First Trust Exchange-Traded Fund VI

Annual Report

March 31, 2020

Shareholder Letter	2
Market Overview	3
Fund Performance Overview
First Trust Nasdaq Bank ETF (FTXO)	5
First Trust Nasdaq Food & Beverage ETF (FTXG)	7
First Trust Nasdaq Oil & Gas ETF (FTXN)	9
First Trust Nasdaq Pharmaceuticals ETF (FTXH)	11
First Trust Nasdaq Retail ETF (FTXD)	13
First Trust Nasdaq Semiconductor ETF (FTXL)	15
First Trust Nasdaq Transportation ETF (FTXR)	17
Notes to Fund Performance Overview	19
Understanding Your Fund Expenses	20
Portfolio of Investments
First Trust Nasdaq Bank ETF (FTXO)	22
First Trust Nasdaq Food & Beverage ETF (FTXG)	23
First Trust Nasdaq Oil & Gas ETF (FTXN)	24
First Trust Nasdaq Pharmaceuticals ETF (FTXH)	25
First Trust Nasdaq Retail ETF (FTXD)	26
First Trust Nasdaq Semiconductor ETF (FTXL)	27
First Trust Nasdaq Transportation ETF (FTXR)	28
Statements of Assets and Liabilities	30
Statements of Operations	32
Statements of Changes in Net Assets	34
Financial Highlights	37
Notes to Financial Statements	44
Report of Independent Registered Public Accounting Firm	51
Additional Information	52
Board of Trustees and Officers	55
Privacy Policy	57

Caution Regarding Forward-Looking Statements

This report contains certain forward-looking statements within the meaning of the Securities Act of 1933, as amended, and the Securities Exchange Act of 1934, as amended. Forward-looking statements include statements regarding the goals, beliefs, plans or current expectations of First Trust Advisors L.P. (“First Trust” or the “Advisor”) and its representatives, taking into account the information currently available to them. Forward-looking statements include all statements that do not relate solely to current or historical fact. For example, forward-looking statements include the use of words such as “anticipate,” “estimate,” “intend,” “expect,” “believe,” “plan,” “may,” “should,” “would” or other words that convey uncertainty of future events or outcomes.

Forward-looking statements involve known and unknown risks, uncertainties and other factors that may cause the actual results, performance or achievements of any series of First Trust Exchange-Traded Fund VI (the “Trust”) described in this report (each such series is referred to as a “Fund” and collectively, the “Funds”) to be materially different from any future results, performance or achievements expressed or implied by the forward-looking statements. When evaluating the information included in this report, you are cautioned not to place undue reliance on these forward-looking statements, which reflect the judgment of the Advisor and its representatives only as of the date hereof. We undertake no obligation to publicly revise or update these forward-looking statements to reflect events and circumstances that arise after the date hereof.

Performance and Risk Disclosure

There is no assurance that any Fund described in this report will achieve its investment objective. Each Fund is subject to market risk, which is the possibility that the market values of securities owned by the Fund will decline and that the value of the Fund’s shares may therefore be less than what you paid for them. Accordingly, you can lose money by investing in a Fund. See “Risk Considerations” in the Additional Information section of this report for a discussion of certain other risks of investing in the Funds.

Performance data quoted represents past performance, which is no guarantee of future results, and current performance may be lower or higher than the figures shown. For the most recent month-end performance figures, please visit www.ftportfolios.com or speak with your financial advisor. Investment returns, net asset value and share price will fluctuate and Fund shares, when sold, may be worth more or less than their original cost.

The Advisor may also periodically provide additional information on Fund performance on each Fund’s web page at www.ftportfolios.com.

How to Read This Report

This report contains information that may help you evaluate your investment. It includes details about each Fund and presents data and analysis that provide insight into each Fund’s performance and investment approach.

By reading the market overview by Robert F. Carey, Chief Market Strategist of the Advisor, you may obtain an understanding of how the market environment affected the performance of each Fund. The statistical information that follows may help you understand each Fund’s performance compared to that of relevant market benchmarks.

It is important to keep in mind that the opinions expressed by personnel of the Advisor are just that: informed opinions. They should not be considered to be promises or advice. The opinions, like the statistics, cover the period through the date on the cover of this report. The material risks of investing in each Fund are spelled out in the prospectus, the statement of additional information, and other Fund regulatory filings.

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First Trust Exchange-Traded Fund VI

Annual Letter from the Chairman and CEO

March 31, 2020

Dear Shareholders,

First Trust is pleased to provide you with the annual report for certain series of the First Trust Exchange-Traded Fund VI (the “Funds”), which contains detailed information about the Funds for the twelve months ended March 31, 2020.

I am sorry to report that the coronavirus (COVID-19) pandemic is still dominating our daily lives, the economy and securities markets. Many of us have learned the hard way that it is no fun sheltering in place for weeks on end, and by hard way I mean at the behest of state and local government officials. It is also not fun being furloughed from a job or losing a job outright for reasons beyond one’s control. As President Donald J. Trump has repeatedly said, the cure cannot be worse than the problem itself. For those who do not follow the news closely, the governors of Georgia, South Carolina, Tennessee and Texas announced on or about April 20, 2020, that they intend to open some “nonessential” businesses by early May. If nothing else, these could prove to be valuable test cases for the rest of the states trying to strike a balance between fighting COVID-19 and curbing the economic fallout stemming from the virus. While we certainly trumpet the call for health and safety first, we also realize that we need to find a way to get Americans back to work.

Suffice it to say that this virus is proving to be plenty stubborn. While I tend to be largely U.S.-centric, it does not escape me that this fight is global in scope. We now have proof that the virus can flare up again after seemingly being mitigated. Singapore, which had been credited with having a successful blueprint for curbing the spread of the virus, reported that it experienced back-to-back days of more than 1,000 new cases in the third week of April. As a result, it has extended its partial lockdown strategy another four weeks. COVID-19 impacts business dealings at every level, especially the C-suite. Refinitiv, a global provider of financial market data, reported that global mergers and acquisitions deal activity totaled $762.6 billion year-to-date through April 17, 2020, down 33% from the same period a year ago, according to Reuters. The number of deals declined by 20%. A recent survey by EY of more than 2,900 executives worldwide found that 56% of them, despite the current crisis, are still planning an acquisition in the next 12 months. The takeaway here is that, despite having to navigate unchartered waters, more than one out of two executives are looking to grow their companies over the next 12 months. I’ll take that ratio in this climate. At First Trust Advisors L.P., we have always believed in the traditional buy-and-hold philosophy of investing. Investors should strongly consider shifting their focus away from the next two quarters, which are likely to be dismal, to what potentially lies beyond – a full-on recovery, in our opinion.

The Federal Reserve, Treasury Department and Congress are all working with the Trump Administration to pull together trillions of dollars of aid and stimulus to help prop up workers, companies and municipalities in this time of need. Health Care companies have ramped up their efforts to develop and manufacture much needed testing equipment, medical supplies and therapeutics. Hopefully, at some point in the near-future, one or more of these companies will deliver us a present in the form of a vaccine.

Both the equity and debt markets in the U.S. have responded favorably to the enormous financial support from the Federal government. The government has responded faster and more robustly to the current crisis than it did in the 2008-2009 financial crisis. While still down, stock and bond valuations have rebounded significantly from their lows reached in late March. We remain optimistic about the second half of 2020 and 2021. Stay the course.

Thank you for giving First Trust the opportunity to play a role in your financial future. We value our relationship with you and will report on the Funds again in six months.

Sincerely,

James A. Bowen

Chairman of the Board of Trustees

Chief Executive Officer of First Trust Advisors L.P.

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First Trust Exchange-Traded Fund VI

Annual Report

March 31, 2020 (Unaudited)

Robert F. Carey, CFA

Senior Vice President and Chief Market Strategist

First Trust Advisors L.P.

Mr. Carey is responsible for the overall management of research and analysis of the First Trust product line. Mr. Carey has over 27 years of experience as an Equity and Fixed-Income Analyst and is a recipient of the Chartered Financial Analyst (“CFA”) designation. He is a graduate of the University of Illinois at Champaign- Urbana with a B.S. in Physics. He is also a member of the Investment Analysts Society of Chicago and the CFA Institute. Mr. Carey has appeared as a guest on such programs as Bloomberg TV, CNBC, and WBBM Radio, and has been quoted by several publications, including The Wall Street Journal, The Wall Street Reporter, Bloomberg News Service, and Registered Rep.

State of the Global Economy

The onset of the coronavirus (COVID-19) pandemic has inflicted tremendous damage on the global economy. It single-handedly brought an end to the bull market in stocks in the first quarter of 2020 (see below), although that nearly happened in the fourth quarter of 2018. At this time, we don’t know how long it will take for the virus to run its course or for a vaccine to become available for the masses. History suggests that vaccines take roughly 18 months to win approval and go to market, but some are hoping for closer to 12 months this time around. Perhaps an existing drug will be proven effective against the virus.

The International Monetary Fund (“IMF”) has characterized the quarantine and social distancing efforts accompanying the COVID-19 pandemic as the “Great Lockdown.” No country has been spared. The IMF adjusted its global economic growth projections following the end of the first quarter of 2020. It now sees world real gross domestic product (“GDP”) growth declining by 3.0% in 2020, down over six percentage points from its 3.3% growth projection prior to the onset of the virus. Provided the pandemic fades in the second half of 2020, the IMF sees the growth rate rising by 5.8% in 2021. U.S. real GDP growth is projected to be down 5.9% in 2020, but up 4.7% in 2021. Emerging Markets and Developing Nations are expected to come in at 1.0% in 2020 and 8.5% in 2021.

In addition to the COVID-19 developments, investors should also be aware that, despite the Phase One trade deal signed with China in January 2020, there is still an ongoing trade conflict between the U.S. and China, and who knows if the virus might eventually get folded into the battle since it reportedly first surfaced in China in the fourth quarter of 2019. President Donald J. Trump has driven home this point at more than one of his press briefings. The Trump Administration’s implementation of tariffs, particularly against China, has been operational for 24 months and counting.

Global Equities Markets

For the 12-month period ended March 31, 2020, the MSCI World ex USA and MSCI Emerging Markets Indices posted total returns of -14.89% (USD) and -17.69% (USD), respectively, according to Bloomberg. Over that same period, the U.S. dollar appreciated 1.82% against a basket of major currencies, as measured by the U.S. Dollar Index (DXY). The slight gain in the dollar likely had just a small drag on the performance of the two foreign stock indices during the period, in our opinion. With respect to U.S. equities, the S&P 500^®, S&P MidCap 400^® and S&P SmallCap 600^® Indices posted total returns of -6.98%, -22.51% and -25.89%, respectively, over the past 12 months. Large-capitalization (cap) stocks clearly outperformed their mid- and small-cap counterparts as investors sought to reduce their risk exposure due to the escalation in the trade war between the U.S. and China and the onset of COVID-19 in the first quarter of 2020, in our opinion. Ten of the 11 sectors that comprise the S&P 500^® Index were down on a total return basis for the same period. The top performer for the period was Information Technology, up 10.43%, while the worst result by far came from Energy, down 52.42%.

The S&P 500^® Index closed at 2,584.59 on March 31, 2020, 23.67% below its all-time closing high of 3,386.15 on February 19, 2020, according to Bloomberg. The nearly 11-year bull market was no more. The S&P 500^® Index was now in bear market territory. A bear market entails a price decline of 20% or more from the most recent high. Data from Goldman Sachs and CNBC indicates that the average bear market since WWII has generated an average loss of 30.4%, has lasted 13 months and taken 21.9 months on average to recover. A Bloomberg survey of 19 equity strategists found that their average 2020 year-end price target for the S&P 500^® Index was 3,039 as of March 26, 2020, according to its own release. The highest estimate was 3,500 while the lowest estimate was 2,650. Keep in mind, earnings and revenue projections may become harder to come by in the months ahead if more and more companies choose to suspend guidance.

Investors liquidated an estimated net $78.44 billion from U.S. Equity mutual funds and exchange-traded funds (“ETFs”) for the 12-month period ended March 31, 2020, according to Morningstar. International Equity mutual funds and ETFs, however, took in an estimated net $7.36 billion over the same period. Investors continue to favor passive over active funds. Passive U.S. Equity mutual funds and ETFs reported estimated net inflows totaling $180.37 billion in the period, compared to estimated net outflows for active U.S. Equity mutual funds and ETFs totaling $258.81 billion. Passive International Equity mutual funds and ETFs reported estimated

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net inflows totaling $73.19 billion for the same period, compared to estimated net outflows for active International Equity mutual funds and ETFs totaling $65.83 billion.

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First Trust Nasdaq Bank ETF (FTXO)

The First Trust Nasdaq Bank ETF (the “Fund”) seeks investment results that correspond generally to the price and yield (before the Fund’s fees and expenses) of an equity index called the Nasdaq US Smart Banks Index (the “Index”). The shares of the Fund are listed and trade on The Nasdaq Stock Market LLC under the ticker symbol “FTXO.” The Fund will normally invest at least 90% of its net assets (including investment borrowings) in the common stocks and depositary receipts that comprise the Index. The Index is owned and is developed, maintained and sponsored by Nasdaq, Inc. (the “Index Provider”).

The Index is designed to provide exposure to U.S. companies comprising the banking sector that have been selected based upon their liquidity and weighted based upon their cumulative score on three investing factors: volatility, value and growth. The Index’s initial selection universe consists of the component securities of the NASDAQ US Benchmark Index that have been classified as comprising the banking sector according to the Industry Classification Benchmark. The NASDAQ US Benchmark Index is an index seeking to track the performance of small, mid and large capitalization U.S. companies. This classification includes companies providing a broad range of financial services, including retail banking, loans and money transmissions.

The Fund generated a net asset value (“NAV”) return of -33.93% during the period covered by this report. During the same period, the NASDAQ US Benchmark Index (“Benchmark”) generated a return of -8.86%. The Fund invested entirely in the Banking industry in the Financials sector. The Fund significantly underperformed the Benchmark. The Banking industry securities in the Benchmark performed worse than the Benchmark as a whole, so the Fund underperformed due to the allocation effect to this industry. The investments in the Banking industry in the Fund performed -8.9% worse, on average, than the Banking investments in the Benchmark, so the Fund also underperformed due to the selection effect. The only sources of outperformance for the Fund came simply from not allocating any investments to some of the other poor-performing sectors. The most notable of these is the Energy sector. The lack of investments in the Energy sector earned 1.6% of outperformance for the Fund versus the Benchmark.

Nasdaq^® and Nasdaq US Smart Banks Index (“the Nasdaq Indexes”) are registered trademarks and service marks of Nasdaq, Inc. (together with its affiliates hereinafter referred to as the “Corporations”) and are licensed for use by First Trust. The Fund has not been passed on by the Corporations as to its legality or suitability. The Fund is not issued, endorsed, sold or promoted by the Corporations. THE CORPORATIONS MAKE NO WARRANTIES AND BEAR NO LIABILITY WITH RESPECT TO THE FUND.

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First Trust Nasdaq Food & Beverage ETF (FTXG)

The First Trust Nasdaq Food & Beverage ETF (the “Fund”) seeks investment results that correspond generally to the price and yield (before the Fund’s fees and expenses) of an equity index called the Nasdaq US Smart Food & Beverage Index (the “Index”). The shares of the Fund are listed and trade on The Nasdaq Stock Market LLC under the ticker symbol “FTXG.” The Fund will normally invest at least 90% of its net assets (including investment borrowings) in the common stocks and depositary receipts that comprise the Index. The Index is owned and is developed, maintained and sponsored by Nasdaq, Inc. (the “Index Provider”).

The Index is designed to provide exposure to U.S. companies comprising the food and beverage sector that have been selected based upon their liquidity and weighted based upon their cumulative score on three investing factors: volatility, value and growth. The Index’s initial selection universe consists of the component securities of the NASDAQ US Benchmark Index that have been classified as comprising either the beverages sector or food producers sector according to the Industry Classification Benchmark. The NASDAQ US Benchmark Index is an index seeking to track the performance of small, mid and large capitalization U.S. companies. These classifications include: (i) manufacturers and shippers of cider or malt products; (ii) producers, distillers, vintners, blenders and shippers of wine and spirits; (iii) manufacturers, bottlers and distributors of non-alcoholic beverages; (iv) companies that grow crops or raise livestock, operate fisheries or own non-tobacco plantations; (v) food producers, including meatpacking, snacks, fruits, vegetables, dairy products and frozen seafood; (vi) producers of pet food; and (vii) manufacturers of dietary supplements, vitamins and related items.

The Fund generated a NAV return of -12.69% during the period covered by this report. During the same period, the NASDAQ US Benchmark Index (“Benchmark”) generated a return of -8.86%. The Fund allocated almost exclusively to the Consumer Staples sector during the period, predominately in the Food, Beverage, & Tobacco industry, but also across the Food & Staples Retailing as well as Household & Personal Products industries. The allocation to Food, Beverage, & Tobacco was 90.7% and caused -6.2% total return to the Fund. The Food & Staples Retailing received only 5.8% allocation, but, due to performance of -49.3%, contributed -4.3% to the Fund’s return. On a relative basis, the Fund underperformed the Benchmark. The most underperformance for the Fund came from the poor-performing Food & Staples Retailing industry, which caused -3.7% of relative performance for the Fund. The Fund earned the most outperformance against the Benchmark by not allocating to the Energy sector. The investments in this sector were a drag on the Index and this caused 2.2% of outperformance for the Fund versus the Benchmark.

Nasdaq^® and Nasdaq US Smart Food & Beverage Index (“the Nasdaq Indexes”) are registered trademarks and service marks of Nasdaq, Inc. (together with its affiliates hereinafter referred to as the “Corporations”) and are licensed for use by First Trust. The Fund has not been passed on by the Corporations as to its legality or suitability. The Fund is not issued, endorsed, sold or promoted by the Corporations. THE CORPORATIONS MAKE NO WARRANTIES AND BEAR NO LIABILITY WITH RESPECT TO THE FUND.

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First Trust Nasdaq Oil & Gas ETF (FTXN)

The First Trust Nasdaq Oil & Gas ETF (the “Fund”) seeks investment results that correspond generally to the price and yield (before the Fund’s fees and expenses) of an equity index called the Nasdaq US Smart Oil & Gas Index (the “Index”). The shares of the Fund are listed and trade on The Nasdaq Stock Market LLC under the ticker symbol “FTXN.” The Fund will normally invest at least 90% of its net assets (including investment borrowings) in the common stocks and depositary receipts that comprise the Index. The Index is owned and is developed, maintained and sponsored by Nasdaq, Inc. (the “Index Provider”).

The Index is designed to provide exposure to U.S. companies comprising the oil and gas sector that have been selected based upon their liquidity and weighted based upon their cumulative score on three investing factors: volatility, value and growth. The Index’s initial selection universe consists of the component securities of the NASDAQ US Benchmark Index that have been classified as comprising either the oil & gas producers sector or the oil equipment, services & distribution sector according to the Industry Classification Benchmark. The NASDAQ US Benchmark Index is an index seeking to track the performance of small, mid and large capitalization U.S. companies. These classifications include: (i) companies engaged in the exploration for and drilling, production, refining and supply of oil and gas products; (ii) integrated oil and gas companies engaged in the exploration for, and drilling, production, refining, distribution and retail sales of, oil and gas products; (iii) suppliers of equipment and services to oil fields and offshore platforms, such as drilling, exploration, seismic-information services and platform construction; and (iv) operators of pipelines carrying oil, gas or other forms of fuel.

The Fund generated a NAV return of -56.26% during the period covered by this report. During the same period, the NASDAQ US Benchmark Index (“Benchmark”) generated a return of -8.86%. The Fund invested 90.0% in the Energy sector, which performed poorly during the year, contributing -53.1% to the Fund’s return. On a relative basis, the Fund underperformed the Benchmark. The investments in Energy caused -41.4% of underperformance for the Fund versus the Benchmark. The greatest source of outperformance for the Fund came by simply not investing in the Financials market, an allocation which earned 1.1% of outperformance for the Fund.

Nasdaq^® and Nasdaq US Smart Oil & Gas Index (“the Nasdaq Indexes”) are registered trademarks and service marks of Nasdaq, Inc. (together with its affiliates hereinafter referred to as the “Corporations”) and are licensed for use by First Trust. The Fund has not been passed on by the Corporations as to its legality or suitability. The Fund is not issued, endorsed, sold or promoted by the Corporations. THE CORPORATIONS MAKE NO WARRANTIES AND BEAR NO LIABILITY WITH RESPECT TO THE FUND.

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First Trust Nasdaq Pharmaceuticals ETF (FTXH)

The First Trust Nasdaq Pharmaceuticals ETF (the “Fund”) seeks investment results that correspond generally to the price and yield (before the Fund’s fees and expenses) of an equity index called the Nasdaq US Smart Pharmaceuticals Index (the “Index”). The shares of the Fund are listed and trade on The Nasdaq Stock Market LLC under the ticker symbol “FTXH.” The Fund will normally invest at least 90% of its net assets (including investment borrowings) in the common stocks and depositary receipts that comprise the Index. The Index is owned and is developed, maintained and sponsored by Nasdaq, Inc. (the “Index Provider”).

The Index is designed to provide exposure to U.S. companies comprising the pharmaceutical sector that have been selected based upon their liquidity and weighted based upon their cumulative score on three investing factors: volatility, value and growth. The Index’s initial selection universe consists of the component securities of the NASDAQ US Benchmark Index that have been classified as comprising the pharmaceuticals sub-sector according to the Industry Classification Benchmark. The NASDAQ US Benchmark Index is an index seeking to track the performance of small, mid and large capitalization U.S. companies. This classification includes vaccine producers and manufacturers of prescription or over-the-counter drugs.

The Fund generated a NAV return of -9.13% during the period covered by this report. During the same period, the NASDAQ US Benchmark Index (“Benchmark”) generated a return of -8.86%. The Fund’s investments were largely focused in the Health Care sector, with 91.3% in the Pharmaceuticals Biotechnology & Life Sciences industry. These investments caused -12.5% contribution to the Fund’s total return. The investments in the Health Care Equipment & Services industry received 6.0% allocation and caused 0.4% contribution to the Fund’s return. On a relative basis, the Fund underperformed the Benchmark. The bulk of the underperformance came from the Health Care sector, which caused -4.1% of underperformance versus the Benchmark. The Fund earned the most outperformance by allocating nothing to the Energy sector, an allocation which caused 2.3% of outperformance for the Fund.

Nasdaq^® and Nasdaq US Smart Pharmaceuticals Index (“the Nasdaq Indexes”) are registered trademarks and service marks of Nasdaq, Inc. (together with its affiliates hereinafter referred to as the “Corporations”) and are licensed for use by First Trust. The Fund has not been passed on by the Corporations as to its legality or suitability. The Fund is not issued, endorsed, sold or promoted by the Corporations. THE CORPORATIONS MAKE NO WARRANTIES AND BEAR NO LIABILITY WITH RESPECT TO THE FUND.

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First Trust Nasdaq Retail ETF (FTXD)

The First Trust Nasdaq Retail ETF (the “Fund”) seeks investment results that correspond generally to the price and yield (before the Fund’s fees and expenses) of an equity index called the Nasdaq US Smart Retail Index (the “Index”). The shares of the Fund are listed and trade on The Nasdaq Stock Market LLC under the ticker symbol “FTXD.” The Fund will normally invest at least 90% of its net assets (including investment borrowings) in the common stocks and depositary receipts that comprise the Index. The Index is owned and is developed, maintained and sponsored by Nasdaq, Inc. (the “Index Provider”).

The Index is designed to provide exposure to U.S. companies comprising the retail sector that have been selected based upon their liquidity and weighted based upon their cumulative score on three investing factors: volatility, value and growth. The Index’s initial selection universe consists of the component securities of the NASDAQ US Benchmark Index that have been classified as comprising either the food & drug retailers sector or the general retailers sector according to the Industry Classification Benchmark. The NASDAQ US Benchmark Index is an index seeking to track the performance of small, mid and large capitalization U.S. companies. This classification includes: (i) operators of pharmacies, including wholesalers and distributors catering to these businesses; (ii) supermarkets, food-oriented convenience stores and other food retailers and distributors; (iii) retailers and wholesalers specializing mainly in clothing, shoes, jewelry, sunglasses and other accessories; (iv) retail outlets and wholesalers; (v) retailers and wholesalers concentrating on the sale of home improvement products; (vi) providers of consumer services such as online marketplaces, auction houses, day-care centers, dry cleaners, schools, consumer rental companies, veterinary clinics, hair salons and providers of funerals, lawn maintenance, consumer storage, heating and cooling installation and plumbing services; and (vii) retailers and wholesalers concentrating on a single class of goods, such as electronics, books, automotive parts or closeouts.

The Fund generated a NAV return of -17.90% during the period covered by this report. During the same period, the NASDAQ US Benchmark Index (“Benchmark”) generated a return of -8.86%. During the period, the Fund allocated 63.1% to the Retail industry in the Consumer Discretionary sector and 24.8% to the Food & Staples Retailing industry in the Consumer Staples sector. In total, investments in Consumer Discretionary contributed -15.0% to the Fund’s return and investments in Consumer Staples contributed -1.5% to the Fund’s return. The Fund also had minimal exposure to other sectors. The only positively contributing sector during the period were the investments in Communication Services which received 0.4% allocation and contributed 0.04% to the Fund’s return. On a relative basis, the Fund underperformed the Benchmark. The most underperformance for the Fund versus the Benchmark came from the sector with the greatest weight, the Consumer Discretionary sector. This sector caused -10.5% of underperformance for the Fund versus the Benchmark. The sector with the most outperformance for the Fund was the Energy sector. The Fund did not allocate any investments to this sector during the period, which performed poorly during the year. This earned 2.1% of outperformance for the Fund versus the Benchmark.

Nasdaq^® and Nasdaq US Smart Retail Index (“the Nasdaq Indexes”) are registered trademarks and service marks of Nasdaq, Inc. (together with its affiliates hereinafter referred to as the “Corporations”) and are licensed for use by First Trust. The Fund has not been passed on by the Corporations as to its legality or suitability. The Fund is not issued, endorsed, sold or promoted by the Corporations. THE CORPORATIONS MAKE NO WARRANTIES AND BEAR NO LIABILITY WITH RESPECT TO THE FUND.

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First Trust Nasdaq Retail ETF (FTXD) (Continued)

Sector Allocation	% of Total Investments
Consumer Discretionary	56.1%
Consumer Staples	34.7
Health Care	4.8
Industrials	4.0
Communication Services	0.4
Total	100.0%

Top Ten Holdings	% of Total Investments
Kroger (The) Co.	11.5%
Walmart, Inc.	10.0
Target Corp.	6.5
Sysco Corp.	5.9
AutoZone, Inc.	5.8
Costco Wholesale Corp.	5.0
Home Depot (The), Inc.	4.4
Dollar General Corp.	4.2
CVS Health Corp.	4.1
TJX (The) Cos., Inc.	4.1
Total	61.5%

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First Trust Nasdaq Semiconductor ETF (FTXL)

The First Trust Nasdaq Semiconductor ETF (the “Fund”) seeks investment results that correspond generally to the price and yield (before the Fund’s fees and expenses) of an equity index called the Nasdaq US Smart Semiconductor Index (the “Index”). The shares of the Fund are listed and trade on The Nasdaq Stock Market LLC under the ticker symbol “FTXL.” The Fund will normally invest at least 90% of its net assets (including investment borrowings) in the common stocks and depositary receipts that comprise the Index. The Index is owned and is developed, maintained and sponsored by Nasdaq, Inc. (the “Index Provider”).

The Index is designed to provide exposure to U.S. companies comprising the semiconductor sector that have been selected based upon their liquidity and weighted based upon their cumulative score on three investing factors: volatility, value and growth. The Index’s initial selection universe consists of the component securities of the NASDAQ US Benchmark Index that have been classified as comprising the semiconductors sub-sector according to the Industry Classification Benchmark. The NASDAQ US Benchmark Index is an index seeking to track the performance of small, mid and large capitalization U.S. companies. This classification includes producers and distributors of semiconductors and other integrated chips, including other products related to the semiconductor industry, such as semiconductor capital equipment and motherboards.

The Fund generated a NAV return of 4.82% during the period covered by this report. During the same period, the NASDAQ US Benchmark Index (“Benchmark”) generated a return of -8.86%. The Fund earned a positive return from its focus in the Semiconductors & Semiconductor Equipment industry. This industry received an allocation of 95.7% and contributed 7.2% to the Fund’s total return. Investments in the Technology Hardware & Equipment industry, however, contributed negatively to the Fund, causing -1.7% of drag in the portfolio. Both of these industries are in the Information Technology sector. On a relative basis, the Fund outperformed the Benchmark. The most outperformance came from investments in Semiconductors & Semiconductor Equipment, which earned 17.7% outperformance for the Fund. Meanwhile, investments in the Technology Hardware & Equipment industry caused -3.0% of underperformance for the Fund versus the Benchmark during the period.

Nasdaq^® and Nasdaq US Smart Semiconductor Index (“the Nasdaq Indexes”) are registered trademarks and service marks of Nasdaq, Inc. (together with its affiliates hereinafter referred to as the “Corporations”) and are licensed for use by First Trust. The Fund has not been passed on by the Corporations as to its legality or suitability. The Fund is not issued, endorsed, sold or promoted by the Corporations. THE CORPORATIONS MAKE NO WARRANTIES AND BEAR NO LIABILITY WITH RESPECT TO THE FUND.

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First Trust Nasdaq Semiconductor ETF (FTXL) (Continued)

Sector Allocation	% of Total Investments
Information Technology	100.0%
Total	100.0%

Top Ten Holdings	% of Total Investments
Entegris, Inc.	8.7%
Intel Corp.	8.6
Skyworks Solutions, Inc.	8.4
Maxim Integrated Products, Inc.	7.9
Qorvo, Inc.	7.1
Cirrus Logic, Inc.	4.2
Lam Research Corp.	4.1
KLA Corp.	4.0
Teradyne, Inc.	4.0
Texas Instruments, Inc.	3.8
Total	60.8%

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First Trust Nasdaq Transportation ETF (FTXR)

The First Trust Nasdaq Transportation ETF (the “Fund”) seeks investment results that correspond generally to the price and yield (before the Fund’s fees and expenses) of an equity index called the Nasdaq US Smart Transportation Index (the “Index”). The shares of the Fund are listed and trade on The Nasdaq Stock Market LLC under the ticker symbol “FTXR.” The Fund will normally invest at least 90% of its net assets (including investment borrowings) in the common stocks and depositary receipts that comprise the Index. The Index is owned and is developed, maintained and sponsored by Nasdaq, Inc. (the “Index Provider”).

The Index is designed to provide exposure to U.S. companies comprising the transportation sector that have been selected based upon their liquidity and weighted based upon their cumulative score on three investing factors: volatility, value and growth. The Index’s initial selection universe consists of the component securities of the NASDAQ US Benchmark Index that have been classified as comprising the industrial transportation sector, the automobiles & parts sector or the airlines sub-sector according to the Industry Classification Benchmark. The NASDAQ US Benchmark Index is an index seeking to track the performance of small, mid and large capitalization U.S. companies. These classifications include: (i) operators of mail and package delivery services; (ii) providers of on-water transportation for commercial markets; (iii) providers of industrial railway transportation and railway lines; (iv) companies that manage airports, train depots, roads, bridges, tunnels, ports, and providers of logistic services to shippers of goods; (v) companies that provide commercial trucking services; (vi) makers of motorcycles and passenger vehicles; (vii) manufacturers and distributors of new and replacement parts for motorcycles and automobiles; (viii) manufacturers, distributors and retreaders of automobile, truck and motorcycle tires; and (ix) companies providing primarily passenger air transport.

The Fund generated a NAV return of -34.35% during the period covered by this report. During the same period, the NASDAQ US Benchmark Index (“Benchmark”) generated a return of -8.86%. The Fund allocated 68.0% to the Transportation industry within the Industrials sector, and 23.1% allocation went to Automobiles & Components in the Consumer Discretionary sector. The most positively contributing investments in an industry, and the only positively contributing industry, were investments in Capital Goods, which received 0.9% allocation and contributed 0.01% to the Fund’s total return. The most negatively contributing industry was the industry with the greatest weight, Transportation, which caused -20.6% total contribution to the Fund’s total return. On a relative basis, the Fund underperformed the Benchmark. The greatest contribution to underperformance came from investments in Transportation, which caused -14.2% of underperformance for the Fund versus the Benchmark. Some outperformance was earned for the Fund by allocating nothing to the Energy sector. This difference from the Benchmark earned 1.7% of outperformance for the Fund.

Nasdaq^® and Nasdaq US Smart Transportation Index (“the Nasdaq Indexes”) are registered trademarks and service marks of Nasdaq, Inc. (together with its affiliates hereinafter referred to as the “Corporations”) and are licensed for use by First Trust. The Fund has not been passed on by the Corporations as to its legality or suitability. The Fund is not issued, endorsed, sold or promoted by the Corporations. THE CORPORATIONS MAKE NO WARRANTIES AND BEAR NO LIABILITY WITH RESPECT TO THE FUND.

Page 17

First Trust Nasdaq Transportation ETF (FTXR) (Continued)

Sector Allocation	% of Total Investments
Industrials	67.8%
Consumer Discretionary	32.2
Total	100.0%

Top Ten Holdings	% of Total Investments
Kansas City Southern	10.8%
General Motors Co.	7.5
Old Dominion Freight Line, Inc.	6.7
Delta Air Lines, Inc.	6.5
JetBlue Airways Corp.	6.0
Tesla, Inc.	4.5
United Airlines Holdings, Inc.	4.4
Genuine Parts Co.	4.2
Southwest Airlines Co.	4.0
XPO Logistics, Inc.	3.8
Total	58.4%

Page 18

Total returns for the period since inception are calculated from the inception date of each Fund. “Average Annual Total Returns” represent the average annual change in value of an investment over the periods indicated. “Cumulative Total Returns” represent the total change in value of an investment over the periods indicated.

Each Fund’s per share net asset value (“NAV”) is the value of one share of the Fund and is computed by dividing the value of all assets of the Fund (including accrued interest and dividends), less all liabilities (including accrued expenses and dividends declared but unpaid), by the total number of outstanding shares. The price used to calculate market return (“Market Price”) is determined by using the midpoint between the highest bid and the lowest offer on the stock exchange on which shares of the Fund are listed for trading as of the time that the Fund’s NAV is calculated. Since shares of each Fund did not trade in the secondary market until after the Fund’s inception, for the period from inception to the first day of secondary market trading in shares of the Fund, the NAV of each Fund is used as a proxy for the secondary market trading price to calculate market returns. NAV and market returns assume that all distributions have been reinvested in each Fund at NAV and Market Price, respectively.

An index is a statistical composite that tracks a specified financial market or sector. Unlike each Fund, the indices do not actually hold a portfolio of securities and therefore do not incur the expenses incurred by each Fund. These expenses negatively impact the performance of each Fund. Also, market returns do not include brokerage commissions that may be payable on secondary market transactions. If brokerage commissions were included, market returns would be lower. The total returns presented reflect the reinvestment of dividends on securities in the indices. The returns presented do not reflect the deduction of taxes that a shareholder would pay on Fund distributions or the redemption or sale of Fund shares. The investment return and principal value of shares of each Fund will vary with changes in market conditions. Shares of each Fund may be worth more or less than their original cost when they are redeemed or sold in the market. Each Fund’s past performance is no guarantee of future performance.

Page 19

First Trust Exchange-Traded Fund VI

Understanding Your Fund Expenses

March 31, 2020 (Unaudited)

As a shareholder of First Trust Nasdaq Bank ETF, First Trust Nasdaq Food & Beverage ETF, First Trust Nasdaq Oil & Gas ETF, First Trust Nasdaq Pharmaceuticals ETF, First Trust Nasdaq Retail ETF, First Trust Nasdaq Semiconductor ETF or First Trust Nasdaq Transportation ETF (each a “Fund” and collectively, the “Funds”), you incur two types of costs: (1) transaction costs; and (2) ongoing costs, including management fees, distribution and/or service (12b-1) fees, if any, and other Fund expenses. This Example is intended to help you understand your ongoing costs of investing in the Funds and to compare these costs with the ongoing costs of investing in other funds.

The Example is based on an investment of $1,000 invested at the beginning of the period and held through the six-month period ended March 31, 2020.

Actual Expenses

The first line in the following table provides information about actual account values and actual expenses. You may use the information in this line, together with the amount you invested, to estimate the expenses that you paid over the period. Simply divide your account value by $1,000 (for example, an $8,600 account value divided by $1,000 = 8.6), then multiply the result by the number in the first line under the heading entitled “Expenses Paid During the Six-Month Period” to estimate the expenses you paid on your account during this six-month period.

Hypothetical Example for Comparison Purposes

The second line in the following table provides information about hypothetical account values and hypothetical expenses based on each Fund’s actual expense ratio and an assumed rate of return of 5% per year before expenses, which is not each Fund’s actual return. The hypothetical account values and expenses may not be used to estimate the actual ending account balance or expenses you paid for the period. You may use this information to compare the ongoing costs of investing in the Funds and other funds. To do so, compare this 5% hypothetical example with the 5% hypothetical examples that appear in the shareholder reports of the other funds.

Please note that the expenses shown in the table are meant to highlight your ongoing costs only and do not reflect any transactional costs such as brokerage commissions. Therefore, the second line in the table is useful in comparing ongoing costs only, and will not help you determine the relative total costs of owning different funds. In addition, if these transactional costs were included, your costs would have been higher.

Page 20

First Trust Exchange-Traded Fund VI

Understanding Your Fund Expenses (Continued)

March 31, 2020 (Unaudited)

	Beginning Account Value October 1, 2019	Ending Account Value March 31, 2020	Annualized Expense Ratio Based on the Six-Month Period	Expenses Paid During the Six-Month Period (a)
First Trust Nasdaq Semiconductor ETF (FTXL)
Actual	$1,000.00	$955.10	0.60%	$2.93
Hypothetical (5% return before expenses)	$1,000.00	$1,022.00	0.60%	$3.03
First Trust Nasdaq Transportation ETF (FTXR)
Actual	$1,000.00	$655.90	0.60%	$2.48
Hypothetical (5% return before expenses)	$1,000.00	$1,022.00	0.60%	$3.03

    

(a)	Expenses are equal to the annualized expense ratios as indicated in the table multiplied by the average account value over the period (October 1, 2019 through March 31, 2020), multiplied by 183/366 (to reflect the six-month period).

Page 21

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Page 29

First Trust Exchange-Traded Fund VI

Statements of Assets and Liabilities

March 31, 2020

	First Trust Nasdaq Bank ETF (FTXO)		First Trust Nasdaq Food & Beverage ETF (FTXG)		First Trust Nasdaq Oil & Gas ETF (FTXN)
ASSETS:
Investments, at value	$ 58,428,003		$ 2,589,749		$ 6,715,712
Cash	—		559		1,646
Receivables:
Dividends	284,494		3,349		1,132
Dividend reclaims	—		—		—
Investment securities sold	3,116,915		—		160,917
Miscellaneous	—		—		7,965
Total Assets	61,829,412		2,593,657		6,887,372
LIABILITIES:
Due to custodian	4,294		—		—
Payables:
Investment advisory fees	38,538		1,350		2,041
Fund shares redeemed	3,128,430		—		—
Total Liabilities	3,171,262		1,350		2,041
NET ASSETS	$58,658,150		$2,592,307		$6,885,331
NET ASSETS consist of:
Paid-in capital	$ 154,983,362		$ 3,611,101		$ 15,762,341
Par value	37,500		1,500		8,500
Accumulated distributable earnings (loss)	(96,362,712)		(1,020,294)		(8,885,510)
NET ASSETS	$58,658,150		$2,592,307		$6,885,331
NET ASSET VALUE, per share	$15.64		$17.28		$8.10
Number of shares outstanding (unlimited number of shares authorized, par value $0.01 per share)	3,750,002		150,002		850,002
Investments, at cost	$102,051,953		$3,307,756		$8,846,307

Page 30

See Notes to Financial Statements

First Trust Nasdaq Pharmaceuticals ETF (FTXH)		First Trust Nasdaq Retail ETF (FTXD)		First Trust Nasdaq Semiconductor ETF (FTXL)		First Trust Nasdaq Transportation ETF (FTXR)
$ 5,791,377		$ 3,609,497		$ 31,322,575		$ 1,503,284
620		6,328		38,447		7,855
4,175		5,462		10,657		712
287		—		—		79
16,028		—		—		—
—		—		—		—
5,812,487		3,621,287		31,371,679		1,511,930
—		—		—		—
2,959		2,004		18,828		572
—		—		—		—
2,959		2,004		18,828		572
$ 5,809,528		$ 3,619,283		$ 31,352,851		$ 1,511,358
$ 7,565,035		$ 5,915,845		$ 39,525,190		$ 2,437,051
3,000		2,000		9,500		1,000
(1,758,507)		(2,298,562)		(8,181,839)		(926,693)
$ 5,809,528		$ 3,619,283		$ 31,352,851		$ 1,511,358
$19.36		$18.10		$33.00		$15.11
300,002		200,002		950,002		100,002
$6,757,943		$4,713,438		$35,609,198		$1,898,119

See Notes to Financial Statements

Page 31

First Trust Exchange-Traded Fund VI

Statements of Operations

For the Year Ended March 31, 2020

		First Trust Nasdaq Bank ETF (FTXO)		First Trust Nasdaq Food & Beverage ETF (FTXG)		First Trust Nasdaq Oil & Gas ETF (FTXN)
INVESTMENT INCOME:
Dividends		$ 4,481,850		$ 72,082		$ 220,557
Interest		3,099		95		352
Total investment income		4,484,949		72,177		220,909
EXPENSES:
Investment advisory fees		818,681		19,879		48,457
Total expenses		818,681		19,879		48,457
NET INVESTMENT INCOME (LOSS)		3,666,268		52,298		172,452
NET REALIZED AND UNREALIZED GAIN (LOSS):
Net realized gain (loss) on:
Investments		(10,735,724)		(16,881)		(1,937,252)
In-kind redemptions		(3,502,413)		474,160		(835,293)
Net realized gain (loss)		(14,238,137)		457,279		(2,772,545)
Net change in unrealized appreciation (depreciation) on investments		(20,119,560)		(837,798)		(1,452,086)
NET REALIZED AND UNREALIZED GAIN (LOSS)		(34,357,697)		(380,519)		(4,224,631)
NET INCREASE (DECREASE) IN NET ASSETS RESULTING FROM OPERATIONS		$(30,691,429)		$(328,221)		$(4,052,179)

Page 32

See Notes to Financial Statements

	First Trust Nasdaq Pharmaceuticals ETF (FTXH)		First Trust Nasdaq Retail ETF (FTXD)		First Trust Nasdaq Semiconductor ETF (FTXL)		First Trust Nasdaq Transportation ETF (FTXR)
	$105,690		$125,421		$554,769		$45,414
	102		194		653		59
	105,792		125,615		555,422		45,473
	43,709		44,194		208,718		16,674
	43,709		44,194		208,718		16,674
	62,083		81,421		346,704		28,799
	(163,349)		(428,184)		(228,603)		(160,624)
	838,816		1,281,316		2,764,655		288,770
	675,467		853,132		2,536,052		128,146
	(1,041,156)		(1,325,454)		(4,808,273)		(382,690)
	(365,689)		(472,322)		(2,272,221)		(254,544)
	$(303,606)		$(390,901)		$(1,925,517)		$(225,745)

See Notes to Financial Statements

Page 33

First Trust Exchange-Traded Fund VI

Statements of Changes in Net Assets

	First Trust Nasdaq Bank ETF (FTXO)				First Trust Nasdaq Food & Beverage ETF (FTXG)
	Year Ended 3/31/2020		Year Ended 3/31/2019		Year Ended 3/31/2020		Year Ended 3/31/2019
OPERATIONS:
Net investment income (loss)	$ 3,666,268		$ 14,440,955		$ 52,298		$ 17,255
Net realized gain (loss)	(14,238,137)		11,148,105		457,279		(97,234)
Net change in unrealized appreciation (depreciation)	(20,119,560)		(123,008,249)		(837,798)		166,354
Net increase (decrease) in net assets resulting from operations	(30,691,429)		(97,419,189)		(328,221)		86,375
DISTRIBUTIONS TO SHAREHOLDERS FROM:
Investment operations	(3,868,010)		(14,689,357)		(51,985)		(14,971)
Return of capital	—		—		—		—
Total distributions to shareholders	(3,868,010)		(14,689,357)		(51,985)		(14,971)
SHAREHOLDER TRANSACTIONS:
Proceeds from shares sold	20,330,421		353,763,083		6,337,625		948,776
Cost of shares redeemed	(95,560,223)		(1,387,651,548)		(5,370,720)		—
Net increase (decrease) in net assets resulting from shareholder transactions	(75,229,802)		(1,033,888,465)		966,905		948,776
Total increase (decrease) in net assets	(109,789,241)		(1,145,997,011)		586,699		1,020,180
NET ASSETS:
Beginning of period	168,447,391		1,314,444,402		2,005,608		985,428
End of period	$58,658,150		$168,447,391		$2,592,307		$2,005,608
CHANGES IN SHARES OUTSTANDING:
Shares outstanding, beginning of period	6,900,002		44,550,002		100,002		50,002
Shares sold	800,000		12,000,000		300,000		50,000
Shares redeemed	(3,950,000)		(49,650,000)		(250,000)		—
Shares outstanding, end of period	3,750,002		6,900,002		150,002		100,002

Page 34

See Notes to Financial Statements

First Trust Nasdaq Oil & Gas ETF (FTXN)				First Trust Nasdaq Pharmaceuticals ETF (FTXH)				First Trust Nasdaq Retail ETF (FTXD)
Year Ended 3/31/2020		Year Ended 3/31/2019		Year Ended 3/31/2020		Year Ended 3/31/2019		Year Ended 3/31/2020		Year Ended 3/31/2019
$ 172,452		$ 337,433		$ 62,083		$ 27,637		$ 81,421		$ 62,033
(2,772,545)		(5,292,867)		675,467		(109,935)		853,132		(543,007)
(1,452,086)		(926,753)		(1,041,156)		146,896		(1,325,454)		225,610
(4,052,179)		(5,882,187)		(303,606)		64,598		(390,901)		(255,364)
(179,319)		(324,106)		(63,555)		(25,550)		(96,141)		(43,750)
(6,197)		—		—		—		—		—
(185,516)		(324,106)		(63,555)		(25,550)		(96,141)		(43,750)
12,391,122		40,494,178		4,298,507		7,921,843		2,487,585		14,840,691
(13,561,689)		(25,985,088)		(3,497,323)		(4,699,347)		(7,315,467)		(6,650,460)
(1,170,567)		14,509,090		801,184		3,222,496		(4,827,882)		8,190,231
(5,408,262)		8,302,797		434,023		3,261,544		(5,314,924)		7,891,117
12,293,593		3,990,796		5,375,505		2,113,961		8,934,207		1,043,090
$6,885,331		$12,293,593		$5,809,528		$5,375,505		$3,619,283		$8,934,207
650,002		200,002		250,002		100,002		400,002		50,002
1,300,000		1,700,000		200,000		350,000		100,000		650,000
(1,100,000)		(1,250,000)		(150,000)		(200,000)		(300,000)		(300,000)
850,002		650,002		300,002		250,002		200,002		400,002

See Notes to Financial Statements

Page 35

First Trust Exchange-Traded Fund VI

Statements of Changes in Net Assets (Continued)

	First Trust Nasdaq Semiconductor ETF (FTXL)				First Trust Nasdaq Transportation ETF (FTXR)
	Year Ended 3/31/2020		Year Ended 3/31/2019		Year Ended 3/31/2020		Year Ended 3/31/2019
OPERATIONS:
Net investment income (loss)	$ 346,704		$ 261,018		$ 28,799		$ 41,698
Net realized gain (loss)	2,536,052		(1,118,345)		128,146		(105,880)
Net change in unrealized appreciation (depreciation)	(4,808,273)		(1,466,467)		(382,690)		(4,821)
Net increase (decrease) in net assets resulting from operations	(1,925,517)		(2,323,794)		(225,745)		(69,003)
DISTRIBUTIONS TO SHAREHOLDERS FROM:
Investment operations	(356,856)		(228,505)		(28,821)		(40,176)
Return of capital	—		—		—		—
Total distributions to shareholders	(356,856)		(228,505)		(28,821)		(40,176)
SHAREHOLDER TRANSACTIONS:
Proceeds from shares sold	33,122,477		19,028,462		6,534,030		—
Cost of shares redeemed	(29,728,784)		(33,481,492)		(7,101,369)		(1,297,832)
Net increase (decrease) in net assets resulting from shareholder transactions	3,393,693		(14,453,030)		(567,339)		(1,297,832)
Total increase (decrease) in net assets	1,111,320		(17,005,329)		(821,905)		(1,407,011)
NET ASSETS:
Beginning of period	30,241,531		47,246,860		2,333,263		3,740,274
End of period	$31,352,851		$30,241,531		$1,511,358		$2,333,263
CHANGES IN SHARES OUTSTANDING:
Shares outstanding, beginning of period	950,002		1,450,002		100,002		150,002
Shares sold	900,000		600,000		300,000		—
Shares redeemed	(900,000)		(1,100,000)		(300,000)		(50,000)
Shares outstanding, end of period	950,002		950,002		100,002		100,002

Page 36

See Notes to Financial Statements