UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 8-K
Current Report
Pursuant to Section 13 or 15(d) of
the Securities Exchange Act of 1934
Date of Report (Date of earliest event reported): December 19, 2022
ADAPTIMMUNE THERAPEUTICS PLC
(Exact name of registrant as specified in its charter)
England and Wales | 1-37368 | |||
(State or other jurisdiction of | (Commission File Number) | (IRS Employer Identification No.) |
60 Jubilee Avenue, Milton Park
Abingdon, Oxfordshire OX14 4RX
United Kingdom
(Address of principal executive offices, including zip code)
(44) 1235 430000
(Registrant’s telephone number, including area code)
Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions:
☐Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)
☐Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)
☐Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))
☐Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))
Securities registered pursuant to Section 12(b) of the Act:
Title of each class | Trading Symbol | Name of each exchange on which | ||
American Depositary Shares, each representing 6 Ordinary Shares, par value £0.001 per share | ADAP | The Nasdaq Global Select Market |
Indicate by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 (§230.405 of this chapter) or Rule 12b-2 of the Securities Exchange Act of 1934 (§240.12b-2 of this chapter).
Emerging growth company ☐
If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act.☐
Item 1.01. Entry into a Material Definitive Agreement.
On October 24, 2022 Adaptimmune Therapeutics plc (“Adaptimmune”) received notice of termination of the Collaboration and License Agreement (“Collaboration Agreement”) between Adaptimmune Limited and GlaxoSmithKline Intellectual Property Development Ltd (“GSK”) dated May 30, 2014. On December 19, 2022 and as a result of such termination, Adaptimmune and GSK entered into Amendment Agreement No. 8 (the “Amendment”) further amending the Collaboration Agreement. The Amendment deleted Section 13.6.9 of the Collaboration Agreement relating to GSK’s post termination manufacturing and supply obligations in consideration for the payment of £5 million by GSK to Adaptimmune and clarified that no additional milestones are due under the Collaboration Agreement. The Amendment also clarified the allocation of responsibilities between GSK and Adaptimmune with respect to the transfer of information relating to the manufacturing process for the collaboration product targeting NY-ESO (lete-cel) and information relating to the collaboration program directed to the PRAME target to Adaptimmune. Further elements of the transfer of the NY-ESO and PRAME programs and any remaining payments are subject to further negotiation and a future agreement between the parties.
Item 9.01 Financial Statements and Exhibits.
(d) Exhibits.
Exhibit No. |
| Description of Exhibit |
10.1† | ||
104 | Cover Page Interactive Date File (embedded within the Inline XBRL document) |
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†Certain portions of this exhibit have been omitted because they are not material and they are the type of information that the registrant treats as private or confidential.
SIGNATURES
Pursuant to the requirements of the Securities Exchange Act of 1934, as amended, the registrant has duly caused this report to be signed on its behalf by the undersigned, hereunto duly authorized.
ADAPTIMMUNE THERAPEUTICS PLC | |||
Date: December 20, 2022 | By: | /s/ Margaret Henry | |
Name: | Margaret Henry | ||
Title: | Corporate Secretary |
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Exhibit 10.1
certain identified information CONTAINED IN THIS EXHIBIT, MARKED BY [***], HAS BEEN EXCLUDED FROM THIS EXHIBIT because it is both not material and is the type that the registrant treats as private or confidential
AMENDMENT AGREEMENT NO. 8
THIS AMENDMENT AGREEMENT is made and effective as of 19th December 2022 (the “Amendment Effective Date”)
BETWEEN
1. | Adaptimmune Limited a company incorporated in the United Kingdom under number 06456741 whose registered office is at 60 Jubilee Avenue, Milton Park |
2. | GlaxoSmithKline Intellectual Property Development Ltd whose registered office is at 980 Great West Road, Middlesex, TW8 9GS, United Kingdom (“GSK”). |
BACKGROUND
(A) | GSK and Adaptimmune entered into a Collaboration and Licence Agreement with effective date of May 30, 2014, which was amended by Amendment Agreement No 1 (with Amendment Effective date of 08 May 2015) and Amendment Agreement No. 2 (with Amendment Effective date of 02 February 2016), Amendment Agreement No. 3 (with Amendment Effective date of 29 September 2016), Amendment Agreement No. 4 dated 11 November 2016, Amendment Agreement No. 5 (with Amendment Effective date of 7 September 2017), Amendment Agreement No. 6 (with Amendment Effective Date 20 July 2018 and Amendment Agreement No. 7 (with Amendment Effective Date 6 December 2019) (the “Collaboration Agreement”). |
(B) | On 24 October 2022, in accordance with Section 13.2 of the Collaboration Agreement, GSK delivered notice of termination of the Collaboration Agreement to Adaptimmune, which termination is effective on 23 December 2022 (the “Termination Effective Date”). |
(C) | Section 13.6 of the Collaboration Agreement sets forth the effects of termination. |
1. | DEFINITIONS |
1.1 | In this Amendment Agreement words and expressions shall have the same meaning |
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as set out in the Collaboration Agreement save as explicitly provided otherwise in this section 1.1 or elsewhere in this Amendment Agreement: |
1.2 | In this Amendment Agreement: |
1.2.1 | References to sections and clauses are to sections and clauses of this Amendment Agreement unless otherwise provided; |
1.2.2 | Headings are used for convenience only and do not affect interpretation of the terms; |
1.2.3 | (a) the word “including” shall be deemed to be followed by the phrase “without limitation” or like expression; (b) the singular shall include the plural and vice versa; and (c) masculine, feminine and neuter pronouns and expressions shall be interchangeable; and |
1.2.4 | References to a statutory provision include references to the statutory provision as modified or re-enacted or both from time to time and to any subordinate legislation made under the statutory provision. |
1.3 | “GSK Manufacturing Know-How” means GSK Background solely owned or Controlled by GSK or its Affiliates and related to or required for the operation of the Manufacturing Process, [***]. |
1.4 | “Manufacturing Process” means the manufacturing processes used by GSK in the manufacture of (a) pivotal study supply of the Terminated Product known as Letetresgene Autoleucel or GSK3377794 (“lete-cel”), (b) clinical supply of the Terminated Product known as GSK3901961 (“CD8 NYESO Product”) and (c) clinical supply of the Terminated Product known as GSK3845097 (“TGF NYESO Product”). Lete-cel, CD8 NYESO Product and TGF NYESO Product are collectively referred to herein as the “NYESO Terminated Products”. |
2. | EFFECT OF AMENDMENTS |
2.1 | The amendments set out in section 4 below shall come into effect on the Amendment Effective Date and shall amend the Collaboration Agreement as from the Amendment Effective Date. |
2.2 | Save as explicitly amended by this Amendment Agreement, the Collaboration Agreement will continue in full force and effect in accordance with the terms set forth therein. In the event of a conflict of terms between this Amendment Agreement and the Collaboration Agreement, the terms of this Amendment Agreement shall control. |
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3. | EFFECTS OF TERMINATION |
3.1 | The Parties have tentatively agreed on the general scope of transition of the NYESO Terminated Products and PRAME Terminated Product (as defined below) from GSK to Adaptimmune, as set forth on the slides attached hereto as Exhibit 2. This Amendment Agreement relates only to certain activities relating to the manufacture and supply of Terminated Products, payment in consideration for the termination of GSK’s obligation to manufacture and supply Terminated Product and certain activities relating to the PRAME Terminated Product. The Parties will use reasonable efforts to negotiate and enter into a further agreement setting forth in detail the terms and conditions of the transition of remaining activities relating to the NY-ESO Terminated Products and PRAME Terminated Product. The agreement will include the detailed transfer plan referred to in Section 4.3, [***]. The Parties will use reasonable efforts to enter into such agreement no later than [***]. |
3.2 | Notwithstanding Section 13.6.3, the license granted to GSK under Section 6.6.1 of the Collaboration Agreement shall continue on a non-exclusive basis solely for the purpose of permitting GSK to carry out any activities required under Section 13.6 after the Termination Effective Date. |
4. | AMENDMENTS |
Manufacturing Post-Termination
4.1 | Section 13.6.9 is hereby deleted from the Collaboration Agreement in its entirety and GSK will have no obligation to manufacture and supply to Adaptimmune any further Terminated Product save as explicitly set out in this Amendment Agreement. |
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4.4 | Commencing on the Amendment Effective Date, GSK grants to Adaptimmune a non-exclusive, royalty-free, sublicensable, fully paid up, worldwide license to the GSK Manufacturing Know-How solely to make, have made, import, use, offer for sale, and sell lete-cel or any products incorporating the TCR from lete-cel (whether alone or in combination with other components or active moieties) in the Field. Such license shall terminate upon the cessation of the development and commercialization of lete-cel or product incorporating the TCR from lete-cel by Adaptimmune, its Affiliates or sublicensees. |
4.5 | During the period commencing on the Amendment Effective Date and ending [***] (the “Advisory Period”), GSK shall be available for, and shall provide reasonable consultation, knowledge transfer and advice to Adaptimmune as reasonably required for Adaptimmune to understand the Manufacturing Process in anticipation of Adaptimmune’s continuing manufacture of lete-cel, and to exercise the license rights set forth in Section 4.4. [***]. |
4.6 | Upon delivery of the Additional Materials relating to the Manufacturing Process and |
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4.8 | Following the expiration of the Advisory Period, for so long as GSK is continuing to provide lete-cel and CD8 NYESO Product to patients under Section 4.7(b) above and in connection with the dosing of such patients, or in connection with any long-term follow up of patients dosed with any Terminated Product, [***]. |
Milestones
4.9 | The Parties agree that no Milestone Fees are now due, or will be due, from GSK to Adaptimmune under the Collaboration Agreement. The Parties also agree that the provisions of Section 13.7 shall not apply to NYESO Terminated Products or the PRAME Terminated Product. |
5. | GENERAL |
5.1 | This Amendment Agreement is governed by and shall be construed in accordance with English law. |
5.2 | This Amendment Agreement together with the Collaboration Agreement (incorporating all schedules and exhibits) constitutes the entire agreement between the Parties relating to its subject matter. Each Party acknowledges that it has not entered into this Amendment Agreement on the basis of any warranty, representation, statement, agreement or undertaking except those expressly set out in this Amendment |
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Agreement or the Collaboration Agreement (as amended). Each Party waives any claim for breach of this Amendment Agreement, or any right to rescind this Amendment Agreement in respect of, any representation which is not an express provision of this Amendment Agreement together with the Collaboration Agreement (as amended). Nothing in this clause excludes any liability which either Party may have to the other (or any right which either Party may have to rescind this Amendment Agreement) in respect of any fraudulent misrepresentation or fraudulent concealment prior to the execution of this Amendment Agreement. |
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The Parties agree to enter into, and be bound by, this Amendment Agreement by their duly authorised representatives as of the Amendment Effective Date.
SIGNED for and on behalf of ADAPTIMMUNE LIMITED:
……/s/ Helen Tayton-Martin…..... (signature)
…………CBO………………….. (position)
……Helen Tayton-Martin………. (name)
SIGNED for and on behalf of GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED:
…/s/ Marcus Dowding…..... (signature)
Authorised Signatory of Edinburgh Pharmaceutical Industries Limited, Corporate Division…………………………….. (position)
…Marcus Dowding……………………. (name)
Amendment Agreement Signature Page
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Exhibit 1
● | [***] |
● | [***] |
● | [***] |
[***].
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Exhibit 2
[***]
[THIS PAGE AND THE FOLLOWING 16 PAGES OF THIS EXHIBIT HAVE BEEN EXCLUDED FROM THIS EXHIBIT because it is both not material and is the type that the registrant treats as private or confidential]