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Delaware
(State or other jurisdiction of
incorporation or organization)
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45‑4870634
(I.R.S. Employer
Identification No.)
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780 Memorial Drive
Cambridge, Massachusetts
(Address of principal executive offices)
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02139
(Zip Code)
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Title of each class
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Name of each exchange on which registered
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Common Stock, $0.001 par value per share
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Nasdaq Global Select Market
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Large accelerated filer
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Accelerated filer
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Non‑accelerated filer
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x
(Do not check if a smaller reporting company)
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Smaller reporting company
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¨
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Emerging growth company
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x
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the timing, progress, and results of preclinical studies and clinical trials for JTX-2011, JTX-4014 and any product candidates we may develop, including statements regarding the timing of initiation and completion of studies or trials and related preparatory work, the period during which the results of the trials will become available, and our research and development programs;
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the timing, scope, or likelihood of regulatory filings and approvals, including, as applicable, timing of our Investigational New Drug Application for, Biologics License Application filing for, and final Food and Drug Administration approval of JTX-2011, JTX-4014 and any product candidates we may develop;
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our ability to use our Translational Science Platform to identify targets for future product candidates and to match immunotherapies to select patient subsets;
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our ability to identify, develop and advance any future product candidates into, and successfully complete, clinical studies;
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our ability to develop combination therapies, whether on our own or in collaboration with Celgene Corporation, or Celgene, and other third parties, for JTX-2011 and JTX-4014;
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our expectations regarding the size of the patient populations for JTX-2011 and JTX-4014, if approved for commercial use, and any product candidates we may develop;
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our commercialization and marketing capabilities and strategy;
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the pricing and reimbursement of JTX-2011, JTX-4014 and any product candidates we may develop, if approved;
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the implementation of our business model and our strategic plans for our business, JTX-2011, JTX-4014 and any product candidates we may develop, and our technology;
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our ability to develop and commercialize a companion diagnostic or complementary diagnostic for JTX-2011, JTX-4014 and any product candidates we may develop;
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the rate and degree of market acceptance and clinical utility of JTX-2011, JTX-4014 and any product candidates we may develop;
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the potential benefits of and our ability to maintain our collaboration with Celgene, and establish or maintain future collaborations or strategic relationships or obtain additional funding;
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our ability to retain the continued service of our key professionals and to identify, hire and retain additional qualified professionals;
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our intellectual property position, including the scope of protection we are able to establish and maintain for intellectual property rights covering JTX-2011, JTX-4014 and any product candidates we may develop, and our ability not to infringe, misappropriate or otherwise violate any third-party intellectual property rights;
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our competitive position, and developments and projections relating to our competitors and our industry;
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our estimates regarding expenses, future revenue, capital requirements and needs for additional financing;
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the impact of laws and regulations; and
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our expectations regarding the time during which we will be an emerging growth company under the JOBS Act.
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Aggressively develop our product candidates, and subsequent candidates, using biomarker-driven adaptive trial designs aimed at bringing the right immunotherapy to the right patients;
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Continue our investment in our Translational Science Platform to enhance our deep understanding of the TME, as we look to broaden the benefit of immunotherapy through targeting additional cell types;
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Address the unmet need of cancer patients with tumors unresponsive to T effector cell-directed therapies by focusing our discovery efforts on other cell types within the TME; and
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Expand our pipeline by leveraging our internal discovery platform and/or in-licensing new technologies and methodologies to turn cold tumors into hot tumors to make them more amenable to immunotherapy.
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Certain indications, for example melanoma, appear to be more immuno-responsive than others.
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As these agents move to earlier lines of treatment, response rates increase, however, it is still only a minority of patients who benefit from monotherapy.
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Response rates may be increased by the use of biomarkers to select patients who may be more likely to benefit from immunotherapies.
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We will retain 60 percent of the U.S. operating profits or losses arising from commercialization of JTX-2011, with 40 percent allocated to Celgene.
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We will retain 25 percent of the U.S. operating profits or losses arising from commercialization of the first program, other than JTX-2011 or JTX-4014, for which an IND application is filed under the collaboration, with 75 percent allocated to Celgene. Celgene has a one-time right to substitute and swap the economics and governance of this program with that of another program for which it exercises an option (other than JTX-2011 and JTX-4014).
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We and Celgene will equally share U.S. operating profits or losses arising from commercialization of up to three additional programs (other than JTX-2011 or JTX-4014).
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We and Celgene will share all development costs, other than for JTX-4014, in accordance with the applicable co-development and co-commercialization agreement.
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traditional cancer therapies, including chemotherapy;
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two anti-ICOS antibody programs in clinical trials, the first being developed by GlaxoSmithKline plc, for which patient enrollment in a Phase I trial began in the second quarter of 2016 and the second being developed by Bristol Myers Squibb Company, for which patient enrollment in a Phase I/II trial began in the third quarter of 2017;
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approved immunotherapy antibodies, including an approved anti-CTLA 4 antibody (Yervoy, marketed by Bristol Myers Squibb Company) and approved anti-PD-1/anti-PD-L1 antibodies (Opdivo, Keytruda, Tecentriq, Bavencio and Imfizi, marketed by Bristol Myers Squibb Company, Merck & Co., Genentech, Inc., Merck KGaA and Pfizer Inc. and AstraZeneca PLC, respectively);
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anti-PD-1/anti-PD-L1 immunotherapy antibodies in clinical development;
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other agonist immunotherapy antibodies in clinical development; and
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therapies targeting macrophages, T regulatory cells and B cells that are in clinical development.
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completion of extensive preclinical studies in accordance with applicable regulations, including studies conducted in accordance with good laboratory practice, or GLP, requirements;
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submission to the FDA of an IND application, which must become effective before human clinical trials may begin;
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approval by an independent institutional review board, or IRB, or ethics committee at each clinical trial site before each trial may be initiated;
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performance of adequate and well-controlled human clinical trials in accordance with applicable IND regulations, good clinical practice, or GCP, requirements and other clinical trial-related regulations to establish the safety and efficacy of the investigational product for each proposed indication;
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submission to the FDA of an NDA or BLA;
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determination by the FDA within 60 days of its receipt of an NDA or BLA to accept the filing for review;
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satisfactory completion of an FDA pre-approval inspection of the manufacturing facility or facilities where the drug or biologic will be produced to assess compliance with current good manufacturing practices, or cGMP, requirements to assure that the facilities, methods and controls are adequate to preserve the drug or biologic’s identity, strength, quality and purity;
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potential FDA audit of the preclinical and/or clinical trial sites that generated the data in support of the NDA or BLA; and
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FDA review and approval of the NDA or BLA, including consideration of the views of any FDA advisory committee, prior to any commercial marketing or sale of the drug or biologic in the United States.
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Phase I clinical trials generally involve a small number of healthy volunteers or disease-affected patients who are initially exposed to a single dose and then multiple doses of the product candidate. The primary purpose of these clinical trials is to assess the metabolism, pharmacologic action, side effect tolerability and safety of the drug.
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Phase II clinical trials involve studies in disease-affected patients to determine the dose required to produce the desired benefits. At the same time, safety and further PK and PD information is collected, possible adverse effects and safety risks are identified and a preliminary evaluation of efficacy is conducted.
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Phase III clinical trials generally involve a large number of patients at multiple sites and are designed to provide the data necessary to demonstrate the effectiveness of the product for its intended use, its safety in use and to establish the overall benefit/risk relationship of the product and provide an adequate basis for product approval. These trials may include comparisons with placebo and/or other comparator treatments. The duration of treatment is often extended to mimic the actual use of a product during marketing.
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successful completion of preclinical studies of JTX-4014 and any future product candidates;
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successful completion of non-clinical toxicology studies that may be required for regulatory approval of JTX-2011;
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acceptance of INDs for our planned clinical trials or future clinical trials;
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successful enrollment and completion of clinical trials;
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demonstration of a benefit/risk profile for JTX-2011, JTX-4014 and any other future product candidates that is sufficient to support a successful BLA;
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successful development and marketing approval and clearance of complementary diagnostics and/or companion diagnostics for use with JTX-2011, JTX-4014 or any other future product candidates, if applicable;
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receipt and maintenance of marketing approvals from applicable regulatory authorities;
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approval by national pricing and reimbursement agencies (such as NICE, National Institute for Health Care and Excellence in the United Kingdom);
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establishing agreements with third-party manufacturers for clinical supply for our clinical trials and commercial manufacturing, if our product candidate is approved;
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obtaining and maintaining patent and trade secret protection or regulatory exclusivity for our product candidates;
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launching commercial sales of JTX-2011, JTX-4014 or any other future product candidates, if and when approved;
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acceptance of our product candidates, if and when approved, by patients, the medical community and third-party payors;
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effectively competing with other therapies;
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obtaining and maintaining healthcare coverage and adequate reimbursement;
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enforcing and defending intellectual property rights and claims;
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successful completion of clinical confirmatory trials to verify clinical benefit, if applicable; and
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maintaining a continued acceptable safety profile of the product candidates following approval.
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regulators, IRBs, or ethics committees may not authorize us or our investigators to commence a clinical trial or conduct a clinical trial at a prospective trial site;
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we may experience delays in reaching, or fail to reach, agreement on acceptable terms with prospective trial sites and prospective contract research organizations, or CROs;
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clinical trials may produce negative or inconclusive results, and we may decide, or regulators may require us, to conduct additional preclinical studies or clinical trials or abandon product development programs;
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the number of patients required for clinical trials may be larger than we anticipate;
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it may be difficult to enroll a sufficient number of patients with a predictive biomarker or enrollment in these clinical trials may be slower than we anticipate or participants may drop out of these clinical trials or fail to return for post-treatment follow-up at a higher rate than we anticipate;
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our third-party contractors may fail to comply with regulatory requirements or meet their contractual obligations to us in a timely manner, or at all, or may deviate from the clinical trial protocol or drop out of the trial, which may require that we add new clinical trial sites or investigators;
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we may elect to, or regulators or IRBs or ethics committees may require that we or our investigators, suspend or terminate clinical research for various reasons, including noncompliance with regulatory requirements or a finding that the participants are being exposed to unreasonable and significant health risks;
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the cost of clinical trials may be greater than we anticipate;
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the supply or quality of materials or other materials necessary to conduct clinical trials may be insufficient or inadequate;
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the size of the patient population required to validate our JTX-2011 predictive biomarker strategy may be larger than we anticipate;
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competitors may obtain regulatory approval ahead of us for compounds similar to ours, preventing us from obtaining regulatory approval despite positive clinical data;
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our product candidates may have undesirable side effects or other unexpected characteristics, causing us to suspend or terminate the trials, or reports may arise from preclinical or clinical testing of other similar cancer therapies that raise safety or efficacy concerns about our product candidates; and
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the FDA or other regulatory authorities may require us to submit additional data or impose other requirements before permitting us to initiate or continue a clinical trial.
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be delayed in obtaining marketing approval for our product candidates;
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not obtain marketing approval at all;
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obtain approval for indications or patient populations that are not as broad as intended or desired;
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be subject to post-marketing testing requirements; or
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have the product removed from the market after obtaining marketing approval.
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the patient eligibility criteria defined in the protocol;
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our ability to identify and enroll sufficient number of patients with a predictive biomarker;
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the size of the patient population required for analysis of the trial’s primary endpoints;
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the proximity of patients to study sites;
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the design of the trial;
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our ability to recruit clinical trial investigators with the appropriate competencies and experience;
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clinicians’ and patients’ perceptions of the potential advantages of the product candidate being studied in relation to other available therapies;
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our ability to obtain and maintain patient consents for participation in our clinical trials and, where appropriate, biopsies for future patient enrichment efforts; and
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the risk that patients enrolled in clinical trials will drop out of the trials before completion or, because they are late-stage cancer patients, will not survive the full terms of the clinical trials.
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untitled and warning letters;
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civil or criminal penalties and fines;
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injunctions;
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suspension or withdrawal of marketing approval;
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suspension of any ongoing clinical trials;
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product recalls;
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refusal to accept or approve BLAs or supplements thereto filed by us;
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restrictions on operations, including costly new manufacturing requirements; or
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seizure or detention of our products or import bans.
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a product candidate may not be deemed safe or effective;
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FDA officials may not find the data from preclinical studies and clinical trials sufficient;
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the FDA might not deem our or our third-party manufacturers’ processes or facilities adequate for approval of our marketing applications; or
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the FDA may change its approval policies or adopt new regulations.
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restrictions on the marketing or manufacturing of our product candidates, withdrawal of the product from the market, or product recalls;
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fines, untitled and warning letters, or holds on clinical trials;
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refusal by the FDA to approve pending applications or supplements to approved applications we filed or suspension or revocation of license approvals;
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product seizure or detention, or refusal to permit the import or export of our product candidates; and
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injunctions or the imposition of civil or criminal penalties.
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Collaborators have significant discretion in determining the efforts and resources that they will apply to these collaborations. For example, under our collaboration agreement with Celgene, development and commercialization plans and strategies for licensed programs will be conducted in accordance with a plan approved by the appropriate committee comprised of representatives from both us and Celgene.
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Collaborators, including Celgene, may not pursue development and commercialization of JTX-2011, JTX-4014 or any future product candidates or may elect not to continue or renew development or commercialization programs based on clinical trial results, changes in their strategic focus due to the acquisition of competitive products, availability of funding or other external factors such as a business combination that diverts resources or creates competing priorities.
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Collaborators may delay clinical trials, provide insufficient funding for a clinical trial program, stop a clinical trial, abandon a product candidate, repeat or conduct new clinical trials or require a new formulation of a product candidate for clinical testing. For example, under our collaboration agreement with Celgene, at any point in the research, development and clinical trial process, or during the term of any applicable co-
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Collaborators could independently develop, or develop with third parties, products that compete directly or indirectly with our products or product candidates.
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A collaborator with marketing and distribution rights to one or more products may not commit sufficient resources to their marketing and distribution.
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Collaborators may own or co-own intellectual property covering our products that results from our collaborating with them, and in such cases, we would not have the exclusive right to develop, commercialize, enforce, maintain or defend such intellectual property.
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Collaborators may not properly enforce, maintain or defend our intellectual property rights or may use our proprietary information in a way that gives rise to actual or threatened litigation that could jeopardize or invalidate our intellectual property or proprietary information or expose us to potential litigation, or other intellectual property proceedings. For example, under certain limited circumstances, Celgene has the first right to enforce, maintain or defend our intellectual property rights under our collaboration arrangement with respect to certain licensed programs and, although we may have the right to assume the enforcement, maintenance and defense of our intellectual property rights if Celgene does not, our ability to do so may be compromised by Celgene’s actions.
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Disputes may arise between a collaborator and us that cause the delay or termination of the research, development or commercialization of JTX-2011, JTX-4014 and any other future product candidates, or that result in costly litigation or arbitration that diverts management attention and resources. For example, although we and Celgene have agreed to the form of co-development and co-commercialization agreement and license agreement to be entered into should Celgene exercise its option for a program under the Celgene Collaboration Agreement, we may never come to agreement with Celgene on a final definitive agreement. Further, even if we do reach a definitive agreement, it may not be on terms that are as favorable to us as expected.
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Collaborations may be terminated and, if terminated, may result in a need for additional capital to pursue further development or commercialization of the applicable product candidates. For example, Celgene can terminate its agreement with us, in its entirety or with respect to any program, upon 120 days’ notice and can terminate the entire agreement with us in connection with a material breach of the agreement by us that remains uncured for 90 days. If Celgene exercises such termination right, we may not have sufficient resources to continue the development of such product candidate.
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Collaboration agreements may not lead to development or commercialization of product candidates in the most efficient manner or at all.
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Collaboration agreements may restrict our right to independently pursue new product candidates. For example, if Celgene exercises its option for a program within the collaboration other than JTX-4014, then until termination or expiration of the applicable co-development and co-commercialization agreement for such program, we may not directly or indirectly research, develop, manufacture or commercialize, outside of the collaboration, any biologic medicine or product candidate with specified activity against that program’s collaboration target.
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an inability to continue clinical trials of JTX-2011 or initiate or continue clinical trials of JTX-4014 or any other future product candidates under development;
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delay in submitting regulatory applications, or receiving marketing approvals, for JTX-2011, JTX-4014 or any other future product candidates;
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loss of cooperation of an existing or future collaborator;
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subjecting third-party manufacturing facilities or our manufacturing facilities to additional inspections by regulatory authorities; and
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requirements to cease distribution or to recall batches of JTX-2011, JTX-4014 and any other future product candidates.
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We do not have the capability internally to manufacture drug products or drug substances for clinical use. We use third-party manufacturers for manufacturing JTX-2011 for our Phase I/II study of JTX-2011. Any changes in our manufacturing processes as a result of scaling-up may require additional approvals or may delay the development and marketing approval of JTX-2011, JTX-4014 and any other future product candidates and ultimately affect our success.
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The manufacturing facilities in which JTX-2011, JTX-4014 or any other future product candidates are made could be adversely affected by equipment failures, contamination, vendor error, labor shortages, natural disasters, power failures and numerous other factors.
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Any adverse developments affecting manufacturing operations for JTX-2011, JTX-4014 or any other future product candidates, if any are approved, may result in shipment delays, inventory shortages, lot failures, product withdrawals or recalls, or other interruptions in the supply of our products. We may also have to take inventory write-offs and incur other charges and expenses for products that fail to meet specifications, undertake costly remediation efforts or seek more costly manufacturing alternatives.
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Biologics, such as JTX-2011, that have been produced and are stored for later use may degrade, become contaminated, suffer other quality defects or may not be used within their shelf life, which may cause the affected product candidates to no longer be suitable for their intended use in clinical trials or other development activities. If the defective product candidates cannot be replaced in a timely fashion, we may incur significant delays in our development programs that could adversely affect the value of such product candidates.
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the development of JTX-2011, JTX-4014 and any other future product candidates may be adversely affected if we are unable to appropriately select patients for enrollment in our clinical trials;
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JTX-2011, JTX-4014 and any other future product candidates may not receive marketing approval if safe and effective use of a product candidate depends on a complementary diagnostics and/or companion diagnostics and such diagnostic is not commercially available or otherwise approved or cleared by the appropriate regulatory authority; and
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we may not realize the full commercial potential of JTX-2011, JTX-4014 and any other future product candidates that receive marketing approval if, among other reasons, we are unable to appropriately identify, or it takes us longer to identify, patients who are likely to benefit from therapy with our products, if approved.
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decreased demand for our product candidates;
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injury to our reputation;
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withdrawal of clinical trial participants;
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initiation of investigations by regulators;
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costs to defend the related litigation;
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a diversion of management’s time and our resources;
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substantial monetary awards to trial participants or patients;
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product recalls, withdrawals or labeling, marketing or promotional restrictions;
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loss of revenue;
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exhaustion of any available insurance and our capital resources;
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the inability to commercialize any product candidate; and
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a decline in our share price.
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completing clinical development of our lead product candidate, JTX-2011, and completing research and discovery and preclinical and clinical development of any other programs and product candidates;
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obtaining marketing approvals for JTX-2011, JTX-4014 and any future product candidates for which we complete clinical trials;
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developing a sustainable and scalable manufacturing process for our product candidates, including establishing and maintaining commercially viable supply and manufacturing relationships with third parties;
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launching and commercializing our product candidates for which we obtain marketing approvals, either directly or with a collaborator or distributor;
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obtaining market acceptance of JTX-2011, JTX-4014 and any future product candidates as viable treatment options;
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addressing any competing technological and market developments;
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identifying, assessing, acquiring and developing new product candidates;
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negotiating favorable terms in any collaboration, licensing, or other arrangements into which we may enter;
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obtaining, maintaining, protecting, and expanding our portfolio of intellectual property rights, including patents, trade secrets, and know-how; and
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attracting, hiring, and retaining qualified personnel.
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the scope, progress, results and costs of researching and developing our product candidates, and conducting preclinical studies and clinical trials;
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the timing of, and the costs involved in, obtaining marketing approvals for our product candidates if clinical trials are successful;
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the success of our collaboration with Celgene;
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whether Celgene exercises its licensing and co-development options under our collaboration agreement with Celgene, each of which would trigger additional payments to us;
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the cost of commercialization activities for our product candidates, that are approved for sale, including marketing, sales and distribution costs;
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the cost of manufacturing our product candidates for clinical trials in preparation for marketing approval and in preparation for commercialization;
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our ability to establish and maintain strategic licensing or other arrangements and the financial terms of such agreements;
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the costs involved in preparing, filing, prosecuting, maintaining, expanding, defending and enforcing patent claims, including litigation costs and the outcome of such litigation;
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the timing, receipt, and amount of sales of, or royalties on, our future products, if any;
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the emergence of competing cancer therapies and other adverse market developments; and
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the requirement for and cost of developing complementary diagnostics and/or companion diagnostics.
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identifying, recruiting, integrating, maintaining and motivating additional employees;
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managing our internal development efforts effectively, including the clinical and FDA review process for JTX-2011, JTX-4014 and any other future product candidates, while complying with our contractual obligations to contractors and other third parties; and
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improving our operational, financial and management controls, reporting systems and procedures.
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increased operating expenses and cash requirements;
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the assumption of additional indebtedness or contingent liabilities;
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the issuance of our equity securities;
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assimilation of operations, intellectual property and products of an acquired company, including difficulties associated with integrating new personnel;
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the diversion of our management’s attention from our existing product programs and initiatives in pursuing such a strategic merger or acquisition;
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retention of key employees, the loss of key personnel, and uncertainties in our ability to maintain key business relationships;
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risks and uncertainties associated with the other party to such a transaction, including the prospects of that party and their existing products or product candidates and marketing approvals; and
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our inability to generate revenue from acquired technology and/or products sufficient to meet our objectives in undertaking the acquisition or even to offset the associated acquisition and maintenance costs.
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the success of competitive products or technologies;
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results of our clinical trials or those of our competitors;
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regulatory or legal developments in the United States and other countries;
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developments or disputes concerning patent applications, issued patents or other proprietary rights;
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the recruitment or departure of key personnel;
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the level of expenses related to our product candidates or clinical development programs;
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the results of our efforts to discover, develop, acquire or in-license additional product candidates or drugs;
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actual or anticipated changes in estimates as to financial results, development timelines or recommendations by securities analysts;
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variations in our financial results or those of companies that are perceived to be similar to us;
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changes in the structure of healthcare payment systems;
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market conditions in the pharmaceutical and biotechnology sectors;
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general economic, industry and market conditions; and
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the other factors described in this “Risk factors” section.
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delaying, deferring or preventing a change of control;
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impeding a merger, consolidation, takeover or other business combination; or
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discouraging a potential acquiror from making a tender offer or otherwise attempting to obtain control.
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the timing and cost of, and level of investment in, research and development activities relating to our current and any future product candidates, which will change from time to time;
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our ability to enroll patients in clinical trials and the timing of enrollment;
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the cost of manufacturing our current and any future product candidates, which may vary depending on FDA guidelines and requirements, the quantity of production and the terms of our agreements with manufacturers;
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expenditures that we will or may incur to acquire or develop additional product candidates and technologies;
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the timing and outcomes of clinical studies for JTX-2011, JTX-4014 and any other future product candidates or competing product candidates;
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•
|
competition from existing and future products that may compete with JTX-2011, JTX-4014 and any other future product candidates, and changes in the competitive landscape of our industry, including consolidation among our competitors or partners;
|
•
|
any delays in regulatory review or approval of JTX-2011, JTX-4014 or any other future product candidates;
|
•
|
the level of demand for JTX-2011, JTX-4014 and any other future product candidates, if approved, which may fluctuate significantly and be difficult to predict;
|
•
|
our ability to commercialize JTX-2011, JTX-4014 and any other future product candidates, if approved;
|
•
|
the success of our collaboration with Celgene and our ability to establish and maintain other collaborations, licensing or other arrangements;
|
•
|
our ability to adequately support future growth;
|
•
|
potential unforeseen business disruptions that increase our costs or expenses;
|
•
|
future accounting pronouncements or changes in our accounting policies; and
|
•
|
the changing and volatile global economic environment.
|
•
|
addition and retention of key research and development personnel;
|
•
|
establishing an appropriate safety profile with IND-enabling toxicology studies;
|
•
|
the cost to acquire or make therapies to study in combination with our immunotherapies;
|
•
|
successful enrollment in and completion of clinical trials;
|
•
|
establishing agreements with third-party manufacturers for clinical supply for our clinical trials and commercial manufacturing, if our product candidates are approved;
|
•
|
receipt of marketing approvals from applicable regulatory authorities;
|
•
|
commercializing products, if and when approved, whether alone or in collaboration with others;
|
•
|
the cost to develop complementary diagnostics and/or companion diagnostics as needed for each of our development programs;
|
•
|
the costs associated with the development of any additional product candidates we acquire through third-party collaborations or identify through our Translational Science Platform;
|
•
|
the terms and timing of any collaboration, license or other arrangement, including the terms and timing of any milestone payments thereunder;
|
•
|
obtaining and maintaining patent and trade secret protection and regulatory exclusivity for our products if and when approved; and
|
•
|
continued acceptable safety profiles of the products following approval.
|
|
Year Ended December 31,
|
||||||||||
(in thousands)
|
2017
|
|
2016
|
|
2015
|
||||||
JTX-2011
|
$
|
21,904
|
|
|
$
|
8,887
|
|
|
$
|
4,682
|
|
JTX-4014
|
6,460
|
|
|
1,481
|
|
|
—
|
|
|||
Pre-development candidates
|
1,619
|
|
|
1,111
|
|
|
1,409
|
|
|||
Total external research and development and clinical and regulatory costs
|
$
|
29,983
|
|
|
$
|
11,479
|
|
|
$
|
6,091
|
|
•
|
continue our adaptive Phase I/II clinical trial with JTX-2011;
|
•
|
continue to identify and test potential combination agents to be studied with JTX-2011;
|
•
|
continue our IND enabling activities for JTX-4014 and advance this program into clinical trials for use in combination with our potential product candidates;
|
•
|
continue to develop and identify potential predictive biomarkers and complementary diagnostics and/or companion diagnostics for JTX-2011 and other potential product candidates;
|
•
|
continue to develop and enhance our Translational Science Platform and advance our early stage pipeline of immunotherapy programs including early research activities under our Celgene collaboration into later stages of development; and
|
•
|
increase our headcount to meet our evolving needs.
|
•
|
persuasive evidence of an arrangement exists;
|
•
|
delivery has occurred or services have been rendered;
|
•
|
the seller’s price to the buyer is fixed or determinable; and
|
•
|
collectability is reasonably assured.
|
•
|
the lack of an active public market for our common and our convertible preferred stock;
|
•
|
the prices of shares of our convertible preferred stock that we had sold to outside investors in arm’s length transactions, and the rights, preferences and privileges of that convertible preferred stock relative to our common stock;
|
•
|
our results of operations, financial position and the status of our research and preclinical development efforts;
|
•
|
the material risks related to our business;
|
•
|
our business strategy;
|
•
|
the market performance of publicly traded companies in the life sciences and biotechnology sectors;
|
•
|
the likelihood of achieving a liquidity event for the holders of our common stock, such as an initial public offering given prevailing market conditions; and
|
•
|
any recent contemporaneous valuation of our common stock prepared in accordance with methodologies outlined in the Practice Aid.
|
|
Year Ended December 31,
|
|
|
||||||||
(in thousands)
|
2017
|
|
2016
|
|
$ Change
|
||||||
Revenue:
|
|
|
|
|
|
|
|
|
|||
Collaboration revenue—related party
|
$
|
71,644
|
|
|
$
|
37,197
|
|
|
$
|
34,447
|
|
Operating expenses:
|
|
|
|
|
|
|
|
||||
Research and development
|
67,798
|
|
|
34,904
|
|
|
32,894
|
|
|||
General and administrative
|
23,061
|
|
|
16,759
|
|
|
6,302
|
|
|||
Total operating expenses
|
90,859
|
|
|
51,663
|
|
|
39,196
|
|
|||
Other income, net
|
2,808
|
|
|
763
|
|
|
2,045
|
|
|||
Loss before provision for income taxes
|
(16,407
|
)
|
|
(13,703
|
)
|
|
(2,704
|
)
|
|||
Provision for income taxes
|
36
|
|
|
—
|
|
|
36
|
|
|||
Net loss
|
$
|
(16,443
|
)
|
|
$
|
(13,703
|
)
|
|
$
|
(2,740
|
)
|
|
Year Ended December 31,
|
|
|
||||||||
(in thousands)
|
2017
|
|
2016
|
|
$ Change
|
||||||
Employee compensation
|
$
|
18,839
|
|
|
$
|
13,569
|
|
|
$
|
5,270
|
|
External research and development
|
16,297
|
|
|
7,617
|
|
|
8,680
|
|
|||
External clinical and regulatory
|
13,686
|
|
|
3,862
|
|
|
9,824
|
|
|||
Lab consumables
|
9,364
|
|
|
4,813
|
|
|
4,551
|
|
|||
Consulting research
|
1,096
|
|
|
1,025
|
|
|
71
|
|
|||
Facility costs
|
6,127
|
|
|
2,782
|
|
|
3,345
|
|
|||
Other research
|
2,389
|
|
|
1,236
|
|
|
1,153
|
|
|||
Total research and development expenses
|
$
|
67,798
|
|
|
$
|
34,904
|
|
|
$
|
32,894
|
|
•
|
$5.3 million
of increased employee compensation costs primarily attributable to increased headcount, offset by
$1.3 million
of decreased stock-based compensation expense related to the achievement of milestones during the
year ended
December 31, 2016
which triggered vesting of certain outstanding awards granted to non-employees;
|
•
|
$8.7 million
of increased external research and development costs primarily attributable to the manufacture of pre-commercial clinical trial materials and related activities for JTX-2011, IND enabling activities related to JTX-4014 and external costs associated with our early discovery programs;
|
•
|
$9.8 million
of increased external clinical and regulatory costs related to our JTX-2011 adaptive Phase I/II clinical trial, which commenced enrollment in August 2016;
|
•
|
$4.6 million
of increased lab consumables costs primarily attributable to our increased research and development activities;
|
•
|
$3.3 million
of increased facility costs, including expenses associated with the exit of our previous corporate headquarters, increased rent expense related to our new corporate headquarters, depreciation and maintenance costs; and
|
•
|
$1.2 million
of increased other research costs, including travel-related expenses, software license costs, information technology expenses and achievement of certain development and technical milestones related to our license and collaboration agreements.
|
|
Year Ended December 31,
|
|
|
||||||||
(in thousands)
|
2017
|
|
2016
|
|
$ Change
|
||||||
Employee compensation
|
$
|
9,055
|
|
|
$
|
6,228
|
|
|
$
|
2,827
|
|
Consulting
|
2,257
|
|
|
1,711
|
|
|
546
|
|
|||
Legal fees
|
1,384
|
|
|
2,007
|
|
|
(623
|
)
|
|||
Facility costs
|
5,216
|
|
|
2,130
|
|
|
3,086
|
|
|||
Other
|
5,149
|
|
|
2,638
|
|
|
2,511
|
|
|||
Write-off of IPO costs
|
—
|
|
|
2,045
|
|
|
(2,045
|
)
|
|||
Total general and administrative expenses
|
$
|
23,061
|
|
|
$
|
16,759
|
|
|
$
|
6,302
|
|
•
|
$2.8 million
of increased employee compensation costs primarily attributable to increased headcount, of which
$1.1 million
related to increased stock-based compensation expense, as well as increased recruiting costs;
|
•
|
$3.1 million
of increased facility costs, including expenses associated with the exit of our previous corporate headquarters, increased rent expense related to our new corporate headquarters, depreciation and maintenance costs; and
|
•
|
$2.5 million
of increased other costs primarily attributable to operating as a public company as well as increased headcount.
|
•
|
$0.6 million
of decreased legal fees due to non-litigation related legal costs incurred in 2016 in connection with our business development activities; and
|
•
|
$2.0 million
of legal and accounting costs written off during the year ended December 31, 2016 as a result of the postponement of our IPO. The IPO was originally postponed for a period significantly in excess of 90 days, and as a result, the previously-capitalized costs were written off to general and administrative expenses.
|
|
Year Ended December 31,
|
|
|
||||||||
(in thousands)
|
2016
|
|
2015
|
|
$ Change
|
||||||
Revenue:
|
|
|
|
|
|
|
|
|
|||
Collaboration revenue—related party
|
$
|
37,197
|
|
|
$
|
—
|
|
|
$
|
37,197
|
|
Operating expenses:
|
|
|
|
|
|
|
|
||||
Research and development
|
34,904
|
|
|
22,130
|
|
|
12,774
|
|
|||
General and administrative
|
16,759
|
|
|
8,266
|
|
|
8,493
|
|
|||
Total operating expenses
|
51,663
|
|
|
30,396
|
|
|
21,267
|
|
|||
Other income, net
|
763
|
|
|
5
|
|
|
758
|
|
|||
Other financing income, net
|
—
|
|
|
1,859
|
|
|
(1,859
|
)
|
|||
Net loss
|
(13,703
|
)
|
|
(28,532
|
)
|
|
14,829
|
|
|
Year Ended December 31,
|
|
|
||||||||
(in thousands)
|
2016
|
|
2015
|
|
$ Change
|
||||||
Employee compensation
|
$
|
13,569
|
|
|
$
|
7,259
|
|
|
$
|
6,310
|
|
External research and development
|
7,617
|
|
|
6,091
|
|
|
1,526
|
|
|||
External clinical and regulatory
|
3,862
|
|
|
—
|
|
|
3,862
|
|
|||
Lab consumables
|
4,813
|
|
|
4,972
|
|
|
(159
|
)
|
|||
Consulting research
|
1,025
|
|
|
1,254
|
|
|
(229
|
)
|
|||
Facility costs
|
2,782
|
|
|
1,953
|
|
|
829
|
|
|||
Other research
|
1,236
|
|
|
601
|
|
|
635
|
|
|||
Total research and development expenses
|
$
|
34,904
|
|
|
$
|
22,130
|
|
|
$
|
12,774
|
|
•
|
$6.3 million
of increased employee compensation costs primarily attributable to increased headcount, including $1.8 million of stock-based compensation expense related to the achievement of milestones during the
year ended
December 31, 2016
which triggered vesting of certain outstanding awards granted to non-employees;
|
•
|
$1.5 million
of increased external research and development costs primarily attributable to the completion of IND enabling activities for JTX-2011, commencement of IND enabling activities related to JTX-4014 and external costs associated with our early discovery programs;
|
•
|
$3.9 million
of increased external clinical and regulatory costs related to our JTX-2011 Phase I/II clinical trial, which commenced enrollment in August 2016; and
|
•
|
$0.8 million
of increased facility costs, including rent, utilities, depreciation and maintenance costs.
|
|
Year Ended December 31,
|
|
|
||||||||
(in thousands)
|
2016
|
|
2015
|
|
$ Change
|
||||||
Employee compensation
|
$
|
6,228
|
|
|
$
|
3,779
|
|
|
$
|
2,449
|
|
Consulting
|
1,711
|
|
|
771
|
|
|
940
|
|
|||
Legal fees
|
2,007
|
|
|
661
|
|
|
1,346
|
|
|||
Facility costs
|
2,130
|
|
|
1,472
|
|
|
658
|
|
|||
Other
|
2,638
|
|
|
1,583
|
|
|
1,055
|
|
|||
Write-off of IPO costs
|
2,045
|
|
|
—
|
|
|
2,045
|
|
|||
Total general and administrative expenses
|
$
|
16,759
|
|
|
$
|
8,266
|
|
|
$
|
8,493
|
|
•
|
$2.4 million
of increased employee compensation costs primarily attributable to increased headcount;
|
•
|
$0.9 million
of increased consulting costs, including external recruiting, accounting and tax services;
|
•
|
$1.3 million
of increased legal fees primarily attributable to non-litigation related legal costs incurred in 2016 in connection with our business development activities;
|
•
|
$0.7 million
of increased facility costs, including rent, utilities, depreciation and maintenance costs;
|
•
|
$1.1 million
of increased other costs, including information technology, audit and tax services; and
|
•
|
$2.0 million
of legal and accounting costs written off in 2016 as a result of the postponement of our IPO. The IPO was originally postponed for a period significantly in excess of 90 days, and as a result, the previously-capitalized costs were written off to general and administrative expenses.
|
•
|
the timing and progress of preclinical and clinical development activities;
|
•
|
the cost to access, acquire, or develop therapies to study in combination with our immunotherapies;
|
•
|
successful enrollment in and completion of clinical trials;
|
•
|
the cost to develop complementary diagnostics and/or companion diagnostics as needed for each of our development programs;
|
•
|
our ability to establish agreements with third-party manufacturers for clinical supply for our clinical trials and, if our product candidate is approved, commercial manufacturing;
|
•
|
the costs associated with the development of any additional product candidates we acquire through acquisition, third-party collaborations or identify through our Translational Science Platform;
|
•
|
our ability to maintain our current research and development programs and enhancement of our Translational Science Platform;
|
•
|
addition and retention of key research and development personnel;
|
•
|
our efforts to enhance operational, financial and information management systems, and hire additional personnel, including personnel to support development of our product candidates;
|
•
|
the legal patent costs involved in prosecuting patent applications and enforcing patent claims and other intellectual property claims;
|
•
|
the costs and ongoing investments to in-license or acquire additional technologies, including the in-license of intellectual property related to our potential product candidates, the effectiveness of which is subject to certain conditions; and
|
•
|
the terms and timing of any collaboration, license or other arrangement, including the terms and timing of any milestone payments thereunder.
|
|
Year Ended December 31,
|
||||||||||
(in thousands)
|
2017
|
|
2016
|
|
2015
|
||||||
Net cash (used in) provided by:
|
|
|
|
|
|
|
|
||||
Operating activities
|
$
|
(90,738
|
)
|
|
$
|
179,688
|
|
|
$
|
(25,739
|
)
|
Investing activities
|
(38,021
|
)
|
|
(215,508
|
)
|
|
(2,142
|
)
|
|||
Financing activities
|
107,470
|
|
|
35,507
|
|
|
70,704
|
|
|||
Net (decrease) increase in cash and cash equivalents
|
$
|
(21,289
|
)
|
|
$
|
(313
|
)
|
|
$
|
42,823
|
|
•
|
pertain to the maintenance of records that in reasonable detail accurately and fairly reflect the transactions and dispositions of a company’s assets;
|
•
|
provide reasonable assurance that transactions are recorded as necessary to permit preparation of financial statements in accordance with generally accepted accounting principles, and that a company’s receipts and expenditures are being made only in accordance with authorizations of the company’s management and directors; and
|
•
|
provide reasonable assurance regarding prevention or timely detection of unauthorized acquisition, use or disposition of our assets that could have a material effect on the financial statements.
|
|
December 31,
|
||||||
|
2017
|
|
2016
|
||||
Assets:
|
|
|
|
|
|||
Current assets:
|
|
|
|
|
|||
Cash and cash equivalents
|
$
|
23,559
|
|
|
$
|
44,848
|
|
Short-term investments
|
212,093
|
|
|
104,410
|
|
||
Prepaid expenses and other current assets
|
19,945
|
|
|
2,529
|
|
||
Total current assets
|
255,597
|
|
|
151,787
|
|
||
Property and equipment, net
|
16,151
|
|
|
7,241
|
|
||
Long-term investments
|
22,199
|
|
|
108,116
|
|
||
Other non-current assets
|
2,713
|
|
|
4,168
|
|
||
Total assets
|
$
|
296,660
|
|
|
$
|
271,312
|
|
Liabilities, convertible preferred stock, contingently redeemable common stock and stockholders’ equity (deficit):
|
|
|
|
|
|||
Current liabilities:
|
|
|
|
|
|||
Accounts payable
|
$
|
2,849
|
|
|
$
|
3,511
|
|
Accrued expenses
|
8,454
|
|
|
5,855
|
|
||
Deferred rent and lease incentive, current
|
61
|
|
|
720
|
|
||
Deferred revenue, current—related party
|
51,142
|
|
|
80,544
|
|
||
Other current liabilities
|
45
|
|
|
43
|
|
||
Total current liabilities
|
62,551
|
|
|
90,673
|
|
||
Deferred rent and lease incentive, net of current portion
|
1,955
|
|
|
1,452
|
|
||
Deferred revenue, net of current portion—related party
|
65,018
|
|
|
107,260
|
|
||
Other non-current liabilities
|
27
|
|
|
56
|
|
||
Total liabilities
|
129,551
|
|
|
199,441
|
|
||
Commitments and contingencies (Note 15)
|
|
|
|
|
|
||
Convertible preferred stock (Series A), $0.001 par value: No shares and 47,000 shares authorized, issued and outstanding at December 31, 2017 and 2016, respectively
|
—
|
|
|
47,112
|
|
||
Convertible preferred stock (Series B), $0.001 par value: No shares and 24,779 shares authorized, issued and outstanding at December 31, 2017 and 2016, respectively
|
—
|
|
|
55,849
|
|
||
Convertible preferred stock (Series B-1), $0.001 par value: No shares and 10,448 shares authorized, issued and outstanding at December 31, 2017 and 2016, respectively
|
—
|
|
|
36,077
|
|
||
Contingently redeemable common stock
|
—
|
|
|
1,921
|
|
||
Stockholders’ equity (deficit):
|
|
|
|
|
|||
Preferred stock, $0.001 par value: 5,000 shares and no shares authorized at December 31, 2017 and 2016, respectively; no shares issued or outstanding at December 31, 2017 or 2016
|
—
|
|
|
—
|
|
||
Common stock, $0.001 par value: 160,000 shares and 29,810 shares authorized at December 31, 2017 and 2016, respectively; 32,265 and 2,518 shares issued at December 31, 2017 and 2016, respectively; 32,249 and 2,424 shares outstanding at December 31, 2017 and 2016, respectively
|
32
|
|
|
2
|
|
||
Additional paid-in capital
|
257,101
|
|
|
4,515
|
|
||
Accumulated other comprehensive loss
|
(409
|
)
|
|
(433
|
)
|
||
Accumulated deficit
|
(89,615
|
)
|
|
(73,172
|
)
|
||
Total stockholders’ equity (deficit)
|
167,109
|
|
|
(69,088
|
)
|
||
Total liabilities, convertible preferred stock, contingently redeemable common stock and stockholders’ equity (deficit)
|
$
|
296,660
|
|
|
$
|
271,312
|
|
|
Year Ended December 31,
|
||||||||||
|
2017
|
|
2016
|
|
2015
|
||||||
Revenue:
|
|
|
|
|
|
||||||
Collaboration revenue—related party
|
$
|
71,644
|
|
|
$
|
37,197
|
|
|
$
|
—
|
|
Operating expenses:
|
|
|
|
|
|
|
|
||||
Research and development
|
67,798
|
|
|
34,904
|
|
|
22,130
|
|
|||
General and administrative
|
23,061
|
|
|
16,759
|
|
|
8,266
|
|
|||
Total operating expenses
|
90,859
|
|
|
51,663
|
|
|
30,396
|
|
|||
Operating loss
|
(19,215
|
)
|
|
(14,466
|
)
|
|
(30,396
|
)
|
|||
Other income, net:
|
|
|
|
|
|
||||||
Other income, net
|
2,808
|
|
|
763
|
|
|
5
|
|
|||
Other financing income, net
|
—
|
|
|
—
|
|
|
1,859
|
|
|||
Total other income, net
|
2,808
|
|
|
763
|
|
|
1,864
|
|
|||
Loss before provision for income taxes
|
(16,407
|
)
|
|
(13,703
|
)
|
|
(28,532
|
)
|
|||
Provision for income taxes
|
36
|
|
|
—
|
|
|
—
|
|
|||
Net loss
|
$
|
(16,443
|
)
|
|
$
|
(13,703
|
)
|
|
$
|
(28,532
|
)
|
|
|
|
|
|
|
||||||
Reconciliation of net loss to net loss attributable to common stockholders:
|
|
|
|
|
|
||||||
Net loss
|
$
|
(16,443
|
)
|
|
$
|
(13,703
|
)
|
|
$
|
(28,532
|
)
|
Accretion of convertible preferred stock to redemption value
|
—
|
|
|
—
|
|
|
(1,011
|
)
|
|||
Loss on extinguishment of convertible preferred stock
|
—
|
|
|
—
|
|
|
(2,079
|
)
|
|||
Accrued dividends on Series A convertible preferred stock
|
(268
|
)
|
|
(3,760
|
)
|
|
(2,716
|
)
|
|||
Accrued dividends on Series B convertible preferred stock
|
(318
|
)
|
|
(4,460
|
)
|
|
(3,165
|
)
|
|||
Accrued dividends on Series B-1 convertible preferred stock
|
(208
|
)
|
|
(1,215
|
)
|
|
—
|
|
|||
Net loss attributable to common stockholders
|
$
|
(17,237
|
)
|
|
$
|
(23,138
|
)
|
|
$
|
(37,503
|
)
|
Net loss per share attributable to common stockholders, basic and diluted
|
$
|
(0.57
|
)
|
|
$
|
(11.00
|
)
|
|
$
|
(23.13
|
)
|
Weighted-average common shares outstanding, basic and diluted
|
30,055
|
|
|
2,103
|
|
|
1,621
|
|
|
Year Ended December 31,
|
||||||||||
|
2017
|
|
2016
|
|
2015
|
||||||
Net loss
|
$
|
(16,443
|
)
|
|
$
|
(13,703
|
)
|
|
$
|
(28,532
|
)
|
Other comprehensive income (loss):
|
|
|
|
|
|
||||||
Unrealized gain (loss) on available-for-sale securities
|
24
|
|
|
(433
|
)
|
|
—
|
|
|||
Comprehensive loss
|
$
|
(16,419
|
)
|
|
$
|
(14,136
|
)
|
|
$
|
(28,532
|
)
|
|
Series A Convertible
Preferred Stock
|
|
Series B Convertible
Preferred Stock
|
|
Series B-1 Convertible
Preferred Stock
|
|
Contingently Redeemable Common Stock
|
|
|
Common Stock
|
|
Additional Paid-In Capital
|
|
Accumulated Other Comprehensive Loss
|
|
Accumulated Deficit
|
|
Total Stockholders’
(Deficit) Equity
|
||||||||||||||||||||||||||||||
|
Shares
|
|
Amount
|
|
Shares
|
|
Amount
|
|
Shares
|
|
Amount
|
|
Amount
|
|
|
Shares
|
|
Amount
|
|
|||||||||||||||||||||||||||||
Balance at December 31, 2014
|
32,000
|
|
|
$
|
27,313
|
|
|
—
|
|
|
$
|
—
|
|
|
—
|
|
|
$
|
—
|
|
|
$
|
152
|
|
|
|
1,414
|
|
|
$
|
2
|
|
|
$
|
3
|
|
|
$
|
—
|
|
|
$
|
(28,005
|
)
|
|
$
|
(28,000
|
)
|
Issuances of Series A convertible preferred stock, net of issuance costs of $16
|
15,000
|
|
|
14,984
|
|
|
—
|
|
|
—
|
|
|
—
|
|
|
—
|
|
|
—
|
|
|
|
—
|
|
|
—
|
|
|
—
|
|
|
—
|
|
|
—
|
|
|
—
|
|
|||||||||
Reclassification of tranche rights upon issuance of preferred stock
|
—
|
|
|
1,725
|
|
|
—
|
|
|
—
|
|
|
—
|
|
|
—
|
|
|
—
|
|
|
|
—
|
|
|
—
|
|
|
—
|
|
|
—
|
|
|
—
|
|
|
—
|
|
|||||||||
Issuance of Series B convertible preferred stock, net of issuance costs of $151
|
—
|
|
|
—
|
|
|
24,779
|
|
|
55,849
|
|
|
—
|
|
|
—
|
|
|
—
|
|
|
|
—
|
|
|
—
|
|
|
—
|
|
|
—
|
|
|
—
|
|
|
—
|
|
|||||||||
Exercise of common stock options
|
—
|
|
|
—
|
|
|
—
|
|
|
—
|
|
|
—
|
|
|
—
|
|
|
—
|
|
|
|
6
|
|
|
—
|
|
|
3
|
|
|
—
|
|
|
—
|
|
|
3
|
|
|||||||||
Vesting of restricted common stock
|
—
|
|
|
—
|
|
|
—
|
|
|
—
|
|
|
—
|
|
|
—
|
|
|
—
|
|
|
|
413
|
|
|
—
|
|
|
10
|
|
|
—
|
|
|
—
|
|
|
10
|
|
|||||||||
Stock-based compensation expense
|
—
|
|
|
—
|
|
|
—
|
|
|
—
|
|
|
—
|
|
|
—
|
|
|
503
|
|
|
|
—
|
|
|
—
|
|
|
849
|
|
|
—
|
|
|
—
|
|
|
849
|
|
|||||||||
Accretion of preferred stock to redemption value
|
—
|
|
|
1,011
|
|
|
—
|
|
|
—
|
|
|
—
|
|
|
—
|
|
|
—
|
|
|
|
—
|
|
|
—
|
|
|
(158
|
)
|
|
—
|
|
|
(853
|
)
|
|
(1,011
|
)
|
|||||||||
Extinguishment of Series A convertible preferred stock
|
—
|
|
|
2,079
|
|
|
—
|
|
|
—
|
|
|
—
|
|
|
—
|
|
|
—
|
|
|
|
—
|
|
|
—
|
|
|
—
|
|
|
—
|
|
|
(2,079
|
)
|
|
(2,079
|
)
|
|||||||||
Net loss
|
—
|
|
|
—
|
|
|
—
|
|
|
—
|
|
|
—
|
|
|
—
|
|
|
—
|
|
|
|
—
|
|
|
—
|
|
|
—
|
|
|
—
|
|
|
(28,532
|
)
|
|
(28,532
|
)
|
|||||||||
Balance at December 31, 2015
|
47,000
|
|
|
47,112
|
|
|
24,779
|
|
|
55,849
|
|
|
—
|
|
|
—
|
|
|
655
|
|
|
|
1,833
|
|
|
2
|
|
|
707
|
|
|
—
|
|
|
(59,469
|
)
|
|
(58,760
|
)
|
|||||||||
Issuance of Series B-1 convertible preferred stock, net of issuance costs of $74
|
—
|
|
|
—
|
|
|
—
|
|
|
—
|
|
|
10,448
|
|
|
36,077
|
|
|
—
|
|
|
|
—
|
|
|
—
|
|
|
—
|
|
|
—
|
|
|
—
|
|
|
—
|
|
|||||||||
Exercise of common stock options
|
—
|
|
|
—
|
|
|
—
|
|
|
—
|
|
|
—
|
|
|
—
|
|
|
—
|
|
|
|
53
|
|
|
—
|
|
|
50
|
|
|
—
|
|
|
—
|
|
|
50
|
|
|||||||||
Vesting of restricted common stock
|
—
|
|
|
—
|
|
|
—
|
|
|
—
|
|
|
—
|
|
|
—
|
|
|
—
|
|
|
|
538
|
|
|
—
|
|
|
35
|
|
|
—
|
|
|
—
|
|
|
35
|
|
|||||||||
Stock-based compensation expense
|
—
|
|
|
—
|
|
|
—
|
|
|
—
|
|
|
—
|
|
|
—
|
|
|
1,266
|
|
|
|
—
|
|
|
—
|
|
|
3,723
|
|
|
—
|
|
|
—
|
|
|
3,723
|
|
|||||||||
Other comprehensive loss
|
—
|
|
|
—
|
|
|
—
|
|
|
—
|
|
|
—
|
|
|
—
|
|
|
—
|
|
|
|
—
|
|
|
—
|
|
|
—
|
|
|
(433
|
)
|
|
—
|
|
|
(433
|
)
|
|||||||||
Net loss
|
—
|
|
|
—
|
|
|
—
|
|
|
—
|
|
|
—
|
|
|
—
|
|
|
—
|
|
|
|
—
|
|
|
—
|
|
|
—
|
|
|
—
|
|
|
(13,703
|
)
|
|
(13,703
|
)
|
|||||||||
Balance at December 31, 2016
|
47,000
|
|
|
47,112
|
|
|
24,779
|
|
|
55,849
|
|
|
10,448
|
|
|
36,077
|
|
|
1,921
|
|
|
|
2,424
|
|
|
2
|
|
|
4,515
|
|
|
(433
|
)
|
|
(73,172
|
)
|
|
(69,088
|
)
|
|||||||||
Issuance of common stock from initial public offering, net of issuance costs of $2,529
|
—
|
|
|
—
|
|
|
—
|
|
|
—
|
|
|
—
|
|
|
—
|
|
|
—
|
|
|
|
7,320
|
|
|
7
|
|
|
106,381
|
|
|
—
|
|
|
—
|
|
|
106,388
|
|
|||||||||
Conversion of convertible preferred stock into common stock upon closing of initial public offering
|
(47,000
|
)
|
|
(47,112
|
)
|
|
(24,779
|
)
|
|
(55,849
|
)
|
|
(10,448
|
)
|
|
(36,077
|
)
|
|
—
|
|
|
|
22,284
|
|
|
23
|
|
|
139,015
|
|
|
—
|
|
|
—
|
|
|
139,038
|
|
|||||||||
Reclassification of restricted stock awards upon termination of put option
|
—
|
|
|
—
|
|
|
—
|
|
|
—
|
|
|
—
|
|
|
—
|
|
|
(2,191
|
)
|
|
|
—
|
|
|
—
|
|
|
2,191
|
|
|
—
|
|
|
—
|
|
|
2,191
|
|
|||||||||
Exercise of common stock options
|
—
|
|
|
—
|
|
|
—
|
|
|
—
|
|
|
—
|
|
|
—
|
|
|
—
|
|
|
|
144
|
|
|
—
|
|
|
462
|
|
|
—
|
|
|
—
|
|
|
462
|
|
|||||||||
Vesting of restricted common stock
|
—
|
|
|
—
|
|
|
—
|
|
|
—
|
|
|
—
|
|
|
—
|
|
|
—
|
|
|
|
77
|
|
|
—
|
|
|
32
|
|
|
—
|
|
|
—
|
|
|
32
|
|
|||||||||
Stock-based compensation expense
|
—
|
|
|
—
|
|
|
—
|
|
|
—
|
|
|
—
|
|
|
—
|
|
|
270
|
|
|
|
—
|
|
|
—
|
|
|
4,505
|
|
|
—
|
|
|
—
|
|
|
4,505
|
|
|||||||||
Other comprehensive loss
|
—
|
|
|
—
|
|
|
—
|
|
|
—
|
|
|
—
|
|
|
—
|
|
|
—
|
|
|
|
—
|
|
|
—
|
|
|
—
|
|
|
24
|
|
|
—
|
|
|
24
|
|
|||||||||
Net loss
|
—
|
|
|
—
|
|
|
—
|
|
|
—
|
|
|
—
|
|
|
—
|
|
|
—
|
|
|
|
—
|
|
|
—
|
|
|
—
|
|
|
—
|
|
|
(16,443
|
)
|
|
(16,443
|
)
|
|||||||||
Balance at December 31, 2017
|
—
|
|
|
$
|
—
|
|
|
—
|
|
|
$
|
—
|
|
|
—
|
|
|
$
|
—
|
|
|
$
|
—
|
|
|
|
32,249
|
|
|
$
|
32
|
|
|
$
|
257,101
|
|
|
$
|
(409
|
)
|
|
$
|
(89,615
|
)
|
|
$
|
167,109
|
|
|
Year Ended December 31,
|
||||||||||
|
2017
|
|
2016
|
|
2015
|
||||||
Operating activities:
|
|
|
|
|
|
|
|||||
Net loss
|
$
|
(16,443
|
)
|
|
$
|
(13,703
|
)
|
|
$
|
(28,532
|
)
|
Adjustments to reconcile net loss to net cash (used in) provided by operating activities:
|
|
|
|
|
|
|
|||||
Stock-based compensation expense
|
4,775
|
|
|
4,989
|
|
|
1,352
|
|
|||
Depreciation expense
|
4,422
|
|
|
1,944
|
|
|
1,470
|
|
|||
Change in other financing income, net
|
—
|
|
|
—
|
|
|
(1,859
|
)
|
|||
Net amortization of premiums and discounts on investments
|
1,172
|
|
|
327
|
|
|
—
|
|
|||
Loss on disposal of property and equipment
|
75
|
|
|
—
|
|
|
—
|
|
|||
Changes in operating assets and liabilities:
|
|
|
|
|
|
|
|||||
Prepaid expenses and other current assets
|
(17,416
|
)
|
|
(1,979
|
)
|
|
(23
|
)
|
|||
Other non-current assets
|
(16
|
)
|
|
(527
|
)
|
|
(99
|
)
|
|||
Accounts payable
|
373
|
|
|
(312
|
)
|
|
673
|
|
|||
Accrued expenses and other current liabilities
|
4,120
|
|
|
953
|
|
|
1,929
|
|
|||
Deferred revenue—related party
|
(71,644
|
)
|
|
187,804
|
|
|
—
|
|
|||
Other non-current liabilities
|
—
|
|
|
—
|
|
|
(28
|
)
|
|||
Deferred rent
|
(156
|
)
|
|
192
|
|
|
(622
|
)
|
|||
Net cash (used in) provided by operating activities
|
(90,738
|
)
|
|
179,688
|
|
|
(25,739
|
)
|
|||
Investing activities:
|
|
|
|
|
|
|
|
||||
Purchases of investments
|
(179,874
|
)
|
|
(213,286
|
)
|
|
—
|
|
|||
Proceeds from maturities of investments
|
141,322
|
|
|
—
|
|
|
—
|
|
|||
Proceeds from sales of investments
|
15,638
|
|
|
—
|
|
|
—
|
|
|||
Purchases of property and equipment
|
(15,107
|
)
|
|
(2,222
|
)
|
|
(2,202
|
)
|
|||
Change in restricted cash
|
—
|
|
|
—
|
|
|
60
|
|
|||
Net cash used in investing activities
|
(38,021
|
)
|
|
(215,508
|
)
|
|
(2,142
|
)
|
|||
Financing activities:
|
|
|
|
|
|
|
|
||||
Proceeds from the issuance of Series A convertible preferred stock and Tranche Rights, net of issuance costs
|
—
|
|
|
—
|
|
|
14,984
|
|
|||
Proceeds from the issuance of Series B convertible preferred stock, net of issuance costs
|
—
|
|
|
—
|
|
|
55,849
|
|
|||
Proceeds from the issuance of Series B-1 convertible preferred stock, net of issuance costs
|
—
|
|
|
36,077
|
|
|
—
|
|
|||
Proceeds from initial public offering of common stock, net of issuance costs
|
107,008
|
|
|
—
|
|
|
—
|
|
|||
Proceeds from exercise of stock options and purchases of restricted stock
|
462
|
|
|
50
|
|
|
112
|
|
|||
Cash paid for issuance costs
|
—
|
|
|
(620
|
)
|
|
(241
|
)
|
|||
Net cash provided by financing activities
|
107,470
|
|
|
35,507
|
|
|
70,704
|
|
|||
Net (decrease) increase in cash and cash equivalents
|
(21,289
|
)
|
|
(313
|
)
|
|
42,823
|
|
|||
Cash and cash equivalents, beginning of period
|
44,848
|
|
|
45,161
|
|
|
2,338
|
|
|||
Cash and cash equivalents, end of period
|
$
|
23,559
|
|
|
$
|
44,848
|
|
|
$
|
45,161
|
|
Non-cash investing and financing activities:
|
|
|
|
|
|
|
|
||||
Accretion of convertible preferred stock to redemption value
|
$
|
—
|
|
|
$
|
—
|
|
|
$
|
1,011
|
|
Reclassification of preferred stock tranche liability upon settlement
|
$
|
—
|
|
|
$
|
—
|
|
|
$
|
1,725
|
|
Purchases of property and equipment in accounts payable and accrued expenses
|
$
|
170
|
|
|
$
|
1,870
|
|
|
$
|
22
|
|
Issuance costs in accounts payable and accrued expenses
|
$
|
—
|
|
|
$
|
850
|
|
|
$
|
1,580
|
|
Supplemental cash flow information:
|
|
|
|
|
|
||||||
Cash paid for income taxes
|
$
|
16,750
|
|
|
$
|
—
|
|
|
$
|
—
|
|
•
|
Level 1 inputs are quoted prices (unadjusted) in active markets for identical assets or liabilities.
|
•
|
Level 2 inputs are inputs other than quoted prices included within Level 1 that are observable for the asset or liability, either directly or indirectly.
|
•
|
Level 3 inputs are unobservable inputs that reflect the Company’s own assumptions about the assumptions market participants would use in pricing the asset or liability. Financial assets and liabilities are classified in their entirety based on the lowest level of input that is significant to the fair value measurement.
|
•
|
persuasive evidence of an arrangement exists;
|
•
|
delivery has occurred or services have been rendered;
|
•
|
the seller’s price to the buyer is fixed or determinable; and
|
•
|
collectability is reasonably assured.
|
•
|
In August 2015, the FASB issued ASU 2015-14, Revenue from Contracts with Customers (Topic 606): Deferral of the Effective Date, whereby the effective date for the new revenue standard was deferred by one year. As a result of ASU 2015-14, the new revenue standard is now effective for annual periods, and interim periods within those annual periods, beginning after December 15, 2017, and early adoption is now permitted for annual periods beginning after December 15, 2016, including interim periods within that annual period.
|
•
|
In March 2016, the FASB issued ASU 2016-08, Revenue from Contracts with Customers (Topic 606): Principal versus Agent Considerations (Reporting Revenue Gross versus Net), to clarify the implementation guidance on principal versus agent considerations.
|
•
|
In April 2016, the FASB issued ASU 2016-10, Revenue from Contracts with Customers (Topic 606): Identifying Performance Obligations and Licensing, to clarify the principle for determining whether a good or service is “separately identifiable” from other promises in the contract and to clarify the categorization of licenses of intellectual property.
|
•
|
In May 2016, the FASB issued ASU 2016-12, Revenue from Contracts with Customers (Topic 606): Narrow-Scope Improvements and Technical Expedients, to clarify guidance on transition, determining collectability, non-cash consideration and the presentation of sales and other similar taxes.
|
•
|
In December 2016, the FASB issued ASU 2016-20, Technical Corrections and Improvements to Topic 606, Revenue from Contracts with Customers, that allows entities not to make qualitative disclosures about remaining performance obligations in certain cases, adds disclosure requirements for entities that elect certain optional exemptions and adds twelve additional technical corrections and improvements to the new revenue standard.
|
•
|
The Company will retain
60
percent of the U.S. operating profits or losses arising from commercialization of JTX-2011, with
40
percent allocated to Celgene.
|
•
|
The Company will retain
25
percent of the U.S. operating profits or losses arising from commercialization of the first program (the “Lead Program”), other than JTX-2011 or JTX-4014, for which an IND application is filed under the collaboration, with
75
percent allocated to Celgene. Celgene has a one-time right to substitute and swap the economics and governance of this program with that of another program for which it exercises an option (other than JTX-2011 and JTX-4014).
|
•
|
The Company and Celgene will equally share U.S. operating profits or losses arising from commercialization of up to three additional programs (other than JTX-2011, JTX-4014 or the Lead Program) (the “Other Programs”).
|
•
|
The Company and Celgene will share all development costs, other than for JTX-4014, in accordance with the applicable Co-Co Agreements, of which Celgene’s portion of the costs range from
67
percent to
85
percent.
|
|
Total
|
|
Quoted Prices in Active Markets for Identical Assets (Level 1)
|
|
Significant Other Observable Inputs (Level 2)
|
|
Significant Unobservable Inputs
(Level 3)
|
||||||||
Money market funds, included in cash equivalents
|
$
|
21,059
|
|
|
$
|
21,059
|
|
|
$
|
—
|
|
|
$
|
—
|
|
Investments:
|
|
|
|
|
|
|
|
||||||||
Corporate debt securities
|
65,173
|
|
|
—
|
|
|
65,173
|
|
|
—
|
|
||||
U.S. Treasuries
|
110,948
|
|
|
110,948
|
|
|
—
|
|
|
—
|
|
||||
Government agency securities
|
58,171
|
|
|
58,171
|
|
|
—
|
|
|
—
|
|
||||
Totals
|
$
|
255,351
|
|
|
$
|
190,178
|
|
|
$
|
65,173
|
|
|
$
|
—
|
|
|
December 31, 2016
|
|
Quoted Prices in Active Markets for Identical Assets (Level 1)
|
|
Significant Other Observable Inputs (Level 2)
|
|
Significant Unobservable Inputs
(Level 3) |
||||||||
Money market funds, included in cash equivalents
|
$
|
44,848
|
|
|
$
|
44,848
|
|
|
$
|
—
|
|
|
$
|
—
|
|
Investments:
|
|
|
|
|
|
|
|
|
|
|
|||||
Corporate debt securities
|
92,408
|
|
|
—
|
|
|
92,408
|
|
|
—
|
|
||||
U.S. Treasuries
|
120,118
|
|
|
120,118
|
|
|
—
|
|
|
—
|
|
||||
Totals
|
$
|
257,374
|
|
|
$
|
164,966
|
|
|
$
|
92,408
|
|
|
$
|
—
|
|
|
December 31, 2017
|
||||||||||||||
|
Amortized Cost
|
|
Unrealized Gains
|
|
Unrealized Losses
|
|
Fair Value
|
||||||||
Cash equivalents and short-term investments:
|
|
|
|
|
|
|
|
|
|
|
|||||
Money market funds, included in cash equivalents
|
$
|
21,059
|
|
|
$
|
—
|
|
|
$
|
—
|
|
|
$
|
21,059
|
|
Corporate debt securities
|
58,136
|
|
|
—
|
|
|
(64
|
)
|
|
58,072
|
|
||||
U.S. Treasuries
|
111,049
|
|
|
—
|
|
|
(101
|
)
|
|
110,948
|
|
||||
Government agency securities
|
43,204
|
|
|
—
|
|
|
(131
|
)
|
|
43,073
|
|
||||
Total cash equivalents and short-term investments
|
233,448
|
|
|
—
|
|
|
(296
|
)
|
|
233,152
|
|
||||
Long-term investments:
|
|
|
|
|
|
|
|
|
|
|
|||||
Corporate debt securities
|
7,117
|
|
|
—
|
|
|
(16
|
)
|
|
7,101
|
|
||||
Government agency securities
|
15,195
|
|
|
—
|
|
|
(97
|
)
|
|
15,098
|
|
||||
Total long-term investments
|
22,312
|
|
|
—
|
|
|
(113
|
)
|
|
22,199
|
|
||||
Total cash equivalents and investments
|
$
|
255,760
|
|
|
$
|
—
|
|
|
$
|
(409
|
)
|
|
$
|
255,351
|
|
|
December 31, 2016
|
||||||||||||||
|
Amortized Cost
|
|
Unrealized Gains
|
|
Unrealized Losses
|
|
Fair Value
|
||||||||
Cash equivalents and short-term investments:
|
|
|
|
|
|
|
|
|
|
|
|||||
Money market funds, included in cash equivalents
|
$
|
44,848
|
|
|
$
|
—
|
|
|
$
|
—
|
|
|
$
|
44,848
|
|
Corporate debt securities
|
92,549
|
|
|
—
|
|
|
(141
|
)
|
|
92,408
|
|
||||
U.S. Treasuries
|
12,020
|
|
|
—
|
|
|
(18
|
)
|
|
12,002
|
|
||||
Total cash equivalents and short-term investments
|
149,417
|
|
|
—
|
|
|
(159
|
)
|
|
149,258
|
|
||||
Long-term investments:
|
|
|
|
|
|
|
|
|
|
|
|||||
U.S. Treasuries
|
108,390
|
|
|
—
|
|
|
(274
|
)
|
|
108,116
|
|
||||
Total long-term investments
|
108,390
|
|
|
—
|
|
|
(274
|
)
|
|
108,116
|
|
||||
Total cash equivalents and investments
|
$
|
257,807
|
|
|
$
|
—
|
|
|
$
|
(433
|
)
|
|
$
|
257,374
|
|
|
December 31,
|
||||||
|
2017
|
|
2016
|
||||
Prepaid expenses
|
$
|
2,196
|
|
|
$
|
1,310
|
|
Taxes receivable
|
16,737
|
|
|
—
|
|
||
Interest receivable on investments
|
969
|
|
|
709
|
|
||
Other current assets
|
43
|
|
|
510
|
|
||
Total prepaid expenses and other current assets
|
$
|
19,945
|
|
|
$
|
2,529
|
|
|
Estimated Useful Life (in Years)
|
|
December 31,
|
||||||
|
|
2017
|
|
2016
|
|||||
Laboratory equipment
|
5
|
|
$
|
9,409
|
|
|
$
|
6,275
|
|
Furniture and office equipment
|
4
|
|
1,038
|
|
|
226
|
|
||
Computer equipment
|
3
|
|
1,380
|
|
|
492
|
|
||
Leasehold improvements
|
Shorter of useful life or remaining lease term
|
|
8,498
|
|
|
3,997
|
|
||
Construction in progress
|
|
|
—
|
|
|
1,048
|
|
||
Total property and equipment, gross
|
|
|
20,325
|
|
|
12,038
|
|
||
Less: accumulated depreciation
|
|
|
(4,174
|
)
|
|
(4,797
|
)
|
||
Total property and equipment, net
|
|
|
$
|
16,151
|
|
|
$
|
7,241
|
|
|
December 31,
|
||||||
|
2017
|
|
2016
|
||||
Employee compensation and benefits
|
$
|
3,683
|
|
|
$
|
2,651
|
|
External research and professional services
|
4,647
|
|
|
1,923
|
|
||
Lab consumables and other
|
124
|
|
|
1,281
|
|
||
Total accrued expenses
|
$
|
8,454
|
|
|
$
|
5,855
|
|
|
December 31,
|
||||
|
2017
|
|
2016
|
||
Shares reserved for Series A convertible preferred stock outstanding
|
—
|
|
|
12,737
|
|
Shares reserved for Series B convertible preferred stock outstanding
|
—
|
|
|
6,715
|
|
Shares reserved for Series B-1 convertible preferred stock outstanding
|
—
|
|
|
2,831
|
|
Shares reserved for vesting of restricted stock awards
|
16
|
|
|
94
|
|
Shares reserved for exercises of outstanding stock options
|
4,868
|
|
|
4,290
|
|
Shares reserved for future issuances under the 2017 Stock Incentive Plan
|
1,032
|
|
|
244
|
|
Total shares reserved for future issuance
|
5,916
|
|
|
26,911
|
|
|
Year Ended December 31,
|
||||||||||
|
2017
|
|
2016
|
|
2015
|
||||||
Research and development
|
$
|
2,840
|
|
|
$
|
4,161
|
|
|
$
|
269
|
|
General and administrative
|
1,935
|
|
|
828
|
|
|
1,083
|
|
|||
Total stock-based compensation expense
|
$
|
4,775
|
|
|
$
|
4,989
|
|
|
$
|
1,352
|
|
|
Shares
|
|
Weighted-Average Grant Date Fair Value per Share
|
|||
Unvested restricted stock as of December 31, 2016
|
94
|
|
|
$
|
0.07
|
|
Issued
|
—
|
|
|
$
|
—
|
|
Vested
|
(77
|
)
|
|
$
|
0.08
|
|
Repurchased
|
(1
|
)
|
|
$
|
0.37
|
|
Unvested restricted stock as of December 31, 2017
|
16
|
|
|
$
|
—
|
|
|
Year Ended December 31,
|
|||||||
|
2017
|
|
2016
|
|
2015
|
|||
Risk-free interest rate
|
2.1
|
%
|
|
1.4
|
%
|
|
1.8
|
%
|
Expected dividend yield
|
—
|
%
|
|
—
|
%
|
|
—
|
%
|
Expected term (in years)
|
6.1
|
|
|
6.1
|
|
|
6.1
|
|
Expected volatility
|
70.1
|
%
|
|
71.9
|
%
|
|
67.0
|
%
|
|
Options
|
|
Weighted-Average Exercise Price
|
|
Weighted-Average Remaining Contractual Term (in years)
|
|
Aggregate Intrinsic Value
|
|||||
Outstanding at December 31, 2016
|
4,290
|
|
|
$
|
3.95
|
|
|
8.7
|
|
$
|
29,269
|
|
Granted
|
983
|
|
|
$
|
17.19
|
|
|
|
|
|
|
|
Exercised
|
(144
|
)
|
|
$
|
3.20
|
|
|
|
|
|
|
|
Cancelled or forfeited
|
(261
|
)
|
|
$
|
10.71
|
|
|
|
|
|
|
|
Outstanding at December 31, 2017
|
4,868
|
|
|
$
|
6.28
|
|
|
7.9
|
|
$
|
35,178
|
|
Exercisable at December 31, 2017
|
2,217
|
|
|
$
|
2.79
|
|
|
7.2
|
|
$
|
22,170
|
|
|
Year Ended December 31,
|
||||||||||
|
2017
|
|
2016
|
|
2015
|
||||||
Current taxes:
|
|
|
|
|
|
||||||
Federal
|
$
|
—
|
|
|
$
|
—
|
|
|
$
|
—
|
|
State
|
36
|
|
|
—
|
|
|
—
|
|
|||
Total current taxes
|
36
|
|
|
—
|
|
|
—
|
|
|||
Deferred taxes:
|
|
|
|
|
|
||||||
Federal
|
—
|
|
|
—
|
|
|
—
|
|
|||
State
|
—
|
|
|
—
|
|
|
—
|
|
|||
Total deferred taxes
|
—
|
|
|
—
|
|
|
—
|
|
|||
Total provision for income taxes
|
$
|
36
|
|
|
$
|
—
|
|
|
$
|
—
|
|
|
December 31,
|
||||||
|
2017
|
|
2016
|
||||
Deferred tax assets:
|
|
|
|
|
|||
Net operating loss carryforwards
|
$
|
26,926
|
|
|
$
|
24,435
|
|
Tax credit carryforwards
|
8,432
|
|
|
4,039
|
|
||
Deferred revenue
|
31,735
|
|
|
—
|
|
||
Deferred lease incentive
|
120
|
|
|
553
|
|
||
Deferred rent
|
431
|
|
|
426
|
|
||
Intangibles
|
237
|
|
|
187
|
|
||
Accrued expenses and other
|
995
|
|
|
1,018
|
|
||
Unrealized loss on available-for-sale securities
|
112
|
|
|
169
|
|
||
Stock-based compensation
|
713
|
|
|
293
|
|
||
Total deferred tax assets
|
69,701
|
|
|
31,120
|
|
||
Less: valuation allowance
|
(30,850
|
)
|
|
(30,548
|
)
|
||
Net deferred tax assets
|
38,851
|
|
|
572
|
|
||
Deferred tax liabilities:
|
|
|
|
||||
Section 481(a) method change
|
(38,481
|
)
|
|
—
|
|
||
Depreciation
|
(370
|
)
|
|
(572
|
)
|
||
Total deferred tax liabilities
|
(38,851
|
)
|
|
(572
|
)
|
||
Net deferred taxes
|
$
|
—
|
|
|
$
|
—
|
|
Years Ended December 31,
|
Minimum Lease Payments
|
||
2018
|
$
|
4,139
|
|
2019
|
4,263
|
|
|
2020
|
4,391
|
|
|
2021
|
4,523
|
|
|
2022
|
4,659
|
|
|
2023 and thereafter
|
10,996
|
|
|
Total future minimum lease payments
|
$
|
32,971
|
|
|
Year Ended December 31,
|
|||||||
|
2017
|
|
2016
|
|
2015
|
|||
Series A convertible preferred stock
|
—
|
|
|
12,737
|
|
|
12,737
|
|
Series B convertible preferred stock
|
—
|
|
|
6,715
|
|
|
6,715
|
|
Series B-1 convertible preferred stock
|
—
|
|
|
2,831
|
|
|
—
|
|
Outstanding stock options
|
4,868
|
|
|
4,290
|
|
|
2,960
|
|
Unvested restricted common stock
|
16
|
|
|
94
|
|
|
748
|
|
Total
|
4,884
|
|
|
26,667
|
|
|
23,160
|
|
|
2017
|
||||||||||||||
(in thousands, except per share data)
|
First Quarter
|
|
Second Quarter
|
|
Third Quarter
|
|
Fourth Quarter
|
||||||||
Collaboration revenue—related party
|
$
|
20,289
|
|
|
$
|
20,289
|
|
|
$
|
18,077
|
|
|
$
|
12,989
|
|
Total operating expenses
|
20,536
|
|
|
23,317
|
|
|
22,465
|
|
|
24,541
|
|
||||
Operating loss
|
(247
|
)
|
|
(3,028
|
)
|
|
(4,388
|
)
|
|
(11,552
|
)
|
||||
Total other income, net
|
632
|
|
|
752
|
|
|
721
|
|
|
703
|
|
||||
Provision for (benefit from) income taxes
|
—
|
|
|
1,104
|
|
|
417
|
|
|
(1,485
|
)
|
||||
Net income (loss)
|
$
|
385
|
|
|
$
|
(3,380
|
)
|
|
$
|
(4,084
|
)
|
|
$
|
(9,364
|
)
|
Net loss attributable to common stockholders
|
$
|
(409
|
)
|
|
$
|
(3,380
|
)
|
|
$
|
(4,084
|
)
|
|
$
|
(9,364
|
)
|
Net loss per share attributable to common stockholders, basic and diluted
|
$
|
(0.02
|
)
|
|
$
|
(0.11
|
)
|
|
$
|
(0.13
|
)
|
|
$
|
(0.29
|
)
|
|
2016
|
||||||||||||||
(in thousands, except per share data)
|
First Quarter
|
|
Second Quarter
|
|
Third Quarter
|
|
Fourth Quarter
|
||||||||
Collaboration revenue—related party
|
$
|
—
|
|
|
$
|
—
|
|
|
$
|
16,908
|
|
|
$
|
20,289
|
|
Total operating expenses
|
10,901
|
|
|
12,362
|
|
|
13,093
|
|
|
15,307
|
|
||||
Operating (loss) income
|
(10,901
|
)
|
|
(12,362
|
)
|
|
3,815
|
|
|
4,982
|
|
||||
Total other income, net
|
11
|
|
|
14
|
|
|
254
|
|
|
484
|
|
||||
Net (loss) income
|
$
|
(10,890
|
)
|
|
$
|
(12,348
|
)
|
|
$
|
4,069
|
|
|
$
|
5,466
|
|
Net (loss) income attributable to common stockholders
|
$
|
(12,934
|
)
|
|
$
|
(14,392
|
)
|
|
$
|
138
|
|
|
$
|
258
|
|
Net (loss) income per share attributable to common stockholders, basic
|
$
|
(6.81
|
)
|
|
$
|
(7.23
|
)
|
|
$
|
0.06
|
|
|
$
|
0.11
|
|
Net (loss) income per share attributable to common stockholders, diluted
|
$
|
(6.81
|
)
|
|
$
|
(7.23
|
)
|
|
$
|
0.03
|
|
|
$
|
0.05
|
|
Exhibit No.
|
|
Description of Exhibit
|
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
101*
|
|
The following materials from the Company’s Annual Report on Form 10-K for the year ended December 31, 2017, formatted in eXtensible Business Reporting Language (XBRL): (i) Consolidated Balance Sheets, (ii) Consolidated Statements of Operations, (iii) Consolidated Statements of Comprehensive Loss, (iv) Consolidated Statements of Convertible Preferred Stock, Contingently Redeemable Common Stock and Stockholders’ (Deficit) Equity, (v) Consolidated Statements of Cash Flows and (vi) Notes to Consolidated Financial Statements
|
|
|
|
*
|
|
Filed herewith
|
+
|
|
Furnished herewith
|
#
|
|
Indicates a management contract or any compensatory plan, contract or arrangement
|
†
|
|
Confidential treatment granted as to portions of the exhibit. Confidential materials omitted and filed separately with the Securities and Exchange Commission pursuant to Rule 406 of the Securities Act of 1933, as amended.
|
|
|
JOUNCE THERAPEUTICS, INC.
|
|
|
|
Date: March 8, 2018
|
By:
|
/s/ Richard Murray
|
|
|
Richard Murray, Ph.D.
|
|
|
President and Chief Executive Officer
|
Signature
|
|
Title
|
|
Date
|
/s/ Richard Murray
|
|
President, Chief Executive Officer and Director (Principal Executive Officer)
|
|
March 8, 2018
|
Richard Murray, Ph.D.
|
|
|
|
|
|
|
|
|
|
/s/ Kim C. Drapkin
|
|
Treasurer and Chief Financial Officer
(Principal Financial and Accounting Officer)
|
|
March 8, 2018
|
Kim C. Drapkin
|
|
|
|
|
|
|
|
|
|
/s/ Perry A. Karsen
|
|
Chairman of the Board of Directors
|
|
March 8, 2018
|
Perry A. Karsen
|
|
|
|
|
|
|
|
|
|
/s/ Barbara Duncan
|
|
Director
|
|
March 8, 2018
|
Barbara Duncan
|
|
|
|
|
|
|
|
|
|
/s/ Cary G. Pfeffer
|
|
Director
|
|
March 8, 2018
|
Cary G. Pfeffer, M.D.
|
|
|
|
|
|
|
|
|
|
/s/ J. Duncan Higgons
|
|
Director
|
|
March 8, 2018
|
J. Duncan Higgons
|
|
|
|
|
|
|
|
|
|
/s/ Robert Kamen
|
|
Director
|
|
March 8, 2018
|
Robert Kamen, Ph.D.
|
|
|
|
|
|
|
|
|
|
/s/ Robert Tepper
|
|
Director
|
|
March 8, 2018
|
Robert Tepper, M.D.
|
|
|
|
|
|
|
|
|
|
/s/ Luis A. Diaz, Jr.
|
|
Director
|
|
March 8, 2018
|
Luis A. Diaz, Jr., M.D.
|
|
|
|
|
|
|
|
Date: March 8, 2018
|
By:
|
/s/ Richard Murray
|
|
|
Richard Murray, Ph.D.
|
|
|
President and Chief Executive Officer
|
|
|
(Principal Executive Officer)
|
|
|
|
Date: March 8, 2018
|
By:
|
/s/ Kim C. Drapkin
|
|
|
Kim C. Drapkin
|
|
|
Treasurer and Chief Financial Officer
|
|
|
(Principal Financial and Accounting Officer)
|
|
|
|
Date: March 8, 2018
|
By:
|
/s/ Richard Murray
|
|
|
Richard Murray, Ph.D.
|
|
|
President and Chief Executive Officer
|
|
|
(Principal Executive Officer)
|
|
|
|
Date: March 8, 2018
|
By:
|
/s/ Kim C. Drapkin
|
|
|
Kim C. Drapkin
|
|
|
Treasurer and Chief Financial Officer
|
|
|
(Principal Financial and Accounting Officer)
|