Exhibit (a)(1)(A)

OFFER TO EXCHANGE

SHARES OF COMMON STOCK FOR

CERTAIN OUTSTANDING WARRANTS

OF

ADHERA THERAPEUTICS, INC.

THE OFFER PERIOD AND YOUR RIGHT TO WITHDRAW WARRANTS THAT YOU TENDER WILL EXPIRE AT 5:30 P.M., EASTERN TIME, ON JUNE 25, 2019, UNLESS THE OFFER PERIOD IS EXTENDED.

Adhera Therapeutics, Inc., a Delaware corporation (the “ Company ”), is making an offer, upon the terms and conditions in this Offer to Exchange Letter (“ Offer Letter ”) and the related Letter of Transmittal (which together, as they may be amended or supplemented from time to time, constitute the “ Offer ”), to all holders of the Company’s issued and outstanding warrants that were issued to investors in connection with the private placements by the Company of shares of its Series E Convertible Preferred Stock, par value $0.01 per share (“ Series E Stock ”), and Series F Convertible Preferred Stock, par value $0.01 per share (“ Series F Stock ”), that were conducted during 2018 (such private placements, the “ Private Placements ”), which warrants are exercisable for shares of the Company’s common stock, par value $0.006 per share (the “ Shares ”), at an exercise price of $0.50 per Share (subject to adjustment) with respect to the warrants that were issued in connection with the Company’s private placement of Series E Stock (such warrants, the “ Series E Warrants ”) and at an exercise price of $0.55 per Share (subject to adjustment) with respect to the warrants that were issued in connection with the Company’s private placement of Series F Stock (such warrants, the “ Series F Warrants ”, and together with the Series E Warrants, the “ Warrants ”), to exchange during the Offer Period (as defined herein) two (2) Shares for each Warrant tendered. The “ Offer Period ” is the period commencing on May 28, 2019 and ending at 5:30 p.m., Eastern Time, on June 25, 2019, or such later date to which the Company may extend the Offer (the “ Expiration Date ”).

Concurrently with the Offer, the Company is also offering to each investor who purchased shares of Series E Stock and/or Series F Stock in the Private Placements a convertible promissory note to be issued by the Company in a principal amount that is not less than fifty percent (50%) of the purchase price of the Series E Stock and/or Series F Stock that each such investor purchased in the applicable Private Placement (such notes, the “ New Notes ”), together with a warrant to purchase such number Shares as is equal to twenty-five percent (25%) of the quotient obtained by dividing the principal amount of the applicable New Note by $0.175 (such warrants, the “ New Warrants ”; and the transaction pursuant to which the Company would issue the New Notes and the New Warrants, the “ Financing Transaction ”). As part of the Financing Transaction, it is contemplated that the holders of a majority of the outstanding shares of the Series E Stock and the Series F Stock will agree to convert all of the outstanding shares of Series E Stock and Series F Stock into Shares at a conversion price of $0.175, as a result of which conversion the Company will issue approximately 118.5 million Shares (before giving effect to any accrued dividends on the Series E Stock and Series F Stock following March 31, 2019). The Financing Transaction will be conducted pursuant to Section 4(a)(2) under the Securities Act and/or Rule 506(b) of Regulation D promulgated thereunder. A holder’s eligibility to participate in the Offer is conditioned upon such holder’s participation in the Financing Transaction.

Our Shares are listed on the OTCQB Tier of the OTC Markets under the symbol ATRX. On May 24, 2019, the last reported sale price for the Shares was $0.25. The Warrants are not listed or traded on any exchange or trading platform. Warrant holders should obtain current market quotations for the Shares before deciding whether to tender their Warrants pursuant to the Offer.

The Offer relates to the Warrants issued to investors in connection with the Private Placements. The Offer does not relate to any other warrants that have been issued by the Company. Any and all outstanding Warrants issued to investors in connection with the Private Placements are eligible to be tendered pursuant to the Offer, subject to the terms and conditions of the Offer. As of May 24, 2019, there were 26,177,078 Series E Warrants and 2,857,500 Series F Warrants outstanding.

The purpose of the Offer is to assist in the recapitalization of the Company in connection with the Financing Transaction, including the conversion of all outstanding shares of Series E Stock and Series F Stock into Shares in connection therewith.

The Offer is to permit the holders of the Warrants that were issued to investors in connection with the Private Placements to tender all outstanding Warrants at an exchange ratio of two (2) Shares for each Warrant tendered. A holder may only tender all, but not less than all, of such holder’s Warrants. A holder will not be able to tender only a portion of the Warrants that he, she or it holds. No fractional Shares will be issued. Warrants may only be exchanged for whole Shares. In lieu of issuing fractional Shares to which any holder of Warrants would otherwise have been entitled, the Company will round the number of Shares to which such holder is entitled, after aggregating all fractions, up to the next whole number of Shares. Holders are also entitled to exercise their Warrants during the Offer Period in accordance with the terms of the Warrants.

The Offer is subject to certain conditions, which we may waive or amend in our discretion. Among other things, the Offer is conditioned on the closing of the Financing Transaction (and the related conversion of all outstanding shares of Series E Stock and Series F Stock into Shares) and at least fifty percent (50%) of all outstanding Series E Warrants and fifty percent (50%) of all outstanding Series F Warrants being tendered. The Offer is also conditioned on the effectiveness of a one-for-two reverse split of the Shares to be effected by the Company, as a result of which the Company shall issue to each holder of Shares one (1) Share for every two (2) Shares then held by such holder (the “ Reverse Split ”). All Share and per Share information included in this Offer Letter shall be appropriately adjusted to give effect to the Reverse Split, but as presented in this Offer Letter do not give effect to the Reverse Split. Only those Warrant holders who participate in the Financing Transaction, and who purchase New Notes in an aggregate principal amount that is not less than fifty percent (50%) of the purchase price of the Series E Stock and/or Series F Stock that such Warrant holders purchased in the Private Placements, will have the right to exchange their Warrants for Shares in the Offer.

You may tender all, but not less than all, of your Warrants on the terms set forth in this Offer Letter and the related documents.

If you elect to tender Warrants in response to the Offer, please follow the instructions in this Offer Letter and the related documents, including the Letter of Transmittal. If you wish to exercise your Warrants in accordance with their terms, please follow the instructions for exercise included in the Warrants.

If you tender Warrants, you may withdraw your tendered Warrants before the Expiration Date and retain them on their terms by following the instructions herein. It is anticipated that the exercise price of any Warrants that you retain will be reduced to $0.175 as a result of the closing of the Financing Transaction.

Investing in the securities of the Company, including the Shares, involves a high degree of risk. See “The Offer, Section 12. Forward-Looking Statements; Risk Factors” for a discussion of information that you should consider before tendering Warrants in the Offer.

The Offer will commence on May 28, 2019 and end on the Expiration Date.

A detailed discussion of the Offer is contained in this Offer Letter. We may amend or terminate the Offer at any time with requisite notice, as further described in this Offer Letter. Holders of Warrants are strongly encouraged to read this entire package of materials, and the publicly-filed information about the Company referenced herein, as well as any supplemental disclosure regarding the Offer before making a decision regarding the Offer.

THE COMPANY’S BOARD OF DIRECTORS HAS UNANIMOUSLY APPROVED THE OFFER. HOWEVER, NONE OF THE COMPANY, ITS DIRECTORS, OFFICERS OR EMPLOYEES, NOR AMERICAN STOCK TRANSFER & TRUST COMPANY, THE DEPOSITARY FOR THE OFFER (“ AST ” OR THE “ DEPOSITARY ”), MAKES ANY RECOMMENDATION AS TO WHETHER YOU SHOULD TENDER WARRANTS. EACH HOLDER OF A WARRANT MUST MAKE HIS, HER OR ITS OWN DECISION AS TO WHETHER TO TENDER HIS, HER OR ITS WARRANTS.

Neither the U.S. Securities and Exchange Commission (the “ SEC ”) nor any state securities commission has approved or disapproved of the Offer or passed upon the merits or fairness of the Offer or the accuracy or adequacy of the disclosure in this Offer Letter or the Letter of Transmittal. Any representation to the contrary is a criminal offense.

We are relying on Rule 506(b) of Regulation D promulgated under the Securities Act of 1933, as amended (the “ Securities Act ”), to exempt the Offer from the registration requirements of the Securities Act . We are also relying on the applicable provisions of Section 18(b)(4) of the Securities Act to exempt the Offer from the registration and qualification requirements of state securities laws. We have no contract, arrangement or understanding relating to the payment of, and will not, directly or indirectly, pay, any commission or other remuneration to any broker, dealer, salesperson, agent or any other person for soliciting tenders in the Offer. In addition, neither the Depositary nor any broker, dealer, salesperson, agent or any other person is engaged or authorized to express any statement, opinion, recommendation or judgment with respect to the relative merits and risks of the Offer. Our officers, directors and regular employees may solicit tenders from holders of the Warrants and will answer inquiries concerning the terms of the Offer, but they will not receive additional compensation for soliciting tenders or answering any such inquiries.

Questions and requests for assistance regarding the Offer and requests for additional copies of the Offer to Exchange and the Offer documents may be directed to the Company, at the telephone numbers and address set forth on the back cover of this Offer to Exchange.

May 28, 2019

IMPORTANT PROCEDURES

If you want to tender your Warrants, you must, before the Expiration Date, complete and sign the Letter of Transmittal according to its instructions, and deliver the Letter of Transmittal, together with any required signature guarantee, the certificates for your Warrants and any other documents required by the Letter of Transmittal, to AST.

If you want to tender your Warrants, but:

then you can still tender your Warrants if you comply with the procedures described under “The Offer, Section 2. Procedure for Tendering Warrants.”

TO TENDER YOUR WARRANTS, YOU MUST CAREFULLY FOLLOW THE PROCEDURES DESCRIBED IN THIS OFFER LETTER, THE LETTER OF TRANSMITTAL AND THE OTHER DOCUMENTS DISCUSSED HEREIN RELATED TO THE OFFER.

NO FRACTIONAL SHARES WILL BE ISSUED. WARRANTS MAY ONLY BE EXCHANGED FOR WHOLE SHARES. IN LIEU OF ISSUING FRACTIONAL SHARES TO WHICH ANY HOLDER OF WARRANTS WOULD OTHERWISE HAVE BEEN ENTITLED, THE COMPANY WILL ROUND THE NUMBER OF SHARES TO WHICH SUCH HOLDER IS ENTITLED, AFTER AGGREGATING ALL FRACTIONS, UP TO THE NEXT WHOLE NUMBER OF SHARES. SHARES WILL BE ISSUED TO YOU IN BOOK ENTRY FORMAT.

WARRANTS NOT EXCHANGED FOR SHARES WILL EXPIRE IN ACCORDANCE WITH THEIR TERMS AND OTHERWISE WILL REMAIN SUBJECT TO THEIR ORIGINAL TERMS.

THE OFFER RELATES TO THE WARRANTS ISSUED TO INVESTORS IN CONNECTION WITH THE PRIVATE PLACEMENTS. THE OFFER DOES NOT RELATE TO ANY OTHER WARRANTS THAT WERE ISSUED BY THE COMPANY. ANY AND ALL OUTSTANDING WARRANTS ISSUED TO INVESTORS IN CONNECTION WITH THE PRIVATE PLACEMENTS ARE ELIGIBLE TO BE TENDERED PURSUANT TO THE OFFER. AS OF MAY 24, 2019, THERE WERE 26,177,078 SERIES E WARRANTS AND 2,857,500 SERIES F WARRANTS OUTSTANDING.

TABLE OF CONTENTS

We are not making the Offer to, and will not accept any tendered Warrants from, Warrant holders in any jurisdiction where it would be illegal to do so. However, we may, at our discretion, take any actions necessary for us to make the Offer to Warrant holders in any such jurisdiction.

You should rely only on the information contained in this Offer Letter and in the Letter of Transmittal or to which we have referred you. We have not authorized anyone to provide you with information or to make any representation in connection with the Offer other than those contained in this Offer Letter or in the Letter of Transmittal. If anyone makes any recommendation or gives any information or representation regarding the Offer, you should not rely upon that recommendation, information or representation as having been authorized by us, our board of directors, or the Depositary. You should not assume that the information provided in the Offer is accurate as of any date other than the date as of which it is shown, or if no date is otherwise indicated, the date of this Offer Letter.

SUMMARY

Unless otherwise stated in this Offer Letter, references to “we,” “our,” “us,” or the “Company” refer to Adhera Therapeutics, Inc. An investment in our securities involves risks. You should carefully consider the information provided under the heading “Forward-Looking Statements; Risk Factors” beginning on page 13.

THE OFFER

Risks of Participating In the Offer

Participation in the Offer involves a number of risks, including, but not limited to, the risks identified in Section 12 below. Holders of Warrants should carefully consider these risks and are urged to speak with their personal financial, investment and/or tax advisors as necessary before deciding whether to participate in the Offer. In addition, we strongly encourage you to read this Offer Letter in its entirety and review the documents referred to in Sections 8, 9, 12 and 15.

The Offer is to permit holders of Warrants issued by the Company to investors in connection with the Private Placements to tender any and all outstanding Warrants at an exchange ratio of two (2) Shares for each Warrant tendered. A holder may tender all, but not less than all, of the Warrants held by such holder. No fractional Shares will be issued. Warrants may only be exchanged for whole Shares. In lieu of issuing fractional Shares to which any holder of Warrants would otherwise have been entitled, the Company will round the number of Shares to which such holder is entitled, after aggregating all fractions, up to the next whole number of Shares. Holders may also exercise their Warrants during the Offer Period in accordance with the terms of the Warrant.

You may tender all, but not less than all, of your Warrants on these terms. The Offer relates to the Warrants that were issued by the Company to investors in connection with the Private Placements, which Warrants are neither listed nor traded on any exchange or trading platform. The Offer does not relate to any other warrants that have been issued by the Company. Any and all outstanding Warrants are eligible to be tendered pursuant to the Offer. As of May 24, 2019, there were 26,177,078 Series E Warrants and 2,857,500 Series F Warrants outstanding.

If you elect to tender Warrants in response to the Offer, please follow the instructions in this Offer Letter and the related documents, including the Letter of Transmittal.

Concurrently with the Offer, the Company is also offering to each investor who purchased shares of Series E Stock and/or Series F Stock in the Private Placements the opportunity to purchase a New Note in a principal amount that is not less than fifty percent (50%) of the purchase price of the securities that each such investor purchased in the applicable Private Placement, together with a New Warrant to purchase such number Shares as is equal to twenty-five percent (25%) of the quotient obtained by dividing the principal amount of the applicable New Note by $0.175, in the Financing Transaction. As part of the Financing Transaction, the holders of a majority of the outstanding shares of the Series E Stock and the Series F Stock will agree to convert all of the outstanding shares of Series E Stock and Series F Stock into Shares at a conversion price of $0.175, as a result of which conversion the Company will issue approximately 118.5 million Shares (before giving effect to any accrued dividends on the Series E Stock and Series F Stock following March 31, 2019). The Financing Transaction will be conducted pursuant to Section 4(a)(2) under the Securities Act and/or Rule 506(b) of Regulation D promulgated thereunder.

If you tender Warrants, you may withdraw your tendered Warrants before the Expiration Date and retain them on their terms by following the instructions herein. It is anticipated that the exercise price of any Warrants that you retain will be reduced to $0.175 as a result of the closing of the Financing Transaction.

The Shares to be exchanged for the Warrants have not been registered with the SEC. As described elsewhere in this Offer Letter, the issuance of the Shares upon exchange of the Warrants is exempt from the registration requirements of the Securities Act pursuant to Rule 506(b) of Regulation D promulgated thereunder. Under current interpretations of the staff of the Division of Corporation Finance of the SEC, securities that are issued pursuant to Rule 506 promulgated under the Securities Act are deemed to be restricted securities. We are also relying on the applicable provisions of Section 18(b)(4) of the Securities Act to exempt the Shares from the registration and qualification requirements of state securities laws. Neither the issuance nor the resale of the Shares that you receive in the Offer will be registered under the Securities Act, and thus will be subject to restriction under applicable law.

A. Period of Offer

The Offer will only be open for a period beginning on May 28, 2019 and ending on the Expiration Date. We expressly reserve the right, in our sole discretion, at any time or from time to time, prior to the Expiration Date, to extend the period of time during which the Offer is open. There can be no assurance, however, that we will exercise our right to extend the Offer.

B. Partial Tender Not Permitted

Only those Warrant holders who participate in the Financing Transaction, and who purchase New Notes in an aggregate principal amount that is not less than fifty percent (50%) of the purchase price of the Series E Stock and/or Series F Stock that such Warrant holders purchased in the Private Placements, will have the right to exchange their Warrants for Shares in the Offer. All other Warrant holders will not be eligible to participate in the Offer.

HOLDERS MAY ALSO EXERCISE THEIR WARRANTS DURING THE OFFER PERIOD IN ACCORDANCE WITH THE TERMS OF THE WARRANTS.

C. Board Approval of the Offer; No Recommendation; Holder’s Own Decision

THE COMPANY’S BOARD OF DIRECTORS HAS UNANIMOUSLY APPROVED THE OFFER. HOWEVER, NONE OF THE COMPANY, ITS DIRECTORS, OFFICERS OR EMPLOYEES, NOR THE DEPOSITARY, MAKES ANY RECOMMENDATION AS TO WHETHER TO TENDER WARRANTS. EACH HOLDER OF A WARRANT MUST MAKE HIS, HER OR ITS OWN DECISION AS TO WHETHER TO TENDER SOME OR ALL OF HIS, HER OR ITS WARRANTS.

D. Extensions of the Offer

We expressly reserve the right, in our sole discretion, and at any time or from time to time, prior to the Expiration Date, to extend the period of time during which the Offer is open. There can be no assurance, however, that we will exercise our right to extend the Offer. If we extend the Offer, we will give notice of such extension by press release or other public announcement no later than 9:00 a.m., Eastern Time, on the next business day after the previously scheduled Expiration Date of the Offer.

A. Proper Tender of Warrants

To validly tender Warrants pursuant to the Offer, a properly completed and duly executed Letter of Transmittal or photocopy thereof, together with any required signature guarantees, must be received by the Depositary at its address set forth on the last page of this document prior to the Expiration Date. The method of delivery of all required documents is at the option and risk of the tendering Warrant holders. If delivery is by mail, the Company recommends registered mail with return receipt requested (properly insured). In all cases, sufficient time should be allowed to assure timely delivery.

In the Letter of Transmittal, the tendering Warrant holder must: (i) set forth his, her or its name and address; (ii) set forth the number of Warrants tendered; and (iii) set forth the number of the Warrant certificate(s) representing such Warrants.

Where Warrants are tendered by a registered holder of the Warrants who has completed either the box entitled “Special Issuance Instructions” or the box entitled “Special Delivery Instructions” on the Letter of Transmittal, all signatures on the Letters of Transmittal must be guaranteed by an “Eligible Institution.”

An “Eligible Institution” is a bank, broker, dealer, credit union, savings association or other entity that is a member in good standing of the Securities Transfer Agents Medallion Program or a bank, broker, dealer, credit union, savings association or other entity which is an “eligible guarantor institution,” as that term is defined in Rule 17Ad-15 promulgated under the Securities Exchange Act of 1934, as amended (the “ Exchange Act ”).

If the Warrants are registered in the name of a person other than the signer of the Letter of Transmittal, the Warrants must be endorsed or accompanied by appropriate instruments of assignment, in either case signed exactly as the name(s) of the registered owner(s) appear on the Warrants, with the signature(s) on the Warrants or instruments of assignment guaranteed.

A tender of Warrants pursuant to the procedures described below in this Section 2 will constitute a binding agreement between the tendering holder and the Company upon the terms and subject to the conditions of the Offer.

ALL DELIVERIES IN CONNECTION WITH THE OFFER, INCLUDING A LETTER OF TRANSMITTAL AND WARRANTS, MUST BE MADE TO THE DEPOSITARY.

NO DELIVERIES SHOULD BE MADE TO THE COMPANY, AND ANY DOCUMENTS DELIVERED TO THE COMPANY WILL NOT BE FORWARDED TO THE DEPOSITARY AND THEREFORE WILL NOT BE DEEMED TO BE PROPERLY TENDERED. IN ALL CASES, SUFFICIENT TIME SHOULD BE ALLOWED TO ENSURE TIMELY DELIVERY.

B. Determination of Validity

All questions as to the form of documents and the validity, eligibility (including time of receipt) and acceptance for exchange of any tenders of Warrants will be determined by the Company, in its sole discretion, and its determination will be final and binding, subject to the judgment of any court that might provide otherwise. The Company reserves the absolute right, subject to the judgment of any court that might provide otherwise, to reject any or all tenders of Warrants that it determines are not in proper form or reject tenders of Warrants that may, in the opinion of the Company’s counsel, be unlawful. The Company also reserves the absolute right, subject to the judgment of any court that might provide otherwise, to waive any defect or irregularity in any tender of Warrants. Neither the Company nor any other person will be under any duty to give notice of any defect or irregularity in tenders, nor will any of them incur any liability for failure to give any such notice.

C. Tender Constitutes an Agreement

A tender of Warrants made pursuant to any method of delivery set forth herein will also constitute an acknowledgement by the tendering Warrant holder that: (i) the Offer is discretionary and may be extended, modified, suspended or terminated by us as provided herein; (ii) such Warrant holder is voluntarily participating in the Offer, subject to the terms and conditions of the Offer; (iii) the future value of our Warrants is unknown and cannot be predicted with certainty; (iv) such Warrant holder has read this Offer Letter; (v) such Warrant holder has consulted his, her or its tax and financial advisors with regard to how the Offer will impact the tendering Warrant holder’s specific situation; (vi) any foreign exchange obligations triggered by such Warrant holder’s tender of Warrants or receipt of proceeds are solely his, her or its responsibility; and (vii) regardless of any action that we take with respect to any or all income/capital gains tax, social security or insurance tax, transfer tax or other tax-related items (“ Tax Items ”) related to the Offer and the disposition of Warrants, such Warrant holder acknowledges that the ultimate liability for all Tax Items is and remains his, her or its sole responsibility. In that regard, a tender of Warrants authorizes us to withhold all applicable Tax Items potentially payable by a tendering Warrant holder. Our acceptance for payment of Warrants tendered pursuant to the Offer will constitute a binding agreement between the tendering Warrant holder and us upon the terms and subject to certain conditions of the Offer.

D. Signature Guarantees

Except as otherwise provided below, all signatures on a Letter of Transmittal by a person residing in or tendering Warrants in the United States must be guaranteed by an Eligible Institution. Signatures on a Letter of Transmittal need not be guaranteed if (i) the Letter of Transmittal is signed by the registered holder of the Warrant(s) tendered therewith and such holder has not completed the box entitled “Special Delivery Instructions” or “Special Issuance Instructions” in the Letter of Transmittal; or (ii) such Warrant(s) are tendered for the account of an Eligible Institution. See Instructions 1 and 5 of the Letter of Transmittal.

Tenders of Warrants made pursuant to the Offer may be rescinded at any time prior to the Expiration Date. Thereafter, such tenders are irrevocable. If the Company extends the period of time during which the Offer is open for any reason, then, without prejudice to the Company’s rights under the Offer and in a manner compliant with Rule 14e-1(c) of the Exchange Act, the Company may retain all Warrants tendered and tenders of such Warrants may not be rescinded, except as otherwise provided in this Section 3. Notwithstanding the foregoing, tendered Warrants may also be withdrawn if the Company has not accepted the Warrants for exchange by the 40 ^th business day after the initial commencement of the Offer.

To be effective, a written notice of withdrawal must be timely received by the Depositary at its address identified in this Offer Letter. Any notice of withdrawal must specify the name of the holder who tendered the Warrants for which tenders are to be withdrawn and the number of Warrants to be withdrawn. If the Warrants to be withdrawn have been delivered to the Depositary, a signed notice of withdrawal must be submitted to the Depositary prior to release of such Warrants. In addition, such notice must specify the name of the registered holder (if different from that of the tendering Warrant holder) and the serial numbers shown on the particular certificates evidencing the Warrants to be withdrawn, if any. Withdrawal may not be cancelled, and Warrants for which tenders are withdrawn will thereafter be deemed not validly tendered for purposes of the Offer. However, Warrants for which tenders are withdrawn may be tendered again by following one of the procedures described in Section 2 at any time prior to the Expiration Date.

A holder who tendered his, her or its Warrants should send written notice of withdrawal to the Depositary specifying the name of the Warrant holder who tendered the Warrants being withdrawn. All signatures on a notice of withdrawal must be guaranteed by a Medallion Signature Guarantor; provided, however, that signatures on the notice of withdrawal need not be guaranteed if the Warrants being withdrawn are held for the account of an Eligible Institution. Withdrawal of a prior Warrant tender will be effective upon receipt of the notice of withdrawal by the Depositary. Selection of the method of notification is at the risk of the Warrant holder, and notice of withdrawal must be timely received by the Depositary.

All questions as to the form and validity (including time of receipt) of any notice of withdrawal will be determined by the Company, in its sole discretion, which determination will be final and binding, subject to the judgment of any court that might provide otherwise. Neither the Company nor any other person will be under any duty to give notification of any defect or irregularity in any notice of withdrawal or incur any liability for failure to give any such notification, subject to the judgment of any court that might provide otherwise.

Upon the terms and subject to the conditions of the Offer, we will accept for exchange Warrants validly tendered as of the Expiration Date. The Shares to be issued will be delivered promptly following the Expiration Date, subject to any restrictions relating to such Shares. In all cases, Warrants will only be accepted for exchange pursuant to the Offer after timely receipt by the Depositary of a properly completed and duly executed Letter of Transmittal (or copy thereof), and any other documents required by the Letter of Transmittal. The Shares will be issued to you in book entry format.

For purposes of the Offer, the Company will be deemed to have accepted for exchange Warrants that are validly tendered and for which tenders are not withdrawn, unless the Company gives written notice to the Warrant holder of its non-acceptance prior to the Expiration Date.

We are relying on Rule 506(b) of Regulation D promulgated under the Securities Act to exempt the Offer from the registration requirements of the Securities Act. We are also relying on the applicable provisions of Section 18(b)(4) of the Securities Act to exempt the Offer from the registration and qualification requirements of state securities laws. We have no contract, arrangement or understanding relating to the payment of, and will not, directly or indirectly, pay, any commission or other remuneration to any broker, dealer, salesperson, agent or any other person for soliciting tenders in the Offer. In addition, none of the Depositary or any broker, dealer, salesperson, agent or any other person is engaged or authorized to express any statement, opinion, recommendation or judgment with respect to the relative merits and risks of the Offer. Our officers and directors may solicit tenders from holders of the Warrants and will answer inquiries concerning the terms of the Offer, but they will not receive additional compensation for soliciting tenders or answering any such inquiries.

A. Information Concerning Adhera Therapeutics, Inc.

Adhera Therapeutics, Inc. is an emerging specialty pharmaceutical company that leverages innovative distribution models and technologies to improve the quality of care for patients in the United States suffering from chronic and acute diseases. The Company is focused on fixed dose combination (“FDC”) therapies in hypertension, with plans to expand the portfolio of drugs that it commercializes to include other therapeutic areas.

The Company’s mission is to provide effective and patient centric treatment for hypertension and resistant hypertension while actively seeking additional assets that can be commercialized through its proprietary Total Care System. At the core of the Company’s Total Care System is DyrctAxess, the Company’s patented technology platform. DyrctAxess is designed to offer enhanced efficiency, control and access to the information necessary to empower patients, physicians and manufacturers to achieve optimal care.

The Company began marketing Prestalia®, a single-pill FDC of perindopril arginine (“perindopril”) and amlodipine besylate (“amlodipine”) in June of 2018. By combining Prestalia, DyrctAxess and an independent pharmacy network, the Company has created a proprietary system for drug adherence and the effective treatment of hypertension, improving the distribution of FDC hypertensive drugs, such as its U.S. Food and Drug Administration (“FDA”) approved product Prestalia, as well as improving the distribution of devices for therapeutic drug monitoring (“TDM”) (e.g., blood pressure monitors), as well as patient counseling and prescription reminder services. The Company is focused on demonstrating the therapeutic and commercial value of its Total Care System through the commercialization of Prestalia. Prestalia was developed in coordination with Servier, a French pharmaceutical conglomerate, that sells the formulation outside the United States under the brand names Coveram® and/or Viacoram®. Prestalia was approved by the FDA in January 2015 and is distributed through the DyrctAxess platform.

Our principal executive offices are located at 4721 Emperor Boulevard, Suite 350, Durham, North Carolina 27703, and our telephone number is (919) 578-5901.

For more information about Adhera Therapeutics, see our Annual Report on Form 10-K for the fiscal year ended December 31, 2018, which we filed with the SEC on April 16, 2019, and our Quarterly Report on Form 10-Q for the fiscal quarter ended March 31, 2019, which we filed with the SEC on May 15, 2019.

B. Establishment of Offer Terms; Approval of the Offer

Our board of directors approved this Offer and the exchange ratio and other terms of this Offer. Our board of directors set the exchange ratio, and the other terms and conditions of this Offer, in order to provide the holders of the Warrants with an incentive to exchange the Warrants.

C. Purpose of the Offer

The Offer is being made to all holders of Warrants that we issued to investors in connection with the Private Placements, and it is being made in conjunction with (and is conditioned upon the closing of) the Financing Transaction. The Company’s board of directors believes that the Financing Transaction will provide the Company with sufficient proceeds to continue its anticipated business operations until the fourth quarter of 2019, and that the Offer and the Financing Transaction (including the conversion of the Series E Stock and Series F Stock to be effected in connection therewith and the Reverse Split) will result in a significant simplification of the capital structure of the Company in anticipation of the Company’s future financing initiatives and a potential application to list the Shares on the NASDAQ Capital Market. Only those Warrant holders who participate in the Financing Transaction and who purchase New Notes in an aggregate principal amount that is not less than fifty percent (50%) of the purchase price of the Series E Stock and/or Series F Stock that such Warrant holders purchased in the Private Placements will be eligible to tender their Warrants in the Offer. The Warrants acquired pursuant to the Offer will be retired and cancelled. The Offer is not made pursuant to a plan to periodically increase any securityholder’s proportionate interest in the assets or earnings and profits of the Company.

D. Interests of Directors and Executive Officers

The names of the executive officers and directors of the Company are set forth below. The business address for each such person is: c/o Adhera Therapeutics, Inc., 4721 Emperor Boulevard, Suite 350, Durham, North Carolina 27703, and the telephone number for each such person is (919) 578-5901.

During the last five years, none of our directors or executive officers has been (a) convicted in a criminal proceeding (excluding traffic violations or similar misdemeanors) or (b) a party to any judicial or administrative proceeding (except for matters that were dismissed without sanction or settlement) that resulted in a judgment or decree or final order enjoining the person from future violations of, or prohibiting activities subject to, federal or state securities laws, or a finding of any violation of federal or state securities laws.

As of March 31, 2019, the Company had 10,761,684 outstanding Shares, 100 outstanding shares of Series C Convertible Preferred Stock (convertible into 66,666 Shares at a current conversion price of $7.50), 40 outstanding shares of Series D Convertible Preferred Stock (convertible into 50,000 Shares at a current conversion price of $4.00), 3,488 outstanding shares of Series E Convertible Preferred Stock (convertible into 34,880,000 Shares at a current conversion price of $0.50 (which conversion price would be reduced to $0.175 as a result of the Financing Transaction)), 381 outstanding shares of Series F Convertible Preferred Stock (convertible into 3,810,000 Shares at a current conversion price of $0.50 (which conversion price would be reduced to $0.175 as a result of the Financing Transaction)), 26,177,078 outstanding Series E Warrants, 2,857,500 Series F Warrants, 7,232,751 outstanding warrants (other than the Warrants), and options to purchase up to 5,748,057 Shares. The Shares issuable upon exchange of the outstanding Warrants pursuant to the Offer, after giving effect to the Offer, represent approximately 84% of our outstanding Shares as of May 24, 2019, and it is anticipated that the Shares issuable upon exchange of the outstanding Warrants pursuant to the Offer will represent approximately 20 % of our outstanding Shares on a fully diluted basis (assuming the conversion or exercise of any securities that are convertible into or exercisable for Shares) after giving effect to the Offer and the Financing Transaction (including the conversion of all outstanding shares of Series E Stock and Series F Stock at a conversion price of $0.175 to be effected in connection therewith).

To our knowledge, none of our directors or executive officers beneficially own Warrants, other than Isaac Blech, who owns (whether directly or through a trust affiliated with him) 790,725 Warrants, and Donald A. Williams, who owns 135,000 Warrants. As holders of Warrants, Messrs. Blech and Williams may participate in the Offer. In addition, all of the directors and executive officers of the Company, other than Mr. Boris, either own Shares or securities that are convertible into or exercisable for Shares. The Company does not beneficially own any Warrants.

We have not and, to the best of our knowledge, none of our current directors, executive officers or any person holding a controlling interest in us has, engaged in any transactions involving the Warrants during the 60-day period prior to the date of this Offer Letter. The Warrants were issued to investors in connection with the closings of the Private Placements in April, May, July and November of 2018. None of the Warrants have been exercised to date.

NONE OF THE COMPANY OR ANY OF ITS DIRECTORS, OFFICERS OR EMPLOYEES, OR THE DEPOSITARY, MAKES ANY RECOMMENDATION TO ANY HOLDER OF WARRANTS AS TO WHETHER TO EXERCISE SOME OR ALL OF THEIR WARRANTS. EACH HOLDER OF WARRANTS MUST MAKE HIS OR HER OWN DECISION AS TO WHETHER TO EXERCISE THEIR WARRANTS.

E. Plans, Proposals or Negotiations

Except as set forth below in Section 8 hereunder, there are no present plans, proposals or negotiations by the Company that relate to or would result in:

Notwithstanding the foregoing, we reserve the right to change our plans and intentions at any time, as we deem appropriate.

THE COMPANY’S BOARD OF DIRECTORS HAS UNANIMOUSLY APPROVED THE OFFER AND THE FINANCING TRANSACTION. HOWEVER, NONE OF THE COMPANY, ITS DIRECTORS, OFFICERS OR EMPLOYEES, NOR THE DEPOSITARY, MAKES ANY RECOMMENDATION AS TO WHETHER YOU SHOULD TENDER ANY WARRANTS. EACH HOLDER OF A WARRANT MUST MAKE HIS, HER OR ITS OWN DECISION AS TO WHETHER TO TENDER HIS, HER OR ITS WARRANTS.

6. PRICE RANGE OF SHARES

Our Shares are quoted on the OTCQB Tier of the OTC Markets under the symbol ATRX. On May 24, 2019, the last reported sale prices for the Shares was $0.25. The table below sets forth, for each of the quarterly periods indicated, the range of high and low bid prices of our Shares, as reported by the OTC Markets. The prices reflect inter-dealer prices, without retail mark-up, mark-down or commission, and may not represent actual transactions.

The Company recommends that holders of Warrants consider current market quotations for the Shares, among other factors, before deciding whether or not to tender their Warrants.

7. SOURCE AND AMOUNT OF FUNDS

Because this transaction is an offer to holders to exchange their existing Warrants for Shares, there is no source of funds or other cash consideration being paid by the Company to those tendering Warrants. We will use our existing funds to pay expenses associated with the Offer.

8. TRANSACTIONS AND AGREEMENTS CONCERNING THE COMPANY’S SECURITIES

Except as described herein, none of the Company or, to our knowledge, any of our affiliates, directors or executive officers, is a party to any contract, arrangement, understanding or agreement with any other person relating, directly or indirectly, to the Offer or with respect to any of our securities, including any contract, arrangement, understanding or agreement concerning the transfer or the voting of the securities, joint ventures, loan or option arrangements, puts or calls, guaranties of loans, guaranties against loss or the giving or withholding of proxies, consents or authorizations.

Series E Warrants

As of May 24, 2019, there were outstanding 26,177,078 Series E Warrants. Each Series E Warrant entitles the holder thereof to purchase one (1) Share. The Series E Warrants are immediately exercisable, have a cashless exercise provision, are subject to customary anti-dilution adjustments and are exercisable at a price of $0.50 per share; provided , that is contemplated that the exercise price of the Series E Warrants will be reduced to $0.175 as a result of the closing of the Financing Transaction. The Series E Warrants are exercisable until July 12, 2023. The Series E Warrants are subject to a provision prohibiting the exercise of such Series E Warrants to the extent that, after giving effect to such exercise, the holder of such Series E Warrant (together with the holder’s affiliates, and any other persons acting as a group together with the holder or any of the holder’s affiliates), would beneficially own in excess of 9.99% of the outstanding Shares. The Series E Warrants also provide for “full-ratchet” anti-dilution protection with respect to subsequent equity sales in which any person will be entitled to acquire Shares at an effective price per share that is lower than the then exercise price of the Series E Warrants, subject to customary exceptions..

Series F Warrants

As of May 24, 2019, there were outstanding 2,857,500 Series F Warrants. Each Series F Warrant entitles the holder thereof to purchase one (1) Share. The Series F Warrants are immediately exercisable, have a cashless exercise provision, are subject to customary anti-dilution adjustments and are exercisable at a price of $0.55 per share; provided , that is contemplated that the exercise price of the Series F Warrants will be reduced to $0.175 as a result of the closing of the Financing Transaction. The Series F Warrants are exercisable until November 9, 2023. The Series F Warrants are subject to a provision prohibiting the exercise of such Series F Warrants to the extent that, after giving effect to such exercise, the holder of such Series F Warrant (together with the holder’s affiliates, and any other persons acting as a group together with the holder or any of the holder’s affiliates), would beneficially own in excess of 9.99% of the outstanding Shares. The Series F Warrants also provide for “full-ratchet” anti-dilution protection with respect to subsequent equity sales in which any person will be entitled to acquire Shares at an effective price per share that is lower than the then exercise price of the Series F Warrants, subject to customary exceptions..

Other Agreements and Transactions

The Company has retained AST to act as the Depositary. Directors, officers and employees of either us or our affiliates may contact holders of Warrants by hand, mail, telephone or facsimile regarding the Offer and may request brokers, dealers and other nominees to forward the Offer Letter and related materials to beneficial owners of the Warrants. Such directors, officers and employees will not be specifically compensated for providing such services. AST will receive reasonable and customary compensation for its services in connection with the Offer, plus reimbursement for out-of-pocket expenses, and will be indemnified by the Company against certain liabilities and expenses in connection therewith.

We have no contract, arrangement or understanding relating to the payment of, and will not, directly or indirectly, pay any commission or other remuneration to any broker, dealer, salesperson, agent or any other person for soliciting tenders in the Offer.

9. FINANCIAL INFORMATION REGARDING THE COMPANY

The financial information included under Part II, Item 8 in our Annual Report on Form 10-K for the fiscal year ended December 31, 2018, and the financial information included under Part I, Item 1 in our Quarterly Report on Form 10-Q for the fiscal quarter ended March 31, 2019, is incorporated herein by reference. The full text of all such filings with the SEC, as well as other documents we have filed with the SEC prior to, or will file with the SEC subsequent to, the filing of the Tender Offer Statement on Schedule TO can be accessed electronically on the SEC’s website at www.sec.gov.

Book value per share

Our book value per Share as of March 31, 2019, determined in accordance with generally accepted accounting principles, was $0.0355.

10. CONDITIONS; TERMINATION; WAIVERS; EXTENSIONS; AMENDMENTS

The Offer is conditioned on the effectiveness of the Reverse Split, the closing of the Financing Transaction (and the related conversion of all outstanding shares of Series E Stock and Series F Stock into Shares) and at least fifty percent (50%) of all outstanding Series E Warrants and at least fifty percent (50%) of all outstanding Series F Warrants being tendered.

In addition, the Offer is conditioned on the following:

The foregoing conditions are solely for our benefit, and we may assert one or more of the conditions regardless of the circumstances giving rise to any such conditions. We may also, in our sole and absolute discretion, waive these conditions in whole or in part, subject to the potential requirement to disseminate additional information and extend the Offer, as described below. The determination by us as to whether any condition has been satisfied shall be conclusive and binding on all parties. The failure by us at any time to exercise any of the foregoing rights shall not be deemed a waiver of any such right and each such right shall be deemed a continuing right which may be asserted at any time and from time to time prior to the Expiration Date.

We may terminate the Offer if any of the conditions of the Offer are not satisfied prior to the Expiration Date. In the event that we terminate the Offer, all Warrants tendered by a Warrant holder in connection with the Offer will be returned to such Warrant holder and the Warrants will otherwise remain subject to their original terms.

Subject to applicable securities laws and the terms and conditions set forth in this Offer Letter, we expressly reserve the right (but will not be obligated), at any time or from time to time, prior to the Expiration Date, regardless of whether or not any of the events set forth above shall have occurred or shall have been determined by us to have occurred, to (a) waive any and all conditions of the Offer, (b) extend the Offer, or (c) otherwise amend the Offer in any respect. The rights reserved by us in this paragraph are in addition to our rights to terminate the Offer described above. Irrespective of any amendment to the Offer, all Warrants previously tendered pursuant to the Offer and not accepted for exchange or withdrawn will remain subject to the Offer and may be accepted thereafter for exchange by us.

If we materially change the terms of the Offer or the information concerning the Offer, or if we waive a material condition to the Offer, we will disseminate additional information and extend the Offer to the extent required by Exchange Act Rules 13e-4(d)(2) and 13e-4(e)(3). In addition, we may, if we deem appropriate, extend the Offer for any other reason. In addition, if the exchange ratio for Shares to Warrants is adjusted, the Offer will remain open at least 10 business days from the date we first give notice of such change to Warrant holders, by press release or otherwise.

Any extension, amendment or termination of the Offer by us will be followed promptly by a public announcement thereof. Without limiting the manner in which we may choose to make such announcement, we will not, unless otherwise required by law, have any obligation to advertise or otherwise communicate any such announcement other than by making a release to the Dow Jones News Service, Globe Newswire or such other means of public announcement as we deem appropriate.

If for any reason the acceptance for exchange (whether before or after any Warrants have been accepted for exchange pursuant to the Offer), or the exchange for, Warrants subject to the Offer is delayed or if we are unable to accept for exchange, or exchange for, Warrants pursuant to the Offer, then, without prejudice to our rights under the Offer, tendered Warrants may be retained by the Depositary on our behalf and may not be withdrawn (subject to Exchange Act Rule 14e-1(c), which requires that an offeror deliver the consideration offered or return the securities deposited by or on behalf of the investor promptly after the termination or withdrawal of a tender offer). In addition to being limited by Exchange Act Rule 14e-1(c), our reservation of the right to delay delivery of the Shares for Warrants which we have accepted for exchange pursuant to the Offer is limited by Exchange Act Rule 13e-4(f)(5),which requires that an offeror deliver the consideration offered or return the securities tendered pursuant to a tender offer promptly after termination or withdrawal of that tender offer. Notwithstanding the foregoing, tendered Warrants may also be withdrawn if the Company has not accepted the Warrants for exchange by the 40 ^th business day after the initial commencement of the Offer.

Pursuant to Exchange Act Rule 13e-4, we have filed the Schedule TO with the SEC which contains additional information with respect to the Offer. The Schedule TO, including the exhibits and any amendments thereto, may be examined, and copies may be obtained, at the same places and in the same manner as set forth under “The Offer – Section 15 – Additional Information; Miscellaneous” in this Offer Letter.

11. MATERIAL U.S. FEDERAL INCOME TAX CONSEQUENCES

The following is a summary of the material U.S. federal income tax consequences to holders that own and hold Warrants as capital assets, within the meaning of Section 1221 of the Internal Revenue Code of 1986, as amended (the “ Code ”), and that exchange Warrants for Shares pursuant to the Offer. This discussion does not address all of the tax consequences that may be relevant to a holder based on its individual circumstances and does not address tax consequences applicable to holders that may be subject to special tax rules, such as: financial institutions; insurance companies; regulated investment companies; tax-exempt organizations; dealers or traders in securities or currencies; holders that actually or constructively own 5% or more of our Shares; holders that hold Warrants as part of a position in a straddle or a hedging, conversion or integrated transaction for U.S. federal income tax purposes; holders that have a functional currency other than the U.S. dollar; holders that received their Warrants as compensation for the performance of services; or holders that are not U.S. persons (within the meaning of Section 7701(a)(30) of the Code). Moreover, this summary does not address any state, local or non-U.S. tax consequences or any U.S. federal non-income tax consequences of the exchange of Warrants for Shares pursuant to the Offer. Holders should consult their tax advisors as to the specific tax consequences to them of the Offer in light of their particular circumstances.

If a partnership (or other entity or arrangement treated as a partnership for U.S. federal income tax purposes) holds Warrants, the tax treatment of a partner in the partnership will generally depend on the status of the partner and the activities of the partnership. Partnerships that hold Warrants, and partners in such partnerships, should consult their tax advisors regarding the U.S. federal income tax consequence of exchanging Warrants for Shares pursuant to the Offer.

This summary is based on the Code, applicable Treasury regulations, administrative pronouncements and judicial decisions, each as in effect on the date hereof. All of the foregoing are subject to change, possibly with retroactive effect, or differing interpretations by the Internal Revenue Service (“ IRS ”) or a court, which could affect the tax consequences described herein.

This summary is included herein as general information only. No statutory or judicial authority directly addresses all aspects of transactions similar to the Offer. We have not sought and do not intend to seek any rulings from the IRS or opinions of counsel regarding the tax consequences described herein, and accordingly, there is no assurance that the IRS will not successfully challenge any of the tax consequences described herein. Accordingly, each Warrant holder is urged to consult its own tax advisor with respect to the U.S. federal, state and local and non-U.S. income and other tax consequences of participating in the Offer.

The exchange of Warrants for Shares pursuant to the Offer should be treated as a “recapitalization” pursuant to which (i) no gain or loss should be recognized on the exchange of Warrants for Shares, (ii) a holder’s aggregate tax basis in the Shares received in the exchange should equal the holder’s aggregate tax basis in its Warrants surrendered in exchange therefor, and (iii) a holder’s holding period for the Shares received in the exchange should include its holding period for the surrendered Warrants. Special tax basis and holding period rules apply to holders that acquired different blocks of Warrants at different prices or at different times. Holders should consult their tax advisors as to the applicability of these special rules to their particular circumstances.

Although the Company believes the tender pursuant to the Offer is not a taxable exchange, the IRS may take a contrary position and assert that the tender gave rise to taxable income. Alternatively, if the IRS or a court were to view the exchange pursuant to the Offer as the issuance of Shares to an exchanging holder having a value in excess of the Warrants surrendered by such holder, such excess value could be viewed as a constructive dividend under Section 305 of the Code. Although not free from doubt, it is expected that such constructive dividend, if any, should be considered a dividend of common stock on common stock, which generally should be nontaxable for most holders.

Holders are urged to consult their personal tax advisors concerning the tax consequences of an exchange pursuant to the Offer based on their particular circumstances.

12. FORWARD-LOOKING STATEMENTS; RISK FACTORS

This Offer Letter contains forward-looking statements as defined in Section 27A of the Securities Act and Section 21E of the Exchange Act. Forward looking statements usually relate to future events, conditions and anticipated revenues, earnings, cash flows or other aspects of our operations or operating results. Forward-looking statements are often identified by the words “believes,” “expects,” “intends,” “estimates,” “projects,” “anticipates,” “will,” “plans,” “may,” “should,” or the negative thereof or similar terms. The absence of these words, however, does not mean that these statements are not forward-looking. These are based on our current expectation, belief and assumptions concerning future developments and business conditions and their potential effect on us. While management believes that these forward-looking statements are reasonable as and when made, there can be no assurance that future development affecting us will be those that we anticipate.

All of our forward-looking statements involve risks and uncertainties (some of which are significant or beyond our control) and assumptions that could cause actual results to differ materially from our historical experience and our present expectations or projections. Known material factors that could cause actual results to differ materially from those contemplated in the forward-looking statements include those set forth in this “Item 12. Forward-Looking Statements; Risk Factors.” We caution you not to place undue reliance on any forward-looking statements, which speak only as of the date hereof. We undertake no obligation to publicly update or revise any of our forward-looking statements after the date they are made, whether as a result of new information, future events, or otherwise, except to the extent required by law.

Among the factors that could cause actual results to differ materially from our forward-looking statements are, without limitation, the following:

An investment in our securities, including the Shares, involves a high degree of risk. In addition to the risks identified below relating to the Offer, please refer to our filings with the SEC, including our Annual Report on Form 10-K for the fiscal year ended December 31, 2018, filed on April 16, 2019, and any of our periodic reports filed pursuant to the Exchange Act thereafter, for a discussion of risks relating to our business and an investment in our securities, including the Shares. Additional risks and uncertainties not presently known to us or that we currently deem immaterial also may impair our business operations. If any of the matters identified as potential risks materialize, our business could be harmed. In that event, the trading price of our Shares could decline. You should consider all such risks before you decide whether to participate in the Offer.

There is no guarantee that your decision whether to tender your Warrants in the Offer will put you in a better future economic position.

We can give no assurance as to the price at which a stockholder may be able to sell his, her or its Shares in the future following the completion of the Offer and the Financing Transaction (including the conversion of all outstanding shares of our Series E Stock and Series F Stock in connection therewith and the effectiveness of the Reverse Split). If you choose to tender your Warrants in the Offer, certain future events (including, without limitation, those described in “The Offer, Section 5.E, Plans, Proposals or Negotiations”), which may be significant and may happen quickly at any time in the future, may result in you realizing a lower value than you might have realized in the future had you not agreed to exchange your Warrants. Similarly, if you do not tender your Warrants in the Offer, you will continue to bear the risk of ownership of your Warrants after the closing of the Offer, and there can be no assurance that you can sell your Warrants (or exercise them for Shares) in the future at a higher price than would have been obtained by participating in the Offer or at all. You should carefully review the terms of the Warrants, and consult your own individual tax and/or financial advisor for assistance on how the tender of your Warrants may affect your individual situation.

There is no guarantee that the Warrants will ever be in the money and they may expire worthless.

The exercise price for the Series E Warrants is $0.50 per Share and the exercise price for the Series F Warrants is $0.55 per Share. While the Warrants have in the past been, and may in the future be, in the money, and it is anticipated that the exercise price of all of the Warrants will be reduced to $0.175 as a result of the Financing Transaction, there is no guarantee that the Warrants will be in the money prior to their expiration, and as such, the Warrants may expire worthless.

Certain members of our board of directors are subject to conflicts of interest with respect to the Offer.

To our knowledge, none of our directors or executive officers beneficially own Warrants, other than Isaac Blech and Donald A. Williams. Further, all of our directors and executive officers, other than Tim Boris, own Shares or securities that are exercisable for or convertible into Shares. The completion of the Offer and the Financing Transaction (including the anticipated conversion of our Series E Stock and Series F Stock into Shares and the effectiveness of the Reverse Split) may impact the trading or market value of the Shares. We did not obtain a “fairness opinion” in connection with the Offer.

The market price of the Shares will fluctuate, which may adversely affect Warrant holders who tender their Warrants for Shares.

The market price of the Shares will fluctuate between the date the Offer is commenced, the Expiration Date of the Offer and the date on which Shares are issued to tendering Warrant holders. Accordingly, the market price of Shares upon settlement of the Offer could be less than the price at which the Warrants could be sold. The Company does not intend to adjust the exchange ratio of Shares for Warrants based on any fluctuation in our Share price.

The issuance of additional Shares upon the exchange of tendered Warrants will dilute our existing stockholders as well as our future shareholders.

We will issue additional Shares upon the exchange of tendered Warrants and upon the anticipated conversion of our Series E Stock and Series F Stock. Shares issued in exchange for Warrants tendered, and upon conversion of our Series E Stock and Series F Stock, will not provide any additional capital to us. These issuances will dilute the ownership by holders of our Shares.

Resales of the additional Shares issued pursuant to the Offer may adversely affect the Share price.

Although the Shares issued to Warrant holders in the Offer (as well as any Shares issued upon the conversion of the Series E Stock and Series F Stock in connection with the Financing Transaction) will be restricted and thus will not be freely tradable, if the holders of such Shares were to sell a meaningful portion of such Shares, or if the market perceives that such sales may occur, then such sales (or perceived sales) could have a negative impact on the trading price of our Shares.

No rulings or opinions have been received as to the tax consequences of the Offer to holders of Warrants.

The tax consequences that will result to Warrant holders that participate in the Offer are not well defined by the existing authorities. No ruling of any governmental authority and no opinion of counsel has been issued or rendered on these matters. Warrant holders must therefore rely on the advice of their own tax advisors in assessing these matters. For a general discussion of certain tax considerations, see “The Offer, Section 11. Material U.S. Federal Income Tax Consequences.”

Should any approval or other action be required, we are unable to predict whether we will delay the closing of the Offer pending the outcome of any such matter.

We are not aware of any license or regulatory permit that is material to our business that might be adversely affected by our acquisition of the Warrants pursuant to the Offer or of any approval or other action by any government or governmental, administrative or regulatory authority or agency, domestic, foreign or supranational, that would be required for our acquisition or ownership of Warrants pursuant to the Offer. Should any approval or other action be required, we are unable to predict whether we will delay the closing of the Offer pending the outcome of any such matter. There can be no assurance that any approval or other action, if needed, would be obtained without substantial cost or conditions or that the failure to obtain the approval or other action might not result in adverse consequences to our business and financial condition.

13. THE DEPOSITARY

We have retained American Stock Transfer & Trust Company to act as the Depositary in connection with the Offer. All deliveries, correspondence and questions sent or presented to the Depositary relating to the Offer should be directed to the address or telephone number set forth on the back cover of this Offer Letter.

14. FEES AND EXPENSES

The Depositary will receive reasonable and customary compensation for its services, will be reimbursed by us for reasonable out-of-pocket expenses and will be indemnified against certain liabilities in connection with the Offer, including certain liabilities under the federal securities laws.

We will not pay any fees or commissions to brokers, dealers or other persons for soliciting tenders of Warrants pursuant to the Offer. Warrant holders holding Warrants through a broker, dealer, commercial bank, trust company or other nominee are urged to consult such nominees to determine whether transaction costs may apply if Warrant holders tender Warrants through such nominees and not directly to the Depositary. We will, however, upon request, reimburse brokers, dealers, commercial banks, trust companies and other nominees for customary mailing and handling expenses incurred by them in forwarding the Offer and related materials to the beneficial owners of Warrants held by them as a nominee or in a fiduciary capacity. No broker, dealer, commercial bank, trust company or other nominee has been authorized to act as our agent or the agent of the Depositary for purposes of the Offer.

15. ADDITIONAL INFORMATION; MISCELLANEOUS

The Company has filed with the SEC a Tender Offer Statement on Schedule TO, of which this Offer Letter is a part. This Offer Letter does not contain all of the information contained in the Schedule TO and the exhibits to the Schedule TO. The Company recommends that holders review the Schedule TO, including the exhibits and the information incorporated by reference in the Schedule TO, and the Company’s other materials that have been filed with the SEC before making a decision on whether to accept the Offer, including:

Documents that we file (but not documents or information deemed to have been furnished and not filed in accordance with the SEC’s rules) with the SEC under Section 13(e), 13(c), 14 or 15(d) of the Exchange Act after the date of this Offer Letter will be incorporated by reference in this Offer Letter only upon our filing of a subsequent amendment to the Schedule TO. Any statement contained in this Offer Letter or in a document (or part thereof) incorporated by reference in this Offer Letter shall be considered to be modified or superseded for purposes of this Offer Letter to the extent that a statement contained in any subsequent amendment to this Offer Letter or amendment to the Schedule TO to which this Offer Letter relates modifies or supersedes that statement.

We are subject to the filing requirements of the Exchange Act. We file reports, proxy statements and other information with the SEC as required by the Exchange Act. You can obtain any of the documents incorporated by reference in this Offer Letter from the SEC’s website at the address described above. You may also request a copy of these filings, at no cost, by writing or telephoning the Company at the telephone number and address set forth below.

Each person to whom a copy of this Offer Letter is delivered may obtain a copy of any or all of the referenced documents, other than exhibits to such documents, unless such exhibits are specifically incorporated by reference into such documents, at no cost. Requests should be directed to our investor relations representative at:

Adhera Therapeutics, Inc.

Attention: Rhonda Stanley

Senior VP of Finance

919-578-5901

rstanley@adherathera.com

Sincerely,

Adhera Therapeutics, Inc.

4721 Emperor Blvd., Suite 350

Durham, North Carolina 27703

The Depositary is American Stock Transfer & Trust Company. The Letter of Transmittal and certificates representing Warrants, and any other required documents should be sent or delivered by each holder of Warrants or such holder’s broker, dealer, commercial bank, trust company or other nominee to the Depositary at its address set forth below.

THE DEPOSITARY FOR THE OFFER IS:

AMERICAN STOCK TRANSFER & TRUST COMPANY

Exhibit (a)(1)(B)

LETTER OF TRANSMITTAL

FOR THE OFFER TO EXCHANGE

BY

ADHERA THERAPEUTICS, INC.

OF CERTAIN OF OUTSTANDING WARRANTS

FOR SHARES OF ITS COMMON STOCK

AT AN EXCHANGE RATIO OF TWO (2) SHARES FOR EACH WARRANT

THE OFFER PERIOD AND WITHDRAWAL RIGHTS WILL EXPIRE AT 5:30 P.M., EASTERN TIME,

ON JUNE 25, 2019 UNLESS THE OFFER PERIOD IS EXTENDED

The undersigned represent(s) that I (we) have full authority to surrender without restriction the warrants that were issued to investors in connection with the private placements of our Series E Convertible Preferred Stock (“ Series E Stock ”) and our Series F Convertible Preferred Stock (“ Series F Stock ”) that were conducted during 2018 (such private placements, the “ Private Placements ”), which warrants are exercisable for shares of Adhera Therapeutics, Inc. common stock, par value $0.006 per share (the “ Shares ”), at an exercise price of $0.50 per Share (subject to adjustment) with respect to the warrants that were issued in connection with the Private Placement of our Series E Stock and at an exercise price of $0.55 per Share (subject to adjustment) with respect to the warrants that were issued in connection with the Private Placement of our Series F Stock (collectively, the “ Warrants ”), for exchange. You are hereby authorized and instructed to prepare in the name of and deliver to the address indicated below (unless otherwise instructed in the boxes in the following page) a certificate representing Shares for Warrants tendered pursuant to this Letter of Transmittal. Such Shares shall equal two (2) Shares per Warrant tendered, subject to adjustment in the event a fractional Share would be issued, as described in the Offer Letter, dated May 28, 2019.

The Company is relying on Rule 506(b) of Regulation D promulgated under the Securities Act of 1933, as amended (the “Securities Act”), to exempt the Offer from the registration requirements of the Securities Act. The Company is also relying on the applicable provisions of Section 18(b)(4) of the Securities Act to exempt the Offer from the registration and qualification requirements of state securities laws. The Company has no contract, arrangement or understanding relating to the payment of, and will not, directly or indirectly, pay, any commission or other remuneration to any broker, dealer, salesperson, agent or any other person for soliciting tenders in the Offer. In addition, none of the Depositary or any broker, dealer, salesperson, agent or any other person is engaged or authorized to express any statement, opinion, recommendation or judgment with respect to the relative merits and risks of the Offer. The Company’s officers and directors may solicit tenders from holders of the Warrants and will answer inquiries concerning the terms of the Offer, but they will not receive additional compensation for soliciting tenders or answering any such inquiries.

All share and per share information included in this Letter of Transmittal shall be appropriately adjusted to give effect to any split or combination of the Shares that may become effective prior to the completion of the Offer, including the one-for-two reverse split of the Shares that the Company intends to effect prior to, and as a condition of, the closing of the Offer.

Method of delivery of the Warrant(s) is at the option and risk of the owner thereof.

See Instruction 2.

Mail or deliver this Letter of Transmittal, or a facsimile, together with the certificate(s) representing your Warrants, to:

PLEASE READ THIS ENTIRE LETTER OF TRANSMITTAL CAREFULLY,

INCLUDING THE ACCOMPANYING INSTRUCTIONS

Ladies and Gentlemen:

The undersigned hereby exchanges the below described Warrants of Adhera Therapeutics, Inc. (the “ Company ”), a Delaware corporation, pursuant to the Company’s Offer to Exchange Letter dated May 28, 2019 (the “ Offer Letter ”) and this Letter of Transmittal (which together, as they may be further amended or supplemented from time to time, constitute the “ Offer ”).

The Board of Directors of the Company has extended the Offer to all holders of the Company’s issued and outstanding warrants that were issued to investors in connection with the private placements of the Company’s Series E Convertible Preferred Stock (“ Series E Stock ”) and the Company’s Series F Convertible Preferred Stock (“ Series F Stock ”) that were conducted during 2018 (such private placements, the “ Private Placements ”), which warrants are exercisable for shares of the Company’s common stock, par value $0.006 per share (the “ Shares ”), at an exercise price of $0.50 per Share (subject to adjustment) with respect to the warrants that were issued in connection with the Private Placement of Series E Stock and $0.55 per Share (subject to adjustment) with respect to the warrants that were issued in connection with the Private Placement of Series F Stock (collectively, the “ Warrants ”), to permit holders of Warrants to tender outstanding Warrants in exchange for Shares at an exchange ratio of two (2) Shares for each Warrant tendered, subject to adjustment, as described in the Offer Letter.

NO FRACTIONAL SHARES WILL BE ISSUED. WARRANTS MAY ONLY BE EXCHANGED FOR WHOLE SHARES. IN LIEU OF ISSUING FRACTIONAL SHARES TO WHICH ANY HOLDER OF WARRANTS WOULD OTHERWISE HAVE BEEN ENTITLED, THE COMPANY WILL ROUND THE NUMBER OF SHARES TO WHICH SUCH HOLDER IS ENTITLED, AFTER AGGREGATING ALL FRACTIONS, UP TO THE NEAREST WHOLE NUMBER OF SHARES.

WARRANTS NOT EXCHANGED FOR SHARES WILL REMAIN SUBJECT TO THEIR ORIGINAL TERMS AND SHALL EXPIRE IN ACCORDANCE WITH THEIR ORIGINAL TERMS.

THE OFFER RELATES TO THE WARRANTS ISSUED TO INVESTORS IN CONNECTION WITH THE PRIVATE PLACEMENTS, WHICH WARRANTS ARE NOT LISTED OR TRADED ON ANY EXCHANGE OR OTHER PLATFORM. THE OFFER DOES NOT RELATE TO ANY OTHER WARRANTS THAT HAVE BEEN ISSUED BY THE COMPANY. ANY AND ALL OUTSTANDING WARRANTS ARE ELIGIBLE TO BE TENDERED PURSUANT TO, AND SUBJECT TO THE TERMS AND CONDITIONS OF, THE OFFER.

Subject to and effective upon acceptance of the tender of the Warrants exchanged hereby in accordance with the terms and subject to the conditions of the Offer (including, if the Offer is extended or amended, the terms and conditions of such extension or amendment), the undersigned hereby agrees to subscribe for the Shares, upon the exchange of one (1) Warrant for two (2) Shares, as indicated on the first page of this Letter of Transmittal.

The undersigned acknowledges that the undersigned has been advised to consult with its own advisors as to the consequences of participating or not participating in the Offer.

The undersigned hereby represents and warrants to the Company that:

(a) the undersigned has full power and authority to tender the Warrants tendered hereby and subscribe for all of the Shares of the Company which may be received upon exchange of the Warrants tendered hereby;

(b) the undersigned has good, marketable and unencumbered title to the Warrants tendered hereby, free and clear of all security interests, liens, restrictions, charges, encumbrances, conditional sales agreements or other obligations relating to their exchange, sale or transfer, and the Warrants tendered hereby are not subject to any adverse claim;

(c) on request, the undersigned will execute and deliver any additional documents the Company deems necessary to complete the exchange of the Warrants tendered hereby;

(d) the undersigned understands that tenders of Warrants tendered hereby pursuant to the Offer and in the instructions hereto will constitute the undersigned’s acceptance of the terms and conditions of the Offer;

(e) the undersigned is an “accredited investor” as that term is defined in Regulation D promulgated under the Securities Act of 1933, as amended; and

(f) the undersigned agrees to all of the terms of the Offer.

All authorities conferred or agreed to be conferred in this Letter of Transmittal shall survive the death or incapacity of the undersigned, and any obligation of the undersigned hereunder shall be binding upon the heirs, personal representatives, executors, administrators, successors, assigns, trustees in bankruptcy, and legal representatives of the undersigned. Except as stated in the Offer, this tender is irrevocable.

Delivery of this Letter of Transmittal and all other documents to an address, or transmission of instructions to a facsimile number, other than as set forth above, does not constitute a valid delivery. Please read carefully the entire Letter of Transmittal, including the accompanying instructions, before checking any box below. This Letter of Transmittal is to be used if certificates are to be forwarded herewith.

If you desire to exchange Warrants pursuant to the Offer and you cannot deliver your Warrant certificate(s) and all other documents required by this Letter of Transmittal are delivered to the depositary prior to the Expiration Date, you may tender your Warrants according to the delivery procedures set forth in the Offer Letter under “The Offer, Section 2. Procedure for Tendering Warrants.” See Instruction 2.

Delivery of documents to the Company does not constitute delivery to American Stock Transfer & Trust Company (the “ Depositary ”).

“Expiration Date” means 5:30 p.m., Eastern Time, on Tuesday, June 25, 2019, unless and until the Company, in its sole discretion, extends the Offer, in which case the “Expiration Date” means the latest time and date at which the Offer, as extended, expires.

THE UNDERSIGNED UNDERSTANDS THAT ACCEPTANCE OF WARRANTS BY THE COMPANY FOR EXCHANGE WILL CONSTITUTE A BINDING AGREEMENT BETWEEN THE UNDERSIGNED AND THE COMPANY UPON THE TERMS AND SUBJECT TO THE CONDITIONS OF THE OFFER.

NOTE: SIGNATURES MUST BE PROVIDED BELOW.

PLEASE READ THE ACCOMPANYING INSTRUCTIONS CAREFULLY.

This Letter of Transmittal is to be completed by a holder of Warrants if Warrant Certificates are to be forwarded with this Letter of Transmittal. Delivery of documents to the Company does not constitute delivery to the Depositary .

The undersigned hereby: (i) elects to exchange the Warrants described under “Election to Exchange” below (Box 1); and (ii) agrees to subscribe for the Shares issuable thereunder, in each case pursuant to the terms and subject to the conditions described in the Offer Letter and this Letter of Transmittal. Subject to, and effective upon, the Company’s acceptance of the undersigned’s election to exchange the Warrants described in Box 1 below, the undersigned hereby assigns and transfers to, or upon the order of, the Company, all right, title and interest in, to, and under the Warrants being exchanged hereby, waives any and all other rights with respect to such Warrants and releases and discharges the Company from any and all claims the undersigned may have now, or may have in the future, arising out of, or related to, such Warrants.

The undersigned hereby irrevocably constitutes and appoints the Depositary as the true and lawful agent and attorney-in-fact of the undersigned with respect to the Warrants the undersigned is electing to exchange, with full power of substitution (the power of attorney being deemed to be an irrevocable power coupled with an interest), to deliver the Warrants the undersigned is electing to exchange to the Company or cause ownership of such Warrants to be transferred to, or upon the order of, the Company, on the books of the Depositary and deliver all accompanying evidences of transfer and authenticity to, or upon the order of, the Company upon receipt by the Company’s Depositary, as the undersigned’s agent, of the Shares to which the undersigned is entitled upon acceptance by the Company of the undersigned’s election to exchange Warrants pursuant to the Offer.

Unless otherwise indicated under “Special Issuance Instructions” below (Box 2), please issue the Shares for the exchanged Warrants in the name(s) of the undersigned. Similarly, unless otherwise indicated under “Special Delivery Instructions” below (Box 3), please send or cause to be sent the certificates for the Shares (and accompanying documents, as appropriate) to the undersigned at the address shown above under “Description of Warrants Tendered” (on the cover page of this Letter of Transmittal) or to the account with the Depositary as indicated herein.

The undersigned understands that elections to exchange Warrants pursuant to the procedures described under “The Offer, Section 2. Procedure for Tendering Warrants” in the Offer Letter and in the instructions to this Letter of Transmittal will constitute a binding agreement between the undersigned and the Company upon the terms of the Offer set forth in the Offer Letter under “The Offer, Section 1. General Terms,” and subject to the conditions of the Offer set forth in the Offer Letter under “The Offer, Section 10. Conditions; Termination; Waivers; Extensions; Amendments,” subject only to withdrawal of elections to exchange on the terms set forth in the Offer Letter under “The Offer, Section 3. Withdrawal Rights.” All authority conferred in this Letter of Transmittal or agreed to be conferred will survive the death, bankruptcy or incapacity of the undersigned , and every obligation of the undersigned under this Letter of Transmittal will be binding upon the heirs, personal representatives, executors, administrators, successors, assigns, trustees in bankruptcy and other legal representatives of the undersigned.

The undersigned hereby represents and warrants that it has full power and authority to exchange, assign and transfer the Warrants the undersigned has elected to exchange pursuant to this Letter of Transmittal. The undersigned will, upon request, execute and deliver any additional documents reasonably requested by the Company or the Depositary as necessary or desirable to complete and give effect to the transactions contemplated hereby.

NOTE: SIGNATURES MUST BE PROVIDED BELOW.

PLEASE READ THE ACCOMPANYING INSTRUCTIONS CAREFULLY BEFORE COMPLETING THE BOXES.

INSTRUCTIONS

FORMING PART OF THE TERMS AND CONDITIONS OF THE OFFER

1. GUARANTEE OF SIGNATURE.

No signature guarantee is required if either:

(a) this Letter of Transmittal is signed by the registered holder of the Warrants exactly as the name of the registered holder appears on the certificate tendered with this Letter of Transmittal and such owner has not completed the box entitled “Special Delivery Instructions” or “Special Issuance Instructions”; or

(b) such Warrants are tendered for the account of a member firm of a registered national securities exchange, a member of the Financial Industry Regulatory Authority (“ FINRA ”) or a commercial bank or trust company (not a savings bank or savings and loan association) having an office, branch or agency in the United States which is a participant in an approved Signature Guarantee Medallion Program (each such entity, an “Eligible Institution ”); or

(c) the holders of such Warrants reside outside of the U.S. and are not otherwise tendering the Warrants in the U.S.

In all other cases, an Eligible Institution must guarantee all signatures on this Letter of Transmittal. See Instruction 5.

2. DELIVERY OF LETTER OF TRANSMITTAL AND CERTIFICATES.

This Letter of Transmittal is to be used if certificates for Warrants are delivered with it to the Depositary.

When completing this Letter of Transmittal: (a) a properly completed and duly executed Letter of Transmittal or duly executed and manually signed facsimile copy of it, in accordance with the instructions of the Letter of Transmittal (including any required signature guarantees), (b) certificates for the Warrants being exchanged, and (c) any other documents required by the Letter of Transmittal, should be mailed or delivered to the Depositary at the appropriate address set forth on the front page of this document and must be received by the Depositary prior to the expiration of the Offer. If certificates are forwarded to the Depositary in multiple deliveries, a properly completed and duly executed Letter of Transmittal must accompany each such delivery.

The method of delivery of all documents, including Warrant certificates, the Letter of Transmittal and any other required documents, is at the election and risk of the tendering Warrant holder, and the delivery will be deemed made only when actually received by the Depositary. If delivery is by mail, registered mail with return receipt requested, properly insured, is recommended. In all cases, sufficient time should be allowed to ensure timely delivery.

Except as specifically permitted by the Offer Letter, no alternative or contingent exchanges will be accepted.

3. INADEQUATE SPACE. If the space provided in the box captioned “Description of Warrants Tendered” is inadequate, the certificate number(s) and the number of Warrants should be listed on a separate signed schedule and attached to this Letter of Transmittal.

4. WARRANTS EXCHANGED. Warrant holders who choose to participate in the Offer must exchange all, but not less than all, of such holder’s Warrants pursuant to the terms of the Offer, as described in the Offer Letter.

5. SIGNATURES ON LETTER OF TRANSMITTAL .

(a) If this Letter of Transmittal is signed by the registered holder(s) of the Warrants tendered hereby, the signature(s) must correspond exactly with the name(s) as written on the face of the certificate(s) without any change whatsoever.

(b) If the Warrants are held of record by two or more persons or holders, all such persons or holders must sign this Letter of Transmittal.

(c) If any tendered Warrants are registered in different names on several certificates, it will be necessary to complete, sign and submit as many separate Letters of Transmittal (or photocopies of it) as there are different registrations of certificates.

(d) When this Letter of Transmittal is signed by the registered holder(s) of the Warrants listed and transmitted hereby, no endorsement(s) of certificate(s) representing such Warrants or separate instruments of transfer are required. EXCEPT AS OTHERWISE PROVIDED IN INSTRUCTION 1, SIGNATURE(S) ON SUCH CERTIFICATE(S) MUST BE GUARANTEED BY AN ELIGIBLE INSTITUTION. If this Letter of Transmittal is signed by a person other than the registered holder(s) of the certificate(s) listed, the certificate(s) must be endorsed or accompanied by appropriate instruments of transfer, in either case signed exactly as the name(s) of the registered holder(s) appears on the certificate(s), and the signature(s) on such certificate(s) or instruments of transfer must be guaranteed by an Eligible Institution. See Instruction 1.

(e) If this Letter of Transmittal or any certificate(s) or instruments of transfer are signed by trustees, executors, administrators, guardians, attorneys-in-fact, officers of corporations or others acting in a fiduciary or representative capacity, such persons should so indicate when signing and must submit proper evidence satisfactory to the Company of the authority so to act. If the certificate has been issued in the fiduciary or representative capacity, no additional documentation will be required.

6. SPECIAL DELIVERY AND SPECIAL ISSUANCE INSTRUCTIONS. If certificates for Shares issued upon exchange of the Warrants are to be issued in the name of a person other than the signer of the Letter of Transmittal or if such certificates are to be sent to someone other than the person signing the Letter of Transmittal or to the signer at a different address, the boxes captioned “Special Issuance Instructions” and/or “Special Delivery Instructions” on this Letter of Transmittal must be completed as applicable and signatures must be guaranteed as described in Instruction 1.

7. IRREGULARITIES. All questions as to the number of Warrants to be accepted, the validity, form, eligibility (including time of receipt) and acceptance of any tender of Warrants will be determined by the Company in its sole discretion, which determinations shall be final and binding on all parties, subject to the judgment of any court that might provide otherwise. The Company reserves the absolute right to reject any or all tenders of Warrants it determines not to be in proper form or to reject those Warrants, the acceptance of which may, in the opinion of the Company’s counsel, be unlawful, subject to the judgment of any court that might provide otherwise. The Company also reserves the absolute right to waive any of the conditions of the Offer (subject to the potential requirement to disseminate additional information and extend the Offer, as described in the Offer Letter under “The Offer, Section 10. Conditions; Termination; Waivers; Extensions; Amendments”) and any defect or irregularity in the tender of any particular Warrant, and the Company’s interpretation of the terms of the Offer (including these instructions) will be final and binding on all parties, subject to the judgment of any court that might provide otherwise. No tender of Warrants will be deemed to be properly made until all defects and irregularities have been cured or waived. Unless waived, any defects or irregularities in connection with tenders must be cured within such time as the Company shall determine. Neither the Company nor any other person is or will be obligated to give notice of any defects or irregularities in tenders, and none of them will incur any liability for failure to give any such notice.

8. SUBSTITUTE FORM W-9 AND FORM W-8. To avoid backup withholding, a tendering Warrant holder is required to provide the Depositary with a correct Taxpayer Identification Number (“ TIN ”) on Substitute Form W-9, which is provided herewith, and to certify, under penalties of perjury, that such number is correct and that such Warrant holder is not subject to backup withholding of U.S. federal income tax, and that such Warrant holder is a U.S. person (as defined for U.S. federal income tax purposes). If a tendering Warrant holder has been notified by the Internal Revenue Service (“ IRS ”) that such Warrant holder is subject to backup withholding, such Warrant holder must cross out item (2) of the Certification box of the Substitute Form W-9, unless such Warrant holder has since been notified by the IRS that such Warrant holder is no longer subject to backup withholding. Failure to provide the information on the Substitute Form W-9 may subject the tendering Warrant holder to U.S. federal income tax withholding if any cash payments are made in lieu of fractional shares; however, no such cash payments will be made. If the tendering Warrant holder has not been issued a TIN and has applied for one or intends to apply for one in the near future, such Warrant holder should check the box in Part 3 of the Substitute Form W-9, and sign and date the Substitute Form W-9. If the box in Part 3 is checked and the Depositary is not provided with a TIN by the time of payment, the Depositary will withhold a portion of all payments to such Warrant holder until a TIN is provided to the Depositary.

Certain Warrant holders (including, among others, all corporations and certain foreign individuals and entities) may not be subject to backup withholding. Foreign Warrant holders should submit an appropriate and properly completed IRS Form W-8, a copy of which may be obtained from the Depositary, in order to avoid backup withholding. Such Warrant holders should consult a tax advisor to determine which Form W-8 is appropriate. See the enclosed “Guidelines for Certification of Taxpayer Identification Number on Substitute Form W-9” for more instructions.

9. QUESTIONS AND REQUESTS FOR ASSISTANCE AND ADDITIONAL COPIES. Please direct questions or requests for assistance, or for additional copies of the Offer Letter, Letter of Transmittal or other materials, to the Company at:

Adhera Therapeutics, Inc.

4721 Emperor Boulevard, Suite 350

Durham, North Carolina 27703

919-578-5901

IMPORTANT: THIS LETTER OF TRANSMITTAL (OR A PHOTOCOPY THEREOF) TOGETHER WITH WARRANT CERTIFICATES AND ALL OTHER REQUIRED DOCUMENTS MUST BE RECEIVED BY THE DEPOSITARY ON OR PRIOR TO 5:30 P.M., EASTERN TIME, ON TUESDAY, JUNE 25, 2019.

IMPORTANT TAX INFORMATION

Under U.S. federal income tax law, a Warrant holder who is a U.S. person (as defined for U.S. federal income tax purposes) surrendering Warrants must, unless an exemption applies, provide the Depositary (as payer) with the Warrant holder’s correct TIN on IRS Form W-9 or on the Substitute Form W-9 included in this Letter of Transmittal. If the Warrant holder is an individual, the Warrant holder’s TIN is such Warrant holder’s Social Security number. If the correct TIN is not provided, the Warrant holder may be subject to a $50 penalty imposed by the IRS.

Certain Warrant holders (including, among others, corporations and certain foreign individuals and entities) may not be subject to backup withholding and reporting requirements. In order for an exempt foreign Warrant holder to avoid backup withholding, such person should complete, sign and submit an appropriate Form W-8 signed under penalties of perjury, attesting to his or her foreign status. A Form W-8 can be obtained from the Depositary. Such Warrant holders should consult a tax advisor to determine which Form W-8 is appropriate. Exempt Warrant holders, other than foreign Warrant holders, should furnish their TIN, check the box in Part 4 of the Substitute Form W-9 and sign, date and return the Substitute Form W-9 to the Depositary in order to avoid erroneous backup withholding. See the enclosed “Guidelines for Certification of Taxpayer Identification Number on Substitute Form W-9” for additional instructions.

If backup withholding applies, the Depositary is required to withhold and pay over to the IRS a portion of any payment made to a Warrant holder. Backup withholding is not an additional tax. Rather, the U.S. federal income tax liability of persons subject to backup withholding will be reduced by the amount of tax withheld. If backup withholding results in an overpayment of taxes, a refund may be obtained from the IRS.

Purpose of Substitute Form W-9

To prevent backup withholding on payments that are made to a Warrant holder with respect to Shares issued pursuant to the Offer, the Warrant holder is required to notify the Depositary of the Warrant holder’s correct TIN by completing the Substitute Form W-9 included in this Letter of Transmittal certifying (1) that the TIN provided on the Substitute Form W-9 is correct (or that such Warrant holder is awaiting a TIN), (2) that the Warrant holder is not subject to backup withholding because (i) the Warrant holder is exempt from backup withholding, (ii) the Warrant holder has not been notified by the IRS that the Warrant holder is subject to backup withholding as a result of a failure to report all interest and dividends or (iii) the IRS has notified the Warrant holder that the Warrant holder is no longer subject to backup withholding and (3) the Warrant holder is a U.S. person (as defined for U.S. federal income tax purposes).

What Number to Give the Depositary

The tendering Warrant holder is required to give the Depositary the TIN, generally the Social Security number or Employer Identification Number, of the record holder of the Warrants tendered hereby. If the Shares are in more than one name or are not in the name of the actual owner, consult the enclosed “Guidelines for Certification of Taxpayer Identification Number on Substitute Form W-9” for additional guidance on which number to report. If the tendering Warrant holder has not been issued a TIN and has applied for a number or intends to apply for a number in the near future, such Warrant holder should check the box in Part 3 of the Substitute Form W-9, sign and date the Substitute Form W-9 and sign and date the Certificate of Awaiting Taxpayer Identification Number, which appears in a separate box below the Substitute Form W-9. If the box in Part 3 of the Substitute Form W-9 is checked and the Depositary is not provided with a TIN by the time of payment, the Depositary will withhold a portion of all payments of the purchase price until a TIN is provided to the Depositary. If the Depositary is provided with an incorrect TIN in connection with such payments, the Warrant holder may be subject to a $50.00 penalty imposed by the IRS.