P+E
29
April 15, 2016
P+E
30
May 15, 2016
P+E
31
June 15, 2016
P+E
32
July 15, 2016
P+E

12



33
August 15, 2016
P+E
34
September 15, 2016
P+E
35
October 15, 2016
P+E
36
November 15, 2016
P+E
37
December 15, 2016
P+E
38
January 15, 2017
P+E
39
February 15, 2017
P+E
40
March 15, 2017
P+E
41
April 15, 2017
P+E
42
May 15, 2017
P+E
43
June 15, 2017
P+E
44
July 15, 2017
P+E
45
August 15, 2017
P+E
46
September 15, 2017
P+E
47
October 15, 2017
P+E
48
November 15, 2017
P+E
49
December 15, 2017
P+E
50
January 15, 2018
P+E
51
February 15, 2018
P+E
52
March 15, 2018
P+E
53
April 15, 2018
P+E
54
May 15, 2018
P+E
55
June 15, 2018
P+E
56
July 15, 2018
P+E
57
August 15, 2018
P+E
58
September 15, 2018
P+E
59
October 15, 2018
P+E
60
November 15, 2018
P+E
61
December 15, 2018
P+E
62
January 15, 2019
P+E
63
February 15, 2019
P+E
64
March 15, 2019
P+E
65
April 15, 2019
P+E
66
May 15, 2019
P+E
67
June 15, 2019
P+E
68
July 15, 2019
P+E
69
August 15, 2019
P+E
70
September 15, 2019
P+E
71
October 15, 2019
P+E
72
November 15, 2019
P+E
73
December 15, 2019
P+E
74
January 15, 2020
P+E
75
February 15, 2020
P+E
76
March 15, 2020
P+E
77
April 15, 2020
P+E
78
May 15, 2020
P+E
79
June 15, 2020
P+E
80
July 15, 2020
P+E

13



81
August 15, 2020
P+E
82
September 15, 2020
P+E
83
October 15, 2020
P+E
84
November 15, 2020
P+E
85
December 15, 2020
P+E
86
January 15, 2021
P+E
87
February 15, 2021
P+E
88
March 15, 2021
P+E
89
April 15, 2021
P+E
90
May 15, 2021
P+E
91
June 15, 2021
P+E
92
July 15, 2021
P+E
93
August 15, 2021
P+E
94
September 15, 2021
P+E
95
October 15, 2021
P+E
96
November 15, 2021
P+E
97
December 15, 2021
P+E
98
January 15, 2022
P+E
99
February 15, 2022
P+E
100
March 15, 2022
P+E
101
April 15, 2022
P+E
102
May 15, 2022
P+E
103
June 15, 2022
P+E
104
July 15, 2022
P+E

NB: For purposes of identification of the payment installments pursuant to the schedule, (i) “E” refers to the exclusive payments of charges; and “P+E” refers to the payment of an installment of principal and charges.

14


INSTRUMENT OF FIDUCIARY SALE OF PERSONAL PROPERTY
I - PARTIES
A)- LENDERS
1. Corporate Name: Banco Pine S.A., hereinafter referred to as PINE .
CNPJ/MF
62.144.175/0001-20
Address:  Avenida das Nações Unidas, 8501, 29 th  and 30 th  Floors - Ed. Eldorado Business Tower, Pinheiros, São Paulo, State of São Paulo
Postal Code:  05425-070
2. Corporate Name:  Nossa Caixa Desenvolvimento - Agência de Fomento do Estado de São Paulo S.A., hereinafter referred to as NOSSA CAIXA DESENVOLVIMENTO .
CNPJ/MF  
10.663.610/0001-29
Address:  Rua da Consolação, 371 - Consolação, São Paulo, State of São Paulo
Postal Code:  01301-000
B)- BORROWER
Corporate Name:  
AMYRIS BRASIL LTDA
CNPJ/MF:
09.379.224/0001-20
Address:
Rua James Clerk Maxwell, 315 - Techno Park - Campinas, State of São Paulo
Postal Code:
13.069-380
C)- DEPOSITARY(IES)
Name:  AMYRIS BRASIL LTDA
CNPJ/MF:
09.379.224/0001-20
Address:
Rua James Clerk Maxwell, 315 - Techno Park
City:  
CAMPINAS
State:  
SÃO PAULO
II - CREDIT INSTRUMENTS
A)- Name:
BANK CREDIT NOTE
Number:
089/2012
Date:
July 13, 2012
Loan Amount:
TWENTY-TWO MILLION BRAZILIAN REAIS (R$22,000,000.00)
Term:
ONE HUNDRED AND TWENTY (120) months
Interest Rate:
5.50% p.a.
Lender:  BANCO PINE S/A
B)- Name
BANK CREDIT NOTE
Number
2766
Date: (Issuance/execution)
July 13, 2012
Loan Amount:
THIRTY MILLION BRAZILIAN REAIS (R$30,000,000.00)
Term:
ONE HUNDRED AND TWENTY (120) months
Interest Rate:
5.50% p.a.
Lender:  NOSSA CAIXA DESENVOLVIMENTO

1




III - PROPERTY SUBJECT TO THE FIDUCIARY SALE
A)- Description:
01 - FARNESENE PRODUCTION SYSTEM, MOD. PEBR 10106, FINAME CODE: 288.753-3.
B)- Place where the Property shall be Deposited
RODOVIA BROTAS/TORRINHA S/N, KM 7.5 - FAZENDA PARAÍSO - BROTAS, STATE OF SÃO PAULO
IV - CLAUSES AND CONDITIONS
The parties named and identified in TABLE I hereof hereby mutually agree to the Secured Fiduciary Sale of the personal property described and characterized in TABLE III hereof, which shall be governed, in general, by the applicable laws and regulations, and especially by the clauses and conditions below, which the parties mutually grant and accept and agree to duly comply with and observe, on their behalf and on behalf of their successors.
SECTION ONE - In order to guarantee full and due comp liance with all main and ancillary obligations assumed by BORROWER under the Credit Instruments described in TABLE II hereof, individually or in addition to other guarantees, BORROWER , as lawful owner, hereby lawfully transfers the Property described and characterized in TABLE III hereof to the LENDERS identified in TABLE I of the preamble by means of a Fiduciary Sale, in accordance with the provisions of article 66-B of Law No. 4728, of July 14, 1965, as amended by Law 10931, of August 3, 2004, of Decree-Law No. 911, of October 1 st , 1969, as amended by Law 10931/2004, and in article 1361 et seq. of the Brazilian Civil Code.
SECTION TWO - BORROWER hereby represents, for all legal purposes and effects and subject to the penalties of law, that it has full title and peaceable possession of the property subject to this Secured Fiduciary Sale and that said property is completely free and clear of any and all liens, debts, doubts or disputes, as well as of any connection to any other obligation assumed to third parties.
Sole Paragraph - As a result of the Fiduciary Sale agreed hereunder, LENDERS , as holders of the title, possession and of the rights and actions on such property, hereby authorize BORROWER to maintain the direct and precarious possession thereof until full compliance with all obligations assumed under the Credit Instruments referred to in TABLE II hereof, for which reason it shall be liable for all obligations and burdens as depositary of this property, pursuant to the civil and criminal law.

2



SECTION THREE - BORROWER agrees to take out, within at most fifteen (15) days after the date of execution hereof, an all-risk insurance covering all risks that may result in loss, deterioration or deficiency of the property subject to the fiduciary sale, and carry such insurance during the term of effectiveness of the Credit Instruments referred to in TABLE II hereof, indicating PINE as the first beneficiary of this insurance, so that in the event of loss the indemnity is directly paid to PINE by the Insurance Company.
Paragraph One - If the property subject to the fiduciary sale is already covered by insurance with the same characteristics mentioned in the head provision of this section, BORROWER hereby agrees to include, in the respective policy or policies, the beneficiary provision set forth therein.
Paragraph Two - The indemnity received by PINE under this section may be used by LENDERS for amortization or payment of the debt under the Credit Instruments referred to in TABLE II hereof.
Paragraph Three - If the indemnity received by PINE from the Insurance Company under this section, even if for total loss , and regardless of the cause of the loss, including act of God or force majeure, is not sufficient to satisfy in full the credit of LENDERS under the Credit Instruments referred to in TABLE II hereof, BORROWER shall remain liable for the balance.
Paragraph Four - If the Insurance is taken out for a shorter term than the term of the Loans under the Credit Instruments referred to in TABLE II hereof, BORROWER agrees to renew the Insurance of the property subject to the fiduciary sale upon termination of the corresponding Policy, submitting copies of the new Policies to LENDERS .
Paragraph Five - Failure to prove that the Insurance covering the property pursuant to the provisions of this section was taken out and maintained shall result in the early maturity of the Credit Instruments referred to in TABLE II and imposition of the penalties set forth therein.
Paragraph Six - Without prejudice to the other provisions of this section, BORROWER agrees to maintain the property subject to fiduciary sale hereunder in perfect state of conservation, as well as to defend it from nuisance by third parties, therefore assuming the liabilities and statutory liens attributed to the depositary, it being understood that liabilities resulting from the possession and/or use of the property, including tax and criminal liabilities, even if resulting from act of God or force majeure or caused by third-party actions, shall be exclusively assumed by BORROWER .

3



SECTION FOUR - BORROWER may neither assign, sell, give, give in payment, lease or pledge as security nor transfer in any way, wholly or in part, the property subject to fiduciary sale, under penalty of imposition of the sanctions set forth in article 171, paragraph 2 of the Penal Code.
SECTION FIVE - At any time, regardless of early or timely maturity of the secured debt, BORROWER may amicably deliver, no judicial or extrajudicial measure being required, the property subject to the fiduciary sale to LENDERS , which may keep it, should this be the case, in their possession until payment of all obligations secured hereunder and, in the event of default - or earlier - sell such property, in the form and for the effects set forth in Decree-Law No. 911/1969, as well as in article 66-B of Law No. 4728/1965, as amended by Law No. 10931/2004.
Paragraph One - In the event of default, BORROWER shall provide LENDERS , within the term set forth in the notice contemplated in section thirteen, with the property subject to the fiduciary sale, under penalty of judicial seizure thereof, in which case LENDERS are hereby authorized and irrevocably and irreversibly vested in the right to sell such property to third parties and use the proceeds of the sale for payment of their credits, pursuant to the provisions of the corresponding Credit Instruments referred to in TABLE II hereof, including all expenses resulting from collection and sale of the Property, delivering any resulting balance to BORROWER .
Paragraph Two - If the proceeds of the sale of the property subject to the fiduciary sale are not sufficient for payment of LENDERS' credits in full, including the expenses resulting from collection and sale of the Property, BORROWER shall remain liable until final and full payment of the remaining debt.
Paragraph Three - In case LENDERS do not wish to or cannot sell the property of which they are the fiduciary owners, they are entitled to enforce the debt against BORROWER , pursuant to the provisions of the corresponding Credit Instruments referred to in TABLE II hereof.
Paragraph Four - If the proceeds of the sale of the property subject to the fiduciary sale are not sufficient for full payment of LENDERS' credit, as provided in the Credit Instruments referred to in TABLE II hereof, including the collection expenses, BORROWER shall remain liable until final and full payment of the debts under said Credit Instruments.

4



SECTION SIX - This security shall remain valid and effective until full compliance with the obligations of BORROWER agreed under the Credit Instruments referred to in TABLE II hereof, including any possible renewal thereof and amendment thereto.
SECTION SEVEN - BORROWER irrevocably and irreversibly agrees to provide, at its expenses, within: (i) five (5) business days after execution hereof or of any amendment hereto, proof of filing of a request for registration hereof or of the respective amendment hereto with the Registry of Deeds and Documents of the Judicial District of the City of Brotas, State of São Paulo; and (ii) thirty (30) consecutive days after execution hereof or of any amendment hereto, proof of registration hereof or of the respective amendment hereto with the Registries of Deeds and Documents of the Judicial Districts of the Cities of Brotas, Campinas and São Paulo, in the State of São Paulo.
SECTION EIGHT - BORROWER irrevocably and irreversibly authorizes LENDERS to offset, as provided in article 368 of the Brazilian Civil Code and other applicable rules, any debt related to the security given hereunder and/or under the Credit Instruments referred to in TABLE II hereof against any current or future credit of BORROWER , whether due or coming due. The aforementioned setoff especially involves, without limitation, credits represented by bonds or securities, fixed-income bonds, balances in freely operated accounts, financial investments, bank deposit certificates or any other bond or obligation, and it shall apply in any event of default by BORROWER , which shall have a three (3)-business day term to cure the alleged default upon receipt of formal notice by LENDERS . In the event of credits coming due, LENDERS are authorized by BORROWER to declare the maturity thereof on the same maturity dates of the obligations assumed hereunder or under the secured Credit Instruments for the amounts to be offset.
Sole Paragraph - All payments to LENDERS set forth herein or agreed hereunder or under the secured Credit Instruments shall be credited to or debited from the bank account held by BORROWER , as the case may be, by means of any appropriate transfer and bank credit instrument. BORROWER agrees to maintain sufficient balance for timely payment of the amounts due hereunder and under the secured Credit Instruments.
SECTION NINE - The Depositaries identified in TABLE IV hereof execute this Instrument and represent that they have full knowledge of and agree with the provisions hereof, expressly accepting all burdens inherent to Depositaries as provided by Law, and they hereby agree to maintain the property received for deposit at a safe place, promoting the integrity and conservation thereof, as well as to deliver it to LENDERS upon request, under penalty of being imposed the sanctions set forth in the applicable law.

5



SECTION TEN - BORROWER and the Depositaries hereby allow LENDERS to examine and inspect the property subject to fiduciary sale pursuant to the provisions hereof, including by means of their authorized representatives, which shall be granted by BORROWER and/or Depositaries free access to the facilities where such property is deposited.
SECTION ELEVEN - This Instrument is an integral and inseparable part of the Credit Instruments referred to in TABLE II, forming one sole instrument for all legal purposes and effects.
Sole Paragraph - The parties hereby confirm, for all due purposes and effects, all terms, clauses and conditions of the Credit Instruments referred to in TABLE II hereof, which shall remain unchanged.
SECTION TWELVE - The parties elect the Central Courts of the Judicial District of São Paulo, State of São Paulo, to resolve all disputes hereunder, provided the parties hereby waive any other court, no matter how privileged it may be.
SECTION THIRTEEN - The parties agree that notwithstanding any provision to the contrary herein, before LENDERS declare the early maturity for any reason, or before the imposition of any fine or other penalty, LENDERS agree to send BORROWER written notice of the default, granting BORROWER a five (5)-day term as from receipt of such notice for it to cure such default.
SECTION FOURTEEN - Upon full payment of the Loans agreed under the Instruments mentioned in TABLE II, LENDERS agree to issue an Instrument of Release with respect to the Fiduciary Sale of the Property pledged as security within up to thirty (30) consecutive days after receipt of the notice sent by BORROWER .

6



SECTION FIFTEEN - BORROWER AND THE DEPOSITARIES REPRESENT, FOR ALL PURPOSES AND EFFECTS, THAT THEY HAVE READ AND AGREED TO ALL CONDITIONS SET FORTH HEREIN, INCLUDING IN THE PREAMBLE HEREOF.
IN WITNESS WHEREOF, the parties execute this instrument in four (4) counterparts of equal form and substance, for the same effect, in the presence of the two (2) undersigned witnesses.
São Paulo, July 13, 2012.
LENDER: BANCO PINE S.A.
/s/ illegible          /s/ José Quarezemin    
Formalization Manager

LENDER: NOSSA CAIXA DESENVOLVIMENTO - AGÊNCIA DE
FOMENTO DO ESTADO DE SÃO PAULO S.A.

/s/ Gilberto Fioravante          /s/ Ana Paula Alves Shuay    
Business and Operations Supervisor    Business and Operations Supervisor

BORROWER: AMYRIS BRASIL LTDA
/s/ Paulo Diniz          /s/ Felipe M. Caram    


DEPOSITARY: AMYRIS BRASIL LTDA
/s/ Paulo Diniz          /s/ Felipe M. Caram    


WITNESSES:
/s/ Anderson Antonio Fernandes                  /s/ Laerte Casarini Jr.            
Name: Anderson Antonio Fernandes            Name: Laerte Casarini Jr.
ID: illegible                        ID: illegible


7


        
FINAL
CORPORATE GUARANTEE (Amyris)
GUARANTEE (as the same may be amended, supplemented or otherwise modified from time to time, the “ Guarantee ”), dated July 13, 2012 of Amyris, Inc., a corporation organized under the laws of the State of Delaware (the “ Guarantor ”) in favor of NOSSA CAIXA DESENVOLVIMENTO - AGÊNCIA DE FOMENTO DO ESTADO DE SÃO PAULO S.A., its successors and assigns (the “ Beneficiary ”).
WHEREAS , Amyris Brasil Ltda. a sociedade limitada formed under the laws of the Federative Republic of Brazil, (the “ Primary Obligor ”) has entered into the CCB - Cédula de Crédito Bancário dated July 13, 2012 (as amended, modified and supplemented from time to time, the “ Financing Agreement ”), with the Beneficiary, under which the Beneficiary has agreed to provide to the Primary Obligor credit in Brazilian Reais in the amount of R$ 30,000,000.00, for the development of an industrial farnesene producing unit in Brotas, State of São Paulo, subject to the conditions provided therein;
WHEREAS , in consideration of all transactions to which the Guarantee relates already entered into and to be entered into after the date hereof under the Financing Agreement, and in return for substantial direct and indirect benefits to the Guarantor, the Guarantor has agreed to guarantee the payment of all amounts owed from time to time, and performance from time to time, due by the Primary Obligor under the Financing Agreement; and
WHEREAS , the Beneficiary also has the benefit of a security interest over machinery and equipment of the Primary Obligor pursuant to Quadro 6.2 of the Financing Agreement and any other security interests set out therein or in ancillary agreements (as amended, modified and supplemented from time to time, the “ Collateral ,” and together with the Financing Agreement, the “Financing Documents”).
NOW, THEREFORE, the Guarantor hereby agrees:
Section 1. The Guarantee . (a) From and after the date hereof, the Guarantor hereby irrevocably guarantees to the Beneficiary the payment of all present and future amounts (whether absolute or contingent, and whether for principal, interest, scheduled payments, termination amounts, fees, breakage costs, expenses, indemnification, contractual penalty, interest on deferred payments, or otherwise) owing by the Primary Obligor under or in respect of the Financing Agreement or any other Financing Documents, as and when such amounts become due and payable, whether at their scheduled due dates, upon acceleration, termination or otherwise (or would otherwise be owing, due or payable under the Financing Agreement but for the commencement of any bankruptcy, insolvency or similar proceeding in respect of the Primary Obligor) (such obligations, the “ Payment Obligations ”) and the performance of all delivery and other obligations of the Primary Obligor under the Financing Agreement or any other Financing Documents in accordance with the terms of the Financing Agreement or any other Financing Documents (the “ Performance Obligations ” and, together with the Payment Obligations, the “ Guaranteed Obligations ”). The Beneficiary shall have the option to demand payment of the Guaranteed Obligations from the Guarantor in U.S. Dollars or Brazilian Reais.

1



This is a guarantee of payment and performance, and not merely of collection. The Guarantor further agrees to pay all costs, fees and expenses (including, without limitation, fees of outside counsel) incurred by the Beneficiary in connection with enforcing or exercising rights under this Guarantee or arising from a breach by the Guarantor of the provisions hereof or any misrepresentation made by the Guarantor herein.
(b)    In no event shall the Beneficiary be obligated to take any action, obtain any judgment or file any claim prior to enforcing this Guarantee. Upon failure of the Primary Obligor punctually to pay or perform any Guaranteed Obligations, the Guarantor agrees promptly to pay or perform or cause to be paid or performed such Guaranteed Obligations. The rights, powers, remedies and privileges provided in this Guarantee are cumulative and not exclusive of any rights, powers, remedies and privileges provided by any other agreement or by law.
(c)    The Guarantor hereby agrees that this is an absolute and unconditional, continuing and unlimited guarantee.
(d)    The Guarantor hereby waives any claims relating to, and permits, as applicable:
(1) the invalidity, irregularity or unenforceability of the Financing Agreement or this Guarantee or any other Financing Documents or any other agreement related to the Financing Agreement or this Guarantee or any other Financing Documents;
(2) the lack of authority of Primary Obligor to execute or deliver the Financing Agreement or any other Financing Documents;
(3) any change in the time, manner or place of payment of, or in any other term of, or amendment to the Financing Agreement or any other Financing Documents;
(4) any change in amount, nature or otherwise, or discharge in connection with the Collateral;
(5) any waiver or consent by the Beneficiary with respect to any provisions of the Financing Agreement or any other Financing Documents or any compromise or release of any of the obligations thereunder;
(6) the absence of any action to enforce the Financing Agreement or any other Financing Documents, to recover any judgment against the Primary Obligor or to enforce a judgment against the Primary Obligor under the Financing Agreement or any other Financing Documents;
(7) the occurrence of any event of default or potential event of default under the Financing Agreement or any other Financing Documents;
(8) the existence of any bankruptcy, insolvency, reorganization or similar proceedings involving the Primary Obligor or its assets;

2



(9) other than payment of any amounts due hereunder, any setoff, counterclaim, or defense of any kind or nature which may be available to or asserted by the Guarantor or the Primary Obligor against the Beneficiary or any of its affiliates;
(10) any impairment, taking, furnishing, exchange or release of, or failure to perfect or obtain protection of the Collateral or any other security interest in, collateral securing the Financing Agreement or any other obligation of the Primary Obligor;
(11) any change in the laws, rules or regulations of any jurisdiction;
(12) any present or future action of any governmental authority or court amending, varying, reducing or otherwise affecting, or purporting to amend, vary, reduce or otherwise affect, any of the obligations of the Primary Obligor under the Financing Agreement or any other Financing Documents or of Guarantor under this Guarantee;
(13) any claim as to the validity, regularity or enforceability of the subrogation rights provided in Section 3 below;
(14) any other circumstance (other than payment or performance) which might otherwise constitute a legal or equitable discharge or defense of a guarantor generally; or

(15) any change in the corporate existence, structure or ownership of the Primary Obligor, or any release or discharge of the Guaranteed Obligations.
(e)    The Guarantor hereby further waives diligence, presentment, demand on the Primary Obligor for payment or otherwise, filing of claims, requirement of a prior proceeding against the Primary Obligor and protest or notice. If at any time (including any time after termination or expiration of this Guarantee) payment under the Financing Agreement or any other Financing Documents is rescinded or must be otherwise restored or returned by the Beneficiary upon the insolvency, bankruptcy or reorganization of the Primary Obligor or the Guarantor or otherwise, the Guarantor's obligations hereunder with respect to such payment shall be reinstated upon such restoration or return being made by the Beneficiary, all as though such payment had not been made.
(f)    The Guarantor hereby agrees that, absent manifest error, the internal records of the Beneficiary setting forth the outstanding amount or the status of the Guaranteed Obligations are binding and conclusive proof of the amounts owed, or performance due, under the Financing Agreement and any other Financing Documents.
(g)    The Guarantor shall remain liable for the Guaranteed Obligations until the Guaranteed Obligations are irrevocably paid in full in accordance with this Guarantee and with the Financing Agreement, and nothing except irrevocable payment in full of all Guaranteed Obligations in accordance with this Guarantee and with the Financing Agreement shall release the Guarantor from its obligations under this Guarantee.
(h)    The Beneficiary shall have no obligation to disclose or discuss with the Guarantor their assessment, or any assessment by any other person, of the financial or other condition of the Primary Obligor; the Beneficiary shall have no obligation to investigate the financial or other

3



condition of the Primary Obligor; the Guarantor has adequate means to obtain information from the Primary Obligor on a continuing basis concerning the financial and other condition of the Primary Obligor and its ability to perform its obligations and discharge its liabilities as they become due; and the Guarantor assumes full responsibility for being and keeping informed of the financial and other condition of the Primary Obligor and of all circumstances bearing upon the risk of nonpayment of the Guaranteed Obligations to the extent the Guarantor desires to be kept so informed.
(i)    The Beneficiary may enforce this Guarantee upon the occurrence and during the continuance of a breach by the Primary Obligor of any of its obligations under the Financing Documents, notwithstanding the existence of any dispute between the Primary Obligor and the Beneficiary or any other party with respect to the existence of such breach or any other matter.
(j)    The Beneficiary may, at its election, foreclose on any security held by it in one or more judicial or nonjudicial sales, accept an assignment of any such security in lieu of foreclosure, compromise or adjust any part of the Guaranteed Obligations, make any other accommodation with the Primary Obligor or any other guarantor or exercise any other right or remedy available to it against the Primary Obligor, without affecting or impairing in any way the liability of the Guarantor hereunder except to the extent the Guaranteed Obligations then due and owing have been fully paid.
Section 2. Representations and Warranties. The Guarantor represents and warrants to the Beneficiary on the date hereof and, except as otherwise indicated, during the duration of this Guarantee that:
(a)    it has reviewed and is familiar with the terms of the Financing Documents;
(b)    it is duly organized and validly existing under the laws of the jurisdiction of its organization and has full power and legal right to execute and deliver this Guarantee and to perform the provisions of this Guarantee on its part to be performed;
(c)    its execution, delivery and performance of this Guarantee have been and remain duly authorized by all necessary organizational action and do not contravene any provision of its certificate of incorporation or by-laws, or any law, regulation or rule applicable to it or contractual restriction binding on it or its assets;
(d)    all consents, authorizations, approvals and clearances (including, without limitation, any necessary exchange control approval) and notifications, reports and registrations requisite for the due execution, delivery and performance of this Guarantee have been obtained from or, as the case may be, filed with the relevant governmental authorities having jurisdiction and remain in full force and effect and all conditions thereof have been duly complied with and no other action by, and no notice to, or filing with, any governmental authority having jurisdiction is required for such execution, delivery or performance;
(e)    this Guarantee is the valid and binding and enforceable obligation of the Guarantor;

4



(f)    the Guarantor and a wholly-owned subsidiary of Guarantor, together, own all the equity interest in the Primary Obligor and Guarantor acknowledges that it will receive substantial direct and indirect benefits from the transactions contemplated by the Financing Agreement and that its waivers of suretyship and other defenses are knowingly made in contemplation of such benefits;
(g)    on the date hereof and on the date of each disbursement under the Financing Agreement, after giving effect to this Guarantee, the aggregate fair saleable value of all of the Guarantor's property, at fair valuation, will be greater than the sum of all the Guarantor's liabilities of any nature, including without limitation contingent and unmatured debts or claims (“ Liabilities ”);
(h)    it has not transferred, concealed or removed any of its property with the intent to hinder, delay or defraud its creditors, nor is it now making this Guarantee with intent to hinder, delay or defraud its creditors;
(i)    on the date hereof and on the date of each disbursement under the Financing Agreement, after giving effect to this Guarantee, the value of its remaining assets is not unreasonably small in relation to its business as contemplated thereon or with respect to any transaction contemplated or undertaken thereafter;
(j)    on the date hereof and on the date of each disbursement under the Financing Agreement, it has not incurred and does not intend to incur, or believe (or reasonably believe) that it will incur Liabilities beyond its ability to pay as such Liabilities mature;
(k)    it has satisfied in full any final judgment against it in an action or suit for money damages which judgment results from an action or suit pending against it on or prior to the date hereof and there is no action or suit for money damages pending against it on or prior to the date hereof;
(l)    there are no other proceedings pending or, to the knowledge of the Guarantor, threatened against the Guarantor, at law or in equity, which, individually or in the aggregate, if adversely determined, would materially adversely affect the financial condition of the Guarantor or materially impair the Guarantor's ability to perform its obligations under this Guarantee;
(m)     none of its controlling shareholders, executive officers, members of its board of directors and their respective legal representatives, nor any of their family members or affiliates are politically exposed persons. For the purpose of this paragraph a “politically exposed person” means a person who is or has been entrusted in the last five years, in Brazil or in any other jurisdiction or territory, with any prominent public function, job or position, including, without limitation, head of state or government, high-ranking political appointments or elected politicians, high-ranking civil service positions, high-ranking judicial or military posts and chief of any corporation owned by a government, a governmental agency or political parties. Individuals in middle-ranking or more junior positions within the foregoing categories are excluded from the definition of “politically exposed persons”; and

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(n)    none of its controlling shareholders, executive officers, managers, directors and their affiliates are subject to any financial sanctions of the United Nations Organization - UN, nor are they included in any financial sanctions lists in connection with terrorism or money laundering.
Section 3. Subrogation of Rights. By accepting this Guarantee and entering into the Financing Agreement, the Guarantor shall be subrogated to all rights of the Beneficiary against the Primary Obligor in respect of any amounts paid or performance by the Guarantor pursuant to this Guarantee, provided that the Guarantor shall be entitled to enforce or to receive any payment or performance arising out of or based upon such right of subrogation only when all amounts payable and all performance to be effected by the Primary Obligor under the Financing Agreement and the other Financing Documents have been paid and performed and the Financing Agreement has been terminated. The Guarantor agrees that it will not take any action against or in respect of the Primary Obligor relating to any payment or performance made by the Guarantor under this Guarantee until such time as the Guaranteed Obligations shall have been paid and performed in full and the Financing Agreement has been terminated.
Section 4. Covenants. (a)    So long as any Guaranteed Obligations remain outstanding or any Financing Documents remain in effect, the Guarantor shall not, without the prior written consent of the Beneficiary, commence or join with, or take any action in furtherance of, any other person in commencing any bankruptcy proceeding of or against Primary Obligor. The obligations of the Guarantor under this Guarantee shall not be reduced, limited, impaired, discharged, deferred, suspended or terminated by any bankruptcy proceeding of or against the Primary Obligor or by any defense that the Primary Obligor may have by reason of any order, decree or decision of any court or administrative body resulting from or relating to any such bankruptcy proceeding or the existence of such bankruptcy proceeding.
(b)    The Guarantor hereby agrees that until such time as all of the Guaranteed Obligations shall be paid and performed in full, the Subordinated Indebtedness (as hereinafter defined) is and shall be expressly subordinated, to the extent and in the manner hereinafter set forth, in right of payment to the prior payment of the Guaranteed Obligations.
The term "Subordinated Indebtedness" shall mean, at any time, the then outstanding aggregate principal amount of all indebtedness of the Primary Obligor to the Guarantor in respect of borrowed money, fees, royalties or other advance or arrangement (including any subrogation rights with respect to this Guaranty), all accrued and unpaid interest and premium, if any, thereon and all expenses incurred by and all indemnities payable to the Guarantor pursuant to any agreement between the Primary Obligor and the Guarantor in respect of any such indebtedness or otherwise.
Upon the happening of any breach by the Primary Obligor under the Financing Documents, unless and until such breach shall have been remedied or waived, no direct or indirect payment (in cash, property or securities or by set-off or otherwise) shall be made or agreed to be made on account of the Subordinated Indebtedness and the Guarantor shall not demand, collect or receive any payment on account of the Subordinated Indebtedness.

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(c)    All payments made or deemed made by the Guarantor hereunder or under the Financing Agreement shall be made free and clear of, and without deduction for any present or future income, excise, stamp or franchise taxes and other taxes, fees, duties, withholdings or other charges of any nature whatsoever imposed by any taxing authority (such items being herein referred to as “Taxes”). In the event that any withholding or deduction from any payment to be made or deemed to be made by the Guarantor hereunder or under the Financing Agreement is required in respect of any Taxes pursuant to any applicable law, rule, regulation, then the Guarantor will:
(i)    pay directly to the relevant authority the full amount required to be so withheld or deducted;
(ii)    promptly forward to the Beneficiary an official receipt or other documentation reasonably satisfactory to the Beneficiary evidencing such payment to such authority; and
(iii)    pay to the Beneficiary such additional amount or amounts as is necessary to ensure that the net amount actually received by the Beneficiary (including with respect to amounts paid pursuant to this Guaranty) will equal the full amount the Beneficiary would have received had no such withholding or deduction been required.
Moreover, if any Taxes (other than Taxes on the overall net income of the Beneficiary) are directly asserted against the Beneficiary with respect to any payment received or deemed to be received by the Beneficiary hereunder or under the Financing Agreement, the Beneficiary may pay such Taxes and the Guarantor will reimburse the Beneficiary, for such amounts and will promptly pay such additional amounts (including any penalties, interest or expenses) as are necessary in order that the net amount retained by the Beneficiary after the payment of such Taxes (including any Taxes on such additional amounts) shall equal the amount the Beneficiary would have retained had no such Taxes been asserted.
If the Guarantor fails to pay any Taxes when due to the appropriate taxing authority or fails to remit to the Beneficiary the required receipts or other required documentary evidence, the Guarantor shall indemnify the Beneficiary for any incremental Taxes, interest, penalties or other losses that may become payable by the Beneficiary as a result of any such failure.
Without prejudice to the survival of any other agreement of the Guarantor hereunder or under the Financing Agreement, the agreements and obligations of the Guarantor contained in this section shall survive the payment in full of the Guaranteed Obligations.
(d)    So long as any of the Guaranteed Obligations remain outstanding, the Guarantor will maintain its corporate existence and will not merge or consolidate with any other corporation nor dissolve or otherwise sell or dispose of all or substantially all of its assets, unless (i) the Guarantor obtains the prior written consent of the Beneficiary for those purposes, and (ii) the successor or transferee corporation (if other than the Guarantor) shall expressly and unconditionally assume, in a written instrument delivered to the Beneficiary, the punctual

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performance and observance of all covenants, conditions and obligations of this Guaranty to be performed by the Guarantor.
Section 5. Binding Effect. This Guarantee shall be binding upon the Guarantor, its successors and assigns. The Guarantor may not assign its rights nor delegate its obligations under this Guarantee in whole or in part without the prior written consent of the Beneficiary, and any purported assignment or delegation without such prior written consent shall be void.
Section 6. Severability. Any provision of this Guaranty that is prohibited or unenforceable in any jurisdiction shall, as to such jurisdiction, be ineffective to the extent of such prohibition or unenforceability without invalidating the remaining provisions hereof, and any such prohibition or unenforceability in any jurisdiction shall not invalidate or render unenforceable such provision in any other jurisdiction. To the extent permitted by applicable law, the Guarantor hereby waives any provision of law that renders any provisions hereof prohibited or unenforceable in any respect.
Section 7. Notices. Any notice to the Guarantor or Beneficiary hereunder and any copy to the Guarantor of any notice delivered by the Beneficiary to the Primary Obligor under the Financing Documents shall be in writing and mailed, postage prepaid, or sent by facsimile transmission to the following address and person or to such other address or person's attention as the Guarantor or Beneficiary shall notify each other from time to time.
Guarantor:
Amyris, Inc.
5885 Hollis Street, Suite 100
Emeryville, CA 94608
Attn.:    General Counsel and Corporate Secretary

Beneficiary:
NOSSA CAIXA DESENVOLVIMENTO - AGÊNCIA DE FOMENTO DO ESTADO DE SÃO PAULO S.A.
Rua da Consolação, nº 371 - Consolação
São Paulo - SP - Brazil - CEP: 01301-000
Attn.: Legal Department

Primary Obligor:
Amyris Brasil Ltda.
R. James Clerk Maxwell, 315 - Condomínio Techno Park
Campinas, SP, Brazil 13069-380
Attn.:    Chief Financial Officer

Any notice addressed as provided above shall be deemed delivered on the date of its receipt, duly evidenced by a receipt signed by the party to which it was delivered if delivered by hand or, in the case of facsimile transmission or mail, by a receipt notice. Any notice given in accordance with this provision shall not affect the obligations of the Guarantor under this Guarantee incurred before any termination date stated in the notice.

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Section 8. Governing Law and Jurisdiction. THIS GUARANTEE WILL BE GOVERNED BY AND CONSTRUED IN ACCORDANCE WITH THE LAWS OF THE STATE OF NEW YORK, WITHOUT REFERENCE TO CHOICE OF LAW DOCTRINE (OTHER THAN SECTIONS 5-1401 AND 5-1402 OF THE NEW YORK GENERAL OBLIGATIONS LAWS, WHICH SHALL APPLY HERETO). THE GUARANTOR IRREVOCABLY SUBMITS TO THE NON-EXCLUSIVE JURISDICTION OF ANY STATE OR FEDERAL COURT SITTING IN THE CITY OF NEW YORK TO ENFORCE OBLIGATIONS UNDER THIS GUARANTEE, AND WAIVE ANY OBJECTION BASED UPON PERSONAL JURISDICTION, IMPROPER VENUE, OR FORUM NON CONVEINENS WITH RESPECT TO, THESE COURTS.
The Guarantor further submits, for the purpose of any such suit, action, proceeding or judgment brought or rendered against it, to the appropriate courts of the jurisdiction of its domicile. Final judgment against the Guarantor in any such suit, action or proceeding shall be conclusive and may be enforced in any other jurisdiction without further review on the merits, including in Brazil, by suit on the judgment, a certified or exemplified copy of which shall be conclusive evidence of the judgment, or in any matter provided by law.
WAIVERS OF JURY TRIAL. EACH PARTY HERETO HEREBY IRREVOCABLY WAIVES, TO THE FULLEST EXTENT PERMITTED BY APPLICABLE LAW, ANY RIGHT IT MAY HAVE TO A TRIAL BY JURY IN ANY LEGAL PROCEEDING DIRECTLY OR INDIRECTLY ARISING OUT OF OR RELATING TO THIS GUARANTY OR THE TRANSACTIONS CONTEMPLATED HEREBY (WHETHER BASED ON CONTRACT, TORT OR ANY OTHER THEORY).
Section 9. Process Agent. (a) For the purposes of this Guarantee, the Guarantor hereby agrees that service of all writs, process and summonses in any suit, action or proceeding brought under this Guarantee may be made upon Corporation Service Company (CSC), 1180 Avenue of the Americas, Suite 210, New York, NY 10036 (the “ Process Agent ”), and the Guarantor hereby confirms and agrees that the Process Agent has been duly and irrevocably appointed as its agent and true and lawful attorney-in-fact in its name, place and stead to accept such service of any and all such writs, process and summonses, and agrees that the failure of the Process Agent to give any notice of any such service of process to the Guarantor shall not impair or affect the validity of such service or of any judgment based thereon.
(b) The Guarantor hereby irrevocably appoints and constitutes Amyris Brasil Ltda. as its attorney-in-fact, until the full and final payment, discharge and satisfaction of the Guaranteed Obligations, with powers to receive service of legal processes, notifications and subpoenas, in relation to any judicial or extrajudicial proceedings that may be brought against the Guarantor by the Beneficiary in Brazil in connection with this Guarantee and may include the performance of all the acts required for the good and faithful performance of this appointment, and agrees that failure by an attorney-in-fact to notify the Guarantor of the process, notification or subpoena will not invalidate the proceedings concerned.
Section 10. Amendment. This Guarantee shall not be amended, supplemented or otherwise modified except by a writing signed by both the Guarantor and the Beneficiary. No failure or delay of the Beneficiary in exercising any power or right hereunder shall operate as a

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waiver thereof, nor shall any single or partial exercise of any such right or power, or any abandonment or discontinuance of steps to enforce such a right or power, preclude any other or further exercise thereof or the exercise of any other right or power. The rights and remedies of the Beneficiary hereunder and under the Financing Documents are cumulative and are not exclusive of any rights or remedies that it would otherwise have. A waiver or consent shall be effective only in the specific instance and for the purpose for which given. No notice or demand on the Guarantor in any case shall entitle the Guarantor to any other further notice or demand in similar or other circumstances.
Agreed by:
Amyris, Inc.
By /s/ John Melo    
Name: John Melo
Title: President and CEO

Amyris Brasil Ltda.
By /s/ Paulo Diniz /s/ Felipe M. Caram    
Name: Paulo Diniz Felipe M. Caram
Title: Presidente


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ACKNOWLEDGMENT

State of California
County of Alameda

On June 7, 2012 before me, Dominic Lim, Notary Public personally appeared John Melo, who proved to me on the basis of satisfactory evidence to be the person(s) whose name(s) is/are subscribed to the within instrument and acknowledged to me that he/she/they executed the same in his/her/their authorized capacity(ies), and that by his/her/their signature(s) on the instrument the person(s), or the entity upon behalf of which the person(s) acted, executed the instrument.

I certify under PENALTY OF PERJURY under the laws of the State of California that the foregoing paragraph is true and correct.

WITNESS my hand and official seal.

Signature /s/ Dominic Lim     (seal)



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FINAL
CORPORATE GUARANTEE (Amyris)
GUARANTEE (as the same may be amended, supplemented or otherwise modified from time to time, the “ Guarantee ”), dated July 13, 2012 of Amyris, Inc., a corporation organized under the laws of the State of Delaware (the “ Guarantor ”) in favor of Banco PINE S.A., its successors and assigns (the “ Beneficiary ”).
WHEREAS , Amyris Brasil Ltda. a sociedade limitada formed under the laws of the Federative Republic of Brazil, (the “ Primary Obligor ”) has entered into the CCB - Cédula de Crédito Bancário dated July 13, 2012 (as amended, modified and supplemented from time to time, the “ Financing Agreement ”), with the Beneficiary, under which the Beneficiary has agreed to provide to the Primary Obligor credit in Brazilian Reais in the amount of R$ 22,000,000.00, for the development of an industrial farnesene producing unit in Brotas, State of São Paulo, subject to the conditions provided therein;
WHEREAS , in consideration of all transactions to which the Guarantee relates already entered into and to be entered into after the date hereof under the Financin g Agreement, and in return for substantial direct and indirect benefits to the Guarantor, the Guarantor has agreed to guarantee the payment of all amounts owed from time to time, and performance from time to time, due by the Primary Obligor under the Financing Agreement; and
WHEREAS , the Beneficiary also has the benefit of a security interest over machinery and equipment of the Primary Obligor pursuant to Quadro 6.2 of the Financing Agreement and any other security interests set out therein or in ancillary agreements (as amended, modified and supplemented from time to time, the “ Collateral ,” and together with the Financing Agreement, the “Financing Documents”).
NOW, THEREFORE, the Guarantor hereby agrees:
Section 1. The Guarantee . (a) From and after the date hereof, the Guarantor hereby irrevocably guarantees to the Beneficiary the payment of all present and future amounts (whether absolute or contingent, and whether for principal, interest, scheduled payments, termination amounts, fees, breakage costs, expenses, indemnification, contractual penalty, interest on deferred payments, or otherwise) owing by the Primary Obligor under or in respect of the Financing Agreement or any other Financing Documents, as and when such amounts become due and payable, whether at their scheduled due dates, upon acceleration, termination or otherwise (or would otherwise be owing, due or payable under the Financing Agreement but for the commencement of any bankruptcy, insolvency or similar proceeding in respect of the Primary Obligor) (such obligations, the “ Payment Obligations ”) and the performance of all delivery and other obligations of the Primary Obligor under the Financing Agreement or any other Financing Documents in accordance with the terms of the Financing Agreement or any other Financing Documents (the “ Performance Obligations ” and, together with the Payment Obligations, the “ Guaranteed Obligations ”). The Beneficiary shall have the option to demand payment of the Guaranteed Obligations from the Guarantor in U.S. Dollars or Brazilian Reais.
This is a guarantee of payment and performance, and not merely of collection. The Guarantor further agrees to pay all costs, fees and expenses (including, without limitation, fees of

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outside counsel) incurred by the Beneficiary in connection with enforcing or exercising rights under this Guarantee or arising from a breach by the Guarantor of the provisions hereof or any misrepresentation made by the Guarantor herein.
(b)    In no event shall the Beneficiary be obligated to take any action, obtain any judgment or file any claim prior to enforcing this Guarantee. Upon failure of the Primary Obligor punctually to pay or perform any Guaranteed Obligations, the Guarantor agrees promptly to pay or perform or cause to be paid or performed such Guaranteed Obligations. The rights, powers, remedies and privileges provided in this Guarantee are cumulative and not exclusive of any rights, powers, remedies and privileges provided by any other agreement or by law.
(c)    The Guarantor hereby agrees that this is an absolute and unconditional, continuing and unlimited guarantee.
(d)    The Guarantor hereby waives any claims relating to, and permits, as applicable:
(1) the invalidity, irregularity or unenforceability of the Financing Agreement or this Guarantee or any other Financing Documents or any other agreement related to the Financing Agreement or this Guarantee or any other Financing Documents;
(2) the lack of authority of Primary Obligor to execute or deliver the Financing Agreement or any other Financing Documents;
(3) any change in the time, manner or place of payment of, or in any other term of, or amendment to the Financing Agreement or any other Financing Documents;
(4) any change in amount, nature or otherwise, or discharge in connection with the Collateral;
(5) any waiver or consent by the Beneficiary with respect to any provisions of the Financing Agreement or any other Financing Documents or any compromise or release of any of the obligations thereunder;
(6) the absence of any action to enforce the Financing Agreement or any other Financing Documents, to recover any judgment against the Primary Obligor or to enforce a judgment against the Primary Obligor under the Financing Agreement or any other Financing Documents;
(7) the occurrence of any event of default or potential event of default under the Financing Agreement or any other Financing Documents;
(8) the existence of any bankruptcy, insolvency, reorganization or similar proceedings involving the Primary Obligor or its assets;
(9) other than payment of any amounts due hereunder, any setoff, counterclaim, or defense of any kind or nature which may be available to or asserted by the Guarantor or the Primary Obligor against the Beneficiary or any of its affiliates;

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(10) any impairment, taking, furnishing, exchange or release of, or failure to perfect or obtain protection of the Collateral or any other security interest in, collateral securing the Financing Agreement or any other obligation of the Primary Obligor;
(11) any change in the laws, rules or regulations of any jurisdiction;
(12) any present or future action of any governmental authority or court amending, varying, reducing or otherwise affecting, or purporting to amend, vary, reduce or otherwise affect, any of the obligations of the Primary Obligor under the Financing Agreement or any other Financing Documents or of Guarantor under this Guarantee;
(13) any claim as to the validity, regularity or enforceability of the subrogation rights provided in Section 3 below;
(14) any other circumstance (other than payment or performance) which might otherwise constitute a legal or equitable discharge or defense of a guarantor generally; or

(15) any change in the corporate existence, structure or ownership of the Primary Obligor, or any release or discharge of the Guaranteed Obligations.
(e)    The Guarantor hereby further waives diligence, presentment, demand on the Primary Obligor for payment or otherwise, filing of claims, requirement of a prior proceeding against the Primary Obligor and protest or notice. If at any time (including any time after termination or expiration of this Guarantee) payment under the Financing Agreement or any other Financing Documents is rescinded or must be otherwise restored or returned by the Beneficiary upon the insolvency, bankruptcy or reorganization of the Primary Obligor or the Guarantor or otherwise, the Guarantor's obligations hereunder with respect to such payment shall be reinstated upon such restoration or return being made by the Beneficiary, all as though such payment had not been made.
(f)    The Guarantor hereby agrees that, absent manifest error, the internal records of the Beneficiary setting forth the outstanding amount or the status of the Guaranteed Obligations are binding and conclusive proof of the amounts owed, or performance due, under the Financing Agreement and any other Financing Documents.
(g)    The Guarantor shall remain liable for the Guaranteed Obligations until the Guaranteed Obligations are irrevocably paid in full in accordance with this Guarantee and with the Financing Agreement, and nothing except irrevocable payment in full of all Guaranteed Obligations in accordance with this Guarantee and with the Financing Agreement shall release the Guarantor from its obligations under this Guarantee.
(h)    The Beneficiary shall have no obligation to disclose or discuss with the Guarantor their assessment, or any assessment by any other person, of the financial or other condition of the Primary Obligor; the Beneficiary shall have no obligation to investigate the financial or other condition of the Primary Obligor; the Guarantor has adequate means to obtain information from the Primary Obligor on a continuing basis concerning the financial and other condition of the Primary Obligor and its ability to perform its obligations and discharge its liabilities as they

3



become due; and the Guarantor assumes full responsibility for being and keeping informed of the financial and other condition of the Primary Obligor and of all circumstances bearing upon the risk of nonpayment of the Guaranteed Obligations to the extent the Guarantor desires to be kept so informed.
(i)    The Beneficiary may enforce this Guarantee upon the occurrence and during the continuance of a breach by the Primary Obligor of any of its obligations under the Financing Documents, notwithstanding the existence of any dispute between the Primary Obligor and the Beneficiary or any other party with respect to the existence of such breach or any other matter.
(j)    The Beneficiary may, at its election, foreclose on any security held by it in one or more judicial or nonjudicial sales, accept an assignment of any such security in lieu of foreclosure, compromise or adjust any part of the Guaranteed Obligations, make any other accommodation with the Primary Obligor or any other guarantor or exercise any other right or remedy available to it against the Primary Obligor, without affecting or impairing in any way the liability of the Guarantor hereunder except to the extent the Guaranteed Obligations then due and owing have been fully paid.
Section 2. Representations and Warranties. The Guarantor represents and warrants to the Beneficiary on the date hereof and, except as otherwise indicated, during the duration of this Guarantee that:
(a)    it has reviewed and is familiar with the terms of the Financing Documents;
(b)    it is duly organized and validly existing under the laws of the jurisdiction of its organization and has full power and legal right to execute and deliver this Guarantee and to perform the provisions of this Guarantee on its part to be performed;
(c)    its execution, delivery and performance of this Guarantee have been and remain duly authorized by all necessary organizational action and do not contravene any provision of its certificate of incorporation or by-laws, or any law, regulation or rule applicable to it or contractual restriction binding on it or its assets;
(d)    all consents, authorizations, approvals and clearances (including, without limitation, any necessary exchange control approval) and notifications, reports and registrations requisite for the due execution, delivery and performance of this Guarantee have been obtained from or, as the case may be, filed with the relevant governmental authorities having jurisdiction and remain in full force and effect and all conditions thereof have been duly complied with and no other action by, and no notice to, or filing with, any governmental authority having jurisdiction is required for such execution, delivery or performance;
(e)    this Guarantee is the valid and binding and enforceable obligation of the Guarantor;
(f)    the Guarantor and a wholly-owned subsidiary of Guarantor, together, own all the equity interest in the Primary Obligor and Guarantor acknowledges that it will receive substantial direct and indirect benefits from the transactions contemplated by the Financing

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Agreement and that its waivers of suretyship and other defenses are knowingly made in contemplation of such benefits;
(g)    on the date hereof and on the date of each disbursement under the Financing Agreement, after giving effect to this Guarantee, the aggregate fair saleable value of all of the Guarantor's property, at fair valuation, will be greater than the sum of all the Guarantor's liabilities of any nature, including without limitation contingent and unmatured debts or claims (“ Liabilities ”);
(h)    it has not transferred, concealed or removed any of its property with the intent to hinder, delay or defraud its creditors, nor is it now making this Guarantee with intent to hinder, delay or defraud its creditors;
(i)    on the date hereof and on the date of each disbursement under the Financing Agreement, after giving effect to this Guarantee, the value of its remaining assets is not unreasonably small in relation to its business as contemplated thereon or with respect to any transaction contemplated or undertaken thereafter;
(j)    on the date hereof and on the date of each disbursement under the Financing Agreement, it has not incurred and does not intend to incur, or believe (or reasonably believe) that it will incur Liabilities beyond its ability to pay as such Liabilities mature;
(k)    it has satisfied in full any final judgment against it in an action or suit for money damages which judgment results from an action or suit pending against it on or prior to the date hereof and there is no action or suit for money damages pending against it on or prior to the date hereof;
(l)    there are no other proceedings pending or, to the knowledge of the Guarantor, threatened against the Guarantor, at law or in equity, which, individually or in the aggregate, if adversely determined, would materially adversely affect the financial condition of the Guarantor or materially impair the Guarantor's ability to perform its obligations under this Guarantee;
(m)     none of its controlling shareholders, executive officers, members of its board of directors and their respective legal representatives, nor any of their family members or affiliates are politically exposed persons. For the purpose of this paragraph a “politically exposed person” means a person who is or has been entrusted in the last five years, in Brazil or in any other jurisdiction or territory, with any prominent public function, job or position, including, without limitation, head of state or government, high-ranking political appointments or elected politicians, high-ranking civil service positions, high-ranking judicial or military posts and chief of any corporation owned by a government, a governmental agency or political parties. Individuals in middle-ranking or more junior positions within the foregoing categories are excluded from the definition of “politically exposed persons”; and
(n)    none of its controlling shareholders, executive officers, managers, directors and their affiliates are subject to any financial sanctions of the United Nations

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Organization - UN, nor are they included in any financial sanctions lists in connection with terrorism or money laundering.
Section 3. Subrogation of Rights. By accepting this Guarantee and entering into the Financing Agreement, the Guarantor shall be subrogated to all rights of the Beneficiary against the Primary Obligor in respect of any amounts paid or performance by the Guarantor pursuant to this Guarantee, provided that the Guarantor shall be entitled to enforce or to receive any payment or performance arising out of or based upon such right of subrogation only when all amounts payable and all performance to be effected by the Primary Obligor under the Financing Agreement and the other Financing Documents have been paid and performed and the Financing Agreement has been terminated. The Guarantor agrees that it will not take any action against or in respect of the Primary Obligor relating to any payment or performance made by the Guarantor under this Guarantee until such time as the Guaranteed Obligations shall have been paid and performed in full and the Financing Agreement has been terminated.
Section 4. Covenants. (a)    So long as any Guaranteed Obligations remain outstanding or any Financing Documents remain in effect, the Guarantor shall not, without the prior written consent of the Beneficiary, commence or join with, or take any action in furtherance of, any other person in commencing any bankruptcy proceeding of or against Primary Obligor. The obligations of the Guarantor under this Guarantee shall not be reduced, limited, impaired, discharged, deferred, suspended or terminated by any bankruptcy proceeding of or against the Primary Obligor or by any defense that the Primary Obligor may have by reason of any order, decree or decision of any court or administrative body resulting from or relating to any such bankruptcy proceeding or the existence of such bankruptcy proceeding.
(b)    The Guarantor hereby agrees that until such time as all of the Guaranteed Obligations shall be paid and performed in full, the Subordinated Indebtedness (as hereinafter defined) is and shall be expressly subordinated, to the extent and in the manner hereinafter set forth, in right of payment to the prior payment of the Guaranteed Obligations.
The term "Subordinated Indebtedness" shall mean, at any time, the then outstanding aggregate principal amount of all indebtedness of the Primary Obligor to the Guarantor in respect of borrowed money, fees, royalties or other advance or arrangement (including any subrogation rights with respect to this Guaranty), all accrued and unpaid interest and premium, if any, thereon and all expenses incurred by and all indemnities payable to the Guarantor pursuant to any agreement between the Primary Obligor and the Guarantor in respect of any such indebtedness or otherwise.
Upon the happening of any breach by the Primary Obligor under the Financing Documents, unless and until such breach shall have been remedied or waived, no direct or indirect payment (in cash, property or securities or by set-off or otherwise) shall be made or agreed to be made on account of the Subordinated Indebtedness and the Guarantor shall not demand, collect or receive any payment on account of the Subordinated Indebtedness.
(c)    All payments made or deemed made by the Guarantor hereunder or under the Financing Agreement shall be made free and clear of, and without deduction for any present or future income, excise, stamp or franchise taxes and other taxes, fees, duties, withholdings or

6



other charges of any nature whatsoever imposed by any taxing authority (such items being herein referred to as “Taxes”). In the event that any withholding or deduction from any payment to be made or deemed to be made by the Guarantor hereunder or under the Financing Agreement is required in respect of any Taxes pursuant to any applicable law, rule, regulation, then the Guarantor will:
(i)    pay directly to the relevant authority the full amount required to be so withheld or deducted;
(ii)    promptly forward to the Beneficiary an official receipt or other documentation reasonably satisfactory to the Beneficiary evidencing such payment to such authority; and
(iii)    pay to the Beneficiary such additional amount or amounts as is necessary to ensure that the net amount actually received by the Beneficiary (including with respect to amounts paid pursuant to this Guaranty) will equal the full amount the Beneficiary would have received had no such withholding or deduction been required.
Moreover, if any Taxes (other than Taxes on the overall net income of the Beneficiary) are directly asserted against the Beneficiary with respect to any payment received or deemed to be received by the Beneficiary hereunder or under the Financing Agreement, the Beneficiary may pay such Taxes and the Guarantor will reimburse the Beneficiary, for such amounts and will promptly pay such additional amounts (including any penalties, interest or expenses) as are necessary in order that the net amount retained by the Beneficiary after the payment of such Taxes (including any Taxes on such additional amounts) shall equal the amount the Beneficiary would have retained had no such Taxes been asserted.
If the Guarantor fails to pay any Taxes when due to the appropriate taxing authority or fails to remit to the Beneficiary the required receipts or other required documentary evidence, the Guarantor shall indemnify the Beneficiary for any incremental Taxes, interest, penalties or other losses that may become payable by the Beneficiary as a result of any such failure.
Without prejudice to the survival of any other agreement of the Guarantor hereunder or under the Financing Agreement, the agreements and obligations of the Guarantor contained in this section shall survive the payment in full of the Guaranteed Obligations.
(d)    So long as any of the Guaranteed Obligations remain outstanding, the Guarantor will maintain its corporate existence and will not merge or consolidate with any other corporation nor dissolve or otherwise sell or dispose of all or substantially all of its assets, unless (i) the Guarantor obtains the prior written consent of the Beneficiary for those purposes, and (ii) the successor or transferee corporation (if other than the Guarantor) shall expressly and unconditionally assume, in a written instrument delivered to the Beneficiary, the punctual performance and observance of all covenants, conditions and obligations of this Guaranty to be performed by the Guarantor.

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Section 5. Binding Effect. This Guarantee shall be binding upon the Guarantor, its successors and assigns. The Guarantor may not assign its rights nor delegate its obligations under this Guarantee in whole or in part without the prior written consent of the Beneficiary, and any purported assignment or delegation without such prior written consent shall be void.
Section 6. Severability. Any provision of this Guaranty that is prohibited or unenforceable in any jurisdiction shall, as to such jurisdiction, be ineffective to the extent of such prohibition or unenforceability without invalidating the remaining provisions hereof, and any such prohibition or unenforceability in any jurisdiction shall not invalidate or render unenforceable such provision in any other jurisdiction. To the extent permitted by applicable law, the Guarantor hereby waives any provision of law that renders any provisions hereof prohibited or unenforceable in any respect.
Section 7. Notices. Any notice to the Guarantor or Beneficiary hereunder and any copy to the Guarantor of any notice delivered by the Beneficiary to the Primary Obligor under the Financing Documents shall be in writing and mailed, postage prepaid, or sent by facsimile transmission to the following address and person or to such other address or person's attention as the Guarantor or Beneficiary shall notify each other from time to time.
Guarantor:
Amyris, Inc.
5885 Hollis Street, Suite 100
Emeryville, CA 94608
Attn.: General Counsel and Corporate Secretary

Beneficiary:

Banco Pine S.A.
Av. Nações Unidas, 8.501 30 Andar
São Paulo -SP - Brazil CEP 05425-070
Attn.: Legal Department

Primary Obligor:
Amyris Brasil Ltda.
R. James Clerk Maxwell, 315 - Condomínio Techno Park
Campinas, SP, Brazil 13069-380
Attn.:    Chief Financial Officer

Any notice addressed as provided above shall be deemed delivered on the date of its receipt, duly evidenced by a receipt signed by the party to which it was delivered if delivered by hand or, in the case of facsimile transmission or mail, by a receipt notice. Any notice given in accordance with this provision shall not affect the obligations of the Guarantor under this Guarantee incurred before any termination date stated in the notice.
Section 8. Governing Law and Jurisdiction. THIS GUARANTEE WILL BE GOVERNED BY AND CONSTRUED IN ACCORDANCE WITH THE LAWS OF THE STATE OF NEW YORK, WITHOUT REFERENCE TO CHOICE OF LAW DOCTRINE

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(OTHER THAN SECTIONS 5-1401 AND 5-1402 OF THE NEW YORK GENERAL OBLIGATIONS LAWS, WHICH SHALL APPLY HERETO). THE GUARANTOR IRREVOCABLY SUBMITS TO THE NON-EXCLUSIVE JURISDICTION OF ANY STATE OR FEDERAL COURT SITTING IN THE CITY OF NEW YORK TO ENFORCE OBLIGATIONS UNDER THIS GUARANTEE, AND WAIVE ANY OBJECTION BASED UPON PERSONAL JURISDICTION, IMPROPER VENUE, OR FORUM NON CONVEINENS WITH RESPECT TO, THESE COURTS.
The Guarantor further submits, for the purpose of any such suit, action, proceeding or judgment brought or rendered against it, to the appropriate courts of the jurisdiction of its domicile. Final judgment against the Guarantor in any such suit, action or proceeding shall be conclusive and may be enforced in any other jurisdiction without further review on the merits, including in Brazil, by suit on the judgment, a certified or exemplified copy of which shall be conclusive evidence of the judgment, or in any matter provided by law.
WAIVERS OF JURY TRIAL. EACH PARTY HERETO HEREBY IRREVOCABLY WAIVES, TO THE FULLEST EXTENT PERMITTED BY APPLICABLE LAW, ANY RIGHT IT MAY HAVE TO A TRIAL BY JURY IN ANY LEGAL PROCEEDING DIRECTLY OR INDIRECTLY ARISING OUT OF OR RELATING TO THIS GUARANTY OR THE TRANSACTIONS CONTEMPLATED HEREBY (WHETHER BASED ON CONTRACT, TORT OR ANY OTHER THEORY).
Section 9. Process Agent. (a) For the purposes of this Guarantee, the Guarantor hereby agrees that service of all writs, process and summonses in any suit, action or proceeding brought under this Guarantee may be made upon Corporation Service Company (CSC), 1180 Avenue of the Americas, Suite 210, New York, NY 10036 (the “ Process Agent ”), and the Guarantor hereby confirms and agrees that the Process Agent has been duly and irrevocably appointed as its agent and true and lawful attorney-in-fact in its name, place and stead to accept such service of any and all such writs, process and summonses, and agrees that the failure of the Process Agent to give any notice of any such service of process to the Guarantor shall not impair or affect the validity of such service or of any judgment based thereon.
(b) The Guarantor hereby irrevocably appoints and constitutes Amyris Brasil Ltda. as its attorney-in-fact, until the full and final payment, discharge and satisfaction of the Guaranteed Obligations, with powers to receive service of legal processes, notifications and subpoenas, in relation to any judicial or extrajudicial proceedings that may be brought against the Guarantor by the Beneficiary in Brazil in connection with this Guarantee and may include the performance of all the acts required for the good and faithful performance of this appointment, and agrees that failure by an attorney-in-fact to notify the Guarantor of the process, notification or subpoena will not invalidate the proceedings concerned.
Section 10. Amendment. This Guarantee shall not be amended, supplemented or otherwise modified except by a writing signed by both the Guarantor and the Beneficiary. No failure or delay of the Beneficiary in exercising any power or right hereunder shall operate as a waiver thereof, nor shall any single or partial exercise of any such right or power, or any abandonment or discontinuance of steps to enforce such a right or power, preclude any other or further exercise thereof or the exercise of any other right or power. The rights and remedies of

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the Beneficiary hereunder and under the Financing Documents are cumulative and are not exclusive of any rights or remedies that it would otherwise have. A waiver or consent shall be effective only in the specific instance and for the purpose for which given. No notice or demand on the Guarantor in any case shall entitle the Guarantor to any other further notice or demand in similar or other circumstances.
Agreed by:
Amyris, Inc.
By /s/ John Melo    
Name: John Melo
Title: President and CEO

Amyris Brasil Ltda.
By /s/ Paulo Diniz /s/ Felipe M. Caram    
Name: Paulo Diniz Felipe M. Caram
Title: Presidente



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ACKNOWLEDGMENT

State of California
County of Alameda

On June 7, 2012 before me, Dominic Lim, Notary Public personally appeared John Melo, who proved to me on the basis of satisfactory evidence to be the person(s) whose name(s) is/are subscribed to the within instrument and acknowledged to me that he/she/they executed the same in his/her/their authorized capacity(ies), and that by his/her/their signature(s) on the instrument the person(s), or the entity upon behalf of which the person(s) acted, executed the instrument.

I certify under PENALTY OF PERJURY under the laws of the State of California that the foregoing paragraph is true and correct.

WITNESS my hand and official seal.

Signature /s/ Dominic Lim     (seal)


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CONFIDENTIAL TREATMENT REQUESTED. CERTAIN PORTIONS OF THIS DOCUMENT HAVE BEEN OMITTED PURSUANT TO A REQUEST FOR CONFIDENTIAL TREATMENT AND, WHERE APPLICABLE, HAVE BEEN MARKED WITH AN ASTERISK TO DENOTE WHERE OMISSIONS HAVE BEEN MADE. THE CONFIDENTIAL MATERIAL HAS BEEN FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION.



MASTER FRAMEWORK AGREEMENT
This MASTER FRAMEWORK AGREEMENT (this “Master Agreement ”) is made and entered into as of July 30, 2012, by and between Amyris, Inc., a Delaware corporation (“ Amyris ”), and Total Gas & Power USA, SAS, a société par actions simplifiée organized under the laws of the Republic of France (“ Total ”).
BACKGROUND
(A)
Amyris and Total are parties to that certain Technology License, Development, Research and Collaboration Agreement, entered into as of June 21, 2010, as amended by the First Amendment entered into as of November 23, 2011 (the “ Current Collaboration Agreement ”), which provides for certain research and development projects.
(B)
Contemporaneously with the execution of this Master Agreement, Amyris and Total will enter into the Second Amendment to the Current Collaboration Agreement (the “ Second Amendment ” and, the Current Collaboration Agreement, as so amended, the “ Collaboration Agreement ”) to conduct the Biofene Development Project as defined in the Second Amendment.
(C)
Contemporaneously with the execution of this Master Agreement, Amyris and Total will execute and deliver a Securities Purchase Agreement, dated as of the date hereof, by and among Amyris and Total (the “ SPA ”), pursuant to which Amyris will issue up to an aggregate principal amount of $105,000,000 of 1.5% Senior Unsecured Convertible Notes (the “ Notes ”).
(D)
Amyris and Total agree that this Master Agreement contains provisions applicable to the Collaboration Agreement, the SPA and the Notes (along with this Master Agreement, the “ Transaction Documents ”), and the transactions contemplated and governed by the Transaction Documents.
Agreement
The parties, intending to be legally bound, agree as follows:
ARTICLE 1
DEFINITIONS

SECTION 1.1.    In this Master Agreement, the following words and expressions shall have the meaning set forth in this Article 1.

(a) Affiliate means, with respect to any specified Person, any other Person (i) that owns or controls, directly or indirectly through one or more intermediaries, 50% or more of the voting rights of such specified Person; (ii) of which 50% or more of the voting rights are owned or controlled, directly or indirectly through one or more intermediaries, by such specified

1



Person; or (iii) of which 50% or more of the voting rights are owned or controlled, directly or indirectly through one or more intermediaries, by any Person contemplated by clause (i).

(b) Amyris JV Assets ” shall mean those JV Assets contributed or to be contributed to JVCO by Amyris pursuant to Section 3.2(b).

(c) Amyris License Agreement ” shall mean that certain license to be entered into by Amyris pursuant to Section 11.B of the Second Amendment.

(d) Biofene Development Project Plan ” has the meaning ascribed thereto in the Second Amendment.

(e) Business Day ” shall mean any day other than (i) Saturday or Sunday, (ii) any day that is a legal holiday pursuant to the laws of the State of New York or the Republic of France, or (iii) any day that is a day on which banking institutions located in New York, New York or Paris, France are authorized or required by law or other governmental action to close.

(f) Competition Law ” means any applicable laws that are designed or intended to regulate mergers or other business combinations or that are designed or intended to prohibit, restrict or regulate actions having the purpose or effect of monopolization or restraint of trade.

(g) Exchange Act ” means the Securities Exchange Act of 1934, as amended.

(h) Farnesane Diesel Product ” has the meaning ascribed thereto in the Second Amendment.

(i) Farnesane Jet Product ” has the meaning ascribed thereto in the Second Amendment.

(j) Larger Shareholder ” shall mean any “person” or “group” (as each such term is used in Rule 13d-3 and Rule 13d-5 of the Exchange Act) who shall “beneficially own” (as such term is defined in Rule 13d-3 and Rule 13d-5 under the Exchange Act), directly or indirectly, Voting Shares (measured by voting power rather than number of shares) representing a larger number of Voting Shares than the number of Voting Shares (measured by voting power rather than number of shares) “beneficially owned”, directly or indirectly, by Total and its Affiliates, in each case as reported on (or required to have been reported on to the extent any “executive officer” (as such term is defined in Rule 3b-7 under the Exchange Act) of Amyris has actual knowledge of the number of such “person” or “group's” Voting Shares) the most recent Schedule 13D or Schedule 13G or an amendment to any such Schedule filed with the Securities and Exchange Commission by any such “person” or “group” or by Total or any of its Affiliates or as otherwise publicly announced by any such “person” or “group” or by Total or any of its Affiliates.

(k) New Securities ” means any capital stock of Amyris, whether now authorized or not, and rights, options or warrants to purchase such capital stock, and securities of any type whatsoever that are, or may become, convertible into or exchangeable or exercisable for capital stock of Amyris; provided that the term “New Securities” does not include (i) securities

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of Amyris issued to employees, consultants, officers or directors of Amyris or any of its subsidiaries, or which have been reserved for issuance, pursuant to any employee stock option, stock purchase, stock bonus plan, or other similar stock agreement or arrangement approved by the Amyris Board of Directors, (ii) securities of Amyris issued in connection with any stock split, stock dividend or recapitalization of Amyris, (iii) securities of Amyris issued upon the conversion or exchange of convertible or exchangeable securities of Amyris that are outstanding as of the date of this Master Agreement or issuable upon conversion of the Securities, (iv) any right, option or warrant to acquire any security convertible into or exchangeable or exercisable for the securities excluded from the definition of New Securities pursuant to subclause (i) above if issued pursuant to any employee stock option, stock purchase, stock bonus plan or other similar stock agreement or arrangement approved by the Amyris Board of Directors or (v) securities of Amyris issued in connection with a merger or acquisition or other business combination transaction of the type described in Rule 145 under the Securities Act or in any similar type of merger or acquisition or other business combination transaction in which the sale of securities of Amyris will not be registered under the Securities Act, the primary purpose of which, in each case, is not to raise equity capital.

(l) Person ” shall mean any individual, corporation, limited liability company, partnership, joint venture, association, joint-stock company, trust, unincorporated organization or government or any agency or political subdivision thereof.

(m) Project Completion Date ” has the meaning ascribed thereto in Section 3.B of the Second Amendment.

(n) Second Closing ” has the meaning ascribed thereto in the SPA.

(o) Securities Act ” means the Securities Act of 1933, as amended.

(p) Third Closing ” has the meaning ascribed thereto in the SPA.

(q) Voting Shares ” of Amyris means capital shares or capital stock of Amyris which ordinarily has voting power for the election of directors (or persons performing similar functions) of Amyris, whether at all times or only so long as no senior class of securities has such voting power by reason of any contingency.

SECTION 1.2.     The following terms shall have the meanings defined in the Section indicated :
Defined Terms
Section
Acceptance Notice
5.1(b)
Agreement
Preamble
Amyris
Preamble
Amyris Sale Price
3.3(a)
Amyris Sale Price Notice
3.3(a)
Amyris Stockholder Approval
3.3(f)
Buy-Sell Election
3.3(b)
Brazil Business
4.1


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Defined Terms
Section
Buyout Election
3.3(b)
Collaboration Agreement
Recitals
Second Amendment
Recitals
Current Collaboration Agreement
Recitals
Jet Go Decision
2.2(b)
Fair Value
3.3
Final Go Decision Date
3.2(b)
Funding Deadlock Election
3.3(c)
Go Decision
2.2(b)
Go Decision Date
2.2(b)
Ground Floor Price
4.2(a)
Independent Account Firm
4.2(b)
Initial Plan and Budget
3.2(a)
Issuance Notice
5.1(a)
JV Assets
3.2(b)
JVCO
3.2(b)
License Agreements
3.2(b)
No‑Go Decision
2.2(a)
No‑Go Decision Date
2.2(a)
Notes
Recitals
Participation Exercise Period
5.1(a)
Pro Rata Share
5.1(a)
Purchase Price
3.3(c)
Shareholders' Agreement
3.1
SPA
Recitals
Total
Preamble
Transaction Documents
Recitals

ARTICLE 2
GO/NO-GO DECISIONS

SECTION 2.1.     Information .

(a) Biofene Development Project Plan Information .

(i) Amyris shall provide Total with the information described in Section 4.C of the Second Amendment and Exhibit D thereto.

(ii) Prior to the Project Completion Date Amyris and Total will share from time to time with the other party their respective inputs into the cost model for farnesene production.

(b) Preliminary Subsequent Closing Information .

(i) At least ninety days prior to the Second Closing and the Third Closing, as such terms are defined in the SPA, Amyris shall provide Total with an

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opportunity to ask questions of Amyris and Amyris shall provide to Total information to allow it to evaluate the financial risk inherent in making an investment in the Notes that may be purchased at the applicable Closing. Amyris shall use reasonable best efforts to promptly provide all requested information. In connection with the preceding sentence, Amyris shall provide Total reasonable access during normal business hours, upon reasonable notice, to any assets, properties, contracts, books, records and personnel of the Company and its subsidiaries as Total may reasonably request.

(ii) At least ninety days prior to the Second Closing and the Third Closing, Amyris shall provide Total with (x) a draft of an updated disclosure letter that would have been delivered pursuant to Article 3 of the SPA were the Second Closing or the Third Closing, as applicable, to occur on such date, which exceptions shall be deemed to be part of the representations and warranties that would have been made by Amyris pursuant to clause (y) of this paragraph, and (y) a statement to the effect that, were the Second Closing or the Third Closing, as applicable, to occur on such date, the representations and warranties that would have been made by Amyris in Section 3 of the SPA at such Second Closing or the Third Closing, as applicable, would have been true and correct in all material respects as of, and as if made as of, such Second Closing or the Third Closing, as applicable. Such draft disclosure letter and certificate shall be for informational purposes only and shall not have any effect under the SPA, shall not be relied on by Total in effecting the Second Closing or the Third Closing, as applicable, and shall not constitute disclosure furnished by or on behalf of Amyris to Total in connection with the offer, sale and purchase of Notes pursuant to the SPA. Only the disclosure letter delivered pursuant to Article 3 of the SPA and the certificates delivered pursuant to Article 6 of the SPA shall have any effect under the SPA, and only such disclosure letter and certificates should be relied on by Total in effecting the Second Closing or the Third Closing, as applicable.

(iii) This Section 2.1(b) shall cease to be of any force and effect following the occurrence of a No-Go Decision Date (as defined in Section 2.2(a) below).

SECTION 2.2.     Interim No‑Go Decisions and Final Go/No-Go Decision .

(a) Interim No-Go Decisions . Prior to each of June 30, 2013 and June 30, 2014, Total may notify Amyris in writing that it no longer wishes to participate in the Biofene Development Project Plan (a “ No-Go Decision ”). The No-Go Decision shall be effective thirty (30) calendar days following the date of such notice (the “ No-Go Decision Date ”). The effect of the occurrence of a No-Go Decision shall be as set forth in this Master Agreement, the Second Amendment, the SPA and the Notes. In the event Total shall not have notified Amyris of its decision to effect a No-Go Decision prior to June 30, 2013, Amyris and Total shall consummate the Second Closing pursuant to the SPA, subject to the satisfaction of the conditions to the Second Closing set forth in the SPA. In the event Total shall not have notified Amyris of its decision to effect a No-Go Decision prior to June 30, 2014, Amyris and Total shall consummate the Third Closing pursuant to the SPA, subject to the satisfaction of the conditions to the Third Closing set forth in the SPA.


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(b) Final Go/No-Go Decision Date : Within thirty calendar days following the earlier of (i) the Project Completion Date and (ii) December 31, 2016 (the “ Go Decision Date ”), Total shall notify Amyris in writing whether it wishes to (x) make a No‑Go Decision, which No-Go Decision shall have effects set forth in Section 2.2(a), (y) form the JVCO contemplated by and pursuant to Article 3 hereof (a “ Go Decision ”), or (z) make a No‑Go Decision on the Farnesane Diesel Product and to form JVCO contemplated by and pursuant to Article 3 hereof with respect to the Farnesane Jet Product only (“ Jet Go Decision ”). In the event that Total shall fail to notify Amyris of such election by the Go Decision Date, Total shall be deemed to have made a Go Decision. The effect of the occurrence of a Jet Go Decision shall be as set forth in this Master Agreement, the Second Amendment, the SPA and the Notes.

(c) Go Decision; Jet Go Decision. In the event that Total notifies Amyris that it has made a Go Decision, if not already created, Total and Amyris shall seek to form the JVCO pursuant to Article 3 hereof. In the event Total notifies Amyris that it has elected a Jet Go Decision, if not already created, Total and Amyris shall seek to form a JVCO pursuant to Article 3 hereof with respect to the Farnesane Jet Product only.

(d) Note Funding . If Total does not accept delivery of the Notes and to pay for the Notes at any Closing (as such term is defined in the SPA) pursuant to the SPA, either because of the failure of Amyris to satisfy a condition to any such Closing set forth in the SPA (which breach is not cured by Amyris within thirty days), or Total's breach of any such purchase obligation under the SPA (which breach is not cured by Total within thirty days), then Total shall be deemed to have delivered a No-Go Decision, which No-Go Decision shall have the effects set forth in Section 2.2(a).

SECTION 2.3.     Access to Information . Without limiting any other remedies that may be available for breach of this Article 2, the parties agree that the failure to provide any information, or any disagreement over the adequacy of the content or access to such information, required to be provided pursuant to this Article 2 shall not delay or extend any deadlines set forth herein.

ARTICLE 3
JOINT VENTURE

SECTION 3.1.     Finalization of Corporate Structure of Joint Venture .

(a) It is the expectation of the parties that the parties shall establish a joint venture entity no later than March 31, 2013 with the structure set forth in the license terms and principles previously agreed to by the parties.

(b) Not later than six months prior to the anticipated Project Completion Date, Amyris and Total shall negotiate in good faith to agree on a form of corporate structure for JVCO, which form will be a Dutch cooperative unless mutually agreed otherwise. Following the finalization of the corporate structure for the JVCO, Amyris and Total will engage in good faith negotiations to amend the form of Shareholders' Agreement in substantially the form as approved by the parties effective as of the date of this Master Agreement (the “ Shareholders' Agreement ”) only to reflect such agreed upon final corporate structure, while maintaining to the fullest extent possible the substantive provisions of the form of Shareholders' Agreement.


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SECTION 3.2.     Shareholders' Agreement .

(a) Not later than six months prior to the anticipated Project Completion Date, Amyris and Total shall engage in good faith negotiations to (i) agree as promptly as practicable upon a final form of Shareholders' Agreement, as agreed pursuant to Section 3.1 hereof, and (ii) to finalize and agree as promptly as practicable on a five-year plan pursuant to the Shareholders' Agreement and an initial budget pursuant to the Shareholders' Agreement (the “ Initial Plan and Budget ”). In connection with such good faith negotiations, including but not limited to the geographic scope,  the Initial Plan and Budget, and the amount of funding required thereunder, the parties agree to use their best efforts  and  good  faith:  (i) to  maximize the economic viability and value of the JVCO; and (ii) to reach agreement on JVCO terms as soon as reasonably practicable, regardless of differing opinions on valuation.

(b) Following final agreement between Amyris and Total on the matters set forth in section 3.2(a) above (the date of such agreement being the “ Final Go Decision Date ”), both Amyris and Total will (i) execute the Shareholders' Agreement and take all other actions necessary to form the joint venture entity contemplated thereby (“ JVCO ”), (ii) enter into the license agreements contemplated by the Shareholders' Agreement and the Second Amendment (collectively, the “ License Agreements ”), (iii) enter into the contribution agreements in the form to be attached to the Shareholders' Agreement, which contribution agreements will require Amyris and Total to contribute to JVCO (A) any contracts or agreements which specifically and solely relate to the Farnesane Diesel Products and Farnesane Jet Products as applicable, other than any such agreements entered into by Amyris which relate exclusively to the Brazil Business, and (B) such funding as may be agreed to in the Initial Budget pursuant to Section 3.2(a) (together, with the License Agreements, the “ JV Assets ”). The effect of the occurrence of the Final Go Decision Date shall be as set forth in this Master Agreement, the Second Amendment, the SPA and the Notes. It is the intention of the parties that JVCO shall be owned initially 50% by Total and 50% by Amyris, unless modified pursuant to Section 3.3(e) hereof, and the expected initial contributions of each party to JVCO shall be and are deemed to be for all purposes of equivalent value, regardless of any valuation of such contributions or any portion thereof, and each of Total G&P and Amyris shall be deemed to have been issued 50% of the equity interests in JVCO in respect thereof.  In no event shall either Amyris or Total be required to provide any additional capital, nor shall there be any adjustment of the equity interests in JVCO issued to either Amyris or Total, with respect to their initial capital contributions or any valuation thereof.

SECTION 3.3.     Deadlock .

(a) Within the 30 day period preceding the Go Decision Date, Total may make a No-Go Decision, which No-Go Decision shall have the effects set forth in Section 2.2(a).

(b) In the event (i) at any time within the 30 day period preceding the Go Decision Date the parties are unable to come to agreement on all matters set forth in Section 3.2 having used their best efforts and good faith pursuant to Section 3.2(a), or (ii) the parties have

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come to agreement on all matters set forth in Section 3.2 and Amyris indicates in writing that it is unwilling or unable to move forward with the formation of JVCO or to fund all or any portion of the funding required pursuant to Section 3.2(b), then at any time prior to the Final Go Decision Date Total may deliver a written notice to Amyris electing to initiate the buyout provisions of Section 3.3(b) (the “ Buyout Election ”).

(c) If Total shall deliver to Amyris a Buyout Election, to establish the price for the purchase of Amyris' interest in the potential JVCO, the parties shall determine the Fair Value of the proposed joint venture in accordance with Section 3.3(g) hereof. Such Fair Value determination shall be made assuming for the purposes of such determination that JVCO was formed pursuant to Section 3.2(b) above. Within 30 days following the date on which the Fair Value of the proposed JVCO is finally determined in accordance with Section 3.3(g) hereof, Amyris shall deliver to Total a written election (“ Deadlock Election ”) indicating either (i) that it elects to sell the Amyris JV Assets to Total in exchange for an amount equal to 50% of the Fair Value of the proposed JVCO as finally determined pursuant to Section 3.3(g) (the “ Purchase Price ”), (ii) that it accepts Total's last position with respect to the funding requirements of JVCO, and agrees to proceed with the formation of JVCO pursuant to Section 3.2 on the basis of such funding amount, or (iii) that it accepts Total's last position with respect to the funding requirements of JVCO, agrees to proceed with the formation of JVCO pursuant to Section 3.2 on the basis of such funding amount, but that it wishes to sell all or a portion of its initial 50% interest in JVCO to Total pursuant to Section 3.3(e) below. In the event that Amyris does not deliver such Default Election within 30 days following the date on which the Fair Value of the proposed JVCO is finally determined, then it shall be deemed to have elected to sell the Amyris JV Assets pursuant to subsection (i) above.

(d) If Amyris elects (or is deemed to have elected) to sell to Total its interest in the potential JVCO (including without limitation the Amyris JV Assets), Amyris and Total shall select, for consummation of the sale of the Amyris JV Assets to Total, a closing date not later than 60 days (or longer, if required to obtain any approval of Amyris' stockholders pursuant to Section 3.3(f) below or if any Competition Law so requires) after the delivery of the Deadlock Election (or its deemed delivery). At such closing to acquire 100% of Amyris's interest in the potential JVCO, (i) Total shall deliver the Purchase Price to Amyris by wire transfer to an account in the United States designated by Amyris and in such case Amyris shall have no further interest in the potential JVCO, (ii) Total shall contribute the Notes to Amyris, which Notes will be cancelled and terminated by Amyris and (iii) Amyris shall (A) enter into a license agreement with Total for the license of the intellectual property rights which would have been subject to the License Agreement to be entered into by Amyris at formation of JVCO, (B) deliver to Total such other documents as, in the mutual agreement of Amyris and Total, are necessary or appropriate to convey to Total the Amyris JV Assets, and (C) enter into an exclusivity agreement containing exclusivity provisions similar to exclusivity provisions Amyris would have been subject to had JVCO been formed; provided , that Amyris shall not be required to provide representations or warranties other than basic representations and warranties regarding its authority to enter into the sale documentation, the due execution and binding nature of its sale documentation, and that its participation in the sale will not contravene, or require a consent, waiver or approval pursuant to, any applicable law or pursuant to any agreement to which it is subject and other customary representations and warranties for an acquisition of this type agreed to by the parties. Subject to the approval requirements in Section 3.3(f), if applicable, each of the parties shall use its

8



reasonable best efforts to take, or cause to be taken, all appropriate action, and to do, or cause to be done, all things necessary, proper or advisable under applicable laws to consummate and make effective any such transfer of the Amyris JV Assets to Total, including, without limitation, using reasonable best efforts to obtain all licenses, permits, consents, approvals, authorizations, qualifications and orders of the competent governmental entities. Without limiting the generality of the foregoing, the parties shall, when required in order to effect any such transfer of the Amyris JV Assets to Total contemplated hereunder, make all necessary filings, and thereafter make any other required or appropriate submissions, under any Competition Law and shall supply as promptly as practicable to the appropriate governmental entity any additional information and documentary material that may be requested pursuant to any Competition Law.

(e) If Amyris elects to sell all or a portion, but less than all, of its potential 50% interest in JVCO to Total pursuant to Section 3.3(c)(iii) above, it shall set forth in its Deadlock Election what percentage of JVCO that it wishes to sell to Total (the “ Buyout Percentage ”). The parties shall then proceed to form JVCO pursuant to Section 3.2(b); provided, however, that (i) the initial ownership percentage of JVCO held by Amyris shall be 50% minus the Buyout Percentage and the initial ownership percentage of JVCO held by Total shall be 50% plus the Buyout Percentage, (ii) Total shall deliver an amount equal to the product of (A) the Fair Value of potential JVCO determined pursuant to Section 3.3(c) above and (B) the Buyout Percentage to Amyris by wire transfer to an account in the United States designated by Amyris. Amyris's obligations to fund any capital contributions of JVCO pursuant to the Initial Plan and Budget shall also be proportionately reduced to match its percentage ownership of JVCO.

(f) If the approval of the majority of the stockholders of Amyris is required in connection with any of the transactions contemplated by this Section 3.3 (the “ Amyris Stockholder Approva l”) pursuant to Section 271 of the Delaware General Corporation Law, then the consummation of any such transactions shall be subject to obtaining the Amyris Stockholder Approval. Amyris covenants to use reasonable best efforts to solicit and obtain as promptly as practicable the Amryis Stockholder Approval.

(g) For the purposes of this Master Agreement, “ Fair Value ” of the potential JVCO means the aggregate equity value of the potential JVCO (assuming for the purposes of such determination that JVCO was formed pursuant to Section 3.2(b) above, including, without limitation, assuming the cancellation of the Notes in connection with such formation) that a willing buyer would pay a willing seller in an arms'‑length transaction to acquire JVCO, assuming that JVCO was being sold in a manner designed to maximize bids, when neither the buyer nor the seller was acting under compulsion and when both have reasonable knowledge of the relevant facts, without any control premiums or illiquidity or minority interest discounts. Amyris and Total G&P shall negotiate in good faith for a period of 20 days from the date of the event giving rise to the need for a determination of Fair Value to try to determine the Fair Value of potential JVCO. If Amyris and Total G&P are unable to reach a mutual determination of Fair Value within such 20‑day period, each of Amyris and Total G&P shall promptly appoint (at its own expense) a qualified, recognized appraiser of international standing (such as, by way of example only, the valuation group of an international accounting firm or a global investment bank) with substantial experience in valuing companies with a size, organization, and assets similar to that of JVCO (each, an “ Advisor ”), and each such Advisor shall deliver a written opinion with supporting materials as to the Fair Value of potential JVCO (an “ Advisor's

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Report ”) to each of Amyris and Total G&P concurrently within 20 Business Days of its appointment (the “ Opinion Period ”).. If the Fair Value of potential JVCO determined by an Advisor is presented in such Advisor's Report as a range of values, then the Fair Value of potential JVCO for purposes of such Advisor's Report shall be deemed to be the arithmetic average of such range. If only one Advisor timely delivers its Advisor's Report, the value determined by such Advisor shall be deemed to be the Fair Value of potential JVCO for purposes hereof. If both of the Advisors timely deliver an Advisor's Report and if the difference between the Fair Values submitted by each Advisor equals 10% or less of the higher value, then the Fair Value of potential JVCO for purposes hereof shall be deemed to be the arithmetic average of the Fair Values submitted by such Advisors. If the difference between the two values is greater than 10% of the higher value, then Amyris and Total G&P shall negotiate in good faith for a period of 5 Business Days from the expiration of the Opinion Period to try to determine the Fair Value of potential JVCO. If, during such period, Amyris and Total G&P cannot agree on the Fair Value of potential JVCO, then they shall jointly select a third Advisor that has not been engaged by either of Amyris and Total G&P or their respective Affiliates in any capacity during the two‑year period preceding such date, which third Advisor shall be required to choose only one of the two previously‑submitted Fair Values and shall not be authorized to determine a new, third value. If Amyris and Total G&P cannot agree on the third Advisor, then their respective Advisors shall together be instructed to select as the third Advisor an Advisor that has not been engaged by either of Amyris and Total G&P or their respective Affiliates in any capacity during the six‑months period preceding such date. Neither Amyris nor Total G&P (or any Affiliate or representative of either Amyris or Total G&P) shall communicate unilaterally with the third Advisor. The third Advisor will be instructed to deliver to Amyris and Total G&P concurrently, within 15 Business Days of its appointment, an Advisor's Report selecting which of the two Fair Values submitted by the original two Advisors better approximates the Fair Value of potential JVCO. The value chosen by the third Advisor shall then be deemed to be the Fair Value of potential JVCO and will be non‑appealable, final and binding on the Parties for purposes hereof. The parties commit to provide the Advisors with complete and accurate information to allow the Advisors to accurately and independently estimate the Fair Value of the potential JVCO. This information shall include without limitation the materials used by each party to determine the Budget and the five year Plan and access to relevant representatives for interviews. The Advisors shall, in determining the Fair Value of potential JVCO, consider all material information resulting from such diligence and access, subject to the definition of “Fair Value” set forth herein. Each of Amyris and Total G&P shall bear the fees and expenses of its Advisor, and they shall split equally the fees and expenses of the third Advisor. Each Party shall use its respective reasonable efforts to assist in the determination of the Fair Value of potential JVCO, including providing any information reasonably required for such purpose.

(h) If Total does not pay the Purchase Price at the closing contemplated by Section 3.3(d) above, or the closing contemplated by Section 3.3(d) above does not occur within 60 days (or longer, if required to obtain any approval of Amyris' stockholders pursuant to Section 3.3(f) above or if any Competition Law so requires) after the final determination of the Purchase Price, then Amyris shall have the option to: (i) continue to require Total to purchase the Amyris JV Assets, plus interest thereon at a rate of 10% per annum; or (ii) purchase from Total the JV Assets owned by Total at a purchase price equal to the Purchase Price, in which event the parties shall effect the sale of the JV Assets held by Total to Amyris at a closing to be held in accordance with Section 3.3(d) above.


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(i) Notwithstanding anything in this Master Agreement to the contrary, Total shall have no obligation pursuant to this Article 3 to pay the Purchase Price, Amyris shall have no obligation pursuant to this Article 3 to sell to Total its interest in the potential JVCO, and neither Amyris nor Total shall have any obligation to consummate the transactions contemplated by this Article 3 if any required approval of Amyris' stockholders pursuant to Section 3.3(f) above has not been obtained within 60 days after mailing the proxy statement related to such approval, if any required approval of Competition Law has not been obtained, or if any waiting period under Competition Law shall not have expired or been terminated within 60 days (or such longer period as may be required for such approval, expiration or termination under such Competition Law) after the making of the applicable filing under such Competition Law.

ARTICLE 4
BRAZIL JET/DIESEL

SECTION 4.1.     Rights to Conduct the Brazil Business .

(a) For the purpose of this Section “ Brazil Business ” shall mean production and commercialization of Farnesane Diesel Products and Farnesane Jet Products within Brazil for commercialization solely in Brazil. The Brazil Business shall include the right to produce Farnesane Diesel Products and Farnesane Renewable Jet Products outside of Brazil for commercialization within Brazil, but shall exclude the right to produce Farnesane Diesel Products and Farnesane Jet Products within Brazil for commercialization outside of Brazil (it being understood that the commercialization of Farnesane Diesel Products and Farnesane Jet Products for use in vehicles which begin an international travel segment within Brazil and conclude such international travel segment outside of Brazil shall constitute commercialization of such products within Brazil).

(b) The parties acknowledge that it would be desirable for the Brazil Business be conducted by a single entity. Accordingly, (i) if the Brazil Business is acquired by JVCO pursuant to Section 4.2, JVCO shall be entitled to conduct the Brazil Business exclusively and independently of Amyris and Total, and (ii) if the Brazil Business is acquired by Total pursuant to Section 4.3, Total shall be entitled to conduct the Brazil Business exclusively and independently of Amyris and JVCO. If the Brazil Business is not acquired by JVCO or Total pursuant to the preceding sentence, the parties shall use reasonable best efforts to agree on a single entity to commercialize Farnesane Diesel Products and Farnesane Jet Products in Brazil, provided , that in the event the parties are unable to agree, Amyris shall be entitled to conduct the Brazil Business independently of Total and JVCO. Promptly following the making of a Go Decision or a Jet Go Decision pursuant to Section 2.2(b) hereof, Amyris commits to provide Total and JVCO with complete and accurate information to allow Total and JVCO to accurately and independently estimate the value of the Brazil Business. Amyris shall promptly provide all requested information. In connection with the preceding sentence, Amyris shall provide Total, JVCO, and their respective advisors with reasonable access during normal business hours, upon reasonable notice, to any assets, properties, contracts, books, records and personnel of the Brazil Business as Total may reasonably request. In the event Total shall exercise the Jet Go Decision, Amyris and Total shall work together in good faith to evaluate the feasibility of restructuring the Brazil Business to separate the assets of the Brazil Business related to the development, production and commercialization of Farnesane Diesel Products from the assets of the Brazil

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Business related to the development, production and commercialization of Farnesane Jet Products.

SECTION 4.2.     Contribution of Brazil Business to JVCO .

(a) If at the time JVCO is formed Amyris shall own [*] % of the capital stock of JVCO, then if Total delivers written notice to Amyris within [*]  days following the formation of JVCO that JVCO shall acquire the Brazil Business, the parties shall determine the Ground Floor Price pursuant to Section 4.2(b). If at the time JVCO is formed Amyris shall own [*] % of the capital stock of JVCO, then if Total delivers written notice to Amyris within [*]  days following the formation of JVCO that JVCO shall acquire the Brazil Business, [*] for the Brazil Business (the “ Brazil Business Sale Price ”). Within [*] days following determination of the Ground Floor Price or the Brazil Business Sale Price, as applicable, (i) Total shall transfer to JVCO an amount of readily available cash equal to its pro rata share (based on its pro rata ownership of JVCO) of the Ground Floor Price or the Brazil Business Sale Price, as applicable (which transfer shall not be a capital contribution or a shareholder loan and shall not change the pro rata ownership of JVCO), and (ii) Amyris will contribute the Brazil Business to JVCO in exchange for the payment by JVCO to Amyris of the Ground Floor Price or the Brazil Business Sale Price, as applicable, which contribution shall be effected by such documents as, in the mutual agreement of Total (on behalf of JVCO) and Amyris, are necessary or appropriate to convey the Brazil Business; provided , that Amyris shall be required to provide customary representations or warranties agreed to by the parties for this kind of transactions including basic representations and warranties regarding its authority to enter into the sale documentation, the due execution and binding nature of the sale documentation by Amyris, and that its participation in the sale will not contravene, or require a consent, waiver or approval pursuant to, any applicable law or pursuant to any agreement to which it is subject. If the Brazil Business is to be transferred to JVCO pursuant to the prior sentence, each of the parties shall use its reasonable best efforts to take, or cause to be taken, all appropriate action, and to do, or cause to be done, all things necessary, proper or advisable under applicable laws to consummate and make effective any such transfer of the Brazil Business to JVCO, including, without limitation, using reasonable best efforts to obtain all licenses, permits, consents, approvals, authorizations, qualifications and orders of the competent governmental entities. Without limiting the generality of the foregoing, the parties shall, when required in order to effect such transfer of the Brazil Business to JVCO, make all necessary filings, and thereafter make any other required or appropriate submissions, under any Competition Law and shall supply as promptly as practicable to the appropriate governmental entity any additional information and documentary material that may be requested pursuant to any Competition Law.

(b) For the purposes of this Section 4.2, “ Ground Floor Price ” means [*] , including, but not limited to, [*] ; provided , however , that if Amyris and Total are unable to agree upon such Ground Floor Price within [*]


[*] Certain portions denoted with an asterisk have been omitted and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested with respect to the omitted portions.


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days of Total's election to cause the Brazil Business to be acquired by JVCO, then either Amyris or Total may submit all matters that remain in dispute with respect to the determination of the Ground Floor Price to a mutually agreed independent “Big Four” accounting firm or an Advisor as defined in Section 3.3(g) (the “ Independent Accounting Firm ”). Within sixty days after such firm's selection, the Independent Accounting Firm shall make a final determination, binding on the parties hereto, of the appropriate amount of each disputed item submitted to the Independent Accounting Firm. With respect to each disputed item, such determination, if not in accordance with the position of either party, shall not be in excess of the higher, nor less than the lower, of the amounts advocated by the parties with respect to such disputed item. The cost of the Independent Accounting Firm's review and determination shall be borne in the same proportion as the aggregate amount of the disputed items that is unsuccessfully disputed by each (as determined by the Independent Accounting Firm) bears to the total amount of disputed items submitted to the Independent Accounting Firm. During the review by the Independent Accounting Firm, Amyris and its accountants will make available to the Independent Accounting Firm such information, books and records and work papers, as may be reasonably required by the Independent Accounting Firm to fulfill its obligations under this Section 4.2(b); provided , however , that the external auditors of Amyris shall not be obligated to make any work papers available to the Independent Accounting Firm or the Advisor except in accordance with such auditors's normal disclosure procedures and then only after such firm has signed a customary agreement relating to such access to work papers in form and substance reasonably acceptable to such auditors.

(c) In the event that Total exercises the Jet Go Decision, Amyris shall have no obligation to contribute any of the assets of the Brazil Business related to the development, production and commercialization of Farnesane Diesel Products, and Amyris shall have no obligation to contribute any of the assets of the Brazil Business related to the development, production and commercialization of Farnesane Jet Products unless Amyris and Total shall have concluded that it is reasonably feasible to restructure the Brazil Business to separate the assets of the Brazil Business related to the development, production and commercialization of Farnesane Diesel Products from the assets of the Brazil Business related to the development, production and commercialization of Farnesane Jet Products, in which event Total and Amyris shall seek to cause to be contributed to JVCO pursuant to this Section 4.2 only the assets of the Brazil Business related to the development, production and commercialization of Farnesane Jet Products.

SECTION 4.3.     Sale of Brazil Business to Total . If Total shall acquire the JV Assets of Amyris pursuant to Section 3.3(c)(i) above, then if Total delivers written notice to Amyris within [*]  days following such acquisition of JV Assets that Total shall acquire the Brazil Business, the parties shall negotiate in good faith to agree on the Brazil Business Sale Price. Within [*] days following determination of the Brazil Business Sale Price, Amyris will sell the Brazil Business to Total in exchange for the payment by Total to Amyris of the Brazil Business Sale Price, which sale shall be effected by such documents as, in the mutual agreement of Total and Amyris, are necessary or appropriate to convey the Brazil Business. If the Brazil Business is to be sold to Total pursuant to the prior sentence, each of the parties shall use its reasonable best efforts to take, or cause to be taken, all appropriate action, and to do, or cause to be done, all things necessary, proper or advisable under applicable laws to consummate and make effective any such transfer of the Brazil Business to Total, including,


[*] Certain portions denoted with an asterisk have been omitted and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested with respect to the omitted portions.


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without limitation, using reasonable best efforts to obtain all licenses, permits, consents, approvals, authorizations, qualifications and orders of the competent governmental entities. Without limiting the generality of the foregoing, the parties shall, when required in order to effect such transfer of the Brazil Business to Total, make all necessary filings, and thereafter make any other required or appropriate submissions, under any Competition Law and shall supply as promptly as practicable to the appropriate governmental entity any additional information and documentary material that may be requested pursuant to any Competition Law. Customary representations and warranties for an acquisition of this type will be provided by Amyris.

ARTICLE 5
PRO RATA RIGHTS

SECTION 5.1.     Right to Purchase New Securities .

(a) With respect to any proposed issuance of New Securities to any third party (i) on or prior to December 31, 2013 or (ii) on or after January 1, 2014, when there shall then exist a Larger Shareholder and the No-Go Decision Date shall not have occurred and for so long as the Notes are outstanding, Amyris shall offer to Total by written notice (the “ Issuance Notice ”) the right, for a period of not less than 15 days (or such longer period as may be provided to any other investor with similar rights to purchase new securities) following delivery of such Issuance Notice (the “ Participation Exercise Period ”), to subscribe for, at a subscription price per New Security equal to the subscription price for which the New Securities are proposed to be issued to such third party and otherwise upon the terms specified in the Issuance Notice, up to that number of New Securities necessary to permit Total to maintain its pro rata ownership of Amyris following such issuance that it had immediately prior to such issuance (calculated on an as-converted basis, and excluding any securities that are not then convertible) (“ Pro Rata Share ”) in accordance with paragraph (b) below. The New Securities to be offered to Total pursuant to the Issuance Notice shall be, at the sole discretion of Amyris, either in lieu of the New Securities proposed to be issued to such third party or in addition to the New Securities proposed to be issued to such third party; provided that such offer shall in each case provide that Total shall be able to maintain its Pro Rata Share. The Issuance Notice shall include the aggregate number and type of New Securities proposed to be issued, the price per New Security and any other material terms of the proposed issuance to such third party; provided , however , if the sale price at which Amyris proposes to issue, deliver or sell any New Securities is to be paid with consideration other than cash, then the purchase price at which Total may acquire its portion of such New Securities will be equal in value (as determined in good faith by the Amyris Board of Directors) but payable entirely in either cash or Securities (as defined in the SPA) as provided below. Total's rights under this Section 4.1(a) shall terminate if not exercised within the Participation Exercise Period.

(b) Total (or a Permitted Transferee (as defined in the SPA) thereof) may accept Amyris's offer as to the full number of New Securities offered to it or any lesser number by written notice thereof delivered by Total to Amyris prior to the expiration of the Participation Exercise Period (an “ Acceptance Notice ”), in which event Amyris shall sell, and Total (or such Permitted Transferee thereof) shall buy, upon the terms specified in the Issuance Notice, the number of New Securities agreed to be purchased by Total (or such Permitted Transferee

14



thereof) on a date not later than 5 days (or such longer period as may be provided to any other investor with similar rights to purchase new securities or is required by law) after the expiration of the Participation Exercise Period. The purchase price of the first $30,000,000 of New Securities purchased by Total (or such Permitted Transferee thereof) pursuant to this Section 4.1 on or prior to December 31, 2013 shall be payable by delivering Securities in an aggregate principal amount equal (including any accrued and unpaid interest thereon) to such purchase price to Amyris, which Securities shall thereupon be cancelled and extinguished by Amyris. The purchase price of any New Securities purchased by Total (or such Permitted Transferee thereof) pursuant to this Section 4.1 on or prior to December 31, 2013 above $30,000,000, and the Purchase Price of any New Securities purchased by Total (or such Permitted thereof) pursuant to this Section 4.1 on or after January 1, 2014, shall be payable in cash. In the event any purchase by Total (or such Permitted Transferee thereof) is not consummated, other than as a result of the fault of Amyris, within the time period specified above, and Amyris had elected that the New Securities to be offered to Total pursuant to the Issuance Notice be in lieu of the New Securities proposed to be issued to such third party, Amyris may issue the New Securities subject to purchase by Total (or such Permitted Transferee thereof) to the third party to which Amyris intended to sell such New Securities on terms and conditions no less favorable to Amyris than the terms specified in the Issuance Notice.

ARTICLE 6
OTHER PRODUCTS

SECTION 6.1.     Other Products . The parties are to comply with the other product principles previously agreed.

ARTICLE 7
REPRESENTATIONS AND WARRANTIES OF AMYRIS

As an inducement to Total to enter into this Master Agreement and the other Transaction Documents, Amyris hereby represents, warrants and covenants to Total as follows:
SECTION 7.1.     Organization . Amyris is duly organized, validly existing, and in good standing under the laws of the jurisdiction of its organization.

SECTION 7.2.     Power . Amyris has all requisite power to execute and deliver this Master Agreement and the other Transaction Documents and to carry out and perform its obligations hereunder and thereunder.

SECTION 7.3.     Authorization . The execution, delivery, and performance of this Master Agreement and the other Transaction Documents by Amyris has been duly authorized by all requisite action, and this Master Agreement constitutes, and the other Transaction Documents when executed will constitute, the legal, valid, and binding obligation of Amyris enforceable in accordance with their terms, except (a) as limited by applicable bankruptcy, insolvency, reorganization, moratorium, and other laws of general application affecting enforcement of creditors' rights generally, and (b) as limited by laws relating to the availability of specific performance, injunctive relief or other equitable remedies.


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SECTION 7.4.     Consents and Approvals . Amyris need not give any notice to, make any filing with, or obtain any authorization, consent, or approval of any government or governmental agency in order to consummate the transactions contemplated by this Master Agreement or the other Transaction Documents.

SECTION 7.5.     Non-Contravention . The execution and delivery of the this Master Agreement, and the performance by Amyris of its obligations under this Master Agreement and/or the consummation of the transactions contemplated hereby, will not (a) conflict with, result in the breach or violation of, or constitute (with or without the giving of notice or the passage of time or both) a violation of, or default under, (i) any bond, debenture, note or other evidence of indebtedness, or under any lease, license, franchise, permit, indenture, mortgage, deed of trust, loan agreement, joint venture or other agreement or instrument to which Amyris or any subsidiary is a party or by which it or its properties may be bound or affected, (ii) Amyris's Restated Certificate of Incorporation, as amended and as in effect on the date hereof (the “Certificate of Incorporation”), Amyris's Bylaws, as amended and as in effect on the date hereof (the “Bylaws”), or the equivalent document with respect to any subsidiary, as amended and as in effect on the date hereof, or (iii) any statute or law, judgment, decree, rule, regulation, ordinance or order of any court or governmental or regulatory body (including The NASDAQ Stock Market), governmental agency, arbitration panel or authority applicable to Amyris, any of its subsidiaries or their respective properties, except for the Amyris Stockholder Approval, if required pursuant to Section 271 of the Delaware General Corporation Law, and any notice or approval required under any Competition Laws, and except in the case of clauses (i) and (iii) for such conflicts, breaches, violations or defaults (A) under any assignment provisions in any contract to be assigned to JVCO, or (B) that would not be likely to have, individually or in the aggregate, a material adverse effect, individually or in the aggregate, upon the business, properties, tangible and intangible assets, liabilities, operations, prospects, financial condition or results of operation of Amyris and its subsidiaries or the ability of Amyris or any of its subsidiaries to perform their respective obligations under the Transaction Documents, or (b) result in the creation or imposition of any lien, encumbrance, claim, security interest or restriction whatsoever upon any of the material properties or assets of Amyris or any of its subsidiaries or an acceleration of indebtedness pursuant to any obligation, agreement or condition contained in any material bond, debenture, note or any other evidence of indebtedness or any material indenture, mortgage, deed of trust or any other agreement or instrument to which Amyris or any if its subsidiaries is a party or by which Amyris or any of its subsidiaries is bound or to which any of the property or assets of Amyris is subject.

ARTICLE 8
REPRESENTATIONS AND WARRANTIES OF TOTAL

As an inducement to Amyris to enter into this Master Agreement and the other Transaction Documents, Total hereby represents, warrants and covenants to Amyris as follows:
SECTION 8.1.     Organization . Total is duly organized, validly existing, and in good standing under the laws of the jurisdiction of its organization.


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SECTION 8.2.     Power . Total has all requisite power to execute and deliver this Master Agreement and the other Transaction Documents and to carry out and perform its obligations hereunder and thereunder.

SECTION 8.3.     Authorization . The execution, delivery, and performance of this Master Agreement and the other Transaction Documents by Total has been duly authorized by all requisite action, and this Master Agreement constitutes, and the other Transaction Documents when executed will constitute, the legal, valid, and binding obligation of Total enforceable in accordance with their terms, except (a) as limited by applicable bankruptcy, insolvency, reorganization, moratorium, and other laws of general application affecting enforcement of creditors' rights generally, and (b) as limited by laws relating to the availability of specific performance, injunctive relief or other equitable remedies.

SECTION 8.4.     Consents and Approvals . Total need not give any notice to, make any filing with, or obtain any authorization, consent, or approval of any government or governmental agency in order to consummate the transactions contemplated by this Master Agreement or the other Transaction Documents.

SECTION 8.5.     Non-Contravention . Neither the execution and the delivery of this Master Agreement and the other Transaction Documents, nor the consummation of the transactions contemplated hereby and thereby, will violate in any material respect any constitution, statute, regulation, rule, injunction, judgment, order, decree, ruling, charge, or other restriction of any government, governmental agency, or court to which Total is subject. No approval, waiver, or consent by Total under any instrument, contract, or agreement to which Total or any of its Affiliates is a party is necessary to consummate the transactions contemplated hereby or by the other Transaction Documents.

ARTICLE 9
MISCELLANEOUS

SECTION 9.1.     Amendments . This Master Agreement may only be amended, modified, or waived in writing with the prior written consent of the parties hereto.

SECTION 9.2.     Assignment; Successors and Assigns . This Master Agreement may not be assigned by either party without the prior written consent of the other party. This Master Agreement and all provisions thereof shall be binding upon, inure to the benefit of, and are enforceable by the parties hereto and their respective successors and permitted assigns. Notwithstanding the foregoing, neither this Master Agreement or any right, remedy, obligation or liability arising hereunder or by reason hereof shall be assignable other than in connection with an assignment permitted pursuant to and in accordance with this Master Agreement, except that if any party hereto is entitled to assign its rights or obligations under any other Transaction Document, the rights and obligations of such party under this Master Agreement relating to the rights and obligations assigned under the Transaction Document in question may be assigned by such party, except such party shall remain liable for such related obligations hereunder.


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SECTION 9.3.     Notices . All notices, requests, and other communications hereunder shall be in writing and will be deemed to have been duly given and received (a) when personally delivered, (b) when sent by facsimile upon confirmation of receipt, (c) one business day after the day on which the same has been delivered prepaid to a nationally recognized courier service, or (d) five business days after the deposit in the United States mail, registered or certified, return receipt requested, postage prepaid, in each case to the applicable address set forth below:

If to Amyris, to:

Amyris, Inc.
5885 Hollis Street, Suite 100
Emeryville, CA 94608
United States of America
Attn:     General Counsel
Fax No.: +1 (510) 842-1460

with a copy (which shall not constitute notice) to:

Shearman & Sterling LLP
Four Embarcadero Center, Suite 3800
San Francisco, CA  94111-5994
United States of America
Attn:    Michael S. Dorf
Fax No.: +1 (415) 616-1446

and

Covington & Burling LLP
One Front Street
San Francisco, CA 94111
United States of America
Attn: Amy Toro
Fax No.: +1 (415)955-6586

If to Total, to:

Total Gas & Power USA, SAS
2, place Jean Millier
La Défense 6
92400 Courbevoie
France
Attn:     Bernard Clément
Fax. No.: +331 4744 8178

with a copy (which shall not constitute notice) to:


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Wilson Sonsini Goodrich & Rosati
Professional Corporation
650 Page Mill Road
Palo Alto, CA 94304
United States of America
Attn:     David J. Segre
Michael Occhiolini
Richard Cameron Blake
    
Fax No.: +1 (650) 493-6811

Any party hereto from time to time may change its address, facsimile number, or other information for the purpose of notices to that party by giving notice specifying such change to the other parties hereto. Total and Amyris may each agree in writing to accept notices and other communications to it hereunder by electronic communications pursuant to procedures reasonably approved by it; provided that approval of such procedures may be limited to particular notices or communications.
SECTION 9.4.     Governing Law; Jurisdiction .

(a) Governing Law . This Master Agreement, and the provisions, rights, obligations, and conditions set forth herein, and the legal relations between the parties hereto, including all disputes and claims, whether arising in contract, tort, or under statute, shall be governed by and construed in accordance with the laws of the State of New York without giving effect to its conflict of law provisions.

(b) Jurisdiction . Any and all disputes arising out of, or in connection with, the interpretation, performance, or nonperformance of this Master Agreement or any and all disputes arising out of, or in connection with, transactions in any way related to this Master Agreement and/or the relationship between the parties shall be litigated solely and exclusively before the United States District Court for the Southern District of New York. The parties consent to the in personam jurisdiction of said court for the purposes of any such litigation, and waive, fully and completely, any right to dismiss and/or transfer any action pursuant to 28 U.S.C. § 1404 or 1406 (or any successor statute). In the event the United States District Court for the Southern District of New York does not have subject matter jurisdiction of said matter, then such matter shall be litigated solely and exclusively before the appropriate state court of competent jurisdiction located in the state of New York.

SECTION 9.5.     Severability . In the event that any provision of this Master Agreement or the application of any provision hereof is declared to be illegal, invalid, or otherwise unenforceable by a court of competent jurisdiction, the remainder of this Master Agreement shall not be affected except to the extent necessary to delete such illegal, invalid, or unenforceable provision unless that provision held invalid shall substantially impair the benefits of the remaining portions of this Master Agreement.


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SECTION 9.6.     Headings . The headings in this Master Agreement are for convenience of reference only and shall not constitute a part of this Master Agreement, nor shall they affect its meaning, construction, or effect.

SECTION 9.7.     Entire Agreement . This Master Agreement, along with the Transaction Documents and the Schedules, Exhibits and Appendices thereto, set forth the entire, complete and final agreement of the parties with respect to the subject matter hereof and supersede all prior agreements and understandings, inducements or conditions, express or implied, oral or written. The parties acknowledge and agree that this Master Agreement is the result of negotiations between the parties, each with the benefit of counsel, and therefore this Master Agreement shall not be construed against the drafter hereof.

SECTION 9.8.     Counterparts . This Master Agreement may be executed in one or more counterparts, each of which shall constitute an original, but all of which, when taken together, shall constitute but one instrument, and shall become effective when one or more counterparts have been signed by each party hereto and delivered to the other party. Facsimile signatures shall be deemed originals for all purposes hereunder.

[ Signature page follows ]



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IN WITNESS WHEREOF, the parties hereto have caused this Master Agreement to be executed as of the date first written above by their respective officers thereunto duly authorized.
AMYRIS, INC.
By: /s/ John Melo    
Name: John Melo
Title: President and Chief Executive Officer


TOTAL GAS & POWER USA, SAS
By: /s/ Bernard Clément    
Name: Bernard Clément
Title: Authorized Signatory




[Signature Page to Master Framework Agreement]


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CONFIDENTIAL TREATMENT REQUESTED. CERTAIN PORTIONS OF THIS DOCUMENT HAVE BEEN OMITTED PURSUANT TO A REQUEST FOR CONFIDENTIAL TREATMENT AND, WHERE APPLICABLE, HAVE BEEN MARKED WITH AN ASTERISK TO DENOTE WHERE OMISSIONS HAVE BEEN MADE. THE CONFIDENTIAL MATERIAL HAS BEEN FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION.


SECOND AMENDMENT TO THE TECHNOLOGY
LICENSE, DEVELOPMENT, RESEARCH AND COLLABORATION AGREEMENT


This Second Amendment (the “ Second Amendment ”) to the Technology License, Development, Research and Collaboration Agreement entered into as of June 21, 2010 (as amended by that certain First Amendment dated as of November 23, 2011 (the “ First Amendment ”), the “ Agreement ”) is entered into as of July 30, 2012 (the “ Second Amendment Date ”) by and between:

AMYRIS, Inc., a Delaware corporation, having its place of business at 5885 Hollis Street, Suite 100, Emeryville, California 94608 (“ AMYRIS ”),

and

TOTAL Gas & Power USA SAS, a company existing and organized under the French laws having its head office located at Tour Coupole, 2 place Jean Millier, 92810 Courbevoie, France (“ TOTAL ”).

AMYRIS and TOTAL are sometimes referred to herein individually as a “ Party ” and collectively as the “ Parties .”

RECITALS

WHEREAS, on June 21, 2010, AMYRIS and TOTAL Gas & Power USA Biotech, Inc. entered into the Agreement to define the general terms and conditions under which the Parties can establish development projects related to the research, development, production and commercialization of certain products;

WHEREAS, TOTAL Gas & Power USA Biotech, Inc., assigned the Agreement to TOTAL as set forth in that certain letter dated January 11, 2011;

WHEREAS, AMYRIS and TOTAL entered into the First Amendment, certain JV Principles and the Cover Letter as of November 23, 2011;

WHEREAS, the Parties have entered into that certain Master Agreement dated of even date herewith (the “ Master Agreement ”) (along with that certain Stock Purchase Agreement and Notes (each as defined in the Master Agreement)), pursuant to which the Parties have agreed upon certain terms in order to conduct an exclusive strategic partnership (as described therein) for the research, development, production and commercialization of JV Products (as defined below), including possibly through the formation of a joint venture (such joint venture as is established pursuant to the Master Agreement, the “ JV Company ”);

WHEREAS, the Parties desire to conduct the above mentioned research and development activities under the terms of the Agreement (as amended by this Second Amendment), and they desire to amend the Agreement to describe and address specific provisions pertaining to such activities;

WHEREAS, this Second Amendment supersedes the First Amendment with respect to the matters set forth herein, and sets forth the terms on which the Parties will, as contemplated by the

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Agreement, cooperate in the development, production and commercialization of the JV Products; and
 
NOW THEREFORE, for good and valuable consideration the receipt of which is hereby acknowledged, the Parties, intending to be legally bound, agree to the following provisions and to amend the Agreement, as follows:

1.
New Definitions . The Parties hereby agree to add the following defined terms to Section 1:

AMYRIS Farnesene IP ” means all Inventions owned or Controlled by AMYRIS or its Affiliates (other than a Third Party acquirer of AMYRIS) necessary or, solely in the case of Farnesene Production IP included therein, useful (x) to develop and/or optimize the processes of making farnesene from the Commercial Farnesene Strain, purifying it from the fermentation broth and converting farnesene into farnesane and/or (y) to Make and Sell JV Products; provided that if there is a Jet Go Decision, then AMYRIS Farnesene IP shall thereafter be limited to (a) those Inventions that are necessary or, solely in the case of Farnesene Production IP included therein, useful (i) to develop and/or optimize the processes of making farnesene from the Commercial Farnesene Strain and purifying it from the fermentation broth and converting farnesene into farnesane and/or (ii) to Make and Sell JV Products, and (b) any such Inventions first developed or Controlled by AMYRIS or its Affiliates after the date of the Jet Go Decision shall be included in the AMYRIS Farnesene IP only if the JV Company (or TOTAL in the case of a TOTAL Buy-Out) agrees to pay a commercially reasonable royalty (to be determined with regard to such Inventions following its development with regard thereto ) . For clarity, AMYRIS Farnesene IP includes without limitation, AMYRIS Technology, AMYRIS Collaboration IP, AMYRIS Hydrogenation IP, AMYRIS-Owned Improvement Scope IP and AMYRIS' interest in Jointly-Owned Improvement Scope IP and Jointly Owned Collaboration IP. The Parties have agreed in writing on a list of the patents and patent applications Controlled by AMYRIS as of the Second Amendment Date that are included within AMYRIS Farnesene IP (the “ Patent List ”).

“AMYRIS Hydrogenation IP” means any AMYRIS Background IP and AMYRIS Non-Collaboration IP in each case that is Controlled by AMYRIS or its Affiliates (other than a Third Party acquirer of AMYRIS, Inc.) and is necessary in order to hydrogenate farnesene into farnesane.

AMYRIS Farnesene Included IP ” means any (i) AMYRIS Background IP and any AMYRIS Non-Collaboration IP, in each case that is Controlled by AMYRIS or its Affiliates as of the Second Amendment Date, and (ii) AMYRIS Non-Collaboration IP developed after the Second Amendment Date (other than by a Third Party acquirer of AMYRIS, Inc.), in each case that (x) encompass general means of practicing synthetic biology or (y) are necessary or useful for the R&D Activities contemplated in connection with the Biofene Development Project.

Biofene Development Project means the project and activities described in the Biofene Development Project Plan.


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Biofene Development Project Plan ” means the written Development Project Plan agreed by the Parties for the research, development, and scale-up production activities to be conducted pursuant to this Second Amendment.

Biofene Development Project Scope ” means the following collective feedstock, host cell, metabolic pathway, Compound and Product:
(a)    feedstock consisting of one or both: (i) simple sugars ( e.g. , monosaccharides and disaccharides such as glucose, sucrose) or glycerol; or (ii) simple sugars or oligosaccharides or any of their derivatives obtained by transformation of any of the following biomasses: (A) amylase and amylopectin; (B) cellulose; (C) inuline; (D) lignocellulose; and (E) hemicellulose;
(b)    a Strain as the host cell;
(c)    Mevalonate Pathway or DXP Pathway as the pathway;
(d)    an isoprenoid compound as the Compound; and
(e)    Diesel Product or Jet Product, as the case may be, as the Product; provided, however, that Diesel Products and Jet Products other than Farnesane Diesel Products and Farnesane Jet Products are included in the Biofene Development Project Scope solely for the purpose of the exclusivity afforded under the Agreement with respect to the Biofene Development Project Scope and, if there is an Improvement Scope for the Biofene Development Project, the Improvement Scope, and do not constitute Products for any other purposes unless and until the Parties agree in writing.

For clarity, in order for activities to be within the Biofene Development Project Scope, all of the elements described therein (feedstock, host cell, pathway, Compound, and Product) must be as described above. If any of such elements differs, then the activities are considered outside of the Biofene Development Project Scope.

Commercial Farnesene Strain ” means a Commercial Strain designed for the production of farnesene.

Diesel Product ” shall mean one or more fermentation produced isoprenoid(s) that may or may not be hydrogenated or hydroprocessed, which when blended with petroleum diesel, meet the ASTM D975 specification, the EN590 European standard or the equivalent of either such standard, in each case, for use as a diesel fuel.

Farnesane Diesel Product ” means a Diesel Product that is farnesane, wherein the isoprenoid is farnesene.

Farnesane Jet Product ” means a Jet Product that is farnesane, wherein the isoprenoid is farnesene.

Farnesene Production IP means any and all (a) AMYRIS Farnesene Included IP and (b) Collaboration IP and (c) Improvement Scope IP, in each case that is necessary or useful to (i) produce farnesene from fermentation of a Farnesene Strain or (ii) purify such farnesene from the fermentation medium to hydrogenation grade.

Farnesene Strain ” means any Strain that produces farnesene.

Field means diesel fuel and/or jet fuel applications; provided in the case of a Jet Go Decision, the Field shall thereafter not include diesel fuel applications.


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Go Decision ” shall have the meaning set forth in Section 2.2(b) of the Master Agreement.

Jet Go Decision ” shall have the meaning set forth in Section 2.2(b) of the Master Agreement.

Jet Product shall mean one or more fermentation produced isoprenoid(s) that may or may not be hydrogenated or hydroprocessed, which when blended with petroleum-derived jet fuel, meet the ASTM D 1655 specification or the equivalent of such standard for use as a jet fuel.

JV Product ” means (i) farnesene for use in Diesel Product or Jet Product, (ii) Farnesane Diesel Product, or (iii) Farnesane Jet Product.

Manufacture ” means make and have made (including practicing and using for the foregoing purposes).

Master Agreement has the meaning defined in the recitals of this Second Amendment.

No-Go Decision ” shall have the meaning set forth in Section 2.2(a) of the Master Agreement.

TOTAL Buy-Out ” shall mean TOTAL's purchase of AMYRIS' interest in the potential JV Company (prior to its formation) pursuant to Section 3.3 of the Master Agreement.

Capitalized terms used in this Agreement that are not defined in this Second Amendment shall have the meaning set forth in the Agreement or the Master Agreement, as applicable.

2.
Designation of JV Products as Products and Large Market Products. The Parties hereby agree that (a) pursuant to Section 2.1 of the Agreement, on and after the Second Amendment Date, each Farnesane Diesel Product and Farnesane Jet Product shall be considered a Product, notwithstanding the exclusion of farnesene-derived diesel as a Specific Product from the definition of Products, and (b) each Farnesane Diesel Product and Farnesane Jet Product is deemed a Large Market Product and the procedures set forth in Section 2.2(d) of the Agreement with regard to designating Products as Large Market Products are deemed satisfied with regard to the JV Products. For clarity, notwithstanding that farnesene is a JV Product, it is not a Product for the purposes of the Agreement. However, farnesene is a Lead Compound for the Biofene Development Project and may become a Product for the purposes of the Agreement if and when the Parties agree in writing.

3.
Biofene Development Project

A.
Scope . The Parties hereby agree that (a) pursuant to Section 2.2 of the Agreement, as of the Second Amendment Date, the Biofene Development Project is deemed to be approved by the Management Committee in accordance with the terms of the Agreement, (b) the Improvement Scope for the Biofene Development Project shall not be any broader than the Biofene Development Project Scope, (c) any and all Inventions developed by or on behalf of either Party that constitute Improvement Scope IP for the Biofene Development Project, which Inventions relate to the production of farnesene from fermentation of a Farnesene Strain and purification of such farnesene from

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fermentation medium, shall be deemed to be Main IP (and not Improvement Scope IP and accordingly the last sentence of Section 2.3 shall not apply), and (d) TOTAL may not exercise the TOTAL R&D Option with respect to Farnesane Diesel Product or the Farnesane Jet Product.

B.
Term . The Biofene Development Project shall continue unless and until the earliest to occur of (i) the Parties agree to terminate the Biofene Development Project by mutual written agreement, (ii) the achievement of the final milestone for the Biofene Development Project, as determined by the Management Committee, or (iii) July 31, 2016 unless otherwise determined by the Management Committee and in no event later than March 1, 2017 (the earlier of clause (ii) or (iii), “ Project Completion Date ”) or (iv) TOTAL's exercise of a No-Go Decision under the Master Agreement as to both JV Products.

4.
Governance . The governance of the Biofene Development Project shall be as follows and in the event of any inconsistency with the terms of Section 2.5 of the Agreement, the following terms shall govern the Biofene Development Project:

A.
Decision Making . Decision-making with regard to the Biofene Development Project shall be made by the Management Committee, subject to the terms of this Second Amendment. The Joint Steering Committee shall have no role or responsibilities in the Biofene Development Project and any responsibilities assigned to the Joint Steering Committee shall be reassigned to the Management Committee for such project. All decisions of the Management Committee shall be by majority vote. In the event of a disagreement at the Management Committee, such dispute shall be referred to the CEO of AMYRIS and the Senior Vice President, Business and Operations, of TOTAL or his/her designee for resolution within ten Business Days and they shall resolve such dispute.

B.
Management Committee Responsibilities . With regard to the Biofene Development Project, the general role of the Management Committee with respect to the Biofene Development Project shall be to oversee progress of and manage, as described in Exhibit A , the Biofene Development Project with disputes resolved as described in Section A. The Management Committee shall have authority over Biofene Development Project objectives, content and activities as described on Exhibit A hereto.

C.
Access to Information AMYRIS shall provide TOTAL with information relating to Biofene Development Project as specified on Exhibit D hereto.

D.
AMYRIS Responsibilities . AMYRIS shall have, on a daily basis, operational responsibility for the execution of the specific activities undertaken within the Biofene Development Project, consistent with the Biofene Development Project Plan, subject to the oversight and direction of the Management Committee as specified in Section 4.B above.

5.
Use of Collaboration IP . If there is a No-Go Decision or if the Biofene Development Project otherwise terminates by mutual agreement of the Parties, the restrictions set forth in Section 2.2(d) of the Agreement regarding use of Collaboration IP in a project competing with the Biofene Development Project having farnesene as the Lead Compound and Farnesane Diesel Product or Farnesane Jet Product as the Product shall not apply to AMYRIS with

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respect to any Collaboration IP developed under the Biofene Development Project. If there is a Jet-Go Decision, then the restrictions in Section 2.2(d) regarding use of Collaboration IP in a project competing with the Biofene Development Project shall continue to apply to AMYRIS with respect to farnesene as the Lead Compound and Farnesane Jet Product as the Product.

6.
Funding .

A.
Funding of the Biofene Development Project . In lieu of the application of Sections 2.7(a), (b), (c), (e) and (f) of the Agreement, the Parties hereby agree that the Biofene Development Project shall be funded solely under the Master Agreement, except as provided in Section 17 below. The Parties agree that as of the Second Amendment Date, except as otherwise expressly provided in this Second Amendment, the Master Agreement, Stock Purchase Agreement (as defined in the Master Agreement) and Notes (as defined in the Master Agreement), neither Party shall have any obligation to pay for or reimburse the other Party for any R&D Costs incurred with respect to the Biofene Development Project.

B.
Prior R&D Costs related to the Renewable Diesel Program and the Biojet Development Program; Collaboration IP . The aggregate amount of US$63.3 million paid by TOTAL for R&D Costs for the Biojet Development Program and the Renewable Diesel Program (as defined in the First Amendment) were paid for R&D Activities. Such prior payments are not refundable to TOTAL, except in the case of the payments under the Renewable Diesel Program as expressly provided in the Notes. Certain Inventions and related intellectual property were developed in connection with such R&D Activities prior to the date of this Second Amendment, and for clarity all such Inventions and related intellectual property shall be treated as Collaboration IP under the Agreement.

C.
Section 2.7 of Agreement . The Parties understand and agree that the funding described in Section 6.A above is in lieu of any other payments for the future conduct of any R&D Activities under the Agreement under the Biofene Development Project (unless otherwise agreed by the Parties in the future), and as of the Second Amendment Date no further amounts are due or shall be due from TOTAL under Section 2.7(c) of the Agreement for any R&D Activities or R&D Costs for the Biofene Development Project or any other project (but for clarity Section 2.7(a) would govern any future projects under the Agreement other than the Biofene Development Project).

7.
Exclusivity .

A.
Notwithstanding the provisions of Section 2.8(a) of the Agreement, the one-year period described in the first sentence of Section 2.8(a) shall not apply where farnesene is the Lead Compound and Farnesane Diesel Product or Farnesane Jet Product is the Product within the Biofene Development Project Scope.

B.
The Parties agree that the following activities may be conducted during the term of the Biofene Development Project as described below, and for clarity agree that the limitations of Section 2.3 of the Agreement shall not apply to such activities:

1.
Permitted Activities . AMYRIS or TOTAL, as the case may be, may, itself or with Third Parties, conduct the activities listed below, and such activities shall not be

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treated as part of the Biofene Development Project: (i) hydrogenation of farnesene into farnesane for use in diesel fuels or jet fuels; (ii) certification of farnesane for use in diesel fuels, and (iii) certification of farnesane for use in jet fuels.

2.
Non-Collaboration IP . With respect to activities conducted independently by one or both Parties under Section 7.B.1 above, any Invention(s) made or otherwise developed by a Party(ies) in connection with such activities shall solely owned by such Party (or in the case of joint Inventions, jointly), and all such Invention(s) shall be Non-Collaboration IP.

3.
Diesel Certification Activities . To avoid unnecessary duplication of any activities conducted independently by the Parties with respect to Section 7.B.1(ii) above, the Parties agree to coordinate their activities relating to certification (per ASTM or EN or other applicable standards) of Farnesane Diesel Product. Each Party shall be responsible for its own costs incurred in connection with such activities. Any documentation and intellectual property made or otherwise generated in connection with activities conducted in order to certify the Farnesane Diesel Product (“ Diesel Certification Materials ”) shall be solely owned by the Party developing such documentation and intellectual property. If the JV Company (or any of its Affiliates or sublicensees) uses the Diesel Certification Materials to sell the Farnesane Diesel Product as certified, then the JV Company shall be obligated to repay to TOTAL and/or AMYRIS all documented amounts expended by such Parties in the creation of the applicable Diesel Certification Materials generated after the Second Amendment Date; provided however, for activities conducted by AMYRIS Brazil in furtherance of its business in Brazil, no reimbursement shall apply if the Brazil Business has been purchased by the JV Company.

4.
Jet Certification Activities. The Parties intend to jointly conduct the activities relating to certification (per ASTM or DefSTAN) of Farnesane Jet Product. TOTAL shall be responsible for leading such activities and shall coordinate with AMYRIS to ensure that work being conducted by AMYRIS in Brazil is not duplicated. Each Party shall bear the costs of the participation of its own personnel and consultants in such activities. Any documentation and intellectual property generated by either Party in connection with activities conducted in order to certify the Farnesane Jet Product (the “ Jet Certification Materials ”) may be used, without charge (a) by AMYRIS to support its business development initiatives in Brazil, (b) by TOTAL. If the JV Company uses the Jet Certification Materials to sell Farnesane Jet Product as certified, then the JV Company shall be obligated to repay to TOTAL and/or AMYRIS all documented amounts expended by such Party in generating the applicable Jet Certification Materials generated after the Second Amendment Date; provided however, for activities conducted by AMYRIS Brazil in furtherance of its business in Brazil, no reimbursement shall apply if the Brazil Business has been purchased by the JV Company.

5.
Recovery and Purification Activities . With regard to process development to recover and purify farnesene from fermentation broth for jet fuel applications, if the Management Committee approves independent development of such process development by TOTAL, TOTAL may conduct these activities at its expense, but such activities shall be considered conducted within the Biofene Development Project and the Agreement. If the JV Company uses any Collaboration IP

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generated in connection with such activities by TOTAL to Manufacture the JV Products on a commercial basis, then the JV Company shall be obligated to repay to TOTAL all documented amounts expended by TOTAL or its Affiliates in generating the applicable Collaboration IP. To the extent that AMYRIS resource constraints may prevent timely development of such recovery and purification processes, which would delay of the joint jet certification activities, then the Management Committee will endeavor to approve affirmatively the pursuit of this activity by TOTAL or an appropriate Third Party.

C.
Additional Licenses . AMYRIS hereby grants to TOTAL a non-exclusive, royalty-free license under the AMYRIS Farnesene IP (1) to conduct the activities permitted under Section 7.B.1(i) of this Second Amendment; and (2) to conduct the activities permitted under Section 7.B.1(ii) and (iii) of this Second Amendment, in each case (1) and (2) in accordance with the Agreement. For clarity, such license does not cover activities conducted after termination of the Biofene Development Project unless otherwise agreed by the Parties in writing.

8.
Material Transfer . To facilitate the conduct of the permitted activities set forth in Section 7 of this Second Amendment, AMYRIS shall sell to TOTAL, at AMYRIS' actual manufacturing cost, such quantities of farnesene, farnesane and other farnesene derivatives as TOTAL may reasonably request during the term of the Biofene Development Project under an MTA that is substantially similar to the MTA template agreed by the Parties.

9.
Additional Licenses to AMYRIS and JV .

A.
Hydrogenation Patent Rights . With respect to any patent rights filed on results generated in the development activities conducted by TOTAL pursuant to Section 7.B.1(i) of this Second Amendment, if requested by AMYRIS, TOTAL will grant to AMYRIS a non-exclusive, sublicenseable, royalty-bearing license, under patents resulting from TOTAL hydrogenation activities with farnesene and/or farnesene derivatives provided by AMYRIS, to the extent such patents  would enable AMYRIS to practice AMYRIS Farnesene IP that AMYRIS otherwise could not practice due to the claims of the TOTAL patents to Make and Sell (i) in the Excluded Markets, products derived from farnesene, or (ii) products other than those that compete with products commercialized by TOTAL or its Affiliates, on a country by country basis. In the event that AMYRIS wishes to obtain a license for any such products, it may notify TOTAL of the proposed products and jurisdictions for which it wishes to obtain a license, and in such case, the Parties shall promptly consult regarding TOTAL's plans and activities with respect to such products and jurisdictions. If there is a disagreement regarding whether the products compete with those products commercialized by TOTAL or its Affiliates, as described in clause (ii), the senior executives shall as soon as possible meet and attempt in good faith to resolve the disagreement. If they are unable to reach agreement on the behalf of the Parties such disagreement shall be resolved by arbitration. With respect to any published patent applications or patents filed on results generated in the development activities conducted by TOTAL pursuant to Section 7.B.1(i) of this Second Amendment if requested by the JV Company, TOTAL will grant to the JV Company an exclusive, worldwide, royalty-bearing (at a commercially reasonable rate) license, under published patent applications and patents resulting from TOTAL hydrogenation activities with farnesene and/or farnesene derivatives provided by AMYRIS conducted pursuant to Section 7 above, to develop

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and/or optimize the process of making farnesene from the Commercial Farnesene Strain and purifying and converting farnesene into farnesane, and to Make and Sell JV Products. The foregoing license shall, with TOTAL's further written consent, which shall not be unreasonably withheld, be sublicenseable to Third Party toll manufacturers.

B.
Certification . With respect to any intellectual property rights arising out of the certification activities conducted by TOTAL pursuant to Section 7.B.1(ii) or (iii) of this Second Amendment, if requested by the JV Company, TOTAL will grant to the JV Company an exclusive, worldwide, sublicensable, royalty-free license, subject to reimbursement for the documented amounts described in Section 7.B.4 of this Second Amendment, under such intellectual property rights necessary to use the Jet Certification Materials and Diesel Materials, in each case as certified, as described in Section 7.B.1 of this Second Amendment and to Make and Sell Farnesane Diesel Product or Farnesane Jet Product, in each case as certified. With respect to any intellectual property rights arising out of the certification activities conducted by AMYRIS pursuant to Section 7.B.1(ii) or (iii) of this Second Amendment, if requested by the JV Company or by TOTAL (in the case of a TOTAL Buy-Out), AMYRIS will grant to the JV Company or to TOTAL (in the case of a TOTAL Buy-Out), an exclusive, worldwide, sublicensable, royalty-free license, subject to reimbursement for the documented amounts described in Section 7.B.1 of this Second Amendment under such intellectual property rights to use the Jet Certification Materials and Diesel Materials as described in Section 7.B.1 of this Second Amendment and to Make and Sell Farnesane Diesel Product or Farnesane Jet Product.

C.
Implementation of License Rights . For any license described in this Section 9, if the JV Company, TOTAL (in the case of a TOTAL Buy-Out) or AMYRIS, as applicable, provides notice that it wishes to obtain a license as described therein, the licensor and the licensee shall promptly negotiate in good faith royalty and other terms, which shall reflect market conditions for the licensed intellectual property rights.

10.
TOTAL Go/No-Go Decisions .

A.
No-Go Decisions . In the event that under the Master Agreement, TOTAL exercises No-Go Decision (including a Final No-Go Decision) for both JV Products, then concurrently (i) the Biofene Development Project shall terminate (if not already completed); and (ii) the Farnesane Diesel Product and the Farnesane Jet Product shall cease to be Products (and farnesene shall cease to be a Lead Compound for the Biofene Development Project) for the purposes of the Agreement.

B.
Jet Go Decision . In the case of a Jet Go Decision, the Farnesane Diesel Product shall then cease to be a Product for the purposes of the Agreement and shall cease to be a JV Product, but the Farnesane Jet Product shall continue to be a Product and a JV Product. In such case the Field thereafter shall no longer include diesel fuels.

11.
AMYRIS Included IP; JV Licenses .

A.
AMYRIS Farnesene Included IP and AMYRIS Hydrogenation IP as listed in Exhibit A shall be considered in the AMYRIS Included IP pursuant to Section 6.1(c) of the Agreement (without the need for the procedures set forth therein) solely for the

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Biofene Development Project for all purposes under the Agreement, except as otherwise provided in this Second Amendment. Any other Background IP or Non-Collaboration IP that is Controlled by AMYRIS or its Affiliates may be introduced as AMYRIS Included IP as per the Agreement.

B.
Notwithstanding the scope of the licenses to be granted to the JV Company pursuant to the Agreement, including Section 6.6(a) of the Agreement, if there is a Go Decision with respect to the applicable JV Product by the deadline specified in the Master Agreement or a Jet Go Decision, in lieu of such licenses, each Party shall grant to the JV Company (or in the case of a TOTAL Buy-Out, AMYRIS shall grant TOTAL) for the JV Products the licenses as set forth on Exhibit B (the “ License Terms ”). Unless otherwise agreed in writing, the definitive license agreement entered into by either Party and the JV Company shall not contain any terms inconsistent with the License Terms applicable to such Party or any material obligations in addition to those set forth in the License Terms as applied to such Party on the JV Company.

C.
Except in the case of a No-Go Decision prior to March 31, 2013, to provide certainty that the licenses decribed in Exhibit B above are available to the JV Company, no later than March 31, 2013,  each Party shall grant certain licenses on certain terms agreed by the Parties.  The Parties agree that the grant of such license from AMYRIS is a material factor in TOTAL's determination regarding whether to make a Go Decision.

D.
If there is a TOTAL Buy-Out, the licenses to be granted to the JV Company by AMYRIS shall be granted, pursuant to the License Terms, to any such entity(ies) as may be designated by TOTAL, in lieu of being granted to the anticipated JV Company.

12.
AMYRIS Agreements with Third Parties .

A.
AMYRIS has informed TOTAL that AMYRIS has received the following two grants from the U.S. government: (i) Scale-Up and Mobilization of Renewable Diesel & Chemical Production from Common Intermediate Using US-Based Fermentable Sugar Feedstocks (IBR Cooperative Agreement), Award No. DE-EE0002869 (the “ IBR Grant ”) and (ii) Biocatalyst Development for the National Advanced Biofuels Consortium (NABC) Subcontract ZFT-0-40623-01 (the “ NABC Grant ”). AMYRIS has further informed TOTAL that none of the subject matter disclosed by the patents and patent applications listed on the Patent List was funded by either the IBR Grant or the NABC Grant, and TOTAL is relying on such representation in entering into this Second Amendment.

B.
TOTAL acknowledges that it is possible that after the Second Amendment, AMYRIS may file one or more patent applications comprising Farnesene Production IP, which patent applications disclose inventions generated under either the IBR Grant or the NABC Grant, thereby subjecting such patent applications and any resulting patents and their use to certain restrictions and obligations to the United States government. TOTAL acknowledges that the rights of AMYRIS, TOTAL and their respective Affiliates', and the rights of the JV Company with regard to the applicable patent applications and patents will be subject to any rights of the U.S. government or any other relevant government entity arising as a result of such grants (including march-in rights) and will be subject to any restrictions on such exploitation. In such case, the

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Management Committee shall agree on how to mitigate or eliminate any adverse impact on the Parties and/or the JV Company.

C. Before entering into any grant or contract that may provide any government or non-for profit entity any rights (e.g., rights provided to the U.S. Government under 35 U.S. 200 et seq. or any similar provisions of foreign law) to any patent application or patents resulting from work done in connection with such grant or contract that might be useful in connection with the conduct of the Biofene Development Project or to Manufacture farnesene to make JV Products or to Make and Sell JV Products, AMYRIS shall notify the Management Committee, which shall agree on how to mitigate or eliminate any adverse impact on the Parties and/or the JV Company.

13.
Limitation of Rights to Use Farnesene Production IP from Licenses . The Parties hereby agree that, notwithstanding the terms of the Agreement, (a) the licenses granted or to be granted to TOTAL in Section 6.3(b) of the Agreement will exclude the right for TOTAL to use Farnesene Production IP for further optimization of a Commercial Farnesene Strain other than by means of random mutagenesis, (b) the licenses in Section 6.2(c) and 6.3(a) of Agreement shall not apply to any JV Product, and (c) the licenses in Sections 6.3(d) and (e) of the Agreement will not include the right of TOTAL to use Farnesene Production IP for the production of farnesene from fermentation of a Farnesene Strain and subsequent purification of farnesene to hydrogenation grade (but for clarity, this clause (c) is not intended to limit the licenses granted to TOTAL in Section 7.C of this Second Amendment or as may arise under the TOTAL Buy-Out or Article 4 of the Master Agreement or are otherwise agreed by the Parties in writing).

The foregoing limitation shall not limit or deprive TOTAL of any rights granted to TOTAL prior to execution of the First Amendment, or that may be granted to TOTAL under the Agreement with respect to (a) any Collaboration IP not made in connection with the Biofene Development Project Plan, or (b) with respect to any Product other than a JV Product.

14.
Terms Relating to JV Activities . In view of the agreement of the Parties to the terms of this Second Amendment and the Master Agreement, Sections 3.1, 3.2 (other than 3.2(a), (c) and (e)) and 3.3 of the Agreement shall not apply to the JV Products.

15.
Representation and Warranty . The following representation and warranty, to be effective as of the Second Amendment Date, is added to Section 8.2 of the Agreement:

AMYRIS represents and warrants as of the Second Amendment Date that to its knowledge there are no pending or issued patent rights of any Third Party that foreclose practice of any AMYRIS Farnesene IP for the following purposes: (i) to Make farnesene using the Mevalonate Pathway, or (ii) to Make and Sell the JV Products. In particular, but without limitation, AMYRIS represents and warrants that Arkion has granted to AMYRIS exclusive worldwide licenses, with the right to grant and authorize sublicenses, to make, have made, use offer for sale and sell any JV Product(s) in the Field, and that the rights retained by Arkion do not permit it or any third party to make, have made, use offer for sale or sell any JV Product(s) for use in the Field.

16.
Exception to AMYRIS Representations, Warranties and Covenants in Section 8.2(q) . The Parties hereby agree that by exception to Section 8.2(q) of the Agreement, Farnesene Strains may be disclosed to any Third Party during the Term by AMYRIS, provided that such

11



disclosure is (a) under conditions of confidentiality and restrictive use to protect their proprietary nature and commercial value and (b) solely in furtherance of AMYRIS' business for products other than JV Products (or the applicable JV Product(s) if rights to such JV Product(s) reverts to AMYRIS (e.g., in the case of a No-Go decision)).

17.
Seconded Employees . Exhibit C shall apply with regard to Seconded Employees for the Biofene Development Project. In particular, but without limitation, the Parties have agreed preliminarily on [*] positions that will be filled by Seconded Employees. The Parties shall negotiate in good faith within ninety (90) days after the Second Amendment Date any amendments to the Secondment Agreement that are required in order to be consistent with the principles in such Exhibit.

18.
Prior R&D Activities Relating to Diesel and Jet .

A.
Existing Biojet Program . The Biojet Development Project approved by the Management Committee on March 4, 2011 shall be suspended as of September 30, 2012 (i.e., no additional work shall be conducted unless and until authorized by the Parties in writing or the Management Committee). During the period from the Second Amendment Date and September 30, 2012, the R&D Activities conducted in the Biojet Development Program shall be focused on preparing a report and a patentability assessment of Inventions generated (as described in Exhibit E ), for the Joint Steering Committee and Management Committee to decide on the additional R&D activities to take prior to suspension of the Biojet Development Project and for clarity, any filing of patent applications with respect to such Inventions shall be governed by Section 6.8 of the Agreement. For clarity, any Inventions made in connection with the Biojet Development Project shall be Collaboration IP.
B.
First Amendment . The First Amendment is superseded by this Second Amendment and as of the Second Amendment Date shall have no force or effect. For clarity, as to those terms defined in both the First Amendment and this Second Amendment, the definition provided in this Second Amendment shall apply. For further clarity, the intent of the Parties is and was that, notwithstanding the terms of Section 8 of the First Amendment, sections (a) and (c) of such Section 8 were not triggered and that the Renewable Diesel Development Project Plan (as defined in the First Amendment) was in effect through the Second Amendment Date (and the intellectual property provisions of the Agreement apply to R&D Activities in connection therewith).

19.
Construction . The principles set forth in Section 13.12 of the Agreement shall apply to this Second Amendment. References to Sections are references to sections of the Agreement except as otherwise expressly provided.

20.
Amendment Effective Date; Incorporation of Terms; Continuing Effect . This Second Amendment shall be deemed effective for all purposes as of the Second Amendment Date. The amendment to the Agreement set forth in this Second Amendment shall be deemed to be incorporated in, and made a part of, the Agreement, and the Agreement and this Second Amendment shall be read, taken and construed as one and the same agreement. Except as otherwise expressly amended by this Second Amendment, the Agreement shall remain in full force and effect in accordance with its terms and conditions, except the First Amendment shall no longer have any force and effect.


[*] Certain portions denoted with an asterisk have been omitted and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested with respect to the omitted portions.


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21.
Entire Agreement . The Master Agreement and the Agreement (including this Second Amendment) contain the entire agreement between TOTAL and AMYRIS with respect to the subject matter hereof and supersedes any and all prior agreements and understandings, oral and written, with respect to such matters. In any conflict between this Second Amendment and the other terms of the Agreement, this Second Amendment shall control.


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THIS SECOND AMENDMENT IS EXECUTED BY THE AUTHORIZED REPRESENTATIVES OF THE PARTIES AS OF THE DATE FIRST WRITTEN ABOVE.



AMYRIS, Inc.    TOTAL Gas & Power USA SAS

By: /s/ John Melo         By: /s/ Bernard Clément    
Name:        Name: Bernard Clément
Title:        Title: Authorized Signatory

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Exhibit A
Management Committee and Technology Committee Responsibilities

Introduction: description of the elements contained in the Biofene Development Project
The Biofene Development Project is composed of Taskforces, and each Taskforce is composed of projects.
AMYRIS and TOTAL initially agree on a Program Description, which includes 1) a coarse description of the Biofene Development Project over [*] and 2) a more detailed description of the Taskforces within the Biofene Development Project within a [*] rolling window:
The Biofene Development Project description for its entire duration includes the following items
[*]
Description of each Taskforce over the coming year includes the following items
Technical performance milestones and KPIs (including specific to Taskforce)

[*] Certain portions denoted with an asterisk have been omitted and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested with respect to the omitted portions.


























1




Roadmap of the projects to achieve such technical performances (objectives, broad base description of the intended activities, end project milestone, overall timing, sequence and dependency of the projects)
Resource distribution between the projects
After the initial agreement on the elements constituting the Biofene Development Project as described above, changes are managed yearly and quarterly by the Management Committee as described in the governance section below.

Management Committee
Role
o    The Management Committee's (MC) main role is to monitor progress of Biofene Development Project and manage the Biofene Development Project down to the Taskforce level.
o    The MC initially agrees on a Program Description (see above), which includes 1) a coarse description of the Biofene Development Project over [*] and 2) a more detailed description of the Taskforces within the Biofene Development Project within a [*] rolling window. After that initial agreement, changes are managed yearly and quarterly as follows:
Yearly basis
o    Review the progress against Biofene Development Project KPIs with particular focus on TaskforcesAssess the achievement of Biofene Development Project milestones
o    Approve any proposed change of Biofene Development Project for the remaining duration of the program
o    Approve Taskforces' content for the next year
Quarterly basis
o    Review the progress against Taskforces KPIs
o    Approve any proposed significant change (including shift of resources across Taskforces higher than [*] or outside of R&D, project creation, termination, change of end project milestone) to Taskforces
o    If exceptionally required in between quarters:
o    Program Directors can request to shift of resources across Taskforces higher than [*], create, terminate projects or change end project milestone within a Taskforce to the Management Committee members who have to respond within [*] (if no response then default is approval)

[*] Certain portions denoted with an asterisk have been omitted and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested with respect to the omitted portions.


2




Decision process
In case of tie vote:
o    AMYRIS and TOTAL write independently the issue and their proposed solutions at the end of the MC meeting and send it to the CEO of AMYRIS and the Senior Vice President, Business and Operations of TOTAL or his/her designee for resolution within one week and they shall resolve such dispute by choosing one of the proposals.
Process
Quarterly review and management process happening in December, March, June, September
Preparation / Pre-reads
o    MC to define an agenda and to request pre-reads two weeks in advance
o    Pre-reads content jointly defined and approved by the MC
-    Quarterly report : progress to plan prepared by each Taskforce
-    Selected in-depth technology topics
-    Specific questions / challenges to be addressed by the SAB
Meeting
o    Technology review - [*] / MC members, Biofene Development Project members as requested
o    MC meeting - [*] / MC members

Technology Committee (TC)
The Technology Committee (TC) is composed of a Collaboration Advisory Board (CAB) and a Scientific Advisory Board (SAB)
Role of the CAB
§    Advisory role
§    to provide general comments on content, progress and direction of the BioFene Development Project
Composition of the CAB
§    Board members of Amyris designated by Amyris from time to time

[*] Certain portions denoted with an asterisk have been omitted and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested with respect to the omitted portions.

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[*]
Role of the SAB
§    to propose solutions to technology challenges identified in the pre-reads
§    to answer questions asked in the pre-reads
Composition of SAB
§    MC members
§    [*] external experts nominated by AMYRIS
§    [*] external experts nominated by TOTAL
Pre-reads (preparation of quarterly review and management meetings)
§    MC to send an agenda to TC two weeks in advance
§    MC to send pre-reads two weeks in advance
§    In-depth pre-reads content jointly defined and approved by the MC
o    Quarterly report : progress to plan prepared by each Taskforce
o    Selected in-depth technology topics
o    Specific questions / challenges to be addressed by the SAB
TC meetings Frequency
§    Quarterly review and management process happens in December, March, June, September
§    Pre-read reports sent to TC every quarter
§    In-person TC meetings every quarter
§    Kick-off meeting TC in Q3 2012
Governance - Quarterly review and management process
1.    Preparation and distribution of pre-reads and meeting agenda to SAB members (two weeks before face-to-face meetings)
2.    [*] - Technology review - [*] / MC members
3.    [*] - Technology review - [*] / TC (external reviewers will have to be present at least every 6 months)

[*] Certain portions denoted with an asterisk have been omitted and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested with respect to the omitted portions.

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4.    [*] - CAB meeting - [*] / CAB members - dedicated to scientific topics of the BioFene program (part of the session can be dedicated to joint R&D/Manufacturing topics that would require to invite the appropriate correspondents)
o    Presentation of progress up-to-date
o    Forum to discuss specific scientific topics (opportunity to invite external reviewers), management topics, budget/resources
o    Plan for next quarters
5.    [*] - MC meeting - [*] / MC members
§    Quarterly review and management process happens in December, March, June, September
Note: the MC will have the option to revise such TC process to optimize its effectiveness.

[*] Certain portions denoted with an asterisk have been omitted and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested with respect to the omitted portions.

































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EXHIBIT B
JV License Terms


License Grants from Amyris

Definitions :
The defined terms used in this key term sheet shall have the meanings set forth in the Agreement (including without limitation the Second Amendment) and the Master Agreement.

License Grant :
Amyris (and/or its applicable Affiliates) shall grant to the JV Company the following perpetual, license, which license shall be irrevocable except as follows: Amyris may terminate the license only [*]. In the case of a dispute as to whether [*] has occurred, termination would be suspended until the resolution of the dispute and the license would terminate only if the arbitrator responsible for resolving such dispute determines that [*] has occurred and [*]. [*] Amyris may seek all remedies, available at law or in equity for any other such breaches, including such damages that it can prove it has suffered or will suffer, but not speculative or punitive damages.

The license would be a non-exclusive, royalty-free license under the Amyris Farnesene IP to develop and/or optimize the process of making farnesene from the Commercial Farnesene Strain and to purify and convert farnesene into farnesane and an exclusive, royalty-free license under the Amyris Farnesene IP to Make and Sell JV Products for use in the Field, in each case within the Territory, but Amyris retains (i) the right to conduct activities within the Improvement Scope as permitted under the Agreement and the conduct of the Biofene Development Project and (ii) the co-exclusive rights to sell JV Products in Brazil, subject to
    

[*] Certain portions denoted with an asterisk have been omitted and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested with respect to the omitted portions.



















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Section 4.1(b) of the Master Agreement, unless and until the Brazil Business is contributed to the JV Company in accordance with the Master Agreement. [*]

For clarity, Amyris retains the right to Make and Sell products for use outside the Field, including the right to Manufacture farnesene for use in such other products.
The licenses granted to the JV Company shall allow it to conduct licensed activities with the JV Products solely for use in the Field.
The JV Company will covenant that it and its Affiliates and, if Total is a sublicensee of the JV Company, Total, shall not exercise the license outside the Field and will not knowingly sell JV Products to customers for use outside the Field and shall bind its other sublicensees to a written provision requiring compliance with the same principle and shall use [*] efforts to enforce such provision. With regard to such provision, the JV Company shall afford third party beneficiary rights to Amyris analogous to the third party beneficiary rights described in the sublicense section below.

For clarity, within the permitted uses under the licenses, there shall be no volume or production limits on the foregoing licenses, and the licenses may be practiced by the JV Company and its sublicensees anywhere in the Territory.

The non-financial terms of License shall be no less favorable to the JV Company than licenses that Amyris and its Affiliates grant to other partners for the Manufacture of farnesene and/or farnesane.

The terms of the license shall include at least the following: [*]


[*] Certain portions denoted with an asterisk have been omitted and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested with respect to the omitted portions.




















2




[*]

All licenses granted to the JV Company shall remain in effect regardless of the equity ownership of the JV Company, and [*].

Sublicense Rights :
The JV Company shall have the right to grant sublicenses, through multiple tiers, of the licenses granted to the JV Company; provided, however, with respect to the Manufacture of farnesene, the JV Company may only grant sublicenses for Manufacture of farnesene solely for sale to the JV Company and its other sublicensees to Make and Sell Products.

Each sublicensee shall be subject to a written sublicense agreement with the JV Company that contains [*].


[*] Certain portions denoted with an asterisk have been omitted and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested with respect to the omitted portions.



































3




Amyris would be a third party beneficiary with a right to enforce a material uncured breach of any of the provisions described in the preceding paragraph of any such sublicense agreement, to the extent that such a sublicensee breach relates to activities conducted with farnesene made by a Commercial Strain and the JV Company fails to act reasonably and as expeditiously as possible under the circumstances to address any such breach (provided that such failure to act expeditiously is not the result of any action or inaction on the part of Amyris). For the avoidance of doubt, the proviso at the end of the previous sentence shall not be deemed to limit any rights of the members of the board of directors of the JV Company to act in the best interests of Amyris in making any determination as a director. Amyris shall have analogous rights in the case of manufacturing subcontractors of the JV Company or its Affiliates or sublicensees if they have access to the Commercial Farnesene Strain.
        
Technology Transfer :
To facilitate the practice of the licenses granted to the JV Company, subject to reasonable confidentiality terms, use restrictions and material transfer provisions consistent with the aforesaid license and sublicense rights, at JV Company's expense, the following shall apply:

Amyris shall deliver to the JV Company Farnesene Strains, agreed specifications therefor and unpatented know-how (in electronic and hard copy format) within the Amyris Farnesene IP, including without limitation, any Amyris Farnesene IP constituting processes and protocols relating to the production of Amyris Farnesene. At least [*] during the term of the license, at the JV Company's expense, Amyris shall deliver to the JV Company any know-how within the Amyris Farnesene IP (in electronic and hard copy format) that was developed by, or otherwise came within the Control of, Amyris since the last disclosure to the JV Company, and provide to the JV Company a written description of any know-how sufficient to allow the JV Company to determine whether it wishes additional information regarding such know-how, and in such case, Amyris shall deliver to the JV Company any such additional requested know-how and other materials or information within the Amyris Farnesene IP.

At the JV Company's request and expense, to facilitate the practice of the licenses granted to the JV Company, Amyris


[*] Certain portions denoted with an asterisk have been omitted and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested with respect to the omitted portions.













4




shall provide to the JV Company (or its designated sublicensee) training and on-site support (by persons directly involved in the development, use, scale-up and/or operation of the Amyris Farnesene IP to implement the practice of the Amyris Farnesene IP and achieve steady state production of farnesene and/or farnesane).

For clarity, the information disclosed in any such information transfer shall only be used pursuant to the license above.

IP Ownership and Patent Prosecution :

The JV Company shall be bound by the IP ownership and patent prosecution provisions of the Agreement (as amended) and shall cooperate to effect such provisions. The JV Company shall cause its Affiliates and, if Total or any of its Affiliates is a subcontractor or sublicensee, Total or such Affiliate, to agree to, and shall use [*] means to require its other sublicensees and subcontractors to agree to, IP ownership provisions that assign to the JV Company ownership rights sufficient to allow the JV Company to grant to Amyris and Total, respectively, any ownership interest to which they would be entitled under the Collaboration Agreement had the IP been developed by the JV Company itself rather than by such other person or entity. With regard to the prosecution of patents for intellectual property developed by or on behalf of the JV Company and governed by the Collaboration Agreement and the prosecution of patents for such intellectual property, the JV Company, Amyris and Total shall enter into a reasonable common interest agreement, with the consent to the terms thereof not to be unreasonably withheld. Following execution of the common interest agreement, the JV Company shall have the right to participate fully in Patent Committee discussions regarding the prosecution and/or maintenance of such intellectual property. Any intellectual property developed by a JV Company Affiliate or sublicensee or any of their respective subcontractors shall be considered developed on behalf of the JV Company for purposes of this provision. Any intellectual property for which ownership is allocated to Amyris and/or Total under the Agreement shall be owned as set forth in the Agreement, subject to the licenses granted to the JV Company. Any intellectual property that is not allocated to Amyris and/or Total under the Agreement and developed by or on behalf of


[*] Certain portions denoted with an asterisk have been omitted and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested with respect to the omitted portions.













5




the JV Company shall be owned solely by the JV Company (or its designee).

To allow the JV Company to be aware of the scope of the rights licensed to it, provided that the common interest agreement has been executed, Amyris shall provide the JV Company with periodic updates regarding Inventions (including intellectual property) generated in connection with the Biofene Development Project or that specifically relate to JV Products, decisions to file (or not file) patent applications with respect to such Inventions and the status of such any intellectual property filed with respect to Inventions.

Patent Enforcement :
The JV Company shall be bound by the patent enforcement and defense provisions in the Agreement (as amended) and shall cooperate to effect such provisions; provided, however, that notwithstanding the Agreement, the following shall apply:

Amyris would have the first right (but not the obligation) to enforce any issued patent claiming the use of the JV Products in the Field, including without limitation (a) US patent No. [*] and/or US Patent No. [*] (and any foreign equivalents) or (b) any issued Patent(s) within the Collaboration IP developed by the JV Company, in each case against any Third Party infringement that would adversely affect the business of the JV Company relating to JV Products in the Field. At the request of Amyris or the JV Company, the JV Company and Amyris shall discuss means to cease any such infringement. If Amyris fails to commence a proceeding to cease any such infringement within [*] of becoming aware of such an infringement, the JV Company shall have the right to commence and control proceedings to cease any such infringement. In any such enforcement proceeding, the JV Company (or its assignee or sublicensee) or Amyris, as the case may be, shall join in any such proceeding, at the enforcing party's request and expense, or if required by applicable law. In such a case, Amyris and the JV Company shall seek to develop a litigation strategy that will [*]. For any intellectual property owned by the JV Company, the JV Company shall have the sole right to enforce and defend such intellectual property.


[*] Certain portions denoted with an asterisk have been omitted and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested with respect to the omitted portions.
















6




Other Terms :     The license agreements will include other customary terms, such as confidentiality, indemnification and dispute resolution.

During the term of the License, Amyris agrees not to commercialize, or grant a third party rights to commercialize, any isoprenoid or isoprenoid-derived compound for a Diesel Product or Jet Product.

Definitions

As per the Agreement, including the Second Amendment.

Options and License Grants from Total

Total shall be obligated to grant only the following licenses to the JV Company:  
1.
The license described in Section 9.A [hydrogenation] of the Second Amendment.

2.
The license described in Section 9.B [certification] of the Second Amendment.

3.
Under Total's and its Affiliates' interest in any Collaboration IP jointly owned by the Parties under the Agreement generated under (1) the Biofene Development Project or (2) the Renewable Diesel Product under the First Amendment, Total and its Affiliates will grant an exclusive, worldwide, [*], license to the JV Company on terms analogous to those required to be granted by Amyris to the JV Company as described above in this Exhibit (but for clarity, the non-compete applicable to Amyris described above shall not apply).

[*] Certain portions denoted with an asterisk have been omitted and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested with respect to the omitted portions.

























7




Exhibit C
Secondment Principles

Preliminary agreement on [*] potential secondees [*] and [*] alliance manager [*]
Main principles:
These [*] positions correspond to acknowledged needs of both Parties to ensure the success of the Biofene Development Project and are deemed to be filled by certain current TOTAL Secondees and additional TOTAL employees when TOTAL is ready to propose candidates for such positions. Except for the alliance manager, the preferred way to fill this position is through secondment. In some cases (related to process development activities), there might be an interim period for which TOTAL and AMYRIS will agree to have TOTAL process scientist/engineer not located in AMYRIS performing some operational missions within AMYRIS, as an integrated member of the team.
As additional needs may arise, further positions to be filled by TOTAL will be discussed on a case by case basis.
List of pre-agreed positions to be filled by TOTAL (subject to modification by agreement within the Management Committee):
Transverse
§    [*] Alliance Manager
§    [*] Project Management Officer

Biofene Development Project
§    [*] Deputy Director
§    [*] Process coordinator between R&D, process engineering and manufacturing who will also lead alternate recovery project
§    [*] Project leader on recovery/purification process (probably for jet)
§    [*] Project leader on alternative hosts
§    [*] Scientists in computational/knowledge management positions (hypothesis database, genotype mining)
§    [*] Scientists in HTS assay development related to 2nd Gen
§    [*] Chemical engineer for pilot plant operations

[*] Certain portions denoted with an asterisk have been omitted and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested with respect to the omitted portions.



1




§    [*] Fermentation scientist/engineer (at the lab or pilot - to be defined)
§    [*] Scientists in 2nd generation strain development (hypothesis design and testing, lead consolidation, HTS or evolution)

Exploratory team
The Parties agree to form the Exploratory team, as per Section 2.5 of the Collaboration Agreement, that will focus on exploratory activities outside of Biofene Development Project such as development of platform capabilities, synthetic biology tools, new hosts and new pathways; for clarity such would will be R&D Activities led under the Collaboration Agreement but not as part of the Biofene Development Project
§    [*] scientists

Payment of these [*] positions
§    As these [*] positions will be filled over a period of time, AMYRIS and TOTAL agree to share the corresponding costs (calculated based on the FTEs and TOTAL FTE rate) as follows:
o    AMYRIS will pay [*]
o    TOTAL will pay [*]
§    Process to track Secondees time and bill AMYRIS
o    Alliance manager to monitor and report to both AMYRIS and TOTAL time of Secondees (both AMYRIS- and TOTAL-paid Secondees) on a monthly basis
o    For AMYRIS-paid Secondees, TOTAL to bill AMYRIS monthly with actual costs corresponding to the Biofene Development Project (no billing of costs corresponding to activities performed by Secondees under their TOTAL time) 15 days after the end of the month, AMYRIS to make payment within 30 days of billing to TOTAL

TOTAL FTE Rate:
§    TOTAL FTE Rate will remain the on-going rate of [*] for the period from August 1, 2012 to December 31, 2012
§    TOTAL FTE Rate will be revised according to the principles of the Collaboration Agreement / Secondment Agreement (at cost) to be implemented in January 1, 2013

[*] Certain portions denoted with an asterisk have been omitted and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested with respect to the omitted portions.


2




Status of TOTAL secondees is as per the Collaboration Agreement, including:
§    TOTAL and AMYRIS jointly agree on the job description of the TOTAL Secondees
§    Once in position within AMYRIS organization, they are managed by AMYRIS
§    TOTAL can request that they spend up to [*] of their time for TOTAL and TOTAL will pay for such time

Status of the alliance manager is specific, and notably includes:
§    Reporting to TOTAL
§    Operating fully within AMYRIS organization
§    Responsible for administrative issues related to Secondees

Additional TOTAL personnel at AMYRIS
§    Additional positions at AMYRIS to be filled by TOTAL to be discussed on a case by case basis within the scope of the Biofene Development Project, or as per the Agreement
§    There may be special cases (specific skills or complementary activities) in which TOTAL offers to fund pending approval by the MC

Mechanics to track Secondees time and bill AMYRIS
§    TOTAL Alliance Manager to monitor and report to both AMYRIS and TOTAL time of Secondees (both AMYRIS and TOTAL-paid Secondees) on a monthly basis
§    For AMYRIS paid Secondees, TOTAL to bill AMYRIS monthly with actual costs (no billing of costs corresponding to activities performed by Secondees under their TOTAL time) 15 days after the end of the month, AMYRIS to make payment within 30 days of billing to TOTAL.

Job descriptions of management / coordination positions:
Project Management Officer

[*] Certain portions denoted with an asterisk have been omitted and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested with respect to the omitted portions.






3




[*]
R&D, process engineering and manufacturing Coordinator
[*]

[*] Certain portions denoted with an asterisk have been omitted and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested with respect to the omitted portions.











































4




[*]
Deputy Director Program Management
[*]

[*] Certain portions denoted with an asterisk have been omitted and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested with respect to the omitted portions.











































5




[*]
Detailed List of duties will be further defined; below is a tentative list to be refined
Weekly biofene compilation and reporting
- compile weekly Biofene dashboard
- maintain Biofene resource allocations in Resource DB
- compile weekly summary of Biofene resource usage
- personnel changes

[*] Certain portions denoted with an asterisk have been omitted and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested with respect to the omitted portions.



































6




- tank usage
- bioAnalytics experiments in queue and in progress
- KM requests in queue or in progress
- HTS usage
- ASE usage
- curate Biofene documentation trees & program management docs
- including minutes for key meetings
- manage process change tracking/notification system for Biofene operations
- manage all project documentation and quarterly planning process
- assemble and coordinate the schedule (meetings, reminders, facilitation)
- coordinate global travel schedules with CEOs, TOTAL, AMYRIS folks
- update project plan templates
- compile and distribute draft plans in quarterly planning cycles
- prepare resource request/change summaries for BSC & MC
- prepare summary of proposed portfolio changes for BSC & MC review
- finalize all project plans once approved
- confirm all resourcing changes with ProLers and Line managers
- manage XT reporting requests
- fulfill regular and ad hoc reporting requests for program & resource data
- develop templates
- compile summaries
- integrate program director & R&D President edits
- manage TOTAL reporting requests
- fulfill regular and ad hoc reporting requests
- develop templates
- aggregate information, write well structured reports
- integrate program director & R&D President edits


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- integrate TOTAL editorial feedback
- provide proofing and formatting/presentation support
- for Board of Director update presentations
- quarterly project presentations (improve uniformity of format/content/length)
- manage project close-out documentation & recognition
Quality Control and SOP
- interface with and apply tools developed by quality department
- maintain SOP documentation
- maintain process change documentation

TOTAL Alliance Manager
The job of the TOTAL Alliance Manager is to facilitate the success of the AMYRIS-TOTAL Biofene collaboration. It is a combination of management, leadership and support talents in which learning to deal with the different temperaments of people, and the unique routines, guidelines, and system of AMYRIS are critical to success. A deep understanding of the strategic vision of both companies is essential.

Duties of Alliance Manager
Responsibility for coordination of all communication between AMYRIS and TOTAL, including the establishment of systems and methods for keeping TOTAL apprised of progress on the technical and business aspects of the Collaboration.
Responsible for preparing a semi-annual report on the “state of the collaboration”, evaluating the health of the relationship with regard to communication, coordination, and management practices, with an improvement plan presented to the Management Committee at the June and December meetings.
Serves as Secretary to the Management Committee of the Collaboration, ensuring timely delivery of agendas, taking meeting minutes with action items, and scheduling all meetings.
Responsibility for hiring of seconded employees and for establishing a collaborative and efficient process for such hiring as an active member of the Talent Development and Culture Committee.
Responsibility for all billing between TOTAL and AMYRIS related to TOTAL Secondees.





8




Responsibility for active involvement in the performance review of all Secondees through direct interaction with the line manager responsible.
Responsibility in coaching and facilitating the fulfillment of duties and responsibilities of Secondees at management/coordination positions through direct interaction with the line manager responsible and/or the President of R&D.
Should the Biofene Management Committee choose to sponsor external research activities in support of the program, the Alliance Manager will serve as coordinator of these activities in all aspects- technical, financial, and legal.

Research Strategy development and execution
Together with the research leadership, contribute to the annual definition and implementation of a research roadmap to include long term (~ [*]) and short term (~ [*]) planning to support technology and product strategies
Undertake assessment of research strengths, weaknesses, opportunities and threats and develop recommendation of strategy for research including assessment of internal and external priorities, partnerships and working models
Contribute to the implementation plan for research strategy

Coaching and team building:
Serve as a partner, coach, mentor, and sounding board for research managers
Encourage a continuous drive for innovation by fostering creativity, risk-taking and engagement with the external technical community
Foster teamwork, trust and efficient communication within and between project teams
Eliminate informational or organizational barriers between projects

Contribution to AMYRIS committees : Biofene Steering Committee and Manufacturing Committee

[*] Certain portions denoted with an asterisk have been omitted and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested with respect to the omitted portions.






9




Exhibit D
Transparency

AMYRIS will provide to TOTAL information and means to get such information as follows:
§    TOTAL to get access to all information (including results) related to Biofene Development Project in full transparency
§    AMYRIS to share all the internal reports related to Biofene Development Project with TOTAL
§    AMYRIS to give access to all AMYRIS internal meetings related to Biofene Development Project, through the invitation of TOTAL Secondees.
For such purpose, AMYRIS will give access to existing material and TOTAL Secondees will be responsible for any reformatting and distribution to TOTAL of material.



















1




Exhibit E
Activities of Biojet Development Program before September 30, 2012

The activities of the Biojet Development Program will focus on delivering a report by August 5, 2012 including:
[*]
Based on this report, the Joint Steering Committee and the Management Committee will decide on the way forward based on:
o    Technical review of the report
o    Patentability review


[*] Certain portions denoted with an asterisk have been omitted and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested with respect to the omitted portions.

































1



 
 
Exhibit 31.01
CERTIFICATION OF CHIEF EXECUTIVE OFFICER
 
PURSUANT TO RULE 13a-14(c) and 15d-14(a) OF THE SECURITIES EXCHANGE ACT OF 1934
 
I, John Melo, certify that:
1.
I have reviewed this Quarterly Report on Form 10-Q of Amyris, Inc.;
2.
Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this report;
3.
Based on my knowledge, the financial statements, and other financial information included in this report, fairly present in all material respects the financial condition, results of operations and cash flows of the registrant as of, and for, the periods presented in this report;
4.
The registrant's other certifying officer and I are responsible for establishing and maintaining disclosure controls and procedures (as defined in Exchange Act Rules 13a-15(e) and 15d-15(e)) and internal control over financial reporting (as defined in Exchange Act Rules 13a-15(f) and 15d-15(f)) for the registrant and have:
a)
Designed such disclosure controls and procedures, or caused such disclosure controls and procedures to be designed under our supervision, to ensure that material information relating to the registrant, including its consolidated subsidiaries, is made known to us by others within those entities, particularly during the period in which this report is being prepared;
b)
Designed such internal control over financial reporting, or caused such internal control over financial reporting to be designed under our supervision, to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external purposes in accordance with generally accepted accounting principles;
c)
Evaluated the effectiveness of the registrant's disclosure controls and procedures and presented in this report our conclusions about the effectiveness of the disclosure controls and procedures, as of the end of the period covered by this report based on such evaluation; and
d)
Disclosed in this report any change in the registrant's internal control over financial reporting that occurred during the registrant's most recent fiscal quarter (the registrant's fourth fiscal quarter in the case of an annual report) that has materially affected, or is reasonably likely to materially affect, the registrant's internal control over financial reporting; and
5.
The registrant's other certifying officer and I have disclosed, based on our most recent evaluation of internal control over financial reporting, to the registrant's auditors and the audit committee of the registrant's board of directors (or persons performing the equivalent functions):
a)
All significant deficiencies and material weaknesses in the design or operation of internal control over financial reporting which are reasonably likely to adversely affect the registrant's ability to record, process, summarize and report financial information; and
b)
Any fraud, whether or not material, that involves management or other employees who have a significant role in the registrant's internal control over financial reporting.
 
 
 
 
 
 
Date:
November 8, 2012
 
 
/s/ JOHN MELO
 
 
 
 
John Melo
 
 
 
 
President and Chief Executive Officer




  

Exhibit 31.02
CERTIFICATION OF CHIEF FINANCIAL OFFICER
 
PURSUANT TO RULE 13a-14(c) and 15d-14(a) OF THE SECURITIES EXCHANGE ACT OF 1934
 
I, Steven R. Mills, certify that:
1.
I have reviewed this Quarterly Report on Form 10-Q of Amyris, Inc.;
2.
Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this report;
3.
Based on my knowledge, the financial statements, and other financial information included in this report, fairly present in all material respects the financial condition, results of operations and cash flows of the registrant as of, and for, the periods presented in this report;
4.
The registrant's other certifying officer and I are responsible for establishing and maintaining disclosure controls and procedures (as defined in Exchange Act Rules 13a-15(e) and 15d-15(e)) and internal control over financial reporting (as defined in Exchange Act Rules 13a-15(f) and 15d-15(f)) for the registrant and have:
a)
Designed such disclosure controls and procedures, or caused such disclosure controls and procedures to be designed under our supervision, to ensure that material information relating to the registrant, including its consolidated subsidiaries, is made known to us by others within those entities, particularly during the period in which this report is being prepared;
b)
Designed such internal control over financial reporting, or caused such internal control over financial reporting to be designed under our supervision, to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external purposes in accordance with generally accepted accounting principles;
c)
Evaluated the effectiveness of the registrant's disclosure controls and procedures and presented in this report our conclusions about the effectiveness of the disclosure controls and procedures, as of the end of the period covered by this report based on such evaluation; and
d)
Disclosed in this report any change in the registrant's internal control over financial reporting that occurred during the registrant's most recent fiscal quarter (the registrant's fourth fiscal quarter in the case of an annual report) that has materially affected, or is reasonably likely to materially affect, the registrant's internal control over financial reporting; and
5.
The registrant's other certifying officer and I have disclosed, based on our most recent evaluation of internal control over financial reporting, to the registrant's auditors and the audit committee of the registrant's board of directors (or persons performing the equivalent functions):
a)
All significant deficiencies and material weaknesses in the design or operation of internal control over financial reporting which are reasonably likely to adversely affect the registrant's ability to record, process, summarize and report financial information; and
b)
Any fraud, whether or not material, that involves management or other employees who have a significant role in the registrant's internal control over financial reporting.
 
 
 
 
 
 
Date:
November 8, 2012
 
 
/s/    STEVEN R. MILLS  
 
 
 
 
Steven R. Mills
 
 
 
 
Chief Financial Officer




 

 
Exhibit 32.01
Certification of CEO Furnished Pursuant to 18 U.S.C. Section 1350,
As Adopted Pursuant To
Section 906 of The Sarbanes-Oxley Act of 2002
 
In connection with the Quarterly Report of Amyris, Inc. (the “Company”) on Form 10-Q for the quarterly period ended September 30, 2012, as filed with the Securities and Exchange Commission on the date hereof, I, John Melo, Chief Executive Officer of the Company, certify for the purposes of section 1350 of chapter 63 of title 18 of the United States Code, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002, that, to the best of my knowledge,
(i) the Quarterly Report of the Company on Form 10-Q for the quarterly period ended September 30, 2012 (the “Report”), fully complies with the requirements of section 13(a) or 15(d) of the Securities Exchange Act of 1934, and
(ii) the information contained in the Report fairly presents, in all material respects, the financial condition and results of operations of the Company.
 
 
 
 
 
 
Date:
November 8, 2012
 
 
/s/    JOHN MELO
 
 
 
 
 
John Melo
 
 
 
 
President and Chief Executive Officer
 
 
 
 
(Principal Executive Officer)
 





 

 
Exhibit 32.02
Certification of CFO Furnished Pursuant to 18 U.S.C. Section 1350,
As Adopted Pursuant To
Section 906 of The Sarbanes-Oxley Act of 2002
 
In connection with the Quarterly Report of Amyris, Inc. (the “Company”) on Form 10-Q for the quarterly period ended September 30, 2012, as filed with the Securities and Exchange Commission on the date hereof, I, Steven R. Mills, Chief Financial Officer of the Company, certify for the purposes of section 1350 of chapter 63 of title 18 of the United States Code, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002, that, to the best of my knowledge,
(i) the Quarterly Report of the Company on Form 10-Q for the quarterly period ended September 30, 2012 (the “Report”), fully complies with the requirements of section 13(a) or 15(d) of the Securities Exchange Act of 1934, and
(ii) the information contained in the Report fairly presents, in all material respects, the financial condition and results of operations of the Company.
 
 
 
 
 
 
Date:
November 8, 2012
 
 
/s/    STEVEN R. MILLS
 
 
 
 
Steven R. Mills
 
 
 
 
Chief Financial Officer
 
 
 
 
(Principal Financial Officer)